Works (20)

Updated: March 29th, 2024 08:47

2021 journal article

Perinatal activation of ER alpha and ER beta but not GPER-1 masculinizes female rat caudate-putamen medium spiny neuron electrophysiological properties

JOURNAL OF NEUROPHYSIOLOGY, 125(6), 2322–2338.

By: J. Cao n & J. Meitzen n

author keywords: < em > caudate putamen <; em >; < em > dorsal striatum <; em >; < em > electrophysiology <; em >; < em > estradiol <; em >; < em > estrogen receptor <; em >
MeSH headings : Animals; Animals, Newborn; Caudate Nucleus / drug effects; Electrophysiological Phenomena / drug effects; Estradiol / administration & dosage; Estradiol / pharmacology; Estrogen Receptor alpha / agonists; Estrogen Receptor alpha / drug effects; Estrogen Receptor beta / agonists; Estrogen Receptor beta / drug effects; Estrogens / administration & dosage; Estrogens / pharmacology; Female; GABAergic Neurons / drug effects; Male; Patch-Clamp Techniques; Putamen / drug effects; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled / drug effects; Sex Characteristics
TL;DR: It is indicated that perinatal estradiol exposure masculinizes MSN electrophysiological phenotype via activation of ERα and ERβ. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 6, 2021

2020 journal article

The estrous cycle modulates rat caudate-putamen medium spiny neuron physiology

EUROPEAN JOURNAL OF NEUROSCIENCE, 52(1), 2737–2755.

By: J. Willett n, J. Cao n, A. Johnson n, O. Patel n, D. Dorris n & J. Meitzen n

author keywords: caudate-putamen; electrophysiology; estrous cycle; excitability; medium spiny neuron; sex differences
MeSH headings : Action Potentials; Animals; Estrous Cycle; Female; Male; Neurons; Nucleus Accumbens; Putamen; Rats
TL;DR: Recordings indicate that female caudate–putamen MSNs are sensitive to the estrous cycle, and the importance of considering neuroendocrine state in studies of neuron physiology is considered. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 12, 2019

2019 journal article

Electrophysiological Properties of Medium Spiny Neuron Subtypes in the Caudate-Putamen of Prepubertal Male and Female Drd1a-tdTomato Line 6 BAC Transgenic Mice

ENEURO, 6(2).

By: J. Willett n, J. Cao*, D. Dorris*, A. Johnson*, L. Ginnari* & J. Meitzen n

author keywords: caudate putamen; electrophysiology; intrinsic excitability; medium spiny neurons; rodent; sex differences
MeSH headings : Animals; Corpus Striatum / cytology; Corpus Striatum / physiology; Electrophysiology; Female; Male; Mice; Mice, Transgenic; Neurons / cytology; Neurons / physiology; Organ Culture Techniques; Sex Characteristics; Synaptic Potentials / physiology
TL;DR: A comprehensive evaluation of mouse caudate-putamen MSN subtype electrophysiological properties across females and males is provided, both confirming and extending previous studies. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: May 28, 2019

2018 journal article

Electrophysiological properties of medium spiny neurons in the nucleus accumbens core of prepubertal male and female Drd1a-tdTomato line 6 BAC transgenic mice

JOURNAL OF NEUROPHYSIOLOGY, 120(4), 1712–1727.

By: J. Cao n, D. Dorris n & J. Meitzen n

author keywords: medium spiny neuron; mice; nucleus accumbens; sex; ventral striatum
MeSH headings : Action Potentials; Animals; Excitatory Postsynaptic Potentials; Female; Male; Mice; Mice, Inbred C57BL; Miniature Postsynaptic Potentials; Neurons / physiology; Nucleus Accumbens / growth & development; Nucleus Accumbens / physiology; Sex Factors
TL;DR: This research provides the most comprehensive assessment of medium spiny neuron subtype electrophysiological properties to date in a critical brain region, the nucleus accumbens core, and represents the first evaluation of whether mouse medium sp Tiny neuron sub type electrophYSiological properties differ by sex. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: December 10, 2018

2018 review

Sex Differences in Medium Spiny neuron excitability and Glutamatergic Synaptic input: Heterogeneity Across Striatal Regions and evidence for Estradiol-Dependent Sexual Differentiation

[Review of ]. FRONTIERS IN ENDOCRINOLOGY, 9.

