Works (75)

Updated: September 1st, 2023 05:01

2023 journal article

Assembly path dependence of telomeric DNA compaction by TRF1, TIN2, and SA1

BIOPHYSICAL JOURNAL, 122(10), 1822–1832.

By: M. Liu n, H. Pan n, P. Kaur n, L. Wang n, M. Jin*, A. Detwiler*, P. Opresko*, Y. Tao*, H. Wang n, R. Riehn n

co-author countries: United States of America 🇺🇸
Sources: Web Of Science, ORCID
Added: April 21, 2023

2023 article

PARP1 associates with R-loops to promote their resolution and genome stability

Laspata, N., Kaur, P., Mersaoui, S. Y., Muoio, D., Liu, Z. S., Bannister, M. H., … Fouquerel, E. (2023, February 16). NUCLEIC ACIDS RESEARCH, Vol. 2.

By: N. Laspata*, P. Kaur*, S. Mersaoui*, D. Muoio*, Z. Liu*, M. Bannister*, H. Nguyen*, C. Curry* ...

co-author countries: Canada 🇨🇦 United States of America 🇺🇸
MeSH headings : Humans; DNA / chemistry; DNA Repair; Genomic Instability; Poly (ADP-Ribose) Polymerase-1 / genetics; Poly (ADP-Ribose) Polymerase-1 / metabolism; R-Loop Structures; RNA / chemistry
Sources: Web Of Science, ORCID
Added: March 20, 2023

2023 journal article

Single-molecule imaging of genome maintenance proteins encountering specific DNA sequences and structures

DNA REPAIR, 128.

By: E. Irvin n & H. Wang n

co-author countries: United States of America 🇺🇸
author keywords: Single-molecule imaging; High-speed AFM imaging; Mitochondrial DNA replication; Cohesin; Shelterin; Protein-DNA interactions
Sources: Web Of Science, ORCID
Added: August 7, 2023

2023 article

Structure-specific roles for PolG2-DNA complexes in maintenance and replication of mitochondrial DNA

Wojtaszek, J. L., Hoff, K. E., Longley, M. J., Kaur, P., Andres, S. N., Wang, H., … Copeland, W. C. (2023, August 18). NUCLEIC ACIDS RESEARCH, Vol. 8.

co-author countries: United States of America 🇺🇸
Sources: Web Of Science, ORCID
Added: August 28, 2023

2022 journal article

Densely methylated DNA traps Methyl-CpG-binding domain protein 2 but permits free diffusion by Methyl-CpG-binding domain protein 3

JOURNAL OF BIOLOGICAL CHEMISTRY, 298(10).

By: G. Leighton, E. Irvin*, P. Kaur*, M. Liu*, C. You, D. Bhattaram, J. Piehler, R. Riehn* ...

MeSH headings : CpG Islands; DNA Methylation; DNA-Binding Proteins / metabolism; Mi-2 Nucleosome Remodeling and Deacetylase Complex / genetics; Mi-2 Nucleosome Remodeling and Deacetylase Complex / metabolism; Nucleosomes; Protein Binding; Transcription Factors / metabolism; Humans; Single Molecule Imaging
Sources: Web Of Science, ORCID
Added: August 29, 2022

2022 article

Structural and dynamic basis of DNA capture and translocation by mitochondrial Twinkle helicase

Li, Z., Kaur, P., Lo, C.-Y., Chopra, N., Smith, J., Wang, H., & Gao, Y. (2022, November 18). NUCLEIC ACIDS RESEARCH, Vol. 11.

By: Z. Li*, P. Kaur n, C. Lo*, N. Chopra*, J. Smith*, H. Wang n, Y. Gao*

co-author countries: United States of America 🇺🇸
MeSH headings : Humans; Mitochondrial Proteins / metabolism; Cryoelectron Microscopy; DNA Helicases / metabolism; Mitochondria / genetics; Mitochondria / metabolism; DNA Replication; DNA, Mitochondrial / genetics
Sources: Web Of Science, ORCID
Added: December 5, 2022

2021 journal article

Structure, dynamics, and regulation of TRF1-TIN2-mediated trans- and cis-interactions on telomeric DNA

JOURNAL OF BIOLOGICAL CHEMISTRY, 297(3).

By: H. Pan n, P. Kaur n, R. Barnes*, A. Detwiler*, S. Sanford*, M. Liu n, P. Xu n, C. Mahn n ...

co-author countries: Germany 🇩🇪 United States of America 🇺🇸
MeSH headings : Cell Adhesion Molecules / metabolism; Cell Adhesion Molecules / physiology; DNA / metabolism; DNA-Binding Proteins / metabolism; Humans; Microscopy, Atomic Force / methods; Models, Molecular; Multiprotein Complexes / metabolism; Protein Binding; Protein Isoforms / metabolism; Shelterin Complex / metabolism; Shelterin Complex / physiology; Telomere / metabolism; Telomere-Binding Proteins / metabolism; Telomere-Binding Proteins / physiology; Telomeric Repeat Binding Protein 1 / metabolism; Telomeric Repeat Binding Protein 1 / physiology; Telomeric Repeat Binding Protein 2 / metabolism; Telomeric Repeat Binding Protein 2 / physiology
Sources: Web Of Science, ORCID
Added: October 26, 2021

2021 journal article

Structure, dynamics, and regulation of TRF1-TIN2-mediated trans-and cis-interactions on telomeric DNA

Journal of Biological Chemistry, 101080.

By: H. Pan, P. Kaur, R. Barnes, A. Detwiler, S. Sanford, M. Liu, P. Xu, C. Mahn ...

Source: ORCID
Added: September 23, 2021

2021 journal article

TIN2 is an architectural protein that facilitates TRF2-mediated trans- and cis-interactions on telomeric DNA

NUCLEIC ACIDS RESEARCH, 49(22), 13000–13018.

