Alfred O. Inman

Works (37)

Updated: February 10th, 2025 14:29

2012 article

In vitro biodistribution of silver nanoparticles in isolated perfused porcine skin flaps

Leavens, T. L., Monteiro‐Riviere, N. A., Inman, A. O., Brooks, J. D., Oldenburg, S. J., & Riviere, J. E. (2012, July 4). Journal of Applied Toxicology, Vol. 32, pp. 913–919.

By: T. Leavens n , N. Monteiro‐Riviere n , A. Inman n, J. Brooks n, S. Oldenburg* & J. Riviere n

Contributors: T. Leavens n , N. Monteiro-Riviere n , A. Inman n, J. Brooks n, S. Oldenburg* & J. Riviere n

author keywords: silver nanoparticles; biodistribution; skin
MeSH headings : Animals; Metal Nanoparticles / chemistry; Nanoparticles / chemistry; Perfusion; Silver / chemistry; Silver / pharmacokinetics; Skin / metabolism; Swine / metabolism; Tissue Distribution
topics (OpenAlex): Nanoparticles: synthesis and applications; Healthcare and Environmental Waste Management; Heavy Metal Exposure and Toxicity
TL;DR: The objective of the present study was to quantify the local biodistribution of two types of Ag nanoparticles, Ag‐citrate and Ag‐silica, in the isolated perfused porcine skin flap (IPPSF), and found no detectable elimination of Ag from the system. (via Semantic Scholar)
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Added: August 6, 2018

2012 article

Lack of Hydroxylated Fullerene Toxicity After Intravenous Administration to Female Sprague-Dawley Rats

Monteiro-Riviere, N. A., Linder, K. E., Inman, A. O., Saathoff, J. G., Xia, X.-R., & Riviere, J. E. (2012, April 1). Journal of Toxicology and Environmental Health, Vol. 75, pp. 367–373.

By: N. Monteiro-Riviere n , K. Linder n, A. Inman n, J. Saathoff n, X. Xia n & J. Riviere n

Contributors: N. Monteiro-Riviere n , K. Linder n, A. Inman n, J. Saathoff n, X. Xia n & J. Riviere n

MeSH headings : Animals; Blood Chemical Analysis; Drug Administration Schedule; Female; Fullerenes / administration & dosage; Fullerenes / chemistry; Fullerenes / toxicity; Injections, Intravenous; Liver / drug effects; Lymphocytes / drug effects; Nanoparticles / administration & dosage; Nanoparticles / chemistry; Nanoparticles / toxicity; Rats; Rats, Sprague-Dawley; Thymus Gland / drug effects; Toxicity Tests, Acute; Urinalysis
topics (OpenAlex): Fullerene Chemistry and Applications; Anesthesia and Neurotoxicity Research; Nanoparticles: synthesis and applications
TL;DR: These experiments suggest that this fullerol was well tolerated after iv administration to rats, and no clinically significant chemistry changes were observed after treatment. (via Semantic Scholar)
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Added: August 6, 2018

2012 article

Oxidative Stress and Dermal Toxicity of Iron Oxide Nanoparticles In Vitro

Murray, A. R., Kisin, E., Inman, A., Young, S.-H., Muhammed, M., Burks, T., … Shvedova, A. A. (2012, June 4). Cell Biochemistry and Biophysics, Vol. 67, pp. 461–476.

By: A. Murray*, E. Kisin*, A. Inman n, S. Young*, M. Muhammed *, T. Burks*, A. Uheida*, A. Tkach* ...

Contributors: A. Murray*, E. Kisin*, A. Inman n, S. Young*, M. Muhammed *, T. Burks*, A. Uheida*, A. Tkach* ...

author keywords: Nanoparticles; Skin exposure; Ultraviolet radiation; Iron oxide
MeSH headings : Biological Transport; Cell Survival / drug effects; Cytokines / metabolism; Glutathione / metabolism; Humans; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / metabolism; L-Lactate Dehydrogenase / metabolism; Magnetite Nanoparticles / chemistry; Magnetite Nanoparticles / toxicity; NF-kappa B / metabolism; Oxidative Stress / drug effects; Particle Size; Skin / cytology; Skin / drug effects; Transcription Factor AP-1 / metabolism
topics (OpenAlex): Pesticide Exposure and Toxicity; Retinoids in leukemia and cellular processes; Skin Protection and Aging
TL;DR: Data indicate that co-exposure to UVB and SPIONs was associated with induction of oxidative stress and release of inflammatory mediators, verifying the need to thoroughly evaluate the adverse effects of UVB when evaluating dermal toxicity of engineered NPs on skin. (via Semantic Scholar)
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Added: August 6, 2018

2011 article

In vitro toxicity assessment of three hydroxylated fullerenes in human skin cells

Saathoff, J. G., Inman, A. O., Xia, X. R., Riviere, J. E., & Monteiro-Riviere, N. A. (2011, September 23). Toxicology in Vitro, Vol. 25, pp. 2105–2112.

