Jorge Piedrahita Schaaf, C. R., Polkoff, K. M., Carter, A., Stewart, A. S., Sheahan, B., Freund, J., … Gonzalez, L. M. (2023). A LGR5 reporter pig model closely resembles human intestine for improved study of stem cells in disease. FASEB JOURNAL, 37(6). https://doi.org/10.1096/fj.202300223R Zhang, W., Wang, X., Lanzoni, G., Wauthier, E., Simpson, S., Ezzell, J. A., … Reid, L. M. A. (2023). A postnatal network of co-hepato/pancreatic stem/progenitors in the biliary trees of pigs and humans. NPJ REGENERATIVE MEDICINE, 8(1). https://doi.org/10.1038/s41536-023-00303-5 Liu, B., Paudel, S., Flowers, W. L., Piedrahita, J. A., & Wang, X. (2023, May). Adrenomedullin Stimulates Proliferation, Migration and Adhesion of Porcine Trophectoderm Cells Via CALCRL-AKT-TSC2-MTORC1 Cell Signaling Pathway. JOURNAL OF ANIMAL SCIENCE, Vol. 101. https://doi.org/10.1093/jas/skad068.040 Gonzalez, T. J., Mitchell-Dick, A., Blondel, L. O., Fanous, M. M., Hull, J. A., Oh, D. K., … Asokan, A. (2023, September 21). Structure-guided AAV capsid evolution strategies for enhanced CNS gene delivery. NATURE PROTOCOLS. https://doi.org/10.1038/s41596-023-00875-y Liu, B., Paudel, S., Flowers, W. L., Piedrahita, J. A., & Wang, X. (2023, April 10). Uterine histotroph and conceptus development: III. Adrenomedullin stimulates proliferation, migration and adhesion of porcine trophectoderm cells via AKT-TSC2-MTOR cell signaling pathway. AMINO ACIDS, Vol. 4. https://doi.org/10.1007/s00726-023-03265-6 Howe, D., Cone, S. G., Piedrahita, J. A., Spang, J. T., & Fisher, M. B. (2022). Age- and Sex-Specific Joint Biomechanics in Response to Partial and Complete Anterior Cruciate Ligament Injury in the Porcine Model. JOURNAL OF ATHLETIC TRAINING, 57(9-10), 978–989. https://doi.org/10.4085/1062-6050-565-21 Sper, R. B., Proctor, J., Lascina, O., Guo, L., Polkoff, K., Kaeser, T., … Piedrahita, J. A. (2022). Allogeneic and xenogeneic lymphoid reconstitution in a RAG2(-/-)IL2RG(y/-) severe combined immunodeficient pig: A preclinical model for intrauterine hematopoietic transplantation. FRONTIERS IN VETERINARY SCIENCE, 9. https://doi.org/10.3389/fvets.2022.965316 Gonzalez, T. J., Simon, K. E., Blondel, L. O., Fanous, M. M., Roger, A. L., Maysonet, M. S., … Asokan, A. (2022). Cross-species evolution of a highly potent AAV variant for therapeutic gene transfer and genome editing. NATURE COMMUNICATIONS, 13(1). https://doi.org/10.1038/s41467-022-33745-4 Detwiler, A., Polkoff, K., Gaffney, L., Freytes, D. O., & Piedrahita, J. A. (2022, August 4). Donor Age and Time in Culture Affect Dermal Fibroblast Contraction in an In Vitro Hydrogel Model. TISSUE ENGINEERING PART A. https://doi.org/10.1089/ten.tea.2021.0217 Polkoff, K. M., Gupta, N. K., Green, A. J., Murphy, Y., Chung, J., Gleason, K. L., … Piedrahita, J. A. (2022). LGR5 is a conserved marker of hair follicle stem cells in multiple species and is present early and throughout follicle morphogenesis. SCIENTIFIC REPORTS, 12(1). https://doi.org/10.1038/s41598-022-13056-w Chansoria, P., Asif, S., Gupta, N., Piedrahita, J., & Shirwaiker, R. A. (2022, January 27). Multiscale Anisotropic Tissue Biofabrication via Bulk Acoustic Patterning of Cells and Functional Additives in Hybrid Bioinks. ADVANCED HEALTHCARE MATERIALS, Vol. 1. https://doi.org/10.1002/adhm.202102351 Moatti, A., Li, C., Sivadanam, S., Cai, Y., Ranta, J., Piedrahita, J. A., … Greenbaum, A. (2022). Ontogeny of cellular organization and LGR5 expression in porcine cochlea revealed using tissue clearing and 3D imaging. ISCIENCE, 25(8). https://doi.org/10.1016/j.isci.2022.104695 Vaden, S. L., Mathews, K. G., Yoo, J., Williams, J. K., Harris, T., Secoura, P., … Piedrahita, J. (2022, August 5). The use of autologous skeletal muscle progenitor cells for adjunctive treatment of presumptive urethral sphincter mechanism incompetence in female dogs. JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 8. https://doi.org/10.1111/jvim.16505 Chansoria, P., Asif, S., Polkoff, K., Chung, J., Piedrahita, J. A., & Shirwaiker, R. A. (2021). Characterizing the Effects of Synergistic Thermal and Photo-Cross-Linking during Biofabrication on the Structural and Functional Properties of Gelatin Methacryloyl (GeIMA) Hydrogels. ACS BIOMATERIALS SCIENCE & ENGINEERING, 7(11), 5175–5188. https://doi.org/10.1021/acsbiomaterials.1c00635 Zhang, W., Lanzoni, G., Hani, H., Overi, D., Cardinale, V., Simpson, S., … Reid, L. M. (2021). Patch grafting, strategies