immunology, immunogenetics, immunotoxicology, genomics, DNA methylation, DNA methyltransferases
Dr. Jeff Yoder graduated from Worcester Polytechnic Institute with a B.S. in Biotechnology and performed his graduate work with Dr. Tim Bestor receiving his Ph.D. in Cell and Developmental Biology from Harvard University’s graduate program in Biological and Biomedical Sciences. He then did a post-doc with Dr. Gary Litman at the University of South Florida. Jeff was faculty at the University of South Florida before joined the faculty at NC State University in 2004. Jeff's current research interests are on identifying and characterizing novel mediators of innate immunity. His research employs the zebrafish model to study the genetic and functional evolution of innate immune receptors, for examining the immunotoxicological effects of environmental chemicals, and as a model for identifying novel mediators of immunity. His current studies on the evolution of immune receptors integrates genomic and transcriptomic data from all vertebrate lineages. His current immunotoxicology research employs zebrafish and cell culture models to study the impact of exposure to per- and polyfluoroalkyl substances (PFAS) on immune function. This research is highly interdisciplinary and includes collaborations with evolutionary biologists, structural biochemists, toxicologists, chemists, engineers and field biologists. His research has been funded by NIH, NIEHS, NSF, MAF, TriCEM and a variety of foundations and agencies.
2024 journal article
Per- and polyfluoroalkyl substances alter innate immune function: evidence and data gaps
Journal of Immunotoxicology, 21(1).
Contributors: D. Phelps n , A. Connors n , G. Ferrero n, J. DeWitt n & n
2023 article
A chromosome-level genome assembly of longnose gar, Lepisosteus osseus
Mallik, R., Carlson, K. B., Wcisel, D. J., Fisk, M., Yoder, J. A., & Dornburg, A. (2023, April 29). (N. Whiteman, Ed.). G3-GENES GENOMES GENETICS, Vol. 4.
Ed(s): N. Whiteman
2023 article
Ancient Fish Lineages Illuminate Toll-Like Receptor Diversification in Early Vertebrate Evolution
Carlson, K. B., Nguyen, C., Wcisel, D. J., Yoder, J. A., & Dornburg, A. (2023, April 6).
2023 article
Ancient fish lineages illuminate toll-like receptor diversification in early vertebrate evolution
Carlson, K. B., Nguyen, C., Wcisel, D. J., Yoder, J. A., & Dornburg, A. (2023, August 9). IMMUNOGENETICS, Vol. 8.
2023 journal article
Automated, high-throughput quantification of EGFP-expressing neutrophils in zebrafish by machine learning and a highly-parallelized microscope
PLOS ONE, 18(12).
2023 article
Human DOCK11 Deficiency Causes Defective Erythropoiesis and Systemic Inflammation
Block, J., Rashkova, C., Castanon, I., Platon, J., Zoghi, S., Fujiwara, M., … Boztug, K. (2023, November 2). BLOOD, Vol. 142.
2023 article
Investigating the impact of whole genome duplication on transposable element evolution in ray-finned fishes
Mallik, R., Wcisel, D. J., Near, T. J., Yoder, J. A., & Dornburg, A. (2023, December 23).
2023 journal article
Legacy and emerging per- and polyfluoroalkyl substances suppress the neutrophil respiratory burst
JOURNAL OF IMMUNOTOXICOLOGY, 20(1).
2023 article
Systemic Inflammation and Normocytic Anemia in DOCK11 Deficiency
Block, J., Rashkova, C., Castanon, I., Zoghi, S., Platon, J., Ardy, R. C., … Boztug, K. (2023, June 21). NEW ENGLAND JOURNAL OF MEDICINE, Vol. 6.
2022 article
A chromosome level genome assembly of longnose gar,Lepisosteus osseus
Mallik, R., Carlson, K. B., Wcisel, D. J., Fisk, M., Yoder, J. A., & Dornburg, A. (2022, December 22).