By: J. Cao n, J. Willett n, D. Dorris n & J. Meitzen n

author keywords: sex; estradiol; hormones; striatum; medium spiny neuron; nucleus accumbens; caudate-putamen; electrophysiology
TL;DR: Sex differences in rat MSN glutamatergic synaptic input and intrinsic excitability across striatal regions are reviewed, including evidence for estradiol-mediated sexual differentiation in the nucleus AcbC. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Effects of perinatal bisphenol A exposure on the volume of sexually-dimorphic nuclei of juvenile rats: A CLARITY-SPA consortium study

NEUROTOXICOLOGY, 63, 33–42.

By: S. Arambula n, J. Fuchs n, J. Cao n & H. Patisaul n

author keywords: Bisphenol A; Brain; Hypothalamus; Amygdala; Locus coeruleus; Sexually dimorphic
MeSH headings : Analysis of Variance; Animals; Animals, Newborn; Benzhydryl Compounds / toxicity; Brain / drug effects; Brain / pathology; Dose-Response Relationship, Drug; Endocrine Disruptors / toxicity; Estrogens / pharmacology; Ethinyl Estradiol / pharmacology; Female; Male; Phenols / toxicity; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Rats; Rats, Sprague-Dawley; Sex Characteristics
TL;DR: The testing of the hypothesis that perinatal BPA exposure would induce morphological changes in hormone sensitive, sexually dimorphic brain regions suggest the developing brain is vulnerable to endocrine disruption by BPA at exposure levels below previous estimates by regulatory agencies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

Genetic sex and the volumes of the caudate-putamen, nucleus accumbens core and shell: original data and a review

BRAIN STRUCTURE & FUNCTION, 221(8), 4257–4267.

By: J. Wong n, J. Cao n, D. Dorris n & J. Meitzen n

author keywords: Striatum; Caudate-putamen; Dorsal striatum; Ventral striatum; Volume; Nucleus accumbens; Sex; Hemisphere; Lateralization
MeSH headings : Animals; Caudate Nucleus / anatomy & histology; Caudate Nucleus / physiology; Female; Male; Nucleus Accumbens / anatomy & histology; Nucleus Accumbens / physiology; Preoptic Area / anatomy & histology; Preoptic Area / physiology; Putamen / anatomy & histology; Putamen / physiology; Rats; Rats, Sprague-Dawley; Sex Characteristics
TL;DR: Findings complement previous reports of lateralized nucleus accumbens volume in humans, and suggest that this may possibly be driven via hemispheric differences in nucleus Accumbens core volume. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

Interaction of bisphenol A (BPA) and soy phytoestrogens on sexually dimorphic sociosexual behaviors in male and female rats

HORMONES AND BEHAVIOR, 84, 121–126.

By: K. Hicks n, A. Sullivan n, J. Cao n, E. Sluzas n, M. Rebuli n & H. Patisaul n

author keywords: Endocrine disruption; Neuroendocrine disruption; Neuropeptides; Social; Diet; Open field; Affiliation; Activity; Environment
MeSH headings : Animals; Benzhydryl Compounds / pharmacology; Endocrine Disruptors / pharmacology; Exploratory Behavior / drug effects; Female; Isoflavones / pharmacology; Male; Phenols / pharmacology; Phytoestrogens / pharmacology; Rats; Sexual Behavior, Animal / drug effects; Social Behavior
TL;DR: Testing the individual and combined effects of low dose oral BPA and soy diet or the individual isoflavone genistein on rat sociosexual behaviors with the hypothesis that soy would obfuscate any BPA-related effects reinforces that environmental factors can shape complex behaviors and even reverse expected sex differences. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

Neonatal Masculinization Blocks Increased Excitatory Synaptic Input in Female Rat Nucleus Accumbens Core

ENDOCRINOLOGY, 157(8), 3181–3196.