for transplantation of organoids into solid organs such as liver. BIOMATERIALS, 277. https://doi.org/10.1016/j.biomaterials.2021.121067 Howe, D., Cone, S. G., Piedrahita, J. A., Collins, B., Fordham, L. A., Griffith, E. H., … Fisher, M. B. (2021, November 9). Sex-specific biomechanics and morphology of the anterior cruciate ligament during skeletal growth in a porcine model. JOURNAL OF ORTHOPAEDIC RESEARCH. https://doi.org/10.1002/jor.25207 Platt, J. L., Piedrahita, J. A., & Cascalho, M. (2020, August). Clinical xenotransplantation of the heart: At the watershed. JOURNAL OF HEART AND LUNG TRANSPLANTATION, Vol. 39, pp. 758–760. https://doi.org/10.1016/j.healun.2020.06.002 Polkoff, K. M., Chung, J., Simpson, S. G., Gleason, K., & Piedrahita, J. A. (2020). In Vitro Validation of Transgene Expression in Gene-Edited Pias Using CRISPR Transcriptional Activators. CRISPR JOURNAL, 3(5), 409–418. https://doi.org/10.1089/crispr.2020.0037 Cone, S. G., Lambeth, E. P., Piedrahita, J. A., Spang, J. T., & Fisher, M. B. (2020). Joint laxity varies in response to partial and complete anterior cruciate ligament injuries throughout skeletal growth. JOURNAL OF BIOMECHANICS, 101. https://doi.org/10.1016/j.jbiomech.2020.109636 Moatti, A., Cai, Y., Li, C., Sattler, T., Edwards, L., Piedrahita, J., … Greenbaum, A. (2020). Three-dimensional imaging of intact porcine cochlea using tissue clearing and custom-built light-sheet microscopy. BIOMEDICAL OPTICS EXPRESS, 11(11), 6181–6196. https://doi.org/10.1364/BOE.402991 Gupta, N., Polkoff, K., Qiao, L., Cheng, K., & Piedrahita, J. (2019). 200 Developing exosomes as a mediator for CRISPR/Cas-9 delivery. Reproduction, Fertility and Development, 31(1), 225. https://doi.org/10.1071/RDV31N1AB200 Cone, S. G., Lambeth, E. P., Ru, H., Fordham, L. A., Piedrahita, J. A., Spang, J. T., & Fisher, M. B. (2019). Biomechanical Function and Size of the Anteromedial and Posterolateral Bundles of the ACL Change Differently with Skeletal Growth in the Pig Model. CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 477(9), 2161–2174. https://doi.org/10.1097/CORR.0000000000000884 Cone, S. G., Piedrahita, J. A., Spang, J. T., & Fisher, M. B. (2019). In Situ Joint Stiffness Increases During Skeletal Growth but Decreases Following Partial and Complete Anterior Cruciate Ligament Injury. JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 141(12). https://doi.org/10.1115/1.4044582 Cone, S. G., Piercy, H. E., Lambeth, E. P., Ru, H., Piedrahita, J. A., Spang, J. T., … Fisher, M. B. (2019). Tissue-specific changes in size and shape of the ligaments and tendons of the porcine knee during post-natal growth. PLOS ONE, 14(10). https://doi.org/10.1371/journal.pone.0219637 Chung, J., Zhang, X., Collins, B., Sper, R. B., Gleason, K., Simpson, S., … Piedrahita, J. A. (2018). High mobility group A2 (HMGA2) deficiency in pigs leads to dwarfism, abnormal fetal resource allocation, and cryptorchidism. Proceedings of the National Academy of Sciences, 115(21), 5420–5425. https://doi.org/10.1073/pnas.1721630115 Jungersen, G., & Piedrahita, J. (2018). INTRODUCTION: Immune Relevant Animal Models: Opportunities and Challenges. ILAR JOURNAL, Vol. 59, pp. 209–210. https://doi.org/10.1093/ilar/ilz014 Platt, J. L., Cascalho, M., & Piedrahita, J. A. (2018). [Review of Xenotransplantation: Progress Along Paths Uncertain from Models to Application]. ILAR JOURNAL, 59(3), 286–308. https://doi.org/10.1093/ilar/ily015 Piedrahita, J. A., & Williams, J. K. (2017). Animal Models in Tissue Engineering. Part I. Tissue Engineering Part C: Methods, 23(11), 641–642. https://doi.org/10.1089/ten.tec.2017.0402 Piedrahita, J. A., & Williams, J. K. (2017). Animal Models in Tissue Engineering. Part II. Tissue Engineering Part C: Methods, 23(12), 827–828. https://doi.org/10.1089/ten.TEC.2017.0458 Gonçalves, N. J. N., Bressan, F. F., Roballo, K. C. S., Meirelles, F. V., Xavier, P. L. P., Fukumasu, H., … Ambrósio, C. E. (2017). Generation of LIF-independent induced pluripotent stem cells from canine fetal fibroblasts. Theriogenology, 92, 75–82. https://doi.org/10.1016/j.theriogenology.2017.01.013 Sper, R. B., Koh, S., Zhang, X., Simpson, S., Collins, B., Sommer, J., … Piedrahita, J. A. (2017). Generation of a Stable Transgenic Swine Model Expressing a Porcine Histone 2B-eGFP Fusion Protein for Cell Tracking and Chromosome Dynamics Studies. PLOS ONE, 12(1), e0169242. https://doi.org/10.1371/journal.pone.0169242 Koh, S., Purser, M., Wysk, R., & Piedrahita, J. A. (2017). Improved Chondrogenic Potential and Proteomic Phenotype of Porcine Chondrocytes Grown in Optimized Culture Conditions. Cellular Reprogramming, 19(4), 232–244. https://doi.org/10.1089/cell.2017.0005 Cone, S. G., Simpson, S. G., Piedrahita, J. A., Fordham, L. A., Spang, J. T., & Fisher, M. B. (2017). Orientation changes in the cruciate ligaments of the knee during skeletal growth: A porcine model. Journal of Orthopaedic Research, 35(12), 2725–2732. https://doi.org/10.1002/jor.23594 Sper, R., Simpson, S., Zhang, X., Collins, B., & Piedrahita, J. (2016). 