2022 article
A highly diverse set of novel immunoglobulin-like transcript (NILT) genes in zebrafish indicates a wide range of functions with complex relationships to mammalian receptors
Wcisel, D. J., Dornburg, A., McConnell, S. C., Hernandez, K. M., Andrade, J., Jong, J. L. O., … Yoder, J. A. (2022, July 23). IMMUNOGENETICS, Vol. 7.
2022 article
A highly diverse set of novel immunoglobulin-like transcript (NILT) genes in zebrafish indicates a wide range of functions with complex relationships to mammalian receptors
Wcisel, D. J., Dornburg, A., McConnell, S. C., Hernandez, K. M., Andrade, J., Jong, J. L. O., … Yoder, J. A. (2022, April 22). (Vol. 4). Vol. 4.
2022 journal article
Knockdown of Transmembrane Protein 150A (TMEM150A) Results in Increased Production of Multiple Cytokines
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 42(7), 336–342.
2022 article
On the relationship between extant innate immune receptors and the evolutionary origins of jawed vertebrate adaptive immunity
Dornburg, A., & Yoder, J. A. (2022, January 4). IMMUNOGENETICS, Vol. 74.
2022 review
Placing human gene families into their evolutionary context
[Review of ]. HUMAN GENOMICS, 16(1).
2022 article
Transcriptome annotation reveals minimal immunogenetic diversity among Wyoming toads, Anaxyrus baxteri
Carlson, K. B., Wcisel, D. J., Ackerman, H. D., Romanet, J., Christiansen, E. F., Niemuth, J. N., … Yoder, J. A. (2022, April 28). CONSERVATION GENETICS, Vol. 4.
2021 journal article
A Zebrafish Model of Metastatic Colonization Pinpoints Cellular Mechanisms of Circulating Tumor Cell Extravasation
FRONTIERS IN ONCOLOGY, 11.
2021 personal communication
From IgZ to IgT: A Call for a Common Nomenclature for Immunoglobulin Heavy Chain Genes of Ray-Finned Fish
Dornburg, A., Ota, T., Criscitiello, M. F., Salinas, I., Sunyer, J. O., Magadan, S., … Yoder, J. A. (2021, December 1).
2021 article
Holosteans contextualize the role of the teleost genome duplication in promoting the rise of evolutionary novelties in the ray-finned fish innate immune system
Dornburg, A., Wcisel, D. J., Zapfe, K., Ferraro, E., Roupe-Abrams, L., Thompson, A. W., … Yoder, J. A. (2021, June 11). (Vol. 6). Vol. 6.
2021 journal article
Holosteans contextualize the role of the teleost genome duplication in promoting the rise of evolutionary novelties in the ray-finned fish innate immune system
Immunogenetics.
2021 journal article
Single-minded 2 is required for left-right asymmetric stomach morphogenesis
DEVELOPMENT, 148(17).
2021 article
The bowfin genome illuminates the developmental evolution of ray-finned fishes
Thompson, A. W., Hawkins, M. B., Parey, E., Wcisel, D. J., Ota, T., Kawasaki, K., … Braasch, I. (2021, August 30). NATURE GENETICS, Vol. 8.
2021 article
The evolution of innate immune receptors: investigating the diversity, distribution, and phylogeny of immune recognition across eukaryotes
Buckley, K. M., & Yoder, J. A. (2021, December 15). IMMUNOGENETICS, Vol. 74.
2020 journal article
In vivo assessment of respiratory burst inhibition by xenobiotic exposure using larval zebrafish
Journal of Immunotoxicology, 17(1), 94–104.
2020 journal article
Transcriptome Ortholog Alignment Sequence Tools (TOAST) for phylogenomic dataset assembly
BMC Evolutionary Biology, 20(1).
2019 journal article
Calcium imaging of primary canine sensory neurons: Small‐diameter neurons responsive to pruritogens and algogens
Brain and Behavior.
2019 chapter
Chapter 19 - Immunology
In The Zebrafish in Biomedical Research.
2019 journal article
Circulating tumor cells exit circulation while maintaining multicellularity, augmenting metastatic potential.
