Works (69)

Updated: August 2nd, 2023 21:16

2020 journal article

The Solution Structures and Interaction of SinR and SinI: Elucidating the Mechanism of Action of the Master Regulator Switch for Biofilm Formation in Bacillus subtilis

JOURNAL OF MOLECULAR BIOLOGY, 432(2), 343โ€“357.

By: M. Miltonโ€‰*, G. Draughn n, B. Bobay n, S. Stowe n, A. Olson n, E. Feldmann n, R. Thompson*, K. Myers n ...

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: Biofilms; Bacillus subtilis; Transcriptional regulation; NMR solution structure
MeSH headings : Amino Acid Sequence / genetics; Bacillus subtilis / genetics; Bacillus subtilis / ultrastructure; Bacterial Proteins / chemistry; Bacterial Proteins / genetics; Bacterial Proteins / ultrastructure; Biofilms / growth & development; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / genetics; DNA-Binding Proteins / ultrastructure; Gene Expression Regulation, Bacterial / genetics; Molecular Docking Simulation; Mutation / genetics; Protein Binding / genetics; Protein Conformation
Source: Web Of Science
Added: February 27, 2020

2018 journal article

Re-sensitizing Multidrug Resistant Bacteria to Antibiotics by Targeting Bacterial Response Regulators: Characterization and Comparison of Interactions between 2-Aminoimidazoles and the Response Regulators BfmR from Acinetobacter baumannii and QseB from Francisella spp.

FRONTIERS IN MOLECULAR BIOSCIENCES, 5.

By: M. Miltonโ€‰*, B. Minrovic n, D. Harrisโ€‰*, B. Kang*, D. Jungโ€‰*, C. Lewis n, R. Thompson*, R. Melander n ...

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: biofilms; antibiotic resistance; two-component systems; response regulators; Acinetobacter baumannii; Francisella
Source: Web Of Science
Added: January 28, 2019

2018 journal article

The Structure of the Biofilm-controlling Response Regulator BfmR from Acinetobacter baumannii Reveals Details of Its DNA-binding Mechanism

Journal of Molecular Biology, 430(6), 806โ€“821.

By: G. Draughn n, M. Miltonโ€‰ n, E. Feldmann n, B. Bobayโ€‰ n, B. Roth*, A. Olson n, R. Thompson n, L. Actisโ€‰*, C. Davies*, J. Cavanagh*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Acinetobacter baumannii / drug effects; Acinetobacter baumannii / genetics; Acinetobacter baumannii / metabolism; Anti-Bacterial Agents / pharmacology; Bacterial Proteins / chemistry; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Base Sequence; Biofilms / drug effects; Biofilms / growth & development; Cloning, Molecular; Crystallography, X-Ray; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Gene Expression Regulation, Bacterial; Models, Molecular; Phosphorylation; Promoter Regions, Genetic; Protein Conformation
Sources: Crossref, Web Of Science
Added: August 6, 2018

2017 journal article

Evaluation of a 2-aminoimidazole variant as adjuvant treatment for dermal bacterial infections

Drug Design Development and Therapy, 11, 153โ€“162.

By: G. Draughn, C. Allen, P. Routh, M. Stone, K. Kirker, A. Boegli, R. Schuchman, K. Linder ...

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Potentiation of Francisella resistance to conventional antibiotics through small molecule adjuvants

MEDCHEMCOMM, 7(1), 128โ€“131.

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Augmenting anti-cancer natural products with a small molecule adjuvant

Marine Drugs, 13(1), 65โ€“75.

By: P. Wahome, K. Beauchesne, A. Pedone, J. Cavanagh, C. Melander, P. Zimba, P. Moeller

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Membrane-Permeabilizing Activity of Reverse-Amide 2-Aminoimidazole Antibiofilm Agents Against Acinetobacter baumannii

CURRENT DRUG DELIVERY, 12(2), 223โ€“230.

By: S. Stowe*, R. Thompson*, L. Peng*, Z. Su*, M. Blackledge*, G. Draughn, W. Coe, E. Johannes* ...

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: 2-aminoimidazole; Acinetobacter baumannii; biofilm; membrane permeabilization; reverse amide; SEM
MeSH headings : Acinetobacter baumannii / drug effects; Amides / chemistry; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Biofilms / drug effects; Cell Membrane Permeability / drug effects; Cells, Cultured; Cross Infection; Imidazoles / chemistry; Imidazoles / pharmacology; Microbial Sensitivity Tests
Source: Web Of Science
Added: August 6, 2018

2015 article

Teaching old drugs new tricks: Addressing resistance in Francisella

Feldmann, E. A., & Cavanagh, J. (2015, July 4). VIRULENCE, Vol. 6, pp. 414โ€“416.

By: E. Feldmann n & J. Cavanagh n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Animals; Biofilms / drug effects; Female; Francisella / drug effects; Maprotiline / chemistry; Maprotiline / pharmacology; Protein Kinases / metabolism; Tularemia / drug therapy
Source: Web Of Science
Added: August 6, 2018

2014 journal article

A DNA Mimic: The Structure and Mechanism of Action for the Anti-Repressor Protein AbbA

JOURNAL OF MOLECULAR BIOLOGY, 426(9), 1911โ€“1924.

By: A. Tucker n, B. Bobay n, A. Banse*, A. Olson n, E. Soderblom*, M. Moseleyโ€‰*, R. Thompson n, K. Varneyโ€‰*, R. Losick*, J. Cavanagh n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: transition state regulator; AbbA; DNA mimic; molecular docking; NMR
MeSH headings : Bacillus subtilis / chemistry; Bacillus subtilis / metabolism; Bacterial Proteins / chemistry; Bacterial Proteins / metabolism; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Docking Simulation; Protein Conformation; Protein Multimerization
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Chemical shift assignments and secondary structure prediction of the C-terminal domain of the response regulator BfmR from Acinetobacter baumannii

BIOMOLECULAR NMR ASSIGNMENTS, 8(1), 67โ€“70.