1 GENERATION OF A STABLE TRANSGENIC SWINE MODEL FOR CELL TRACKING AND CHROMOSOME DYNAMIC STUDIES. Reproduction, Fertility and Development, 28(2), 130. https://doi.org/10.1071/RDV28N2AB1 Simpson, S., Gonzalez, L., Chung, J., Blikslager, A., Magness, S., & Piedrahita, J. (2016). 27 AN IMPROVED LARGE ANIMAL MODEL FOR THE STUDY OF ADULT STEM CELLS. Reproduction, Fertility and Development, 28(2), 143. https://doi.org/10.1071/RDV28N2AB27 Jeong, K. Y., Nelson, P. V., Niedziela, C. E., Jr., & Dickey, D. A. (2016). Effect of Plant Species, Fertilizer Acidity/Basicity, and Fertilizer Concentration on pH of Soilless Root Substrate. HORTSCIENCE, 51(12), 1596–1601. https://doi.org/10.21273/hortsci11237-16 Hensley, M. T., Andrade, J., Keene, B., Meurs, K., Tang, J. N., Wang, Z. G., … al. (2015). Cardiac regenerative potential of cardiosphere-derived cells from adult dog hearts. Journal of Cellular and Molecular Medicine, 19(8), 1805–1813. https://doi.org/10.1111/jcmm.12585 Oliveira, V. C., Mançanares, C. A. F., Oliveira, L. J., Gonçalves, N. J. N., Miglino, M. A., Perecin, F., … Ambrósio, C. E. (2015). Characterization of putative haematopoietic cells from bovine yolk sac. Journal of Tissue Engineering and Regenerative Medicine, 11(4), 1132–1140. https://doi.org/10.1002/TERM.2016 Koh, S., & Piedrahita, J. A. (2015). Generation of Induced Pluripotent Stem Cells (iPSCs) from Adult Canine Fibroblasts. In Methods in Molecular Biology (pp. 69–78). https://doi.org/10.1007/978-1-4939-2848-4_7 Vandergriff, A. C., de Andrade, J. B. M., Tang, J., Hensley, M. T., Piedrahita, J. A., Caranasos, T. G., & Cheng, K. (2015). Intravenous Cardiac Stem Cell-Derived Exosomes Ameliorate Cardiac Dysfunction in Doxorubicin Induced Dilated Cardiomyopathy. Stem Cells International, 2015, 1–8. https://doi.org/10.1155/2015/960926 Chung, J., Zhang, X., Colins, B., Howard, K., Simpson, S., Salmon, C., … Piedrahita, J. (2014). 5 DISRUPTION OF THE HIGH MOBILITY GROUP AT-HOOK 2 (HMGA2) GENE IN SWINE REDUCES POSTNATAL GROWTH. Reproduction, Fertility and Development, 26(1), 117. https://doi.org/10.1071/RDV26N1AB5 Koh, S., & Piedrahita, J. A. (2014). [Review of From "ES-like" cells to induced pluripotent stem cells: A historical perspective in domestic animals]. THERIOGENOLOGY, 81(1), 103–111. https://doi.org/10.1016/j.theriogenology.2013.09.009 Gonçalves, N. N., Ambrósio, C. E., & Piedrahita, J. A. (2014). Stem Cells and Regenerative Medicine in Domestic and Companion Animals: A Multispecies Perspective. Reproduction in Domestic Animals, 49, 2–10. https://doi.org/10.1111/rda.12392 Lim, J.-H., McCullen, S. D., Piedrahita, J. A., Loboa, E. G., & Olby, N. J. (2013). Alternating Current Electric Fields of Varying Frequencies: Effects on Proliferation and Differentiation of Porcine Neural Progenitor Cells. Cellular Reprogramming, 15(5), 405–412. https://doi.org/10.1089/cell.2013.0001 Gonzalez, L. M., Williamson, I., Piedrahita, J. A., Blikslager, A. T., & Magness, S. T. (2013). Cell lineage identification and stem cell culture in a porcine model for the study of intestinal epithelial regeneration. PLoS One, 8(6). Bischoff, S. R., Tsai, S. Q., Hardison, N. E., Motsinger-Reif, A. A., Freking, B. A., Nonneman, D. J., … Piedrahita, J. A. (2013). Differences in X-Chromosome Transcriptional Activity and Cholesterol Metabolism between Placentae from Swine Breeds from Asian and Western Origins. PLOS ONE, 8(1). https://doi.org/10.1371/journal.pone.0055345 Guo, L., Tsai, S. Q., Hardison, N. E., James, A. H., Motsinger-Reif, A. A., Thames, B., … Piedrahita, J. A. (2013). Differentially expressed microRNAs and affected biological pathways revealed by modulated modularity clustering (MMC) analysis of human preeclamptic and IUGR placentas. Placenta, 34(7), 599–605. https://doi.org/10.1016/j.placenta.2013.04.007 Farmer, W. T., Farin, P. W., Piedrahita, J. A., Bischoff, S. R., & Farin, C. E. (2013). Expression of antisense of insulin-like growth factor-2 receptor RNA non-coding (AIRN) during early gestation in cattle. Animal Reproduction Science, 138(1-2), 64–73. https://doi.org/10.1016/J.ANIREPROSCI.2013.01.009 Koh, S., Thomas, R., Tsai, S., Bischoff, S., Lim, J.