By: J. Cao n, D. Dorris n & J. Meitzen n

MeSH headings : Animals; Animals, Newborn; Estradiol / pharmacology; Excitatory Postsynaptic Potentials / drug effects; Excitatory Postsynaptic Potentials / physiology; Female; Feminization / chemically induced; Feminization / pathology; Feminization / physiopathology; Male; Nucleus Accumbens / cytology; Nucleus Accumbens / drug effects; Nucleus Accumbens / physiology; Rats; Rats, Sprague-Dawley; Sex Characteristics; Sexual Maturation / drug effects; Sexual Maturation / physiology; Synaptic Transmission / drug effects; Synaptic Transmission / physiology
TL;DR: It is concluded that excitatory synaptic input onto AcbC MSNs is organized long before adulthood via steroid sex hormone action, providing new insight into a mechanism by which sex differences in motivated behavior and other AbcC functions may be generated or compromised. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

No Evidence for Sex Differences in the Electrophysiological Properties and Excitatory Synaptic Input onto Nucleus Accumbens Shell Medium Spiny Neurons

ENEURO, 3(1).

By: J. Willett n, T. Will n, C. Hauser n, D. Dorris n, J. Cao n & J. Meitzen n

author keywords: genetic sex; intrinsic electrophysiological properties; male and female rats; medium spiny neuron; mEPSC; striatum
MeSH headings : Action Potentials; Animals; Excitatory Postsynaptic Potentials; Female; Interneurons / physiology; Male; Membrane Potentials; Miniature Postsynaptic Potentials; Nucleus Accumbens / physiology; Rats; Rats, Sprague-Dawley; Sex Characteristics
TL;DR: Overall, it appears that sex differences in striatal function, including motivated behavior and reward, are likely mediated by other factors and striatal regions. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Intrinsic excitability varies by sex in prepubertal striatal medium spiny neurons

JOURNAL OF NEUROPHYSIOLOGY, 113(3), 720–729.

By: D. Dorris n, J. Cao n, J. Willett n, C. Hauser n & J. Meitzen n

author keywords: intrinsic excitability; sex differences; medium spiny neuron; dorsal striatum; mEPSC
MeSH headings : Action Potentials; Animals; Corpus Striatum / cytology; Corpus Striatum / growth & development; Corpus Striatum / physiology; Female; Male; Neurons / physiology; Rats; Rats, Sprague-Dawley; Sex Factors
TL;DR: It is indicated that MSN excitability is increased in prepubertal females compared with males, providing a new mechanism that potentially contributes to generating sex differences in striatal-mediated processes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Soy but not bisphenol A (BPA) or the phytoestrogen genistin alters developmental weight gain and food intake in pregnant rats and their offspring

REPRODUCTIVE TOXICOLOGY, 58, 282–294.

By: J. Cao n, R. Echelberger n, M. Liu*, E. Sluzas n, K. McCaffrey n, B. Buckley*, H. Patisaul n

author keywords: Endocrine disruption; Genistein; Phytoestrogens; Behavior; Sexually dimorphic; Obesogen; Body weight; Metabolic
MeSH headings : Age Factors; Animal Nutritional Physiological Phenomena / drug effects; Animals; Benzhydryl Compounds / metabolism; Benzhydryl Compounds / toxicity; Dietary Proteins / metabolism; Dietary Proteins / toxicity; Eating / drug effects; Endocrine Disruptors / metabolism; Endocrine Disruptors / toxicity; Female; Genistein / metabolism; Genistein / toxicity; Male; Maternal Nutritional Physiological Phenomena / drug effects; Nutritional Status / drug effects; Obesity / chemically induced; Obesity / physiopathology; Phenols / metabolism; Phenols / toxicity; Phytoestrogens / metabolism; Phytoestrogens / toxicity; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Wistar; Risk Assessment; Sexual Maturation / drug effects; Soybean Proteins / metabolism; Soybean Proteins / toxicity; Weight Gain / drug effects
TL;DR: Individual and combinatorial effects of soy diet or the isoflavone genistein with bisphenol A with BPA on body weight, ingestive behavior and female puberal onset in Wistar rats are assessed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Investigation of the Effects of Subchronic Low Dose Oral Exposure to Bisphenol A (BPA) and Ethinyl Estradiol (EE) on Estrogen Receptor Expression in the Juvenile and Adult Female Rat Hypothalamus

TOXICOLOGICAL SCIENCES, 140(1), 190–203.