Journal of Cell Science.
2019 journal article
Presence of cerebrospinal fluid antibodies associated with autoimmune encephalitis of humans in dogs with neurologic disease
Journal of Veterinary Internal Medicine, 33(5), 2175–2182.
2018 journal article
Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon
Journal of Biological Chemistry, 293(16), 6187–6200.
2018 journal article
Use of a specific polyclonal anti-canine TSLP antibody reveals TSLP expression in normal tissue and cell culture
Journal of Veterinary Pharmacology and Therapeutics, 41, 153–153.
2017 journal article
BAC Recombineering of the Agouti Loci from Spotted Gar and Zebrafish Reveals the Evolutionary Ancestry of Dorsal–Ventral Pigment Asymmetry in Fish
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution.
2017 journal article
Disruption of Trim9 function abrogates macrophage motility in vivo
Journal of Leukocyte Biology, 102(6), 1371–1380.
2017 journal article
Evolutionary divergence of the vertebrate TNFAIP8 gene family: Applying the spotted gar orthology bridge to understand ohnolog loss in teleosts
PLOS ONE, 12(6), e0179517.
Ed(s): P. Boudinot
2017 journal article
Loss of DNA methylation in zebrafish embryos activates retrotransposons to trigger antiviral signaling
Development, 144(16), 2925–2939.
2017 journal article
Spotted Gar and the Evolution of Innate Immune Receptors
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 328(7), 666–684.
2016 journal article
Alternative haplotypes of antigen processing genes in zebrafish diverged early in vertebrate evolution
Proceedings of the National Academy of Sciences, 113(34), E5014–E5023.
2016 journal article
Angiopellosis as an Alternative Mechanism of Cell Extravasation
STEM CELLS, 35(1), 170–180.
2016 journal article
Erratum: Corrigendum: The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons
Nature Genetics, 48(6), 700–700.
2016 journal article
Phage display and structural studies reveal plasticity in substrate specificity of caspase-3a from zebrafish
Protein Science, 25(11), 2076–2088.
Contributors: M. Tucker n, S. MacKenzie n, J. Maciag n, H. Dirscherl Ackerman, P. Swartz n, n , P. Hamilton n , A. Clay Clark *
2016 review
Review of Automated Microinjection Systems for Single Cells in the Embryogenesis Stage
[Review of ]. IEEE-ASME TRANSACTIONS ON MECHATRONICS, 21(5), 2391–2404.
2016 journal article
Single-cell transcriptional analysis of normal, aberrant, and malignant hematopoiesis in zebrafish
The Journal of Cell Biology, 213(3), 2133OIA95.
2016 journal article
Single-cell transcriptional analysis of normal, aberrant, and malignant hematopoiesis in zebrafish
The Journal of Experimental Medicine, 213(6), 979–992.
2016 journal article
The confounding complexity of innate immune receptors within and between teleost species
Fish & Shellfish Immunology, 53, 24–34.
2016 journal article
The identification of additional zebrafish DICP genes reveals haplotype variation and linkage to MHC class I genes
Immunogenetics, 68(4), 295–312.
2016 journal article
The identification of additional zebrafish DICP genes reveals haplotype variation and linkage to MHC class I genes.
http://europepmc.org/abstract/med/26801775
2016 journal article
The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons
Nature Genetics, 48(4), 427–437.
2015 journal article
A nonclassical MHC class I U lineage locus in zebrafish with a null haplotypic variant
Immunogenetics, 67(9), 501–513.
2015 journal article
Machine learning reveals sex-specific 17β-estradiol-responsive expression patterns in white perch (Morone americana) plasma proteins
PROTEOMICS, 15(15), 2678–2690.
Contributors: J. Schilling n, A. Nepomuceno n, A. Planchart n , n , R. Kelly n , D. Muddiman n , H. Daniels n, N. Hiramatsu*, B. Reading n
2015 journal article
Neutralization of Mitochondrial Superoxide by Superoxide Dismutase 2 Promotes Bacterial Clearance and Regulates Phagocyte Numbers in Zebrafish
Infection and Immunity, 83(1), 430–440.
