Works (37)
Updated: July 5th, 2023 16:04
2012 journal article
In vitro biodistribution of silver nanoparticles in isolated perfused porcine skin flaps
JOURNAL OF APPLIED TOXICOLOGY, 32(11), 913–919.
Contributors: T. Leavens n , N. Monteiro-Riviere n , n, J. Brooks n, S. Oldenburg* & J. Riviere n
author keywords: silver nanoparticles; biodistribution; skin
MeSH headings : Animals; Metal Nanoparticles / chemistry; Nanoparticles / chemistry; Perfusion; Silver / chemistry; Silver / pharmacokinetics; Skin / metabolism; Swine / metabolism; Tissue Distribution
TL;DR:
The objective of the present study was to quantify the local biodistribution of two types of Ag nanoparticles, Ag‐citrate and Ag‐silica, in the isolated perfused porcine skin flap (IPPSF), and found no detectable elimination of Ag from the system.
(via Semantic Scholar)
open access via europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2012 journal article
LACK OF HYDROXYLATED FULLERENE TOXICITY AFTER INTRAVENOUS ADMINISTRATION TO FEMALE SPRAGUE-DAWLEY RATS
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, 75(7), 367–373.
Contributors: N. Monteiro-Riviere n , K. Linder n, n, J. Saathoff n, X. Xia n & J. Riviere n
MeSH headings : Animals; Blood Chemical Analysis; Drug Administration Schedule; Female; Fullerenes / administration & dosage; Fullerenes / chemistry; Fullerenes / toxicity; Injections, Intravenous; Liver / drug effects; Lymphocytes / drug effects; Nanoparticles / administration & dosage; Nanoparticles / chemistry; Nanoparticles / toxicity; Rats; Rats, Sprague-Dawley; Thymus Gland / drug effects; Toxicity Tests, Acute; Urinalysis
TL;DR:
These experiments suggest that this fullerol was well tolerated after iv administration to rats, and no clinically significant chemistry changes were observed after treatment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2012 journal article
Oxidative Stress and Dermal Toxicity of Iron Oxide Nanoparticles In Vitro
CELL BIOCHEMISTRY AND BIOPHYSICS, 67(2), 461–476.
Contributors: A. Murray*, E. Kisin*, n, S. Young*, M. Muhammed *, T. Burks*, A. Uheida*, A. Tkach*
author keywords: Nanoparticles; Skin exposure; Ultraviolet radiation; Iron oxide
MeSH headings : Biological Transport; Cell Survival / drug effects; Cytokines / metabolism; Glutathione / metabolism; Humans; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / metabolism; L-Lactate Dehydrogenase / metabolism; Magnetite Nanoparticles / chemistry; Magnetite Nanoparticles / toxicity; NF-kappa B / metabolism; Oxidative Stress / drug effects; Particle Size; Skin / cytology; Skin / drug effects; Transcription Factor AP-1 / metabolism
TL;DR:
Data indicate that co-exposure to UVB and SPIONs was associated with induction of oxidative stress and release of inflammatory mediators, verifying the need to thoroughly evaluate the adverse effects of UVB when evaluating dermal toxicity of engineered NPs on skin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2011 journal article
In vitro toxicity assessment of three hydroxylated fullerenes in human skin cells
TOXICOLOGY IN VITRO, 25(8), 2105–2112.
Contributors: J. Saathoff n, n, X. Xia n, J. Riviere n & N. Monteiro-Riviere n
author keywords: Hydroxylated fullerenes; Fullerenes; Cytotoxicity; Skin cells; Keratinocytes; Nanoparticles
MeSH headings : Biological Transport; Cell Survival; Cells, Cultured; Fullerenes / chemistry; Fullerenes / metabolism; Fullerenes / toxicity; Humans; Hydroxylation; Interleukin-8 / metabolism; Keratinocytes / drug effects; Keratinocytes / metabolism; Keratinocytes / ultrastructure; Microscopy, Electron, Transmission; Photoelectron Spectroscopy; Spectrometry, Fluorescence
TL;DR:
Results suggest that different hydroxylation of fullerenes caused no cytotoxicity or inflammation up to 8.55 μg/ml, and suggest that extrapolation across similar NP will be dependent upon surface chemistry and concentration which may affect the degree of agglomeration and thus biological effects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2011 journal article
Quantum dot penetration into viable human skin
NANOTOXICOLOGY, 6(2), 173–185.
