Isabel M Gimeno

Works (77)

Updated: April 8th, 2024 08:24

2024 article

Evaluation of Adjuvant Effect of Cytosine-Guanosine-Oligodeoxynucleotide in Meat-Type Chickens Coadministered <i>In Ovo</i> with Herpesvirus of Turkey Vaccine

Boone, A. C., Kulkarni, R. R., Cortes, A. L., Gaghan, C., Mohammed, J., Villalobos, T., … Gimeno, I. M. (2024, February 1). VIRAL IMMUNOLOGY, Vol. 2.

By: A. Boone n, R. Kulkarni  n, A. Cortes n, C. Gaghan n, J. Mohammed*, T. Villalobos*, J. Esandi*, I. Gimeno n 

author keywords: herpesvirus of turkey; toll-like receptor 21; cellular immunity; immunocompetence; in ovo vaccination; chickens
TL;DR: Adding cytosine-guanosine oligodeoxynucleotides (CpG ODNs) to the HVT vaccine could enhance the adjuvant effect of HVT, and CpG ODN administration in ovo with or without HVT significantly increased frequencies of activated CD4+ and CD8+ T cells. (via Semantic Scholar)
Sources: ORCID, Web Of Science
Added: February 2, 2024

2024 article

Optimizing protocols for monitoring <i>in vivo</i> replication of a novel chimeric Marek's disease vaccine with an insertion of the long terminal repeat of reticuloendotheliosis virus in the CVI988 strain genome (CVI-LTR)

Faiz, N. M., Cortes, A. L., Phang, Y.-fun, & Gimeno, I. M. (2024, March 21). AVIAN PATHOLOGY, Vol. 3.

By: N. Faiz*, A. Cortes n, Y. Phang & I. Gimeno n 

author keywords: Marek's disease; vaccines; monitoring; feather pulp; lymphoid organs; LTR
Sources: Web Of Science, ORCID
Added: April 1, 2024

2023 journal article

Effect of CpG-Oligonucleotide in Enhancing Recombinant Herpes Virus of Turkey-Laryngotracheitis Vaccine-Induced Immune Responses in One-Day-Old Broiler Chickens

VACCINES, 11(2).

By: C. Gaghan n, M. Browning n, A. Cortes n, I. Gimeno n  & R. Kulkarni  n

author keywords: infectious laryngotracheitis; CpG-ODN; adjuvant; immune response; chickens
TL;DR: Findings suggested that CpG-ODN can boost rHVT-LT-induced immune responses in day-old chicks, which may help in anti-ILT defense during their later stages of life. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: January 31, 2023

2023 journal article

In Ovo Vaccination with Recombinant Herpes Virus of the Turkey-Laryngotracheitis Vaccine Adjuvanted with CpG-Oligonucleotide Provides Protection against a Viral Challenge in Broiler Chickens

VIRUSES-BASEL, 15(10).

By: C. Gaghan n, M. Browning n, A. Fares n , M. Abdul-Careem*, I. Gimeno n  & R. Kulkarni  n

author keywords: infectious laryngotracheitis; vaccine; protection; CpG oligonucleotide; adjuvant; chickens
TL;DR: It is suggested that CpG-ODN can be used as an effective adjuvant for rHVT-LT in ovo vaccination to induce protective immunity against ILT in broiler chickens. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, ORCID
Added: October 18, 2023

2023 journal article

In ovo HVT vaccination enhances cellular responses at hatch and addition of poly I:C offers minimal adjuvant effects

VACCINE, 41(15), 2514–2523.

By: A. Boone n, R. Kulkarni  n, A. Cortes n, T. Villalobos*, J. Esandi* & I. Gimeno n 

author keywords: Herpesvirus of turkey; Toll -like receptor 3; Innate and Cellular immunity; Immunocompetence; In ovo vaccination; Chickens
MeSH headings : Animals; Chickens; Poly I-C / pharmacology; Toll-Like Receptor 3; Interleukin-13; CD28 Antigens; Marek Disease; Herpesvirus 1, Meleagrid; Interferon-gamma; Vaccination / veterinary
TL;DR: The cellular mechanisms by which HVT-RD can hasten immunocompetence in one-day-old meat-type chickens are evaluated, and it is determined if HVT adjuvantation with a TLR3 agonist, polyinosinic-polycytidylic acid (poly(I:C)), could enhance vaccine-induced responses and provide dose-sparing effects. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: March 8, 2023

2021 article

Characterization of Md5-BAC-REV-LTR virus as Marek's disease vaccine in commercial meat-type chickens: protection and immunosuppression

Ellington, C., Cortes, A. L., Faiz, N. M., Mays, J. K., Fadly, A., Silva, R. F., & Gimeno, I. M. (2021, October 9). AVIAN PATHOLOGY, Vol. 10.

By: C. Ellington n, A. Cortes n, N. Faiz n, J. Mays, A. Fadly, R. Silva, I. Gimeno n 

author keywords: Marek's disease; vaccination; immunosuppression; LTR; recombinant vaccines; control
MeSH headings : Animals; Chickens; Herpesvirus 2, Gallid; Immunosuppression Therapy / veterinary; Marek Disease Vaccines / genetics; Meat; Reticuloendotheliosis virus; Terminal Repeat Sequences / genetics
TL;DR: It is shown that Md5-BAC-REV-LTR has the potential to be used as a MD vaccine and is highly protective against early challenge with vv+ MDV in commercial meat-type chickens. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: October 26, 2021

2021 journal article

Cytokine expression in the eye and brain of chickens following infection with a very virulent plus Marek's disease virus strain

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 237.

By: C. Salvador, A. Cortes*, A. Pandiri & I. Gimeno* 

author keywords: Cytokine; Eye; Brain; Transient paralysis; Chicken
MeSH headings : Animals; Brain / immunology; Brain / pathology; Chickens; Cytokines / biosynthesis; Eye / immunology; Eye / pathology; Herpesvirus 2, Gallid / pathogenicity; Marek Disease / immunology; Marek Disease / pathology; Nervous System Diseases / immunology; Nervous System Diseases / pathology; Nervous System Diseases / veterinary; Nervous System Diseases / virology; Transcriptome; Virulence
TL;DR: The results suggest that MDV elicits different immune responses in the brain and in the eyes of infected chickens, and further studies on the pathogenesis of MDV in the eye could greatly contribute to the authors' knowledge on the chicken eye immunity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science
Added: June 3, 2021

2021 journal article

Replication of Marek's disease vaccines in turkey embryos and their effect on TLR-3 and IFN-gamma transcripts

AVIAN PATHOLOGY, 50(3), 227–233.

By: I. Gimeno n , W. Shaw n, A. Turner n, J. Bremen n, A. Cortes n, N. Faiz n, E. Gonder, K. Robbins*

author keywords: HVT; TLR-3; IFN-&#947; turkey; in ovo; vaccination
TL;DR: It was demonstrated that commercial turkey flocks got exposed to wild type HVT within the first days of life; therefore, there is a potential of interaction between wildtype HVT and rHVT when administered at day of age, and all evaluated vaccines replicated very well in turkey embryonic tissues. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: April 5, 2021

2021 journal article

The role of Meq-vIL8 in regulating Marek's disease virus pathogenesis

JOURNAL OF GENERAL VIROLOGY, 102(2).

By: Y. Liao *, K. Bajwa*, M. Al-Mahmood*, I. Gimeno n , S. Reddy* & B. Lupiani*

author keywords: Marek's disease virus; Meq-vIL8; viral replication; pathogenesis; persistent neurological disease
MeSH headings : Animals; Cells, Cultured; Chick Embryo; DNA, Viral / genetics; Fluorescent Antibody Technique, Indirect; Herpesvirus 2, Gallid / genetics; Herpesvirus 2, Gallid / metabolism; Oncogene Proteins, Viral / genetics; Oncogene Proteins, Viral / metabolism; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / metabolism; Transfection; Virulence Factors; Virus Replication
TL;DR: This study shows that Meq-vIL8 is an important virulence factor of MDV, and generates a recombinant MDV (MDV-meqΔSD) by mutating the splice donor site in the meq gene to abrogate the expression of Meq. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science
Added: November 26, 2020

2020 journal article

In ovo vaccination with herpesvirus of turkey enhances innate and cellular responses in meat-type chickens: Effect of vaccine dose and strain

VACCINE, 38(31), 4837–4845.