Ed(s): B. McCormick
2014 journal article
An ITAM in a Nonenveloped Virus Regulates Activation of NF- B, Induction of Beta Interferon, and Viral Spread
Journal of Virology, 88(5), 2572–2583.
2014 journal article
Differential expression and ligand binding indicate alternative functions for zebrafish polymeric immunoglobulin receptor (pIgR) and a family of pIgR-like (PIGRL) proteins
Immunogenetics, 66(4), 267–279.
2014 journal article
Multigene families of immunoglobulin domain-containing innate immune receptors in zebrafish: Deciphering the differences
Developmental & Comparative Immunology, 46(1), 24–34.
2014 journal article
Preface to the Special Issue: Zebrafish immunity and infection models
Developmental & Comparative Immunology, 46(1), 1–2.
2014 journal article
The MHC class I genes of zebrafish
Developmental & Comparative Immunology, 46(1), 11–23.
2013 journal article
A Myristoylated Alanine-Rich C Kinase Substrate–Related Peptide Suppresses Cytokine mRNA and Protein Expression in LPS-Activated Canine Neutrophils
American Journal of Respiratory Cell and Molecular Biology, 48(3), 314–321.
2013 journal article
A Semantic Model for Species Description Applied to the Ensign Wasps (Hymenoptera: Evaniidae) of New Caledonia
SYSTEMATIC BIOLOGY, 62(5), 639–659.
2013 journal article
Characterization of the Z lineage Major histocompatability complex class I genes in zebrafish
Immunogenetics, 66(3), 185–198.
2013 journal article
Super Resolution Microscopy Reveals that Caveolin-1 Is Required for Spatial Organization of CRFB1 and Subsequent Antiviral Signaling in Zebrafish
PLoS ONE, 8(7), e68759.
Ed(s): C. Lamaze
2012 journal article
A photoactivatable small-molecule inhibitor for light-controlled spatiotemporal regulation of Rho kinase in live embryos
Development, 139(2), 437–442.
2012 journal article
Development and Characterization of Anti-Nitr9 Antibodies
Advances in Hematology, 2012, 1–9.
2012 journal article
Genomic and functional characterization of the diverse immunoglobulin domain-containing protein (DICP) family
Genomics, 99(5), 282–291.
2012 conference paper
Myristoylated Alanine-Rich C Kinase Substrate (MARCKS) Protein Plays A Critical Role In Production Of Proinflammatory Cytokines By Isolated Canine Neutrophils
A67. ACUTE LUNG INJURY AND ACUTE RESPIRATORY DISTRESS SYNDROME: BIOLOGICAL MECHANISMS.
2012 journal article
Surface modifications on InAs decrease indium and arsenic leaching under physiological conditions
APPLIED SURFACE SCIENCE, 261, 842–850.
2011 journal article
Expression and function of triggering receptor expressed on myeloid cells-1 (TREM-1) on canine neutrophils
Developmental & Comparative Immunology, 35(8), 872–880.
2011 journal article
Two Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Paralogs are Required for Normal Development in Zebrafish
The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology, 294(9), 1511–1524.
2010 journal article
Photocaged Morpholino Oligomers for the Light-Regulation of Gene Function in Zebrafish and Xenopus Embryos
Journal of the American Chemical Society, 132(44), 15644–15650.
2010 journal article
Specific Resistance to Pseudomonas aeruginosa Infection in Zebrafish Is Mediated by the Cystic Fibrosis Transmembrane Conductance Regulator
Infection and Immunity, 78(11), 4542–4550.
2010 journal article
The phylogenetic origins of natural killer receptors and recognition: relationships, possibilities, and realities
Immunogenetics, 63(3), 123–141.
2009 journal article
Aquatic animal models of human disease: Selected papers and recommendations from the 4th Conference
Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 149(2), 121–128.
