John Cavanagh

The Solution Structures and Interaction of SinR and SinI: Elucidating the Mechanism of Action of the Master Regulator Switch for Biofilm Formation in Bacillus subtilis

JOURNAL OF MOLECULAR BIOLOGY, 432(2), 343–357.

Re-sensitizing Multidrug Resistant Bacteria to Antibiotics by Targeting Bacterial Response Regulators: Characterization and Comparison of Interactions between 2-Aminoimidazoles and the Response Regulators BfmR from Acinetobacter baumannii and QseB from Francisella spp.

FRONTIERS IN MOLECULAR BIOSCIENCES, 5.

The Structure of the Biofilm-controlling Response Regulator BfmR from Acinetobacter baumannii Reveals Details of Its DNA-binding Mechanism

Journal of Molecular Biology, 430(6), 806–821.

Evaluation of a 2-aminoimidazole variant as adjuvant treatment for dermal bacterial infections

Drug Design Development and Therapy, 11, 153–162.

Potentiation of Francisella resistance to conventional antibiotics through small molecule adjuvants

MEDCHEMCOMM, 7(1), 128–131.

Augmenting anti-cancer natural products with a small molecule adjuvant

Marine Drugs, 13(1), 65–75.

Membrane-Permeabilizing Activity of Reverse-Amide 2-Aminoimidazole Antibiofilm Agents Against Acinetobacter baumannii

CURRENT DRUG DELIVERY, 12(2), 223–230.

Teaching old drugs new tricks: Addressing resistance in Francisella

Feldmann, E. A., & Cavanagh, J. (2015, July 4). VIRULENCE, Vol. 6, pp. 414–416.

A DNA Mimic: The Structure and Mechanism of Action for the Anti-Repressor Protein AbbA

JOURNAL OF MOLECULAR BIOLOGY, 426(9), 1911–1924.

Chemical shift assignments and secondary structure prediction of the C-terminal domain of the response regulator BfmR from Acinetobacter baumannii

BIOMOLECULAR NMR ASSIGNMENTS, 8(1), 67–70.

Chemical shift assignments and secondary structure prediction of the master biofilm regulator, SinR, from Bacillus subtilis

BIOMOLECULAR NMR ASSIGNMENTS, 8(1), 155–158.

Chemical shift assignments and secondary structure prediction of the phosphorelay protein VanU from Vibrio anguillarum

BIOMOLECULAR NMR ASSIGNMENTS, 8(1), 177–179.

Small-Molecule Suppression of beta-Lactam Resistance in Multidrug-Resistant Gram-Negative Pathogens

JOURNAL OF MEDICINAL CHEMISTRY, 57(17), 7450–7458.

Structure and DNA-Binding Traits of the Transition State Regulator AbrB

STRUCTURE, 22(11), 1650–1656.

Chemical crosslinking and LC/MS analysis to determine protein domain orientation: Application to AbrB

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 431(2), 253–257.

Evaluation of the toxicity of 2-aminoimidazole antibiofilm agents using both cellular and model organism systems

DRUG AND CHEMICAL TOXICOLOGY, 35(3), 310–315.

H-1, C-13, and N-15 resonance assignments and secondary structure prediction of the full-length transition state regulator AbrB from Bacillus anthracis

BIOMOLECULAR NMR ASSIGNMENTS, 6(1), 95–98.

Identification of BfmR, a Response Regulator Involved in Biofilm Development, as a Target for a 2-Aminoimidazole-Based Antibiofilm Agent

BIOCHEMISTRY, 51(49), 9776–9778.

Structural insights into the calcium-dependent interaction between calbindin-D28K and caspase-3

FEBS LETTERS, 586(20), 3582–3589.

Anti-biofilm compounds derived from marine sponges

[Review of ]. Marine Drugs, 9(10), 2010–2035.

Flustramine inspired synthesis and biological evaluation of pyrroloindoline triazole amides as novel inhibitors of bacterial biofilms

ORGANIC & BIOMOLECULAR CHEMISTRY, 9(15), 5476–5481.

Intercepting Bacterial Indole Signaling with Flustramine Derivatives

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 133(50), 20160–20163.

Observing selected domains in multi-domain proteins via sortase-mediated ligation and NMR spectroscopy

JOURNAL OF BIOMOLECULAR NMR, 49(1), 3–7.

Binding site on human immunoglobulin G for the affinity ligand HWRGWV

Journal of Molecular Recognition, 23(3), 271–282.

Long range dynamic effects of point-mutations trap a response regulator in an active conformation

FEBS LETTERS, 584(19), 4203–4207.

NMR Solution Structure and DNA-binding Model of the DNA-binding Domain of Competence Protein A

JOURNAL OF MOLECULAR BIOLOGY, 398(2), 248–263.

Synergistic Effects between Conventional Antibiotics and 2-Aminoimidazole-Derived Antibiofilm Agents

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 54(5), 2112–2118.

Amide Isosteres of Oroidin: Assessment of Antibiofilm Activity and C. elegans Toxicity

JOURNAL OF MEDICINAL CHEMISTRY, 52(15), 4582–4585.