By: A. Boone n, T. Kaser  n, A. Cortes n, R. Kulkarni  n, B. Abad  n, T. Villalobos*, J. Esandi*, F. Perozo*, S. Lemiere *, I. Gimeno n 

author keywords: Herpesvirus of turkey; Immunocompetence; In ovo vaccination; Chickens
MeSH headings : Animals; Chick Embryo; Chickens; Herpesvirus 1, Meleagrid; Marek Disease; Meat; Poultry Diseases / prevention & control; Vaccination; Viral Vaccines
TL;DR: It is demonstrated in ovo vaccination with HVT in meat-type chickens can accelerate innate and adaptive immunity and one could optimize such effect by modifying the vaccine dose. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: July 6, 2020

2020 review

Marek's disease

[Review of Marek’s disease, slide set #26, by I. M. Gimeno, R. L. Witter, & A. Miles]. American Association of Avian Pathologists.

By: I. Gimeno 

Source: NC State University Libraries
Added: September 8, 2022

2020 chapter

Marek’s disease

In D. A. Swayne, D. Suarez, V. Nair, L. R. McDougald, M. Boulianne, C. Logue, … G. Zavala (Eds.), Diseases of Poultry (14th ed., pp. 550–587).

By: V. Nair, I. Gimeno  & J. Dunn

Ed(s): D. Swayne, D. Suarez, V. Nair, L. McDougald, M. Boulianne, C. Logue, S. de Wit, T. Grimes ...

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: NC State University Libraries
Added: October 21, 2020

2019 journal article

Evaluation of factors that influence dose variability of Marek’s disease vaccines

Avian Diseases.

By: B. Lopez de Juan Abad  n, A. Cortes n, M. Correa  n & I. Gimeno n 

author keywords: Marek's disease; vaccines; titers; variability; plaque assay; dose
MeSH headings : Animals; Chick Embryo; Chickens; Dose-Response Relationship, Immunologic; Mardivirus / immunology; Marek Disease / prevention & control; Marek Disease Vaccines / immunology; Poultry Diseases / prevention & control; Vaccination / veterinary
TL;DR: It is shown that dose variability can jeopardize the uniformity of vaccination in a flock and therefore the success of vaccination and the relevance of proper handling of MD vaccines is emphasized. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: November 11, 2019

2019 journal article

Highly virulent Marek's disease virus strains affect T lymphocyte function and viability of splenocytes in commercial meat-type chickens

AVIAN PATHOLOGY, 48(6), 564–572.

By: I. Gimeno n , A. Cortes n, S. Reddy*, B. Abad  n, T. Kaser  n & A. Limsatanun n

author keywords: Marek's disease virus; immunosuppression; virulence; MHC-I; lymphocyte proliferation; spleen
MeSH headings : Animals; Cell Proliferation; Chickens / immunology; Chickens / virology; Female; Herpesvirus 2, Gallid / pathogenicity; Immunosuppression Therapy / veterinary; Marek Disease / virology; Poultry Diseases / virology; Spleen / virology; T-Lymphocytes / virology; Virulence
TL;DR: Results suggest that although cell death and decrease lymphocyte function seem to be related to MDV virulence and certainly will be associated with immunosuppression, they might not fully explain the previously reported MDV-IS. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: September 3, 2019

2019 journal article

Study of Efficacy and Replication of Recombinant Vector Vaccines by Using Turkey Herpesvirus Combined with Other Marek's Disease Vaccines

AVIAN DISEASES, 63(2), 335–341.

By: I. Gimeno n , A. Cortes n, A. Reilley, T. Barbosa, I. Alvarado, R. Koopman, A. Martinez

author keywords: rHVT; vaccines; CVI988; control; Marek's disease
MeSH headings : Animals; Chickens; Female; Herpesvirus 1, Meleagrid / immunology; Herpesvirus 2, Gallid / immunology; Marek Disease / prevention & control; Marek Disease / virology; Marek Disease Vaccines / pharmacology; Poultry Diseases / prevention & control; Poultry Diseases / virology; Vaccination / veterinary
TL;DR: The results show that, when combined with CVI988, HVT and rHVTs confer a similar level of protection against MD (>90%) regardless of whether CVI 988 was used at RD or at DD, however, the combination of rHVT with C VI988 at DD resulted in reduced replication rates of RHVT. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: June 24, 2019

2018 journal article

Differential attenuation of Marek's disease virus-induced tumours and late-Marek's disease virus-induced immunosuppression

JOURNAL OF GENERAL VIROLOGY, 99(7), 927–936.

By: N. Faiz n, A. Cortes n, J. Guy n , S. Reddy* & I. Gimeno n 

author keywords: Marek's disease virus; immunosuppression; virulence; meq; MHC-I
MeSH headings : Animals; Antibodies, Viral / biosynthesis; Carcinogenesis / genetics; Carcinogenesis / immunology; Carcinogenesis / pathology; Chickens; Female; Herpesvirus 1, Gallid / genetics; Herpesvirus 1, Gallid / immunology; Herpesvirus 1, Gallid / pathogenicity; Herpesvirus 2, Gallid / genetics; Herpesvirus 2, Gallid / immunology; Herpesvirus 2, Gallid / pathogenicity; Immunity, Humoral / drug effects; Immunologic Deficiency Syndromes / genetics; Immunologic Deficiency Syndromes / immunology; Immunologic Deficiency Syndromes / veterinary; Immunologic Deficiency Syndromes / virology; Lymphoma / genetics; Lymphoma / immunology; Lymphoma / veterinary; Lymphoma / virology; Marek Disease / genetics; Marek Disease / immunology; Marek Disease / pathology; Marek Disease / virology; MicroRNAs / genetics; MicroRNAs / immunology; RNA, Viral / genetics; RNA, Viral / immunology; Species Specificity; Viral Vaccines / administration & dosage; Virulence
TL;DR: It is suggested that the immunosuppressive ability of MDV might follow a continuous spectrum and only the most virulent MDVs can overcome a certain threshold level and induce clinical MDV-IS in the ILT model. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2018 journal article

Effect of Marek’s disease vaccines on interferon and toll like receptors when administered in ovo

Veterinary Immunology and Immunopathology, 201, 62–66.

By: I. Gimeno* , A. Glaize*  & A. Cortes

author keywords: IFN; TLR; in ovo; Vaccines; Marek's disease; Chickens
MeSH headings : Animals; Chick Embryo; Chickens / immunology; Herpesvirus 2, Gallid; Interferon-gamma / genetics; Interferon-gamma / immunology; Interferons / genetics; Interferons / immunology; Marek Disease / immunology; Marek Disease / prevention & control; Marek Disease Vaccines / administration & dosage; Marek Disease Vaccines / immunology; Specific Pathogen-Free Organisms; Spleen / immunology; Toll-Like Receptor 3 / genetics; Toll-Like Receptor 3 / immunology; Toll-Like Receptors / genetics; Toll-Like Receptors / immunology; Vaccination / veterinary
TL;DR: It is shown that intra-amniotic vaccination at ED18 with HVT but not with CVI988 rendered chickens more immunocompetent at hatch and the role of increased transcription of TLR-3 and IFN-γ in such positive effect warrant further investigations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, ORCID
Added: November 11, 2019

2018 journal article

Use of real-time PCR to rule out Marek's disease in the diagnosis of peripheral neuropathy

AVIAN PATHOLOGY, 47(4), 427–433.

By: S. Gall n, L. Korosi *, A. Cortes n, A. Delvecchio*, F. Prandini*, P. Mitsch, I. Gimeno n 

author keywords: Peripheral neuropathy; Marek's disease; diagnosis; real-time PCR; nerve enlargement
MeSH headings : Animals; Chickens / virology; DNA, Viral / analysis; DNA, Viral / genetics; Diagnosis, Differential; Mardivirus / genetics; Mardivirus / isolation & purification; Marek Disease / diagnosis; Marek Disease / pathology; Marek Disease / virology; Peripheral Nervous System Diseases / diagnosis; Peripheral Nervous System Diseases / pathology; Peripheral Nervous System Diseases / veterinary; Poultry Diseases / diagnosis; Poultry Diseases / pathology; Real-Time Polymerase Chain Reaction / veterinary
TL;DR: A case report shows for the first time how real-time PCR to detect oncogenic MDV is a very valuable tool in the differential diagnosis of PN and MD. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2018 journal article

Virus-Induced Immunosuppression in Chickens

Avian Diseases, 62(3), 272–285.

