Imran Rizvi

Works (17)

Updated: June 18th, 2024 05:03

2024 article

Overcoming the effects of fluid shear stress in ovarian cancer cell lines: Doxorubicin alone or photodynamic priming to target platinum resistance

Overchuk, M., Rickard, B. P., Tulino, J., Tan, X., Ligler, F. S., Huang, H.-C., & Rizvi, I. (2024, June 7). PHOTOCHEMISTRY AND PHOTOBIOLOGY.

By: M. Overchuk  n, B. Rickard *, J. Tulino n, X. Tan *, F. Ligler*, H. Huang *, I. Rizvi n

author keywords: benzoporphyrin derivative; cisplatin; doxorubicin; high-grade serous ovarian carcinoma; ovarian cancer; photodynamic priming
UN Sustainable Development Goal Categories
1. No Poverty (OpenAlex)
Source: Web Of Science
Added: June 17, 2024

2023 journal article

Development of a light emitting device for the treatment of peritoneal car- cinomatosis of ovarian origin by intracavitary photodynamic therapy

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 41.

By: M. Overchuk, M. Ruhi, B. Rickard, F. Ligler & I. Rizvi

author keywords: Photodynamic therapy; peritoneal carcinomatosis; ovarian cancer
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: May 22, 2023

2023 journal article

Exposure to select PFAS and PFAS mixtures alters response to platinum-based chemotherapy in endometrial cancer cell lines

ENVIRONMENTAL HEALTH, 22(1).

By: B. Rickard *, M. Overchuk n, J. Tulino n, X. Tan, F. Ligler*, V. Bae-Jump *, S. Fenton *, I. Rizvi n

author keywords: PFAS; Endometrial cancer; Therapy resistance; Carboplatin; Cisplatin; Mitochondria
TL;DR: Investigation of the effect of environmental exposures, specifically PFAS, on platinum-based chemotherapy response and mitochondrial function in endometrial cancer suggests that PFAS exposure may affect endometrial cancer cell mitochondrial functioning. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: January 2, 2024

2023 review

Methods to Evaluate Changes in Mitochondrial Structure and Function in Cancer

[Review of ]. CANCERS, 15(9).

By: B. Rickard *, M. Overchuk n, V. Chappell*, M. Kemal Ruhi *, P. Sinawang *, T. Nguyen Hoang*, D. Akin *, U. Demirci ...

author keywords: mitochondrial methods; bioenergetics; mitochondrial dysfunction; reactive species; mitochondrial function; mitochondrial structure; extracellular vesicles
TL;DR: Methods to evaluate the structural and functional parameters of mitochondrial health in the context of tumors and cancer cells are discussed, with a particular emphasis on gynecologic malignancies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, ORCID
Added: May 30, 2023

2023 journal article

Targeted PDT Combinations to Overcome Fluid Shear Stress-induced Plat- inum Resistance in Ovarian Cancer

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 41.

By: M. Overchuk n, M. Ruhi n, B. Rickard n, F. Ligler* & I. Rizvi n

author keywords: photodynamic therapy; ovarian cancer; benzoporphyrin derivative; chemoresistance; shear stress
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: May 22, 2023

2023 journal article

Transient fluid flow improves photoimmunoconjugate delivery and photoimmunotherapy efficacy

ISCIENCE, 26(8).

By: A. Sorrin*, K. Zhou*, K. May*, C. Liu *, K. McNaughton *, I. Rahman*, B. Liang *, I. Rizvi n, D. Roque *, H. Huang *

TL;DR: The fundamental role of fluid flow-induced shear stress in the anti-cancer effects of photoimmunotherapy is confirmed and enhanced phototoxicity compared to static conditions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 28, 2023

2022 journal article

Critical PDT theory II: Current concepts and indications

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 39.

By: D. Kessel *, G. Obaid * & I. Rizvi n

author keywords: Photodynamic therapy; Apoptosis; Photosensitization
MeSH headings : Humans; Neoplasms / drug therapy; Neoplasms / pathology; Photochemotherapy / methods; Photosensitizing Agents / therapeutic use
TL;DR: Current research efforts that improve clinical relevance and those that do not are provided, including those that describe phenomena that only reiterate what is already known. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 8, 2022

2022 journal article

Per- and poly-fluoroalkyl substances (PFAS) and female reproductive outcomes: PFAS elimination, endocrine-mediated effects, and disease

TOXICOLOGY, 465.

