@article{almeida_shive_harvey_borst_cohen_2018, title={What is your diagnosis?}, volume={252}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-85040519711&partnerID=MN8TOARS}, DOI={10.2460/javma.252.2.173}, abstractNote={On clinical examination, the dog was bright, alert and responsive with a body weight of 17.2kg and a body condition score of 5/9. The mucous membranes were pink and moist, with a capillary refill time of one second. The heart rate was 140 beats/min but the dog was quite nervous. The dog was panting but no adventitious lung sounds were auscultated. A clear abdominal fluid thrill was detected but there were no other specific finding on palpation. The rectal temperature was normal at 38.9°C.}, number={2}, journal={Journal of the American Veterinary Medical Association}, author={Almeida, S.M. Bessauer and Shive, H.R. and Harvey, J.B. and Borst, Luke and Cohen, Eli}, year={2018}, pages={173–175} }
 @article{harvey_hong_bhusari_ton_wang_foley_peddada_hooth_devito_nyska_et al._2016, title={F344/NTac Rats Chronically Exposed to Bromodichloroacetic Acid Develop Mammary Adenocarcinomas With Mixed Luminal/Basal Phenotype and Tgf beta Dysregulation}, volume={53}, ISSN={["1544-2217"]}, DOI={10.1177/0300985815571680}, abstractNote={ Breast cancer is the most common cancer and the second-leading cause of cancer mortality in women in the United States. A recent 2-year National Toxicology Program carcinogenicity study showed an increased incidence of proliferative mammary lesions (hyperplasia, fibroadenoma, adenocarcinoma) in F344/NTac rats exposed to bromodichloroacetic acid (BDCA), a disinfection by-product in finished drinking water with widespread human exposure. We hypothesized that the increase in mammary tumors observed in BDCA-exposed F344/NTac rats may be due to underlying molecular changes relevant for human breast cancer. The objective of the study was to compare (1) gene and protein expression and (2) mutation spectra of relevant human breast cancer genes between normal untreated mammary gland and mammary tumors from control and BDCA-exposed animals to identify molecular changes relevant for human cancer. Histologically, adenocarcinomas from control and BDCA-exposed animals were morphologically very similar, were estrogen/progesterone receptor positive, and displayed a mixed luminal/basal phenotype. Gene expression analysis showed a positive trend in the number of genes associated with human breast cancer, with proportionally more genes represented in the BDCA-treated tumor group. Additionally, a 5-gene signature representing possible Tgfβ pathway activation in BDCA-treated adenocarcinomas was observed, suggesting that this pathway may be involved in the increased incidence of mammary tumors in BDCA-exposed animals. }, number={1}, journal={VETERINARY PATHOLOGY}, author={Harvey, J. B. and Hong, H. -H. L. and Bhusari, S. and Ton, T. -V. and Wang, Y. and Foley, J. F. and Peddada, S. D. and Hooth, M. and DeVito, M. and Nyska, A. and et al.}, year={2016}, month={Jan}, pages={170–181} }
 @article{harvey_osborne_hong_bhusari_ton_pandiri_masinde_dunnick_peddada_elmore_et al._2015, title={Uterine Carcinomas in Tetrabromobisphenol A-exposed Wistar Han Rats Harbor Increased Tp53 Mutations and Mimic High-grade Type I Endometrial Carcinomas in Women}, volume={43}, ISSN={["1533-1601"]}, DOI={10.1177/0192623315599256}, abstractNote={ Endometrial carcinoma is the most common gynecologic malignancy is the United States and accounts for 6% of all cancers in women. The disease is classified as type I or type II based on clinicopathologic and molecular features. It is a multifactorial disease with a number of risk factors, including environmental exposures. How environmental exposures, such as flame retardants, may affect the incidence of endometrial cancer is a topic of current and ongoing interest. Tetrabromobisphenol A (TBBPA) is a widely used brominated flame retardant found in a variety of household products. A recent 2-year National Toxicology Program carcinogenicity study found that exposure to TBBPA was associated with a marked increase in the development of uterine tumors, specifically uterine carcinomas, in Wistar Han rats. Molecularly, TBBPA-induced uterine carcinomas in Wistar Han rats were characterized by a marked increase in tumor protein 53 mutation compared to spontaneous uterine carcinomas, as well as overexpression of human epidermal growth factor receptor 2. Similar to spontaneous carcinomas, tumors in TBBPA-exposed rats were estrogen receptor-alpha positive and progesterone receptor negative by immunohistochemistry. The morphologic and molecular features of uterine carcinomas in TBBPA-exposed rats resemble those of high-grade type I tumors in women, and these data suggest that exposure to TBBPA may pose an increased cancer risk. }, number={8}, journal={TOXICOLOGIC PATHOLOGY}, author={Harvey, Janice B. and Osborne, Tanasa S. and Hong, Hue-Hua L. and Bhusari, Sachin and Ton, Tai-Vu and Pandiri, Arun R. and Masinde, Tiwanda and Dunnick, June and Peddada, Shyamal and Elmore, Susan and et al.}, year={2015}, month={Dec}, pages={1103–1113} }