By: A. Olson n, R. Thompson n, C. Melanderโ€‰ n & J. Cavanagh n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: NMR; BfmR; Acinetobacter baumannii; Assignment
MeSH headings : Acinetobacter baumannii / metabolism; Bacterial Proteins / chemistry; Nuclear Magnetic Resonance, Biomolecular; Protein Structure, Secondary; Protein Structure, Tertiary
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Chemical shift assignments and secondary structure prediction of the master biofilm regulator, SinR, from Bacillus subtilis

BIOMOLECULAR NMR ASSIGNMENTS, 8(1), 155โ€“158.

By: S. Stowe n, A. Olson n, R. Losick* & J. Cavanagh n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: NMR; SinR; Bacillus subtilis; Biofilm regulation
MeSH headings : Bacillus subtilis / metabolism; Bacterial Proteins / chemistry; Biofilms; Nuclear Magnetic Resonance, Biomolecular; Protein Structure, Secondary
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Chemical shift assignments and secondary structure prediction of the phosphorelay protein VanU from Vibrio anguillarum

BIOMOLECULAR NMR ASSIGNMENTS, 8(1), 177โ€“179.

By: B. Bobay n, R. Thompson n, D. Milton* & J. Cavanagh n

co-author countries: Sweden ๐Ÿ‡ธ๐Ÿ‡ช United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: VanU; NMR; Vibrio anguillarum; Phosphorelay
MeSH headings : Bacterial Proteins / chemistry; Nuclear Magnetic Resonance, Biomolecular; Phosphotransferases / chemistry; Protein Structure, Secondary; Vibrio / metabolism
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Small-Molecule Suppression of beta-Lactam Resistance in Multidrug-Resistant Gram-Negative Pathogens

JOURNAL OF MEDICINAL CHEMISTRY, 57(17), 7450โ€“7458.

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Animals; Cell Line; Cell Survival / drug effects; Drug Resistance, Multiple, Bacterial / drug effects; Gram-Negative Bacteria / classification; Gram-Negative Bacteria / drug effects; Hemolysis / drug effects; Humans; Keratinocytes / cytology; Keratinocytes / drug effects; Microbial Sensitivity Tests; Sheep; Small Molecule Libraries / chemistry; Small Molecule Libraries / pharmacology; beta-Lactam Resistance / drug effects
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Structure and DNA-Binding Traits of the Transition State Regulator AbrB

STRUCTURE, 22(11), 1650โ€“1656.

By: A. Olson n, A. Tucker n, B. Bobay n, E. Soderblom*, M. Moseleyโ€‰*, R. Thompson n, J. Cavanagh n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Bacillus subtilis / metabolism; Bacterial Proteins / chemistry; Bacterial Proteins / metabolism; Binding Sites; DNA, Bacterial / metabolism; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / metabolism; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Docking Simulation; Protein Multimerization; Protein Structure, Secondary; Transcription Factors / chemistry; Transcription Factors / metabolism
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Chemical crosslinking and LC/MS analysis to determine protein domain orientation: Application to AbrB

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 431(2), 253โ€“257.

By: A. Olson*, F. Liu*, A. Tucker*, M. Goshe* & J. Cavanagh*

author keywords: NMR; Solution structure; Chemical crosslinking; Domain orientation; AbrB; Gas-phase cleavable
MeSH headings : Amino Acid Sequence; Bacterial Proteins / chemistry; Chromatography, Liquid; Cross-Linking Reagents / chemistry; DNA-Binding Proteins / chemistry; Molecular Sequence Data; Protein Structure, Tertiary; Tandem Mass Spectrometry; Transcription Factors / chemistry
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Evaluation of the toxicity of 2-aminoimidazole antibiofilm agents using both cellular and model organism systems

DRUG AND CHEMICAL TOXICOLOGY, 35(3), 310โ€“315.

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: 2-aminoimidazole; adjuvant; biofilm; Caenorhabditis elegans; toxicity; Toxicity of 2-aminoimidazole; antibiofilm agents
MeSH headings : Adjuvants, Pharmaceutic / toxicity; Animals; Anti-Bacterial Agents / pharmacology; Anti-Bacterial Agents / toxicity; Biofilms / drug effects; Caenorhabditis elegans; Cell Line; Dose-Response Relationship, Drug; Environmental Exposure; Fertility / drug effects; Humans; Imidazoles / pharmacology; Imidazoles / toxicity; Keratinocytes / metabolism; Tetrazolium Salts; Thiazoles; Toxicity Tests
Source: Web Of Science
Added: August 6, 2018

2012 journal article

H-1, C-13, and N-15 resonance assignments and secondary structure prediction of the full-length transition state regulator AbrB from Bacillus anthracis

BIOMOLECULAR NMR ASSIGNMENTS, 6(1), 95โ€“98.

By: A. Olson n, B. Bobay n, C. Melander n & J. Cavanagh n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: AbrB; NMR; Bacillus anthracis; Transition state regulator
MeSH headings : Bacillus anthracis; Bacterial Proteins / chemistry; DNA-Binding Proteins / chemistry; Nuclear Magnetic Resonance, Biomolecular; Protein Structure, Secondary; Transcription Factors / chemistry
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Identification of BfmR, a Response Regulator Involved in Biofilm Development, as a Target for a 2-Aminoimidazole-Based Antibiofilm Agent

BIOCHEMISTRY, 51(49), 9776โ€“9778.

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Acinetobacter baumannii / drug effects; Acinetobacter baumannii / growth & development; Bacterial Proteins / chemistry; Bacterial Proteins / physiology; Biofilms / drug effects; Imidazoles / pharmacology; Microscopy, Confocal; Models, Molecular
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Structural insights into the calcium-dependent interaction between calbindin-D28K and caspase-3

FEBS LETTERS, 586(20), 3582โ€“3589.

