Haoyu Tang

Works (6)

Updated: January 27th, 2026 10:13

2026 article

Correction to “Regio- and Stereoselective Halogenation by an Iron(II)- and 2-Oxoglutarate-Dependent Halogenase in the Biosynthesis of Halogenated Nucleosides”

Palacios, P. M., Li, X., Rifayee, S. B. J. S., Tang, H., Karabencheva-Christova, T., Christov, C., … Guo, Y. (2026, January 24). Correction to “Regio- and Stereoselective Halogenation by an Iron(II)- and 2-Oxoglutarate-Dependent Halogenase in the Biosynthesis of Halogenated Nucleosides.” Journal of the American Chemical Society, Vol. 1.

By: P. Palacios*, X. Li n, S. Rifayee *, H. Tang n, T. Karabencheva-Christova *, C. Christov *, W. Chang n , Y. Guo*

topics (OpenAlex): Vanadium and Halogenation Chemistry; Metal-Catalyzed Oxygenation Mechanisms; Metalloenzymes and iron-sulfur proteins
Sources: NC State University Libraries, NC State University Libraries
Added: January 26, 2026

2025 article

Regio- and Stereoselective Halogenation by an Iron(II)- and 2-Oxoglutarate-Dependent Halogenase in the Biosynthesis of Halogenated Nucleosides

Palacios, P. M., Li, X., Rifayee, S. B. J. S., Tang, H., Karabencheva-Christova, T., Christov, C., … Guo, Y. (2025, December 16). Journal of the American Chemical Society.

By: P. Palacios*, X. Li  n, S. Rifayee *, H. Tang n, T. Karabencheva-Christova *, C. Christov *, W. Chang n , Y. Guo *

MeSH headings : Halogenation; Ketoglutaric Acids / metabolism; Ketoglutaric Acids / chemistry; Stereoisomerism; Nucleosides / biosynthesis; Nucleosides / chemistry; Oxidoreductases / metabolism; Oxidoreductases / chemistry; Iron / metabolism; Iron / chemistry; Kinetics
topics (OpenAlex): Metal-Catalyzed Oxygenation Mechanisms; Metalloenzymes and iron-sulfur proteins; Cyclopropane Reaction Mechanisms
Sources: NC State University Libraries, NC State University Libraries
Added: December 18, 2025

2023 article

A Ferric-Superoxide Intermediate Initiates P450-Catalyzed Cyclic Dipeptide Dimerization

Gering, H. E., Li, X., Tang, H., Swartz, P. D., Chang, W.-C., & Makris, T. M. (2023, August 23). Journal of the American Chemical Society, Vol. 8.

By: H. Gering n, X. Li n, H. Tang n, P. Swartz n, W. Chang n  & T. Makris n 

MeSH headings : Superoxides; Dimerization; Iron; Cytochrome P-450 Enzyme System; Oxidants; Diketopiperazines; Dipeptides; Electrolytes; Catalysis
topics (OpenAlex): Alkaloids: synthesis and pharmacology; Pharmacogenetics and Drug Metabolism
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 11, 2023

2021 article

BesC Initiates C–C Cleavage through a Substrate-Triggered and Reactive Diferric-Peroxo Intermediate

Manley, O. M., Tang, H., Xue, S., Guo, Y., Chang, W.-chen, & Makris, T. M. (2021, December 13). Journal of the American Chemical Society, Vol. 12.

By: O. Manley  n, H. Tang n, S. Xue *, Y. Guo *, W. Chang n  & T. Makris n 

MeSH headings : Carbon / chemistry; Carbon / metabolism; Ferric Compounds / chemistry; Oxidoreductases / metabolism; Oxygen / chemistry; Spectroscopy, Mossbauer; Streptomyces / enzymology; Substrate Specificity
topics (OpenAlex): Metal-Catalyzed Oxygenation Mechanisms; Heme Oxygenase-1 and Carbon Monoxide; CO2 Reduction Techniques and Catalysts
TL;DR: The observed reactivity of BesC represents the first example of a dinuclear-iron enzyme that utilizes a diferric-peroxo intermediate to capably cleave a C-H bond as part of its native function, thus circumventing the formation of a high-valent intermediate more commonly associated with substrate monooxygenations. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 3, 2022

2021 article

Harnessing the Substrate Promiscuity of Dioxygenase AsqJ and Developing Efficient Chemoenzymatic Synthesis for Quinolones

Tang, H., Tang, Y., Kurnikov, I. V., Liao, H.-J., Chan, N.-L., Kurnikova, M. G., … Chang, W.-chen. (2021, June 6). ACS Catalysis, Vol. 6.

By: H. Tang n, Y. Tang *, I. Kurnikov *, H. Liao*, N. Chan *, M. Kurnikova *, Y. Guo *, W. Chang n 

author keywords: Fe/2OG enzyme; AsqJ; chemoenzymatic synthesis; rearrangement; quinolone
topics (OpenAlex): Alkaloids: synthesis and pharmacology; Chemical synthesis and alkaloids; Microbial Natural Products and Biosynthesis
TL;DR: By leveraging the power of chemo-enzymatic synthesis, a library of quinolone alkaloids is effectively prepared through chemoenzymatic cascades, and the robustness of this method in gram-scale reactions is evaluated. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: July 19, 2021

2021 article

Mechanistic analysis of carbon–carbon bond formation by deoxypodophyllotoxin synthase

Tang, H., Wu, M.-H., Lin, H.-Y., Han, M.-R., Tu, Y.-H., Yang, Z.-J., … Chang, W.-chen. (2021, December 28). Proceedings of the National Academy of Sciences, Vol. 1.

By: H. Tang n, M. Wu *, H. Lin *, M. Han*, Y. Tu*, Z. Yang *, T. Chien *, N. Chan *, W. Chang n 

author keywords: C-C coupling; cyclization; oxygenase; natural product; reaction mechanism
MeSH headings : Berberidaceae / enzymology; Drugs, Chinese Herbal / chemistry; Ligases / chemistry; Oxidation-Reduction; Plant Proteins / chemistry; Podophyllotoxin / analogs & derivatives; Podophyllotoxin / chemistry
topics (OpenAlex): Plant-derived Lignans Synthesis and Bioactivity; Metal-Catalyzed Oxygenation Mechanisms; Microbial Natural Products and Biosynthesis
TL;DR: This study reports two structures of DPS in complex with 2OG and (±)-yatein, in vitro analysis of enzymatic reactivity with substrate analogs, and model reactions addressing DPS’s catalytic mechanism, and suggests what types of substrate modification are likely tolerable in DPS-catalyzed production of deoxypodophyllotoxin analogs. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: February 21, 2022

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