Il Hwan An

Works (2)

Updated: July 5th, 2023 15:42

2015 article

Rapid synthesis and antimicrobial activity of novel 4-oxazolidinone heterocycles

Shymanska, N. V., An, I. H., Guevara-Zuluaga, S., & Pierce, J. G. (2015, June 12). Bioorganic & Medicinal Chemistry Letters, Vol. 25, pp. 4887–4889.

By: N. Shymanska n, I. An n, S. Guevara-Zuluaga  n & J. Pierce n 

author keywords: Antibiotic; Heterocycle; Oxazolidinone; Natural products
MeSH headings : Acinetobacter baumannii / drug effects; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Dose-Response Relationship, Drug; Microbial Sensitivity Tests; Molecular Structure; Oxazolidinones / chemical synthesis; Oxazolidinones / chemistry; Oxazolidinones / pharmacology; Staphylococcus aureus / drug effects; Structure-Activity Relationship
topics (OpenAlex): Microbial Natural Products and Biosynthesis; Synthesis and Catalytic Reactions; Click Chemistry and Applications
TL;DR: These studies revealed the importance of an electron deficient aromatic ring for antimicrobial activity and serve as the basis for future SAR studies around the 4-oxazolidinone core. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 article

Small-Molecule Suppression of β-Lactam Resistance in Multidrug-Resistant Gram-Negative Pathogens

Brackett, C. M., Melander, R. J., An, I. H., Krishnamurthy, A., Thompson, R. J., Cavanagh, J., & Melander, C. (2014, August 19). Journal of Medicinal Chemistry.

By: C. Brackett n, R. Melander n, I. An n, A. Krishnamurthy n, R. Thompson n, J. Cavanagh n, C. Melander n

MeSH headings : Animals; Cell Line; Cell Survival / drug effects; Drug Resistance, Multiple, Bacterial / drug effects; Gram-Negative Bacteria / classification; Gram-Negative Bacteria / drug effects; Hemolysis / drug effects; Humans; Keratinocytes / cytology; Keratinocytes / drug effects; Microbial Sensitivity Tests; Sheep; Small Molecule Libraries / chemistry; Small Molecule Libraries / pharmacology; beta-Lactam Resistance / drug effects
topics (OpenAlex): Antibiotic Resistance in Bacteria; Cancer therapeutics and mechanisms; Antibiotics Pharmacokinetics and Efficacy
TL;DR: A small molecule was identified from this library of aryl amide 2-aminoimidazoles that is capable of lowering the minimum inhibitory concentration of β-lactam antibiotics by up to 64-fold. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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