Jeff Yoder
Also known as: Jeffrey Yoder. Jeffrey Alan Yoder
immunology, immunogenetics, immunotoxicology, genomics, DNA methylation, DNA methyltransferases
Dr. Jeff Yoder graduated from Worcester Polytechnic Institute with a B.S. in Biotechnology and performed his graduate work with Dr. Tim Bestor receiving his Ph.D. in Cell and Developmental Biology from Harvard University’s graduate program in Biological and Biomedical Sciences. He then did a post-doc with Dr. Gary Litman at the University of South Florida. Jeff was faculty at the University of South Florida before joined the faculty at NC State University in 2004. Jeff's current research interests are on identifying and characterizing novel mediators of innate immunity. His research employs the zebrafish model to study the genetic and functional evolution of innate immune receptors, for examining the immunotoxicological effects of environmental chemicals, and as a model for identifying novel mediators of immunity. His current studies on the evolution of immune receptors integrates genomic and transcriptomic data from all vertebrate lineages. His current immunotoxicology research employs zebrafish and cell culture models to study the impact of exposure to per- and polyfluoroalkyl substances (PFAS) on immune function. This research is highly interdisciplinary and includes collaborations with evolutionary biologists, structural biochemists, toxicologists, chemists, engineers and field biologists. His research has been funded by NIH, NIEHS, NSF, MAF, TriCEM and a variety of foundations and agencies.
Works (117)
Updated: December 24th, 2024 05:02
2024 journal article
Investigating the impact of whole genome duplication on transposable element evolution in teleost fishes
Genome Biology and Evolution.
Ed(s): A. Betancourt
Source: ORCID
Added: December 23, 2024
2024 journal article
Per- and polyfluoroalkyl substances alter innate immune function: evidence and data gaps
Journal of Immunotoxicology, 21(1).
Contributors: D. Phelps n , A. Connors n , G. Ferrero n, J. DeWitt n & n
author keywords: Per- and polyfluoroalkyl substances; PFAS; innate immunity; ecotoxicology; zebrafish; immunotoxicology
open access via www.tandfonline.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: May 8, 2024
2023 article
A chromosome-level genome assembly of longnose gar, Lepisosteus osseus
Mallik, R., Carlson, K. B., Wcisel, D. J., Fisk, M., Yoder, J. A., & Dornburg, A. (2023, April 29). (N. Whiteman, Ed.). G3-GENES GENOMES GENETICS, Vol. 4.
Ed(s): N. Whiteman
author keywords: teleost genome duplication; holostei; longnose gar; chromosome level assembly; living fossil; transposable elements
MeSH headings : Humans; Animals; Evolution, Molecular; Fishes / genetics; Genome; Chromosomes / genetics; Phylogeny
TL;DR:
The first high quality reference genome assembly and annotation of the longnose gar (Lepisosteus osseus) is reported, highlighting the potential utility of holostean genomes for understanding the evolution of vertebrate repetitive elements and providing a critical reference for comparative genomic studies utilizing ray-finned fish models.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 12, 2023
2023 article
Ancient Fish Lineages Illuminate Toll-Like Receptor Diversification in Early Vertebrate Evolution
Carlson, K. B., Nguyen, C., Wcisel, D. J., Yoder, J. A., & Dornburg, A. (2023, April 6).
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: April 7, 2023
2023 article
Ancient fish lineages illuminate toll-like receptor diversification in early vertebrate evolution
Carlson, K. B., Nguyen, C., Wcisel, D. J., Yoder, J. A., & Dornburg, A. (2023, August 9). IMMUNOGENETICS, Vol. 8.
author keywords: Vertebrate; TLR; Immunogenetics; Evolution; Actinopterygii; Polypterus senegalus
TL;DR:
This work investigates the diversification of vertebrate Toll-like receptors (TLRs), one of the most ancient and well conserved innate immune receptor families found across the Tree of Life, integrating genomic data that represent all major vertebrate lineages with new transcriptomic data from Polypteriformes, the earliest diverging ray-finned fish lineage.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 28, 2023
2023 journal article
Automated, high-throughput quantification of EGFP-expressing neutrophils in zebrafish by machine learning and a highly-parallelized microscope
PLOS ONE, 18(12).
TL;DR:
This open-source software package is presented which allows the user to train and evaluate a custom machine learning segmentation model and use it to localize zebrafish and analyze cell counts within the segmented region of interest.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 22, 2024
2023 article
Human DOCK11 Deficiency Causes Defective Erythropoiesis and Systemic Inflammation
Block, J., Rashkova, C., Castanon, I., Platon, J., Zoghi, S., Fujiwara, M., … Boztug, K. (2023, November 2). BLOOD, Vol. 142.
TL;DR:
It is found that human DOCK11 regulates T-cell morphology and migration, suggesting that defects in Docks11 might impact the T cells' capability to fight infections and the immune dysregulation observed in the patients was uncovered.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: March 4, 2024
2023 article
Investigating the impact of whole genome duplication on transposable element evolution in ray-finned fishes
Mallik, R., Wcisel, D. J., Near, T. J., Yoder, J. A., & Dornburg, A. (2023, December 23).
TL;DR:
The degree to which the teleost genome duplication (TGD) shaped the diversification trajectory of the ray-finned fish mobilome is investigated and the results suggest that historic ploidy events may not necessarily catalyze bursts of TE diversification and innovation.
(via Semantic Scholar)
Source: ORCID
Added: February 1, 2024
2023 journal article
Legacy and emerging per- and polyfluoroalkyl substances suppress the neutrophil respiratory burst
JOURNAL OF IMMUNOTOXICOLOGY, 20(1).
author keywords: Innate immunity; neutrophils; per- and polyfluoroalkyl substances (PFAS); reactive oxygen species; zebrafish
MeSH headings : Animals; Humans; Zebrafish; Neutrophils; Reactive Oxygen Species; Respiratory Burst; Fluorocarbons / toxicity; Alkanesulfonic Acids / toxicity; Environmental Pollutants
TL;DR:
This report is the first to demonstrate that these PFASs suppress neutrophil function and support the utility of employing zebrafish larvae and a human cell line as screening tools to identify chemicals that may suppress human immune function.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 15, 2023
2023 article
Systemic Inflammation and Normocytic Anemia in DOCK11 Deficiency
Block, J., Rashkova, C., Castanon, I., Zoghi, S., Platon, J., Ardy, R. C., … Boztug, K. (2023, June 21). NEW ENGLAND JOURNAL OF MEDICINE, Vol. 6.
TL;DR:
Germline hemizygous loss-of-function mutations affecting the actin regulator DOCK11 were shown to cause a previously unknown inborn error of hematopoiesis and immunity characterized by severe immune dysregulation and systemic inflammation, recurrent infections, and anemia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 7, 2023
2022 article
A chromosome level genome assembly of longnose gar,Lepisosteus osseus
Mallik, R., Carlson, K. B., Wcisel, D. J., Fisk, M., Yoder, J. A., & Dornburg, A. (2022, December 22).
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: December 23, 2022
2022 article
A highly diverse set of novel immunoglobulin-like transcript (NILT) genes in zebrafish indicates a wide range of functions with complex relationships to mammalian receptors
Wcisel, D. J., Dornburg, A., McConnell, S. C., Hernandez, K. M., Andrade, J., Jong, J. L. O., … Yoder, J. A. (2022, July 23). IMMUNOGENETICS, Vol. 7.
author keywords: Innate immunity; Gene content variation; Alternative immune haplotypes; Gene family evolution; Mammalian CD300 (CMRF35); Mammalian NCR2 (NKp44)
MeSH headings : Animals; Zebrafish / genetics; Amino Acid Sequence; Receptors, Immunologic / genetics; Genome / genetics; Immunoglobulins / genetics; Phylogeny; Mammals / genetics
TL;DR:
A higher level of genetic complexity, interindividual variation, and sequence diversity for NILTs than previously described is revealed, suggesting that this gene family likely plays multiple roles in host immunity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: July 23, 2022
2022 article
A highly diverse set of novel immunoglobulin-like transcript (NILT) genes in zebrafish indicates a wide range of functions with complex relationships to mammalian receptors
Wcisel, D. J., Dornburg, A., McConnell, S. C., Hernandez, K. M., Andrade, J., Jong, J. L. O., … Yoder, J. A. (2022, April 22). (Vol. 4). Vol. 4.
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: May 19, 2022
2022 journal article
Knockdown of Transmembrane Protein 150A (TMEM150A) Results in Increased Production of Multiple Cytokines
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 42(7), 336–342.
author keywords: cell signaling; interleukin-8; interleukin-6; RANTES; TMEM150A; TLR4
MeSH headings : Cell Line; Cytokines / metabolism; Lipopolysaccharides / pharmacology; Signal Transduction; Toll-Like Receptor 4 / metabolism
TL;DR:
Knockdown of TMEM150A in a lung epithelial cell line (H292) also led to increased cytokine levels in the unstimulated conditions suggesting TMEM 150A plays an important role in cellular homeostasis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: July 15, 2022
2022 article
On the relationship between extant innate immune receptors and the evolutionary origins of jawed vertebrate adaptive immunity
Dornburg, A., & Yoder, J. A. (2022, January 4). IMMUNOGENETICS, Vol. 74.
author keywords: Bowfin and gar (Holostei); Immune system evolution; Joining domains; Origins of V(D)J recombination; Zebrafish
MeSH headings : Adaptive Immunity / genetics; Animals; Evolution, Molecular; Immunity, Innate / genetics; Immunoglobulins / genetics; Phylogeny; Receptors, Antigen, T-Cell; Receptors, Immunologic / genetics; Vertebrates / genetics
TL;DR:
A conceptual model of the evolutionary origins and phylogenetic distribution of known VJ-containing innate immune receptors is provided, highlighting opportunities for future comparative research that are empowered by this emerging evolutionary perspective.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: January 4, 2022
2022 review
Placing human gene families into their evolutionary context
[Review of ]. HUMAN GENOMICS, 16(1).
MeSH headings : Animals; Humans; Evolution, Molecular; Genomics; Genome; Base Sequence; Phylogeny
TL;DR:
How homology can provide insights into the genes and gene families associated with immune response, cancer biology, vision, chemosensation, and metabolism, by revealing similarity in processes among distant species is shown.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 28, 2022
2022 article
Transcriptome annotation reveals minimal immunogenetic diversity among Wyoming toads, Anaxyrus baxteri
Carlson, K. B., Wcisel, D. J., Ackerman, H. D., Romanet, J., Christiansen, E. F., Niemuth, J. N., … Yoder, J. A. (2022, April 28). CONSERVATION GENETICS, Vol. 4.
author keywords: Amphibian; Bufonidae; Immunogenetics; MHC; TLR; Transcriptomics
TL;DR:
Comparison transcriptomics is used to examine the diversity of toll-like receptors and major histocompatibility complex sequences across three individual Wyoming toads and finds reduced diversity at MHC genes compared to bufonid species with a similar history of bottleneck events.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 29, 2022
2021 journal article
A Zebrafish Model of Metastatic Colonization Pinpoints Cellular Mechanisms of Circulating Tumor Cell Extravasation
FRONTIERS IN ONCOLOGY, 11.
author keywords: angiopellosis; circulating tumor cell cluster; tumor cell extravasation; cancer exodus hypothesis; metastasis; osteosarcoma
TL;DR:
Together, the results provide a novel experimental framework to study discrete steps in the metastatic process and identify the versican/ECM network dysregulation as a potential contributor to osteosarcoma circulating tumor cell metastasis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 26, 2021
2021 personal communication
From IgZ to IgT: A Call for a Common Nomenclature for Immunoglobulin Heavy Chain Genes of Ray-Finned Fish
Dornburg, A., Ota, T., Criscitiello, M. F., Salinas, I., Sunyer, J. O., Magadan, S., … Yoder, J. A. (2021, December 1).