-H., Breen, M., … Piedrahita, J. A. (2013). Growth Requirements and Chromosomal Instability of Induced Pluripotent Stem Cells Generated from Adult Canine Fibroblasts. Stem Cells and Development, 22(6), 951–963. https://doi.org/10.1089/scd.2012.0393 Gonzalez, L., Blikslager, A., Piedrahita, J. A., & Magness, S. T. (2013). Su1099 A Translational Porcine Model of Intestinal Stem Cells. Gastroenterology, 144(5), S-398. https://doi.org/10.1016/S0016-5085(13)61466-3 Piedrahita, J. A., Koh, S., & Olby, N. (2012). GENERATION AND CHARACTERISATION OF INDUCED PLURIPOTENT STEM CELLS (iPSCs) FROM ADULT CANINE FIBROBLASTS. Reproduction, Fertility and Development, 24(1), 285. https://doi.org/10.1071/RDv24n1Ab244 Koh, S., Tsai, S., Bischoff, S., Thomas, R., Lim, J. H., Breen, M., … Piedrahita, J. (2012). Generation and characterization of induced pluripotent stem cells (iPS) from adult canine fibroblasts. Reproduction in Domestic Animals, 47, 418–419. Lim, J.-H., Koh, S., Olby, N. J., Piedrahita, J., & Mariani, C. L. (2012). Isolation and characterization of neural progenitor cells from adult canine brains. American Journal of Veterinary Research, 73(12), 1963–1968. https://doi.org/10.2460/ajvr.73.12.1963 Chung, J., Tsai, S., James, A. H., Thames, B. H., Shytle, S., & Piedrahita, J. A. (2012). Lack of genomic imprinting of DNA primase, polypeptide 2 (PRIM2) in human term placenta and white blood cells. EPIGENETICS, 7(5), 429–431. https://doi.org/10.4161/epi.19777 Sommer, J. R., Jackson, L. R., Simpson, S. G., Collins, E. B., Piedrahita, J. A., & Petters, R. M. (2012). Transgenic Stra8-EYFP pigs: a model for developing male germ cell technologies. TRANSGENIC RESEARCH, 21(2), 383–392. https://doi.org/10.1007/s11248-011-9542-6 Sommer, J. R., Jackson, L., Simpson, S., Collins, E. B., Piedrahita, J., & Petters, R. M. (2011). 336 TRANSGENIC Stra8-EYFP PIGS: A MODEL FOR DEVELOPING MALE GERM CELL TECHNOLOGIES. Reproduction, Fertility and Development, 23(1), 264. https://doi.org/10.1071/RDv23n1Ab336 Piedrahita, J. A., & Olby, N. (2011). Perspectives on transgenic livestock in agriculture and biomedicine: An update. Reproduction, Fertility and Development, 23(1), 56–63. Piedrahita, J. A., & Olby, N. (2011). Perspectives on transgenic livestock in agriculture and biomedicine: an update. Reproduction, Fertility and Development, 23(1), 56. https://doi.org/10.1071/RD10246 Sommer, J. R., Estrada, J. L., Collins, E. B., Bedell, M., Alexander, C. A., Yang, Z., … Zhang, K. (2011). Production of ELOVL4 transgenic pigs: a large animal model for Stargardt-like macular degeneration. British Journal of Ophthalmology, 95(12), 1749–1754. https://doi.org/10.1136/bjophthalmol-2011-300417 Piedrahita, J. A. (2011). [Review of The Role of Imprinted Genes in Fetal Growth Abnormalities]. BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY, 91(8), 682–692. https://doi.org/10.1002/bdra.20795 Tsai, S., Hardison, N. E., James, A. H., Motsinger-Reif, A. A., Bischoff, S. R., Thames, B. H., & Piedrahita, J. A. (2011). Transcriptional profiling of human placentas from pregnancies complicated by preeclampsia reveals disregulation of sialic acid acetylesterase and immune signalling pathways. PLACENTA, 32(2), 175–182. https://doi.org/10.1016/j.placenta.2010.11.014 Lim, J.-H., Piedrahita, J. A., Jackson, L., Ghashghaei, T., & Olby, N. J. (2010). Development of a Model of Sacrocaudal Spinal Cord Injury in Cloned Yucatan MiniPigs for Cellular Transplantation Research. CELLULAR REPROGRAMMING, 12(6), 689–697. https://doi.org/10.1089/cell.2010.0039 Lim, J.