Tim Petty

Works (11)

Updated: April 5th, 2024 00:59

2014 article

Modeling oncolytic virotherapy: Is complete tumor-tropism too much of a good thing?

Okamoto, K. W., Amarasekare, P., & Petty, I. T. D. (2014, May 5). Journal of Theoretical Biology.

By: K. Okamoto n, P. Amarasekare * & I. Petty n

author keywords: Oncolytic viruses; Tumor elimination; Apparent competition; Vesicular stomatitis virus
MeSH headings : Humans; Models, Theoretical; Neoplasms / therapy; Oncolytic Virotherapy
topics (OpenAlex): Virus-based gene therapy research; CAR-T cell therapy research; Viral Infectious Diseases and Gene Expression in Insects
TL;DR: Viruses that infect some normal cells can potentially balance the competing goals of tumor elimination and minimizing the effects on normal cell populations, and could improve cancer treatment, with potentially fewer side-effects than conventional treatments such as chemotherapy. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2012 article

Production of prostaglandin E2 in response to infection with modified vaccinia Ankara virus

Pollara, J. J., Spesock, A. H., Pickup, D. J., Laster, S. M., & Petty, I. T. D. (2012, April 23). Virology.

By: J. Pollara n, A. Spesock*, D. Pickup*, S. Laster n & I. Petty n

author keywords: Poxvirus; Vaccine; Lipid mediator; Cyclooxygenase-2; Cytosolic phospholipase A(2); NF-kappa B
MeSH headings : Animals; Arachidonic Acid / metabolism; Cell Line; Cyclooxygenase 2 / genetics; Cyclooxygenase 2 / metabolism; Dinoprostone / metabolism; Humans; Mice; Vaccinia / enzymology; Vaccinia / metabolism; Vaccinia / virology; Vaccinia virus / genetics; Vaccinia virus / physiology; Viral Proteins / genetics; Viral Proteins / metabolism
topics (OpenAlex): Poxvirus research and outbreaks; Immunotherapy and Immune Responses; vaccines and immunoinformatics approaches
TL;DR: In this study, PGE₂ production in vitro by cells infected with the poxvirus vaccine strain, modified vaccinia Ankara virus (MVA), is investigated and it is demonstrated that MVA induced the release of AA from infected cells, and this was, most unusually, independent of host cytosolic phospholipase A₁ activity. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2010 article

Inhibition of poxvirus growth by Terameprocol, a methylated derivative of nordihydroguaiaretic acid

Pollara, J. J., Laster, S. M., & Petty, I. T. D. (2010, October 2). Antiviral Research.

By: J. Pollara*, S. Laster n & I. Petty n

author keywords: Poxvirus; Cowpox virus; Vaccinia virus; Terameprocol; Antiviral agent; Cell-to-cell spread
MeSH headings : Actins / chemistry; Actins / metabolism; Antiviral Agents / pharmacology; Bioterrorism / prevention & control; Cell Line; Clinical Trials, Phase I as Topic; Cowpox virus / drug effects; Cowpox virus / physiology; Humans; Masoprocol / analogs & derivatives; Masoprocol / pharmacology; Poxviridae Infections / drug therapy; Poxviridae Infections / virology; Vaccinia virus / drug effects; Vaccinia virus / physiology; Virus Attachment / drug effects; Virus Replication / drug effects
topics (OpenAlex): Poxvirus research and outbreaks; Herpesvirus Infections and Treatments; Plant Virus Research Studies
TL;DR: The ability of TMP to inhibit poxvirus growth in vitro was examined, and it was found that TMP potently inhibited the growth of both cowpox virus and vaccinia virus in a variety of cell lines. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2009 article

Modified vaccinia virus Ankara can activate NF-κB transcription factors through a double-stranded RNA-activated protein kinase (PKR)-dependent pathway during the early phase of virus replication

Lynch, H. E., Ray, C. A., Oie, K. L., Pollara, J. J., Petty, I. T. D., Sadler, A. J., … Pickup, D. J. (2009, July 12). Virology.