MeSH headings : Animals; Fish Proteins / genetics; Fishes / genetics; Genes, Immunoglobulin Heavy Chain; Phylogeny; Terminology as Topic; Zebrafish / genetics
TL;DR:
Ray-finned fishes comprise more than half the *60,000 known vertebrate species, and are pivotal to the functionality of aquatic ecosystems and success of global multibillion dollar industries, necessitates that immunology and translational medicine research groups investigating the immune system in one or a number of species employ a common language for describing homologous immune components.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 10, 2022
2021 article
Holosteans contextualize the role of the teleost genome duplication in promoting the rise of evolutionary novelties in the ray-finned fish innate immune system
Dornburg, A., Wcisel, D. J., Zapfe, K., Ferraro, E., Roupe-Abrams, L., Thompson, A. W., … Yoder, J. A. (2021, June 11). (Vol. 6). Vol. 6.
Source: ORCID
Added: June 12, 2021
2021 journal article
Holosteans contextualize the role of the teleost genome duplication in promoting the rise of evolutionary novelties in the ray-finned fish innate immune system
Immunogenetics.
author keywords: Bowfin and gar; Multigene families; Diverse immunoglobulin domain-containing proteins (DICPs); Novel immune-type receptors (NITRs); V(D)J recombination; MHC
MeSH headings : Animals; Evolution, Molecular; Exons; Fish Proteins / genetics; Gene Duplication; Genetic Linkage; Genome; Immunity, Innate / genetics; Immunogenetics; Immunoglobulin Domains; Major Histocompatibility Complex / genetics; Multigene Family; Phylogeny; Skates, Fish / genetics; Skates, Fish / immunology; Transcriptome
TL;DR:
The receptor diversity of two clustered innate immune gene families in the teleost sister lineage: Holostei and gars is described and characterized, revealing an ancient linkage of DICPs to the major histocompatibility complex (MHC) and an evolutionary origin of NITR variable-joining exons that predate the TGD by at least 50 million years.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: September 13, 2021
2021 journal article
Single-minded 2 is required for left-right asymmetric stomach morphogenesis
DEVELOPMENT, 148(17).
author keywords: right asymmetry; Stomach; Morphogenesis; Pitx2; Sim2; Down syndrome; Frog
MeSH headings : Animals; Anura; Basic Helix-Loop-Helix Transcription Factors / genetics; Basic Helix-Loop-Helix Transcription Factors / metabolism; Body Patterning; Embryo, Nonmammalian; Endoderm / embryology; Endoderm / metabolism; Gene Expression Regulation, Developmental; Homeodomain Proteins / genetics; Homeodomain Proteins / metabolism; Morphogenesis; Stomach / embryology; Transcription Factors / genetics; Transcription Factors / metabolism
TL;DR:
It is demonstrated that sim2 functions downstream of LR patterning cues to regulate key cellular properties and behaviors in the left stomach epithelium that drive asymmetric curvature, and has implications for dose-dependent roles of laterality factors in non-laterality-related birth defects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 27, 2021
2021 article
The bowfin genome illuminates the developmental evolution of ray-finned fishes
Thompson, A. W., Hawkins, M. B., Parey, E., Wcisel, D. J., Ota, T., Kawasaki, K., … Braasch, I. (2021, August 30). NATURE GENETICS, Vol. 8.
MeSH headings : Animals; Biological Evolution; Chromatin / genetics; Evolution, Molecular; Fishes; Genome / genetics; Skates, Fish / genetics; Skates, Fish / immunology; Skates, Fish / physiology; Whole Genome Sequencing
TL;DR:
A chromosome-level genome assembly for bowfin is presented that enables gene-order analyses, settling long-debated neopterygian phylogenetic relationships and investigates the evolution of immune, scale, respiratory and fin skeletal systems and identifies hundreds of gene-regulatory loci conserved across vertebrates.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 7, 2021
2021 article
The evolution of innate immune receptors: investigating the diversity, distribution, and phylogeny of immune recognition across eukaryotes
Buckley, K. M., & Yoder, J. A. (2021, December 15). IMMUNOGENETICS, Vol. 74.
MeSH headings : Eukaryota; Evolution, Molecular; Immunity, Innate / genetics; Phylogeny; Receptors, Immunologic
TL;DR:
The diversity of IIRs from plants, vertebrates, invertebrate deuterostomes, a range of protostome invertebrates and basal metazoans is explored, and it is suggested that, to fully understand eukaryotic immune systems, further investigations of these proteins are warranted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: December 15, 2021
2020 journal article
In vivo assessment of respiratory burst inhibition by xenobiotic exposure using larval zebrafish
Journal of Immunotoxicology, 17(1), 94–104.
author keywords: Chemical screen; high throughput; phagocyte; reactive oxygen species (ROS); polycyclic aromatic hydrocarbons (PAH); endocrine disrupting compounds (EDC); lead
MeSH headings : Animals; Animals, Genetically Modified; Benzo(a)pyrene / adverse effects; Blood Cell Count; Cytotoxicity Tests, Immunologic / methods; Embryo, Nonmammalian; Estradiol / adverse effects; Feasibility Studies; High-Throughput Screening Assays / methods; Immunity, Innate / drug effects; Macrophages / drug effects; Macrophages / immunology; Methoxychlor / adverse effects; Neutrophils / drug effects; Neutrophils / immunology; Organometallic Compounds / adverse effects; Phenanthrenes / adverse effects; Reactive Oxygen Species / analysis; Reactive Oxygen Species / metabolism; Respiratory Burst / drug effects; Respiratory Burst / immunology; Zebrafish
TL;DR:
The utility of zebrafish larvae as a vertebrate model for identifying compounds that impact innate immune function at non-teratogenic levels is demonstrated and validates measuring ROS production and phagocyte numbers as metrics for monitoring how xenobiotic exposure alters the innate immune system.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: May 15, 2020
2020 journal article
Transcriptome Ortholog Alignment Sequence Tools (TOAST) for phylogenomic dataset assembly
BMC Evolutionary Biology, 20(1).
author keywords: BUSCO ortholog assembly; Cetacean and teleost fish phylogeny; Missing data visualization; Transcriptome; Concatenated alignment
MeSH headings : Animals; Datasets as Topic; Humans; Phylogeny; Sequence Alignment / methods; Software; Transcriptome
TL;DR:
ToAST is introduced, an open source R software package that can utilize the ortholog searches based on the software Benchmarking Universal Single-Copy Orthologs to assemble multiple sequence alignments of orthologous loci from transcriptomes for any group of organisms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Source: ORCID
Added: March 31, 2020
2019 journal article
Calcium imaging of primary canine sensory neurons: Small‐diameter neurons responsive to pruritogens and algogens
Brain and Behavior.
author keywords: dorsal laminectomy dissection; dorsal root ganglia cell culture; fura-2AM; ratiometric calcium imaging
MeSH headings : Animals; Cadaver; Calcium Radioisotopes; Capsaicin / pharmacology; Cattle; Cells, Cultured; Chloroquine / pharmacology; Dogs; Ganglia, Spinal / physiopathology; Histamine / pharmacology; Humans; Laminectomy; Molecular Imaging / methods; Neurotransmitter Agents / pharmacology; Pain / physiopathology; Peptide Fragments / pharmacology; Pruritus / chemically induced; Pruritus / physiopathology; Radiopharmaceuticals; Sensory Receptor Cells / physiology; Serotonin / pharmacology; Serotonin Receptor Agonists / pharmacology; Substance P / pharmacology
TL;DR:
Rodent primary sensory neurons are commonly used for studying itch and pain neurophysiology, but translation from rodents to larger mammals and humans is not direct and requires further validation to make correlations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: October 1, 2019
2019 chapter
Chapter 19 - Immunology
In The Zebrafish in Biomedical Research.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: December 20, 2019
2019 journal article
Circulating tumor cells exit circulation while maintaining multicellularity, augmenting metastatic potential.
Journal of Cell Science.
author keywords: Angiopellosis; Circulating tumor cell cluster; Tumor cell extravasation; Cancer exodus hypothesis; Metastasis
MeSH headings : Animals; Cell Count; Cell Movement / physiology; HeLa Cells; Humans; Mice; Neoplasm Metastasis; Neoplastic Cells, Circulating / metabolism
TL;DR:
Circulating tumor cell clusters spread throughout the body by using a unique method to exit blood vessels, which grants the tumor cells an increased ability to form secondary tumors.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: ORCID
Added: September 21, 2019
2019 journal article
Presence of cerebrospinal fluid antibodies associated with autoimmune encephalitis of humans in dogs with neurologic disease
Journal of Veterinary Internal Medicine, 33(5), 2175–2182.
author keywords: immunofluorescent assay; meningoencephalitis; MUE; NMDA receptor encephalitis
MeSH headings : Animals; Autoantibodies / cerebrospinal fluid; Central Nervous System Diseases / cerebrospinal fluid; Central Nervous System Diseases / immunology; Central Nervous System Diseases / veterinary; Dog Diseases / cerebrospinal fluid; Dog Diseases / immunology; Dogs; Female; Fluorescent Antibody Technique, Indirect / veterinary; Humans; Male; Meningoencephalitis / cerebrospinal fluid; Meningoencephalitis / immunology; Meningoencephalitis / therapy; Neurons / immunology; Receptors, N-Methyl-D-Aspartate / immunology
TL;DR:
Defining antigenic targets associated with encephalitis in dogs might allow diagnostic categorization of MUE antemortem and further evaluation of the prevalence and clinical relevance of CSF and serum antibodies to neuronal cell surface antigens is warranted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 9, 2019
2018 journal article
Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon
Journal of Biological Chemistry, 293(16), 6187–6200.
MeSH headings : Adaptor Proteins, Signal Transducing; Animals; Azepines / pharmacology; Cell Cycle Proteins; Cell Line, Tumor; Conserved Sequence; Cullin Proteins / metabolism; Humans; Immunologic Factors / metabolism; Immunologic Factors / pharmacology; Lenalidomide / pharmacology; Ligands; Mice; Molecular Probes; Nuclear Proteins / drug effects; Nuclear Proteins / metabolism; Peptide Hydrolases / chemistry; Peptide Hydrolases / metabolism; Proteasome Endopeptidase Complex / metabolism; Proteolysis; T-Lymphocytes / metabolism; Thalidomide / analogs & derivatives; Thalidomide / metabolism; Thalidomide / pharmacology; Transcription Factors / drug effects; Transcription Factors / metabolism; Triazoles / pharmacology; Ubiquitin / metabolism; Ubiquitin-Protein Ligases / metabolism
TL;DR:
It is shown that CRBN sequence variants retain their drug-binding properties to both classical immunomodulatory drugs and dBET1, a chemical compound and targeting ligand designed to degrade bromodomain-containing 4 via a CRBN-dependent mechanism, which provides a new understanding of CRBN's substrate-recruiting function.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: February 13, 2019
2018 journal article
Use of a specific polyclonal anti-canine TSLP antibody reveals TSLP expression in normal tissue and cell culture
Journal of Veterinary Pharmacology and Therapeutics, 41, 153–153.
Source: NC State University Libraries
Added: August 6, 2018
2017 journal article
BAC Recombineering of the Agouti Loci from Spotted Gar and Zebrafish Reveals the Evolutionary Ancestry of Dorsal–Ventral Pigment Asymmetry in Fish
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution.
