Ian Huntress

Dept Molecular Biomedical Scie

Works (2)

Updated: June 17th, 2023 22:23

2022 journal article

Coupling high-throughput mapping with proteomics analysis delineates cis-regulatory elements at high resolution

NUCLEIC ACIDS RESEARCH, 50(1).

By: T. Wu*, D. Jiang*, M. Zou*, W. Sun*, D. Wu, J. Cui*, I. Huntress n, X. Peng n, G. Li*

MeSH headings : Chromosome Mapping / methods; Gene Expression Regulation; Genome, Human; High-Throughput Nucleotide Sequencing / methods; Humans; Regulatory Sequences, Nucleic Acid
TL;DR: The utility of Reel-seq and FREP-MS analyses for the systematic identification of cis-REs at high resolution over a large region of the human genome in a systematic and continuous manner is confirmed. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: February 14, 2022

2021 journal article

Tumor Necrosis Factor Alpha-Induced Interleukin-1 Alpha Synthesis and Cell Death Is Increased in Mouse Epithelial Cells Infected With Chlamydia muridarum

JOURNAL OF INFECTIOUS DISEASES, 224, S47–S55.

By: U. Nagarajan*, C. Cho*, C. Gyorke*, S. Nagarajan*, J. Ezzell*, H. Brochu n, I. Huntress n, E. Harrell n, X. Peng n

author keywords: Chlamydia muridarum; IL-1 alpha; mouse epithelial cells; mouse model; TNF alpha
MeSH headings : Animals; Cell Death; Chlamydia Infections / immunology; Chlamydia Infections / metabolism; Chlamydia muridarum / immunology; Epithelial Cells; Female; Interleukin-1alpha / immunology; Interleukin-1alpha / metabolism; Mice; Mice, Inbred C57BL; Tumor Necrosis Factor-alpha / immunology; Tumor Necrosis Factor-alpha / metabolism
TL;DR: The results suggest TNFα and IL-1α enhance each other's downstream effects resulting in a hyperinflammatory response to chlamydial infection and propose that biologics targeting TNF-induced IL- 1α synthesis could be used to mitigate tissue damage during chlamYDial infection. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: September 13, 2021

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