By: B. Bobay n, A. Stewart n, A. Tucker n, R. Thompson n, K. Varneyโ€‰* & J. Cavanagh n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: Calbindin-D28K; Caspase-3; Isothermal titration calorimetry; Molecular docking
MeSH headings : Calbindins; Calcium / metabolism; Caspase 3 / chemistry; Caspase 3 / metabolism; Enzyme Activation; Hydrogen Bonding; Molecular Docking Simulation; Protein Binding; Protein Conformation; S100 Calcium Binding Protein G / chemistry; S100 Calcium Binding Protein G / metabolism
Source: Web Of Science
Added: August 6, 2018

2011 review

Anti-biofilm compounds derived from marine sponges

[Review of ]. Marine Drugs, 9(10), 2010โ€“2035.

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Flustramine inspired synthesis and biological evaluation of pyrroloindoline triazole amides as novel inhibitors of bacterial biofilms

ORGANIC & BIOMOLECULAR CHEMISTRY, 9(15), 5476โ€“5481.

By: C. Bunders n, J. Cavanagh n & C. Melander n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Amides / chemical synthesis; Amides / chemistry; Amides / pharmacology; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Bacteria / drug effects; Biofilms / drug effects; Indole Alkaloids / chemistry; Indoles / chemical synthesis; Indoles / chemistry; Indoles / pharmacology; Inhibitory Concentration 50; Molecular Structure; Pyrroles / chemical synthesis; Pyrroles / chemistry; Pyrroles / pharmacology; Quantitative Structure-Activity Relationship; Small Molecule Libraries / chemical synthesis; Small Molecule Libraries / chemistry; Small Molecule Libraries / pharmacology
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Intercepting Bacterial Indole Signaling with Flustramine Derivatives

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 133(50), 20160โ€“20163.

By: C. Bunders n, M. Minvielle n, R. Worthington n, M. Ortiz n, J. Cavanagh n & C. Melander n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Escherichia coli / metabolism; Hydrocarbons, Brominated / metabolism; Indole Alkaloids / metabolism; Indoles / metabolism; Signal Transduction; Staphylococcus aureus / metabolism
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Observing selected domains in multi-domain proteins via sortase-mediated ligation and NMR spectroscopy

JOURNAL OF BIOMOLECULAR NMR, 49(1), 3โ€“7.

By: M. Refaei*, A. Combs*, D. Kojetinโ€‰*, J. Cavanagh n, C. Caperelli*, M. Rance*, J. Sapitro*, P. Tsang*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: Segmental labeling; Sortase A; Protein ligation; MecA; Enzyme-mediated ligation; NMR
MeSH headings : Amino Acid Sequence; Aminoacyltransferases / metabolism; Bacterial Proteins / chemistry; Bacterial Proteins / metabolism; Cysteine Endopeptidases / metabolism; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Nitrogen Isotopes / chemistry; Nuclear Magnetic Resonance, Biomolecular; Protein Structure, Tertiary; Proteins / chemistry; Proteins / metabolism; Recombinant Fusion Proteins / chemistry; Recombinant Fusion Proteins / metabolism; Staphylococcus aureus / enzymology
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Binding site on human immunoglobulin G for the affinity ligand HWRGWV

Journal of Molecular Recognition, 23(3), 271โ€“282.

By: H. Yang, P. Gurgel, D. Williams, B. Bobay, J. Cavanagh, D. Muddimanโ€‰, R. Carbonell

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Long range dynamic effects of point-mutations trap a response regulator in an active conformation

FEBS LETTERS, 584(19), 4203โ€“4207.

By: B. Bobay n, R. Thompson n, J. Hoch* & J. Cavanagh n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: NMR; Conformational transition; Intra-protein communication; Response regulator; Spo0F
MeSH headings : Bacillus subtilis / genetics; Bacillus subtilis / metabolism; Bacterial Proteins / chemistry; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Models, Molecular; Mutagenesis, Site-Directed; Mutant Proteins / chemistry; Mutant Proteins / genetics; Mutant Proteins / metabolism; Nuclear Magnetic Resonance, Biomolecular; Point Mutation; Principal Component Analysis; Protein Conformation; Second Messenger Systems / genetics; Signal Transduction / genetics; Thermodynamics
Source: Web Of Science
Added: August 6, 2018

2010 journal article

NMR Solution Structure and DNA-binding Model of the DNA-binding Domain of Competence Protein A

JOURNAL OF MOLECULAR BIOLOGY, 398(2), 248โ€“263.

By: C. Hobbs n, B. Bobay n, R. Thompson n, M. Peregoโ€‰* & J. Cavanagh n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: competence; ComA; NMR; two-component; response regulator
MeSH headings : Amino Acid Sequence; Bacillus subtilis / metabolism; Bacterial Proteins / chemistry; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; DNA / chemistry; DNA / metabolism; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Escherichia coli Proteins / chemistry; Escherichia coli Proteins / genetics; Escherichia coli Proteins / metabolism; Helix-Turn-Helix Motifs; Models, Molecular; Molecular Sequence Data; Nuclear Magnetic Resonance, Biomolecular; Protein Structure, Tertiary
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Synergistic Effects between Conventional Antibiotics and 2-Aminoimidazole-Derived Antibiofilm Agents

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 54(5), 2112โ€“2118.

By: S. Rogers n, R. Huigens n, J. Cavanagh n & C. Melander n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Acinetobacter baumannii / drug effects; Anti-Bacterial Agents / pharmacology; Bacteria / drug effects; Biofilms / drug effects; Calcium Chloride / pharmacology; Chlorides / pharmacology; Colistin / pharmacology; Drug Resistance, Bacterial; Drug Resistance, Multiple; Drug Synergism; Enterococcus faecium / drug effects; Erythrocytes / drug effects; Escherichia coli / drug effects; Humans; Imidazoles / chemistry; Imidazoles / pharmacology; Magnesium / pharmacology; Manganese Compounds / pharmacology; Methicillin-Resistant Staphylococcus aureus / drug effects; Novobiocin / pharmacology; Staphylococcus epidermidis / drug effects; Tobramycin / pharmacology; Triazoles / pharmacology
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Amide Isosteres of Oroidin: Assessment of Antibiofilm Activity and C. elegans Toxicity

JOURNAL OF MEDICINAL CHEMISTRY, 52(15), 4582โ€“4585.