TL;DR:
A dorsoventral-graded distribution of asip1 expression that is highest ventrally, similar to teleosts is demonstrated, providing evidence that the mechanism leading to an environmentally important pigment pattern was likely in place before the origin ofteleosts.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: February 1, 2024
2017 journal article
Disruption of Trim9 function abrogates macrophage motility in vivo
Journal of Leukocyte Biology, 102(6), 1371–1380.
author keywords: chemotaxis; zebrafish; leukocyte; ubiquitin
MeSH headings : Animals; Cell Movement / genetics; Cell Shape; Chemotaxis; Humans; Macrophages / cytology; Macrophages / metabolism; Nerve Tissue Proteins / genetics; Nerve Tissue Proteins / metabolism; RNA, Messenger / genetics; RNA, Messenger / metabolism; Tripartite Motif Proteins / genetics; Tripartite Motif Proteins / metabolism; U937 Cells; Ubiquitin-Protein Ligases / genetics; Ubiquitin-Protein Ligases / metabolism; Zebrafish / genetics; Zebrafish / immunology; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism
TL;DR:
It is demonstrated that Trim9 mediates cellular movement and migration in Mϕs as well as neurons, and is implicated in axonal migration, and found that M ϕ chemotaxis and cellular architecture are subsequently impaired in vivo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2017 journal article
Evolutionary divergence of the vertebrate TNFAIP8 gene family: Applying the spotted gar orthology bridge to understand ohnolog loss in teleosts
PLOS ONE, 12(6), e0179517.
Ed(s): P. Boudinot
TL;DR:
It is determined that teleost orthologs to human TNFAIP8 genes were likely lost in a genome inversion event after their divergence from their common ancestor with spotted gar, demonstrating the value of this enhanced approach to gene history analysis and support the development of teleost models to study complex questions related to an array of biomedical issues.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2017 journal article
Loss of DNA methylation in zebrafish embryos activates retrotransposons to trigger antiviral signaling
Development, 144(16), 2925–2939.
author keywords: Transposon; DNA methylation; Uhrf1; Interferon; Antiviral
MeSH headings : Animals; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases / genetics; DNA (Cytosine-5-)-Methyltransferases / metabolism; DNA Methylation / genetics; DNA Methylation / physiology; Retroelements / genetics; Signal Transduction / genetics; Signal Transduction / physiology; Trans-Activators / genetics; Trans-Activators / metabolism; Zebrafish / embryology; Zebrafish / metabolism; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism
TL;DR:
Activation of transposons in cells with global DNA hypomethylation mimics a viral infection by activating cytoplasmic DNA viral sensors suggests that antiviral pathways serve as surveillance of cells that have derepressed intragenomic parasites due to DNA hypometrichylations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2017 journal article
Spotted Gar and the Evolution of Innate Immune Receptors
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 328(7), 666–684.
MeSH headings : Amino Acid Sequence; Animals; Biological Evolution; Fishes / genetics; Fishes / immunology; Gene Expression Regulation / immunology; Immunity, Innate / genetics; Immunity, Innate / physiology
TL;DR:
It appears that both the total genome duplication and different patterns of genetic selection have influenced the derivation and stabilization of innate immune genes in a substantial manner during the course of vertebrate evolution.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2016 journal article
Alternative haplotypes of antigen processing genes in zebrafish diverged early in vertebrate evolution
Proceedings of the National Academy of Sciences, 113(34), E5014–E5023.
author keywords: comparative genomics; proteasome and TAP evolution; major histocompatibility; MHC class I pathway; CG2 clonal zebrafish
MeSH headings : Animals; Antigen Presentation; Biological Evolution; Cloning, Organism; Cysteine Endopeptidases / classification; Cysteine Endopeptidases / genetics; Cysteine Endopeptidases / immunology; Genome; Haplotypes; High-Throughput Nucleotide Sequencing; Histocompatibility Antigens Class I / classification; Histocompatibility Antigens Class I / genetics; Histocompatibility Antigens Class I / immunology; Phylogeny; Proteasome Endopeptidase Complex / genetics; Proteasome Endopeptidase Complex / immunology; Protein Isoforms / classification; Protein Isoforms / genetics; Protein Isoforms / immunology; Transcriptome; Zebrafish / classification; Zebrafish / genetics; Zebrafish / immunology; Zebrafish Proteins / classification; Zebrafish Proteins / genetics; Zebrafish Proteins / immunology
TL;DR:
Comparison analysis shows that antigen processing gene diversity is far more extensive than previously realized, implying distinct immune functions and conserved roles in shaping MHC pathway evolution throughout vertebrates.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2016 journal article
Angiopellosis as an Alternative Mechanism of Cell Extravasation
STEM CELLS, 35(1), 170–180.
author keywords: Extravasation; Angiopellosis; Transmigration; Stem cell infusion; Diapedesis
MeSH headings : Animals; Blood Vessels / physiology; CD11 Antigens / metabolism; Cell Aggregation; Cell Membrane / metabolism; Cell Shape; Dogs; Extravasation of Diagnostic and Therapeutic Materials / pathology; Female; Humans; Injections; Intravital Microscopy; Male; Mesenchymal Stem Cells; Microspheres; Myocytes, Cardiac / cytology; Polymers / chemistry; Rats; Time Factors; Transendothelial and Transepithelial Migration; Zebrafish / metabolism
TL;DR:
In injected cardiac and mesenchymal stem cells, the vascular wall undergoes an extensive remodeling to allow the cell to exit the lumen, while the injected cell remains distinctively passive in activity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2016 journal article
Erratum: Corrigendum: The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons
Nature Genetics, 48(6), 700–700.
TL;DR:
The draft spotted gar genome sequence is made publicly available, the assembly LepOcu1 publicly available from NCBI since 13 January 2012 under accession code GCA000242695.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: July 27, 2019
2016 journal article
Phage display and structural studies reveal plasticity in substrate specificity of caspase-3a from zebrafish
Protein Science, 25(11), 2076–2088.
Contributors: M. Tucker n, S. MacKenzie n, J. Maciag n, H. Dirscherl Ackerman, P. Swartz n, n , P. Hamilton n , A. Clay Clark *
author keywords: phage display substrate library; substrate recognition; Danio rerio; apoptosis
MeSH headings : Allosteric Regulation; Animals; Caspase 3 / chemistry; Crystallography, X-Ray; Molecular Dynamics Simulation; Peptide Library; Substrate Specificity; Zebrafish
TL;DR:
The structure of zebrafish Casp3a is determined to 2.28Å resolution by X‐ray crystallography, and the results suggest that a limited number of amino acid substitutions near the active site result in plasticity of the S4 sub‐site by increasing flexibility of one active site loop and by affecting hydrogen‐bonding with substrate.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Crossref, NC State University Libraries
Added: January 31, 2019
2016 review
Review of Automated Microinjection Systems for Single Cells in the Embryogenesis Stage
[Review of ]. IEEE-ASME TRANSACTIONS ON MECHATRONICS, 21(5), 2391–2404.
author keywords: Automation; biological cells; control system; mechatronics; reviews
TL;DR:
A comprehensive review of the major research technologies used in automated cell microin injection and of their individual subsystems concludes that research into automated microinjection systems will focus on reducing the scale of microinject systems and developing appropriate controllers.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2016 journal article
Single-cell transcriptional analysis of normal, aberrant, and malignant hematopoiesis in zebrafish
The Journal of Cell Biology, 213(3), 2133OIA95.
Sources: NC State University Libraries, ORCID, NC State University Libraries
Added: August 6, 2018
2016 journal article
Single-cell transcriptional analysis of normal, aberrant, and malignant hematopoiesis in zebrafish
The Journal of Experimental Medicine, 213(6), 979–992.
MeSH headings : Amino Acid Substitution; Animals; DNA-Binding Proteins / genetics; DNA-Binding Proteins / immunology; Hematopoiesis / genetics; Hematopoiesis / immunology; Hematopoietic Stem Cells / immunology; Hematopoietic Stem Cells / pathology; Killer Cells, Natural / immunology; Killer Cells, Natural / pathology; Mutation, Missense; Neoplastic Stem Cells / immunology; Neoplastic Stem Cells / pathology; Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma / immunology; Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology; T-Lymphocytes / immunology; T-Lymphocytes / pathology; Transcription, Genetic / genetics; Transcription, Genetic / immunology; Zebrafish / genetics; Zebrafish / immunology; Zebrafish Proteins / genetics; Zebrafish Proteins / immunology
TL;DR:
The first single-cell gene expression analysis in zebrafish blood is reported to distinguish major blood lineages, identify new cell types, and delineate heterogeneity in T cell leukemia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: July 27, 2019
2016 journal article
The confounding complexity of innate immune receptors within and between teleost species
Fish & Shellfish Immunology, 53, 24–34.
author keywords: Gene content haplotype; Novel immune-type receptors; Diverse immunoglobulin domain containing proteins; Polymeric immunoglobulin receptor-like proteins; Novel immunoglobulin-like transcripts
MeSH headings : Animals; Fishes / genetics; Fishes / immunology; Genetic Variation; Genome; Immunity, Innate; Receptors, Immunologic / genetics
TL;DR:
By defining which teleost lineages encode (and do not encode) different IIir families, predictions can be made about the presence (or absence) of specific IIIR families in each teleost lineage.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2016 journal article
The identification of additional zebrafish DICP genes reveals haplotype variation and linkage to MHC class I genes
Immunogenetics, 68(4), 295–312.
author keywords: Innate immunity; Immunoglobulin domain; Haplotype; Polymorphism; Immune receptor
MeSH headings : Animals; Gene Expression Regulation, Developmental; Genes, MHC Class I / genetics; Genes, MHC Class I / immunology; Genetic Linkage; Haplotypes; Immunity, Innate; Immunoglobulins / genetics; Lipids / genetics; Receptors, Immunologic / genetics; Receptors, Immunologic / immunology; Zebrafish / genetics; Zebrafish / growth & development; Zebrafish / immunology; Zebrafish Proteins / genetics; Zebrafish Proteins / immunology
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2016 journal article
The identification of additional zebrafish DICP genes reveals haplotype variation and linkage to MHC class I genes.
http://europepmc.org/abstract/med/26801775
Source: ORCID
Added: February 13, 2019
2016 journal article
The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons
Nature Genetics, 48(4), 427–437.
MeSH headings : Animals; Evolution, Molecular; Female; Fishes / genetics; Fishes / metabolism; Genome; Humans; Karyotype; Models, Genetic; Organ Specificity; Sequence Analysis, DNA; Transcriptome
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: NC State University Libraries, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2015 journal article
A nonclassical MHC class I U lineage locus in zebrafish with a null haplotypic variant
Immunogenetics, 67(9), 501–513.
author keywords: Teleost; MHC class I; Evolution; Polymorphism; Haplotype
MeSH headings : Amino Acid Sequence; Animals; Cell Line; Chromosome Mapping; Chromosome Walking; Evolution, Molecular; Female; Gene Expression Profiling; Genotype; Genotyping Techniques; Haplotypes / genetics; Histocompatibility Antigens Class I / classification; Histocompatibility Antigens Class I / genetics; Male; Molecular Sequence Data; Polymorphism, Genetic / genetics; Zebrafish / genetics; Zebrafish / immunology
TL;DR:
Two MHC class I U lineage genes are described that map to chromosome 22 in zebrafish and are likely to play a nonclassical role as they lack conservation of key peptide binding residues, display limited polymorphic variation, and exhibit tissue-specific expression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2015 journal article
Machine learning reveals sex-specific 17β-estradiol-responsive expression patterns in white perch (Morone americana) plasma proteins
PROTEOMICS, 15(15), 2678–2690.