By: H. Lynch*, C. Ray*, K. Oie*, J. Pollara n, I. Petty n, A. Sadler *, B. Williams *, D. Pickup*

author keywords: Vaccinia; MVA; NF-kappaB; I-kappaB; K1L; CP77; Cowpox; PKR; Orthopoxvirus; Vaccine
MeSH headings : Animals; Cell Line; Cricetinae; Humans; I-kappa B Proteins / antagonists & inhibitors; Mice; NF-KappaB Inhibitor alpha; NF-kappa B / biosynthesis; Vaccinia virus / immunology; Vaccinia virus / physiology; Virus Replication; eIF-2 Kinase / immunology
topics (OpenAlex): Poxvirus research and outbreaks; Herpesvirus Infections and Treatments; Virus-based gene therapy research
TL;DR: It is demonstrated that events during the early phase of MVA replication can induce PKR-mediated processes contributing both to the activation of NF-kappaB signaling, and to processes that may restrict viral replication. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2009 article

Terameprocol, a methylated derivative of nordihydroguaiaretic acid, inhibits production of prostaglandins and several key inflammatory cytokines and chemokines

Eads, D., Hansen, R. L., Oyegunwa, A. O., Cecil, C. E., Culver, C. A., Scholle, F., … Laster, S. M. (2009, January 8). Journal of Inflammation, Vol. 6.

By: D. Eads n, R. Hansen n, A. Oyegunwa n, C. Cecil n, C. Culver n, F. Scholle n , I. Petty n, S. Laster n

topics (OpenAlex): Plant-derived Lignans Synthesis and Bioactivity; Peroxisome Proliferator-Activated Receptors; Drug-Induced Hepatotoxicity and Protection
TL;DR: TMP inhibited the LPS-induced production of lipid mediators and several key inflammatory cytokines and chemokines, both in vitro and in vivo, raising the possibility that TMP might be useful as a treatment for a variety of inflammatory disorders. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2001 article

Functional equivalence of late gene promoters in bean golden mosaic virus with those in tomato golden mosaic virus

Hung, H.-C., & Petty, I. T. D. (2001, March 1). Journal of General Virology.

By: H. Hung n & I. Petty n

MeSH headings : DNA, Viral / metabolism; Fabaceae / virology; Geminiviridae / genetics; Gene Expression Regulation, Viral; Genes, Viral; Solanum lycopersicum / virology; Plants, Medicinal; Promoter Regions, Genetic; Transcriptional Activation; Viral Proteins / metabolism
topics (OpenAlex): Plant Virus Research Studies; Legume Nitrogen Fixing Symbiosis; Plant-Microbe Interactions and Immunity
TL;DR: Analysis of the regulation of late gene expression in bean golden mosaic virus (BGMV), one of the begomoviruses which lacks the conserved late element (CLE), found that hybrid viruses with the late gene promoters exchanged between BGMV and TGMV were viable in planta. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2001 article

Genetic Analysis of Bipartite Geminivirus Tissue Tropism

Qin, Y., & Petty, I. T. D. (2001, December 1). Virology.

By: Y. Qin  n & I. Petty n

author keywords: phloem-limited; mesophyll invasion; noncoding region; tomato golden mosaic virus; bean golden mosaic virus; cabbage leaf curl virus
MeSH headings : Adaptation, Physiological; DNA, Viral / metabolism; Fabaceae / virology; Geminiviridae / genetics; Geminiviridae / growth & development; Geminiviridae / pathogenicity; Geminiviridae / physiology; Open Reading Frames; Recombination, Genetic; Tobacco / virology; Tropism / genetics
topics (OpenAlex): Plant Virus Research Studies; Plant-Microbe Interactions and Immunity; Plant and Fungal Interactions Research
TL;DR: It is shown that, in a BGMV-based hybrid virus, CabLCV AL23 also directed efficient mesophyll invasion in conjunction with TGMV BRi, which suggests that host-adaptation of AL23 is important for the phenotype, and is consistent with a model for mesophylli invasion in which AL2 protein acts through the 52-bp region in TGMv BRi to affect expression of the BR1 gene. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2000 article

Bipartite Geminivirus Host Adaptation Determined Cooperatively by Coding and Noncoding Sequences of the Genome

Petty, I. T. D., Carter, S. C., Morra, M. R., Jeffrey, J. L., & Olivey, H. E. (2000, November 1). Virology.