By: P. Kaur n, R. Barnes*, H. Pan n, A. Detwiler*, M. Liu n, C. Mahn n, J. Hall n, Z. Messenger n ...

co-author countries: Germany 🇩🇪 United States of America 🇺🇸
MeSH headings : Animals; DNA / chemistry; DNA / genetics; DNA / metabolism; HeLa Cells; Humans; Mice, Inbred C57BL; Microscopy, Atomic Force; Nucleic Acid Conformation; Protein Binding; Shelterin Complex / genetics; Shelterin Complex / metabolism; Telomere / genetics; Telomere / metabolism; Telomere-Binding Proteins / genetics; Telomere-Binding Proteins / metabolism; Telomeric Repeat Binding Protein 2 / genetics; Telomeric Repeat Binding Protein 2 / metabolism
Sources: Web Of Science, ORCID
Added: January 18, 2022

2021 journal article

Using Atomic Force Microscopy to Study the Real Time Dynamics of DNA Unwinding by Mitochondrial Twinkle Helicase

BIO-PROTOCOL, 11(17).

By: P. Kaur*, H. Pan*, M. Longley, W. Copeland & H. Wang*

author keywords: Atomic Force Microscope; Twinkle helicase; Mitochondria; Liquid AFM imaging; Mitochondrial replication; Single molecule imaging
Sources: Web Of Science, ORCID
Added: September 20, 2021

2020 journal article

Cohesin SA1 and SA2 are RNA binding proteins that localize to RNA containing regions on DNA

NUCLEIC ACIDS RESEARCH, 48(10), 5639–5655.

By: H. Pan n, M. Jin*, A. Ghadiyaram n, P. Kaur n, H. Miller*, H. Ta*, M. Liu n, Y. Fan* ...

co-author countries: Germany 🇩🇪 United States of America 🇺🇸
MeSH headings : Binding Sites; Cell Cycle Proteins / metabolism; Chromosomal Proteins, Non-Histone / metabolism; DNA / metabolism; R-Loop Structures; RNA / metabolism; RNA-Binding Proteins / metabolism
Sources: Web Of Science, ORCID
Added: October 5, 2020

2020 journal article

Cohesin SA1 and SA2 are RNA binding proteins that localize to RNA containing regions on DNA

Nucleic Acids Research.

By: H. Pan, M. Jin, A. Ghadiyaram, P. Kaur, H. Miller, H. Ta, M. Liu, Y. Fan ...

Source: ORCID
Added: September 23, 2021

2020 journal article

DNA looping by two 5-methylcytosine-binding proteins quantified using nanofluidic devices

EPIGENETICS & CHROMATIN, 13(1).

By: M. Liu n, S. Movahed n, S. Dangi n, H. Pan n, P. Kaur n, S. Bilinovich*, E. Faison*, G. Leighton* ...

co-author countries: United States of America 🇺🇸
author keywords: DNA methylation; MeCP2; MBD2; DNA compaction
MeSH headings : 5-Methylcytosine / chemistry; 5-Methylcytosine / metabolism; Binding Sites; DNA / chemistry; DNA / metabolism; DNA Methylation; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / metabolism; Epigenomics / methods; Humans; Methyl-CpG-Binding Protein 2 / chemistry; Methyl-CpG-Binding Protein 2 / metabolism; Microfluidics / instrumentation; Microfluidics / methods; Microscopy, Atomic Force / methods; Protein Binding
Sources: Web Of Science, ORCID
Added: April 20, 2020

2020 journal article

Single-molecule level structural dynamics of DNA unwinding by human mitochondrial Twinkle helicase

JOURNAL OF BIOLOGICAL CHEMISTRY, 295(17), 5564–5576.

co-author countries: United States of America 🇺🇸
author keywords: atomic force microscopy (AFM); DNA binding protein; DNA helicase; DNA replication; mitochondrial disease; mitochondrial DNA (mtDNA); single-molecule biophysics; ssDNA-binding protein (SSB); structural dynamics; Twinkle helicase
MeSH headings : DNA / analysis; DNA / metabolism; DNA Helicases / analysis; DNA Helicases / metabolism; Humans; Microscopy, Atomic Force; Mitochondria / metabolism; Mitochondrial Proteins / analysis; Mitochondrial Proteins / metabolism; Nucleic Acid Conformation; Protein Binding; Protein Multimerization; Recombinant Proteins / analysis; Recombinant Proteins / metabolism
Source: Web Of Science
Added: May 18, 2020

2020 journal article

Single-molecule level structural dynamics of DNA unwinding by human mitochondrial Twinkle helicase

Journal of Biological Chemistry, 295(17), 5564–5576.

By: P. Kaur, M. Longley, H. Pan, W. Wang, P. Countryman, H. Wang, W. Copeland

Source: ORCID
Added: September 23, 2021

2019 journal article

Cohesin SA2 and EWSR1 in R-Loop Regulation

Biophysical Journal, 116(3), 505a.

