Jennifer Ann Luff

Works (18)

Updated: June 4th, 2024 05:01

2024 article

A putatively novel papillomavirus associated with cutaneous plaques and squamous cell carcinoma in captive North American snow leopards (<i>Panthera uncia</i>)

Womble, M., Weingart, S., May, S., Garner, M., & Luff, J. (2024, May 21). VETERINARY PATHOLOGY.

By: M. Womble n, S. Weingart n, S. May n, M. Garner & J. Luff n

author keywords: Panthera uncia; papillomavirus; snow leopards; squamous cell carcinoma; viral plaques
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: June 3, 2024

2023 journal article

A subset of equine oral squamous cell carcinomas is associated with Equus caballus papillomavirus 2 infection

JOURNAL OF COMPARATIVE PATHOLOGY, 205, 1–6.

By: J. Luff n, S. Weingart n, S. May n & B. Murphy *

author keywords: Equus caballus papillomavirus; horses; in -situ hybridization; oncogenic viruses; oral cavity; squamous cell carcinoma; tongue
TL;DR: This study provides additional support for a pathogenic association of EcPV2 in oral SCC in horses. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: August 28, 2023

2023 article

Claw bed inverted squamous papilloma associated with canine papillomavirus type 2 in a dog

Resendes, A. R., Trainor, K. E., Bera, M., Cheng, R. C. F., & Luff, J. (2023, October 1). VETERINARY DERMATOLOGY.

By: A. Resendes *, K. Trainor, M. Bera, R. Cheng* & J. Luff n

TL;DR: A claw bed inverted squamous papilloma (ISP) presented clinically as a swollen digit in a dog and was demonstrated to be caused by canine papillomavirus type 2. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: October 30, 2023

2022 review

Papillomaviral skin diseases of humans, dogs, cats and horses: A comparative review. Part 1: Papillomavirus biology and hyperplastic lesions

[Review of ]. VETERINARY JOURNAL, 288.

By: J. Munday *, C. Knight* & J. Luff n

author keywords: Hyperplasia; Oncogenic viruses; Papillomas; Treatment; Warts
MeSH headings : Animals; Biology; Carcinoma, Squamous Cell / veterinary; Cat Diseases; Cats; Dog Diseases; Dogs; Horse Diseases; Horses; Humans; Papillomaviridae; Papillomavirus Infections / veterinary; Skin Neoplasms / veterinary
TL;DR: The PV-induced diseases of humans are compared to the similar diseases that develop in the companion animal species by comparing with the human diseases to make assumptions about some of the less common and less well-studied diseases in the veterinary species. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: October 17, 2022

2022 review

Papillomaviral skin diseases of humans, dogs, cats and horses: A comparative review. Part 2: Pre-neoplastic and neoplastic diseases

[Review of ]. VETERINARY JOURNAL, 288.

By: J. Munday *, C. Knight* & J. Luff n

author keywords: Bowenoid in situ carcinoma; Oncogenic viruses; Pigmented plaques; Squamous cell carcinoma; Viral plaques
MeSH headings : Animals; Carcinoma, Squamous Cell / veterinary; Cat Diseases; Cats; DNA, Viral; Dog Diseases; Dogs; Horse Diseases; Horses; Humans; Papillomaviridae / genetics; Skin Neoplasms / veterinary; Virus Diseases / veterinary
TL;DR: A comparative review of the potential use of vaccines to prevent PV-induced diseases of dogs, cats, and horses and the mechanisms by which PVs cause neoplasia is compared. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: October 17, 2022

2021 journal article

Canine Papillomavirus 2 E6 Does Not Interfere With UVB-Induced Upregulation of p53 and p53-Regulated Genes

FRONTIERS IN VETERINARY SCIENCE, 8.