By: I. Petty n, S. Carter n, M. Morra n, J. Jeffrey  n & H. Olivey n

author keywords: geminivirus; host adaptation; noncoding regions; tomato golden mosaic virus; bean golden mosaic virus
MeSH headings : Adaptation, Physiological / genetics; Blotting, Southern; DNA, Plant / genetics; DNA, Viral / analysis; DNA, Viral / genetics; Fabaceae / virology; Geminiviridae / genetics; Geminiviridae / pathogenicity; Genome, Viral; Open Reading Frames; Phenotype; Plants, Medicinal; Plants, Toxic; Species Specificity; Tobacco / virology; Viral Proteins / genetics
topics (OpenAlex): Plant Virus Research Studies; Plant and Fungal Interactions Research; Plant Disease Resistance and Genetics
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2000 article

Tissue Specificity of Geminivirus Infection Is Genetically Determined

Morra, M. R., & Petty, I. T. D. (2000, November 1). The Plant Cell.

By: M. Morra n & I. Petty n

MeSH headings : DNA, Viral; Geminiviridae / genetics; Geminiviridae / physiology; In Situ Hybridization; Plants, Toxic; Tobacco / cytology; Tobacco / virology
topics (OpenAlex): Plant Virus Research Studies; Plant Disease Resistance and Genetics; Plant Molecular Biology Research
TL;DR: This work has demonstrated that three genetic elements of tomato golden mosaic virus determine its mesophyll tissue tropism, the first example documented in a plant virus of noncoding DNA sequences that determine tissue Tropism. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1998 article

Genetic Determinants of Host-Specificity in Bipartite Geminivirus DNA A Components

Gillette, W. K., Meade, T. J., Jeffrey, J. L., & Petty, I. T. D. (1998, November 1). Virology.

By: W. Gillette  n, T. Meade n, J. Jeffrey  n & I. Petty n

MeSH headings : Capsid / metabolism; DNA, Plant / genetics; DNA, Viral / genetics; Fabaceae / virology; Geminiviridae / genetics; Mosaic Viruses / genetics; Open Reading Frames; Phenotype; Plants, Medicinal; Plants, Toxic; Tobacco / genetics
topics (OpenAlex): Plant Virus Research Studies; Plant Disease Resistance and Genetics; Legume Nitrogen Fixing Symbiosis
TL;DR: The contributions of A component ORFs to host adaptation in BGMV and TGMV were investigated and host-adaptation of the AL23 region may have a different mechanistic basis in beans than it does in N. benthamiana. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
Source: Web Of Science
Added: August 6, 2018

1995 article

Complementable and Noncomplementable Host Adaptation Defects in Bipartite Geminiviruses

Petty, I. T. D., Miller, C. G., Meade-Hash, T. J., & Schaffer, R. L. (1995, September 1). Virology.

By: I. Petty n, C. Miller  n, T. Meade-Hash n & R. Schaffer n

MeSH headings : DNA, Viral / genetics; Fabaceae / microbiology; Geminiviridae / genetics; Geminiviridae / growth & development; Genes, Viral; Genetic Complementation Test; Plants, Medicinal; Plants, Toxic; Tobacco; Viral Structural Proteins / genetics; Virus Replication
topics (OpenAlex): Plant Virus Research Studies; Plant and Fungal Interactions Research; Plant Disease Resistance and Genetics
TL;DR: The results of this study indicate that bipartite geminivirus host range may be limited by defective virus-host interactions of more than one kind. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
Source: Web Of Science
Added: August 6, 2018

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