By: H. Wang n, A. Ghadiyaram n, H. Pan n, Y. Fan*, P. Kaur n, A. Gorthi*, R. Riehn n, A. Bishop*, Y. Jane Tao*

co-author countries: United States of America 🇺🇸
Sources: Crossref, ORCID
Added: January 25, 2020

2019 article

Measuring UV Photoproduct Repair in Isolated Telomeres and Bulk Genomic DNA

DNA REPAIR: METHODS AND PROTOCOLS, Vol. 1999, pp. 295–306.

co-author countries: United States of America 🇺🇸
author keywords: UV photoproducts; UV irradiation; Telomeres; Immunospot blot; Telomere isolation; Radiolabeled DNA probes
MeSH headings : Antibodies / immunology; Cell Line; DNA / analysis; DNA / genetics; DNA / radiation effects; DNA Damage / radiation effects; DNA Repair; Genomic Instability; Genomics / methods; Humans; Immunoblotting / methods; Pyrimidine Dimers / analysis; Pyrimidine Dimers / genetics; Pyrimidine Dimers / radiation effects; Telomere / genetics; Telomere / immunology; Telomere / radiation effects; Telomere-Binding Proteins / immunology; Ultraviolet Rays / adverse effects
Source: Web Of Science
Added: October 7, 2019

2019 chapter

Measuring UV Photoproduct Repair in Isolated Telomeres and Bulk Genomic DNA

In DNA Repair (pp. 295–306). Springer.

By: E. Fouquerel, R. Barnes, H. Wang & P. Opresko

Source: ORCID
Added: September 23, 2021

2019 journal article

Single-Molecule Study of TRF2 Mediated DNA Compaction using Physiologically Relevant Long Telomeric DNA

Biophysical Journal, 116(3), 505a.

By: P. Kaur n, R. Barnes*, H. Pan n, P. Opresko*, R. Riehn n & H. Wang n

co-author countries: United States of America 🇺🇸
Sources: Crossref, ORCID
Added: January 25, 2020

2019 journal article

TIN2 is an Architectural Protein Stabilizing TRF1 at Telomere

Biophysical Journal, 116(3), 211a–212a.

By: H. Pan n, S. Dangi n, P. Kaur n, P. Hao n, K. Weninger n, R. Riehn n, P. Opresko*, H. Wang n

co-author countries: United States of America 🇺🇸
Sources: Crossref, ORCID
Added: January 25, 2020

2018 journal article

Cohesin SA2 is a sequence-independent DNA-binding protein that recognizes DNA replication and repair intermediates

JOURNAL OF BIOLOGICAL CHEMISTRY, 293(3), 1054–1069.

By: P. Countryman n, Y. Fan*, A. Gorthi*, H. Pan n, J. Strickland n, P. Kaur n, X. Wang n, J. Lin n ...

co-author countries: China 🇨🇳 Germany 🇩🇪 United States of America 🇺🇸
MeSH headings : Cell Cycle Proteins / chemistry; Cell Cycle Proteins / metabolism; Chromosomal Proteins, Non-Histone / chemistry; Chromosomal Proteins, Non-Histone / metabolism; DNA Repair / genetics; DNA Repair / physiology; DNA Replication / physiology; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / metabolism; Fluorescence Polarization; Genomic Instability / genetics; Genomic Instability / physiology; Microscopy, Atomic Force; Microscopy, Fluorescence; Protein Binding / genetics; Protein Binding / physiology
Sources: Web Of Science, ORCID
Added: August 6, 2018

2018 journal article

Single-molecule DREEM imaging reveals DNA wrapping around human mitochondrial single-stranded DNA binding protein

NUCLEIC ACIDS RESEARCH, 46(21), 11287–11302.

By: P. Kaur n, M. Longley*, H. Pan n, H. Wang n & W. Copeland*

co-author countries: United States of America 🇺🇸
MeSH headings : DNA, Mitochondrial / chemistry; DNA, Mitochondrial / metabolism; DNA, Single-Stranded / chemistry; DNA, Single-Stranded / metabolism; DNA-Binding Proteins / analysis; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / metabolism; Fluorescence Polarization; Humans; Microscopy, Atomic Force / methods; Mitochondrial Proteins / analysis; Mitochondrial Proteins / chemistry; Mitochondrial Proteins / metabolism; Protein Conformation; Protein Stability; Recombinant Proteins / genetics; Single Molecule Imaging / methods; Static Electricity
Sources: Web Of Science, ORCID
Added: February 11, 2019

2017 journal article

Cohesin SA2 is a sequence independent DNA binding protein that recognizes DNA replication and repair intermediates

Journal of Biological Chemistry, jbc-M117.

By: P. Countryman, Y. Fan, A. Gorthi, H. Pan, J. Strickland, P. Kaur, X. Wang, J. Lin ...

Source: ORCID
Added: September 23, 2021

2017 journal article

CpG and methylation-dependent DNA binding and dynamics of the methylcytosine binding domain 2 protein at the single-molecule level

NUCLEIC ACIDS RESEARCH, 45(15), 9164–9177.

By: H. Pan n, S. Bilinovich*, P. Kaur n, R. Riehn n, H. Wang n & D. Williams*

co-author countries: United States of America 🇺🇸
MeSH headings : 5-Methylcytosine / chemistry; 5-Methylcytosine / metabolism; Animals; Binding Sites; Chickens; Cloning, Molecular; CpG Islands; DNA / chemistry; DNA / metabolism; DNA Methylation; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Escherichia coli / genetics; Escherichia coli / metabolism; Fluorescence Polarization; Gene Expression; Humans; Magnetic Resonance Spectroscopy; Mi-2 Nucleosome Remodeling and Deacetylase Complex / metabolism; Mi-2 Nucleosome Remodeling and Deacetylase Complex / ultrastructure; Nucleic Acid Conformation; Nucleosomes / metabolism; Nucleosomes / ultrastructure; Protein Binding; Protein Isoforms / chemistry; Protein Isoforms / genetics; Protein Isoforms / metabolism; Recombinant Proteins / chemistry; Recombinant Proteins / genetics; Recombinant Proteins / metabolism; Single Molecule Imaging
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

Nucleosome-like, Single-stranded DNA (ssDNA)-Histone Octamer Complexes and the Implication for DNA Double Strand Break Repair

Journal of Biological Chemistry, 292(13), 5271–5281.