2009 journal article
Developmental and tissue-specific expression of NITRs
Immunogenetics, 62(2), 117–122.
2009 journal article
Enhanced transcription of complement and coagulation genes in the absence of adaptive immunity
Molecular Immunology, 46(7), 1505–1516.
2009 journal article
Light-activation of gene function in mammalian cells via ribozymes
Chem. Commun., (5), 568–570.
2009 journal article
Sp2 Is a Maternally Inherited Transcription Factor Required for Embryonic Development
Journal of Biological Chemistry, 285(6), 4153–4164.
2008 journal article
A critical role for DAP10 and DAP12 in CD8+ T cell-mediated tissue damage in large granular lymphocyte leukemia
Blood, 113(14), 3226–3234.
2008 journal article
Assessing infection and immunity in zebrafish
Zebrafish, 5(3), 189–191.
2008 journal article
Clinical improvement by farnesyltransferase inhibition in NK large granular lymphocyte leukemia associated with imbalanced NK receptor signaling
Blood, 112(12), 4694–4698.
2008 journal article
Evidence for a transposition event in a second NITR gene cluster in zebrafish
Immunogenetics, 60(5), 257–265.
2008 journal article
Form, function and phylogenetics of NITRs in bony fish
Developmental & Comparative Immunology, 33(2), 135–144.
2008 journal article
Gene Silencing in Mammalian Cells with Light-Activated Antisense Agents
ChemBioChem, 9(18), 2937–2940.
2008 journal article
The medaka novel immune-type receptor (NITR) gene clusters reveal an extraordinary degree of divergence in variable domains
BMC Evolutionary Biology, 8(1), 177.
2008 journal article
Workshop report - assessing infection and immunity in zebrafish
Zebrafish, 5, 189–191.
2007 article
Immunoglobulin variable regions in molecules exhibiting characteristics of innate and adaptive immune receptors
IMMUNOLOGIC RESEARCH, Vol. 38, pp. 294–304.
2007 journal article
Structural characteristics of zebrafish orthologs of adaptor molecules that associate with transmembrane immune receptors
Gene, 401(1-2), 154–164.
2007 journal article
The zebrafish activating immune receptor Nitr9 signals via Dap12
Immunogenetics, 59(10), 813–821.
2006 journal article
Conditional Transgene and Gene Targeting Methodologies in Zebrafish
Zebrafish, 3(4), 415–429.
2006 journal article
Immune-related, lectin-like receptors are differentially expressed in the myeloid and lymphoid lineages of zebrafish
Immunogenetics, 58(1), 31–40.
2006 journal article
Methylation of tRNAAsp by the DNA Methyltransferase Homolog Dnmt2
Science, 311(5759), 395–398.
2006 journal article
Role for retinoid signaling in left–right asymmetric digestive organ morphogenesis
Developmental Dynamics, 235(8), 2266–2275.
2004 journal article
Investigating the morphology, function and genetics of cytotoxic cells in bony fish
Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 138(3), 271–280.
2004 journal article
On the origins of adaptive immunity:possible clues from the SIRP and NITR multigene families
Trends in Immunology, 25, 11–16.
2004 journal article
Resolution of the novel immune-type receptor gene cluster in zebrafish
Proceedings of the National Academy of Sciences, 101(44), 15706–15711.
2003 journal article
Novel Immune-type Receptor Genes and the Origins of Adaptive and Innate Immune Recognition
Integrative and Comparative Biology, 43(2), 331–337.
2003 journal article
On the origins of adaptive immunity: Innate immune receptors join the tale
Trends in Immunology, 25(1), 11–16.
2003 article
The Zebrafish as a Model Organism to Study Development of the Immune System
Advances in Immunology, Vol. 81, pp. 254–330.
2002 journal article
BIVM, a Novel Gene Widely Distributed among Deuterostomes, Shares a Core Sequence with an Unusual Gene in Giardia lamblia
Genomics, 79(6), 750–755.