By: S. Quinlan n, S. May n, R. Weeks n, H. Yuan * & J. Luff n

author keywords: canine papillomavirus type 2; E6; p53; LncRNA-p21; bak; bax
TL;DR: It is determined that cutaneousCPV2 E6 does not degrade p53, or interfere with the upregulation of p53-regulated genes p21, Bax, Bak, or lncRNA-p21, suggesting that CPV2 may use a p53 -independent mechanism to contribute to oncogenesis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: March 22, 2021

2021 journal article

HOPX+ injury-resistant intestinal stem cells drive epithelial recovery after severe intestinal ischemia

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 321(5), G588–G602.

By: A. Stewart n , C. Schaaf n, J. Luff n, J. Freund n, T. Becker *, S. Tufts n, J. Robertson n , L. Gonzalez n 

author keywords: epithelial repair; HOPX; ischemia; large animal models; stem cell
MeSH headings : Animals; Cell Proliferation; Disease Models, Animal; Epithelial Cells / metabolism; Epithelial Cells / pathology; Female; Homeodomain Proteins / genetics; Homeodomain Proteins / metabolism; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Male; Mesenteric Ischemia / genetics; Mesenteric Ischemia / metabolism; Mesenteric Ischemia / pathology; Phenotype; Re-Epithelialization; Severity of Illness Index; Stem Cells / metabolism; Stem Cells / pathology; Sus scrofa; Tissue Culture Techniques
TL;DR: It is demonstrated that during early in vivo recovery, injury-resistant HOPX+cells maintain quiescence, suggesting that HopX may serve a functional role in ISC mediated regeneration after injury and could be a target to control ISC proliferation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 3, 2021

2021 journal article

Unlocking the Role of a Genital Herpesvirus, Otarine Herpesvirus 1, in California Sea Lion Cervical Cancer

ANIMALS, 11(2).

By: A. Deming *, J. Wellehan *, K. Colegrove*, A. Hall *, J. Luff n, L. Lowenstine*, P. Duignan *, G. Cortes-Hinojosa *, F. Gulland *

author keywords: California sea lion; cancer; urogenital carcinoma; herpesvirus; oncogenic virus; RNA in situ hybridization; Basescope(&#174)
TL;DR: The hypothesis that OtHV1 plays a significant role in the development of sea lion urogenital carcinoma is supported and there is an underlying trigger or event that causes the virus to induce cancer in some infected sea lions and not others. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (Web of Science; OpenAlex)
Source: Web Of Science
Added: March 15, 2021

2020 journal article

A Subset of Equine Gastric Squamous Cell Carcinomas Is Associated With Equus Caballus Papillomavirus-2 Infection

VETERINARY PATHOLOGY, 57(3), 427–431.

By: E. Alloway n, K. Linder n, S. May n, T. Rose n, J. DeLay*, S. Bender*, A. Tucker*, J. Luff n

author keywords: horses; squamous cell carcinoma; Equus caballus papillomavirus; oncogenic viruses; stomach; in situ hybridization
MeSH headings : Animals; Carcinoma, Squamous Cell / genetics; Carcinoma, Squamous Cell / pathology; Carcinoma, Squamous Cell / veterinary; Carcinoma, Squamous Cell / virology; DNA, Viral / genetics; Horse Diseases / virology; Horses; In Situ Hybridization / veterinary; Oncogenes / genetics; Papillomaviridae / genetics; Papillomaviridae / isolation & purification; Papillomavirus Infections / pathology; Papillomavirus Infections / veterinary; Polymerase Chain Reaction / veterinary; Stomach / pathology; Stomach Neoplasms / veterinary
TL;DR: Support is provided for a potential association between EcPV-2 infection and a subset of equine gastric SCCs by performing polymerase chain reaction (PCR) and in situ hybridization (ISH) for EcPVs E6/ E7 oncogenes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: April 20, 2020

2020 journal article

Abrogation of Constitutive and Induced Type I and Type III Interferons and Interferon-Stimulated Genes in Keratinocytes by Canine Papillomavirus 2 E6 and E7

VIRUSES-BASEL, 12(6).