By: N. Adkins, S. Swygert, P. Kaur, H. Niu, S. Grigoryev, P. Sung, H. Wang, C. Peterson

Source: ORCID
Added: September 23, 2021

2017 journal article

Single Molecule Fluorescence and Atomic Force Microscopy Studies of DNA Repair

Biophysical Journal, 112(3), 7a.

By: D. Erie*, K. Bradford*, H. Wilkins*, J. Bower*, Z. Wang*, J. Gauer*, M. Satusky*, R. Qiu n ...

co-author countries: United States of America 🇺🇸
Sources: Crossref, ORCID
Added: February 5, 2020

2017 journal article

Using Atomic Force Microscopy to Characterize the Conformational Properties of Proteins and Protein--DNA Complexes That Carry Out DNA Repair

Methods in Enzymology, 592, 187–212.

By: S. LeBlanc, H. Wilkins, Z. Li, P. Kaur, H. Wang & D. Erie

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2017 journal article

Walking the DNA Methylation Tightrope: The Involvement of Intrinsically Disordered Regions of Transcription Factors

Biophysical Journal, 112(3), 207a.

By: S. Bilinovich*, H. Pan n, P. Kaur n, H. Wang n & D. Williams*

co-author countries: United States of America 🇺🇸
Sources: Crossref, ORCID
Added: February 24, 2020

2016 journal article

Enhanced electrostatic force microscopy reveals higher-order DNA looping mediated by the telomeric protein TRF2

Scientific Reports, 6(1).

By: P. Kaur n, D. Wu n, J. Lin n, P. Countryman n, K. Bradford*, D. Erie*, R. Riehn n, P. Opresko*, H. Wang n

co-author countries: China 🇨🇳 United States of America 🇺🇸
MeSH headings : DNA / chemistry; DNA / metabolism; HeLa Cells; Humans; Microscopy; Multiprotein Complexes / chemistry; Multiprotein Complexes / metabolism; Nucleic Acid Conformation; Static Electricity; Telomeric Repeat Binding Protein 2 / chemistry; Telomeric Repeat Binding Protein 2 / metabolism
Sources: Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2016 journal article

Functional interplay between SA1 and TRF1 in telomeric DNA binding and DNA--DNA pairing

Nucleic Acids Research, gkw518.

By: J. Lin, P. Countryman, H. Chen, H. Pan, Y. Fan, Y. Jiang, P. Kaur, W. Miao ...

Source: ORCID
Added: September 23, 2021

2016 journal article

Functional interplay between SA1 and TRF1 in telomeric DNA binding and DNA-DNA pairing

NUCLEIC ACIDS RESEARCH, 44(13), 6363–6376.

By: J. Lin n, P. Countryman n, H. Chen*, H. Pan n, Y. Fan*, Y. Jiang*, P. Kaur n, W. Miao* ...

co-author countries: China 🇨🇳 Germany 🇩🇪 United Kingdom of Great Britain and Northern Ireland 🇬🇧 United States of America 🇺🇸
MeSH headings : AT-Hook Motifs / genetics; Chromatids / genetics; Chromatids / ultrastructure; Chromosome Segregation / genetics; DNA-Binding Proteins / genetics; Humans; Microscopy, Atomic Force; Mitosis / genetics; Nuclear Proteins / genetics; Nuclear Proteins / metabolism; Telomere / genetics; Telomere / ultrastructure; Telomere-Binding Proteins / genetics; Telomere-Binding Proteins / metabolism; Telomeric Repeat Binding Protein 1 / genetics; Telomeric Repeat Binding Protein 1 / metabolism
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

TRF2-Mediated Control of Telomere DNA Topology as a Mechanism for Chromosome-End Protection

Molecular Cell.

By: D. Benarroch-Popivker, S. Pisano, A. Mendez-Bermudez, L. Lototska, P. Kaur, S. Bauwens, N. Djerbi, C. Latrick ...

Source: ORCID
Added: September 23, 2021

2016 journal article

TRF2-mediated control of telomere DNA topology as a mechanism for chromosome-end protection

Molecular Cell, 61(2), 274–286.

By: D. Benarroch-Popivker, S. Pisano, A. Mendez-Bermudez, L. Lototska, P. Kaur, S. Bauwens, N. Djerbi, C. Latrick ...

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Visualizing the Path of DNA through Proteins Using DREEM Imaging

MOLECULAR CELL, 61(2), 315–323.

By: D. Wu*, P. Kaur n, Z. Li*, K. Bradford*, H. Wang n & D. Erie*

co-author countries: United States of America 🇺🇸
MeSH headings : DNA / chemistry; DNA Mismatch Repair; Imaging, Three-Dimensional; Microscopy, Atomic Force; Nucleosomes / metabolism; Proteins / metabolism; Static Electricity
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

Determining the DNA Diffusion Behavior of SA2 on Various DNA Substrates

Biophysical Journal, 108(2), 397a.

By: P. Countryman n, J. Lin n, P. Kaur n, E. Brennan n, H. Chen*, C. You*, J. Piehler*, Y. Tao*, H. Wang n

co-author countries: Germany 🇩🇪 United States of America 🇺🇸
Sources: Crossref, ORCID
Added: February 24, 2020

2015 journal article

Interference of ATP with the fluorescent probes YOYO-1 and YOYO-3 modifies the mechanical properties of intercalator-stained DNA confined in nanochannels

Microchimica Acta, 182(7-8), 1561–1565.

By: M. Roushan n, Z. Azad n, S. Lim n, H. Wang n & R. Riehn n

co-author countries: United States of America 🇺🇸

Contributors: M. Roushan n, Z. Azad n, S. Lim n, H. Wang n & R. Riehn n

author keywords: DNA; ATP; Intercalating dye; YOYO-1; DAPI; Nanofluidics
Sources: Crossref, Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

Revealing Structure and Dynamics of Telomere Maintenance Proteins on DNA: One Molecule at a Time

Biophysical Journal, 108(2), 7a.