By: J. Saathoff n, A. Inman n, X. Xia n, J. Riviere n & N. Monteiro-Riviere n 

Contributors: J. Saathoff n, A. Inman n, X. Xia n, J. Riviere n & N. Monteiro-Riviere n 

author keywords: Hydroxylated fullerenes; Fullerenes; Cytotoxicity; Skin cells; Keratinocytes; Nanoparticles
MeSH headings : Biological Transport; Cell Survival; Cells, Cultured; Fullerenes / chemistry; Fullerenes / metabolism; Fullerenes / toxicity; Humans; Hydroxylation; Interleukin-8 / metabolism; Keratinocytes / drug effects; Keratinocytes / metabolism; Keratinocytes / ultrastructure; Microscopy, Electron, Transmission; Photoelectron Spectroscopy; Spectrometry, Fluorescence
topics (OpenAlex): Fullerene Chemistry and Applications; Graphene and Nanomaterials Applications; Anesthesia and Neurotoxicity Research
TL;DR: Results suggest that different hydroxylation of fullerenes caused no cytotoxicity or inflammation up to 8.55 μg/ml, and suggest that extrapolation across similar NP will be dependent upon surface chemistry and concentration which may affect the degree of agglomeration and thus biological effects. (via Semantic Scholar)
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2011 article

Quantum dot penetration into viable human skin

Prow, T. W., Monteiro-Riviere, N. A., Inman, A. O., Grice, J. E., Chen, X., Zhao, X., … Roberts, M. S. (2011, April 1). Nanotoxicology, Vol. 6, pp. 173–185.

By: T. Prow *, N. Monteiro-Riviere n , A. Inman n, J. Grice *, X. Chen *, X. Zhao *, W. Sanchez*, A. Gierden* ...

Contributors: T. Prow *, N. Monteiro-Riviere n , A. Inman n, J. Grice *, X. Chen *, X. Zhao *, W. Sanchez*, A. Gierden* ...

author keywords: Nanoparticles; exposure; nanotoxicology; surface chemistry
MeSH headings : Diffusion Chambers, Culture; Female; Humans; Hydrogen-Ion Concentration; Microscopy, Confocal; Nanoparticles; Particle Size; Polyethylene Glycols / metabolism; Polyethylene Glycols / pharmacology; Quantum Dots; Skin / chemistry; Skin / drug effects; Skin / metabolism; Skin Absorption / drug effects; Tissue Culture Techniques
topics (OpenAlex): Quantum Dots Synthesis And Properties; Near-Field Optical Microscopy; Advancements in Transdermal Drug Delivery
TL;DR: Systematic studies probing the effects of nanoparticle surface modification and formulation pH are important in nanotoxicology and nanomedicine and this study uses laser-scanning fluorescence confocal microscopy to evaluate nanoparticle penetration in viable excised human skin that was intact or tape-stripped. (via Semantic Scholar)
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2011 article

Safety Evaluation of Sunscreen Formulations Containing Titanium Dioxide and Zinc Oxide Nanoparticles in UVB Sunburned Skin: An In Vitro and In Vivo Study

Monteiro-Riviere, N. A., Wiench, K., Landsiedel, R., Schulte, S., Inman, A. O., & Riviere, J. E. (2011, June 3). Toxicological Sciences, Vol. 123, pp. 264–280.

By: N. Monteiro-Riviere n , K. Wiench *, R. Landsiedel *, S. Schulte *, A. Inman n & J. Riviere n

Contributors: N. Monteiro-Riviere n , K. Wiench *, R. Landsiedel *, S. Schulte *, A. Inman n & J. Riviere n

author keywords: sunscreens; sunburn skin; titanium dioxide (TiO2); zinc oxide (ZnO); nanoparticles; skin penetration
MeSH headings : Animals; Erythema / etiology; Erythema / pathology; Erythema / prevention & control; In Vitro Techniques; Metal Nanoparticles / radiation effects; Metal Nanoparticles / toxicity; Metal Nanoparticles / ultrastructure; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Particle Size; Skin / drug effects; Skin / pathology; Skin / radiation effects; Skin / ultrastructure; Sunburn / drug therapy; Sunburn / etiology; Sunburn / pathology; Sunscreening Agents / pharmacokinetics; Sunscreening Agents / toxicity; Swine / physiology; Titanium / pharmacokinetics; Titanium / radiation effects; Titanium / toxicity; Ultraviolet Rays / adverse effects; Zinc Oxide / pharmacokinetics; Zinc Oxide / radiation effects; Zinc Oxide / toxicity
topics (OpenAlex): Skin Protection and Aging; Thermoregulation and physiological responses; Urban Green Space and Health
TL;DR: UVB-damaged skin slightly enhanced TiO(2) NP or ZnO NP penetration in sunscreen formulations but no transdermal absorption was detected. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2009 article

Interactions of aluminum nanoparticles with human epidermal keratinocytes

Monteiro‐Riviere, N. A., Oldenburg, S. J., & Inman, A. O. (2009, December 9). Journal of Applied Toxicology, Vol. 30, pp. 276–285.

By: N. Monteiro‐Riviere n , S. Oldenburg* & A. Inman n

Contributors: N. Monteiro-Riviere n , S. Oldenburg* & A. Inman n

author keywords: aluminum; nanoparticles; human epidermal keratinocytes; nanotoxicity; viability assays; cytokine
MeSH headings : Aluminum / analysis; Aluminum / chemistry; Aluminum / toxicity; Artifacts; Cell Survival / drug effects; Cells, Cultured; Humans; Indicators and Reagents / chemistry; Inflammation Mediators / metabolism; Keratinocytes / drug effects; Keratinocytes / metabolism; Keratinocytes / ultrastructure; Metal Nanoparticles / chemistry; Metal Nanoparticles / toxicity; Metal Nanoparticles / ultrastructure; Microscopy, Electron, Transmission; Osmolar Concentration; Particle Size; Reproducibility of Results; Spectrophotometry; Temperature; Vacuoles / ultrastructure
topics (OpenAlex): Aluminum toxicity and tolerance in plants and animals; Nanoparticles: synthesis and applications; Heavy Metal Exposure and Toxicity
TL;DR: The difficulties involved in assessing the biological safety of nanomaterials such as Al NP due to media‐ and temperature‐dependent particle agglomeration and nanoparticle interactions with biomarkers of cytotoxicity are illustrated. (via Semantic Scholar)
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2008 article

Limitations and relative utility of screening assays to assess engineered nanoparticle toxicity in a human cell line

Monteiro-Riviere, N. A., Inman, A. O., & Zhang, L. W. (2008, October 18). Toxicology and Applied Pharmacology, Vol. 234, pp. 222–235.