Contributors: J. Schilling n, A. Nepomuceno n, A. Planchart n , n , R. Kelly n , D. Muddiman n , H. Daniels n, N. Hiramatsu*, B. Reading n
author keywords: Animal proteomics; Endocrine disrupting compounds; Machine learning; Plasma; Semiquantitative proteomics; Support vector machines
MeSH headings : Animals; Bass / metabolism; Blood Proteins / metabolism; Blotting, Western; Chromatography, Liquid; Estradiol / pharmacology; Estrogens / pharmacology; Female; Fish Proteins / metabolism; Kininogens / metabolism; Male; Nanotechnology / methods; Proteome / drug effects; Proteome / metabolism; Proteomics / methods; Sex Factors; Support Vector Machine; Tandem Mass Spectrometry; Vitellogenins / metabolism
TL;DR:
This is the first report that Eltd1 and Kng1 may be E2‐responsive proteins in fishes and therefore may be useful indicators of estrogen induction in fishes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2014 journal article
Differential expression and ligand binding indicate alternative functions for zebrafish polymeric immunoglobulin receptor (pIgR) and a family of pIgR-like (PIGRL) proteins
Immunogenetics, 66(4), 267–279.
author keywords: Teleost; Innate immunity; Lipid binding; Genome evolution
MeSH headings : Amino Acid Sequence; Animals; Chromosome Mapping; Conserved Sequence; Evolution, Molecular; Fishes / genetics; Fishes / immunology; Gene Expression; Humans; Immunity, Innate / genetics; Ligands; Mammals / genetics; Mammals / immunology; Molecular Sequence Data; Multigene Family; Phospholipids / metabolism; Phylogeny; Protein Binding; Protein Structure, Tertiary; Receptors, Polymeric Immunoglobulin / chemistry; Receptors, Polymeric Immunoglobulin / genetics; Receptors, Polymeric Immunoglobulin / metabolism; Rhabdoviridae Infections / genetics; Rhabdoviridae Infections / immunology; Rhabdoviridae Infections / metabolism; Sequence Homology, Amino Acid; Streptococcal Infections / genetics; Streptococcal Infections / immunology; Streptococcal Infections / metabolism; Zebrafish / genetics; Zebrafish / immunology; Zebrafish / metabolism; Zebrafish Proteins / genetics; Zebrafish Proteins / immunology; Zebrafish Proteins / metabolism
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2014 journal article
Multigene families of immunoglobulin domain-containing innate immune receptors in zebrafish: Deciphering the differences
Developmental & Comparative Immunology, 46(1), 24–34.
author keywords: Novel immune-type receptors; Diverse immunoglobulin domain containing proteins; Polymeric immunoglobulin receptor-like proteins; Novel immunoglobulin-like transcripts; Leukocyte immune-type receptors
MeSH headings : Animals; Haplotypes; Receptors, Immunologic / chemistry; Receptors, Immunologic / genetics; Receptors, Immunologic / immunology; Zebrafish / genetics; Zebrafish / immunology; Zebrafish Proteins / chemistry; Zebrafish Proteins / genetics; Zebrafish Proteins / immunology
TL;DR:
Five large multigene families encoding innate-type immune receptors that are comprised of immunoglobulin domains have been identified in bony fish, of which four do not possess definable mammalian orthologs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2014 journal article
Neutralization of Mitochondrial Superoxide by Superoxide Dismutase 2 Promotes Bacterial Clearance and Regulates Phagocyte Numbers in Zebrafish
Infection and Immunity, 83(1), 430–440.
Ed(s): B. McCormick
MeSH headings : Animals; Immunity, Innate; Leukocyte Count; Macrophages / enzymology; Macrophages / immunology; Mitochondria / enzymology; Mitochondria / metabolism; Pseudomonas aeruginosa / immunology; Superoxide Dismutase / metabolism; Superoxides / metabolism; Zebrafish
TL;DR:
The roles of SOD2 and mitochondrial ROS regulation in the zebrafish innate immune response to P. aeruginosa infection are described and the use of mitochondrion-targeted ROS scavengers as potential adjuvant therapies during severe infections is supported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2014 journal article
Preface to the Special Issue: Zebrafish immunity and infection models
Developmental & Comparative Immunology, 46(1), 1–2.
MeSH headings : Animals; Antigen-Presenting Cells / immunology; Infections / immunology; Mast Cells / immunology; Models, Animal; Zebrafish / genetics; Zebrafish / immunology
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2014 journal article
The MHC class I genes of zebrafish
Developmental & Comparative Immunology, 46(1), 11–23.
author keywords: Immunity; Multigene families; Haplotype; Polymorphism; Histocompatibility; MHC
MeSH headings : Animals; Genes, MHC Class I; Histocompatibility Antigens Class I / genetics; Histocompatibility Antigens Class I / immunology; Major Histocompatibility Complex; Phylogeny; Zebrafish / genetics; Zebrafish / immunology; Zebrafish Proteins / genetics; Zebrafish Proteins / immunology
TL;DR:
This review examines the polygenic, polymorphic, and haplotypic diversity of the zebrafish MHC class I genes, discussing known and postulated functional differences between the different class I lineages.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2013 journal article
A Semantic Model for Species Description Applied to the Ensign Wasps (Hymenoptera: Evaniidae) of New Caledonia
SYSTEMATIC BIOLOGY, 62(5), 639–659.
author keywords: Biodiversity informatics; Evaniidae; New Caledonia; new species; ontology; semantic phenotypes; semantic species description; taxonomy
MeSH headings : Animals; Classification / methods; Models, Biological; New Caledonia; Semantics; Species Specificity; Wasps / anatomy & histology; Wasps / classification
TL;DR:
A revision of the ensign wasp (Hymenoptera: Evaniidae) fauna of New Caledonia is presented using this new model for species description, and a foundation to discuss limitations and potential benefits such as automated data integration and reasoner-driven queries is provided.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2013 journal article
An ITAM in a Nonenveloped Virus Regulates Activation of NF- B, Induction of Beta Interferon, and Viral Spread
Journal of Virology, 88(5), 2572–2583.
MeSH headings : Amino Acid Sequence; Animals; Cell Line; Enzyme Activation; Humans; Immunoreceptor Tyrosine-Based Activation Motif; Interferon-beta / metabolism; Intracellular Signaling Peptides and Proteins / metabolism; Mice; Molecular Sequence Data; Myocytes, Cardiac / metabolism; Myocytes, Cardiac / virology; NF-kappa B / metabolism; Phosphorylation; Protein Binding; Protein-Tyrosine Kinases / metabolism; Reoviridae / pathogenicity; Reoviridae / physiology; Sequence Alignment; Syk Kinase; Tyrosine / metabolism; Viral Proteins / chemistry; Viral Proteins / metabolism; Viral Tropism
TL;DR:
It is demonstrated for the first time that μ2 is phosphorylated, contains a functional ITAM, and activates NF-κB, and the results suggest that the cell type-specific effect of the μ2 ITAM on viral spread reflects the celltype-specific effects of NF-β and IFN-β.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2013 journal article
Characterization of the Z lineage Major histocompatability complex class I genes in zebrafish
Immunogenetics, 66(3), 185–198.
author keywords: Teleost; MHC class I; Evolution; Polymorphism; Haplotype
MeSH headings : Alleles; Amino Acid Sequence; Animals; Chromosome Mapping; DNA, Complementary; Gene Expression; Gene Expression Regulation; Gene Order; Genes, MHC Class I; Genetic Linkage; Genetic Loci; Haplotypes; Molecular Sequence Data; Phylogeny; Polymorphism, Genetic; Sequence Alignment; Transcription, Genetic; Ubiquitination; Zebrafish / classification; Zebrafish / genetics; Zebrafish / immunology
TL;DR:
It is reported that neither of the Z transcripts previously described match the current genome assembly and these transcripts are classified as additional gene loci and a gene nomenclature system for the Z genes consistent with MHC nomenClature in other species and with the zebrafish gene nonymclature guidelines is presented.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2013 journal article
Super Resolution Microscopy Reveals that Caveolin-1 Is Required for Spatial Organization of CRFB1 and Subsequent Antiviral Signaling in Zebrafish
PLoS ONE, 8(7), e68759.
Ed(s): C. Lamaze
MeSH headings : Animals; Caveolin 1 / metabolism; Cell Membrane / metabolism; Disease Resistance / immunology; Fish Diseases / immunology; Fish Diseases / metabolism; Fish Diseases / virology; Immunity, Innate / genetics; Interferons / metabolism; Protein Binding; Receptors, Interferon / metabolism; Signal Transduction; Zebrafish / immunology; Zebrafish / metabolism; Zebrafish / virology; Zebrafish Proteins / metabolism
TL;DR:
This response strongly suggests that CRFB1 organization within cav-1b-containing membrane domains is critical for IFN-mediated antiviral defense and presents a previously undescribed antiviral evasion strategy to alter IFN signaling and the antiviral immune response.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2012 journal article
A Myristoylated Alanine-Rich C Kinase Substrate–Related Peptide Suppresses Cytokine mRNA and Protein Expression in LPS-Activated Canine Neutrophils
American Journal of Respiratory Cell and Molecular Biology, 48(3), 314–321.
author keywords: MARCKS; cytokine; inflammation; neutrophil
MeSH headings : Animals; Dogs; Humans; Interleukin-8 / biosynthesis; Interleukin-8 / genetics; Interleukin-8 / metabolism; Intracellular Signaling Peptides and Proteins / metabolism; Lipopolysaccharides / pharmacology; Membrane Proteins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; Neutrophils / drug effects; Neutrophils / metabolism; Peptides / metabolism; Peptides / pharmacology; RNA, Messenger / biosynthesis; RNA, Messenger / genetics; Tumor Necrosis Factor-alpha / biosynthesis; Tumor Necrosis Factor-alpha / genetics; Tumor Necrosis Factor-alpha / metabolism
TL;DR:
Observations identify MARCKS protein as a promising therapeutic target in the treatment of inflammatory diseases or syndromes attributed to neutrophil influx and inflammatory cytokine production, such as sepsis, acute lung injury, and acute respiratory distress syndrome.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2012 journal article
Development and Characterization of Anti-Nitr9 Antibodies
Advances in Hematology, 2012, 1–9.
TL;DR:
Anti-Nitr9 monoclonal antibodies were generated and evaluated for the ability to recognize the three Nitr9 isoforms and should prove to be useful for identifying the specific lymphocyte lineages that express Nitr9 and may permit the isolation of Nitr9-expressing cells that can be directly assessed for cytotoxic function.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: February 13, 2019
2012 journal article
Genomic and functional characterization of the diverse immunoglobulin domain-containing protein (DICP) family
Genomics, 99(5), 282–291.
author keywords: Zebrafish; Innate immunity; Lipid binding
MeSH headings : Alternative Splicing; Amino Acid Sequence; Animals; Binding Sites / genetics; Chromosome Mapping; Cloning, Molecular; DNA, Complementary / chemistry; DNA, Complementary / genetics; Genetic Variation; Genomics / methods; Immunoglobulins / chemistry; Immunoglobulins / genetics; Models, Molecular; Molecular Sequence Data; Multigene Family / genetics; Phospholipids / chemistry; Phospholipids / metabolism; Phylogeny; Protein Binding; Protein Isoforms / chemistry; Protein Isoforms / genetics; Protein Isoforms / metabolism; Protein Structure, Tertiary; Receptors, Immunologic / chemistry; Receptors, Immunologic / genetics; Receptors, Immunologic / metabolism; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Zebrafish / genetics; Zebrafish Proteins / chemistry; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism
TL;DR:
These findings suggest that novel multigene families encoding diversified immune receptors have arisen in different vertebrate lineages and affect parallel patterns of ligand recognition that potentially impact species-specific advantages.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2012 conference paper
Myristoylated Alanine-Rich C Kinase Substrate (MARCKS) Protein Plays A Critical Role In Production Of Proinflammatory Cytokines By Isolated Canine Neutrophils
A67. ACUTE LUNG INJURY AND ACUTE RESPIRATORY DISTRESS SYNDROME: BIOLOGICAL MECHANISMS.