Contributors: T. Prow *, N. Monteiro-Riviere n , n, J. Grice *, X. Chen *, X. Zhao *, W. Sanchez*, A. Gierden*
author keywords: Nanoparticles; exposure; nanotoxicology; surface chemistry
MeSH headings : Diffusion Chambers, Culture; Female; Humans; Hydrogen-Ion Concentration; Microscopy, Confocal; Nanoparticles; Particle Size; Polyethylene Glycols / metabolism; Polyethylene Glycols / pharmacology; Quantum Dots; Skin / chemistry; Skin / drug effects; Skin / metabolism; Skin Absorption / drug effects; Tissue Culture Techniques
TL;DR:
Systematic studies probing the effects of nanoparticle surface modification and formulation pH are important in nanotoxicology and nanomedicine and this study uses laser-scanning fluorescence confocal microscopy to evaluate nanoparticle penetration in viable excised human skin that was intact or tape-stripped.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2011 journal article
Safety Evaluation of Sunscreen Formulations Containing Titanium Dioxide and Zinc Oxide Nanoparticles in UVB Sunburned Skin: An In Vitro and In Vivo Study
TOXICOLOGICAL SCIENCES, 123(1), 264–280.
Contributors: N. Monteiro-Riviere n , K. Wiench *, R. Landsiedel *, S. Schulte *, n & J. Riviere n
author keywords: sunscreens; sunburn skin; titanium dioxide (TiO2); zinc oxide (ZnO); nanoparticles; skin penetration
MeSH headings : Animals; Erythema / etiology; Erythema / pathology; Erythema / prevention & control; In Vitro Techniques; Metal Nanoparticles / radiation effects; Metal Nanoparticles / toxicity; Metal Nanoparticles / ultrastructure; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Particle Size; Skin / drug effects; Skin / pathology; Skin / radiation effects; Skin / ultrastructure; Sunburn / drug therapy; Sunburn / etiology; Sunburn / pathology; Sunscreening Agents / pharmacokinetics; Sunscreening Agents / toxicity; Swine / physiology; Titanium / pharmacokinetics; Titanium / radiation effects; Titanium / toxicity; Ultraviolet Rays / adverse effects; Zinc Oxide / pharmacokinetics; Zinc Oxide / radiation effects; Zinc Oxide / toxicity
TL;DR:
UVB-damaged skin slightly enhanced TiO(2) NP or ZnO NP penetration in sunscreen formulations but no transdermal absorption was detected.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2009 journal article
Interactions of aluminum nanoparticles with human epidermal keratinocytes
JOURNAL OF APPLIED TOXICOLOGY, 30(3), 276–285.
Contributors: N. Monteiro-Riviere n , S. Oldenburg* & n
author keywords: aluminum; nanoparticles; human epidermal keratinocytes; nanotoxicity; viability assays; cytokine
MeSH headings : Aluminum / analysis; Aluminum / chemistry; Aluminum / toxicity; Artifacts; Cell Survival / drug effects; Cells, Cultured; Humans; Indicators and Reagents / chemistry; Inflammation Mediators / metabolism; Keratinocytes / drug effects; Keratinocytes / metabolism; Keratinocytes / ultrastructure; Metal Nanoparticles / chemistry; Metal Nanoparticles / toxicity; Metal Nanoparticles / ultrastructure; Microscopy, Electron, Transmission; Osmolar Concentration; Particle Size; Reproducibility of Results; Spectrophotometry; Temperature; Vacuoles / ultrastructure
TL;DR:
The difficulties involved in assessing the biological safety of nanomaterials such as Al NP due to media‐ and temperature‐dependent particle agglomeration and nanoparticle interactions with biomarkers of cytotoxicity are illustrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2008 journal article
Limitations and relative utility of screening assays to assess engineered nanoparticle toxicity in a human cell line
TOXICOLOGY AND APPLIED PHARMACOLOGY, 234(2), 222–235.