By: N. Monteiro-Riviere n , A. Inman n & L. Zhang n

Contributors: N. Monteiro-Riviere n , A. Inman n & L. Zhang n

author keywords: Carbon; Nanomaterials; Carbon black; Single-walled carbon nanotubes; C-60; nC(60); Quantum dots; Calcein AM; Live/Dead; NR; MTT; Celltiter 96 (R) AQueous One; Alamar Blue; Celltiter-Blue (R); CytoTox One (TM); Flow cytometry; Human epidermal keratinocytes; Toxicity; Viability assays
MeSH headings : Cell Line; Cell Survival / drug effects; Drug Evaluation, Preclinical; Flow Cytometry; Fluoresceins; Fluorescent Dyes; Humans; Keratinocytes / drug effects; Light; Microscopy, Electron, Transmission; Nanoparticles / toxicity; Oxazines; Quantum Dots; Scattering, Radiation; Spectrophotometry, Ultraviolet; Tetrazolium Salts; Thiazoles; Trypan Blue; Xanthenes
topics (OpenAlex): Nanoparticles: synthesis and applications; Anesthesia and Neurotoxicity Research; Graphene and Nanomaterials Applications
TL;DR: This study shows that, unlike small molecules, CNM interact with assay markers to cause variable results with classical toxicology assays and may not be suitable for assessing nanoparticle cytotoxicity, therefore, more than one assay may be required when determining nanoparticle toxicity for risk assessment. (via Semantic Scholar)
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2007 article

Inhibition of jet fuel aliphatic hydrocarbon induced toxicity in human epidermal keratinocytes

Inman, A. O., Monteiro‐Riviere, N. A., & Riviere, J. E. (2007, October 26). Journal of Applied Toxicology, Vol. 28, pp. 543–553.

By: A. Inman n, N. Monteiro‐Riviere n  & J. Riviere n

Contributors: A. Inman n, N. Monteiro-Riviere n  & J. Riviere n

author keywords: jet fuel; JP-8; skin toxicity; S-8; NF-kappa B; parthenolide; isohelenin; substance P; SB 203580; recombinant human IL-10
MeSH headings : Alkanes / toxicity; Anti-Inflammatory Agents / metabolism; Anti-Inflammatory Agents / pharmacology; Cell Survival / drug effects; Cells, Cultured; Cytokines / metabolism; Humans; Hydrocarbons / toxicity; Imidazoles / pharmacology; Interleukin-10 / metabolism; Irritants / toxicity; Keratinocytes / drug effects; Keratinocytes / metabolism; Keratinocytes / pathology; NF-kappa B / antagonists & inhibitors; NF-kappa B / metabolism; Protein Kinase Inhibitors / pharmacology; Pyridines / pharmacology; Recombinant Proteins / metabolism; Sesquiterpenes / pharmacology; Substance P / metabolism; Time Factors
topics (OpenAlex): Plant Toxicity and Pharmacological Properties; Natural product bioactivities and synthesis; Sesquiterpenes and Asteraceae Studies
TL;DR: This study shows that inhibiting NF‐κB, which appears to play a role in cytokine production in HC‐exposed HEK in vitro, may reduce the inflammatory effect of HC in vivo. (via Semantic Scholar)
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2006 article

Dermatological Effects of Chronic Exposure to 7,12-Dimethylbenz[A]Anthracene (DMBA) or N-Methyl-N-Nitrosoguanidine (MNNG) in Swine

Monteiro-Riviere, N., Inman, A., Hedgpeth, V., Mosteller, B., & Piedrahita, J. (2006, January 1). Cutaneous and Ocular Toxicology, Vol. 25, pp. 103–119.

By: N. Monteiro-Riviere* , A. Inman n, V. Hedgpeth n, B. Mosteller n & J. Piedrahita n 

Contributors: N. Monteiro-Riviere* , A. Inman n, V. Hedgpeth n, B. Mosteller n & J. Piedrahita n 

author keywords: DMBA; MNNG; skin cancer; swine
MeSH headings : 9,10-Dimethyl-1,2-benzanthracene / toxicity; Analysis of Variance; Animals; Cocarcinogenesis; Female; Methylnitronitrosoguanidine / toxicity; Neoplasms, Radiation-Induced; Skin / drug effects; Skin / radiation effects; Skin Neoplasms / chemically induced; Swine; Ultraviolet Rays
topics (OpenAlex): Carcinogens and Genotoxicity Assessment; Skin Protection and Aging; Indoor Air Quality and Microbial Exposure
TL;DR: The findings show that although chronic exposure to MNNG and DMBA, with or without UVB exposure, caused severe to mild dermatopathological changes, neither resulted in the development of skin carcinomas. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2006 article

Dermatotoxicity of Cutting Fluid Mixtures:In VitroandIn VivoStudies

Monteiro-Riviere, N. A., Inman, A. O., Barlow, B. M., & Baynes, R. E. (2006, January 1). Cutaneous and Ocular Toxicology, Vol. 25, pp. 235–247.