Source: ORCID
Added: February 13, 2019
2012 journal article
Surface modifications on InAs decrease indium and arsenic leaching under physiological conditions
APPLIED SURFACE SCIENCE, 261, 842–850.
author keywords: InAs; Zebrafish; Toxicity; Passivation; Surface modifications; ICP-MS
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2011 journal article
A photoactivatable small-molecule inhibitor for light-controlled spatiotemporal regulation of Rho kinase in live embryos
Development, 139(2), 437–442.
author keywords: Small-molecule inhibitor; Rho kinase; Photocaging; Xenopus
MeSH headings : Animals; Body Patterning / drug effects; Dioxoles / metabolism; Dioxoles / pharmacology; Embryo, Nonmammalian / metabolism; Immunohistochemistry; Indoles / metabolism; Indoles / pharmacology; Mice; NIH 3T3 Cells; Pyridines / metabolism; Pyridines / pharmacology; Ultraviolet Rays; Xenopus laevis / embryology; Xenopus laevis / metabolism; rho-Associated Kinases / antagonists & inhibitors; rho-Associated Kinases / metabolism
TL;DR:
A novel pharmacological agent that can be light activated to achieve spatiotemporally limited inhibition of Rho kinase activity in vivo is developed and application to the spatially heterogeneous problem of embryonic left-right asymmetry revealed a differential requirement for Rho signaling on the left and right sides of the primitive gut tube.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2011 journal article
Expression and function of triggering receptor expressed on myeloid cells-1 (TREM-1) on canine neutrophils
Developmental & Comparative Immunology, 35(8), 872–880.
author keywords: TREM-1; TLR; Neutrophils; Sepsis; Canine
MeSH headings : Amino Acid Sequence; Animals; Cells, Cultured; Cloning, Molecular; Conserved Sequence; Cytokines / immunology; Cytokines / metabolism; Dogs / genetics; Dogs / immunology; Humans; Lipopolysaccharides / immunology; Lipopolysaccharides / pharmacology; Membrane Glycoproteins / genetics; Membrane Glycoproteins / immunology; Membrane Glycoproteins / metabolism; Molecular Sequence Data; Neutrophils / immunology; Neutrophils / metabolism; Phylogeny; Receptors, Immunologic / genetics; Receptors, Immunologic / metabolism; Sequence Alignment; Teichoic Acids / immunology; Teichoic Acids / pharmacology; Toll-Like Receptors / agonists; Up-Regulation / drug effects
TL;DR:
Functionally, canine TREM-1 synergistically enhances LPS-induced production of IL-8, TNF-α and a canine orthologue of CXCL1 and these data suggest that T REM-1 expression in dogs is an amplifier of pro-inflammatory responses to microbial products.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2011 journal article
Two Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Paralogs are Required for Normal Development in Zebrafish
The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology, 294(9), 1511–1524.
author keywords: MARCKS; zebrafish; development
MeSH headings : Amino Acid Sequence; Animals; Embryo, Nonmammalian / cytology; Embryo, Nonmammalian / metabolism; Intracellular Signaling Peptides and Proteins / antagonists & inhibitors; Intracellular Signaling Peptides and Proteins / genetics; Intracellular Signaling Peptides and Proteins / metabolism; Membrane Proteins / antagonists & inhibitors; Membrane Proteins / genetics; Membrane Proteins / metabolism; Molecular Sequence Data; Morpholinos / pharmacology; Multigene Family; Myristoylated Alanine-Rich C Kinase Substrate; Phenotype; Phylogeny; Sequence Homology, Amino Acid; Zebrafish / genetics; Zebrafish / growth & development
TL;DR:
It is demonstrated that Marcksa and Marcksb are required for normal zebrafish development and suggested that zebra fish are a suitable model to further study MARCKS function.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2010 journal article
Photocaged Morpholino Oligomers for the Light-Regulation of Gene Function in Zebrafish and Xenopus Embryos
Journal of the American Chemical Society, 132(44), 15644–15650.
MeSH headings : Animals; Cells, Cultured; Embryo, Nonmammalian / metabolism; Gene Expression; Morpholines / chemistry; Oligonucleotides / genetics; Oligonucleotides / metabolism; Ultraviolet Rays; Xenopus laevis / genetics; Xenopus laevis / metabolism; Zebrafish / genetics; Zebrafish / metabolism
TL;DR:
A novel and efficient synthetic route for incorporating photocaged monomeric building blocks directly into morpholino oligomers is reported and the utility of these caged morpholinos in the light-activated control of gene function in both cell culture and living embryos is demonstrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2010 journal article
Specific Resistance to Pseudomonas aeruginosa Infection in Zebrafish Is Mediated by the Cystic Fibrosis Transmembrane Conductance Regulator
Infection and Immunity, 78(11), 4542–4550.
MeSH headings : Animals; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Cystic Fibrosis Transmembrane Conductance Regulator / genetics; Cystic Fibrosis Transmembrane Conductance Regulator / metabolism; Disease Models, Animal; Humans; Immunity, Innate; Neutrophils / immunology; Pseudomonas Infections / immunology; Pseudomonas Infections / microbiology; Pseudomonas aeruginosa / genetics; Pseudomonas aeruginosa / metabolism; Pseudomonas aeruginosa / pathogenicity; Quorum Sensing; Trans-Activators / genetics; Trans-Activators / metabolism; Virulence; Zebrafish / immunology; Zebrafish / microbiology
TL;DR:
The zebrafish system provides a multitude of advantages for studying the pathogenesis of P. aeruginosa and for understanding the role that innate immune cells, such as neutrophils, play in the host response to acute bacterial infections commonly associated with cystic fibrosis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2010 journal article
The phylogenetic origins of natural killer receptors and recognition: relationships, possibilities, and realities
Immunogenetics, 63(3), 123–141.
author keywords: Marsupial; Monotreme; Chicken; Xenopus; Zebrafish; Innate immunity; Cytotoxicity
MeSH headings : Animals; Evolution, Molecular; Humans; Immunity, Innate; Killer Cells, Natural / immunology; Mammals / genetics; Mammals / immunology; Phylogeny; Receptors, Natural Killer Cell / genetics; Receptors, Natural Killer Cell / immunology; Receptors, Natural Killer Cell / metabolism; Vertebrates / genetics; Vertebrates / immunology
TL;DR:
Several lines of evidence suggest that NK-type function or its equivalent has sustained a long evolutionary history throughout vertebrate species and likely reflects the influence of pathogens on their evolution.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2009 journal article
Developmental and tissue-specific expression of NITRs
Immunogenetics, 62(2), 117–122.
author keywords: Innate immunity; Lymphocytes; Natural killer receptors
MeSH headings : Animals; Embryo, Nonmammalian / metabolism; Female; Gene Expression Regulation, Developmental; Organ Specificity; Ovary / metabolism; Receptors, Immunologic / genetics; Receptors, Immunologic / immunology; Zebrafish / embryology; Zebrafish / genetics; Zebrafish / immunology; Zebrafish / metabolism; Zebrafish Proteins / genetics; Zebrafish Proteins / immunology
TL;DR:
The expression of multiple NITR genes in the zebrafish ovary and during embryogenesis is demonstrated and all 14 families of NITRs are shown to be expressed in the lymphocyte lineage, but not in the myeloid lineage, consistent with the hypothesis that N ITRs function as NKRs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2009 journal article
Enhanced transcription of complement and coagulation genes in the absence of adaptive immunity
Molecular Immunology, 46(7), 1505–1516.
author keywords: Zebrafish; Mouse; rag1; Innate immunity; SCID
MeSH headings : Adaptation, Physiological / genetics; Adaptation, Physiological / immunology; Animals; Animals, Genetically Modified; Blood Coagulation Factors / genetics; Blood Coagulation Factors / metabolism; Complement C4 / genetics; Complement C4 / metabolism; Complement System Proteins / genetics; Complement System Proteins / metabolism; Female; Gene Expression Profiling; Genes, RAG-1 / physiology; Immunity / genetics; Immunity / physiology; Intestinal Mucosa / metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oligonucleotide Array Sequence Analysis; Transcription, Genetic; Up-Regulation; Zebrafish
TL;DR:
It is hypothesized that the rag1(-/-) zebrafish may possess an "enhanced" innate immune response to compensate for the lack of an adaptive immune system.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2009 journal article
Sp2 Is a Maternally Inherited Transcription Factor Required for Embryonic Development
Journal of Biological Chemistry, 285(6), 4153–4164.
MeSH headings : Amino Acid Sequence; Animals; COS Cells; Chlorocebus aethiops; Chromosome Mapping; Embryo, Mammalian / embryology; Embryo, Mammalian / metabolism; Female; Gene Expression Regulation, Developmental; Green Fluorescent Proteins / genetics; Green Fluorescent Proteins / metabolism; Humans; In Situ Hybridization; Male; Mice; Microscopy, Fluorescence; Molecular Sequence Data; Phylogeny; Promoter Regions, Genetic / genetics; RNA, Messenger, Stored / genetics; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Sp2 Transcription Factor / classification; Sp2 Transcription Factor / genetics; Sp2 Transcription Factor / metabolism; Synteny; Transcription, Genetic; Zebrafish / embryology; Zebrafish / genetics; Zebrafish / growth & development; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism
TL;DR:
The role(s) played by Sp2 in early metazoan development is addressed by cloned and characterized Sp2 from zebrafish, and the intron/exon organization and amino acid sequence of Sp2 is closely conserved with its mammalian orthologues.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Crossref, NC State University Libraries, Web Of Science
Added: August 6, 2018
2008 journal article
A critical role for DAP10 and DAP12 in CD8+ T cell-mediated tissue damage in large granular lymphocyte leukemia
Blood, 113(14), 3226–3234.
MeSH headings : Adaptor Proteins, Signal Transducing / genetics; Adaptor Proteins, Signal Transducing / metabolism; Adaptor Proteins, Signal Transducing / physiology; CD28 Antigens / metabolism; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / metabolism; CD8-Positive T-Lymphocytes / pathology; Cytotoxicity, Immunologic / genetics; Endothelial Cells / immunology; Endothelial Cells / pathology; Extracellular Signal-Regulated MAP Kinases / metabolism; Humans; K562 Cells; Leukemia, Large Granular Lymphocytic / genetics; Leukemia, Large Granular Lymphocytic / immunology; Leukemia, Large Granular Lymphocytic / metabolism; Leukemia, Large Granular Lymphocytic / pathology; Membrane Proteins / genetics; Membrane Proteins / metabolism; Membrane Proteins / physiology; Phosphatidylinositol 3-Kinases / metabolism; Pulmonary Artery / immunology; Pulmonary Artery / pathology; Receptors, Immunologic / genetics; Receptors, Immunologic / metabolism; Receptors, Immunologic / physiology; Receptors, Natural Killer Cell / metabolism; Signal Transduction / genetics; Tumor Cells, Cultured
TL;DR:
Results shown suggest that inhibitors of DAP10 and DAP12 or other proteins involved in this signaling pathway will be attractive therapeutic targets for the treatment of LGLL and other autoimmune diseases and syndromes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2008 journal article
Aquatic animal models of human disease: Selected papers and recommendations from the 4th Conference
Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 149(2), 121–128.
