Works (15)
Updated: July 28th, 2023 21:14
2012 journal article
Ceruloplasmin alters intracellular iron regulated proteins and pathways: Ferritin, transferrin receptor, glutamate and hypoxia-inducible factor-1α
Experimental Eye Research, 97(1), 90–97.
author keywords: ceruloplasmin; iron; lens epithelial cells; retinal pigmented epithelial cells glutamate; hypoxia-inducible factor; transferrin receptor; ferritin
MeSH headings : Animals; Cells, Cultured; Ceruloplasmin / metabolism; Ceruloplasmin / pharmacology; Dogs; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Ferritins / metabolism; Fluorescent Antibody Technique, Indirect; Glutamic Acid / metabolism; Hypoxia-Inducible Factor 1, alpha Subunit / metabolism; Iron Chelating Agents / pharmacology; Lens, Crystalline / cytology; Oxalates / pharmacology; Receptors, Transferrin / metabolism; Retinal Pigment Epithelium / drug effects; Retinal Pigment Epithelium / metabolism
TL;DR:
The Cp increased production and secretion of the neurotransmitter, glutamate, is a substantive finding of clinical relevance because of the neural and retinal degeneration found in aceruloplasminemia patients.
(via Semantic Scholar)
open access via europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref
Added: August 6, 2018
2010 journal article
Altered Ferritin Subunit Composition: Change in Iron Metabolism in Lens Epithelial Cells and Downstream Effects on Glutathione Levels and VEGF Secretion
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 51(9), 4437–4446.
MeSH headings : Animals; Apoferritins / genetics; Apoferritins / metabolism; Cell Nucleus / metabolism; Cells, Cultured; Culture Media, Conditioned / pharmacology; Cystine / pharmacokinetics; Dogs; Epithelial Cells / cytology; Epithelial Cells / metabolism; Glutathione / metabolism; Homeostasis / physiology; Hypoxia-Inducible Factor 1, alpha Subunit / metabolism; Iron / metabolism; Lens, Crystalline / cytology; Lens, Crystalline / metabolism; Oxidative Stress / physiology; Protein Subunits / genetics; Protein Subunits / metabolism; RNA, Small Interfering; Transfection; Vascular Endothelial Growth Factor A / metabolism
TL;DR:
Iron storage in ferritin was greatly reduced by FHsiRNA, resulting in increased iron availability, as noted by a decrease in transferrin receptor levels and iron uptake from transferrin, and profound effects clearly demonstrate that maintenance of a specific H:L ratio is part of a basic cellular homeostatic mechanism.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Iron metabolism in the eye: A review
Experimental Eye Research, 88(2), 204–215.
author keywords: iron; ferritin; transferrin; lens; retinal pigmented epithelium; retina
MeSH headings : Animals; Eye / metabolism; Eye Diseases / metabolism; Homeostasis; Humans; Iron / metabolism; Oxidative Stress; Signal Transduction / physiology
TL;DR:
This review article covers all aspects of iron metabolism, which include studies of iron levels within the eye and the processes used to maintain normal levels of iron in ocular tissues.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref
Added: August 6, 2018
2008 journal article
Iron regulates L-cystine uptake and glutathione levels in lens epithelial and retinal pigment epithelial cells by its effect on cytosolic aconitase
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 49(1), 310–319.
MeSH headings : 2,2'-Dipyridyl / pharmacology; Aconitate Hydratase / antagonists & inhibitors; Aconitate Hydratase / metabolism; Amino Acid Transport System y+ / genetics; Amino Acid Transport System y+ / metabolism; Animals; Cells, Cultured; Chelating Agents / pharmacology; Cystine / metabolism; Cytosol; Dogs; Enzyme Inhibitors / pharmacology; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Fluorescent Antibody Technique, Indirect; Gene Expression; Glutathione / metabolism; Immunoblotting; Lens, Crystalline / drug effects; Lens, Crystalline / metabolism; Oxalates / pharmacology; Pigment Epithelium of Eye / metabolism; RNA, Messenger / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Transferrin / pharmacology
TL;DR:
The authors found that the iron-induced increase in L-glutamate availability increased L-cystine uptake, with subsequent increases in GSH levels, demonstrating for the first time that iron regulates L-cycline uptake and the downstream production of GSH in two mammalian cell types.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Iron alters glutamate secretion by regulating cytosolic aconitase activity
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 288(5), C1117–C1124.
