@article{rivas_tan_shaverdian_nguyen_wouters_stern_li_2024, title={A novel <i>ITGA2B</i> double cytosine frameshift variant (c.1986_1987insCC) leads to Glanzmann&apos;s thrombasthenia in a cat}, volume={3}, ISSN={["1939-1676"]}, url={https://doi.org/10.1111/jvim.17030}, DOI={10.1111/jvim.17030}, abstractNote={Abstract}, journal={JOURNAL OF VETERINARY INTERNAL MEDICINE}, author={Rivas, Victor N. and Tan, Avalene W. K. and Shaverdian, Meg and Nguyen, Nghi P. and Wouters, Jalena R. and Stern, Joshua A. and Li, Ronald H. L.}, year={2024}, month={Mar} }
 @article{walker_li_nguyen_jauregui_meurs_gagnon_stern_2023, title={Evaluation of autoantibodies to desmoglein-2 in dogs with and without cardiac disease}, volume={13}, ISSN={2045-2322}, url={http://dx.doi.org/10.1038/s41598-023-32081-x}, DOI={10.1038/s41598-023-32081-x}, abstractNote={Abstract}, number={1}, journal={Scientific Reports}, publisher={Springer Science and Business Media LLC}, author={Walker, Ashley L. and Li, Ronald H. L. and Nguyen, Nghi and Jauregui, Carina E. and Meurs, Kathryn M. and Gagnon, Allison L. and Stern, Joshua A.}, year={2023}, month={Mar} }
 @article{stern_2023, title={Exciting Advancements and Compelling Future Directions in Companion Animal Cardiology}, volume={53}, ISSN={["1878-1306"]}, DOI={10.1016/j.cvsm.2023.08.009}, number={6}, journal={VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE}, author={Stern, Joshua A.}, year={2023}, month={Nov} }
 @article{stern_rivas_kaplan_ueda_oldach_ontiveros_kooiker_dijk_harris_2023, title={Hypertrophic cardiomyopathy in purpose-bred cats with the A31P mutation in cardiac myosin binding protein-C}, volume={13}, ISSN={["2045-2322"]}, url={https://publons.com/wos-op/publon/63367066/}, DOI={10.1038/s41598-023-36932-5}, abstractNote={Abstract}, number={1}, journal={SCIENTIFIC REPORTS}, author={Stern, Joshua A. and Rivas, Victor N. and Kaplan, Joanna L. and Ueda, Yu and Oldach, Maureen S. and Ontiveros, Eric S. and Kooiker, Kristina B. and Dijk, Sabine J. and Harris, Samantha P.}, year={2023}, month={Jun} }
 @article{rivas_kaplan_kennedy_fitzgerald_crofton_farrell_grubb_jauregui_grigorean_choi_et al._2023, title={Multi-Omic, Histopathologic, and Clinicopathologic Effects of Once-Weekly Oral Rapamycin in a Naturally Occurring Feline Model of Hypertrophic Cardiomyopathy: A Pilot Study}, volume={13}, ISSN={["2076-2615"]}, url={https://doi.org/10.3390/ani13203184}, DOI={10.3390/ani13203184}, abstractNote={Hypertrophic cardiomyopathy (HCM) remains the single most common cardiomyopathy in cats, with a staggering prevalence as high as 15%. To date, little to no direct therapeutical intervention for HCM exists for veterinary patients. A previous study aimed to evaluate the effects of delayed-release (DR) rapamycin dosing in a client-owned population of subclinical, non-obstructive, HCM-affected cats and reported that the drug was well tolerated and resulted in beneficial LV remodeling. However, the precise effects of rapamycin in the hypertrophied myocardium remain unknown. Using a feline research colony with naturally occurring hereditary HCM (n = 9), we embarked on the first-ever pilot study to examine the tissue-, urine-, and plasma-level proteomic and tissue-level transcriptomic effects of an intermittent low dose (0.15 mg/kg) and high dose (0.30 mg/kg) of DR oral rapamycin once weekly. Rapamycin remained safe and well tolerated in cats receiving both doses for eight weeks. Following repeated weekly dosing, transcriptomic differences between the low- and high-dose groups support dose-responsive suppressive effects on myocardial hypertrophy and stimulatory effects on autophagy. Differences in the myocardial proteome between treated and control cats suggest potential anti-coagulant/-thrombotic, cellular remodeling, and metabolic effects of the drug. The results of this study closely recapitulate what is observed in the human literature, and the use of rapamycin in the clinical setting as the first therapeutic agent with disease-modifying effects on HCM remains promising. The results of this study establish the need for future validation efforts that investigate the fine-scale relationship between rapamycin treatment and the most compelling gene expression and protein abundance differences reported here.}, number={20}, journal={ANIMALS}, author={Rivas, Victor N. and Kaplan, Joanna L. and Kennedy, Susan A. and Fitzgerald, Stuart and Crofton, Amanda E. and Farrell, Aisling and Grubb, Louise and Jauregui, Carina E. and Grigorean, Gabriela and Choi, Eunju and et al.}, year={2023}, month={Oct} }