By: H. Wang n, J. Lin n, P. Kaur n, P. Countryman n, P. Opresko*, S. Smith, J. Tao*

co-author countries: United States of America 🇺🇸
Sources: Crossref, ORCID
Added: February 24, 2020

2015 journal article

Single-Molecule Imaging Reveals Dynamics of SA1-TRF1 Interactions on Telomeric DNA

Biophysical Journal, 108(2), 206a.

By: J. Lin n, H. Chen*, P. Kaur n, W. Miao n, P. Countryman n, C. You*, J. Piehler*, Y. Tao*, S. Smith*, H. Wang n

co-author countries: Germany 🇩🇪 United States of America 🇺🇸
Sources: Crossref, ORCID
Added: February 24, 2020

2015 journal article

Telomeres are partly shielded from ultraviolet-induced damage and proficient for nucleotide excision repair of photoproducts

NATURE COMMUNICATIONS, 6.

By: D. Parikh*, E. Fouquerel*, C. Murphy*, H. Wang n & P. Opresko n

co-author countries: United States of America 🇺🇸
MeSH headings : Cell Line; Cell Proliferation; Cell Survival; DNA Damage / radiation effects; DNA Repair / physiology; Fibroblasts / cytology; Fibroblasts / radiation effects; Humans; Telomere / radiation effects; Ultraviolet Rays
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

Probing transient protein-mediated DNA linkages using nanoconfinement

Biomicrofluidics, 8(3), 034113.

By: M. Roushan n, P. Kaur n, A. Karpusenko n, P. Countryman n, C. Ortiz n, S. Fang Lim n, H. Wang n, R. Riehn n

co-author countries: United States of America 🇺🇸

Contributors: M. Roushan n, P. Kaur n, A. Karpusenko n, P. Countryman n, C. Ortiz n, S. Lim n, H. Wang n, R. Riehn n

Sources: Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2014 journal article

Single-molecule analysis reveals human UV-damaged DNA-binding protein (UV-DDB) dimerizes on DNA via multiple kinetic intermediates

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111(18), E1862–E1871.

By: H. Ghodke*, H. Wang n, C. Hsieh*, S. Woldemeskel*, S. Watkins*, V. Rapic-Otrin*, B. Van Houten*

co-author countries: United States of America 🇺🇸
author keywords: DNA damage recognition; single-molecule tracking; DNA tightrope; human nucleotide excision repair
MeSH headings : Amino Acid Substitution; DNA / chemistry; DNA / metabolism; DNA / radiation effects; DNA Damage; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Humans; Kinetics; Microscopy, Fluorescence; Models, Molecular; Mutagenesis, Site-Directed; Nucleic Acid Conformation; Osmolar Concentration; Protein Conformation; Protein Multimerization; Pyrimidine Dimers / metabolism; Pyrimidine Dimers / radiation effects; Quantum Dots; Ultraviolet Rays / adverse effects; Xeroderma Pigmentosum / genetics; Xeroderma Pigmentosum / metabolism
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 conference paper

Single-molecule imaging reveals DNA-binding properties of cohesin proteins SA1 and SA2.

Environmental and Molecular Mutagenesis, 55, S29–29.

By: J. Lin, P. Kaur, H. Chen, P. Countryman, M. Roushan, D. Flaherty, E. Brennan, C. You ...

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

TRF1 and TRF2 use different mechanisms to find telomeric DNA but share a novel mechanism to search for protein partners at telomeres

NUCLEIC ACIDS RESEARCH, 42(4), 2493–2504.

By: J. Lin n, P. Countryman n, N. Buncher n, P. Kaur n, E. Longjiang n, Y. Zhang n, G. Gibson n, C. You n ...

co-author countries: United States of America 🇺🇸
MeSH headings : DNA / chemistry; DNA / metabolism; Diffusion; Protein Binding; Protein Structure, Tertiary; Repetitive Sequences, Nucleic Acid; Telomere / chemistry; Telomere / metabolism; Telomeric Repeat Binding Protein 1 / metabolism; Telomeric Repeat Binding Protein 2 / chemistry; Telomeric Repeat Binding Protein 2 / metabolism
Source: Web Of Science
Added: August 6, 2018

2014 journal article

TRF1 and TRF2 use different mechanisms to find telomeric DNA but share a novel mechanism to search for protein partners at telomeres

Nucleic Acids Research, 42(4), 2493–2504.

By: J. Lin, P. Countryman, N. Buncher, P. Kaur, E. Longjiang, Y. Zhang, G. Gibson, C. You ...

Source: ORCID
Added: September 23, 2021

2014 journal article

Unraveling secrets of telomeres: One molecule at a time

DNA REPAIR, 20, 142–153.

By: J. Lin n, P. Kaur n, P. Countryman n, P. Opresko* & H. Wang n

co-author countries: United States of America 🇺🇸
author keywords: Telomeres; Single-molecule imaging; Atomic force microscopy; Fluorescence microscopy; FRET; Laser tweezers; Magnetic tweezers; Protein DNA interactions
MeSH headings : Animals; Fluorescence Resonance Energy Transfer / methods; Humans; Microscopy, Atomic Force / methods; Microscopy, Fluorescence / methods; Optical Tweezers; Telomere / chemistry; Telomere / metabolism; Telomere-Binding Proteins / chemistry; Telomere-Binding Proteins / metabolism
Sources: Web Of Science, ORCID
Added: August 6, 2018

2013 journal article

DNA polymerase delta stalls on telomeric lagging strand templates independently from G-quadruplex formation

NUCLEIC ACIDS RESEARCH, 41(22), 10323–10333.