MeSH headings : Animals; Disease Models, Animal; Fishes; Humans; Mollusca
TL;DR:
Of increasing importance are contributions of aquatic invertebrates and fishes to the detection of toxic responses from: metal mining and smelting impacts, polycyclic aromatichydrocarbons and persistent organic pollutants and their adverse effects in harbors and coastal estuaries, including the verification of remediation processes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2008 journal article
Assessing infection and immunity in zebrafish
Zebrafish, 5(3), 189–191.
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: February 13, 2019
2008 journal article
Clinical improvement by farnesyltransferase inhibition in NK large granular lymphocyte leukemia associated with imbalanced NK receptor signaling
Blood, 112(12), 4694–4698.
MeSH headings : Antineoplastic Agents / therapeutic use; Cells, Cultured; Enzyme Inhibitors / therapeutic use; Farnesyltranstransferase / antagonists & inhibitors; Female; Humans; Hypertension, Pulmonary / drug therapy; Hypertension, Pulmonary / etiology; K562 Cells; Leukemia, Large Granular Lymphocytic / complications; Leukemia, Large Granular Lymphocytic / drug therapy; Leukemia, Large Granular Lymphocytic / genetics; Middle Aged; Quinolones / therapeutic use; Receptors, Natural Killer Cell / genetics; Signal Transduction / genetics; Treatment Outcome
TL;DR:
A genetic approach demonstrated that killing of pulmonary endothelial cells by patient NK cells was mediated by dysregulated balance in activating and inhibitory NK-receptor signaling, and suggested a causal relationship between the expanded lymphocyte population and these clinical manifestations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2008 journal article
Evidence for a transposition event in a second NITR gene cluster in zebrafish
Immunogenetics, 60(5), 257–265.
author keywords: multigene family; cytogenetics; retrotransposition
MeSH headings : Amino Acid Sequence; Animals; Gene Duplication; Molecular Sequence Data; Multigene Family; Phylogeny; Receptors, Immunologic / genetics; Receptors, Immunologic / metabolism; Zebrafish / genetics; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism
TL;DR:
Phylogenetic analyses indicate that the V domains encoded by the nitr13 and nitr14 genes are more similar to each other than any other zebrafish NITR suggesting that these genes arose from a tandem gene duplication event.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2008 journal article
Form, function and phylogenetics of NITRs in bony fish
Developmental & Comparative Immunology, 33(2), 135–144.
author keywords: Teleost; Innate immunity; Natural killer receptors; ITIM; ITSM; DAP12; CD8; KIR
MeSH headings : Animals; DNA, Complementary / genetics; Fishes / genetics; Fishes / immunology; Humans; Immunoglobulins / immunology; Ligands; Phylogeny; Receptors, Immunologic / chemistry; Receptors, Immunologic / genetics; Receptors, Immunologic / immunology
TL;DR:
An analysis of all published NITRs demonstrates the conserved nature of multiple residues within the NITR Ig domains permitting the identification of NITr ESTs from salmon, cod, halibut, lake whitefish and stickleback species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2008 journal article
Gene Silencing in Mammalian Cells with Light-Activated Antisense Agents
ChemBioChem, 9(18), 2937–2940.
author keywords: Antisense agents; caged compounds; DNA; gene regulation; RNA
MeSH headings : Animals; Base Sequence; Gene Silencing; Genes, Reporter; Light; Luciferases, Renilla / chemistry; Mice; NIH 3T3 Cells; Oligonucleotides, Antisense / chemistry; Oligonucleotides, Antisense / metabolism; Oligonucleotides, Antisense / radiation effects; Phosphorothioate Oligonucleotides / chemistry; Phosphorothioate Oligonucleotides / metabolism; Transfection
TL;DR:
Detailed knowledge of the external regulation of gene func-tion is a fundamental necessity in order to annotate sequencedgenomes and to understand biological processes in single cells and multicellular organisms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2008 journal article
Light-activation of gene function in mammalian cells via ribozymes
Chem. Commun., (5), 568–570.
MeSH headings : Cell Line; Gene Expression / radiation effects; Humans; RNA, Catalytic / chemistry; RNA, Catalytic / metabolism; RNA, Messenger / metabolism; Toyocamycin / chemistry; Toyocamycin / radiation effects; Ultraviolet Rays
TL;DR:
A ribozyme based gene control element enabled the spatio-temporal regulation of gene function in mammalian cell culture with light.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2008 journal article
The medaka novel immune-type receptor (NITR) gene clusters reveal an extraordinary degree of divergence in variable domains
BMC Evolutionary Biology, 8(1), 177.
MeSH headings : Amino Acid Sequence; Animals; Conserved Sequence; Evolution, Molecular; Fish Proteins / genetics; Fish Proteins / immunology; Genetic Variation; Immunoglobulin Variable Region / genetics; Models, Genetic; Molecular Sequence Data; Multigene Family; Oryzias / genetics; Phylogeny; Protein Structure, Tertiary / genetics; Receptors, Immunologic / genetics; Species Specificity; Synteny; Zebrafish / genetics; Zebrafish / immunology
TL;DR:
Comprehensive phylogenetic analyses between the complete datasets of NITRs from medaka and zebrafish indicate multiple species-specific expansions of different families of NITS, consistent with recent birth-and-death events.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2008 journal article
Workshop report - assessing infection and immunity in zebrafish
Zebrafish, 5, 189–191.
Source: NC State University Libraries
Added: August 6, 2018
2007 article
Immunoglobulin variable regions in molecules exhibiting characteristics of innate and adaptive immune receptors
IMMUNOLOGIC RESEARCH, Vol. 38, pp. 294–304.
MeSH headings : Animals; Chitin / chemistry; Fishes / immunology; Immunity, Innate; Immunoglobulin Variable Region / chemistry; Immunoglobulin Variable Region / classification; Phylogeny; Protein Structure, Tertiary; Receptors, Immunologic / chemistry; Receptors, Immunologic / classification
TL;DR:
The laboratory has discovered two families of molecules, the novel immune-type receptors and the variable region-containing chitin-binding proteins, that share some characteristics of adaptive immune receptors but likely mediate innate functions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2007 journal article
Structural characteristics of zebrafish orthologs of adaptor molecules that associate with transmembrane immune receptors
Gene, 401(1-2), 154–164.
author keywords: DAP10; DAP12; FcR gamma; CD3 zeta
MeSH headings : Adaptor Proteins, Signal Transducing / chemistry; Adaptor Proteins, Signal Transducing / genetics; Adaptor Proteins, Signal Transducing / metabolism; Amino Acid Sequence; Animals; CD3 Complex / genetics; CD3 Complex / metabolism; Cell Lineage; Cell Membrane / immunology; Cell Membrane / metabolism; Cloning, Molecular; DNA, Complementary; Embryo, Nonmammalian; Gene Expression Regulation, Developmental; Genome; Killer Cells, Natural / immunology; Molecular Sequence Data; Phylogeny; Protein Structure, Tertiary; Receptors, IgG / immunology; Receptors, Immunologic / chemistry; Receptors, Immunologic / genetics; Receptors, Immunologic / metabolism; Receptors, KIR; Sequence Homology, Amino Acid; Zebrafish / embryology; Zebrafish / genetics; Zebrafish Proteins
TL;DR:
In an effort to understand developmental aspects of immune receptor function, the partially annotated zebrafish genome is accessed to identify six different adaptor molecules that are homologous to those effecting immune function in mammals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2007 journal article
The zebrafish activating immune receptor Nitr9 signals via Dap12
Immunogenetics, 59(10), 813–821.
author keywords: natural cytotoxicity; DAP10; ERK; AKT; DAP12; NITR
MeSH headings : Adaptor Proteins, Signal Transducing / genetics; Adaptor Proteins, Signal Transducing / immunology; Adaptor Proteins, Signal Transducing / metabolism; Amino Acid Sequence; Animals; Cell Line; Humans; Molecular Sequence Data; Phosphorylation; Receptors, KIR / genetics; Receptors, KIR / immunology; Receptors, KIR / metabolism; Recombinant Proteins / immunology; Recombinant Proteins / metabolism; Sequence Alignment; Signal Transduction / immunology; Zebrafish; Zebrafish Proteins / genetics; Zebrafish Proteins / immunology; Zebrafish Proteins / metabolism
TL;DR:
Cross-linking the Nitr9L–Dap12 complex results in activation of the phosphytidylinositol 3-kinase→AKT→extracellular signal-regulated kinase pathway suggesting that the DAP12-based activating pathway is conserved between bony fish and mammals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2006 journal article
Conditional Transgene and Gene Targeting Methodologies in Zebrafish
Zebrafish, 3(4), 415–429.
TL;DR:
The focus of this review is to summarize the pros and cons of the currently available systems for functional genomics in zebrafish, and to discuss the need for future methodologies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, NC State University Libraries, Crossref, NC State University Libraries
Added: August 6, 2018
2006 journal article
Immune-related, lectin-like receptors are differentially expressed in the myeloid and lymphoid lineages of zebrafish
Immunogenetics, 58(1), 31–40.
author keywords: C-type lectin; ITIM; natural killer cells; signaling motifs
MeSH headings : Amino Acid Sequence; Animals; Cell Survival / physiology; Chromosomes; Chromosomes, Artificial, Bacterial; Killer Cells, Natural / metabolism; Lectins, C-Type / chemistry; Lectins, C-Type / genetics; Lectins, C-Type / metabolism; Lectins, C-Type / physiology; Lymphocytes / metabolism; Models, Molecular; Molecular Sequence Data; Myeloid Cells / metabolism; Phylogeny; Zebrafish / genetics; Zebrafish / immunology; Zebrafish / metabolism; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism
TL;DR:
A multi-gene family of Group II immune-related, lectin-like receptors (illrs) whose members possess inhibiting and/or activating signaling motifs typical of Group V NK receptors are identified.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2006 journal article
Methylation of tRNAAsp by the DNA Methyltransferase Homolog Dnmt2
Science, 311(5759), 395–398.