By: M. Rebuli n, J. Cao n, E. Sluzas n, K. Delclos*, L. Camacho*, S. Lewis*, M. Vanlandingham*, H. Patisaul n

author keywords: brain; endocrine disruptor; endocrine disruption; hypothalamus; development; subchronic exposure; sexually dimorphic; ethinyl estradiol; bisphenol A
MeSH headings : Aging / metabolism; Animals; Benzhydryl Compounds / toxicity; Dose-Response Relationship, Drug; Estrogen Receptor alpha / genetics; Estrogen Receptor beta / genetics; Ethinyl Estradiol / toxicity; Female; Gene Expression / drug effects; Hypothalamus / drug effects; Hypothalamus / embryology; Hypothalamus / growth & development; Hypothalamus / metabolism; Male; Phenols / toxicity; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / metabolism; Rats, Sprague-Dawley; Receptors, Estrogen / genetics; Sex Characteristics
TL;DR: The impact of subchronic exposure from gestation to adulthood to oral doses of BPA below the current no-observed-adverse-effect level (NOAEL) of 5 mg/kg body weight (bw)/day on estrogen receptor (ESR) expression in sexually dimorphic brain regions of prepubertal and adult female rats is examined. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 article

Sex-specific Esr2 mRNA expression in the rat hypothalamus and amygdala is altered by neonatal bisphenol A exposure

Cao, J., Joyner, L., Mickens, J. A., Leyrer, S. M., & Patisaul, H. B. (2014, April). REPRODUCTION, Vol. 147, pp. 537–554.

By: J. Cao*, L. Joyner, J. Mickens*, S. Leyrer & H. Patisaul*

MeSH headings : Amygdala / drug effects; Amygdala / growth & development; Amygdala / metabolism; Animals; Animals, Newborn; Behavior, Animal / drug effects; Benzhydryl Compounds / toxicity; Dose-Response Relationship, Drug; Estradiol / analogs & derivatives; Estradiol / pharmacology; Estrogen Receptor beta / genetics; Estrogen Receptor beta / metabolism; Female; Gene Expression Regulation, Developmental / drug effects; Hypothalamus / drug effects; Hypothalamus / growth & development; Hypothalamus / metabolism; Male; Phenols / toxicity; Rats; Rats, Long-Evans; Sex Factors; Sexual Behavior, Animal / drug effects; Social Behavior
TL;DR: Testing the hypothesis that neonatal bisphenol A exposure can alter sex-specific postnatal Esr2 (Erβ) expression in brain regions fundamental to sociosexual behavior in rat demonstrates that region- and sex- specific EsR2 expression is vulnerable to neonatal BPA exposure in regions of the developing brain critical to socIosexual behavior. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 journal article

Prenatal Bisphenol A Exposure Alters Sex-Specific Estrogen Receptor Expression in the Neonatal Rat Hypothalamus and Amygdala

TOXICOLOGICAL SCIENCES, 133(1), 157–173.

By: J. Cao n, M. Rebuli n, J. Rogers n, K. Todd n, S. Leyrer n, S. Ferguson*, H. Patisaul n

author keywords: brain; endocrine disruptor; endocrine disruption; hypothalamus; development; sexually dimorphic; ethinyl estradiol
MeSH headings : Amygdala / drug effects; Amygdala / growth & development; Amygdala / metabolism; Animals; Animals, Newborn; Benzhydryl Compounds / toxicity; Dose-Response Relationship, Drug; Endocrine Disruptors / toxicity; Estrogen Receptor alpha / genetics; Estrogen Receptor beta / genetics; Female; Gene Expression Regulation, Developmental / drug effects; Hypothalamus / drug effects; Hypothalamus / growth & development; Hypothalamus / metabolism; Male; Phenols / toxicity; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / genetics; Prenatal Exposure Delayed Effects / metabolism; Rats; Rats, Sprague-Dawley; Receptors, Estrogen / genetics; Sex Factors
TL;DR: Results indicate that ESR expression in the neonatal brain of both sexes can be altered by low-dose prenatal BPA exposure, and the potential for gavage to influence geneexpression in the developing brain is highlighted. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 journal article