By: J. Lormand n, N. Buncher n, C. Murphy n, P. Kaur n, M. Lee n, P. Burgers n, H. Wang n, T. Kunkel n, P. Opresko n

co-author countries: United States of America 🇺🇸
MeSH headings : DNA / biosynthesis; DNA / chemistry; DNA Polymerase III / metabolism; G-Quadruplexes; Humans; Repetitive Sequences, Nucleic Acid; Telomere / metabolism; Templates, Genetic
Sources: Web Of Science, ORCID
Added: August 6, 2018

2013 review

Investigating bioconjugation by atomic force microscopy

[Review of ]. Journal of Anobiotechnology, 11.

By: I. Tessmer, P. Kaur, J. Lin & H. Wang

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

Investigating bioconjugation by atomic force microscopy

J. Nanobiotechnol, 11, 25.

By: I. Tessmer, P. Kaur, J. Lin & H. Wang

Source: ORCID
Added: September 23, 2021

2013 journal article

Real-time single-molecule imaging reveals a direct interaction between UvrC and UvrB on DNA tightropes

Nucleic Acids Research, gkt177.

By: C. Hughes, H. Wang, H. Ghodke, M. Simons, A. Towheed, Y. Peng, B. Van Houten, N. Kad

Source: ORCID
Added: September 23, 2021

2013 journal article

WT UV-DDB Performs a 3D Search on DNA whereas the XP-E Mutant (K244E DDB2) Mutant Slides

Biophysical Journal, 104(2), 77a.

By: H. Ghodke*, H. Wang n, C. Hsieh*, G. Gibson*, S. Watkins*, V. Rapic-Otrin*, A. Levine*, B. Van Houten*

co-author countries: United States of America 🇺🇸
Sources: Crossref, ORCID
Added: December 12, 2021

2012 journal article

A New Role for UvrB in NER? Single Molecule Imaging of the NER Complex UvrBC-DNA

Biophysical Journal, 102(3), 485a.

By: C. Hughes*, M. Towheed*, M. Simons*, H. Wang*, B. Van Houten* & N. Kad*

co-author countries: United Kingdom of Great Britain and Northern Ireland 🇬🇧 United States of America 🇺🇸
Sources: Crossref, ORCID
Added: December 12, 2021

2012 journal article

Damaged DNA induced UV-damaged DNA-binding protein (UV-DDB) dimerization and its roles in chromatinized DNA repair

Proceedings of the National Academy of Sciences, 109(41), E2737–E2746.

By: J. Yeh*, A. Levine*, S. Du, U. Chinte, H. Ghodke, H. Wang*, H. Shi, C. Hsieh* ...

co-author countries: Russian Federation 🇷🇺 United States of America 🇺🇸
author keywords: UV damage; ubiquitin-proteosome system; X-ray crystallography
MeSH headings : Chromatin / chemistry; Chromatin / genetics; Chromatin / metabolism; Crystallography, X-Ray; Cullin Proteins / chemistry; Cullin Proteins / metabolism; DNA / chemistry; DNA / genetics; DNA / metabolism; DNA Damage; DNA Repair; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / metabolism; Humans; Microscopy, Atomic Force; Microscopy, Electron; Models, Molecular; Multiprotein Complexes / chemistry; Multiprotein Complexes / metabolism; Multiprotein Complexes / ultrastructure; Nucleic Acid Conformation; Protein Binding; Protein Folding; Protein Multimerization; Protein Structure, Secondary; Protein Structure, Tertiary
Sources: Crossref, ORCID
Added: September 23, 2021

2012 journal article

Werner syndrome protein suppresses the formation of large deletions during the replication of human telomeric sequences

Cell Cycle, 11(16), 3036–3044.

By: R. Damerla, K. Knickelbein, S. Strutt, F. Liu, H. Wang & P. Opresko

Source: ORCID
Added: September 23, 2021

2011 journal article

High accuracy FIONA–AFM hybrid imaging

Ultramicroscopy, 111(5), 350–355.

By: D. Fronczek*, C. Quammen*, H. Wang*, C. Kisker*, R. Superfine*, R. Taylor*, D. Erie*, I. Tessmer*

co-author countries: Germany 🇩🇪 United States of America 🇺🇸
author keywords: Atomic force microscopy (AFM); Fluorescence imaging with one nanometer accuracy (FIONA); Single molecule; Multi-protein complexes; Image registration
MeSH headings : Bacillus / chemistry; Bacterial Proteins / chemistry; Microscopy, Atomic Force / methods; Microscopy, Fluorescence / methods; Quantum Dots
Sources: Crossref, ORCID
Added: September 23, 2021

2011 journal article

Investigating Nucleotide Excision DNA Repair by Single-Molecule Imaging of Quantum Dot Labeled Proteins Reveals Unique Scanning Mechanisms

Biophysical Journal, 100(3), 240a.

By: R. Keller, H. Wang*, M. Towheed, B. Van Houten & N. Kad

Sources: Crossref, ORCID
Added: December 12, 2021

2011 chapter

Nucleotide excision repair from bacteria to humans: Structure--function studies

In Chemical Carcinogenesis (pp. 267–296). Springer.

By: Y. Peng, H. Wang, L. Santana-Santos, C. Kisker & B. Van Houten

Source: ORCID
Added: September 23, 2021

2011 journal article

Single Molecule Studies of Physiologically Relevant Telomeric Tails Reveal POT1 Mechanism for Promoting G-quadruplex Unfolding

Journal of Biological Chemistry, 286(9), 7479–7489.