Contributors: N. Monteiro-Riviere n , n & L. Zhang n
author keywords: Carbon; Nanomaterials; Carbon black; Single-walled carbon nanotubes; C-60; nC(60); Quantum dots; Calcein AM; Live/Dead; NR; MTT; Celltiter 96 (R) AQueous One; Alamar Blue; Celltiter-Blue (R); CytoTox One (TM); Flow cytometry; Human epidermal keratinocytes; Toxicity; Viability assays
MeSH headings : Cell Line; Cell Survival / drug effects; Drug Evaluation, Preclinical; Flow Cytometry; Fluoresceins; Fluorescent Dyes; Humans; Keratinocytes / drug effects; Light; Microscopy, Electron, Transmission; Nanoparticles / toxicity; Oxazines; Quantum Dots; Scattering, Radiation; Spectrophotometry, Ultraviolet; Tetrazolium Salts; Thiazoles; Trypan Blue; Xanthenes
TL;DR:
This study shows that, unlike small molecules, CNM interact with assay markers to cause variable results with classical toxicology assays and may not be suitable for assessing nanoparticle cytotoxicity, therefore, more than one assay may be required when determining nanoparticle toxicity for risk assessment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2007 journal article
Inhibition of jet fuel aliphatic hydrocarbon induced toxicity in human epidermal keratinocytes
JOURNAL OF APPLIED TOXICOLOGY, 28(4), 543–553.
Contributors: n, N. Monteiro-Riviere n & J. Riviere n
author keywords: jet fuel; JP-8; skin toxicity; S-8; NF-kappa B; parthenolide; isohelenin; substance P; SB 203580; recombinant human IL-10
MeSH headings : Alkanes / toxicity; Anti-Inflammatory Agents / metabolism; Anti-Inflammatory Agents / pharmacology; Cell Survival / drug effects; Cells, Cultured; Cytokines / metabolism; Humans; Hydrocarbons / toxicity; Imidazoles / pharmacology; Interleukin-10 / metabolism; Irritants / toxicity; Keratinocytes / drug effects; Keratinocytes / metabolism; Keratinocytes / pathology; NF-kappa B / antagonists & inhibitors; NF-kappa B / metabolism; Protein Kinase Inhibitors / pharmacology; Pyridines / pharmacology; Recombinant Proteins / metabolism; Sesquiterpenes / pharmacology; Substance P / metabolism; Time Factors
TL;DR:
This study shows that inhibiting NF‐κB, which appears to play a role in cytokine production in HC‐exposed HEK in vitro, may reduce the inflammatory effect of HC in vivo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2006 journal article
Dermatological effects of chronic exposure to 7,12-dimethylbenz[a]anthracene (DMBA) or N-methyl-N-nitrosoguanidine (MNNG) in swine
CUTANEOUS AND OCULAR TOXICOLOGY, 25(2), 103–119.
Contributors: N. Monteiro-Riviere n , n, V. Hedgpeth n, B. Mosteller n & J. Piedrahita n
author keywords: DMBA; MNNG; skin cancer; swine
MeSH headings : 9,10-Dimethyl-1,2-benzanthracene / toxicity; Analysis of Variance; Animals; Cocarcinogenesis; Female; Methylnitronitrosoguanidine / toxicity; Neoplasms, Radiation-Induced; Skin / drug effects; Skin / radiation effects; Skin Neoplasms / chemically induced; Swine; Ultraviolet Rays
TL;DR:
The findings show that although chronic exposure to MNNG and DMBA, with or without UVB exposure, caused severe to mild dermatopathological changes, neither resulted in the development of skin carcinomas.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2006 journal article
Dermatotoxicity of cutting fluid mixtures: In vitro and in vivo studies
CUTANEOUS AND OCULAR TOXICOLOGY, 25(4), 235–247.
