@article{gristina_waldron_nettifee_munana_2023, title={Comparison of caregivers' assessments of clinical outcome in dogs with idiopathic epilepsy administered levetiracetam, zonisamide, or phenobarbital monotherapy}, volume={261}, ISSN={["1943-569X"]}, DOI={10.2460/javma.22.10.0469}, abstractNote={Abstract

OBJECTIVE
To investigate caregivers’ assessments of outcome in dogs with idiopathic epilepsy (IE) administered levetiracetam (LEV), zonisamide (ZNS), or phenobarbital (PB) monotherapy.


ANIMALS
100 dogs with IE administered LEV (n = 34), ZNS (31), or PB (35) monotherapy between January 1, 2003, and February 6, 2019, and survey responses from their caregivers.


PROCEDURES
Information on duration of therapy, adverse effects (AEs), and outcome was obtained from medical record review and caregiver questionnaire.


RESULTS
A significant improvement in mean quality of life score was reported during monotherapy (7.7; SD, 2.14) compared to before treatment (6.25; SD, 2.63; P < .0001), with no difference identified between monotherapy groups. Compared to ZNS monotherapy, dogs prescribed PB monotherapy had a significantly younger median age at seizure onset (2.6 vs 4.3 years; P = .024). A significant relationship was identified between the occurrence of reported AEs and monotherapy group, with a higher prevalence in the PB group (77% [27/35]) and a lower prevalence in the ZNS group (39% [12/31]; P = .0066). Treatment failure rates for PB, LEV, and ZNS monotherapy were 51%, 35%, and 45%, respectively, with failure attributed most commonly to inadequate seizure control. No significant difference was identified between groups with respect to rate of or time to failure.


CLINICAL RELEVANCE
Most caregivers reported a favorable outcome with administration of LEV, ZNS, or PB monotherapy to dogs with IE. Phenobarbital is associated with the highest prevalence of AEs but no difference in quality of life score. Prospective controlled studies are needed to further compare the efficacy and safety of these monotherapies in dogs with IE.
}, number={7}, journal={JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION}, author={Gristina, Bryanna R. and Waldron, Rennie J. and Nettifee, Julie A. and Munana, Karen R.}, year={2023}, month={Jul}, pages={1020–1027} }
 @article{henning_nielson_nettifee_munana_hazel_2021, title={Understanding the impacts of feline epilepsy on cats and their owners}, volume={8}, ISSN={["2042-7670"]}, DOI={10.1002/vetr.836}, abstractNote={AbstractBackgroundEpilepsy is the most common neurological condition reported in cats. Characterised by recurrent seizures, treatment involves the administration of anti‐epileptic drugs up to multiple times a day. Epilepsy and its associated treatments may impact both cats and their owners. The present study aimed to assess factors associated with quality of life (QOL) in cats with epilepsy and the burden of care in their owners.MethodsAn online survey was developed using demographic information and the following validated measures: cat QOL, Zarit burden interview (ZBI) and the cat owner relationship scale (CORS). Regression analysis was conducted using SPSS 26.ResultsResponses were completed by 141 owners from 22 countries. QOL was significantly higher in cats with controlled seizures, no adverse effects from medication and epilepsy onset before 5 years of age. ZBI was significantly lower in owners who felt supported by their veterinarian, who were over 55 and had cats with controlled seizures. Higher CORS was significantly correlated with both higher cat QOL and lower owner ZBI.ConclusionsAdequate seizure control and close cat‐owner relationships may play an important role in mitigating the impact of epilepsy on cats and their owners. Further research into understanding cat‐owner relationships and successfully controlling epilepsy in cats is needed.}, journal={VETERINARY RECORD}, author={Henning, Julia and Nielson, Torben and Nettifee, Julie and Munana, Karen and Hazel, Susan}, year={2021}, month={Aug} }
 @article{muñana_otamendi_nettifee_papich_2018, title={Population pharmacokinetics of extended-release levetiracetam in epileptic dogs when administered alone, with phenobarbital or zonisamide}, volume={32}, ISSN={0891-6640}, url={http://dx.doi.org/10.1111/jvim.15298}, DOI={10.1111/jvim.15298}, abstractNote={BackgroundExtended‐release levetiracetam (LEV‐XR) has gained acceptance as an antiepileptic drug in dogs. No studies have evaluated its disposition in dogs with epilepsy.Hypothesis/ObjectivesTo evaluate the pharmacokinetics of LEV‐XR in epileptic dogs when administered alone or with phenobarbital or zonisamide.AnimalsEighteen client‐owned dogs on steady‐state maintenance treatment with LEV‐XR (Group L, n = 6), LEV‐XR and