By: H. Wang*, G. Nora*, H. Ghodke* & P. Opresko*

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Cell Line; Combinatorial Chemistry Techniques; DNA, Single-Stranded / chemistry; G-Quadruplexes; Humans; Insecta; Microscopy, Atomic Force; Models, Chemical; Oligonucleotides, Antisense; Protein Binding; Shelterin Complex; Telomere / chemistry; Telomere / genetics; Telomere / metabolism; Telomere-Binding Proteins / chemistry; Telomere-Binding Proteins / genetics; Telomere-Binding Proteins / metabolism
Sources: Crossref, ORCID
Added: September 23, 2021

2010 journal article

Collaborative Dynamic DNA Scanning by Nucleotide Excision Repair Proteins Investigated by Single- Molecule Imaging of Quantum-Dot-Labeled Proteins

Molecular Cell, 37(5), 702–713.

By: N. Kad*, H. Wang*, G. Kennedy*, D. Warshaw* & B. Van Houten*

co-author countries: United Kingdom of Great Britain and Northern Ireland 🇬🇧 United States of America 🇺🇸
MeSH headings : Adenosine Triphosphatases / chemistry; Adenosine Triphosphatases / genetics; Adenosine Triphosphatases / metabolism; Adenosine Triphosphate / metabolism; Binding Sites; DNA / chemistry; DNA / metabolism; DNA Helicases / chemistry; DNA Helicases / genetics; DNA Helicases / metabolism; DNA Repair; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Electrophoretic Mobility Shift Assay; Escherichia coli Proteins / chemistry; Escherichia coli Proteins / genetics; Escherichia coli Proteins / metabolism; Kinetics; Microscopy, Atomic Force; Microscopy, Fluorescence; Models, Molecular; Nucleic Acid Conformation; Protein Binding; Protein Conformation; Protein Multimerization; Quantum Dots
Sources: Crossref, ORCID
Added: September 23, 2021

2009 journal article

Replication Protein A Stimulates the Werner Syndrome Protein Branch Migration Activity

Journal of Biological Chemistry, 284(50), 34682–34691.

By: G. Sowd*, H. Wang*, D. Pretto*, W. Chazin* & P. Opresko*

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; DNA Replication; DNA, Single-Stranded / chemistry; DNA, Single-Stranded / genetics; DNA, Single-Stranded / metabolism; Exodeoxyribonucleases / genetics; Exodeoxyribonucleases / metabolism; Humans; Nucleic Acid Conformation; RecQ Helicases / genetics; RecQ Helicases / metabolism; Recombination, Genetic; Replication Protein A / genetics; Replication Protein A / metabolism; Shelterin Complex; Telomere / metabolism; Telomere-Binding Proteins / genetics; Telomere-Binding Proteins / metabolism; Werner Syndrome / genetics; Werner Syndrome / metabolism; Werner Syndrome Helicase
Sources: Crossref, ORCID
Added: September 23, 2021

2009 journal article

The Werner syndrome helicase/exonuclease processes mobile D-loops through branch migration and degradation

PLoS One, 4(3), e4825.

By: P. Opresko, G. Sowd & H. Wang

Source: ORCID
Added: September 23, 2021

2008 journal article

Efficient processing of TFO-directed psoralen DNA interstrand crosslinks by the UvrABC nuclease

Nucleic Acids Research, 36(22), 7136–7145.

By: L. Christensen, H. Wang, B. Van Houten & K. Vasquez

Source: ORCID
Added: September 23, 2021

2008 journal article

Functional Characterization and Atomic Force Microscopy of a DNA Repair Protein Conjugated to a Quantum Dot

Nano Letters, 8(6), 1631–1637.

co-author countries: United States of America 🇺🇸
MeSH headings : Binding Sites; DNA Repair Enzymes / chemistry; DNA Repair Enzymes / ultrastructure; Microscopy, Atomic Force / methods; Protein Binding; Protein Interaction Mapping / methods; Quantum Dots
Sources: Crossref, ORCID
Added: September 23, 2021

2007 chapter

Characterization of protein--protein interactions using atomic force microscopy

In Protein Interactions (pp. 39–77). Springer.

By: H. Wang, Y. Yang & D. Erie

Source: ORCID
Added: September 23, 2021

2006 journal article

Structural basis for DNA recognition and processing by UvrB

Nature Structural & Molecular Biology, 13(4), 360–364.

By: J. Truglio*, E. Karakas*, B. Rhau*, H. Wang*, M. DellaVecchia*, B. Van Houten*, C. Kisker*

co-author countries: Germany 🇩🇪 United States of America 🇺🇸
MeSH headings : Bacillus / genetics; Bacillus / metabolism; Bacterial Proteins / chemistry; Bacterial Proteins / metabolism; Base Sequence; Crystallography, X-Ray; DNA Damage; DNA Repair; DNA, Bacterial / chemistry; DNA, Bacterial / genetics; DNA, Bacterial / metabolism; Macromolecular Substances; Models, Molecular; Static Electricity
Sources: Crossref, ORCID
Added: September 23, 2021

2006 journal article

The C-terminal Zinc Finger of UvrA Does Not Bind DNA Directly but Regulates Damage-specific DNA Binding

Journal of Biological Chemistry, 281(36), 26370–26381.

By: D. Croteau*, M. DellaVecchia*, H. Wang*, R. Bienstock*, M. Melton* & B. Van Houten*

co-author countries: United States of America 🇺🇸
MeSH headings : Adenosine Triphosphatases / chemistry; Adenosine Triphosphatases / genetics; Adenosine Triphosphatases / metabolism; Adenosine Triphosphate / metabolism; Amino Acid Sequence; DNA / metabolism; DNA Damage; DNA Helicases / genetics; DNA Helicases / metabolism; DNA Repair; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Dimerization; Escherichia coli / genetics; Escherichia coli / metabolism; Escherichia coli Proteins / chemistry; Escherichia coli Proteins / genetics; Escherichia coli Proteins / metabolism; Magnesium / metabolism; Models, Molecular; Molecular Sequence Data; Mutation; Protein Binding; Protein Structure, Quaternary; Protein Structure, Secondary; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / metabolism; Sequence Alignment; Ultraviolet Rays; Zinc Fingers
Sources: Crossref, ORCID
Added: September 23, 2021

2006 journal article

UvrB Domain 4, an Autoinhibitory Gate for Regulation of DNA Binding and ATPase Activity

Journal of Biological Chemistry, 281(22), 15227–15237.