By: S. Quinlan n, S. May n, R. Weeks n, H. Yuan * & J. Luff n

author keywords: canine; papillomavirus; interferon; interferon-stimulated gene; E6; E7
MeSH headings : Animals; Cell Line; Dogs; Humans; Interferon-beta / metabolism; Keratinocytes / immunology; Keratinocytes / virology; Papillomaviridae / immunology; Papillomavirus E7 Proteins / genetics; Papillomavirus Infections / immunology; Papillomavirus Infections / pathology; Papillomavirus Infections / veterinary; Skin Neoplasms / virology
TL;DR: It is determined that CPV2 E6 and E7 both impact expression of antiviral cytokines in canine keratinocytes, albeit likely through different mechanisms, and that E7 but not E6 abrogates signaling through the type I IFN receptor. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: August 17, 2020

2020 journal article

Unexpected but transient tumour enlargement preceded complete regression and long-term control after irradiation of squamous cell carcinoma in a red-eared slider (Trachemys scripta elegans)

VETERINARY RECORD CASE REPORTS, 8(2).

By: A. Baja n, G. Lewbart n , J. Luff n & M. Nolan n

TL;DR: A red-eared slider with a chronic non-healing ulcerative shell lesion was diagnosed with cutaneous squamous cell carcinoma and underwent surgical debulking and adjuvant hypofractionated radiation therapy, showing an unusual pattern of disease regression, followed by transient growth and then long-term local tumour control. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 8, 2021

2019 journal article

Viral genome integration of canine papillomavirus 16

PAPILLOMAVIRUS RESEARCH, 7, 88–96.

By: J. Luff n, M. Mader n, P. Rowland*, M. Britton*, J. Fass* & H. Yuan *

author keywords: Canine; Papillomavirus; Squamous cell carcinoma; Integration; Carcinogenesis
MeSH headings : Animals; Carcinoma, Squamous Cell / veterinary; Carcinoma, Squamous Cell / virology; DNA, Viral / genetics; Dog Diseases / virology; Dogs; Genome, Viral; Male; Papillomaviridae / genetics; Papillomaviridae / physiology; Papillomavirus Infections / veterinary; Papillomavirus Infections / virology; Sequence Deletion; Skin Neoplasms / veterinary; Skin Neoplasms / virology; Translocation, Genetic; Virus Integration
TL;DR: This is the first description of integration of a canine papillomavirus into the host genome, raising the possibility that CPV16 may be a potential canine high-risk papillumavirus type. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: June 17, 2019

2018 journal article

Cutaneous squamous cell carcinoma associated with Zalophus californianus papillomavirus 1 in a California sea lion

JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, 30(4), 572–575.

By: J. Luff n, R. Burns  n, M. Mader n, K. Priest n & A. Tuttle  n

author keywords: California sea lion; papillomavirus; pigmented viral plaque; squamous cell carcinoma; Zalophus californianus
MeSH headings : Animals; Carcinoma, Squamous Cell / veterinary; Carcinoma, Squamous Cell / virology; DNA Primers; Papillomaviridae / classification; Papillomaviridae / genetics; Papillomaviridae / isolation & purification; Polymerase Chain Reaction / veterinary; Sea Lions; Species Specificity
TL;DR: A case of multiple cutaneous pigmented plaques from a California sea lion that progressed to in situ and invasive squamous cell carcinoma (SCC) is described, using degenerate and specific primers to detect papillomavirus DNA. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Generalized papillomatosis in three horses associated with a novel equine papillomavirus (EcPV8)

Veterinary Dermatology, 29(1).

By: K. Linder, P. Bizikova, J. Luff, D. Zhou, H. Yuan, B. Breuhaus , E. Nelson, R. Mackay

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

Localization of Felis catus Papillomavirus Type 2 E6 and E7 RNA in Feline Cutaneous Squamous Cell Carcinoma

VETERINARY PATHOLOGY, 55(3), 409–416.