By: I. Gimeno n  & K. Schat *

author keywords: immunosuppression; chickens; Marek's disease virus; infectious bursal disease virus; chicken infectious anemia virus
MeSH headings : Animals; Birnaviridae Infections / immunology; Birnaviridae Infections / veterinary; Chicken anemia virus / immunology; Chickens; Circoviridae Infections / immunology; Circoviridae Infections / veterinary; Herpesvirus 2, Gallid / immunology; Immunity, Cellular; Immunity, Humoral; Immunosuppression Therapy / veterinary; Infectious bursal disease virus / immunology; Marek Disease / immunology; Poultry Diseases / immunology; Vaccination / veterinary; Viral Vaccines / immunology
TL;DR: This paper reviews the three viral diseases that most commonly induce IS or subclinical IS in chickens: Marek's disease virus, chicken infectious anemia virus (CIAV), and infectious bursal disease virus (IBDV), as well as the interactions among them. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, ORCID
Added: December 5, 2019

2017 report

Dissection of a Marek’s disease outbreak

[Technical bulletin]. Lenexa, KS: CEVA.

By: I. Gimeno 

Source: NC State University Libraries
Added: October 25, 2020

2017 journal article

Evaluation of factors influencing the development of late Marek's disease virus-induced immunosuppression: virus pathotype and host sex

AVIAN PATHOLOGY, 46(4), 376–385.

By: N. Faiz n, A. Cortes n, J. Guy n , O. Fletcher n, T. Cimino & I. Gimeno n 

author keywords: MDV; ILTV; immunosuppression; pathotype; host sex
MeSH headings : Animals; Chickens; Female; Gene Expression Regulation / immunology; Male; Mardivirus / classification; Marek Disease / immunology; Marek Disease / prevention & control; Marek Disease / virology; MicroRNAs / genetics; MicroRNAs / metabolism; Sex Factors; Specific Pathogen-Free Organisms; Viral Vaccines / immunology
TL;DR: The findings suggest that late-MDV-IS is a unique feature of vv+ strains, and the role of two factors (MDV pathotype and host sex) on the development of this feature is investigated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 report

Marek's Disease Virus

(Technical Bulletin No. 0417-AVN-065). Huntsville, AL: Aviagen International Ltd.

By: I. Gimeno 

Source: NC State University Libraries
Added: October 21, 2020

2017 report

Marek’s disease control

[Technical bulletin]. Lenexa, KS: CEVA.

By: I. Gimeno 

Source: NC State University Libraries
Added: October 26, 2020

2017 report

Understanding Marek’s disease

[Technical bulletin]. Lenexa, KS: CEVA.

By: I. Gimeno 

Source: NC State University Libraries
Added: October 26, 2020

2016 journal article

Early infection with Marek's disease virus can jeopardize protection conferred by laryngotracheitis vaccines: a method to study MDV-induced immunosuppression

AVIAN PATHOLOGY, 45(6), 606–615.

By: N. Faiz n, A. Cortes n, J. Guy n , O. Fletcher n, M. West n, E. Montiel, I. Gimeno n 

author keywords: Marek's disease; immunosuppression; laryngotracheitis; model; MDV-induced immunosuppression
MeSH headings : Animals; Chickens / immunology; Chickens / virology; Female; Herpesvirus 2, Gallid / immunology; Immunosuppression Therapy; Marek Disease / immunology; Marek Disease / virology; Models, Immunological; Specific Pathogen-Free Organisms; Tracheitis / prevention & control; Tracheitis / veterinary; Tracheitis / virology; Vaccination / veterinary; Viral Vaccines / immunology
TL;DR: The objective was to document the impact of late-MDV-IS on commercial poultry (meat-type chickens bearing MAb against MDV and that were vaccinated or unvaccinated against MD) and to optimize a model to study late- MDv-IS under laboratory conditions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

Efficacy of Various HVT Vaccines (Conventional and Recombinant) Against Marek's Disease in Broiler Chickens: Effect of Dose and Age of Vaccination

AVIAN DISEASES, 60(3), 662–668.

By: I. Gimeno n , A. Cortes n, N. Faiz n, T. Villalobos, H. Badillo & T. Barbosa

author keywords: HVT; recombinant; vaccination; in ovo; MDV; control
MeSH headings : Age Factors; Animals; Chickens; Dose-Response Relationship, Immunologic; Female; Herpesvirus 1, Meleagrid / immunology; Marek Disease / prevention & control; Marek Disease / virology; Marek Disease Vaccines / administration & dosage; Marek Disease Vaccines / pharmacology; Poultry Diseases / prevention & control; Poultry Diseases / virology; Vaccination / veterinary; Vaccines, Synthetic / administration & dosage; Vaccines, Synthetic / pharmacology
TL;DR: The results show that each HVT product is unique, regardless of being conventional or recombinant, in their ability to protect against MD and might require different PFUs to achieve its maximum efficacy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

Efficacy of various Marek's disease vaccines protocols for prevention of Marek's disease virus-induced immunosuppression

VACCINE, 34(35), 4180–4187.

By: N. Faiz n, A. Cortes n, J. Guy n , J. Fogle n & I. Gimeno n 

author keywords: MDV; Control; ILTV; Immunosuppression; Immune system; Vaccine
MeSH headings : Animals; Chickens; Female; Immune Tolerance; Marek Disease / immunology; Marek Disease / prevention & control; Marek Disease Vaccines / administration & dosage; Marek Disease Vaccines / adverse effects; Neoplasms / virology; Poultry Diseases / prevention & control; Vaccination / methods; Vaccination / veterinary
TL;DR: It is demonstrated that currently used vaccine protocols confer high levels of protection against MDV-induced tumors (protection index=100), but do not protect against late-MDV-IS; thus, commercial poultry flocks could suffer late- MDv-IS even in complete absence of tumors. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 chapter

Marek’s disease.

In S. Williams (Ed.), A laboratory manual for the isolation, identification and characterization of avian pathogens (6th ed.). Jacksonville, FL: American Association of Avian Pathologists.

By: I. Gimeno  & P. Walkenell

Ed(s): S. Williams

Source: NC State University Libraries
Added: October 21, 2020

2015 journal article

Evaluation of Factors Influencing Efficacy of Vaccine Strain CVI988 Against Marek's Disease in Meat-Type Chickens

AVIAN DISEASES, 59(3), 400–409.

By: I. Gimeno n , A. Cortes n, N. Faiz n, T. Barbosa* & T. Villalobos*

author keywords: CVI988; vaccination; in ovo; meat type; MD; control; avian
MeSH headings : Animals; Chickens / classification; Genome, Viral; Lymphoid Tissue; Marek Disease / diagnosis; Marek Disease / prevention & control; Real-Time Polymerase Chain Reaction / veterinary; Viral Load; Viral Vaccines / immunology
TL;DR: The results show that, regardless of the origin of the vaccine, protection against early challenge with 648A was good when vaccines were administered at a high dose, confirming that early diagnosis is a very powerful tool with which to evaluate protection. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

Evaluation of the Protection Efficacy of a Serotype 1 Marek's Disease Virus-Vectored Bivalent Vaccine Against Infectious Laryngotracheitis and Marek's Disease

Avian Diseases, 59(2), 255–262.

By: I. Gimeno n , A. Cortes n, N. Faiz n, B. Hernandez-Ortiz n, J. Guy n , H. Hunt*, R. Silva*

author keywords: Marek's disease; laryngotracheitis; poultry; avian; vaccine; control; herpesvirus
MeSH headings : Animals; Chickens; Female; Herpesviridae Infections / prevention & control; Herpesviridae Infections / veterinary; Herpesvirus 1, Gallid / immunology; Mardivirus / classification; Mardivirus / immunology; Marek Disease / prevention & control; Pilot Projects; Vaccines, DNA; Viral Vaccines / immunology; Virus Replication
TL;DR: Two recombinant vaccines against MD and LT are developed by using BAC&dgr;MEQ as a vector that carries either the LT virus (LTV) gene glycoprotein B (gB; BAC &Dgr; MEQ-gB) or LTV gene glyCoprotein J (gJ; Bac&dGr;MEZ-gJ) by using serotype 1 MDV as vectors. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2015 journal article

In Ovo Vaccination with Turkey Herpesvirus Hastens Maturation of Chicken Embryo Immune Responses in Specific-Pathogen-Free Chickens

AVIAN DISEASES, 59(3), 375–383.

