@article{bateni_epps_antami_dargis_bennett_reyes_abolhasani_2022, title={Autonomous Nanocrystal Doping by Self-Driving Fluidic Micro-Processors}, volume={4}, ISSN={["2640-4567"]}, url={https://doi.org/10.1002/aisy.202200017}, DOI={10.1002/aisy.202200017}, abstractNote={Lead halide perovskite (LHP) nanocrystals (NCs) are considered an emerging class of advanced functional materials with numerous outstanding optoelectronic characteristics. Despite their success in the field, their precision synthesis and fundamental mechanistic studies remain a challenge. The vast colloidal synthesis and processing parameters of LHP NCs in combination with the batch-to-batch and lab-to-lab variation problems further complicate their progress. In response, a self-driving fluidic micro-processor is presented for accelerated navigation through the complex synthesis and processing parameter space of NCs with multistage chemistries. The capability of the developed autonomous experimentation strategy is demonstrated for a time-, material-, and labor-efficient search through the sequential halide exchange and cation doping reactions of LHP NCs. Next, a machine learning model of the modular fluidic micro-processors is autonomously built for accelerated fundamental studies of the in-flow metal cation doping of LHP NCs. The surrogate model of the sequential halide exchange and cation doping reactions of LHP NCs is then utilized for five closed-loop synthesis campaigns with different target NC doping levels. The precise and intelligent NC synthesis and processing strategy, presented herein, can be further applied toward the autonomous discovery and development of novel impurity-doped NCs with applications in next-generation energy technologies.}, number={5}, journal={ADVANCED INTELLIGENT SYSTEMS}, publisher={Wiley}, author={Bateni, Fazel and Epps, Robert W. and Antami, Kameel and Dargis, Rokas and Bennett, Jeffery A. and Reyes, Kristofer G. and Abolhasani, Milad}, year={2022}, month={Mar} }
 @article{bennett_abolhasani_2022, title={Autonomous chemical science and engineering enabled by self-driving laboratories}, volume={36}, ISSN={["2211-3398"]}, DOI={10.1016/j.coche.2022.100831}, abstractNote={Recent advances in machine learning (ML) and artificial intelligence have provided an exciting opportunity to computerize the fundamental and applied studies of complex reaction systems via self-driving laboratories. Autonomous robotic experimentation can enable time-, material-, and resource-efficient exploration and/or optimization of high-dimensional space reaction systems. Furthermore, interpretation of the ML models trained on the experimental data can unveil the underlying reaction mechanisms. In this article, we discuss different elements of a self-driving lab, and present recent efforts in autonomous reaction modeling and optimization. Further development and adoption of ML-guided closed-loop experimentation strategies can realize the full potential of autonomous chemical science and engineering to accelerate the discovery and development of advanced materials and molecules.}, journal={CURRENT OPINION IN CHEMICAL ENGINEERING}, author={Bennett, Jeffrey A. and Abolhasani, Milad}, year={2022}, month={Jun} }
 @article{ibrahim_bennett_abolhasani_2022, title={Continuous Room-Temperature Hydrogen Release from Liquid Organic Carriers in a Photocatalytic Packed-Bed Flow Reactor}, volume={5}, ISSN={["1864-564X"]}, url={https://doi.org/10.1002/cssc.202200733}, DOI={10.1002/cssc.202200733}, abstractNote={Despite the potential of hydrogen (H2 ) storage in liquid organic carriers to achieve carbon neutrality, the energy required for H2 release and the cost of catalyst recycling have hindered its large-scale adoption. In response, a photo flow reactor packed with rhodium (Rh)/titania (TiO2 ) photocatalyst was reported for the continuous and selective acceptorless dehydrogenation of 1,2,3,4-tetrahydroquinoline to H2 gas and quinoline under visible light irradiation at room temperature. The tradeoff between the reactor pressure drop and its photocatalytic surface area was resolved by selective in-situ photodeposition of Rh in the photo flow reactor post-packing on the outer surface of the TiO2 microparticles available to photon flux, thereby reducing the optimal Rh loading by 10 times compared to a batch reactor, while facilitating catalyst reuse and regeneration. An example of using quinoline as a hydrogen acceptor to lower the energy of the hydrogen production step was demonstrated via the water-gas shift reaction.