MeSH headings : Animals; Anticodon; Arabidopsis / genetics; Arabidopsis / physiology; Arabidopsis Proteins / genetics; Catalytic Domain; Cytosine / metabolism; DNA (Cytosine-5-)-Methyltransferases / chemistry; DNA (Cytosine-5-)-Methyltransferases / genetics; DNA (Cytosine-5-)-Methyltransferases / metabolism; Drosophila Proteins / genetics; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Evolution, Molecular; Humans; Mass Spectrometry; Methylation; Mice; Mutation; NIH 3T3 Cells; RNA, Plant / metabolism; RNA, Transfer, Asp / chemistry; RNA, Transfer, Asp / metabolism; Transfection
TL;DR:
The sequence and the structure of DNA methyltransferase-2 (DnMT2) bear close affinities to authentic DNA cytosine methyltransferases, and human DNMT2 protein restored methylation in vitro to tRNAAsp from Dnmt2-deficient strains of mouse, Arabidopsis thaliana, and Drosophila melanogaster in a manner that was dependent on preexisting patterns of modified nucleosides.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2006 journal article
Role for retinoid signaling in left–right asymmetric digestive organ morphogenesis
Developmental Dynamics, 235(8), 2266–2275.
author keywords: retinoic acid; RALDH2; CYP26A1; gut; looping; malrotation; Xenopus; biliary atresia; annular pancreas
MeSH headings : Aldehyde Dehydrogenase 1 Family; Aldehyde Oxidase / genetics; Animals; Body Patterning; Cytochrome P-450 Enzyme System / genetics; Digestive System / growth & development; Digestive System / metabolism; Morphogenesis; Oxidoreductases / genetics; Receptors, Retinoic Acid / metabolism; Retinal Dehydrogenase; Retinoic Acid 4-Hydroxylase; Retinoids / metabolism; Signal Transduction; Xenopus Proteins / genetics; Xenopus laevis / genetics; Xenopus laevis / growth & development; Xenopus laevis / metabolism
TL;DR:
It is shown that the genes for retinaldehyde dehydrogenase and a retinoic acid hydroxylase are expressed in complementary patterns in the Xenopus gut during looping, likely to play a critical role in asymmetric gut tube morphogenesis and may underlie the etiology of several clinically relevant defects in the digestive system.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2004 journal article
Investigating the morphology, function and genetics of cytotoxic cells in bony fish
Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 138(3), 271–280.
author keywords: C-type lectin; cytotoxicity; cytotoxic T lymphocyte; macrophage; natural killer cell; neutrophil; non-specific cytotoxic cells; novel immune-type receptors
MeSH headings : Animals; Cytotoxicity, Immunologic / immunology; Fishes / genetics; Fishes / immunology; Humans; Killer Cells, Natural / cytology; Killer Cells, Natural / immunology; Killer Cells, Natural / metabolism; Macrophages / cytology; Macrophages / immunology; Neutrophils / cytology; Neutrophils / immunology; T-Lymphocytes, Cytotoxic / cytology; T-Lymphocytes, Cytotoxic / immunology
TL;DR:
The novel immune-type receptors (NITR) and cichlid killer leukocyte receptors (cKLR) that are structurally related to mammalian NK receptors and likely play a role in cytotoxic function in fish are identified.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2004 journal article
On the origins of adaptive immunity:possible clues from the SIRP and NITR multigene families
Trends in Immunology, 25, 11–16.
Source: NC State University Libraries
Added: August 6, 2018
2004 journal article
Resolution of the novel immune-type receptor gene cluster in zebrafish
Proceedings of the National Academy of Sciences, 101(44), 15706–15711.
MeSH headings : Alleles; Alternative Splicing; Amino Acid Sequence; Animals; Chromosome Mapping; DNA, Complementary / genetics; Evolution, Molecular; Genetic Variation; Lectins, C-Type / chemistry; Lectins, C-Type / genetics; Models, Molecular; Molecular Sequence Data; Multigene Family; Phylogeny; Protein Structure, Tertiary; Receptors, Immunologic / chemistry; Receptors, Immunologic / genetics; Zebrafish / genetics; Zebrafish / immunology; Zebrafish Proteins / chemistry; Zebrafish Proteins / genetics; Zebrafish Proteins / immunology
TL;DR:
It is indicated that the NITRs represent the most complex family of activating/inhibitory surface receptors thus far described in zebrafish, and high-confidence modeling of Nitr V-domain structures reveals a significant shift in the spatial orientation of the Ig fold, in the region of highest interfamily variation, compared with Ig V domains.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2003 journal article
Novel Immune-type Receptor Genes and the Origins of Adaptive and Innate Immune Recognition
Integrative and Comparative Biology, 43(2), 331–337.
TL;DR:
These studies indicate that leukocyte regulatory receptors, including those that mediate natural killer function, might have emerged early in vertebrate evolution and that the NITR/ITR genes represent a new and potentially highly significant link between innate and adaptive immune responses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2003 journal article
On the origins of adaptive immunity: Innate immune receptors join the tale
Trends in Immunology, 25(1), 11–16.
MeSH headings : Amino Acid Sequence; Animals; Antigens, Differentiation; Evolution, Molecular; Humans; Immunoglobulins / immunology; Membrane Glycoproteins / immunology; Multigene Family; Neural Cell Adhesion Molecule L1 / immunology; Receptors, Antigen; Receptors, Antigen, T-Cell / immunology; Receptors, Immunologic; Sequence Homology, Amino Acid
TL;DR:
The existence of an evolutionary and functional link between innate and adaptive immune receptors that sheds light on the nature of the antigen receptor predecessor(s) is proposed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: February 13, 2019
2003 article
The Zebrafish as a Model Organism to Study Development of the Immune System
Advances in Immunology, Vol. 81, pp. 254–330.
TL;DR:
Establishing the zebrafish as a model system for the study of the immune system will provide an alternative and complementary tool to the use of forward genetic screens in mice.
(via Semantic Scholar)
Sources: NC State University Libraries, ORCID, NC State University Libraries
Added: August 6, 2018
2002 journal article
BIVM, a Novel Gene Widely Distributed among Deuterostomes, Shares a Core Sequence with an Unusual Gene in Giardia lamblia
Genomics, 79(6), 750–755.
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Chromosome Mapping; Chromosomes, Human, Pair 13; Conserved Sequence; Gene Transfer, Horizontal; Genome, Human; Giardia lamblia / genetics; Humans; Immunoglobulins / genetics; Mice; Molecular Sequence Data; Organ Specificity; Protozoan Proteins; Vertebrates / genetics
TL;DR:
Characterization of BIVM in representative species demonstrates significant conservation throughout deuterostomes; however, an unusual gene has been identified in the protozoan pathogen Giardia lamblia that is similar to the core sequence of B IVM, suggesting the possibility of a horizontal gene transfer.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2002 journal article
Cloning novel immune-type inhibitory receptors from the rainbow trout, Oncorhynchus mykiss
Immunogenetics, 54(9), 662–670.
TL;DR:
A comprehensive, phylogenetic analysis of NITRs from rainbow trout and three other major lineages of bony fish defines conserved families of N ITRs and suggests an ancient lineage of distinct groups of genes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2002 review
Zebrafish as an immunological model system
[Review of ]. MICROBES AND INFECTION, 4(14), 1469–1478.
author keywords: mutation screens; zebrafish genome project; transgenesis; developmental immunology; novel immune-type genes
MeSH headings : Animals; Fish Diseases / immunology; Immunity, Active / genetics; Immunity, Innate / physiology; Killer Cells, Natural / immunology; Models, Animal; Models, Immunological; Mutagenesis; Transgenes; Zebrafish / genetics; Zebrafish / immunology
TL;DR:
Two decades of research have established the zebrafish as a significant model system for studying vertebrate development and gene structure-function relationships and recent advances in mutation screening, the creation of genomic resources, and the development of efficient transgenesis procedures make this model increasingly attractive for immunological study.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2001 journal article
Cloning and sequence analysis of a zebrafish cDNA encoding DNA (cytosine-5)-methyltransferase-1
GENESIS, 30(4), 213–219.
author keywords: DNA cytosine-5-methyltransferase; DNA mtase; Dnmt1; zebrafish; methylation; development
MeSH headings : Amino Acid Motifs; Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases / chemistry; DNA (Cytosine-5-)-Methyltransferases / genetics; DNA, Complementary / genetics; Molecular Sequence Data; Open Reading Frames / genetics; Polymerase Chain Reaction; Sequence Homology; Zebrafish / genetics; Zebrafish Proteins / chemistry; Zebrafish Proteins / genetics
TL;DR:
The determination of the full‐length cDNA sequence corresponding to the zebrafish DNA (cytosine‐5‐) methyltransferase gene, Dnmt1, is 4,907 bases long and has an open reading frame predicted to encode a 1,499 amino acid protein that is similar in size and sequence to a number of other methyltransferases identified in other organisms.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2001 journal article
Corrigendum to: “The zebrafish fth1, slc3a2, men1, pc, fgf3 and cycd1 genes define two regions of conserved synteny between linkage group 7 and human chromosome 11q13” [Gene 261 (2000) 235–242]
Gene, 269(1-2), 227.
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: February 13, 2019
2001 journal article
Extraordinary variation in a diversified family of immune-type receptor genes
Proceedings of the National Academy of Sciences, 98(24), 13832–13837.
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; DNA, Complementary; Evolution, Molecular; Gene Expression; Genetic Variation; Ictaluridae; Immunoglobulin Variable Region / classification; Immunoglobulin Variable Region / genetics; Lymphocyte Culture Test, Mixed; Molecular Sequence Data; Receptors, Immunologic / classification; Receptors, Immunologic / genetics
TL;DR:
Eleven related genes encoding distinct structural forms have been identified in Ictalurus punctatus (channel catfish), a well characterized immunological model system that represents a third independent bony fish lineage.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2001 journal article
Immune-type receptor genes in zebrafish share genetic and functional properties with genes encoded by the mammalian leukocyte receptor cluster
Proceedings of the National Academy of Sciences, 98(12), 6771–6776.
MeSH headings : Amino Acid Sequence; Animals; Biological Evolution; Conserved Sequence; Genes, Immunoglobulin; Genetic Linkage; Killer Cells, Natural / immunology; Molecular Sequence Data; Multigene Family; Receptors, Immunologic / genetics; Zebrafish / genetics; Zebrafish / immunology
TL;DR:
Antibody-induced crosslinking of Nitrs that have been introduced into a human natural killer cell line inhibits the phosphorylation of mitogen-activated protein kinase that is triggered by natural killer-sensitive tumor target cells.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2001 review
Novel immune-type receptor genes
[Review of ]. IMMUNOLOGICAL REVIEWS, 181(1), 250–259.
MeSH headings : Animals; Biological Evolution; Fishes / genetics; Fishes / immunology; Genetic Variation; Genome; Models, Biological; Molecular Structure; Polymerase Chain Reaction; Receptors, Immunologic / chemistry; Receptors, Immunologic / genetics
TL;DR:
The presence in NITR of V regions that are related closely to those found in Ig and TCR, as well as regulatory motifs and other structural features that are characteristic of immune inhibitory receptors encoded at the leukocyte receptor cluster, suggests that the NITRs are representative of an integral stage in the evolution of innate and adaptive immune function.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2001 journal article
Structure of human DNMT2, an enigmatic DNA methyltransferase homolog that displays denaturant-resistant binding to DNA
Nucleic Acids Research, 29(2), 439–448.
MeSH headings : Adenosine Triphosphate / chemistry; Amino Acid Motifs; Amino Acid Sequence; Animals; Binding Sites; Computer Simulation; Conserved Sequence; Crystallography, X-Ray; DNA (Cytosine-5-)-Methyltransferases / chemistry; DNA (Cytosine-5-)-Methyltransferases / genetics; Guanosine Triphosphate / chemistry; Humans; Mice; Models, Molecular; Molecular Sequence Data; Multigene Family; Nucleic Acid Denaturation; Protein Denaturation; Protein Structure, Quaternary; Protein Structure, Secondary; Protein Structure, Tertiary; Recombinant Proteins / chemistry; Sequence Deletion; Sequence Homology, Amino Acid
TL;DR:
It is shown that homologs of DNMT2, which are present in some organisms that are not known to methylate their genomes, contain a specific target-recognizing sequence motif including an invariant CysPheThr tripeptide.
(via Semantic Scholar)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2000 chapter
Immune-Type Diversity in the Absence of Somatic Rearrangement
In Current Topics in Microbiology and Immunology (Vol. 248, pp. 271–282).