By: I. Gimeno n , N. Faiz n, A. Cortes n, T. Barbosa*, T. Villalobos* & A. Pandiri *

author keywords: HVT; vaccination; in ovo; immune system; immune competence; MDV; avian
MeSH headings : Animals; Antibodies, Viral / blood; Cell Proliferation; Chick Embryo / immunology; Chickens / immunology; Herpesvirus 1, Meleagrid / immunology; Lymphocytes / physiology; Marek Disease / prevention & control; Specific Pathogen-Free Organisms; Spleen / cytology; Vaccination / veterinary; Viral Vaccines / administration & dosage; Viral Vaccines / immunology
TL;DR: Results of this study show that it is possible to hasten maturation of the chicken embryo immune system by administering HVT in ovo and open new avenues to optimize the procedure to improve and strengthen the immunocompetency of commercial chickens at hatch. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

Persistence and Retention of Porcine Reproductive and Respiratory Syndrome Virus in Stable Flies (Diptera: Muscidae)

JOURNAL OF MEDICAL ENTOMOLOGY, 52(5), 1117–1123.

By: K. Rochon*, R. Baker*, G. Almond n , I. Gimeno n , A. De Leon* & D. Watson n

author keywords: Stomoxys calcitrans; intrathoracic inoculation; midgut barrier; virus persistence
MeSH headings : Animals; Insect Vectors / virology; Muscidae / virology; Porcine respiratory and reproductive syndrome virus / physiology; RNA, Viral / analysis; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Virus Replication
TL;DR: Stable flies acquired PRRSV from the bloodmeal and the amount of virus in the flies declined with time, indicating virus did not replicate in fly digestive tissues, and detectable virus quantities in the intrathoracically inoculated stable flies followed an exponential decay curve. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

Detection and Differentiation of CVI988 (Rispens Vaccine) from Other Serotype 1 Marek's Disease Viruses

AVIAN DISEASES, 58(2), 232–243.

By: I. Gimeno n , J. Dunn *, A. Cortes n, A. El-Gohary* & R. Silva*

author keywords: real time PCR; poultry; avian; diagnosis; vaccine; MDV; Rispens; CVI988
MeSH headings : Animals; Chick Embryo; Chickens; Herpesvirus 2, Gallid / genetics; Herpesvirus 2, Gallid / immunology; Herpesvirus 3, Gallid / genetics; Herpesvirus 3, Gallid / immunology; Marek Disease / immunology; Marek Disease / prevention & control; Marek Disease Vaccines / genetics; Marek Disease Vaccines / immunology; Polymorphism, Single Nucleotide; Poultry Diseases / immunology; Poultry Diseases / prevention & control; Real-Time Polymerase Chain Reaction / methods; Real-Time Polymerase Chain Reaction / veterinary; Vaccines, Attenuated / genetics; Vaccines, Attenuated / immunology
TL;DR: Validation of MAMA primers in in vivo samples demonstrated that oncogenic primers can be used for both early diagnosis of MD in feather pulp samples collected at 3 wk of age and confirmation of MD diagnosis in tumors. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 chapter

Marek’s Disease and Differential Diagnosis with Other Tumor Viral Diseases of Poultry

In N. K. Van Alfen (Ed.), Encyclopedia of Agriculture and Food Systems (pp. 156–171). London, UK: Academic Press/Elsevier.

By: I. Gimeno 

Ed(s): N. Van Alfen

Source: NC State University Libraries
Added: October 21, 2020

2013 article

Current Status of Marek's Disease in the United States and Worldwide Based on a Questionnaire Survey

Dunn, J. R., & Gimeno, I. M. (2013, June). AVIAN DISEASES, Vol. 57, pp. 483–490.

By: J. Dunn * & I. Gimeno n 

author keywords: Marek's disease; MDV; poultry; epidemiology; incidence; questionnaire
MeSH headings : Animals; Chickens; Female; Incidence; Male; Marek Disease / epidemiology; Marek Disease / prevention & control; Marek Disease / virology; Poultry Diseases / epidemiology; Poultry Diseases / prevention & control; Poultry Diseases / virology; Prevalence; Surveys and Questionnaires; United States / epidemiology
TL;DR: A questionnaire was widely distributed in 2011 to estimate the global prevalence of Marek's disease (MD) and gain a better understanding of current control strategies and future concerns and indicated increasing MD incidence was likely due to higher virulent strains, while the presence of other immunosuppressive diseases was a more common explanation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2013 chapter

Virus-induced immunosuppression: Marek’s disease virus infection and associated syndromes

In I. M. Gimeno (Ed.), Immunosuppressive diseases of poultry (pp. 124–152). Zaragoza, Spain: Servet, Grupo Asís Biomedia, S.L.

By: I. Gimeno  & A. Pandiri

Ed(s): I. Gimeno 

Source: NC State University Libraries
Added: October 21, 2020

2012 journal article

Cost effective and time efficient measurement of CD4, CD8, major histocompatibility complex Class II, and macrophage antigen expression in the lungs of chickens

Veterinary Immunology and Immunopathology, 146(3-4), 225–236.

By: O. Fletcher  n, X. Tan  n, L. Cortes n & I. Gimeno n 

author keywords: imageJ; Chicken; Marek's disease; Lung; CD4; CD8; Major histocompatibility complex Class II; Macrophages
MeSH headings : Animals; Antigens, Viral / immunology; CD4-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / immunology; Chickens; Herpesvirus 2, Gallid / genetics; Herpesvirus 2, Gallid / immunology; Histocompatibility Antigens Class II / immunology; Image Processing, Computer-Assisted / methods; Image Processing, Computer-Assisted / standards; Immunohistochemistry / veterinary; Lung Diseases / diagnosis; Lung Diseases / immunology; Lung Diseases / veterinary; Macrophages, Alveolar / chemistry; Macrophages, Alveolar / immunology; Marek Disease / diagnosis; Marek Disease / immunology; Marek Disease / virology; Poultry Diseases / diagnosis; Poultry Diseases / immunology; Poultry Diseases / virology; RNA, Viral / chemistry; RNA, Viral / genetics; Random Allocation; Real-Time Polymerase Chain Reaction / veterinary; Retrospective Studies; Specific Pathogen-Free Organisms
TL;DR: Using imageJ as described eliminates the need for subjective and less reproducible methods for measuring expression of these antigens, and is faster and more reproducible than manual counting in cases (CD4 and CD8) where the number of positive cells is low enough for manual counts. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, ORCID
Added: July 21, 2019

2012 journal article

Dynamic equilibrium of Marek's disease genomes during in vitro serial passage

VIRUS GENES, 45(3), 526–536.

By: S. Spatz *, J. Volkening, I. Gimeno n , M. Heidari * & R. Witter*

author keywords: Marek's disease; Marek's disease virus; Sequencing; Polymorphisms; Serial passage; Gallid herpesvirus 2; Pyrosequencing; Virulence
MeSH headings : Animals; Chick Embryo; DNA, Viral / genetics; Fibroblasts / virology; Genome, Viral; Genotype; Herpesvirus 2, Gallid / genetics; Herpesvirus 2, Gallid / physiology; High-Throughput Nucleotide Sequencing / methods; Marek Disease / virology; Mutagenesis, Insertional; Nuclear Proteins / genetics; Nucleic Acid Conformation; Oncogene Proteins, Viral / genetics; Open Reading Frames; Promoter Regions, Genetic; Sequence Analysis, DNA; Sequence Deletion; Serial Passage; Trans-Activators / genetics; Virus Cultivation / methods; Virus Replication
TL;DR: Serial passage of GaHV-2 results in the generation of a collection of genomes with limited sequence heterogeneity, which indicates that serial passage of the causative agent of Marek’s disease results inThe frequency of mutations fluctuated greatly during serial passage and few genetic changes were absolute. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 journal article

Optimization of the Protocols for Double Vaccination Against Marek's Disease by Using Commercially Available Vaccines: Evaluation of Protection, Vaccine Replication, and Activation of T Cells

AVIAN DISEASES, 56(2), 295–305.