}, journal={CHEMSUSCHEM}, publisher={Wiley}, author={Ibrahim, Malek Y. S. and Bennett, Jeffrey A. and Abolhasani, Milad}, year={2022}, month={May} }
 @article{ibrahim_bennett_mason_rodgers_abolhasani_2022, title={Flexible homogeneous hydroformylation: on-demand tuning of aldehyde branching with a cyclic fluorophosphite ligand}, volume={409}, ISSN={["1090-2694"]}, DOI={10.1016/j.jcat.2022.03.030}, abstractNote={• Flexible hydroformylation of olefins using a cyclic monofluorophosphite ligand. • On-demand, in-flow aldehyde regioselectivity tuning from 90% linear to 75% branched. • Hydroformylation of 1-octene with a turnover frequency >75,000 mol ald.mol Rh −1 .h −1. • Selective tuning of the ligand to metal coordination on-the-fly. • In-flow mechanistic studies of rhodium-catalyzed hydroformylation of 1-octene. Tuning aldehyde regioselectivity via homogeneous hydroformylation of olefins using the same catalyst system remains a challenge. Here, we present flexible rhodium (Rh)-catalyzed hydroformylation of 1-octene and propylene with a bulky cyclic monofluorophosphite ligand L . Hydroformylation of 1-octene with Rh/ L catalyst achieves, for the first time , turnover frequencies exceeding 75,000 mol ald.mol Rh −1 .h −1 (at 30% conversion) in segmented flow, while enabling access to an unmatched tunable aldehyde branching (0.06 < linear/branched < 15) with the same ligand L . Our mechanistic studies demonstrate that L provides a viable alternative to traditional bidentate phosphine/phosphite ligands for high activity with the added benefit of tunable selectivity. The unique high flexibility feature of L over traditional linear- or branched-selective ligands allows for on-demand tuning from 90% linear to 75% branched aldehyde in a continuous flow reactor without the need for ligand/catalyst alteration. Furthermore, when starting from the internal olefins, Rh/ L catalyst achieves high regioselectivity (>90%) toward the two positional aldehyde isomers. The high turnover frequencies obtained with L in flow will enhance the economics of the production of aldehydes and their isotopically labeled analogues by significantly reducing the reaction time, thereby enabling better utilization of the increasingly expensive Rh catalyst and minimizing the need for catalyst/ligand separation and recycle.}, journal={JOURNAL OF CATALYSIS}, author={Ibrahim, Malek Y. S. and Bennett, Jeffrey A. and Mason, Dawn and Rodgers, Jody and Abolhasani, Milad}, year={2022}, month={May}, pages={105–117} }
 @misc{volk_campbell_ibrahim_bennett_abolhasani_2022, title={Flow Chemistry: A Sustainable Voyage Through the Chemical Universe en Route to Smart Manufacturing}, volume={13}, ISSN={["1947-5446"]}, DOI={10.1146/annurev-chembioeng-092120-024449}, abstractNote={Microfluidic devices and systems have entered many areas of chemical engineering, and the rate of their adoption is only increasing. As we approach and adapt to the critical global challenges we face in the near future, it is important to consider the capabilities of flow chemistry and its applications in next-generation technologies for sustainability, energy production, and tailor-made specialty chemicals. We present the introduction of microfluidics into the fundamental unit operations of chemical engineering. We discuss the traits and advantages of microfluidic approaches to different reactive systems, both well-established and emerging, with a focus on the integration of modular microfluidic devices into high-efficiency experimental platforms for accelerated process optimization and intensified continuous manufacturing. Finally, we discuss the current state and new horizons in self-driven experimentation in flow chemistry for both intelligent exploration through the chemical universe and distributed manufacturing.