By: N. Monteiro-Riviere* , A. Inman n, B. Barlow n & R. Baynes n 

Contributors: N. Monteiro-Riviere* , A. Inman n, B. Barlow n & R. Baynes n 

author keywords: alkylbenzene sulfonate; cutting fluids; HEK; mixtures; ricinoleic acid; triazine; triethanolamine
MeSH headings : Animals; Cell Survival / drug effects; Cells, Cultured; Dermatitis, Contact / etiology; Dermatitis, Contact / metabolism; Dermatitis, Contact / pathology; Dermatitis, Occupational / etiology; Dermatitis, Occupational / metabolism; Dermatitis, Occupational / pathology; Dose-Response Relationship, Drug; Female; Humans; Interleukin-8 / metabolism; Kidney / cytology; Kidney / drug effects; Kidney / embryology; Metallurgy; Mineral Oil / pharmacokinetics; Mineral Oil / toxicity; Occupational Exposure; Skin / drug effects; Skin / metabolism; Skin / pathology; Skin Absorption; Swine
topics (OpenAlex): Contact Dermatitis and Allergies; Immunotoxicology and immune responses; Occupational exposure and asthma
TL;DR: Preliminary studies suggest that the biocide, TRI, is the more potent of the 4 performance additives in causing dermal irritation, and this may vary depending on whether the worker is exposed to a synthetic (PEG)- or MO-based fluid. (via Semantic Scholar)
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2005 article

Challenges for assessing carbon nanomaterial toxicity to the skin

Monteiro-Riviere, N. A., & Inman, A. O. (2005, December 22). Carbon, Vol. 44, pp. 1070–1078.

By: N. Monteiro-Riviere n  & A. Inman n

Contributors: N. Monteiro-Riviere n  & A. Inman n

author keywords: carbon nanoparticles; bioactivity; scanning electron microscopy; transmission electron microscopy; aggregation
topics (OpenAlex): Nanoparticles: synthesis and applications; Animal testing and alternatives; Microplastics and Plastic Pollution
TL;DR: It is suggested that carbon black may not be optimal control particles for assessing nanomaterial toxicity in epidermal cell culture systems due to the wide range of responses seen between the carbon black varieties. (via Semantic Scholar)
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2005 article

Effect of JP-8 jet fuel exposure on protein expression in human keratinocyte cells in culture

Witzmann, F. A., Monteiro-Riviere, N. A., Inman, A. O., Kimpel, M. A., Pedrick, N. M., Ringham, H. N., & Riviere, J. E. (2005, July 13). Toxicology Letters, Vol. 160, pp. 8–21.

By: F. Witzmann *, N. Monteiro-Riviere n , A. Inman n, M. Kimpel*, N. Pedrick*, H. Ringham*, J. Riviere n

Contributors: F. Witzmann *, N. Monteiro-Riviere n , A. Inman n, M. Kimpel*, N. Pedrick*, H. Ringham*, J. Riviere n

author keywords: jet fuel; keratinocyte; mass spectrometry; proteomics; toxicity; two-dimensional electrophoresis
MeSH headings : Cells, Cultured; Electrophoresis, Gel, Two-Dimensional; Humans; Hydrocarbons / pharmacology; Hydrocarbons / toxicity; Image Processing, Computer-Assisted; Interleukin-8 / biosynthesis; Keratinocytes / drug effects; Keratinocytes / metabolism; Occupational Exposure; Peptide Mapping; Protein Biosynthesis / drug effects; Proteome / biosynthesis; Proteome / drug effects; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
topics (OpenAlex): S100 Proteins and Annexins; Bacillus and Francisella bacterial research; Immunotoxicology and immune responses
TL;DR: To examine the effect of JP-8 administration on the human epidermal keratinocyte (HEK) proteome, a two-dimensional electrophoretic approach combined with mass spectrometric-based protein identification and Peptide mass fingerprint identification of effected proteins revealed a variety of functional implications. (via Semantic Scholar)
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2005 article

Surfactant effects on carbon nanotube interactions with human keratinocytes

Monteiro-Riviere, N. A., Inman, A. O., Wang, Y. Y., & Nemanich, R. J. (2005, December 1). Nanomedicine Nanotechnology Biology and Medicine, Vol. 1, pp. 293–299.

By: N. Monteiro-Riviere n , A. Inman n, Y. Wang* & R. Nemanich n

Contributors: N. Monteiro-Riviere n , A. Inman n, Y. Wang* & R. Nemanich n

author keywords: Surfactant; Multiwalled carbon nanotubes; Human epidermal keratinocytes
MeSH headings : Apoptosis / drug effects; Cell Survival / drug effects; Cells, Cultured; Colloids / administration & dosage; Colloids / chemistry; Dose-Response Relationship, Drug; Humans; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / physiology; Nanotubes, Carbon / adverse effects; Nanotubes, Carbon / chemistry; Surface-Active Agents / administration & dosage; Surface-Active Agents / chemistry
topics (OpenAlex): Nanoparticles: synthesis and applications; Immunotoxicology and immune responses
TL;DR: The results suggest that the surfactant-MWCNT interaction is more complex than simple dispersion alone and should be investigated to determine the mode of interaction. (via Semantic Scholar)
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2004 article

Multi-walled carbon nanotube interactions with human epidermal keratinocytes

Monteiro-Riviere, N. A., Nemanich, R. J., Inman, A. O., Wang, Y. Y., & Riviere, J. E. (2004, December 29). Toxicology Letters, Vol. 155, pp. 377–384.