 @article{reimann_faisst_knold_meurs_stern_cremer_moller_ljungvall_haggstrom_olsen_2023, title={No impact of polymorphism in the phosphodiesterase 5A gene in Cavalier King Charles Spaniels on pimobendan-induced inhibition of platelet aggregation response}, volume={9}, ISSN={["1939-1676"]}, DOI={10.1111/jvim.16871}, abstractNote={Abstract}, journal={JOURNAL OF VETERINARY INTERNAL MEDICINE}, author={Reimann, Maria J. and Faisst, Daniel N. and Knold, Mads and Meurs, Kathryn M. and Stern, Joshua A. and Cremer, Signe E. and Moller, Jacob E. and Ljungvall, Ingrid and Haggstrom, Jens and Olsen, Lisbeth H.}, year={2023}, month={Sep} }
 @article{rivas_ueda_stern_2023, title={Sex-specific differences and predictors of echocardiographic measures of diastolic dysfunction in rhesus macaques (Macaca mulatta)}, volume={7}, ISSN={["1600-0684"]}, url={https://doi.org/10.1111/jmp.12662}, DOI={10.1111/jmp.12662}, abstractNote={Abstract}, journal={JOURNAL OF MEDICAL PRIMATOLOGY}, author={Rivas, Victor N. and Ueda, Yu and Stern, Joshua A.}, year={2023}, month={Jul} }
 @misc{crofton_kovacs_stern_2023, title={Subvalvular Aortic Stenosis: Learning From Human and Canine Clinical Research}, volume={14}, ISSN={["1923-2837"]}, DOI={10.14740/cr1547}, abstractNote={Subvalvular aortic stenosis (SAS) is the most common congenital heart disease (CHD) in dogs and is also prevalent in human children. A fibrous ridge below the aortic valve narrows the left ventricular outflow tract (LVOT) and increases blood flow velocity, leading to devastating side effects in diseased patients. Due to the similarities in presentation, anatomy, pathophysiology, cardiac development, genomics, and environment between humans and dogs, canine SAS patients represent a critical translational model of human SAS. Potential adverse outcomes of SAS include arrhythmias, left-sided congestive heart failure, endocarditis, exercise intolerance, syncope, and sudden cardiac death. The greatest divergence between canine and human SAS clinical research has been the standard of care regarding treatment of these outcomes, with pharmacological intervention dominating best practices in veterinary medicine and surgical intervention comprising the standard practice for human SAS patients. Regardless of the species, the field has yet to identify a treatment option to prevent disease progression or permanently remove the fibrous ridge, but historical leaps in SAS research support a continued translational approach as the most promising method for achieving this goal.}, number={5}, journal={CARDIOLOGY RESEARCH}, author={Crofton, Amanda E. and Kovacs, Samantha L. and Stern, Joshua A.}, year={2023}, month={Oct}, pages={319–333} }
 @article{rivas_stern_ueda_2023, title={The Role of Personalized Medicine in Companion Animal Cardiology}, volume={53}, ISSN={["1878-1306"]}, url={https://publons.com/wos-op/publon/65523949/}, DOI={10.1016/j.cvsm.2023.05.016}, abstractNote={Cardiomyopathies remain one of the most common inherited cardiac diseases in both human and veterinary patients. To date, well over 100 mutated genes are known to cause cardiomyopathies in humans with only a handful known in cats and dogs. This review highlights the need and use of personalized one-health approaches to cardiovascular case management and advancement in pharmacogenetic-based therapy in veterinary medicine. Personalized medicine holds promise in understanding the molecular basis of disease and ultimately will unlock the next generation of targeted novel pharmaceuticals and aid in the reversal of detrimental effects at a molecular level.}, number={6}, journal={VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE}, author={Rivas, Victor N. and Stern, Joshua A. and Ueda, Yu}, year={2023}, month={Nov}, pages={1255–1276} }