Sex-specific expression of estrogen receptors α and β and Kiss1 in the postnatal rat amygdala

Journal of Comparative Neurology, 521(2), 465–478.

By: J. Cao n & H. Patisaul n

author keywords: development; kisspeptin; sexually dimorphic; hypothalamus; neonatal
MeSH headings : Amygdala / growth & development; Amygdala / metabolism; Animals; Animals, Newborn; Estrogen Receptor alpha / biosynthesis; Estrogen Receptor alpha / genetics; Estrogen Receptor beta / biosynthesis; Estrogen Receptor beta / genetics; Female; Hippocampus / metabolism; Image Processing, Computer-Assisted; In Situ Hybridization; Kisspeptins / biosynthesis; Kisspeptins / genetics; Male; Pregnancy; RNA, Messenger / biosynthesis; RNA, Messenger / genetics; Rats; Rats, Long-Evans; Sex Characteristics; Sexual Maturation
TL;DR: Data reveal that ER expression is region‐specific within the neonatal amygdala, which likely contribute to sex differences in sociosexual behavior across the lifespan. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2011 journal article

Aryl hydrocarbon receptor activation in lactotropes and gonadotropes interferes with estradiol-dependent and -independent preprolactin, glycoprotein alpha and luteinizing hormone beta gene expression

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 333(2), 151–159.

By: J. Cao n, H. Patisaul n & S. Petersen*

author keywords: Dioxin; Ahr; Antiestrogen; Prl; LH; Estradiol
MeSH headings : Animals; Aryl Hydrocarbon Hydroxylases / genetics; Aryl Hydrocarbon Hydroxylases / metabolism; Cytochrome P-450 CYP1A1 / genetics; Cytochrome P-450 CYP1A1 / metabolism; Cytochrome P-450 CYP1A2 / genetics; Cytochrome P-450 CYP1A2 / metabolism; Cytochrome P-450 CYP1B1; Estradiol / pharmacology; Estrogen Receptor alpha / genetics; Estrogen Receptor alpha / metabolism; Female; Gene Expression Regulation / drug effects; Glycoprotein Hormones, alpha Subunit / genetics; Glycoprotein Hormones, alpha Subunit / metabolism; Gonadotrophs / cytology; Gonadotrophs / drug effects; Gonadotrophs / metabolism; Immunohistochemistry; In Situ Hybridization; Lactotrophs / cytology; Lactotrophs / drug effects; Lactotrophs / metabolism; Luteinizing Hormone, beta Subunit / genetics; Luteinizing Hormone, beta Subunit / metabolism; Pituitary Gland / cytology; Pituitary Gland / drug effects; Pituitary Gland / enzymology; Polychlorinated Dibenzodioxins / pharmacology; Prolactin / genetics; Prolactin / metabolism; Protein Precursors / genetics; Protein Precursors / metabolism; RNA, Messenger / genetics; RNA, Messenger / metabolism; Rats; Rats, Sprague-Dawley; Receptors, Aryl Hydrocarbon / genetics; Receptors, Aryl Hydrocarbon / metabolism
TL;DR: It is found that TCDD upregulated known AhR target genes, cytochrome p450 1a1 (Cyp1a1), Cyp1a2 and Cyp1b1 in the rat pituitary gland, and complex interactions between Ahr and Esr alter Prl and luteinizing hormone (LH) synthesis by direct actions in lactotropes and gonadotropes. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

Neonatal exposure to genistein adversely impacts the ontogeny of hypothalamic kisspeptin signaling pathways and ovarian development in the peripubertal female rat

REPRODUCTIVE TOXICOLOGY, 31(3), 280–289.