By: N. Monteiro-Riviere n , R. Nemanich n, A. Inman n, Y. Wang n & J. Riviere n

Contributors: N. Monteiro-Riviere n , R. Nemanich n, A. Inman n, Y. Wang n & J. Riviere n

author keywords: multi-wall carbon nanotubes; human epidermal keratinocytes; transmission electron microscopy; IL-8
MeSH headings : Cell Nucleus / ultrastructure; Cell Survival; Cells, Cultured; Cytoplasm / ultrastructure; Humans; Interleukin-8 / biosynthesis; Keratinocytes / drug effects; Keratinocytes / immunology; Keratinocytes / ultrastructure; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Nanotubes, Carbon / analysis; Nanotubes, Carbon / chemistry; Nanotubes, Carbon / ultrastructure
topics (OpenAlex): Nanoparticles: synthesis and applications; Animal testing and alternatives; Immunotoxicology and immune responses
TL;DR: Data clearly show that MWCNT, not derivatized nor optimized for biological applications, are capable of both localizing within and initiating an irritation response in a target epithelial cell that composes a primary route of occupational exposure for manufactured nanotubes. (via Semantic Scholar)
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2003 article

Percutaneous absorption of 2,6-di-tert-butyl-4-nitrophenol (DBNP) in isolated perfused porcine skin

Inman, A. O., Still, K. R., Jederberg, W. W., Carpenter, R. L., Riviere, J. E., Brooks, J. D., & Monteiro-Riviere, N. A. (2003, April 7). Toxicology in Vitro, Vol. 17, pp. 289–292.

By: A. Inman*, K. Still*, W. Jederberg*, R. Carpenter*, J. Riviere n, J. Brooks n, N. Monteiro-Riviere n 

Contributors: A. Inman*, K. Still*, W. Jederberg*, R. Carpenter*, J. Riviere n, J. Brooks n, N. Monteiro-Riviere n 

author keywords: 2,6-di-tert-butyl-4-nitrophenol; skin absorption; porcine skin; dermal exposure
MeSH headings : Absorption; Administration, Cutaneous; Air Pollution, Indoor; Animals; Antioxidants; Humans; Military Personnel; Nitrophenols / pharmacokinetics; Phenols / chemistry; Skin Physiological Phenomena; Static Electricity; Submarine Medicine; Swine
topics (OpenAlex): Advancements in Transdermal Drug Delivery; Effects and risks of endocrine disrupting chemicals; Contact Dermatitis and Allergies
TL;DR: DBNP absorption was minimal across all treatment groups, with the highest absorption detected being only 1.08% applied dose in an aqueous ethanol group, suggesting that there is minimal dermal exposure of DBNP when exposed topically to skin. (via Semantic Scholar)
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6. Clean Water and Sanitation (OpenAlex)
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2003 article

Skin toxicity of jet fuels: ultrastructural studies and the effects of substance P

Monteiro-Riviere, N. A., Inman, A. O., & Riviere, J. E. (2003, December 4). Toxicology and Applied Pharmacology, Vol. 195, pp. 339–347.

By: N. Monteiro-Riviere n , A. Inman n & J. Riviere n

Contributors: N. Monteiro-Riviere n , A. Inman n & J. Riviere n

author keywords: skin; Jet A; JP-8; JP-8+100; substance P; jet fuels
MeSH headings : Administration, Cutaneous; Animals; Cell Line; Humans; Hydrocarbons / toxicity; Interleukin-8 / immunology; Keratinocytes / drug effects; Keratinocytes / immunology; Keratinocytes / ultrastructure; Kerosene / toxicity; Microscopy, Electron; Mitochondrial Swelling / drug effects; Mitochondrial Swelling / immunology; Skin / drug effects; Skin / immunology; Skin / ultrastructure; Substance P / immunology; Substance P / pharmacology; Swine
topics (OpenAlex): Advancements in Transdermal Drug Delivery; Pesticide Exposure and Toxicity; Contact Dermatitis and Allergies
TL;DR: The primary change seen after exposure to all fuels was low-level inflammation accompanied by formation of lipid droplets in various skin layers, mitochondrial and nucleolar changes, cleft formation in the intercellular lipid lamellar bilayers, as well as disorganization in the stratum granulosum-stratum corneum interface. (via Semantic Scholar)
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2001 article

Effect of Selective Lipid Extraction from Different Body Regions on Epidermal Barrier Function

Monteiro-Riviere, N. A., Inman, A. O., Mak, V., Wertz, P., & Riviere, J. E. (2001, July 1). Pharmaceutical Research.

By: N. Monteiro-Riviere n , A. Inman n, V. Mak*, P. Wertz & J. Riviere n

author keywords: epidermal lipids; ceramides; lipid extraction; tape stripping; transepidermal water loss (TEWL); electron microscopy; membrane lipids
MeSH headings : Abdomen; Animals; Back; Epidermis / drug effects; Epidermis / metabolism; Epidermis / physiology; Epidermis / ultrastructure; Erythema / chemically induced; Erythema / metabolism; Erythema / pathology; Female; Groin; Lipid Metabolism; Skin Absorption / drug effects; Skin Irritancy Tests / methods; Solvents / administration & dosage; Swine; Water / metabolism
topics (OpenAlex): Dermatology and Skin Diseases; Advancements in Transdermal Drug Delivery; Essential Oils and Antimicrobial Activity
TL;DR: It is suggested that strategies that could biochemically alter epidermal lipid composition may increase absorption of simultaneously administered topical compounds and may be useful to enhance drug delivery. (via Semantic Scholar)
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2001 journal article

Effects of short-term high-dose and low-dose dermal exposure to Jet A, JP-8 and JP-8 + 100 jet fuels

Journal of Applied Toxicology, 21(6), 485–494.