By: B. Rickard  n, I. Rizvi n & S. Fenton *

author keywords: PFAS; Female reproduction; Environmental contaminants; Endocrine disruption
MeSH headings : Endocrine Disruptors / adverse effects; Endocrine System Diseases / chemically induced; Endocrine System Diseases / metabolism; Endocrine System Diseases / physiopathology; Environmental Exposure / adverse effects; Environmental Pollutants / adverse effects; Female; Fertility / drug effects; Humans; Hydrocarbons, Fluorinated / adverse effects; Infertility, Female / chemically induced; Infertility, Female / metabolism; Infertility, Female / physiopathology; Menstrual Cycle / drug effects; Pregnancy; Pregnancy Complications / chemically induced; Pregnancy Complications / metabolism; Pregnancy Complications / physiopathology; Prognosis; Reproduction / drug effects; Risk Assessment; Risk Factors
TL;DR: The role of a variety of PFAS and PFAS mixtures in female reproductive tract dysfunction and disease is summarized and the role ofPFAS in breast, thyroid, and hypothalamic-pituitary-gonadal axis function is discussed as the interplay between these tissues may be critical in understanding the long-term reproductive health effects of PFas in women. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: November 29, 2021

2022 article

Photochemical Targeting of Mitochondria to Overcome Chemoresistance in Ovarian Cancer

Rickard, B. P., Overchuk, M., Obaid, G., Ruhi, M. K., Demirci, U., Fenton, S. E., … Rizvi, I. (2022, October 19). PHOTOCHEMISTRY AND PHOTOBIOLOGY.

By: B. Rickard *, M. Overchuk n, G. Obaid *, M. Ruhi *, U. Demirci *, S. Fenton *, J. Santos *, D. Kessel *, I. Rizvi n

UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: October 31, 2022

2022 article

Photodynamic Stromal Depletion Enhances Therapeutic Nanoparticle Delivery in 3D Pancreatic Ductal Adenocarcinoma Tumor Models

Karimnia, V., Stanley, M. E., Fitzgerald, C. T., Rizvi, I., Slack, F. J., & Celli, J. P. (2022, August 3). PHOTOCHEMISTRY AND PHOTOBIOLOGY.

By: V. Karimnia, M. Stanley n, C. Fitzgerald n, I. Rizvi n, F. Slack * & J. Celli

MeSH headings : Humans; Pancreatic Neoplasms / drug therapy; Carcinoma, Pancreatic Ductal / drug therapy; Nanoparticles; MicroRNAs / genetics; Cell Line, Tumor; RNA-Binding Proteins; Apoptosis Regulatory Proteins / metabolism; Apoptosis Regulatory Proteins / therapeutic use
TL;DR: Results in 3D tumor models suggest that PSD could be developed to enhance delivery of other cancer therapeutics and improve tumor response to treatment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 29, 2022

2022 journal article

Select Per- and Polyfluoroalkyl Substances (PFAS) Induce Resistance to Carboplatin in Ovarian Cancer Cell Lines

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(9).

By: B. Rickard *, X. Tan *, S. Fenton * & I. Rizvi n

author keywords: per- and polyfluoroalkyl substances; PFAS; ovarian cancer; platinum resistance; carboplatin; mitochondrial function
MeSH headings : Alkanesulfonic Acids / toxicity; Carboplatin / pharmacology; Carcinoma, Ovarian Epithelial; Cell Line; Environmental Pollutants / toxicity; Female; Fluorocarbons / toxicity; Humans; Ovarian Neoplasms / drug therapy
TL;DR: This is the first study to demonstrate that, at sub-cytotoxic concentrations, select PFAS and PFAS mixtures increased survival fraction in ovarian cancer cells following carboplatin treatment, indicative of platinum resistance. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, ORCID
Added: May 23, 2022

2021 journal article

Emerging biofabrication approaches for gastrointestinal organoids towards patient specific cancer models

CANCER LETTERS, 504, 116–124.

By: F. Soto *, C. Guimaraes *, R. Reis *, W. Franco *, I. Rizvi n & U. Demirci *

author keywords: Bioengineering; Organ on a chip; Self-assembly; Externally driven assembly; Personalized medicine
MeSH headings : Cell Differentiation; Gastrointestinal Tract / cytology; Humans; Models, Biological; Organoids / cytology; Precision Medicine; Tissue Engineering / methods
TL;DR: Development in three-dimensional (3D) artificial cell constructs to model gastrointestinal dynamics towards cancer diagnosis and the main challenges and possible risks regarding the potential translation of gastrointestinal organoids from laboratory settings to patient-specific models in clinical applications are outlined. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: April 5, 2021

2021 review

Malignant Ascites in Ovarian Cancer: Cellular, Acellular, and Biophysical Determinants of Molecular Characteristics and Therapy Response

[Review of ]. CANCERS, 13(17).