By: J. Richards n, S. Reyes n, S. Stowe n, A. Tucker n, T. Ballard n, L. Mathies n, J. Cavanagh n, C. Melander n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Amides / chemical synthesis; Amides / pharmacology; Amides / toxicity; Animals; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / pharmacology; Biofilms / drug effects; Caenorhabditis elegans / drug effects; Pseudomonas aeruginosa / drug effects; Pseudomonas aeruginosa / physiology; Pyrroles / chemical synthesis; Pyrroles / pharmacology; Pyrroles / toxicity; Structure-Activity Relationship; Sulfonamides / chemical synthesis; Sulfonamides / pharmacology; Thiourea / chemical synthesis; Thiourea / pharmacology; Urea / chemical synthesis; Urea / pharmacology
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Binding site on human immunoglobulin G for the affinity ligand HWRGWV

Journal of Molecular Recognition, n/a-n/a.

By: H. Yangโ€‰ n, P. Gurgel n, D. Williams n, B. Bobayโ€‰ n, J. Cavanagh n, D. Muddiman nโ€‰, R. Carbonell n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: hexamer ligand; immunoglobulin G; glycosylation; mass spectrometry; computational docking; binding site
MeSH headings : Amino Acid Sequence; Animals; Binding Sites; Endopeptidases / metabolism; Humans; Immunoglobulin Fc Fragments / metabolism; Immunoglobulin G / chemistry; Immunoglobulin G / metabolism; Ligands; Models, Molecular; Molecular Sequence Data; Nerve Tissue Proteins / metabolism; Oligopeptides / chemistry; Oligopeptides / genetics; Oligopeptides / metabolism; Pepsin A / metabolism; Protein Binding; Protein Structure, Tertiary; Sequence Alignment; Staphylococcal Protein A / metabolism
Source: Crossref
Added: February 24, 2020

2009 journal article

Evaluation of dihydrooroidin as an antifouling additive in marine paint

INTERNATIONAL BIODETERIORATION & BIODEGRADATION, 63(4), 529โ€“532.

By: C. Melander n, P. Moeller*, T. Ballard n, J. Richards n, R. Huigens n & J. Cavanagh n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: Antifouling; Biofilms; Natural products
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Structural Characterization of the Conformational Change in Calbindin-D-28k upon Calcium Binding Using Differential Surface Modification Analyzed by Mass Spectrometry

BIOCHEMISTRY, 48(36), 8603โ€“8614.

By: C. Hobbs n, L. Deterdingโ€‰*, L. Pereraโ€‰*, B. Bobay n, R. Thompson n, T. Darden*, J. Cavanagh n, K. Tomer*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Amino Acid Sequence; Animals; Apoproteins / chemistry; Calbindin 1; Calbindins; Cysteine / chemistry; Disulfides / chemistry; EF Hand Motifs; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Rats; S100 Calcium Binding Protein G / chemistry; S100 Calcium Binding Protein G / metabolism; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Structural and Motional Contributions of the Bacillus subtilis ClpC N-Domain to Adaptor Protein Interactions

JOURNAL OF MOLECULAR BIOLOGY, 387(3), 639โ€“652.

By: D. Kojetinโ€‰*, P. McLaughlin n, R. Thompson n, D. Dubnau, P. Prepiak, M. Rance*, J. Cavanagh n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: competence; adaptor protein proteosome interactions; HSP100/Clp N-domain; NMR dynamics
MeSH headings : Adaptor Proteins, Vesicular Transport / chemistry; Adaptor Proteins, Vesicular Transport / genetics; Adaptor Proteins, Vesicular Transport / metabolism; Amino Acid Sequence; Bacillus subtilis / genetics; Bacillus subtilis / metabolism; Bacterial Proteins / chemistry; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Heat-Shock Proteins / chemistry; Heat-Shock Proteins / genetics; Heat-Shock Proteins / metabolism; Models, Molecular; Molecular Sequence Data; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Protein Structure, Secondary; Sequence Alignment; Static Electricity
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Co-Evolving Motions at Proteinโˆ’Protein Interfaces of Two-Component Signaling Systems Identified by Covariance Analysisโ€ 

Biochemistry, 47(30), 7782โ€“7784.

By: H. Szurmantโ€‰ n, B. Bobay n, R. Whiteโ€‰ n, D. Sullivanโ€‰ n, R. Thompson n, T. Hwaโ€‰ n, J. Hoch n, J. Cavanagh n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Analysis of Variance; Bacterial Proteins / chemistry; Bacterial Proteins / metabolism; Binding Sites; Magnetic Resonance Spectroscopy; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Proteins / chemistry; Proteins / metabolism; Signal Transduction
Sources: Crossref, Web Of Science
Added: August 6, 2018

2008 journal article

Control of bacterial biofilms with marine alkaloid derivatives

MOLECULAR BIOSYSTEMS, 4(6), 614โ€“621.

By: R. Huigens n, L. Maโ€‰*, C. Gambino n, P. Moeller*, A. Basso n, J. Cavanagh n, D. Wozniakโ€‰*, C. Melander n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Acinetobacter baumannii / drug effects; Acylation; Alkaloids / chemical synthesis; Alkaloids / chemistry; Alkaloids / pharmacology; Animals; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Biofilms / drug effects; Biofilms / growth & development; Bordetella bronchiseptica / drug effects; Cell Line; Dose-Response Relationship, Drug; Imidazoles / chemical synthesis; Imidazoles / chemistry; Imidazoles / pharmacology; Mice; Microbial Sensitivity Tests; Molecular Structure; Pseudomonas aeruginosa / drug effects; Rats; Staphylococcus aureus / drug effects
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Inhibition and dispersion of proteobacterial biofilms

Chemical Communications, (14), 1698.