By: N. Monteiro-Riviere n , A. Inman n & J. Riviere n

Contributors: N. Monteiro-Riviere n , A. Inman n & J. Riviere n

author keywords: skin; jet fuels; Jet A; JP-8; JP-8+100; dermatopathology; dermatotoxicity; pig; hydrocarbon fuels
MeSH headings : Administration, Cutaneous; Aircraft; Animals; Cell Division / drug effects; Clothing; Edema / chemically induced; Edema / pathology; Epidermis / drug effects; Epidermis / pathology; Erythema / chemically induced; Erythema / pathology; Female; Humans; Hydrocarbons / administration & dosage; Hydrocarbons / toxicity; Kerosene / toxicity; Occupational Exposure; Swine; Water-Electrolyte Balance
topics (OpenAlex): Carcinogens and Genotoxicity Assessment; Pesticide Exposure and Toxicity; Immunotoxicology and immune responses
TL;DR: It is found that the high‐dose fabric‐soaked exposure at 5 days to Jet A, JP‐8 andJP‐8 + 100 fuels caused the greatest increase in cutaneous erythema, edema, epidermal thickness and rete peg depth compared with high‐ dose non‐occluded or low‐dose exposure under Hill Top occluded and non-occluded conditions. (via Semantic Scholar)
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2001 article

Efficacy of topical phenol decontamination strategies on severity of acute phenol chemical burns and dermal absorption: in vitro and in vivo studies in pig skin

Monteiro-Riviere, N. A., Inman, A. O., Jackson, H., Dunn, B., & Dimond, S. (2001, May 1). Toxicology and Industrial Health, Vol. 17, pp. 95–104.

By: N. Monteiro-Riviere n , A. Inman n, H. Jackson n, B. Dunn* & S. Dimond*

Contributors: N. Monteiro-Riviere n , A. Inman n, H. Jackson n, B. Dunn* & S. Dimond*

author keywords: chemical burns; dermal absorption; phenol; pig skin; skin decontamination
MeSH headings : Absorption; Animals; Burns, Chemical / therapy; Disease Models, Animal; Female; Phenol / adverse effects; Phenol / pharmacokinetics; Sclerosing Solutions / adverse effects; Sclerosing Solutions / pharmacokinetics; Severity of Illness Index; Skin; Soaps; Solvents; Swine; Water
topics (OpenAlex): Advancements in Transdermal Drug Delivery; Animal testing and alternatives; Wound Healing and Treatments
TL;DR: It was concluded that PEG 400 and 70% IPA were superior to the other treatments investigated and equally efficacious in the reduction of phenol-induced skin damage. (via Semantic Scholar)
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6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2001 article

Electron Microscopic Observations of Stratum Corneum Intercellular Lipids in Normal and Atopic Dogs

Inman, A. O., Olivry, T., Dunston, S. M., Monteiro-Riviere, N. A., & Gatto, H. (2001, November 1). Veterinary Pathology, Vol. 38, pp. 720–723.

By: A. Inman*, T. Olivry* , S. Dunston*, N. Monteiro-Riviere*  & H. Gatto

Contributors: A. Inman*, T. Olivry* , S. Dunston*, N. Monteiro-Riviere*  & H. Gatto

author keywords: barrier defect; canine atopic dermatitis; dogs; lipid lamellae; ruthenium tetroxide
MeSH headings : Animals; Biopsy / veterinary; Dermatitis, Atopic / metabolism; Dermatitis, Atopic / pathology; Dermatitis, Atopic / veterinary; Dog Diseases / metabolism; Dog Diseases / pathology; Dogs; Female; Fixatives / chemistry; Lipid Metabolism; Male; Microscopy, Electron / veterinary; Pilot Projects; Ruthenium Compounds / chemistry; Skin / metabolism; Skin / pathology; Skin / ultrastructure
topics (OpenAlex): Dermatology and Skin Diseases; Advancements in Transdermal Drug Delivery; Contact Dermatitis and Allergies
TL;DR: Preliminary observations suggest that the epidermal lipid barrier is defective in atopic canine skin and should be corrected with nutritional and/or pharmacologic intervention. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2000 article

CHARACTERIZATION OF SULFUR MUSTARD–INDUCED TOXICITY BY ENZYME HISTOCHEMISTRY IN PORCINE SKIN

Monteiro-Riviere, N. A., & Inman, A. O. (2000, January 1). Toxicology Methods, Vol. 10, pp. 127–142.

By: N. Monteiro-Riviere n  & A. Inman n

Contributors: N. Monteiro-Riviere n  & A. Inman n

topics (OpenAlex): Pesticide Exposure and Toxicity; Environmental Toxicology and Ecotoxicology; Pesticide and Herbicide Environmental Studies
TL;DR: ALP staining was found to be the most sensitive of the enzyme biomarkers in this study, since its intensity increases in response to mild insult and decreases inresponse to a more severe exposure. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

1999 article

Immunohistochemical characterization of the basement membrane epitopes in bis(2-chloroethyl) sulfide-induced toxicity in mouse ear skin

Monteiro-Riviere, N. A., Inman, A. O., Babin, M. C., & Casillas, R. P. (1999, September 1). Journal of Applied Toxicology, Vol. 19, pp. 313–328.

By: N. Monteiro-Riviere n , A. Inman n, M. Babin* & R. Casillas *

Contributors: N. Monteiro-Riviere n , A. Inman n, M. Babin* & R. Casillas *

author keywords: epidermal-dermal junction epitopes; immunoelectron microscopy; immunofluorescence; mouse skin; sulfur mustard; basement membrane; cutaneous toxicity; blister
topics (OpenAlex): Autoimmune Bullous Skin Diseases; Mast cells and histamine; Contact Dermatitis and Allergies
TL;DR: The immunofluorescence and IEM results indicate that HD causes an undulating inconsistent separation in the uppermost lamina lucida with focal cleavage into the lower portion of the basal keratinocytes just above the plasma membrane. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

1998 conference paper

Assessment of epidermal-dermal junction epitopes in the mouse ear vesicant model

Proceedings of the 1998 Medical Defense Bioscience Review, 1–13. Aberdeen, MD: U.S. Army Medical Research Institute of Chemical Defense.