By: I. Gimeno* , A. Cortes*, R. Witter* & A. Pandiri

author keywords: revaccination; Marek's disease; control; vaccine
MeSH headings : Animals; Chick Embryo; Chickens; DNA, Viral / analysis; Dose-Response Relationship, Immunologic; Immunization, Secondary / veterinary; Mardivirus / physiology; Marek Disease / prevention & control; Marek Disease Vaccines / administration & dosage; Marek Disease Vaccines / immunology; Real-Time Polymerase Chain Reaction / veterinary; Specific Pathogen-Free Organisms; T-Lymphocytes / immunology; Time Factors; Vaccination / veterinary
TL;DR: It is demonstrated that it is possible to improve efficacy of the currently available vaccines by using them in revaccination programs and to determine whether two features associated with Marek's disease vaccine-induced protection (activation of T cells and replication of vaccine virus) are involved in theRevaccination protocols. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 journal article

Reversion to Subgroup J Avian Leukosis Virus Viremia in Seroconverted Adult Meat-Type Chickens Exposed to Chronic Stress by Adrenocorticotrophin Treatment

AVIAN DISEASES, 56(3), 578–582.

By: A. Pandiri *, I. Gimeno n , J. Mays*, W. Reed* & A. Fadly*

author keywords: stress; avian leukosis virus subgroup j; viremia; shedding; adrenocorticotrophin treatment; meat-type chickens; reversion to viremia
MeSH headings : Adrenocorticotropic Hormone / administration & dosage; Adrenocorticotropic Hormone / toxicity; Animals; Antibodies, Viral; Avian Leukosis / immunology; Avian Leukosis / virology; Avian Leukosis Virus / classification; Avian Leukosis Virus / genetics; Chickens; Male; Poultry Diseases / virology; Stress, Physiological / drug effects; Stress, Physiological / immunology; Viremia
TL;DR: It is suggested that treatment of chickens with ACTH can cause reversion of viremia and cloacal shedding in ALV J–seroconverted adult male chickens that had been exposed to the virus at hatch, but not in chickens that were contact-exposed at 32 wk of age. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 journal article

Standardization of a model to study revaccination against Marek's disease under laboratory conditions

Avian Pathology, 41(1), 59–68.

By: I. Gimeno n , R. Witter, A. Cortes n, S. Reddy* & A. Pandiri  n

MeSH headings : Animals; Chickens; DNA Primers / genetics; Female; Immunization, Secondary / methods; Immunization, Secondary / veterinary; Lymphoid Tissue / pathology; Male; Marek Disease / prevention & control; Marek Disease Vaccines; Models, Animal; Real-Time Polymerase Chain Reaction / veterinary
TL;DR: The results show that revaccination protocols might aid in solving major drawbacks associated with various highly protective experimental MD vaccines; that is, lymphoid organ atrophy and residual virulence. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, ORCID
Added: July 21, 2019

2011 journal article

Chronological study of cytokine transcription in the spleen and lung of chickens after vaccination with serotype 1 Marek's disease vaccines

VACCINE, 29(8), 1583–1594.

By: I. Gimeno n  & A. Cortes n

author keywords: Marek's disease; Vaccine; Cytokine
MeSH headings : Animals; Chickens / immunology; Cytokines / biosynthesis; Herpesvirus 2, Gallid / immunology; Lung / immunology; Marek Disease / immunology; Marek Disease / prevention & control; Marek Disease Vaccines / immunology; Nitric Oxide Synthase Type II / biosynthesis; Poultry Diseases / immunology; Poultry Diseases / prevention & control; Specific Pathogen-Free Organisms; Spleen / immunology; Time Factors; Vaccination / veterinary; Viral Load
TL;DR: It is demonstrated that MD vaccines administered subcutaneously elicit a pulmonary immune response and differences in the cytokine gene expression between HP and LP vaccinated chickens are identified. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2011 journal article

Comparison of Blood and Feather Pulp Samples for the Diagnosis of Marek's Disease and for Monitoring Marek's Disease Vaccination by Real Time-PCR

AVIAN DISEASES, 55(2), 302–310.

By: A. Cortes*, E. Montiel, S. Lemiere & I. Gimeno* 

author keywords: Marek's disease; real time-PCR; plaque assay; vaccines; diagnosis
MeSH headings : Animals; Chickens; DNA, Viral / isolation & purification; Feathers / virology; Mardivirus / genetics; Marek Disease / blood; Marek Disease / diagnosis; Marek Disease / prevention & control; Marek Disease Vaccines / immunology; Polymerase Chain Reaction / methods; Polymerase Chain Reaction / veterinary; Vaccination; Viral Plaque Assay
TL;DR: Comparison of blood and feather pulp (FP) samples for the diagnosis of Marek's disease (MD) and for monitoring MareK's diseases vaccination in chickens (serotypes 2 and 3 vaccines) by real time-PCR was evaluated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2011 journal article

Effect of Diluting Marek's Disease Vaccines on the Outcomes of Marek's Disease Virus Infection When Challenged with Highly Virulent Marek's Disease Viruses

AVIAN DISEASES, 55(2), 263–272.

By: I. Gimeno* , A. Cortes*, E. Montiel, S. Lemiere & A. Pandiri

author keywords: Marek's disease; control; vaccines; dilution
MeSH headings : Animals; Body Weight; DNA, Viral; Dose-Response Relationship, Immunologic; Female; Male; Mardivirus / pathogenicity; Marek Disease / prevention & control; Marek Disease Vaccines / administration & dosage; Marek Disease Vaccines / immunology; Virulence
TL;DR: It was shown that dilution of MD vaccines can lead to reduced MD protection, reduced relative body weights, reduced vaccine DNA during the first 3 wk, and increased MDV DNA load. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2011 journal article

Replication ability of three highly protective Marek's disease vaccines: implications in lymphoid organ atrophy and protection

AVIAN PATHOLOGY, 40(6), 573–579.

By: I. Gimeno n , R. Witter, A. Cortes n & W. Reed

MeSH headings : Analysis of Variance; Animals; Atrophy; Chickens; DNA Primers / genetics; Herpesvirus 2, Gallid / immunology; Herpesvirus 2, Gallid / pathogenicity; Immunohistochemistry; Lymphoid Tissue / pathology; Lymphoid Tissue / virology; Marek Disease / prevention & control; Marek Disease / virology; Marek Disease Vaccines / immunology; Real-Time Polymerase Chain Reaction; Vaccines, Attenuated / immunology; Virus Replication / physiology
TL;DR: The study of the target cells for the early infection in cell suspensions of blood and spleen showed that both non-adherent cell populations (enriched in lymphoid cells) and adherent cells (en enriched in monocytes/macrophages) supported MD virus infection. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2011 journal article

Replication of recombinant herpesvirus of turkey expressing genes of infectious laryngotracheitis virus in specific pathogen free and broiler chickens following in ovo and subcutaneous vaccination

AVIAN PATHOLOGY, 40(4), 395–403.

By: I. Gimeno n , A. Cortes n, J. Guy n , E. Turpin* & C. Williams *

MeSH headings : Animals; Antibodies, Viral / blood; Chick Embryo; Chickens / immunology; Chickens / virology; Female; Herpesviridae Infections / immunology; Herpesviridae Infections / prevention & control; Herpesviridae Infections / veterinary; Herpesvirus 1, Gallid / genetics; Herpesvirus 1, Gallid / immunology; Herpesvirus 1, Gallid / physiology; Injections, Subcutaneous / veterinary; Organisms, Genetically Modified; Poultry Diseases / immunology; Poultry Diseases / prevention & control; Poultry Diseases / virology; Specific Pathogen-Free Organisms; Turkeys / virology; Vaccination / methods; Vaccination / veterinary; Vaccines, Synthetic / immunology; Viral Load; Viral Vaccines / administration & dosage; Viral Vaccines / immunology; Virus Replication / immunology
TL;DR: In vivo replication of rHVT-LT vaccine was slower than HVT vaccine, however, in vivo both rH VT-LT and HVT vaccines replicated at similar levels. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2010 journal article

Evaluation of factors influencing replication of serotype 1 Marek's disease vaccines in the chicken lung

AVIAN PATHOLOGY, 39(2), 71–79.