-H., Boozer, L., Mariani, C. L., Piedrahita, J. A., & Olby, N. J. (2010). Generation and Characterization of Neurospheres from Canine Adipose Tissue-Derived Stromal Cells. CELLULAR REPROGRAMMING, 12(4), 417–425. https://doi.org/10.1089/cell.2009.0093 McCalla-Martin, A. C., Chen, X., Linder, K. E., Estrada, J. L., & Piedrahita, J. A. (2010). Varying phenotypes in swine versus murine transgenic models constitutively expressing the same human Sonic hedgehog transcriptional activator, K5-HGLI2ΔN. Transgenic Research, 19(5), 869–887. https://doi.org/10.1007/s11248-010-9362-0 Bischoff, S. R., Tsai, S., Hardison, N., Motsinger-Reif, A. A., Freking, B. A., Nonneman, D., … Piedrahita, J. A. (2009). Characterization of Conserved and Nonconserved Imprinted Genes in Swine. BIOLOGY OF REPRODUCTION, 81(5), 906–920. https://doi.org/10.1095/biolreprod.109.078139 Caballero, I., & Piedrahita, J. A. (2009). EVALUATION OF THE SERRATIA MARCESCENS NUCLEASE (NucA) AS A TRANSGENIC CELL ABLATION SYSTEM IN PORCINE. ANIMAL BIOTECHNOLOGY, 20(4), 177–185. https://doi.org/10.1080/10495390903048235 Farmer, W. T., Farin, P. W., Bischoff, S. R., Alexander, J. E., Piedrahita, J. A., & Farin, C. E. (2008). 2 DETECTION OF ANTISENSE TO Igf2r (AIR) RNA IN CATTLE. Reproduction, Fertility and Development, 20(1), 81. https://doi.org/10.1071/RDv20n1Ab2 Tsai, S., Hardison, N., Bischoff, S., Thames, B., Jamessd, A., Motsinger-Reif, A., & Piedrahita, J. (2008). 262: Molecular signatures of preeclampsia in human term placentas. American Journal of Obstetrics and Gynecology, 199(6), S84. https://doi.org/10.1016/j.ajog.2008.09.290 Lee, E., Estrada, J., & Piedrahita, J. A. (2008). A comparative study on the efficiency of two enucleation methods in pig somatic cell nuclear transfer: Effects of the squeezing and the aspiration methods. ANIMAL BIOTECHNOLOGY, 19(2), 71–79. https://doi.org/10.1080/10495390701839264 Zaunbrecher, G. M., Mir, B., Dunne, P. W., Breen, M., & Piedrahita, J. A. (2008). Enhancement of extra chromosomal recombination in somatic cells by affecting the ratio of homologous recombination (HR) to non-homologous end joining (NHEJ). ANIMAL BIOTECHNOLOGY, 19(1), 6–21. https://doi.org/10.1080/10495390701670099 Bischoff, S. R., Tsai, S., Hardison, N. E., York, A. M., Freking, B. A., Nonneman, D., … Piedrahita, J. A. (2008). Identification of SNPs and INDELS in swine transcribed sequences using short oligonucleotide microarrays. BMC Genomics, 9(1), 252. https://doi.org/10.1186/1471-2164-9-252 Estrada, J. L., Collins, B., York, A., Bischoff, S., Sommer, J., Tsai, S., … Piedrahita, J. A. (2008, June). Successful cloning of the Yucatan minipig using commercial/occidental breeds as oocyte donors and embryo recipients. CLONING AND STEM CELLS, Vol. 10, pp. 287–296. https://doi.org/10.1089/clo.2008.0005 Estrada, J., Sommer, J., Collins, B., Mir, B., Martin, A., York, A., … Piedrahita, J. A. (2007). Swine generated by somatic cell nuclear transfer have increased incidence of intrauterine growth restriction (IUGR). CLONING AND STEM CELLS, 9(2), 229–236. https://doi.org/10.1089/clo.2006.0079 Piedrahita, J., Bischoff, S., Estrada, J., Freking, B., Nonneman, D., Martin, A., … Tsai, S. (2006). 263 USE OF PORCINE PARTHENOTES AND GENE EXPRESSION PROFILING USING MICROARRAYS FOR IDENTIFICATION OF IMPRINTED GENES. Reproduction, Fertility and Development, 18(2), 239. https://doi.org/10.1071/RDv18n2Ab263 Estrada, J., Lee, E., & Piedrahita, J. (2006). 32 CRYOPRESERVATION OF DONOR CELLS FOR NUCLEAR TRANSFER: EFFECT OF CELL FREEZING METHOD ON THE EFFICIENCY OF SOMATIC CELL NUCLEAR TRANSFER IN PIGS. Reproduction, Fertility and Development, 18(2), 125. https://doi.org/10.1071/RDv18n2Ab32 Tsai, S., Cassady, J. P., Freking, B. A., Nonneman, D. J., Rohrer, G. A., & Piedrahita, J. A. (2006, August). Annotation of the Affymetrix(1) porcine genome microarray. ANIMAL GENETICS, Vol. 37, pp. 423–424. https://doi.org/10.1111/j.1365-2052.2006.01460.x Monteiro-Riviere, N., Inman, A., Hedgpeth, V., Mosteller, B., & Piedrahita, J. (2006). Dermatological effects of chronic exposure to 7,12-dimethylbenz[a]anthracene (DMBA) or N-methyl-N-nitrosoguanidine (MNNG) in swine. CUTANEOUS AND OCULAR TOXICOLOGY, 25(2), 103–119. https://doi.org/10.1080/15569520600695546 Tsai, S., Mir, B., Martin, A. C., Estrada, J. L., Bischoff, S. R., Hsieh, W. P., … Piedrahita, J. A. (2006). Detection of transcriptional difference of porcine imprinted genes using different microarray platforms. BMC Genomics, 7, 328–336. Farin, P. W., Piedrahita, J. A., & Farin, C. E. (2006, January 7). Errors in development of fetuses and placentas from in vitro-produced bovine embryos. THERIOGENOLOGY, Vol. 65, pp. 178–191. https://doi.org/10.1016/j.theriogenology.2005.09.022 Mir, B., Zaunbrecher, G., & Piedrahita, J. A. (2005). 