Contributors: N. Monteiro-Riviere n , n, B. Barlow n & R. Baynes n
author keywords: alkylbenzene sulfonate; cutting fluids; HEK; mixtures; ricinoleic acid; triazine; triethanolamine
MeSH headings : Animals; Cell Survival / drug effects; Cells, Cultured; Dermatitis, Contact / etiology; Dermatitis, Contact / metabolism; Dermatitis, Contact / pathology; Dermatitis, Occupational / etiology; Dermatitis, Occupational / metabolism; Dermatitis, Occupational / pathology; Dose-Response Relationship, Drug; Female; Humans; Interleukin-8 / metabolism; Kidney / cytology; Kidney / drug effects; Kidney / embryology; Metallurgy; Mineral Oil / pharmacokinetics; Mineral Oil / toxicity; Occupational Exposure; Skin / drug effects; Skin / metabolism; Skin / pathology; Skin Absorption; Swine
TL;DR:
Preliminary studies suggest that the biocide, TRI, is the more potent of the 4 performance additives in causing dermal irritation, and this may vary depending on whether the worker is exposed to a synthetic (PEG)- or MO-based fluid.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2005 journal article
Challenges for assessing carbon nanomaterial toxicity to the skin
CARBON, 44(6), 1070–1078.
Contributors: N. Monteiro-Riviere n & n
author keywords: carbon nanoparticles; bioactivity; scanning electron microscopy; transmission electron microscopy; aggregation
TL;DR:
It is suggested that carbon black may not be optimal control particles for assessing nanomaterial toxicity in epidermal cell culture systems due to the wide range of responses seen between the carbon black varieties.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2005 journal article
Effect of JP-8 jet fuel exposure on protein expression in human keratinocyte cells in culture
TOXICOLOGY LETTERS, 160(1), 8–21.
Contributors: F. Witzmann *, N. Monteiro-Riviere n , n, M. Kimpel*, N. Pedrick*, H. Ringham*, J. Riviere n
author keywords: jet fuel; keratinocyte; mass spectrometry; proteomics; toxicity; two-dimensional electrophoresis
MeSH headings : Cells, Cultured; Electrophoresis, Gel, Two-Dimensional; Humans; Hydrocarbons / pharmacology; Hydrocarbons / toxicity; Image Processing, Computer-Assisted; Interleukin-8 / biosynthesis; Keratinocytes / drug effects; Keratinocytes / metabolism; Occupational Exposure; Peptide Mapping; Protein Biosynthesis / drug effects; Proteome / biosynthesis; Proteome / drug effects; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
TL;DR:
To examine the effect of JP-8 administration on the human epidermal keratinocyte (HEK) proteome, a two-dimensional electrophoretic approach combined with mass spectrometric-based protein identification and Peptide mass fingerprint identification of effected proteins revealed a variety of functional implications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2005 journal article
Surfactant effects on carbon nanotube interactions with human keratinocytes
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 1(4), 293–299.
Contributors: N. Monteiro-Riviere n , n, Y. Wang* & R. Nemanich n
author keywords: Surfactant; Multiwalled carbon nanotubes; Human epidermal keratinocytes
MeSH headings : Apoptosis / drug effects; Cell Survival / drug effects; Cells, Cultured; Colloids / administration & dosage; Colloids / chemistry; Dose-Response Relationship, Drug; Humans; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / physiology; Nanotubes, Carbon / adverse effects; Nanotubes, Carbon / chemistry; Surface-Active Agents / administration & dosage; Surface-Active Agents / chemistry
TL;DR:
The results suggest that the surfactant-MWCNT interaction is more complex than simple dispersion alone and should be investigated to determine the mode of interaction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2004 journal article
Multi-walled carbon nanotube interactions with human epidermal keratinocytes
TOXICOLOGY LETTERS, 155(3), 377–384.