author keywords: retinal pigment epithelial cells; lens epithelial cells
MeSH headings : Aconitate Hydratase / antagonists & inhibitors; Aconitate Hydratase / metabolism; Animals; Cells, Cultured; Citric Acid / metabolism; Cytosol / metabolism; Dogs; Enzyme Activation / drug effects; Glutamates / metabolism; Iron / metabolism; Isocitrates / metabolism; Membrane Transport Proteins / metabolism; Oxalates / pharmacology; Pigment Epithelium of Eye / drug effects; Pigment Epithelium of Eye / enzymology; Riluzole / pharmacology; Vesicular Glutamate Transport Protein 1
TL;DR:
The results are the first to provide a functional link between these two physiologically important substances by demonstrating a significant role for iron in the regulation of glutamate production and secretion in mammalian cells resulting from iron regulation of aconitase activity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Rabbit pigmented ciliary epithelium produces interleukin-6 in response to inflammatory cytokines
EXPERIMENTAL EYE RESEARCH, 70(3), 271–279.
author keywords: interleukin-6; pigmented ciliary epithelium; interleukin-1; tumor necrosis factor-alpha; adenosine 3 ',5 '-cyclic monophosphate
MeSH headings : Animals; Cell Culture Techniques; Ciliary Body / immunology; Ciliary Body / metabolism; Cyclic AMP / metabolism; Cytokines / immunology; Endotoxins / immunology; Interleukin-1 / immunology; Interleukin-6 / biosynthesis; Pigment Epithelium of Eye / immunology; Pigment Epithelium of Eye / metabolism; Rabbits; Tumor Necrosis Factor-alpha / immunology
TL;DR:
The results indicate that the pigmented ciliary epithelium is one potential source of interleukin-6 and may contribute to the elevation in intraocular fluid interleucin- 6 levels observed during various intraocular inflammatory episodes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1996 journal article
Interleukin-1 beta increases prostaglandin E(2)-stimulated adenosine 3',5'-cyclic monophosphate production in rabbit pigmented ciliary epithelium
EXPERIMENTAL EYE RESEARCH, 63(1), 91–104.
author keywords: ciliary epithelium; cyclic AMP, interleukin-1; prostaglandins; transforming growth factor-beta; pigmented ciliary epithelium
MeSH headings : Animals; Cells, Cultured; Colforsin / pharmacology; Cyclic AMP / biosynthesis; Cycloheximide / pharmacology; Cyclooxygenase Inhibitors / pharmacology; Dinoprostone / pharmacology; Dose-Response Relationship, Drug; Indomethacin / pharmacology; Interleukin-1 / pharmacology; Isoproterenol / pharmacology; Kinetics; Lipopolysaccharides / pharmacology; Pigment Epithelium of Eye / drug effects; Pigment Epithelium of Eye / metabolism; Protein Synthesis Inhibitors / pharmacology; Rabbits; Stimulation, Chemical; Transforming Growth Factor beta / pharmacology; Tumor Necrosis Factor-alpha / pharmacology; Up-Regulation; Vasoactive Intestinal Peptide / pharmacology
TL;DR:
This is the first report of prostaglandin E2-induced stimulation of adenosine 3',5'-cyclic monophosphate production by pigmented ciliary epithelial cells and of the unique ability of interleukin-1 to increase this effect.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1996 journal article
Nitric oxide synthase inhibitors exert differential time-dependent effects on LPS-induced uveitis
EXPERIMENTAL EYE RESEARCH, 62(1), 21–28.
author keywords: nitric oxide; uveitis; nitric oxide synthase; nitric oxide synthase inhibitors; inflammation
MeSH headings : Animals; Aqueous Humor / metabolism; Arginine / analogs & derivatives; Arginine / therapeutic use; Cell Count / drug effects; Dose-Response Relationship, Drug; Eye Proteins / drug effects; Guanidines / therapeutic use; Kinetics; Lipopolysaccharides; NG-Nitroarginine Methyl Ester; Nitric Oxide / antagonists & inhibitors; Nitric Oxide / physiology; Nitric Oxide Synthase / antagonists & inhibitors; Rabbits; Uveitis, Anterior / etiology; Uveitis, Anterior / metabolism; Uveitis, Anterior / prevention & control
TL;DR:
Investigation of the effects of NOS inhibitors with different NOS isoform specificities in the rabbit model of endotoxin-induced ocular inflammation suggests that cNOS may play a greater role in the earlier stages of this developing inflammatory response, and extends others' observations that NO is a key mediator in uveitis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1995 journal article
INFLAMMATION-INDUCED CHANGES IN ADENOSINE 3',5'-CYCLIC-MONOPHOSPHATE PRODUCTION BY CILIARY EPITHELIAL-CELL BILAYERS
EXPERIMENTAL EYE RESEARCH, 60(2), 165–171.