By: J. Richards n, R. Huigens III, T. Ballard n, A. Basso n, J. Cavanagh n & C. Melander n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Biofilms / drug effects; Biofilms / growth & development; Dose-Response Relationship, Drug; Imidazoles / chemistry; Imidazoles / pharmacology; Inhibitory Concentration 50; Molecular Structure; Proteobacteria / drug effects; Proteobacteria / growth & development; Proteobacteria / physiology; Pyrroles / chemistry; Pyrroles / pharmacology
Sources: Crossref, NC State University Libraries
Added: August 6, 2018

2008 journal article

Insights into the Nature of DNA Binding of AbrB-like Transcription Factors

STRUCTURE, 16(11), 1702โ€“1713.

By: D. Sullivan n, B. Bobay n, D. Kojetinโ€‰*, R. Thompson n, M. Rance*, M. Strauch*, J. Cavanagh n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Bacillus subtilis / metabolism; Bacterial Proteins / chemistry; Bacterial Proteins / metabolism; Binding Sites; DNA / chemistry; DNA / metabolism; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / metabolism; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Models, Molecular; Protein Conformation; Thermodynamics; Transcription Factors / chemistry; Transcription Factors / metabolism
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Targeting RNA with cysteine-constrained peptides

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 18(2), 565โ€“567.

By: V. Burns n, B. Bobay n, A. Basso n, J. Cavanagh n & C. Melander n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: RNA; cyclic peptides; HADDOCK
MeSH headings : Base Sequence; Cysteine / chemistry; Humans; Models, Molecular; Peptides, Cyclic / chemistry; RNA / chemistry
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Abh and AbrB control of Bacillus subtilis antimicrobial gene expression

JOURNAL OF BACTERIOLOGY, 189(21), 7720โ€“7732.

By: M. Strauch*, B. Bobay n, J. Cavanagh n, F. Yao*, A. Wilson* & Y. Le Bretonโ€‰*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Bacillus subtilis / genetics; Bacillus subtilis / growth & development; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Base Sequence; Binding Sites; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Gene Expression Regulation, Bacterial; Genes, Bacterial; Kinetics; Molecular Sequence Data; Mutation; Plasmids; Transcription Factors / genetics; Transcription Factors / metabolism
Source: Web Of Science
Added: August 6, 2018

2007 journal article

NMR assignment of the N-terminal repeat domain of Bacillus subtilis ClpC

BIOMOLECULAR NMR ASSIGNMENTS, 1(2), 163โ€“165.

By: D. Kojetin*, P. McLaughlin n, R. Thompson n, R. Ventersโ€‰*, M. Rance* & J. Cavanagh n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: ClpC; Bacillus subtilis; N-domain; genetic competence; HSP100/AAA+
MeSH headings : Amino Acid Sequence; Bacterial Proteins / chemistry; Connexins / chemistry; Heat-Shock Proteins / chemistry; Magnetic Resonance Spectroscopy / methods; Protein Structure, Tertiary; Repetitive Sequences, Amino Acid
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Peptide binding proclivities of calcium loaded calbindin-D28k

FEBS LETTERS, 581(24), 4778โ€“4782.

By: D. Kordys n, B. Bobay n, R. Thompson n, R. Ventersโ€‰* & J. Cavanagh n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: calbindin-D28k; NMR; chemical shift; peptides; modeling
MeSH headings : Animals; Calbindin 1; Calbindins; Calcium / metabolism; Circular Dichroism; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Peptides / metabolism; Protein Binding; Protein Structure, Tertiary; Rats; S100 Calcium Binding Protein G / metabolism; Titrimetry
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Predominantly buried residues in the response regulator Spo0F influence specific sensor kinase recognition

FEBS LETTERS, 581(7), 1425โ€“1429.

By: P. McLaughlin n, B. Bobaya, E. Regel n, R. Thompson n, J. Hoch* & J. Cavanagh n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: sporulation; kinases; Spo0F mutants
MeSH headings : Alanine / chemistry; Alanine / genetics; Amino Acid Sequence; Amino Acid Substitution; Bacillus subtilis / metabolism; Bacillus subtilis / physiology; Bacterial Proteins / chemistry; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Histidine Kinase; Nuclear Magnetic Resonance, Biomolecular; Protein Conformation; Protein Interaction Mapping; Protein Kinases / chemistry; Protein Kinases / metabolism; Protein Structure, Secondary; Spores, Bacterial
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Tandem mass spectrometry acquisition approaches to enhance identification of protein-protein interactions using low-energy collision-induced dissociative chemical crosslinking reagents

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 21(21), 3395โ€“3408.

By: E. Soderblom n, B. Bobay n, J. Cavanagh n & M. Goshe n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Amino Acid Sequence; Bacillus subtilis / chemistry; Bacillus subtilis / metabolism; Bacterial Proteins / chemistry; Cross-Linking Reagents / chemistry; DNA-Binding Proteins / chemistry; Molecular Sequence Data; Peptide Mapping; Peptides / chemistry; Protein Conformation; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry / methods; Transcription Factors / chemistry
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Measurement of multisite oxidation kinetics reveals an active site conformational change in Spo0F as a result of protein oxidation

BIOCHEMISTRY, 45(20), 6260โ€“6266.

By: J. Sharpโ€‰ n, D. Sullivan n, J. Cavanagh n & K. Tomer n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Bacterial Proteins / chemistry; Bacterial Proteins / metabolism; Binding Sites; Circular Dichroism; Kinetics; Mass Spectrometry; Methionine / metabolism; Models, Molecular; Oxidation-Reduction; Phosphorylation; Protein Conformation; Structure-Activity Relationship
Source: Web Of Science
Added: August 6, 2018

2006 journal article

NMR structure of AbhN and comparison with AbrBN - First insights into the DNA binding promiscuity and specificity of AbrB-like transition state regulator proteins

JOURNAL OF BIOLOGICAL CHEMISTRY, 281(30), 21399โ€“21409.