Contributors: N. Monteiro-Riviere n , R. Nemanich n, n, Y. Wang n & J. Riviere n
author keywords: multi-wall carbon nanotubes; human epidermal keratinocytes; transmission electron microscopy; IL-8
MeSH headings : Cell Nucleus / ultrastructure; Cell Survival; Cells, Cultured; Cytoplasm / ultrastructure; Humans; Interleukin-8 / biosynthesis; Keratinocytes / drug effects; Keratinocytes / immunology; Keratinocytes / ultrastructure; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Nanotubes, Carbon / analysis; Nanotubes, Carbon / chemistry; Nanotubes, Carbon / ultrastructure
TL;DR:
Data clearly show that MWCNT, not derivatized nor optimized for biological applications, are capable of both localizing within and initiating an irritation response in a target epithelial cell that composes a primary route of occupational exposure for manufactured nanotubes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2003 journal article
Percutaneous absorption of 2,6-di-tert-butyl-4-nitrophenol (DBNP) in isolated perfused porcine skin
TOXICOLOGY IN VITRO, 17(3), 289–292.
Contributors: n, K. Still*, W. Jederberg*, R. Carpenter*, J. Riviere n, J. Brooks n, N. Monteiro-Riviere n
author keywords: 2,6-di-tert-butyl-4-nitrophenol; skin absorption; porcine skin; dermal exposure
MeSH headings : Absorption; Administration, Cutaneous; Air Pollution, Indoor; Animals; Antioxidants; Humans; Military Personnel; Nitrophenols / pharmacokinetics; Phenols / chemistry; Skin Physiological Phenomena; Static Electricity; Submarine Medicine; Swine
TL;DR:
DBNP absorption was minimal across all treatment groups, with the highest absorption detected being only 1.08% applied dose in an aqueous ethanol group, suggesting that there is minimal dermal exposure of DBNP when exposed topically to skin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2003 journal article
Skin toxicity of jet fuels: ultrastructural studies and the effects of substance P
TOXICOLOGY AND APPLIED PHARMACOLOGY, 195(3), 339–347.
Contributors: N. Monteiro-Riviere n , n & J. Riviere n
author keywords: skin; Jet A; JP-8; JP-8+100; substance P; jet fuels
MeSH headings : Administration, Cutaneous; Animals; Cell Line; Humans; Hydrocarbons / toxicity; Interleukin-8 / immunology; Keratinocytes / drug effects; Keratinocytes / immunology; Keratinocytes / ultrastructure; Kerosene / toxicity; Microscopy, Electron; Mitochondrial Swelling / drug effects; Mitochondrial Swelling / immunology; Skin / drug effects; Skin / immunology; Skin / ultrastructure; Substance P / immunology; Substance P / pharmacology; Swine
TL;DR:
The primary change seen after exposure to all fuels was low-level inflammation accompanied by formation of lipid droplets in various skin layers, mitochondrial and nucleolar changes, cleft formation in the intercellular lipid lamellar bilayers, as well as disorganization in the stratum granulosum-stratum corneum interface.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2001 journal article
Effect of selective lipid extraction from different body regions on epidermal barrier function
PHARMACEUTICAL RESEARCH, 18(7), 992–998.
author keywords: epidermal lipids; ceramides; lipid extraction; tape stripping; transepidermal water loss (TEWL); electron microscopy; membrane lipids
MeSH headings : Abdomen; Animals; Back; Epidermis / drug effects; Epidermis / metabolism; Epidermis / physiology; Epidermis / ultrastructure; Erythema / chemically induced; Erythema / metabolism; Erythema / pathology; Female; Groin; Lipid Metabolism; Skin Absorption / drug effects; Skin Irritancy Tests / methods; Solvents / administration & dosage; Swine; Water / metabolism
TL;DR:
It is suggested that strategies that could biochemically alter epidermal lipid composition may increase absorption of simultaneously administered topical compounds and may be useful to enhance drug delivery.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2001 journal article
Effects of short-term high-dose and low-dose dermal exposure to Jet A, JP-8 and JP-8 + 100 jet fuels
Journal of Applied Toxicology, 21(6), 485–494.