phenobarbital (Group LP, n = 6), or LEV‐XR and zonisamide (Group LZ, n = 6).MethodsPharmacokinetic study. Blood samples were collected at 0, 2, 4, 8, and 12 hours after LEV‐XR was administered with food. Plasma LEV concentrations were determined by high‐pressure liquid chromatography. A population pharmacokinetic approach and nonlinear mixed effects modeling were used to analyze the data.ResultsTreatment group accounted for most of the interindividual variation. The LP group had lower CMAX (13.38 μg/mL) compared to the L group (33.01 μg/mL) and LZ group (34.13 μg/mL), lower AUC (134.86 versus 352.95 and 452.76 hours·μg/mL, respectively), and higher CL/F (0.17 versus 0.08 and 0.07 L/kg/hr, respectively). The half‐life that defined the terminal slope of the plasma concentration versus time curve (~5 hours) was similar to values previously reported for healthy dogs.Conclusions and Clinical ImportanceConsiderable variation exists in the pharmacokinetics of LEV‐XR in dogs with epilepsy being treated with a common dose regimen. Concurrent administration of phenobarbital contributed significantly to the variation. Other factors evaluated, including co‐administration of zonisamide, were not shown to contribute to the variability. Drug monitoring may be beneficial to determine the most appropriate dose of LEV‐XR in individual dogs.}, number={5}, journal={Journal of Veterinary Internal Medicine}, publisher={Wiley}, author={Muñana, Karen R. and Otamendi, Arturo J. and Nettifee, Julie A. and Papich, Mark G.}, year={2018}, month={Sep}, pages={1677–1683} }
 @article{pastina_early_bergman_nettifee_maller_bray_waldron_castel_munana_papich_et al._2018, title={The pharmacokinetics of cytarabine administered subcutaneously, combined with prednisone, in dogs with meningoencephalomyelitis of unknown etiology}, volume={41}, ISSN={["1365-2885"]}, url={https://doi.org/10.1111/jvp.12667}, DOI={10.1111/jvp.12667}, abstractNote={AbstractThe objective of this study was to describe the pharmacokinetics (PK) of cytarabine (CA) after subcutaneous (SC) administration to dogs with meningoencephalomyelitis of unknown etiology (MUE). Twelve dogs received a single SC dose of CA at 50 mg/m2 as part of treatment of MUE. A sparse sampling technique was used to collect four blood samples from each dog from 0 to 360 min after administration. All dogs were concurrently receiving prednisone (0.5–2 mg kg−1day−1). Plasma CA concentrations were measured by HPLC, and pharmacokinetic parameters were estimated using nonlinear mixed‐effects modeling (NLME). Plasma drug concentrations ranged from 0.05 to 2.8 μg/ml. The population estimate (CV%) for elimination half‐life and Tmax of cytarabine in dogs was 1.09 (21.93) hr and 0.55 (51.03) hr, respectively. The volume of distribution per fraction absorbed was 976.31 (10.85%) ml/kg. Mean plasma concentration of CA for all dogs was above 1.0 μg/ml at the 30‐, 60‐, 90‐, and 120‐min time points. In this study, the pharmacokinetics of CA in dogs with MUE after a single 50 mg/m2 SC injection in dogs was similar to what has been previously reported in healthy beagles; there was moderate variability in the population estimates in this clinical population of dogs.}, number={5}, journal={Journal of Veterinary Pharmacology & Therapeutics}, publisher={Wiley}, author={Pastina, B. and Early, P.J. and Bergman, R.L. and Nettifee, J. and Maller, A. and Bray, K.Y. and Waldron, R.J. and Castel, A.M. and Munana, K.R. and Papich, M.G. and et al.}, year={2018}, month={Oct}, pages={638–643} }
 @inproceedings{nettifee_2014, title={Communications and Long-term Care for the Neurology Patient}, booktitle={ACVIM Interactive Neurology VTS Workshop}, author={Nettifee, J.}, year={2014} }
 @inproceedings{nettifee osborne_2013, title={Exploring Clinical Studies for the Veterinary Technician}, booktitle={North Carolina Veterinary Technician Conference}, author={Nettifee Osborne, J.A.}, year={2013} }
 @inproceedings{nettifee_2009, title={The Technician’s Role in Veterinary Clinical Trials}, booktitle={ACVIM 2009 Montreal: Technician Program}, author={Nettifee, J.A.}, year={2009} }
 @article{nettifee osborne_2008, title={Keppra Seizure Drug Study Service Dog Opens Awareness, Opens Hearts}, journal={CVM Magazine}, author={Nettifee Osborne, J.A.}, year={2008} }
 @article{flammer_nettifee osborne_webb_foster_dillard_davis_2008, title={Pharmacokinetics of voriconazole after oral administration of single and multiple doses in African grey parrots (Psittacus erithacus timneh)}, volume={69}, ISSN={0002-9645}, url={http://dx.doi.org/10.2460/ajvr.69.1.114}, DOI={10.2460/ajvr.69.1.114}, abstractNote={Abstract
Objective—To determine the pharmacokinetics and safety of orally administered voriconazole in African grey parrots.