By: B. Bobay n, G. Muellerโ€‰*, R. Thompson n, A. Murzin*, R. Ventersโ€‰*, M. Strauch*, J. Cavanagh n

co-author countries: United Kingdom of Great Britain and Northern Ireland ๐Ÿ‡ฌ๐Ÿ‡ง United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Amino Acid Sequence; Bacillus subtilis / enzymology; Bacterial Proteins / metabolism; Cloning, Molecular; DNA / chemistry; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / metabolism; Deoxyribonuclease I / chemistry; In Vitro Techniques; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Protein Binding; Sequence Homology, Amino Acid; Transcription Factors / metabolism
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Structure, binding interface and hydrophobic transitions of Ca2+-loaded calbindin-D-28K

Nature Structural & Molecular Biology, 13(7), 641โ€“647.

By: D. Kojetin, R. Venters, D. Kordys, R. Thompson, R. Kumar & J. Cavanagh

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Structure, binding interface and hydrophobic transitions of Ca2+-loaded calbindin-D28K

Nature Structural & Molecular Biology, 13(7), 641โ€“647.

By: D. Kojetinโ€‰ n, R. Ventersโ€‰*, D. Kordys n, R. Thompson n, R. Kumarโ€‰* & J. Cavanagh n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Amino Acid Sequence; Animals; Binding Sites; Calbindins; Calcium / metabolism; Cloning, Molecular; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Models, Molecular; Peptides / chemistry; Protein Folding; Protein Structure, Secondary; Rats; Recombinant Proteins / chemistry; Recombinant Proteins / metabolism; S100 Calcium Binding Protein G / chemistry; S100 Calcium Binding Protein G / metabolism
Source: Crossref
Added: August 28, 2020

2005 journal article

(4,2)D projection-reconstruction experiments for protein backbone assignment: Application to human carbonic anhydrase II and calbindin D-28K

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 127(24), 8785โ€“8795.

By: R. Ventersโ€‰ n, B. Coggins n, D. Kojetin n, J. Cavanagh n & P. Zhouโ€‰ n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Calbindins; Carbonic Anhydrase II / chemistry; Humans; Nuclear Magnetic Resonance, Biomolecular / methods; S100 Calcium Binding Protein G / chemistry
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Revised structure of the AbrB N-terminal domain unifies a diverse superfamily of putative DNA-binding proteins

FEBS LETTERS, 579(25), 5669โ€“5674.

By: B. Bobay n, A. Andreeva, G. Muellerโ€‰*, J. Cavanagh n & A. Murzin

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: NMR solution structure; protein-DNA interactions; structural genomics; structural classification of proteins
MeSH headings : Amino Acid Sequence; Bacillus subtilis / metabolism; Bacterial Proteins; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / classification; Dimerization; Escherichia coli Proteins / chemistry; Molecular Sequence Data; Protein Structure, Tertiary; Transcription Factors / chemistry; Transcription Factors / classification
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Solution structure and dynamics of LuxU from Vibrio harveyi, a phosphotransferase protein involved in bacterial quorum sensing

JOURNAL OF MOLECULAR BIOLOGY, 347(2), 297โ€“307.

By: D. Ulrich*, D. Kojetin n, B. Basslerโ€‰*, J. Cavanagh n & J. Loriaโ€‰*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: quorum-sensing; NMR; solution structure; LuxU; bioluminescence
MeSH headings : Amino Acid Sequence; Bacterial Proteins / chemistry; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Binding Sites; Models, Molecular; Molecular Sequence Data; Phosphoproteins / chemistry; Phosphoproteins / genetics; Phosphoproteins / metabolism; Protein Structure, Tertiary; Sequence Alignment; Sequence Homology, Amino Acid; Vibrio / metabolism
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Structural analysis of divalent metals binding to the Bacillus subtilis response regulator Spo0F: the possibility for In vitro metalloregulation in the initiation of sporulation

BIOMETALS, 18(5), 449โ€“466.

By: D. Kojetin n, R. Thompson n, L. Benson*, S. Naylor*, J. Waterman n, K. Daviesโ€‰*, C. Opperman n, K. Stephenson*, J. Hoch*, J. Cavanagh n

co-author countries: United Kingdom of Great Britain and Northern Ireland ๐Ÿ‡ฌ๐Ÿ‡ง United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: metal binding; NMR spectroscopy; response regulator; sporulation; two-component signal transduction
MeSH headings : Amino Acid Sequence; Bacillus subtilis / chemistry; Bacillus subtilis / physiology; Bacterial Proteins / chemistry; Bacterial Proteins / drug effects; Calcium / chemistry; Calcium / pharmacology; Copper / chemistry; Copper / pharmacology; Crystallography, X-Ray; In Vitro Techniques; Magnesium / chemistry; Magnesium / pharmacology; Magnetic Resonance Spectroscopy / methods; Magnetic Resonance Spectroscopy / standards; Manganese / chemistry; Manganese / pharmacology; Models, Molecular; Molecular Sequence Data; Phosphorylation / drug effects; Protein Binding; Protein Conformation; Protein Kinases / chemistry; Protein Kinases / drug effects; Reference Standards; Signal Transduction / drug effects; Signal Transduction / physiology; Spectrometry, Mass, Electrospray Ionization / methods; Spores, Bacterial / metabolism; Structure-Activity Relationship
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Evaluation of the DNA Binding Tendencies of the Transition State Regulator AbrBโ€ 

Biochemistry, 43(51), 16106โ€“16118.

By: B. Bobay n, L. Benson n, S. Naylor n, B. Feeney n, A. Clark n, M. Goshe n, M. Strauch n, R. Thompson n, J. Cavanagh n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Bacillus subtilis / metabolism; Circular Dichroism; DNA / chemistry; DNA / metabolism; Kinetics; Protein Binding / physiology; Spectrometry, Mass, Electrospray Ionization; Transcription Factors / chemistry; Transcription Factors / metabolism
Sources: Web Of Science, Crossref
Added: August 6, 2018

2004 journal article

H-1, N-15, and C-13 chemical shift assignments of the Vibrio harveyi histidine phosphotransferase protein LuxU

JOURNAL OF BIOMOLECULAR NMR, 29(4), 551โ€“552.