51 PHENOTYPIC VARIATION IN CLONED SWINE IS CORRECTED IN THE F1 GENERATION. Reproduction, Fertility and Development, 17(2), 175. https://doi.org/10.1071/RDv17n2Ab51 Spiegelstein, O., Gould, A., Wlodarczyk, B., Tsie, M., Lu, X. F., Le, C., … Finnell, R. H. (2005). Developmental consequences of in utero sodium arsenate exposure in mice with folate transport deficiencies. TOXICOLOGY AND APPLIED PHARMACOLOGY, 203(1), 18–26. https://doi.org/10.1016/j.taap.2004.07.006 Ma, D. W. L., Finnell, R. H., Davidson, L. A., Callaway, E. S., Spiegelstein, O., Piedrahita, J. A., … Chapkin, R. S. (2005). Folate transport gene inactivation in mice increases sensitivity to colon carcinogenesis. Cancer Research, 65(3), 887–897. Mir, B., Zaunbrecher, G., Archer, G. S., Friend, T. H., & Piedrahita, J. A. (2005). Progeny of somatic cell nuclear transfer (SCNT) pig clones are phenotypically similar to non-cloned pigs. CLONING AND STEM CELLS, 7(2), 119–125. https://doi.org/10.1089/clo.2005.7.119 Mir, B., & Piedrahita, J. A. (2004). 343NUCLEAR LOCALIZATION SIGNAL AND CELL SYNCHRONY ENHANCES GENE TARGETING EFFICIENCY IN FETAL BOVINE FIBROBLASTS. Reproduction, Fertility and Development, 16(2), 291. https://doi.org/10.1071/RDv16n1Ab343 Dindot, S. V., Farin, P., Farin, C., Alexander, J., Crosier, E., Walker, S., … Piedrahita, J. A. (2004). 35 Analysis of epigenetic modifications and genomic imprinting in nuclear transfer derived Bos Gaurus x B. Taurus Concepti. Reproduction, Fertility and Development, 16(2), 140. https://doi.org/10.1071/RDv16n1Ab35 Piedrahita, J. A., Walker, S., & Zaunbrecher, G. (2004). 67ORGAN WEIGHT VARIATION IN CLONED PIGS. Reproduction, Fertility and Development, 16(2), 155. https://doi.org/10.1071/RDv16n1Ab67 Piedrahita, J. A., & Mir, B. (2004). Cloning and transgenesis in mammals: Implications for xenotransplantation. AMERICAN JOURNAL OF TRANSPLANTATION, 4, 43–50. https://doi.org/10.1111/j.1600-6135.2004.0344.x Seabury, C. M., Womack, J. E., Piedrahita, J., & Derr, J. N. (2004). Comparative PRNP genotyping of US cattle sires for potential association with BSE. MAMMALIAN GENOME, 15(10), 828–833. https://doi.org/10.1007/s00335-004-2400-6 Dindot, S., Kent, K. C., Evers, B., Loskutoff, N., Womack, J., & Piedrahita, J. A. (2004). Conservation of genomic imprinting at the XIST, IGF2, and GTL2 loci in the bovine. Mammalian Genome, 15(12), 966–974. https://doi.org/10.1007/s00335-004-2407-z Farin, C., Farin, P. W., & Piedrahita, J. A. (2004). Development of fetuses from in vitro produced and cloned bovine embryos. Journal of Animal Science, 82(Supplement 13), E53–E62. https://doi.org/10.2527/2004.8213_supplE53x Dindot, S. V., Farin, P. W., Farin, C. E., Romano, J., Walker, S., Long, C., & Piedrahita, J. A. (2004). Epigenetic and genomic imprinting analysis in nuclear transfer derived Bos gaurus/Bos taurus hybrid fetuses. Biology of Reproduction, 71(2), 470–478. https://doi.org/10.1095/biolreprod.103.025775 Mir, B., & Piedrahita, J. A. (2004). Nuclear localization signal and cell synchrony enhance gene targeting efficiency in primary fetal fibroblasts. Nucleic Acids Research, 32(3), e25–e28. https://doi.org/10.1093/nar/gnh023 Piedrahita, J. A., Mir, B., Dindot, S., & Walker, S. (2004). Somatic cell cloning: The ultimate form of nuclear reprogramming? JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 15(5), 1140–1144. https://doi.org/10.1097/01.ASN.0000110183.87476.05 Benjamin, C. L., Jenster, G., & Piedrahita, J. A. (2004). Use of artificial androgen receptor coactivators to alter myoblast proliferation. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 91(3), 111–119. https://doi.org/10.1016/j.jsbmb.2004.02.007 Archer, G., Friend, T., Piedrahita, J. A., Nevill, C., & Walker, S. C. (2003). Behavioral variation among cloned pigs. Applied Animal Behaviour Science, 81(4), 321–331. https://doi.org/10.1016/S0168-1591(02)00272-1 Archer, G., Friend, T., Piedrahita, J. A., Nevill, C., & Walker, S. C. (2003). Behavioral variation among cloned pigs. Applied Animal Behaviour Science, 82(2), 151–161. https://doi.org/10.1016/S0168-1591(03)00065-0 Archer, G. S., Dindot, S., Friend, T. H., Walker, S., Zaunbrecher, G., Lawhorn, B., & Piedrahita, J. A. (2003). Hierarchical phenotypic and epigenetic variation in cloned swine. BIOLOGY OF REPRODUCTION, 69(2), 430–436. https://doi.org/10.1095/biolreprod.103.016147 Kim, H. T., Song, I. Y., & Piedrahita, J. (2003). Kidney-specific activity of the bovine uromodulin promoter. TRANSGENIC RESEARCH, 12(2), 191–201. https://doi.org/10.1023/A:1022911124946 Thomson, J. G., Rucker, E. B., & Piedrahita, J. A. (2003). Mutational analysis of LoxP sites for