Animals—20 clinically normal Timneh African grey parrots (Psittacus erithacus timneh).
Procedures—In single-dose trials, 12 parrots were each administered 6, 12, and 18 mg of voriconazole/kg orally and plasma concentrations of voriconazole were determined via high-pressure liquid chromatography. In a multiple-dose trial, voriconazole (18 mg/kg) was administered orally to 6 birds every 12 hours for 9 days; a control group (2 birds) received tap water. Treatment effects were assessed via observation, clinicopathologic analyses (3 assessments), and measurement of trough plasma voriconazole concentrations (2 assessments).
Results—Voriconazole's elimination half-life was short (1.1 to 1.6 hours). Higher doses resulted in disproportional increases in the maximum plasma voriconazole concentration and area under the curve. Trough plasma voriconazole concentrations achieved in the multiple-dose trial were lower than those achieved after administration of single doses. Polyuria (the only adverse treatment effect) developed in treated and control birds but was more severe in the treatment group.
Conclusions and Clinical Relevance—In African grey parrots, voriconazole has dose-dependent pharmacokinetics and may induce its own metabolism. Oral administration of 12 to 18 mg of voriconazole/kg twice daily is a rational starting dose for treatment of African grey parrots infected with Aspergillus or other fungal organisms that have a minimal inhibitory concentration for voriconazole ≤ 0.4 μg/mL. Higher doses may be needed to maintain plasma voriconazole concentrations during long-term treatment. Safety and efficacy of various voriconazole treatment regimens in this species require investigation.}, number={1}, journal={American Journal of Veterinary Research}, publisher={American Veterinary Medical Association (AVMA)}, author={Flammer, Keven and Nettifee Osborne, Julie A. and Webb, Donna J. and Foster, Laura E. and Dillard, Stacy L. and Davis, Jennifer L.}, year={2008}, month={Jan}, pages={114–121} }
 @inproceedings{nettifee_2008, title={Technician Case Report}, booktitle={ACVIM 2008}, author={Nettifee, J.A.}, year={2008} }
 @inproceedings{nettifee_2008, title={The Technician’s Role in Veterinary Clinical Trials}, booktitle={North Carolina Veterinary Conference 2008}, author={Nettifee, J.A.}, year={2008} }
 @article{williams_nettifee-osborne_johnson_2006, title={A Model for Improving Student Confidence and Experience in Diagnostic Sample Collection and Interpretation}, volume={33}, ISSN={0748-321X 1943-7218}, url={http://dx.doi.org/10.3138/jvme.33.1.132}, DOI={10.3138/jvme.33.1.132}, abstractNote={Confidence and proficiency in diagnosing and treating a variety of diseases is of obvious importance to veterinary students. Traditional teaching methods relying on live-animal laboratories or teaching-hospital cases may not provide the breadth and depth of experience necessary to promote optimal development of confidence and skills. These settings also raise concerns about expense, about animal welfare when animals are used in teaching laboratories, and about the stress and potential risks associated with client-owned pets in the teaching hospital. A one-week course implemented in our veterinary curriculum provides the opportunity for students to develop self-assurance and experience in sample collection and interpretation skills in a realistic, clinical-model setting. This course provides students with significantly improved levels of confidence when performing procedures and interpreting results from a variety of procedures and helps prepare them to become clinicians entering the practice of veterinary medicine.}, number={1}, journal={Journal of Veterinary Medical Education}, publisher={University of Toronto Press Inc. (UTPress)}, author={Williams, Laurel E. and Nettifee-Osborne, Julie A. and Johnson, Jeffrey L.}, year={2006}, month={Mar}, pages={132–139} }
 @article{degernes_nettifee osborne_2006, title={A Model for Teaching Raptor Medicine in the Veterinary Curriculum}, volume={33}, ISSN={0748-321X 1943-7218}, url={http://dx.doi.org/10.3138/jvme.33.3.365}, DOI={10.3138/jvme.33.3.365}, abstractNote={ Injured or sick wild avian species, especially raptors (birds of prey, including hawks, owls, falcons, and eagles), can present different challenges to veterinary students and veterinarians who are trained in companion avian medicine (e.g., parrot medicine). Proper capture and restraint, feeding, housing, and certain diagnostic and treatment techniques involving raptors require different skills, knowledge, and resources than working with parrots. We developed an innovative raptor medicine program that enables students to acquire proficiency in safe capture, restraint, and examination techniques and in common diagnostic