}, journal={ANNUAL REVIEW OF CHEMICAL AND BIOMOLECULAR ENGINEERING}, author={Volk, Amanda A. and Campbell, Zachary S. and Ibrahim, Malek Y. S. and Bennett, Jeffrey A. and Abolhasani, Milad}, year={2022}, pages={45–72} }
 @article{davis_bennett_genzer_efimenko_abolhasani_2022, title={Intensified Hydrogenation in Flow Using a Poly(beta-cyclodextrin) Network-Supported Catalyst}, volume={11}, ISSN={["2168-0485"]}, url={https://doi.org/10.1021/acssuschemeng.2c05467}, DOI={10.1021/acssuschemeng.2c05467}, journal={ACS SUSTAINABLE CHEMISTRY & ENGINEERING}, author={Davis, Bradley A. and Bennett, Jeffrey A. and Genzer, Jan and Efimenko, Kirill and Abolhasani, Milad}, year={2022}, month={Nov} }
 @article{bennett_davis_ramezani_genzer_efimenko_abolhasani_2021, title={Continuous Ligand-Free Suzuki-Miyaura Cross-Coupling Reactions in a Cartridge Flow Reactor Using a Gel-Supported Catalyst}, volume={60}, ISSN={["0888-5885"]}, url={https://doi.org/10.1021/acs.iecr.1c01531}, DOI={10.1021/acs.iecr.1c01531}, number={26}, journal={INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH}, publisher={American Chemical Society (ACS)}, author={Bennett, Jeffrey A. and Davis, Bradley A. and Ramezani, Mahdi and Genzer, Jan and Efimenko, Kirill and Abolhasani, Milad}, year={2021}, month={Jul}, pages={9418–9428} }
 @article{bennett_campbell_abolhasani_2019, title={Continuous synthesis of elastomeric macroporous microbeads}, volume={4}, ISSN={["2058-9883"]}, url={https://doi.org/10.1039/C8RE00189H}, DOI={10.1039/c8re00189h}, abstractNote={Macroporous microbeads are synthesized by microfluidic production of silica-loaded polymeric microdroplets followed by porogen removal <italic>via</italic> selective etching.}, number={2}, journal={REACTION CHEMISTRY & ENGINEERING}, publisher={Royal Society of Chemistry (RSC)}, author={Bennett, Jeffrey A. and Campbell, Zachary S. and Abolhasani, Milad}, year={2019}, month={Feb}, pages={254–260} }
 @article{campbell_parker_bennett_yusuf_al-rashdi_lustik_li_abolhasani_2018, title={Continuous Synthesis of Monodisperse Yolk-Shell Titania Microspheres}, volume={30}, ISSN={["1520-5002"]}, url={https://doi.org/10.1021/acs.chemmater.8b04349}, DOI={10.1021/acs.chemmater.8b04349}, abstractNote={A microfluidic strategy is developed for continuous synthesis of monodisperse yolk–shell titania microspheres. The continuous flow synthesis of titania microparticles is achieved by decoupling the microdroplet formation and interfacial hydrolysis reaction steps by utilizing a polar aprotic solvent as the continuous phase in the microreactor. The decoupling of the precursor microdroplet formation and the hydrolysis reaction allows titania synthesis throughputs an order of magnitude higher than those previously reported in a single-channel flow reactor (∼0.1 g/h calcined microparticles), without affecting the microreactor lifetime due to clogging. Flow synthesis and dynamics across a broad range of precursor flow rates are examined, while effects of flow synthesis parameters, including the precursor to continuous phase flow rate ratio, precursor composition, and calcination temperature on the surface morphology, size, and composition of the resulting titania microparticles, are explored in detail. Titania m...}, number={24}, journal={CHEMISTRY OF MATERIALS}, publisher={American Chemical Society (ACS)}, author={Campbell, Zachary S. and Parker, Matthew and Bennett, Jeffrey A. and Yusuf, Seif and Al-Rashdi, Amur K. and Lustik, Jacob and Li, Fanxing and Abolhasani, Milad}, year={2018}, month={Dec}, pages={8948–8958} }