Contributors: N. Monteiro-Riviere n , n & J. Riviere n
author keywords: skin; jet fuels; Jet A; JP-8; JP-8+100; dermatopathology; dermatotoxicity; pig; hydrocarbon fuels
MeSH headings : Administration, Cutaneous; Aircraft; Animals; Cell Division / drug effects; Clothing; Edema / chemically induced; Edema / pathology; Epidermis / drug effects; Epidermis / pathology; Erythema / chemically induced; Erythema / pathology; Female; Humans; Hydrocarbons / administration & dosage; Hydrocarbons / toxicity; Kerosene / toxicity; Occupational Exposure; Swine; Water-Electrolyte Balance
TL;DR:
It is found that the high‐dose fabric‐soaked exposure at 5 days to Jet A, JP‐8 andJP‐8 + 100 fuels caused the greatest increase in cutaneous erythema, edema, epidermal thickness and rete peg depth compared with high‐ dose non‐occluded or low‐dose exposure under Hill Top occluded and non-occluded conditions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2001 article
Efficacy of topical phenol decontamination strategies on severity of acute phenol chemical burns and dermal absorption: in vitro and in vivo studies in pig skin
Monteiro-Riviere, N. A., Inman, A. O., Jackson, H., Dunn, B., & Dimond, S. (2001, May). TOXICOLOGY AND INDUSTRIAL HEALTH, Vol. 17, pp. 95–104.
Contributors: N. Monteiro-Riviere n , n, H. Jackson n, B. Dunn* & S. Dimond*
author keywords: chemical burns; dermal absorption; phenol; pig skin; skin decontamination
MeSH headings : Absorption; Animals; Burns, Chemical / therapy; Disease Models, Animal; Female; Phenol / adverse effects; Phenol / pharmacokinetics; Sclerosing Solutions / adverse effects; Sclerosing Solutions / pharmacokinetics; Severity of Illness Index; Skin; Soaps; Solvents; Swine; Water
TL;DR:
It was concluded that PEG 400 and 70% IPA were superior to the other treatments investigated and equally efficacious in the reduction of phenol-induced skin damage.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2001 journal article
Electron microscopic observations of stratum corneum intercellular lipids in normal and atopic dogs
VETERINARY PATHOLOGY, 38(6), 720–723.
Contributors: *, T. Olivry* , S. Dunston*, N. Monteiro-Riviere* & H. Gatto
author keywords: barrier defect; canine atopic dermatitis; dogs; lipid lamellae; ruthenium tetroxide
MeSH headings : Animals; Biopsy / veterinary; Dermatitis, Atopic / metabolism; Dermatitis, Atopic / pathology; Dermatitis, Atopic / veterinary; Dog Diseases / metabolism; Dog Diseases / pathology; Dogs; Female; Fixatives / chemistry; Lipid Metabolism; Male; Microscopy, Electron / veterinary; Pilot Projects; Ruthenium Compounds / chemistry; Skin / metabolism; Skin / pathology; Skin / ultrastructure
TL;DR:
Preliminary observations suggest that the epidermal lipid barrier is defective in atopic canine skin and should be corrected with nutritional and/or pharmacologic intervention.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2000 journal article
Characterization of sulfur mustard-induced toxicity by enzyme histochemistry in porcine skin
TOXICOLOGY METHODS, 10(2), 127–142.
Contributors: N. Monteiro-Riviere n & n
TL;DR:
ALP staining was found to be the most sensitive of the enzyme biomarkers in this study, since its intensity increases in response to mild insult and decreases inresponse to a more severe exposure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1999 journal article
Immunohistochemical characterization of the basement membrane epitopes in bis(2-chloroethyl) sulfide-induced toxicity in mouse ear skin
JOURNAL OF APPLIED TOXICOLOGY, 19(5), 313–328.
Contributors: N. Monteiro-Riviere n , n, M. Babin* & R. Casillas *
author keywords: epidermal-dermal junction epitopes; immunoelectron microscopy; immunofluorescence; mouse skin; sulfur mustard; basement membrane; cutaneous toxicity; blister
TL;DR:
The immunofluorescence and IEM results indicate that HD causes an undulating inconsistent separation in the uppermost lamina lucida with focal cleavage into the lower portion of the basal keratinocytes just above the plasma membrane.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1998 conference paper
Assessment of epidermal-dermal junction epitopes in the mouse ear vesicant model
Proceedings of the 1998 Medical Defense Bioscience Review, 1–13. Aberdeen, MD: U.S. Army Medical Research Institute of Chemical Defense.