By: H. Wang*, M. DellaVecchia*, M. Skorvaga*, D. Croteau*, D. Erie* & B. Van Houten*

co-author countries: Slovakia 🇸🇰 United States of America 🇺🇸
MeSH headings : Adenosine Triphosphatases / genetics; Adenosine Triphosphatases / metabolism; Amino Acid Sequence; Bacillus / genetics; Bacillus / metabolism; Bacterial Proteins / chemistry; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Base Sequence; DNA Damage; DNA Repair; DNA, Bacterial / genetics; DNA, Bacterial / metabolism; Dimerization; Kinetics; Models, Biological; Molecular Sequence Data; Protein Structure, Quaternary; Protein Structure, Tertiary; Sequence Homology, Amino Acid
Sources: Crossref, ORCID
Added: September 23, 2021

2005 journal article

Structural insights into the first incision reaction during nucleotide excision repair

The EMBO Journal, 24(5), 885–894.

By: J. Truglio*, B. Rhau*, D. Croteau*, L. Wang*, M. Skorvaga*, E. Karakas*, M. DellaVecchia*, H. Wang*, B. Van Houten*, C. Kisker*

co-author countries: Slovakia 🇸🇰 United States of America 🇺🇸
author keywords: crystallography; DNA damage; DNA repair; nucleotide excision repair; UvrC
MeSH headings : Amino Acid Sequence; Bacillus / enzymology; Bacillus / genetics; Catalytic Domain / genetics; Cations, Divalent / metabolism; Conserved Sequence; Crystallography, X-Ray; DNA Repair / physiology; DNA, Bacterial / chemistry; DNA, Bacterial / metabolism; Endodeoxyribonucleases / chemistry; Endodeoxyribonucleases / genetics; Endodeoxyribonucleases / metabolism; Escherichia coli Proteins; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Structure, Tertiary; Recombinant Proteins / chemistry; Recombinant Proteins / genetics; Recombinant Proteins / metabolism; Sequence Homology, Amino Acid; Static Electricity
Source: Crossref
Added: December 12, 2021

2005 journal article

Structural insights into the first incision reaction during nucleotide excision repair

The EMBO Journal, 24(5), 885–894.

By: J. Truglio, B. Rhau, D. Croteau, L. Wang, M. Skorvaga, E. Karakas, M. DellaVecchia, H. Wang, B. Van Houten, C. Kisker

Source: ORCID
Added: September 23, 2021

2005 journal article

‘Close-fitting sleeves’: DNA damage recognition by the UvrABC nuclease system

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 577(1-2), 92–117.

By: B. Van Houten*, D. Croteau*, M. DellaVecchia*, H. Wang* & C. Kisker*

co-author countries: United States of America 🇺🇸
author keywords: protein-DNA interaction; bacterial nucleotide excision repair; DNA damage recognition
MeSH headings : DNA Damage; Endodeoxyribonucleases / chemistry; Endodeoxyribonucleases / genetics; Endodeoxyribonucleases / metabolism; Escherichia coli Proteins / chemistry; Escherichia coli Proteins / genetics; Escherichia coli Proteins / metabolism; Models, Molecular; Substrate Specificity
Sources: Crossref, ORCID
Added: September 23, 2021

2003 journal article

DNA bending and unbending by MutS govern mismatch recognition and specificity

Proceedings of the National Academy of Sciences, 100(25), 14822–14827.

By: H. Wang, Y. Yang, M. Schofield, C. Du, Y. Fridman, S. Lee, E. Larson, J. Drummond ...

Source: ORCID
Added: September 23, 2021

2003 journal article

Functional oligomeric state of avian sarcoma virus integrase

Journal of Biological Chemistry, 278(2), 1323–1327.

By: K. Bao, H. Wang, J. Miller, D. Erie, A. Skalka & I. Wong

Source: ORCID
Added: September 23, 2021

2003 journal article

Quantitative characterization of biomolecular assemblies and interactions using atomic force microscopy

Methods, 29(2), 175–187.

By: Y. Yang, H. Wang & D. Erie

Source: ORCID
Added: September 23, 2021

2002 journal article

A minimal exonuclease domain of WRN forms a hexamer on DNA and possesses both 3'-5'exonuclease and 5'-protruding strand endonuclease activities

Biochemistry, 41(9), 2901–2912.

By: Y. Xue, G. Ratcliff, H. Wang, P. Davis-Searles, M. Gray, D. Erie, M. Redinbo

Source: ORCID
Added: September 23, 2021

2002 journal article

DNA binding properties of the yeast Msh2-Msh6 and Mlh1-Pms1 heterodimers

Biological Chemistry, 383(6), 969–975.

By: K. Drotschmann, M. Hall, P. Shcherbakova, H. Wang, D. Erie, F. Brownewell, E. Kool, T. Kunkel

Source: ORCID
Added: September 23, 2021

2001 journal article

High affinity cooperative DNA binding by the yeast Mlh1-Pms1 heterodimer

Journal of Molecular Biology, 312(4), 637–647.

By: M. Hall, H. Wang, D. Erie & T. Kunkel

Source: ORCID
Added: September 23, 2021