By: N. Hoggard  n, J. Munday * & J. Luff n

author keywords: feline; skin; papillomavirus; squamous cell carcinoma; in situ hybridization
MeSH headings : Animals; Carcinoma, Squamous Cell / veterinary; Carcinoma, Squamous Cell / virology; Cat Diseases / pathology; Cat Diseases / virology; Cats; Colorimetry; In Situ Hybridization; Papillomaviridae / classification; Papillomaviridae / genetics; RNA, Messenger / isolation & purification; RNA, Viral / isolation & purification; Reassortant Viruses; Skin Neoplasms / veterinary; Skin Neoplasms / virology
TL;DR: RNAscope in situ hybridization was used to localize FcaPV-2 E6 and E7 transcripts in 18 formalin-fixed paraffin-embedded samples of cutaneous SCC to support a causative role for this papillomavirus in the pathogenesis of feline SCC. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Long-term expansion of primary equine keratinocytes that maintain the ability to differentiate into stratified epidermis

STEM CELL RESEARCH & THERAPY, 9.

By: F. Alkhilaiwi *, L. Wang *, D. Zhou *, T. Raudsepp *, S. Ghosh *, S. Paul*, N. Palechor-Ceron*, S. Brandt * ...

author keywords: Equine primary keratinocytes; Three-dimensional cultures; Skin regeneration; Conditional reprogramming
MeSH headings : Animals; Cell Differentiation / physiology; Cells, Cultured; Epidermal Cells / cytology; Epidermal Cells / metabolism; Epidermis / metabolism; Horses; Keratinocytes / cytology; Keratinocytes / metabolism; Male
TL;DR: The results prove that conditional reprogramming is the first method that allows for the rapid and continued in vitro propagation of primary equine keratinocytes and these unlimited supplies of autologous cells could be used to generate transplants without the risk of immune rejection. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2017 review

Papillomaviruses in dogs and cats

[Review of ]. VETERINARY JOURNAL, 225, 23–31.

By: J. Munday *, N. Thomson * & J. Luff n

author keywords: Papillomavirus; Canine; Feline; Papillomas; Pigmented plaques
MeSH headings : Animals; Bowen's Disease / veterinary; Carcinoma, Basal Cell / veterinary; Carcinoma, Basal Cell / virology; Carcinoma, Squamous Cell / veterinary; Cat Diseases / virology; Cats; Dog Diseases / virology; Dogs; Mouth Neoplasms / veterinary; Mouth Neoplasms / virology; Papilloma / veterinary; Papilloma / virology; Papillomaviridae / classification; Papillomaviridae / genetics; Papillomaviridae / pathogenicity; Papillomavirus Infections / diagnosis; Papillomavirus Infections / prevention & control; Papillomavirus Infections / veterinary; Skin Neoplasms / veterinary; Skin Neoplasms / virology
TL;DR: There is increasing evidence that PVs may also be a cause of cutaneous squamouscell carcinomas and basal cell carcinomas in cats, and Diagnostic techniques and possible methods to prevent PV infection are discussed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Canine keratinocytes upregulate type I interferons and proinflammatory cytokines in response to poly(dA:dT) but not to canine papillomavirus

Veterinary Immunology and Immunopathology, 153(3-4), 177–186.

By: J. Luff*, H. Yuan *, M. Suter*, E. Müller *, R. Schlegel* & P. Moore *

author keywords: Canine papillomavirus; Pattern recognition receptors; Keratinocyte
MeSH headings : Animals; Cells, Cultured; Cytokines / genetics; Dogs; Interferon Type I / genetics; Keratinocytes / drug effects; Keratinocytes / immunology; Papillomaviridae / immunology; Poly dA-dT / pharmacology; RNA, Messenger / analysis; Receptors, Pattern Recognition / genetics; Up-Regulation / drug effects
TL;DR: Results suggest that although canine keratinocytes contain functional PRRs that can recognize and respond to dsDNA and dsRNA ligands, they do not appear to recognize or initiate a similar response to CPV-2. (via Semantic Scholar)
Source: Crossref
Added: February 21, 2020

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