MeSH headings : Animals; Antibody Diversity; Biological Evolution; Fishes / genetics; Fishes / immunology; Gene Rearrangement; Genes, Immunoglobulin
TL;DR:
The possibility that immune-type diversity is achieved in the absence of somatic rearrangement and that remnants of such systems could be operative in immune recognition in contemporary vertebrates is of extraordinary significance in terms of the authors' overall understanding of the relationships between adaptive and innate immune recognition.
(via Semantic Scholar)
Sources: NC State University Libraries, ORCID, NC State University Libraries
Added: August 6, 2018
2000 journal article
The zebrafish fth1, slc3a2, men1, pc, fgf3 and cycd1 genes define two regions of conserved synteny between linkage group 7 and human chromosome 11q13
GENE, 261(2), 235–242.
author keywords: T51 radiation hybrid panel; LN54 radiation hybrid panel; hlx1; DBX; prkri; cd81
MeSH headings : Amino Acid Sequence; Animals; Antigens, CD / genetics; Carrier Proteins / genetics; Chromosome Mapping; Chromosomes, Human, Pair 11 / genetics; Conserved Sequence; Expressed Sequence Tags; Ferritins / genetics; Fusion Regulatory Protein-1; Genes / genetics; HSP40 Heat-Shock Proteins; Homeodomain Proteins / genetics; Humans; Membrane Proteins; Molecular Sequence Data; Protein Serine-Threonine Kinases / antagonists & inhibitors; Pyruvate Carboxylase / genetics; Radiation Hybrid Mapping; Repressor Proteins / genetics; Sequence Alignment; Sequence Homology, Amino Acid; Tetraspanin 28; Zebrafish / genetics
TL;DR:
Six full-length zebrafish cDNAs, fth1, slc3a2, prkri, cd81, and pc, as well as one putative human gene, DBX were identified and their map positions ascertained, defining two regions of conserved synteny between linkage group 7 and 11q13.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1999 journal article
Cloning of two zebrafish cDNAs that share domains with the MHC class II-associated invariant chain
IMMUNOGENETICS, 50(1-2), 84–88.
author keywords: Iclp-1; Iclp-2; MHC class II; invariant chain; thyroglobulin type-1 repeat; zebrafish
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1999 journal article
Expanding our understanding of immunoglobulin, T-cell antigen receptor, and novel immune-type receptor genes: A subset of the immunoglobulin gene superfamily
Immunogenetics, 50(3-4), 124–133. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033380849&partnerID=MN8TOARS
Source: ORCID
Added: February 13, 2019
1999 review
Expanding our understanding of immunoglobulin, T-cell antigen receptor, and novel immune-type receptor genes: a subset of the immunoglobulin gene superfamily
[Review of ]. IMMUNOGENETICS, 50(3-4), 124–133.
author keywords: DNA sequencing; electronic PCR; EST database; short-primer PCR
MeSH headings : Amino Acid Sequence; Animals; Humans; Immunoglobulins / genetics; Molecular Sequence Data; Multigene Family / genetics; Receptors, Antigen, T-Cell / genetics; Receptors, Immunologic / genetics; Sequence Alignment; Sequence Homology, Amino Acid
TL;DR:
A technique termed the short-primer polymerase chain reaction (PCR) that targets structurally conserved short motifs in the Ig fold is developed to explore whether there are additional structurally related but otherwise distinct members of this subset of the immunoglobulin superfamily.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
1998 journal article
A candidate mammalian DNA methyltransferase related to pmt1p of fission yeast
Human Molecular Genetics, 7(2), 279–284.
MeSH headings : 5-Methylcytosine; Amino Acid Sequence; Animals; Bacterial Proteins / chemistry; Chromosome Mapping; Chromosomes, Human, Pair 10 / genetics; Cytosine / analogs & derivatives; Cytosine / analysis; DNA (Cytosine-5-)-Methyltransferases / chemistry; DNA (Cytosine-5-)-Methyltransferases / genetics; DNA (Cytosine-5-)-Methyltransferases / isolation & purification; DNA Methylation; DNA, Complementary / genetics; Evolution, Molecular; Fetal Proteins / chemistry; Fetal Proteins / genetics; Fetal Proteins / isolation & purification; Fungal Proteins / chemistry; Fungal Proteins / genetics; Gene Expression; Gene Targeting; Humans; Isoenzymes / chemistry; Isoenzymes / genetics; Isoenzymes / isolation & purification; Mice / embryology; Mice / genetics; Molecular Sequence Data; Schizosaccharomyces / enzymology; Schizosaccharomyces / genetics; Sequence Alignment; Sequence Homology, Amino Acid; Species Specificity; Stem Cells / enzymology
TL;DR:
Dnmt2 is a candidate for the activity that methylates newly integrated retroviral DNA and maintains trace levels of 5-methylcytosine in the DNA of embryonic stem cells homozygous for null mutations in Dnmt1, the gene for the one previously recognized metazoan DNA methyltransferase.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
1998 journal article
Sex-specific exons control DNA methyltransferase in mammalian germ cells
Development, 125(5), 889–897. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031889033&partnerID=MN8TOARS
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
1997 review
Cytosine methylation and the ecology of intragenomic parasites
[Review of ]. TRENDS IN GENETICS, 13(8), 335–340.
MeSH headings : Animals; Cytosine / metabolism; DNA Methylation; DNA Transposable Elements; Gametogenesis; Gene Expression Regulation, Developmental; Mammals / genetics; Neoplasms / genetics; Retroviridae / genetics
TL;DR:
It has become increasingly difficult to hold that reversible promoter methylation is commonly involved in developmental gene control; instead, suppression of parasitic sequence elements appears to be the primary function of cytosine methylation, with crucial secondary roles in allele-specific gene expression as seen in X inactivation and genomic imprinting.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1997 journal article
DNA (cytosine-5)-methyltransferases in mouse cells and tissues. studies with a mechanism-based probe
Journal of Molecular Biology, 270(3), 385–395.
author keywords: DNA (cytosine-5)-methyltransferases; 5-fluoro 2'-deoxycytidine; mammalian development; mechanism-based inhibitors; 5-methylcytosine
MeSH headings : Amino Acid Sequence; Animals; DNA / genetics; DNA / metabolism; DNA (Cytosine-5-)-Methyltransferases / metabolism; DNA Methylation; Deoxycytidine / analogs & derivatives; Embryonic and Fetal Development; Humans; Leukemia, Erythroblastic, Acute; Mice; Molecular Probe Techniques; Molecular Sequence Data; Oligodeoxyribonucleotides; Stem Cells / enzymology; Substrate Specificity; Tumor Cells, Cultured; Zinc / metabolism
TL;DR:
Data suggest that any sequence-specific de novo methylation mediated by Dnmt1 is either under the control of regulatory factors that interact with DnMT1, or is cued by alternative secondary structures in DNA.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
1996 journal article
Genetic analysis of genomic methylation patterns in plants and mammals
Biological Chemistry, 377(10), 605–610. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029998065&partnerID=MN8TOARS
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
1996 journal article
New 5′ Regions of the Murine and Human Genes for DNA (Cytosine-5)-methyltransferase
Journal of Biological Chemistry, 271(49), 31092–31097.
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Chickens; Codon; DNA (Cytosine-5-)-Methyltransferases / genetics; Exons; Humans; Mice; Molecular Sequence Data; RNA, Messenger / chemistry; Ribonuclease H / metabolism; Sea Urchins; Sequence Alignment
TL;DR:
Characterization of mRNA 5′ sequences and the intron-exon structure of the 5′ region of the murine and human genes indicated that a previously described promoter element actually lies in an intron that is more than 5 kilobases downstream of the transcription start sites.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
1991 journal article
Cross-linking a maturation-dependent ram sperm plasma membrane antigen induces the acrosome reaction
Molecular Reproduction and Development, 29(2), 200–207.
author keywords: FERTILIZATION; PROTEOLIPID; EXOCYTOSIS; CAPPING
MeSH headings : Acrosome / physiology; Animals; Antigen-Antibody Reactions; Bacterial Toxins / metabolism; Calcimycin / pharmacology; Calcium; Cell Membrane / immunology; Immunologic Capping; Male; Microscopy, Electron; Pertussis Toxin; Pore Forming Cytotoxic Proteins; Sialoglycoproteins / immunology; Sialoglycoproteins / physiology; Sperm Head / immunology; Sperm Head / physiology; Spermatozoa; Virulence Factors, Bordetella / pharmacology
TL;DR:
It is shown that induction of the acrosome reaction with Ca2+ ionophore causes ESA152 to be redistributed from the posterior to the anterior region of the head plasma membrane.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
Employment
Updated: October 14th, 2024 20:18
2024 - present
North Carolina State University Raleigh, US
Professor
Department of Biology
2024 - present
North Carolina State University Raleigh, US
Executive Director
Genetics and Genomics Academy
2019 - 2024
NC State University Raleigh, NC, US
Professor
Department of Molecular Biomedical Sciences
2010 - 2019
North Carolina State University Raleigh, NC, US
Associate Professor
Department of Molecular Biomedical Sciences
2004 - 2010
North Carolina State University Raleigh, NC, US
Assistant Professor
Department of Molecular Biomedical Sciences
2002 - 2004
University of South Florida Tampa, FL, US
Assistant Professor
Department of Biology
1998 - 2002
University of South Florida St. Petersburg, FL, US
Postdoctoral fellow
Department of Pediatrics
Education
Updated: July 3rd, 2015 12:56
1990 - 1997
Harvard University Cambridge, MA, US
Ph.D.
Cell and Developmental Biology
1986 - 1990
Worcester Polytechnic Institute Worcester, MA, US
B.S.
Biology and Biotechnology
Funding History
Funding history based on the linked ORCID record. Updated: October 14th, 2024 20:19
grant
August 1, 2024 - July 31, 2027
Collaborative Research: OSIB: A Multi-Omic Evaluation of Innate Immune Responses Across Vertebrate Evolution
Directorate for Biological Sciences
grant
August 16, 2021 - July 31, 2023
Linking PFAS exposure to thyroid disruption and innate immunity
National Institute of Environmental Health Sciences
grant
July 1, 2021 - May 1, 2023
Parallelized Imaging and Automated Analysis of Zebrafish Assays with a Gigapixel Microscope
Office of the Director
grant
February 28, 2020 - January 31, 2025
Center for Environmental and Health Effects of PFAS
National Institute of Environmental Health Sciences
grant
April 1, 2018 - March 31, 2021
Collaborative Research: Understanding the molecular diversification of self recognition through ray-finned fish innate immune receptor families
Directorate for Biological Sciences
grant
April 1, 2017 - March 31, 2018
Conference: From Omics to Function, Future Directions for Comparative Immunology, NACI Workshop, June 12-15, 2017, Raleigh, North Carolina
Directorate for Biological Sciences
contract
September 1, 2014 - September 1, 2016
Zebrafish immune function and disease resistance assays
National Institute of Environmental Health Sciences
grant
June 15, 2008 - November 30, 2010
Whole organism transcriptional profiling of innate immune response
National Institute of Allergy and Infectious Diseases
grant
December 1, 2004 - July 1, 2015
Novel Innate Immune Receptors in Zebrafish
National Institutes of Health
grant
April 5, 2004 - March 31, 2007
Novel Immune-Type Receptors and Cytotoxicity In Zebrafish
National Science Foundation - Directorate for Biological Sciences
grant
August 1, 1999 - January 1, 2001
NOVEL IMMUNE TYPE RECEPTOR (NITR) GENES IN ZEBRAFISH
National Institute of General Medical Sciences
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