By: D. Ulrich*, R. Thompson n, B. Basslerโ€‰*, J. Cavanagh n & J. Loriaโ€‰*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Bacterial Proteins / chemistry; Carbon Isotopes; Hydrogen; Magnetic Resonance Spectroscopy; Nitrogen Isotopes; Phosphoproteins / chemistry; Vibrio / chemistry; Vibrio / enzymology
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Status of systems biology - does it have a future?

Drug Discovery Today: BIOSILICO, 2(5), 171โ€“174.

By: S. Naylor* & J. Cavanagh n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
Source: Crossref
Added: August 28, 2020

2004 article

Sub-classification of response regulators using the surface characteristics of their receiver domains (FEBS 27785) (vol 554, pg 231, 2003)

Kojetin, D. J., Thompson, R. J., & Cavanagh, J. (2004, February 27). FEBS LETTERS, Vol. 560, pp. 227โ€“228.

By: D. Kojetin*, R. Thompson* & J. Cavanagh*

Source: Web Of Science
Added: August 6, 2018

2003 journal article

Calbindin D-28K interacts with Ran-binding protein M: identification of interacting domains by NMR spectroscopy

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 303(4), 1186โ€“1192.

By: W. Lutz*, E. Frank*, T. Craig*, R. Thompson n, R. Ventersโ€‰*, D. Kojetin n, J. Cavanagh n, R. Kumarโ€‰*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Binding Sites; Calbindins; Cytoskeletal Proteins; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Nuclear Proteins / chemistry; Nuclear Proteins / metabolism; Precipitin Tests; Protein Structure, Tertiary; S100 Calcium Binding Protein G / chemistry; S100 Calcium Binding Protein G / metabolism; ran GTP-Binding Protein / chemistry; ran GTP-Binding Protein / metabolism
Source: Web Of Science
Added: August 6, 2018

2003 journal article

In-line desalting mass spectrometry for the study of noncovalent biological complexes

ANALYTICAL CHEMISTRY, 75(14), 3281โ€“3286.

By: J. Cavanagh n, L. Benson n, R. Thompson n & S. Naylor n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Biopolymers / chemistry; Chromatography, Gel; DNA / chemistry; Indicators and Reagents; Oligonucleotides / chemistry; Proteins / chemistry; RNA / chemistry; Spectrometry, Mass, Electrospray Ionization / methods
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Protein-metal ion interactions, stoichiometries and relative affinities determined by on-line size exclusion gel filtration mass spectrometry

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 17(4), 267โ€“271.

By: L. Benson*, R. Kumarโ€‰*, J. Cavanagh n & S. Naylor n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Animals; Brain Chemistry; Calbindins; Calcium / chemistry; Carrier Proteins / chemistry; Chromatography, Gel / methods; Magnesium / chemistry; Mass Spectrometry / methods; Metals / chemistry; Proteins / chemistry; Rats; S100 Calcium Binding Protein G / chemistry
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Sub-classification of response regulators using the surface characteristics of their receiver domains

FEBS LETTERS, 554(3), 231โ€“236.

By: D. Kojetin n, R. Thompson n & J. Cavanagh n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: OmpR sub-families; homology modeling
MeSH headings : Bacillus subtilis / chemistry; Bacillus subtilis / metabolism; Bacterial Proteins / chemistry; Bacterial Proteins / classification; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Escherichia coli / chemistry; Escherichia coli / metabolism; Genes, Regulator; Histidine Kinase; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Protein Kinases / genetics; Protein Kinases / metabolism; Protein Structure, Secondary; Protein Structure, Tertiary; Structural Homology, Protein; Trans-Activators / chemistry; Trans-Activators / classification; Trans-Activators / genetics
Source: Web Of Science
Added: August 6, 2018

2003 journal article

The effects of Ca2+ binding on the conformation of calbindin D-28K: A nuclear magnetic resonance and microelectrospray mass spectrometry study

ANALYTICAL BIOCHEMISTRY, 317(1), 59โ€“66.

By: R. Ventersโ€‰*, L. Benson*, T. Craig*, K. Paul n, D. Kordys n, R. Thompson n, S. Naylor*, R. Kumarโ€‰*, J. Cavanagh n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: calbindin D-28K; EF-hand; conformational response to calcium binding
MeSH headings : Apoproteins / chemistry; Calbindins; Calcium / metabolism; EF Hand Motifs; Escherichia coli Proteins / chemistry; Escherichia coli Proteins / genetics; Escherichia coli Proteins / metabolism; Molecular Weight; Nitrogen Isotopes; Nuclear Magnetic Resonance, Biomolecular / methods; Protein Binding; Recombinant Fusion Proteins / chemistry; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / metabolism; S100 Calcium Binding Protein G / chemistry; S100 Calcium Binding Protein G / genetics; S100 Calcium Binding Protein G / metabolism; Spectrometry, Mass, Electrospray Ionization / methods
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Alternative splicing of a beta(4) subunit proline-rich motif regulates voltage-dependent gating and toxin block of Ca(v)2.1 Ca2+ channels

Journal of Neuroscience, 22(21), 9331โ€“9339.

By: T. Helton*, D. Kojetin n, J. Cavanagh n & W. Horne*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Alternative Splicing / physiology; Amino Acid Motifs / physiology; Animals; Brain / metabolism; Calcium Channel Blockers / pharmacology; Calcium Channels, N-Type / drug effects; Calcium Channels, N-Type / genetics; Calcium Channels, N-Type / metabolism; Humans; Ion Channel Gating / drug effects; Ion Channel Gating / physiology; Membrane Potentials / physiology; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Nerve Tissue Proteins / genetics; Oocytes / metabolism; Organ Specificity; Patch-Clamp Techniques; Protein Structure, Tertiary / physiology; Protein Subunits / drug effects; Protein Subunits / genetics; Protein Subunits / metabolism; RNA, Messenger / metabolism; Sequence Deletion; Sequence Homology, Amino Acid; Spinal Cord / metabolism; Structure-Activity Relationship; Xenopus laevis; omega-Conotoxins / pharmacology
Source: NC State University Libraries
Added: August 6, 2018

2002 journal article

Current approaches for the study of large proteins by NMR

JOURNAL OF MOLECULAR STRUCTURE, 602, 275โ€“292.