efficient Cre-mediated insertion into genomic DNA. GENESIS, 36(3), 162–167. https://doi.org/10.1002/gene.10211 Mir, B., Tanner, N., Chowdhary, B. P., & Piedrahita, J. A. (2003). UP1 extends life of primary porcine fetal fibroblasts in culture. CLONING AND STEM CELLS, 5(2), 143–148. https://doi.org/10.1089/153623003322234740 Walker, S. C., Shin, T. Y., Zaunbrecher, G. M., Romano, J. E., Johnson, G. A., Bazer, F. W., & Piedrahita, J. A. (2002). A highly efficient method for porcine cloning by nuclear transfer using in vitro-matured oocytes. Cloning and Stem Cells, 2, 105–112. https://doi.org/10.1089/153623002320253283 Piedrahita, J. A., Wells, D. N., Miller, A. L., Oliver, J. E., Berg, M. C., Peterson, A. J., & Tervit, H. R. (2002). Effects of follicular size of cytoplast donor on the efficiency of cloning in cattle. MOLECULAR REPRODUCTION AND DEVELOPMENT, 61(3), 317–326. https://doi.org/10.1002/mrd.10013 Lee, C. K., & Piedrahita, J. A. (2002). Inhibition of apoptosis in serum starved porcine embryonic fibroblasts. MOLECULAR REPRODUCTION AND DEVELOPMENT, 62(1), 106–112. https://doi.org/10.1002/mrd.10058 Lee, C. K., & Piedrahita, J. A. (2001). Inactivation of the whey acidic protein (WAP) gene by site-specific recombination in mouse embryonic stem cells. Journal of Animal Science, 42(6), 941–956. Barthel, R., Feng, J., Piedrahita, J. A., McMurray, D. N., Templeton, J. W., & Adams, L. G. (2001). Stable transfection of the bovine NRAMP1 gene into murine RAW264.7 cells: effect on Brucella abortus survival. Infection and Immunity, 69(5), 3110–3119. https://doi.org/10.1128/IAI.69.5.3110-3119.2001 Miller, S., Kennedy, D., Thomson, J., Han, F., Smith, R., Ing, N., … Busbee, D. (2000). A rapid and sensitive reporter gene that uses green fluorescent protein expression to detect chemicals with estrogenic activity. TOXICOLOGICAL SCIENCES, 55(1), 69–77. https://doi.org/10.1093/toxsci/55.1.69 Lee, C.-K., & Piedrahita, J. A. (2000). Effects of growth factors and feeder cells on porcine primordial germ cells in vitro. Cloning and Stem Cells, 2, 197–206. https://doi.org/10.1089/152045500454753 Lee, C. K., Weaks, R. L., Johnson, G. A., Bazer, F. W., & Piedrahita, J. A. (2000). Effects of protease inhibitors and antioxidants on in vitro survival of porcine primordial germ cells. BIOLOGY OF REPRODUCTION, 63(3), 887–897. https://doi.org/10.1095/biolreprod63.3.887 Piedrahita, J. A. (2000). Gene targeting in domestic species: A new beginning. Transgenic Res, 9(4/5), 261–262. https://doi.org/10.1023/A:1008984711570 Lee, C. K., Moore, K., Scales, N., Westhusin, M., Newton, G., Im, K. S., & Piedrahita, J. A. (2000). Isolation and genetic transformation of primordial germ cell (PGC)-derived cells from cattle, goats, rabbits and rats. ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES, 13(5), 587–594. https://doi.org/10.5713/ajas.2000.587 Barthel, R., Piedrahita, J. A., McMurray, D. N., Payeur, J., Baca, D., Guemes, F. S., … Adams, L. G. (2000). Pathologic findings and association of Mycobacterium bovis infection with the bovine NRAMP1 gene in cattle from herds with naturally occurring tuberculosis. AMERICAN JOURNAL OF VETERINARY RESEARCH, 61(9), 1140–1144. https://doi.org/10.2460/ajvr.2000.61.1140 Westhusin, M., & Piedrahita, J. (2000). Three little pigs worth the huff and puff? Nature Biotechnology, 18(11), 1144–1145. https://doi.org/10.1038/81119 Piedrahita, J. A., Oetama, B., Bennett, G., Waes, J. V., Lacey, S. W., Kamen, B., … Finnell, R. (1999). Inactivation of the folate binding protein genes disrupts neural tube closure. Nature Genetics, 23, 228–232. Ramsoondar, J. J., Christopherson, R. J., Guilbert, L. J., Dixon, W. T., Ghahary, A., Ellis, S., … Piedrahita, J. A. (1999). Regulated Expression of MHC class I molecules in the porcine embryo. Biology of Reproduction, 60, 387–397. Atshaves, B. P., Foxworth, W. B., Frolov, A., Roths, J. B., Kier, A. B., Oetama, B. K., … Schroeder, F. (1998). Cellular differentiation and I-FABP protein expression modulate fatty acid uptake and diffusion. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 274(3), C633–C644. https://doi.org/10.1152/ajpcell.1998.274.3.c633 Vazquez, J. C., Nogues, C., Rucker, E. B., & Piedrahita, J. A. (1998). Factors affecting the efficiency of introducing precise genetic changes in ES cells by homologous recombination: tag-and-exchange versus the Cre-loxp system. TRANSGENIC RESEARCH, 7(3), 181–193. https://doi.org/10.1023/A:1008888929552 Piedrahita, J. A., Moore, K., Oetama, B., Lee, C. K., Scales, N., Ramsoondar, J., … Ott, T. (1998). Generation of transgenic porcine chimeras using primordial germ cell-derived colonies. BIOLOGY OF REPRODUCTION, 58(5), 1321–1329. https://doi.org/10.1095/biolreprod58.5.1321 Ramsoondar, J., Vazques, J. C., Rucker, E., Dickson, R., Lunney, J., & Piedrahita, J. A. (1998). Isolation, characterization, and polymorphism detection of the porcine apolipoprotein E gene. Animal Genetics, 29, 43–47. https://doi.org/10.1046/j.1365-2052.1998.00273.x Rucker, E., & Piedrahita, J. A. (1997). Cre-mediated site-directed insertions at the mouse whey acidic protein (mWAP) locus. Molecular Reproduction and Development, 48, 324–331. https://doi.org/10.1002/(sici)1098-2795(199711)48:3<324::aid-mrd4>3.3.co;2-q Moore, K., & Piedrahita, J. A. (1997). Effect of LIF and culture media on the in vitro differentiation of isolated porcine inner cell masses. In Vitro Cellular & Developmental Biology. Animal, 33, 61–70. Piedrahita, J. A., Weaks, R., Petrescu, A., Shrode, T. W., Derr, J. N., & Womack, J. E. (1997). Genetic characterization of the bovine leukaemia inhibitory factor (LIF) gene: Isolation and sequencing, chromosome assignment and microsatellite analysis. ANIMAL GENETICS, 28(1), 14–20. https://doi.org/10.1111/j.1365-2052.1997.00054.x Weaks, R., Ramsoondar, J., Gallager, D., Nogues, C., & Piedrahita, J. A. (1997). Isolation, characterization, and chromosome assignment of the porcine ciliary neurotrophic factor. Animal Genetics, 28, 354–357. Piedrahita, J. A., Moore, K., Lee, C., Weaks, R., Ramsoondar, J., Oetama, B., & Vasquez, J. (1997). Progress on the generation of transgenic pigs via cultured cells. Journal of Reproduction & Fertility, 52, 245–254. Finnell, R. H., Wlodarczyk, B. C., Craig, J. C., Piedrahita, J. A., & Bennett, G. D. (1997). Strain dependent alterations in the expression of folate pathway genes following teratogenic exposure to valproic acid in a mouse model. American Journal of Medical Genetics. Part A, 70, 303–311. https://doi.org/10.1002/(sici)1096-8628(19970613)70:3<303::aid-ajmg17>3.3.co;2-a Moore, K., & Piedrahita, J. A. (1996). Effect of hematopoetic cytokines on in vitro differentiation of isolated porcine inner cell masses. Molecular Reproduction and Development, 45, 139–144. SAPATINO, B. V., PETRESCU, A. D., ROSENBAUM, B. A., SMITH, R., PIEDRAHITA, J. A., & WELSH, C. J. R. (1995). CHARACTERISTICS OF CLONED CEREBROVASCULAR ENDOTHELIAL-CELLS FOLLOWING INFECTION WITH THEILERS VIRUS .2. PERSISTENT INFECTION. JOURNAL OF NEUROIMMUNOLOGY, 62(2), 127–135. https://doi.org/10.1016/0165-5728(95)00094-4 PIEDRAHITA, J. A., ZHANG, S. H., HAGAMAN, JR, OLIVER, P. M., & MAEDA, N. (1992). GENERATION OF MICE CARRYING A MUTANT APOLIPOPROTEIN-E GENE INACTIVATED BY GENE TARGETING IN EMBRYONIC STEM-CELLS. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 89(10), 4471–4475. https://doi.org/10.1073/pnas.89.10.4471 PIEDRAHITA, J. A., GILLESPIE, L., & MAEDA, N. (1992). PRODUCTION OF CHIMERIC HAMSTERS BY AGGREGATION OF 8-CELL EMBRYOS. BIOLOGY OF REPRODUCTION, 47(3), 347–354. https://doi.org/10.1095/biolreprod47.3.347 ZHANG, S. H., REDDICK, R. L., PIEDRAHITA, J. A., & MAEDA, N. (1992). SPONTANEOUS HYPERCHOLESTEROLEMIA AND ARTERIAL LESIONS IN MICE LACKING APOLIPOPROTEIN-E. SCIENCE, 258(5081), 468–471. https://doi.org/10.1126/science.1411543 PIEDRAHITA, J. A., ANDERSON, G. B., & BONDURANT, R. H. (1990). INFLUENCE OF FEEDER LAYER TYPE ON THE EFFICIENCY OF ISOLATION OF PORCINE EMBRYO-DERIVED CELL-LINES. THERIOGENOLOGY, 34(5), 865–877. https://doi.org/10.1016/0093-691X(90)90558-B PIEDRAHITA, J. A., ANDERSON, G. B., & BONDURANT, R. H. (1990). ON THE ISOLATION OF EMBRYONIC STEM-CELLS - COMPARATIVE BEHAVIOR OF MURINE, PORCINE AND OVINE EMBRYOS. THERIOGENOLOGY, 34(5), 879–901. https://doi.org/10.1016/0093-691X(90)90559-C BOOMAN, P., KRUIJT, L., TIEMAN, M., PIEDRAHITA, J. A., VEERHUIS, R., DEBOER, P., & RUCH, F. E. (1989). PRODUCTION AND CHARACTERIZATION OF MONOCLONAL-ANTIBODIES AGAINST THE H-Y-ANTIGEN. JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 15(3), 195–205. https://doi.org/10.1016/0165-0378(89)90011-9 Piedrahita, J. A., & Anderson, G. B. (1985). Investigation of sperm cytotoxicity as an indicator of ability of antisera to detect male-specific antigen on preimplantation mouse embryos. Journal of Reproduction & Fertility, 74, 637–644. https://doi.org/10.1530/jrf.0.0740637