author keywords: ADENOSINE 3',5'-CYCLIC MONOPHOSPHATE; INTERLEUKIN-1; TUMOR NECROSIS FACTOR; ANTERIOR UVEA; CILIARY EPITHELIUM; ENDOTOXIN; UVEITIS
MeSH headings : Animals; Ciliary Body / drug effects; Ciliary Body / metabolism; Colforsin / pharmacology; Culture Techniques; Cyclic AMP / biosynthesis; Epithelium / drug effects; Epithelium / metabolism; Interleukin-1 / pharmacology; Isoproterenol / pharmacology; Lipopolysaccharides / pharmacology; Male; Rabbits; Recombinant Proteins / pharmacology; Tumor Necrosis Factor-alpha / pharmacology; Uveitis, Anterior / etiology; Uveitis, Anterior / metabolism
TL;DR:
The inability of IL-1 beta, TNF alpha, or the low concentration of endotoxin to increase cAMP production by bilayers, in vitro, suggests that the enhanced cAMPProduction observed with inflamed bilayer, ex vivo, was not due to a direct action of these inflammatory agonists on the ciliary epithelial bilayer.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1995 journal article
MEDIATORS OF THE OCULAR INFLAMMATORY RESPONSE TO INTERLEUKIN-1-BETA PLUS TUMOR-NECROSIS-FACTOR-ALPHA
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 233(2), 94–100.
MeSH headings : Animals; Indomethacin / therapeutic use; Interleukin-1 / toxicity; Male; Platelet Activating Factor / antagonists & inhibitors; Platelet Activating Factor / metabolism; Rabbits; Tumor Necrosis Factor-alpha / toxicity; Uveitis, Anterior / immunology; Uveitis, Anterior / prevention & control; Uveitis, Posterior / immunology; Uveitis, Posterior / prevention & control
TL;DR:
The findings do not support an important role for PAF in TNFa/IL-1β-induced uveitis, and it cannot be ruled out that more intensive treatment with a specific and long-acting PAF-receptor antagonist might yield more positive results.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1992 journal article
Effects of copper loading and depletion on rabbit superoxide dismutase activity
Trace Elements in Medicine, 9, 55–58.
Source: NC State University Libraries
Added: August 6, 2018
1992 journal article
Synergistic uveitic effects of tumor necrosis factor-alpha and interleukin-1 beta
Investigative Ophthalmology and Visual Science, 33, 2120–2127.
Source: NC State University Libraries
Added: August 6, 2018
1991 journal article
Lipid mediators of TNF- induced uveitis
Investigative Ophthalmology and Visual Science, 32, 2393–2399.
Source: NC State University Libraries
Added: August 6, 2018
1990 journal article
OCULAR INFLAMMATORY EFFECTS OF INTRAVITREALLY INJECTED TUMOR NECROSIS FACTOR-ALPHA AND ENDOTOXIN
INFLAMMATION, 14(3), 325–335.
TL;DR:
Intravitreal injection of human recombinant tumor necrosis factor-alpha induced inflammation in the rabbit eye characterized by dilation of blood vessels in the iris, disruption of the blood-ocular barriers, infiltration of inflammatory cells into the anterior chamber, and accumulation of prostaglandin E in intraocular fluids differed from that reported for intravitreally injected endotoxin in terms of time course and the types ofinflammatory cells in the aqueous humor.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1989 journal article
DIMETHYLTHIOUREA INHIBITS THE INFLAMMATORY RESPONSE TO INTRAVITREALLY-INJECTED ENDOTOXIN
EXPERIMENTAL EYE RESEARCH, 48(4), 561–567.
MeSH headings : Animals; Endotoxins; Escherichia coli; Male; Rabbits; Thiourea / administration & dosage; Thiourea / analogs & derivatives; Thiourea / pharmacology; Uveitis, Anterior / chemically induced; Uveitis, Anterior / prevention & control; Vitreous Body
TL;DR:
The ability of dimethylthiourea to significantly inhibit the inflammatory response to intravitreally-injected endotoxin suggests that toxic oxygen metabolites may play an important role in the initiation and/or propagation of this form of acute anterior uveitis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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