By: R. Ventersโ€‰*, R. Thompson n & J. Cavanagh n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: NMR; large proteins; structure; methods
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Macromolecular assembly of the transition state regulator AbrB in its unbound and complexed states probed by microelectrospray ionization mass spectrometry

ANALYTICAL BIOCHEMISTRY, 306(2), 222โ€“227.

By: L. Benson*, J. Vaughn*, M. Strauch*, B. Bobay n, R. Thompson n, S. Naylor*, J. Cavanagh n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: AbrB; transition-state regulator; macromolecular assembly; mass spectrometry
MeSH headings : Bacillus subtilis; Bacterial Proteins / chemistry; Bacterial Proteins / metabolism; Chromatography, Gel; DNA / metabolism; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / metabolism; Escherichia coli; Macromolecular Substances; Protein Binding; Recombinant Proteins / chemistry; Recombinant Proteins / metabolism; Spectrometry, Mass, Electrospray Ionization; Transcription Factors / chemistry; Transcription Factors / metabolism
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Stoichiometries of protein - Protein/DNA binding and conformational changes for the transition-state regulator AbrB measured by pseudo cell-size exclusion chromatography-mass spectrometry

BIOCHEMISTRY, 41(25), 7859โ€“7865.

By: J. Cavanagh n, R. Thompson n, B. Bobay n, L. Benson n & S. Naylor n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Bacillus subtilis / chemistry; Bacterial Proteins / chemistry; Chromatography, Gel / instrumentation; Chromatography, Gel / methods; DNA / chemistry; DNA-Binding Proteins / chemistry; Electron Transport; Electron-Transferring Flavoproteins; Flavoproteins / chemistry; Geobacillus stearothermophilus / chemistry; Humans; Mass Spectrometry / instrumentation; Mass Spectrometry / methods; Protein Binding; Protein Conformation; Spectrometry, Mass, Electrospray Ionization / instrumentation; Spectrometry, Mass, Electrospray Ionization / methods; Transcription Factors / chemistry
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Structural and catalytic response to temperature and cosolvents of carboxylesterase EST1 from the extremely thermoacidophilic archaeon Sulfolobus solfataricus P1

BIOTECHNOLOGY AND BIOENGINEERING, 80(7), 784โ€“793.

By: A. Sehgal n, R. Tompson n, J. Cavanagh n & R. Kelly nโ€‰

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: DMSO; conformational flexibility; enzyme activation; thermostable
MeSH headings : Acetonitriles / chemistry; Carboxylesterase; Carboxylic Ester Hydrolases / biosynthesis; Carboxylic Ester Hydrolases / chemistry; Carboxylic Ester Hydrolases / isolation & purification; Catalysis; Dimethyl Sulfoxide / chemistry; Dimethylformamide / chemistry; Dioxanes / chemistry; Enzyme Activation; Enzyme Stability; Molecular Conformation; Quality Control; Sensitivity and Specificity; Solvents / chemistry; Species Specificity; Structure-Activity Relationship; Sulfolobus / classification; Sulfolobus / enzymology; Temperature
Sources: Web Of Science, ORCID
Added: August 6, 2018

2001 article

Protein dynamic studies move to a new time slot

Cavanagh, J., & Venters, R. A. (2001, November). NATURE STRUCTURAL BIOLOGY, Vol. 8, pp. 912โ€“914.

By: J. Cavanagh n & R. Ventersโ€‰*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Amino Acid Substitution / genetics; Bacteriophage T4 / enzymology; Bacteriophage T4 / genetics; Entropy; Kinetics; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Motion; Muramidase / chemistry; Muramidase / genetics; Muramidase / metabolism; Protein Conformation; Protein Folding; Proteins / chemistry; Proteins / genetics; Proteins / metabolism
Source: Web Of Science
Added: August 6, 2018

2001 journal article

The DNA-binding domain in the Bacillus subtilis transition-state regulator AbrB employs significant motion for promiscuous DNA recognition

JOURNAL OF MOLECULAR BIOLOGY, 305(3), 429โ€“439.

By: J. Vaughn*, V. Feher*, C. Bracken* & J. Cavanagh*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: dynamics; AbrB; transition-state regulator; DNA-binding
MeSH headings : Amino Acid Sequence; Bacillus subtilis / chemistry; Bacterial Proteins; Binding Sites; DNA / chemistry; DNA / genetics; DNA / metabolism; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / metabolism; Kinetics; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Motion; Nucleic Acid Conformation; Pliability; Protein Structure, Secondary; Protein Structure, Tertiary; Static Electricity; Substrate Specificity; Thermodynamics; Transcription Factors / chemistry; Transcription Factors / metabolism
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Novel DNA binding domain and genetic regulation model of Bacillus subtilis transition state regulator AbrB

Nature Structural Biology, 7(12), 1139โ€“1146.

By: J. Vaughn, V. Feher, S. Naylor, M. Strauch & J. Cavanagh

Source: NC State University Libraries
Added: August 6, 2018

1995 journal article

Functional implications of the structure of the bacterial response regulator Spo0F

Journal of Cellular Biochemistry, Suppl. 21B, 25.

By: V. Feher, J. Zapf, J. Hoch, J. Whiteley, J. Cavanagh & D. W.

Source: NC State University Libraries
Added: August 6, 2018

1993 journal article

Solution structure of the Bacillus subtilis glucose permease Iia domain and its interaction with another phosphocarrier protein Hpr. J

Journal of Cellular Biochemistry, Suppl. 17C, 271.

John Cavanagh

Source: NC State University Libraries
Added: August 6, 2018

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