Source: NC State University Libraries
Added: August 6, 2018
1997 journal article
Comparison of an in vitro skin model to normal human skin for dermatological research
MICROSCOPY RESEARCH AND TECHNIQUE, 37(3), 172–179.
Contributors: N. MonteiroRiviere n, n, T. Snider *, J. Blank* & D. Hobson*
author keywords: in vitro skin model; human skin; viability; cell culture; electron microscopy; morphology; skin
TL;DR:
The EpiDerm™ HSE, although exhibiting slight differences, was morphologically and biochemically similar to normal human epidermis and may be a valuable model in assessing the toxicology, metabolism, or pharmacology of nonvesicating compounds.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1997 journal article
The effects of altered media flow and glucose concentration on sulfur mustard toxicity in isolated perfused skin
In Vitro Toxicology, 10(2), 169–181.
Source: NC State University Libraries
Added: August 6, 2018
1997 journal article
Ultrastructural characterization of sulfur mustard-induced vesication in isolated perfused porcine skin
MICROSCOPY RESEARCH AND TECHNIQUE, 37(3), 229–241.
Contributors: N. MonteiroRiviere n & n
author keywords: microvesicle; blisters; sulfur mustard (bis(2-chloroethyl) sulfide); isolated perfused skin; vesication; histology; in vitro; skin; toxicology; pig; ultrastructure
TL;DR:
The IPPSF appears to be an appropriate in vitro model with which to study the pathogenesis of vesicant‐induced toxicity and appeared similar to human skin exposed to HD with the formation of macroscopic blisters and microscopic vesicles.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1995 journal article
INDIRECT IMMUNOHISTOCHEMISTRY AND IMMUNOELECTRON MICROSCOPY DISTRIBUTION OF 8 EPIDERMAL-DERMAL JUNCTION EPITOPES IN THE PIG AND IN ISOLATED-PERFUSED SKIN TREATED WITH BIS (2-CHLOROETHYL) SULFIDE
TOXICOLOGIC PATHOLOGY, 23(3), 313–325.
author keywords: PIG SKIN; IPPSF; DERMATOTOXICOLOGY; SULFUR MUSTARD; MORPHOLOGY; EPIDERMAL DERMAL JUNCTION; LAMININ; TYPE IV COLLAGEN; FIBRONECTIN; GB3; BULLOUS PEMPHIGOID; EPIDERMOLYSIS BULLOSA ACQUISITA; L3D; 19-DEJ-1
MeSH headings : Animals; Antibodies, Monoclonal / immunology; Basement Membrane / chemistry; Basement Membrane / drug effects; Basement Membrane / ultrastructure; Collagen / analysis; Epidermolysis Bullosa Acquisita / immunology; Epitopes / analysis; Female; Fibronectins / analysis; Immunohistochemistry; In Vitro Techniques; Laminin / analysis; Microscopy, Immunoelectron; Mustard Gas / toxicity; Skin / chemistry; Skin / drug effects; Skin / ultrastructure; Swine; Trihexosylceramides / analysis
TL;DR:
P pig skin and the IPPSF may be used to study HD-induced vesication and blistering diseases and the conservation of human epitopes in the EDJ of the pig further emphasizes the similarities between human skin and pig skin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
1995 report
Mechanisms of cutaneous vesication
In N. T. I. S. (Ed.), DAMD17-92-C-2071; NTIS, ADA305800 (Vol. 161, pp. 1–161). DAMD 17-92C-2071, NTIS Report, ADA 305800.
Ed(s): Ntis
Source: NC State University Libraries
Added: August 6, 2018
1994 journal article
Determination of physicochemical properties of phenol, p-nitrophenol, acetone and ethanol relevant to quantitating their percutaneous absorption in porcine skin
Research Communications in Chemical Pathology and Pharmacology, 83, 61–75.
Source: NC State University Libraries
Added: August 6, 2018
1994 journal article
Development and characterization of a novel skin model for cutaneous phototoxicology
Photodermatology, Photoimmunology & Photomedicine, 235–243.