By: N. Monteiro-Riviere , A. Inman, M. Babin & R. Casillas

Source: NC State University Libraries
Added: August 6, 2018

1997 article

Comparison of an in vitro skin model to normal human skin for dermatological research

Monteiro-Riviere, N. A., Inman, A. O., Snider, T. H., Blank, J. A., & Hobson, D. W. (1997, May 1). Microscopy Research and Technique, Vol. 37, pp. 172–179.

By: N. Monteiro-Riviere n , A. Inman n, T. Snider *, J. Blank* & D. Hobson*

Contributors: N. MonteiroRiviere n , A. Inman n, T. Snider *, J. Blank* & D. Hobson*

author keywords: in vitro skin model; human skin; viability; cell culture; electron microscopy; morphology; skin
topics (OpenAlex): Advancements in Transdermal Drug Delivery; Dermatology and Skin Diseases; Skin Protection and Aging
TL;DR: The EpiDerm™ HSE, although exhibiting slight differences, was morphologically and biochemically similar to normal human epidermis and may be a valuable model in assessing the toxicology, metabolism, or pharmacology of nonvesicating compounds. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

1997 journal article

The effects of altered media flow and glucose concentration on sulfur mustard toxicity in isolated perfused skin

In Vitro Toxicology, 10(2), 169–181.

By: J. Riviere, N. Monteiro-Riviere  & A. Inman

Source: NC State University Libraries
Added: August 6, 2018

1997 article

Ultrastructural characterization of sulfur mustard-induced vesication in isolated perfused porcine skin

Monteiro-Riviere, N. A., & Inman, A. O. (1997, May 1). Microscopy Research and Technique, Vol. 37, pp. 229–241.

By: N. Monteiro-Riviere n  & A. Inman n

Contributors: N. MonteiroRiviere n  & A. Inman n

author keywords: microvesicle; blisters; sulfur mustard (bis(2-chloroethyl) sulfide); isolated perfused skin; vesication; histology; in vitro; skin; toxicology; pig; ultrastructure
topics (OpenAlex): Bee Products Chemical Analysis; Pesticide Exposure and Toxicity; Contact Dermatitis and Allergies
TL;DR: The IPPSF appears to be an appropriate in vitro model with which to study the pathogenesis of vesicant‐induced toxicity and appeared similar to human skin exposed to HD with the formation of macroscopic blisters and microscopic vesicles. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

1995 article

Indirect Immunohistochemistry and Immunoelectron Microscopy Distribution of Eight Epidermal-Dermal Junction Epitopes in the Pig and in Isolated Perfused Skin Treated with Bis (2-Chloroethyl) Sulfide

Monteiro-Riviere, N. A., & Inman, A. O. (1995, May 1). Toxicologic Pathology, Vol. 23, pp. 313–325.

By: N. Monteiro-Riviere n  & A. Inman n

author keywords: PIG SKIN; IPPSF; DERMATOTOXICOLOGY; SULFUR MUSTARD; MORPHOLOGY; EPIDERMAL DERMAL JUNCTION; LAMININ; TYPE IV COLLAGEN; FIBRONECTIN; GB3; BULLOUS PEMPHIGOID; EPIDERMOLYSIS BULLOSA ACQUISITA; L3D; 19-DEJ-1
MeSH headings : Animals; Antibodies, Monoclonal / immunology; Basement Membrane / chemistry; Basement Membrane / drug effects; Basement Membrane / ultrastructure; Collagen / analysis; Epidermolysis Bullosa Acquisita / immunology; Epitopes / analysis; Female; Fibronectins / analysis; Immunohistochemistry; In Vitro Techniques; Laminin / analysis; Microscopy, Immunoelectron; Mustard Gas / toxicity; Skin / chemistry; Skin / drug effects; Skin / ultrastructure; Swine; Trihexosylceramides / analysis
topics (OpenAlex): Contact Dermatitis and Allergies; Skin and Cellular Biology Research; melanin and skin pigmentation
TL;DR: P pig skin and the IPPSF may be used to study HD-induced vesication and blistering diseases and the conservation of human epitopes in the EDJ of the pig further emphasizes the similarities between human skin and pig skin. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1995 report

Mechanisms of cutaneous vesication

In NTIS (Ed.), DAMD17-92-C-2071; NTIS, ADA305800 (Vol. 161, pp. 1–161). DAMD 17-92C-2071, NTIS Report, ADA 305800.

By: N. Monteiro-Riviere , J. Zhang, A. Inman & J. Riviere

Ed(s): Ntis

Source: NC State University Libraries
Added: August 6, 2018

1994 journal article

Determination of physicochemical properties of phenol, p-nitrophenol, acetone and ethanol relevant to quantitating their percutaneous absorption in porcine skin

Research Communications in Chemical Pathology and Pharmacology, 83, 61–75.

By: P. William, J. Brooks, A. Inman, N. Monteiro-Riviere  & J. Riviere

Source: NC State University Libraries
Added: August 6, 2018

1994 journal article

Development and characterization of a novel skin model for cutaneous phototoxicology

Photodermatology, Photoimmunology & Photomedicine, 235–243.

By: N. Monteiro-Riviere , A. Inman & J. Riviere

Source: NC State University Libraries
Added: August 6, 2018

1994 article

Identification of the Pathway of lontophoretic Drug Delivery: Light and Ultrastructural Studies Using Mercuric Chloride in Pigs

Monteiro-Riviere, N. A., Inman, A. O., & Riviere, J. E. (1994, February 1). Pharmaceutical Research, Vol. 11, pp. 251–256.