By: I. Gimeno n  & A. Cortes n

MeSH headings : Aging; Animals; Chickens; DNA, Viral / genetics; Dose-Response Relationship, Immunologic; Genes, Viral; Injections, Subcutaneous; Lung / immunology; Lung / virology; Mardivirus / genetics; Mardivirus / physiology; Marek Disease / immunology; Marek Disease / prevention & control; Marek Disease Vaccines / administration & dosage; Marek Disease Vaccines / immunology; Viral Load; Virus Replication
TL;DR: It was shown that HP vaccines tend to replicate better than LP vaccines in the lung; and vaccine replication in the lungs within the first 10 days of age was affected by the age/route of inoculation but not by the dose of vaccine administered. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2010 book

Tumor diagnosis manual: The differential diagnosis of lymphoid and myeloid tumors in the chicken

(First Edition). Jacksonville, Florida: American Association of Avian Pathologists.

By: R. Witter, I. Gimeno , A. Pandiri & A. Fadly

Source: NC State University Libraries
Added: November 4, 2019

2009 chapter

Enfermedad de Marek

In A. J. P. Ferreira & L. Revolledo (Eds.), Principios Basicos de Patologia Aviar (pp. 193–228). Guanabara Koogan, Brazil.

By: I. Gimeno 

Ed(s): A. Ferreira & L. Revolledo

Source: NC State University Libraries
Added: November 4, 2019

2009 journal article

Subgroup J Avian Leukosis Virus-Induced Histiocytic Sarcomatosis Occurs Only in Persistently Viremic but Not Immunotolerized Meat-type Chickens

VETERINARY PATHOLOGY, 46(2), 282–287.

By: A. Pandiri  n, I. Gimeno n , W. Reed*, S. Fitzgerald* & A. Fadly

author keywords: Chickens; histiocytic sarcoma; subgroup J avian leukosis virus; viral persistence
MeSH headings : Animals; Avian Leukosis Virus / classification; Chickens; Histiocytic Sarcoma / immunology; Histiocytic Sarcoma / pathology; Histiocytic Sarcoma / veterinary; Histiocytic Sarcoma / virology; Liver / pathology; Meat; Poultry Diseases / pathology; Poultry Diseases / virology; Spleen / pathology; Viremia
TL;DR: The above observations suggest that the mechanisms of oncogenesis of HS might be different from that of other ALV J-induced tumors, and the roles of subgroup J avian leukosis virus and ADOL line 0 chickens was evaluated using retrospective analysis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2009 journal article

Validation of Marek's Disease Diagnosis and Monitoring of Marek's Disease Vaccines from Samples Collected in FTA (R) Cards

AVIAN DISEASES, 53(4), 510–516.

By: A. Cortes n, E. Montiel & I. Gimeno n 

author keywords: Marek's disease; real-time PCR; FTA (R) cards; vaccines; diagnosis
MeSH headings : Animals; Chickens; DNA, Viral / analysis; Marek Disease / diagnosis; Marek Disease / prevention & control; Polymerase Chain Reaction / veterinary; Reproducibility of Results; Sequence Analysis, DNA / veterinary; Specimen Handling / methods; Specimen Handling / veterinary; Viral Load; Viral Vaccines / immunology
TL;DR: FTA cards are an excellent media to collect, transport, and archive samples for MD diagnosis and to monitor MD vaccines and are widely available, inexpensive, and adequate for the shipment of samples nationally and internationally. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2008 journal article

Deletion of the Marek’s disease virus UL41 gene (vhs) has no measurable effect on latency or pathogenesis

Virus Genes, 36(3), 499–507.

By: I. Gimeno*  & R. Silva*

author keywords: herpesvirus; poultry; avian; mutant; pathogenesis; MDV
MeSH headings : Animals; Cell Transformation, Neoplastic; Chick Embryo; Chickens; Female; Gene Deletion; Herpesvirus 2, Gallid / genetics; Herpesvirus 2, Gallid / growth & development; Herpesvirus 2, Gallid / pathogenicity; Herpesvirus 2, Gallid / physiology; Male; Marek Disease / pathology; Marek Disease / virology; Ribonucleases; Viral Proteins / genetics; Viral Proteins / metabolism; Virulence; Virus Activation; Virus Latency; Virus Replication
TL;DR: A transient co-transfection assay was utilized and demonstrated that the MDV UL41 protein was as active in degrading RNA as the vhs protein of herpes simplex virus type 1. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: July 21, 2019

2008 journal article

Distribution of viral antigen gp85 and provirus in various tissues from commercial meat-type and experimental White Leghorn Line 0 chickens with different subgroup J avian leukosis virus infection profiles

Avian Pathology, 37(1), 7–13.

By: A. Pandiri *, I. Gimeno* , W. Reed*, L. Lee, R. Silva & A. Fadly

MeSH headings : Animals; Antigens, Viral / isolation & purification; Antigens, Viral / metabolism; Avian Leukosis / metabolism; Avian Leukosis / virology; Avian Leukosis Virus / classification; Chickens / genetics; DNA, Viral / isolation & purification; Meat; Proviruses / isolation & purification; Retrospective Studies
TL;DR: The results suggest that PCR using primer pair H5/H7 is more sensitive than immunohistochemistry in identifying ALV J in chickens that have been exposed to virus, but are not actively viraemic. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: November 4, 2019

2008 journal article

Identification of Marek's disease virus genes mutated during serial passage-induced attenuation

Vaccine.

By: S. Spatz, I. Gimeno  & M. Heidari

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Load of Challenge Marek's Disease Virus DNA in Blood as a Criterion for Early Diagnosis of Marek's Disease Tumors

AVIAN DISEASES, 52(2), 203–208.

By: I. Gimeno* , A. Cortes* & R. Silva*

author keywords: Marek's disease; vaccination; control; protection; monitoring
MeSH headings : Animals; Base Sequence; Chickens; DNA Primers / genetics; DNA, Viral / blood; DNA, Viral / genetics; Disease Outbreaks / prevention & control; Disease Outbreaks / veterinary; Female; Herpesvirus 1, Meleagrid / genetics; Herpesvirus 1, Meleagrid / isolation & purification; Herpesvirus 2, Gallid / genetics; Herpesvirus 2, Gallid / isolation & purification; Male; Marek Disease / diagnosis; Marek Disease / epidemiology; Marek Disease / prevention & control; Marek Disease / virology; Marek Disease Vaccines / genetics; Marek Disease Vaccines / pharmacology; Models, Biological; Viral Load / veterinary
TL;DR: It was shown that load of challenge MDV DNA but not load of HVT DNA in blood can be used as criterion for early diagnosis of Marek's disease. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2008 journal article

Marek's Disease Virus Infection in the Eye: Chronological Study of the Lesions, Virus Replication, and Vaccine-Induced Protection

AVIAN DISEASES, 52(4), 572–580.

By: A. Pandiri, A. Cortes*, L. Lee* & I. Gimeno* 

author keywords: Marek's diseases; eye; retina; pathogenesis
MeSH headings : Animals; Chickens; Choroid / pathology; Eye Infections, Viral / pathology; Eye Infections, Viral / prevention & control; Eye Infections, Viral / veterinary; Eye Infections, Viral / virology; Female; Immunohistochemistry; Male; Mardivirus / immunology; Mardivirus / physiology; Marek Disease / immunology; Marek Disease / pathology; Marek Disease / prevention & control; Marek Disease Vaccines / immunology; Retina / pathology; Time Factors; Virus Replication / physiology
TL;DR: The effect of vaccination on the development of ocular lesions was studied chronologically after inoculating 1-day-old chickens with a very virulent MDV strain, Md5, to enhance the understanding of the nature and pattern of MDV infection in the eye. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2008 review

Marek's disease vaccines: A solution for today but a worry for tomorrow?

[Review of ]. VACCINE, 26, C31–C41.