Source: NC State University Libraries
Added: August 6, 2018
1994 journal article
IDENTIFICATION OF THE PATHWAY OF IONTOPHORETIC DRUG-DELIVERY - LIGHT AND ULTRASTRUCTURAL STUDIES USING MERCURIC-CHLORIDE IN PIGS
PHARMACEUTICAL RESEARCH, 11(2), 251–256.
author keywords: PIGS; IONTOPHORESIS; PATHWAY; DRUG DELIVERY; MERCURIC CHLORIDE; SKIN; LIGHT MICROSCOPY; ELECTRON MICROSCOPY
MeSH headings : Animals; Epidermis / metabolism; Epidermis / ultrastructure; Female; Iontophoresis; Mercuric Chloride / administration & dosage; Mercuric Chloride / pharmacokinetics; Microscopy, Electron; Skin / metabolism; Skin / ultrastructure; Skin Absorption; Swine
TL;DR:
The electron micrographs clearly revealed that mercuric chloride traversed the intact stratum corneum via an intercellular route, having implications for iontophoretic drug delivery, since they allow visualization of the functional "pores" predicted by mathematical models.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
1994 report
Mechanisms of cutaneous vesication
In DAMD17-92-C-2071; NTIS, ADA283085 (Vol. 114, pp. 1–114). DAMD 17-92-C-2071, NTIS Report, ADA 283085.
Source: NC State University Libraries
Added: August 6, 2018
1993 conference paper
Studies on the pathogenesis of bis (2-chloroethyl) sulfide (HD) induced vesication in porcine skin
Proceedings of the Eighth Medical Defense Bioscience Review U.S. Army Medical Research Institute of Chemical Defense, 31–40. Aberdeen, MD: U.S. Army Medical Research Institute of Chemical Defense.
Source: NC State University Libraries
Added: August 6, 2018
1993 journal article
Topical penetration of piroxicam is dependent on the distribution of the local cutaneous vasculature
Pharmaceutical Research, 10, 1326–1331.
MeSH headings : Animals; Diffusion; Female; Piroxicam / pharmacokinetics; Regional Blood Flow / physiology; Skin / blood supply; Skin Absorption / physiology; Swine
TL;DR:
In conclusion, local delivery of topical drugs occurs independent of systemic absorption and the nature of the cutaneous vasculature at different sites must be taken into consideration for optimal delivery.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: NC State University Libraries, NC State University Libraries, ORCID
Added: August 6, 2018
1992 journal article
DETERMINATION OF LIDOCAINE CONCENTRATIONS IN SKIN AFTER TRANSDERMAL IONTOPHORESIS - EFFECTS OF VASOACTIVE DRUGS
PHARMACEUTICAL RESEARCH, 9(2), 211–214.
Contributors: J. Riviere n, N. Monteiroriviere n & n
author keywords: LIDOCAINE; IONTOPHORESIS; TRANSDERMAL; PERCUTANEOUS ABSORPTION; SKIN DEPOT
MeSH headings : Administration, Cutaneous; Animals; Electrodes; Female; Iontophoresis; Lidocaine / analysis; Lidocaine / pharmacokinetics; Models, Biological; Norepinephrine / pharmacology; Skin / anatomy & histology; Skin / chemistry; Skin / drug effects; Skin Absorption / drug effects; Swine / metabolism; Tolazoline / pharmacology; Vasoconstrictor Agents / pharmacology; Vasodilator Agents / pharmacology
TL;DR:
The hypothesis that coiontophoresis of vasoactive drugs modulates the transdermal delivery of lidocaine, in part by altering the cutaneous “depot,” is supported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1992 journal article
ENZYMATIC AND IMMUNOHISTOCHEMICAL STUDIES ON THE ROLE OF CYTOCHROME-P450 AND THE FLAVIN-CONTAINING MONOOXYGENASE OF MOUSE SKIN IN THE METABOLISM OF PESTICIDES AND OTHER XENOBIOTICS
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 43(1), 53–66.
Contributors: K. Venkatesh n, P. Levi n, n, N. Monteiroriviere n, R. Misra n & E. Hodgson n
TL;DR:
Although the overall phorate sulfoxidation rate in mouse skin microsomes was only 3 to 4% of the rate seen in liver, FMO appears to assume a greater relative role to P450 in the metabolic processes in skin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
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