By: N. Monteiro-Riviere n , A. Inman n & J. Riviere n

author keywords: PIGS; IONTOPHORESIS; PATHWAY; DRUG DELIVERY; MERCURIC CHLORIDE; SKIN; LIGHT MICROSCOPY; ELECTRON MICROSCOPY
MeSH headings : Animals; Epidermis / metabolism; Epidermis / ultrastructure; Female; Iontophoresis; Mercuric Chloride / administration & dosage; Mercuric Chloride / pharmacokinetics; Microscopy, Electron; Skin / metabolism; Skin / ultrastructure; Skin Absorption; Swine
topics (OpenAlex): Advancements in Transdermal Drug Delivery; Bee Products Chemical Analysis; Advanced Drug Delivery Systems
TL;DR: The electron micrographs clearly revealed that mercuric chloride traversed the intact stratum corneum via an intercellular route, having implications for iontophoretic drug delivery, since they allow visualization of the functional "pores" predicted by mathematical models. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1994 report

Mechanisms of cutaneous vesication

In DAMD17-92-C-2071; NTIS, ADA283085 (Vol. 114, pp. 1–114). DAMD 17-92-C-2071, NTIS Report, ADA 283085.

By: N. Monteiro-Riviere , J. Zhang, A. Inman, J. Brooks & J. Riviere

Source: NC State University Libraries
Added: August 6, 2018

1993 conference paper

Studies on the pathogenesis of bis (2-chloroethyl) sulfide (HD) induced vesication in porcine skin

Proceedings of the Eighth Medical Defense Bioscience Review U.S. Army Medical Research Institute of Chemical Defense, 31–40. Aberdeen, MD: U.S. Army Medical Research Institute of Chemical Defense.

By: N. Monteiro-Riviere , A. Inman, J. Spoo, R. Rogers & J. Riviere

Source: NC State University Libraries
Added: August 6, 2018

1993 article

Topical Penetration of Piroxicam Is Dependent on the Distribution of the Local Cutaneous Vasculature

Monteiro-Riviere, N. A., Inman, A. O., Riviere, J. E., McNeill, S. C., & Francoeur, M. L. (1993, September 1). Pharmaceutical Research, Vol. 10, pp. 1326–1331.

By: N. Monteiro-Riviere* , A. Inman n, J. Riviere n, S. McNeill* & M. Francoeur*

MeSH headings : Animals; Diffusion; Female; Piroxicam / pharmacokinetics; Regional Blood Flow / physiology; Skin / blood supply; Skin Absorption / physiology; Swine
topics (OpenAlex): Nail Diseases and Treatments; Advancements in Transdermal Drug Delivery; Dermatology and Skin Diseases
TL;DR: In conclusion, local delivery of topical drugs occurs independent of systemic absorption and the nature of the cutaneous vasculature at different sites must be taken into consideration for optimal delivery. (via Semantic Scholar)
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Sources: NC State University Libraries, NC State University Libraries, ORCID
Added: August 6, 2018

1992 article

Determination of lidocaine concentrations in skin after transdermal iontophoresis: effects of vasoactive drugs.

Riviere, J. E., Monteiro‐Riviere, N. A., & Inman, A. O. (1992, January 1). Pharmaceutical Research, Vol. 9, pp. 211–214.

By: J. Riviere*, N. Monteiro‐Riviere n  & A. Inman n

Contributors: J. Riviere*, N. Monteiroriviere n  & A. Inman n

author keywords: LIDOCAINE; IONTOPHORESIS; TRANSDERMAL; PERCUTANEOUS ABSORPTION; SKIN DEPOT
MeSH headings : Administration, Cutaneous; Animals; Electrodes; Female; Iontophoresis; Lidocaine / analysis; Lidocaine / pharmacokinetics; Models, Biological; Norepinephrine / pharmacology; Skin / anatomy & histology; Skin / chemistry; Skin / drug effects; Skin Absorption / drug effects; Swine / metabolism; Tolazoline / pharmacology; Vasoconstrictor Agents / pharmacology; Vasodilator Agents / pharmacology
topics (OpenAlex): Advancements in Transdermal Drug Delivery; Nail Diseases and Treatments; Contact Dermatitis and Allergies
TL;DR: The hypothesis that coiontophoresis of vasoactive drugs modulates the transdermal delivery of lidocaine, in part by altering the cutaneous “depot,” is supported. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

1992 article

Enzymatic and immunohistochemical studies on the role of cytochrome P450 and the flavin-containing monooxygenase of mouse skin in the metabolism of pesticides and other xenobiotics

Venkatesh, K., Levi, P. E., Inman, A. O., Monteiro-Riviere, N. A., Misra, R., & Hodgson, E. (1992, May 1). Pesticide Biochemistry and Physiology, Vol. 43, pp. 53–66.

By: K. Venkatesh n, P. Levi n, A. Inman n, N. Monteiro-Riviere n , R. Misra  n & E. Hodgson n

Contributors: K. Venkatesh n, P. Levi n, A. Inman n, N. Monteiroriviere n , R. Misra  n & E. Hodgson n

topics (OpenAlex): Pharmacogenetics and Drug Metabolism; Drug Transport and Resistance Mechanisms; Pesticide and Herbicide Environmental Studies
TL;DR: Although the overall phorate sulfoxidation rate in mouse skin microsomes was only 3 to 4% of the rate seen in liver, FMO appears to assume a greater relative role to P450 in the metabolic processes in skin. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

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