By: I. Gimeno n 

author keywords: Marek's disease; virulence; vaccines
MeSH headings : Animals; Chickens; Evolution, Molecular; Herpesvirus 2, Gallid / genetics; Herpesvirus 2, Gallid / pathogenicity; Marek Disease / epidemiology; Marek Disease / immunology; Marek Disease / prevention & control; Marek Disease / virology; Marek Disease Vaccines / administration & dosage; Poultry Diseases / epidemiology; Poultry Diseases / immunology; Poultry Diseases / prevention & control; Poultry Diseases / virology; Vaccination; Virulence
TL;DR: Sterilizing immunity could be a solution to stop the evolution of the virus but it has been proven to be extremely difficult, if at all possible, to obtain with MDV or with other herpesviruses. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2007 journal article

Oncogenic Marek’s disease viruses lacking the 132 base pair repeats can still be attenuated by serial in vitro cell culture passages

Virus Genes, 34(1), 87–90.

By: R. Silva* & I. Gimeno* 

author keywords: herpesvirus; lymphoma; cosmid; deletion mutant; chicken
MeSH headings : Animals; Cells, Cultured; Chickens; Ducks; Embryo, Nonmammalian; Gene Deletion; Genes, Viral; Herpesvirus 2, Gallid / genetics; Herpesvirus 2, Gallid / pathogenicity; Herpesvirus 3, Gallid / genetics; Herpesvirus 3, Gallid / pathogenicity; Marek Disease / virology; Serial Passage; Viral Plaque Assay; Virus Cultivation; Virus Replication
Sources: Crossref, ORCID
Added: July 21, 2019

2006 journal article

Susceptibility of Adult Chickens, With and Without Prior Vaccination, to Challenge with Marek's Disease Virus

Avian Diseases, 50(3), 354–365.

By: R. Witter* & I. Gimeno* 

author keywords: chicken; virus; Marek's disease; vaccine failure; age; adult
MeSH headings : Aging; Animals; Chickens; Disease Susceptibility; Female; Male; Mardivirus / genetics; Mardivirus / immunology; Marek Disease / immunology; Marek Disease / prevention & control; Marek Disease / virology; Marek Disease Vaccines / administration & dosage; Marek Disease Vaccines / immunology; Specific Pathogen-Free Organisms; Vaccination
TL;DR: The low susceptibility of previously vaccinated and exposed groups to challenge at ≥18 wk of age suggests that late outbreaks of Marek's disease in commercial flocks are not likely a result of recent challenge alone and that additional factors could be involved. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: July 21, 2019

2005 journal article

Characterization of a very Virulent Marek’s Disease Virus Mutant Expressing the pp38 Protein from the Serotype 1 Vaccine Strain CVI988/Rispens

Virus Genes, 31(1), 73–80.

By: L. Lee*, X. Cui*, Z. Cui, I. Gimeno* , B. Lupiani* & S. Reddy*

author keywords: rMd5; CVI988/Rispens; Marek's disease virus; MDV mutant; pp38 protein
MeSH headings : Amino Acid Sequence; Animals; Antibodies, Viral / blood; Antigens, Viral / chemistry; Antigens, Viral / genetics; Antigens, Viral / immunology; Chickens; Female; Gene Expression; Herpesvirus 2, Gallid / chemistry; Herpesvirus 2, Gallid / genetics; Herpesvirus 2, Gallid / immunology; Herpesvirus 2, Gallid / pathogenicity; Male; Marek Disease / immunology; Marek Disease / prevention & control; Marek Disease / virology; Molecular Sequence Data; Mutation; Phosphoproteins / chemistry; Phosphoproteins / genetics; Phosphoproteins / immunology; Poultry Diseases / immunology; Poultry Diseases / prevention & control; Poultry Diseases / virology; Sequence Alignment; Viral Vaccines / chemistry; Viral Vaccines / genetics; Viral Vaccines / immunology; Virulence
TL;DR: A mutant rMd5 virus in which the wild type pp38 gene has been substituted with that of CVI988/Rispens was generated and the replication properties of rMD5/pp38CVI, both in vitro and in vivo, and tumor induction were examined. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, ORCID
Added: July 21, 2019

2005 journal article

Classification of Marek's disease viruses according to pathotype: philosophy and methodology

Avian Pathology, 34(2), 75–90.

By: R. Witter*, B. Calnek*, C. Buscaglia*, I. Gimeno*  & K. Schat *

MeSH headings : Animals; Chickens / genetics; Chickens / virology; Genetic Predisposition to Disease; Mardivirus / classification; Mardivirus / pathogenicity; Marek Disease / virology; Marek Disease Vaccines; Virulence
TL;DR: Based on data from several trials, a modification of the ADOL method that utilizes fewer chickens and can be conducted with commercial specific pathogen free strains is proposed, and is expected to provide results generally comparable with the original method. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, ORCID
Added: July 21, 2019

2005 report

Marek’s disease

(Slide Study Set No. 26). Jacksonville, FL: American Association of Avian Pathologists.

By: I. Gimeno , R. Witter & A. Miles

Source: NC State University Libraries
Added: October 21, 2020

2005 journal article

Novel criteria for the diagnosis of Marek's disease virus-induced lymphomas

Avian Pathology, 34(4), 332–340.

By: I. Gimeno* , R. Witter*, A. Fadly* & R. Silva*

MeSH headings : Animals; Antigens, Neoplasm / metabolism; Antigens, Surface / metabolism; Antigens, Viral / metabolism; Avian Leukosis Virus / isolation & purification; Avian Proteins / metabolism; Biomarkers; Chickens / virology; DNA Methylation; DNA, Viral / analysis; Gene Expression; Genes, Viral; Ki-1 Antigen / metabolism; Lymphoma / diagnosis; Lymphoma / veterinary; Lymphoma / virology; Mardivirus / isolation & purification; Marek Disease / diagnosis; Oncogene Proteins, Viral; Polymerase Chain Reaction; Reticuloendotheliosis Viruses, Avian / isolation & purification; Tumor Suppressor Protein p53 / metabolism; Viral Load
TL;DR: Several novel criteria have been tested to assist in the differential diagnosis of tumours induced by Marek's disease virus (MDV) from those induced by avian leukosis virus (ALV) and reticuloendotheliosis virus (REV). (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, ORCID
Added: July 21, 2019

2005 journal article

The pp38 Gene of Marek's Disease Virus (MDV) Is Necessary for Cytolytic Infection of B Cells and Maintenance of the Transformed State but Not for Cytolytic Infection of the Feather Follicle Epithelium and Horizontal Spread of MDV

Journal of Virology, 79(7), 4545–4549.

By: I. Gimeno* , R. Witter*, H. Hunt*, S. Reddy*, L. Lee* & R. Silva*

MeSH headings : Animals; Antigens, Viral / genetics; Antigens, Viral / physiology; B-Lymphocytes / virology; Cell Transformation, Viral / physiology; Chickens; Epithelial Cells / virology; Gene Deletion; Genes, Viral; Herpesvirus 2, Gallid / genetics; Herpesvirus 2, Gallid / physiology; Phosphoproteins / genetics; Phosphoproteins / physiology
TL;DR: This work shows that the pp38 gene is necessary to establish cytolytic infection in B cells but not in feather follicle epithelium, to produce an adequate level of latently infected T cells, and to maintain the transformed status in vivo. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: July 21, 2019

2004 journal article

Biocharacteristics shared by highly protective vaccines against Marek's disease

Avian Pathology, 33(1), 57–66.

By: I. M. Gimeno, R. Witter, H. Hunt, S. Reddy* & W. Reed*

MeSH headings : Animals; Chickens; DNA, Viral / analysis; Female; Herpesvirus 2, Gallid / genetics; Herpesvirus 2, Gallid / immunology; Herpesvirus 2, Gallid / pathogenicity; Lymphocyte Activation; Male; Marek Disease / prevention & control; Marek Disease Vaccines / immunology; Marek Disease Vaccines / standards; Poultry Diseases / immunology; Poultry Diseases / prevention & control; Serotyping / veterinary; Vaccines, Attenuated / immunology; Vaccines, Attenuated / standards; Virulence; Virus Cultivation; Virus Replication
TL;DR: Results show that in vivo replication and early stimulation of the T-cell lineage are two characteristics shared by HP vaccines, and no single set of characteristics could be used to identify the most protective Marek's disease vaccines, implying, perhaps, that multiple mechanisms may be involved. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, ORCID
Added: July 28, 2019

2004 chapter

Future strategies for controlling Marek's disease

In Marek's Disease (pp. 186-x).