By: S. Losa n, K. Todd n, A. Sullivan n, J. Cao n, J. Mickens n & H. Patisaul n

author keywords: Soy; Estrogen; Phytoestrogens; Endocrine disruptors; Development; Reproductive; Fertility; Ovary
MeSH headings : Animals; Animals, Newborn; Arcuate Nucleus of Hypothalamus / drug effects; Arcuate Nucleus of Hypothalamus / metabolism; Arcuate Nucleus of Hypothalamus / pathology; Female; Gene Expression Regulation, Developmental / drug effects; Genistein / toxicity; Hypothalamus / drug effects; Hypothalamus / metabolism; Immunohistochemistry; In Situ Hybridization; Kisspeptins; Midline Thalamic Nuclei / drug effects; Midline Thalamic Nuclei / metabolism; Midline Thalamic Nuclei / pathology; Ovary / drug effects; Ovary / growth & development; Phytoestrogens / toxicity; Proteins / genetics; Proteins / metabolism; RNA, Messenger / analysis; Rats; Rats, Long-Evans; Rats, Wistar; Sex Factors; Sexual Maturation / drug effects; Sexual Maturation / physiology; Signal Transduction / drug effects
TL;DR: Female rats exposed to the phytoestrogen genistein, estradiol benzoate, or vehicle from post natal day (P) 0-3 via subcutaneous injection were exposed to estrogenic endocrine disrupting compounds to establish sex specific development of KISS gene expression, cell number and neural fiber density across peripuberty. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

Sexually dimorphic expression of hypothalamic estrogen receptors α and β and kiss1 in neonatal male and female rats

The Journal of Comparative Neurology, 519(15), 2954–2977.

By: J. Cao n & H. Patisaul n

author keywords: development; anteroventral periventricular nucleus (AVPV); medial preoptic area (MPOA); arcuate nucleus (ARC); kisspeptin; sex differences
MeSH headings : Animals; Autoradiography; Estrogen Receptor alpha / genetics; Estrogen Receptor alpha / metabolism; Estrogen Receptor beta / genetics; Estrogen Receptor beta / metabolism; Female; Hypothalamus / anatomy & histology; Hypothalamus / metabolism; Kisspeptins / genetics; Kisspeptins / metabolism; Male; Neurons / cytology; Neurons / metabolism; Pregnancy; Rats; Sex Characteristics; Signal Transduction / physiology
TL;DR: Detailed profiles of neonatal Kiss1 and ERs mRNA levels will help elucidate the relative roles each plays in the sex‐specific, estrogen‐dependent organization of gonadotropin signaling pathways and provide evidence that Kiss1 may play a role in the sexual dimorphic organization of the neonatal brain. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2009 journal article

Cell Growth Inhibition and Gene Expression Regulation by (-)-Epigallocatechin-3-Gallate in Human Cervical Cancer Cells

ARCHIVES OF PHARMACAL RESEARCH, 32(9), 1309–1315.

By: Y. Qiao*, J. Cao n, L. Xie* & X. Shi*

author keywords: EGCG; Cervical cancer; HPV; ER; Aromatase
MeSH headings : Antineoplastic Agents / pharmacology; Apoptosis / drug effects; Aromatase / genetics; Catechin / analogs & derivatives; Catechin / pharmacology; Cell Cycle / drug effects; Cell Proliferation / drug effects; Estrogen Receptor alpha / genetics; Estrogen Receptor beta / genetics; Female; Gene Expression Regulation, Neoplastic / drug effects; HeLa Cells; Human papillomavirus 16 / isolation & purification; Humans; Uterine Cervical Neoplasms / drug therapy; Uterine Cervical Neoplasms / genetics; Uterine Cervical Neoplasms / pathology; Uterine Cervical Neoplasms / virology
TL;DR: EGCG has shown its antitumor ability and perhaps a potential regimen for cancer patients and may be suitable for prevention and treatment of cervical cancer. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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