and treatment procedures. A self-assessment survey was developed to determine students’ confidence and proficiency in 10 procedures taught in the lab. Groups were compared by class status (Year 1 vs. Year 2 and 3) and level of prior raptor experience (non-experienced or experienced). In surveys conducted before and after teaching two sets of raptor training labs, students rated themselves significantly more proficient in all 10 diagnostic and treatment procedures after completing the two raptor laboratories. The greatest improvements were observed in technical skill procedures such as fluid administration, intramuscular injections, cloacal swabs, venipuncture, and bandaging. Our approach to incorporating elective wildlife learning experiences into the veterinary curriculum may be replicable in other veterinary schools, with or without a wildlife rehabilitation program. }, number={3}, journal={Journal of Veterinary Medical Education}, publisher={University of Toronto Press Inc. (UTPress)}, author={Degernes, Laurel A. and Nettifee Osborne, Julie A.}, year={2006}, month={Sep}, pages={365–372} }
 @article{munana_nettifee osborne_2006, title={Genetics and Canine Seizures-Building Links to Greater Knowledge, Treatments}, journal={Collie Expressions}, author={Munana, K. and Nettifee Osborne, J.A.}, year={2006}, month={Jul}, pages={40–41} }
 @article{nettifee osborne_2000, title={Seizing Control of the Situation: A Guide to Treating Seizures in Companion Animals}, volume={21}, number={3}, journal={Veterinary Technician Magazine}, author={Nettifee Osborne, J.A.}, year={2000}, pages={134–139} }
 @article{nettifee osborne_2000, title={Seizing Control of the Situation: A Guide to Treating Seizures in Companion Animals}, volume={21}, number={3}, journal={Veterinary Technician}, author={Nettifee Osborne, J.A.}, year={2000}, month={Mar}, pages={134–139} }
 @article{nettifee osborne_sharp_1998, title={Putting ‘Wobblers’ Back on Track — Part 1}, volume={19}, number={7}, journal={Veterinary Technician}, author={Nettifee Osborne, J.A. and Sharp, Nicholas J.H.}, year={1998}, month={Jul}, pages={449–459, 485} }
 @article{nettifee osborne_sharp_1998, title={Putting ‘Wobblers’ Back on Track — Part II}, volume={19}, number={8}, journal={Veterinary Technician}, author={Nettifee Osborne, J.A. and Sharp, Nicholas J.H.}, year={1998}, pages={519–527} }
 @article{nettifee osborne_1998, title={The Power of One}, journal={CVM Magazine}, author={Nettifee Osborne, J.A.}, year={1998} }
 @inproceedings{nettifee osborne_1997, title={Schering Plough Animal Health}, booktitle={First International British Veterinary Nursing Congress}, author={Nettifee Osborne, J.A.}, year={1997} }
 @article{nettifee osborne_1997, title={The Road to Recovery: Rehabilitation Following Neurosurgery}, volume={18}, number={7}, journal={Veterinary Technician}, author={Nettifee Osborne, J.A.}, year={1997}, month={Jul}, pages={500–503, 507–509, 517} }
 @article{nettifee osborne_1994, title={Perspectives: Public Relations for Veterinary Technology}, volume={15}, number={5}, journal={Veterinary Technician}, author={Nettifee Osborne, J.A.}, year={1994}, month={May}, pages={253, 265} }
 @article{nettifee osborne_1994, title={Perspectives: Reinventing the Wheel — Human Nursing and Veterinary Technology}, volume={15}, number={9}, journal={Veterinary Technician}, author={Nettifee Osborne, J.A.}, year={1994}, month={Sep}, pages={500–502} }
 @article{nettifee_1992, title={Canine Heartworm Antigen Testing: Current Concepts in Selecting a Screening Program}, volume={13}, number={10}, journal={Veterinary Technician}, author={Nettifee, J.A.}, year={1992}, pages={674–677} }
 @article{nettifee osborne_1992, title={Canine Heartworm Antigen Testing: Current Concepts in Selecting a Screening Program,}, volume={13}, journal={Veterinary Technician}, author={Nettifee Osborne, J.A.}, year={1992}, pages={674–675} }
 @article{nettifee_1991, title={Biotechnology and Feline Leukemia Virus Testing: The Advance of Diagnostics in the 1990s}, volume={12}, number={9}, journal={Veterinary Technician}, author={Nettifee, J.A.}, year={1991}, month={Oct}, pages={654–656} }
 @article{nettifee_1990, title={A Battle for Survival}, journal={Dutchess Magazine}, author={Nettifee, J.A.}, year={1990}, month={Aug}, pages={32–41} }
 @article{nettifee_1989, title={The Technician’s Role in the Prevention, Control, and Management of Large Animal Toxicoses}, volume={10}, number={6}, journal={Veterinary Technician}, author={Nettifee, J.A.}, year={1989}, month={Jul}, pages={405–413, 426} }
 @article{nettifee_1987, title={The Role of the Technician in Poison Control and Treatment}, volume={8}, number={10}, journal={Veterinary Technician}, author={Nettifee, J.A.}, year={1987}, month={Nov}, pages={481–486} }