By: I. Gimeno* 

TL;DR: This chapter discusses future strategies that can be implemented to control Marek's disease (MD), and improves current methods of MD control requires the commitment of research institutions, vaccine manufacturers, and breeding companies. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: July 28, 2019

2004 journal article

Marek's disease virus-encoded Meq gene is involved in transformation of lymphocytes but is dispensable for replication

Proceedings of the National Academy of Sciences, 101(32), 11815–11820.

By: B. Lupiani*, L. Lee*, X. Cui, I. Gimeno* , A. Anderson *, R. Morgan*, R. Silva*, R. Witter* ...

MeSH headings : Animals; Cell Transformation, Viral; Chickens; Gene Deletion; Genes, Viral / physiology; Herpesvirus 2, Gallid / chemistry; Herpesvirus 2, Gallid / genetics; Herpesvirus 2, Gallid / physiology; Lymphocyte Activation; Marek Disease / etiology; Marek Disease / virology; Mutagenesis, Site-Directed; Oncogene Proteins, Viral / genetics; Oncogene Proteins, Viral / physiology; Virus Replication
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, ORCID
Added: July 28, 2019

2002 journal article

Neuropathotyping: A New System to Classify Marek's Disease Virus

Avian Diseases, 46(4), 909–918.

By: I. Gimeno* , R. Witter* & U. Neumann

author keywords: Marek's disease virus; pathotype; virulence; neuropathotype
TL;DR: It is established that MDV strains within the very virulent pathotype may be subdivided into neuropathotypes B and C, thus establishing a previously unrecognized pathotypic classification, which illustrates how neuropathotyping may extend important information not identified by conventional pathotyping. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, ORCID
Added: November 4, 2019

2002 journal article

Outbreak of Avian Tuberculosis in 48-Week-Old Commercial Layer Hen Flock

Avian Diseases, 46(4), 1055–1061.

By: M. González *, A. Rodriguez-Bertos *, I. Gimeno* , J. Flores* & M. Pizarro*

author keywords: mycobacteriosis; Mycobacterium avium; tuberculosis; poultry; hen
TL;DR: The lesions observed in the various organs of all the affected birds consisted of granulomas containing acid/alcohol-fast bacilli, and the presence of Mycobacterium avium was confirmed through polymerase chain reaction techniques. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, ORCID
Added: November 17, 2019

2002 journal article

Rescue of a pathogenic Marek's disease virus with overlapping cosmid DNAs: Use of a pp38 mutant to validate the technology for the study of gene function

Proceedings of the National Academy of Sciences, 99(10), 7054–7059.

By: S. Reddy*, B. Lupiani*, I. Gimeno* , R. Silva*, L. Lee* & R. Witter*

MeSH headings : Animals; Antigens, Viral / genetics; Chickens; Cosmids; DNA, Viral; Genes, Overlapping; Genes, Viral; Mardivirus / genetics; Mardivirus / pathogenicity; Marek Disease / pathology; Marek Disease / virology; Phosphoproteins / genetics
TL;DR: Development of overlapping cosmid DNA clones from a very virulent oncogenic strain of Marek's disease virus resulted in the generation of a recombinant MDV (rMd5) with biological properties similar to the parental strain, to demonstrate the applicability of this technology for elucidation of gene function of MDV. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: July 28, 2019

2001 journal article

Differential attenuation of the induction by Marek's disease virus of transient paralysis and persistent neurological disease: A model for pathogenesis studies

Avian Pathology, 30(4), 397–409.

By: I. Gimeno* , R. Witter, H. Hunt, S. Reddy & U. Neumann

TL;DR: It is suggested that transient paralysis and persistent neurological disease are unrelated and differently regulated, and the use of viruses at different passage levels with varying degrees of attenuation is presented as a useful tool for studying pathogenesis of MDV infection. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, ORCID
Added: July 28, 2019

2001 journal article

Marek's Disease Virus Down-Regulates Surface Expression of MHC (B Complex) Class I (BF) Glycoproteins during Active but not Latent Infection of Chicken Cells

Virology, 282(1), 198–205.

By: H. Hunt*, B. Lupiani*, M. Miller *, I. Gimeno* , L. Lee* & M. Parcells

MeSH headings : Animals; Blotting, Western; Cell Line; Cell Membrane / metabolism; Chickens; Down-Regulation; Flow Cytometry; Herpesvirus 2, Gallid / genetics; Herpesvirus 2, Gallid / pathogenicity; Histocompatibility Antigens Class I / metabolism
TL;DR: BF down-regulation begins in the immediate early phase and is complete by the early phase of viral gene expression, indicating that the likely mechanism is a block in BF transport and not the result of transcriptional or translational regulation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, ORCID
Added: July 28, 2019

2001 journal article

Marek's Disease Virus Infection in the Brain: Virus Replication, Cellular Infiltration, and Major Histocompatibility Complex Antigen Expression

Veterinary Pathology, 38(5), 491–503.

By: I. Gimeno* , R. Witter, H. Hunt, L. Lee, S. Reddy & U. Neumann

author keywords: central nervous system; chickens; immunohistochemistry; lesions; major histocompatibility complex; Marek's disease virus; pathogenesis; polymerase chain reaction
MeSH headings : Animals; Antigens, Viral / analysis; Antigens, Viral / immunology; Brain / pathology; Brain / virology; CD4 Lymphocyte Count / veterinary; Chickens; DNA, Viral / analysis; Female; Herpesvirus 2, Gallid / immunology; Herpesvirus 2, Gallid / isolation & purification; Herpesvirus 2, Gallid / physiology; Histocompatibility Antigens Class I / immunology; Histocompatibility Antigens Class II / immunology; Immunohistochemistry / veterinary; Male; Marek Disease / immunology; Marek Disease / pathology; Marek Disease / virology; Polymerase Chain Reaction / veterinary; Viremia / veterinary; Viremia / virology; Virus Replication
TL;DR: The results enhance the understanding of the nature and pattern of MDV infection in the brain and help to explain the neurovirulence associated with highly virulent MDV. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, ORCID
Added: November 17, 2019

2000 journal article

Development of a Quantitative-Competitive Polymerase Chain Reaction Assay for Serotype 1 Marek's Disease Virus

Avian Diseases, 44(4), 770.

By: S. Reddy, R. Witter & I. Gimeno* 

author keywords: herpesvirus; Marek's disease; MDV; quantitative-competitive PCR
TL;DR: QC-PCR is extremely specific and sensitive to measure MDV DNA over a wide range and can be applied to in vivo studies of viral pathogenesis and the generally held idea that "hot" strains of MDV replicate earlier and better in birds. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: July 28, 2019

1999 journal article

An Acute Form of Transient Paralysis Induced by Highly Virulent Strains of Marek's Disease Virus

Avian Diseases, 43(4), 704.

By: R. Witter*, I. Gimeno* , W. Reed & L. Bacon

author keywords: Marek's disease; transient paralysis; chicken; central nervous system; pathotype
TL;DR: Acute TP appears to be one component in the pathogenesis of the early mortality syndrome, a previously described immunodepressive disease induced by inoculation of 1-day-old chicks with highly virulent Marek's disease virus strains. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, ORCID, Web Of Science
Added: July 28, 2019

1999 journal article

Evidence for Marek's disease in turkeys in Germany: Detection of MDVH serotype 1 using the polymerase chain reaction

Acta Virologica, 43, 143–147.

By: K. Voelckel, E. Bertram, I. Gimeno , U. Neumann & E. Kaleta

Source: NC State University Libraries
Added: November 4, 2019

1999 journal article

Four Distinct Neurologic Syndromes in Marek's Disease: Effect of Viral Strain and Pathotype

Avian Diseases, 43(4), 721.

By: I. Gimeno* , R. Witter & W. Reed

author keywords: Marek's disease; transient paralysis; pathotype; pathogenesis; chicken; central nervous system
TL;DR: It is confirmed that the central nervous system is an important target organ for MDV resulting in several distinct clinical manifestations and suggests that neurologic responses in antibody-free chickens might be a useful criterion for virus pathotyping. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, ORCID, Web Of Science
Added: July 28, 2019

Employment

Updated: October 25th, 2023 15:23

North Carolina State University RALEIGH, North Carolina, US
Professor Population Health and Pathobiology

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