By: B. Rickard  n, C. Conrad*, A. Sorrin*, M. Ruhi  n, J. Reader *, S. Huang n, W. Franco *, G. Scarcelli * ...

author keywords: malignant ascites; epithelial ovarian cancer; chemoresistance; mechanical stress; flow-induced shear stress; photodynamic therapy; tumor microenvironment; transcoelomic metastases; tumor heterogeneity; epithelial to mesenchymal transition
TL;DR: The current understanding of malignant ascites is summarized, starting with an overview of ovarian cancer and ascites, followed by a description of the tools used to analyze the components of ascites and how these components modulate ovarian cancer biology. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: September 20, 2021

2021 journal article

Photodestruction of Stromal Fibroblasts Enhances Tumor Response to PDT in 3D Pancreatic Cancer Coculture Models

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 97(2), 416–426.

By: V. Karimnia *, I. Rizvi n, F. Slack * & J. Celli *

MeSH headings : Carcinoma, Pancreatic Ductal / drug therapy; Carcinoma, Pancreatic Ductal / pathology; Cell Line, Tumor; Coculture Techniques; Fibroblasts / pathology; Humans; Pancreatic Neoplasms / drug therapy; Pancreatic Neoplasms / pathology; Photochemotherapy; Stromal Cells / pathology
TL;DR: The results point to the potential for PDT to overcome tumor‐promoting stromal interactions associated with poor therapeutic response in PDAC, and increase response to PDT relative to homotypic cultures. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: November 16, 2020

2020 journal article

Vitamin D Receptor Activation and Photodynamic Priming Enables Durable Low-dose Chemotherapy

MOLECULAR CANCER THERAPEUTICS, 19(6), 1308–1319.

By: S. Anbil*, M. Pigula *, H. Huang *, S. Mallidi *, M. Broekgaarden *, Y. Baglo *, P. De Silva *, D. Simeone * ...

MeSH headings : Animals; Antineoplastic Agents / pharmacology; Apoptosis; Biomarkers, Tumor / genetics; Biomarkers, Tumor / metabolism; Calcitriol / analogs & derivatives; Calcitriol / pharmacology; Carcinoma, Pancreatic Ductal / drug therapy; Carcinoma, Pancreatic Ductal / metabolism; Carcinoma, Pancreatic Ductal / pathology; Carcinoma, Pancreatic Ductal / radiotherapy; Cell Proliferation; Chemokine CXCL12 / genetics; Chemokine CXCL12 / metabolism; Dermatologic Agents / pharmacology; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Mice, Nude; Pancreatic Neoplasms / drug therapy; Pancreatic Neoplasms / metabolism; Pancreatic Neoplasms / pathology; Pancreatic Neoplasms / radiotherapy; Photochemotherapy; Receptors, CXCR / genetics; Receptors, CXCR / metabolism; Receptors, CXCR4 / genetics; Receptors, CXCR4 / metabolism; Receptors, Calcitriol / genetics; Receptors, Calcitriol / metabolism; Tumor Cells, Cultured; Xenograft Model Antitumor Assays
TL;DR: A dual pronged approach to modulate the microenvironment of desmoplastic pancreatic tumors and enable significant dose deescalation of the FDA-approved chemotherapeutic nanoliposomal irinotecan (nal-IRI) without compromising tumor control is introduced. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: June 22, 2020

2019 journal article

Illuminating the Numbers: Integrating Mathematical Models to Optimize Photomedicine Dosimetry and Combination Therapies

FRONTIERS IN PHYSICS, 7.

By: B. Spring *, R. Lang *, E. Kercher*, I. Rizvi n, R. Wenham *, J. Conejo-Garcia *, T. Hasan *, R. Gatenby *, H. Enderling *

author keywords: photomedicine; mathematical oncology; photodynamic therapy; immunotherapy; computational modeling; combination therapy; cancer
TL;DR: The utility of mathematical and computational approaches to guide adaptive therapy, and how mathematical models might be further developed and integrated as a novel methodology to guide precision photomedicine are foreseen. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: April 15, 2019

2019 journal article

Mechanical Characterization of 3D Ovarian Cancer Nodules Using Brillouin Confocal Microscopy

CELLULAR AND MOLECULAR BIOENGINEERING, 12(3), 215–226.

By: C. Conrad*, K. Gray*, K. Stroka *, I. Rizvi n & G. Scarcelli *

author keywords: Tumors; Osmolality; Young's modulus; Stiffness; Spheroids; Optics; Atomic force microscopy; MicroSquisher
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: July 15, 2019

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