2002 journal article
Cloning novel immune-type inhibitory receptors from the rainbow trout, Oncorhynchus mykiss
Immunogenetics, 54(9), 662–670.
2002 review
Zebrafish as an immunological model system
[Review of ]. MICROBES AND INFECTION, 4(14), 1469–1478.
2001 journal article
Cloning and sequence analysis of a zebrafish cDNA encoding DNA (cytosine-5)-methyltransferase-1
GENESIS, 30(4), 213–219.
2001 journal article
Corrigendum to: “The zebrafish fth1, slc3a2, men1, pc, fgf3 and cycd1 genes define two regions of conserved synteny between linkage group 7 and human chromosome 11q13” [Gene 261 (2000) 235–242]
Gene, 269(1-2), 227.
2001 journal article
Extraordinary variation in a diversified family of immune-type receptor genes
Proceedings of the National Academy of Sciences, 98(24), 13832–13837.
2001 journal article
Immune-type receptor genes in zebrafish share genetic and functional properties with genes encoded by the mammalian leukocyte receptor cluster
Proceedings of the National Academy of Sciences, 98(12), 6771–6776.
2001 review
Novel immune-type receptor genes
[Review of ]. IMMUNOLOGICAL REVIEWS, 181(1), 250–259.
2001 journal article
Structure of human DNMT2, an enigmatic DNA methyltransferase homolog that displays denaturant-resistant binding to DNA
Nucleic Acids Research, 29(2), 439–448.
2000 chapter
Immune-Type Diversity in the Absence of Somatic Rearrangement
In Current Topics in Microbiology and Immunology (Vol. 248, pp. 271–282).
2000 journal article
The zebrafish fth1, slc3a2, men1, pc, fgf3 and cycd1 genes define two regions of conserved synteny between linkage group 7 and human chromosome 11q13
GENE, 261(2), 235–242.
1999 journal article
Cloning of two zebrafish cDNAs that share domains with the MHC class II-associated invariant chain
IMMUNOGENETICS, 50(1-2), 84–88.
1999 journal article
Expanding our understanding of immunoglobulin, T-cell antigen receptor, and novel immune-type receptor genes: A subset of the immunoglobulin gene superfamily
Immunogenetics, 50(3-4), 124–133. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033380849&partnerID=MN8TOARS
1999 review
Expanding our understanding of immunoglobulin, T-cell antigen receptor, and novel immune-type receptor genes: a subset of the immunoglobulin gene superfamily
[Review of ]. IMMUNOGENETICS, 50(3-4), 124–133.
1998 journal article
A candidate mammalian DNA methyltransferase related to pmt1p of fission yeast
Human Molecular Genetics, 7(2), 279–284.
1998 journal article
Sex-specific exons control DNA methyltransferase in mammalian germ cells
Development, 125(5), 889–897. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031889033&partnerID=MN8TOARS
1997 review
Cytosine methylation and the ecology of intragenomic parasites
[Review of ]. TRENDS IN GENETICS, 13(8), 335–340.
1997 journal article
DNA (cytosine-5)-methyltransferases in mouse cells and tissues. studies with a mechanism-based probe
Journal of Molecular Biology, 270(3), 385–395.
1996 journal article
Genetic analysis of genomic methylation patterns in plants and mammals
Biological Chemistry, 377(10), 605–610. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029998065&partnerID=MN8TOARS
1996 journal article
New 5′ Regions of the Murine and Human Genes for DNA (Cytosine-5)-methyltransferase
Journal of Biological Chemistry, 271(49), 31092–31097.
1991 journal article
Cross-linking a maturation-dependent ram sperm plasma membrane antigen induces the acrosome reaction
Molecular Reproduction and Development, 29(2), 200–207.
Updated: December 12th, 2020 13:35
2019 - present
2010 - 2019
2004 - 2010
2002 - 2004
1998 - 2002
Updated: July 3rd, 2015 12:56
1990 - 1997
1986 - 1990
Funding history based on the linked ORCID record. Updated: January 10th, 2022 17:34
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