Binding site on human immunoglobulin G for the affinity ligand HWRGWV

Journal of Molecular Recognition, n/a-n/a.

Evaluation of dihydrooroidin as an antifouling additive in marine paint

INTERNATIONAL BIODETERIORATION & BIODEGRADATION, 63(4), 529–532.

Structural Characterization of the Conformational Change in Calbindin-D-28k upon Calcium Binding Using Differential Surface Modification Analyzed by Mass Spectrometry

BIOCHEMISTRY, 48(36), 8603–8614.

Structural and Motional Contributions of the Bacillus subtilis ClpC N-Domain to Adaptor Protein Interactions

JOURNAL OF MOLECULAR BIOLOGY, 387(3), 639–652.

Co-Evolving Motions at Protein−Protein Interfaces of Two-Component Signaling Systems Identified by Covariance Analysis†

Biochemistry, 47(30), 7782–7784.

Control of bacterial biofilms with marine alkaloid derivatives

MOLECULAR BIOSYSTEMS, 4(6), 614–621.

Inhibition and dispersion of proteobacterial biofilms

Chemical Communications, (14), 1698.

Insights into the Nature of DNA Binding of AbrB-like Transcription Factors

STRUCTURE, 16(11), 1702–1713.

Targeting RNA with cysteine-constrained peptides

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 18(2), 565–567.

Abh and AbrB control of Bacillus subtilis antimicrobial gene expression

JOURNAL OF BACTERIOLOGY, 189(21), 7720–7732.

NMR assignment of the N-terminal repeat domain of Bacillus subtilis ClpC

BIOMOLECULAR NMR ASSIGNMENTS, 1(2), 163–165.

Peptide binding proclivities of calcium loaded calbindin-D28k

FEBS LETTERS, 581(24), 4778–4782.

Predominantly buried residues in the response regulator Spo0F influence specific sensor kinase recognition

FEBS LETTERS, 581(7), 1425–1429.

Tandem mass spectrometry acquisition approaches to enhance identification of protein-protein interactions using low-energy collision-induced dissociative chemical crosslinking reagents

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 21(21), 3395–3408.

Measurement of multisite oxidation kinetics reveals an active site conformational change in Spo0F as a result of protein oxidation

BIOCHEMISTRY, 45(20), 6260–6266.

NMR structure of AbhN and comparison with AbrBN - First insights into the DNA binding promiscuity and specificity of AbrB-like transition state regulator proteins

JOURNAL OF BIOLOGICAL CHEMISTRY, 281(30), 21399–21409.

Structure, binding interface and hydrophobic transitions of Ca2+-loaded calbindin-D-28K

Nature Structural & Molecular Biology, 13(7), 641–647.

Structure, binding interface and hydrophobic transitions of Ca2+-loaded calbindin-D28K

Nature Structural & Molecular Biology, 13(7), 641–647.

(4,2)D projection-reconstruction experiments for protein backbone assignment: Application to human carbonic anhydrase II and calbindin D-28K

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 127(24), 8785–8795.

Revised structure of the AbrB N-terminal domain unifies a diverse superfamily of putative DNA-binding proteins

FEBS LETTERS, 579(25), 5669–5674.

Solution structure and dynamics of LuxU from Vibrio harveyi, a phosphotransferase protein involved in bacterial quorum sensing

JOURNAL OF MOLECULAR BIOLOGY, 347(2), 297–307.

Structural analysis of divalent metals binding to the Bacillus subtilis response regulator Spo0F: the possibility for In vitro metalloregulation in the initiation of sporulation

BIOMETALS, 18(5), 449–466.

Evaluation of the DNA Binding Tendencies of the Transition State Regulator AbrB†

Biochemistry, 43(51), 16106–16118.

H-1, N-15, and C-13 chemical shift assignments of the Vibrio harveyi histidine phosphotransferase protein LuxU

JOURNAL OF BIOMOLECULAR NMR, 29(4), 551–552.

Status of systems biology - does it have a future?

Drug Discovery Today: BIOSILICO, 2(5), 171–174.

Sub-classification of response regulators using the surface characteristics of their receiver domains (FEBS 27785) (vol 554, pg 231, 2003)

Kojetin, D. J., Thompson, R. J., & Cavanagh, J. (2004, February 27). FEBS LETTERS, Vol. 560, pp. 227–228.

Calbindin D-28K interacts with Ran-binding protein M: identification of interacting domains by NMR spectroscopy

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 303(4), 1186–1192.

In-line desalting mass spectrometry for the study of noncovalent biological complexes

ANALYTICAL CHEMISTRY, 75(14), 3281–3286.

Protein-metal ion interactions, stoichiometries and relative affinities determined by on-line size exclusion gel filtration mass spectrometry

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 17(4), 267–271.

Sub-classification of response regulators using the surface characteristics of their receiver domains

FEBS LETTERS, 554(3), 231–236.

The effects of Ca2+ binding on the conformation of calbindin D-28K: A nuclear magnetic resonance and microelectrospray mass spectrometry study

ANALYTICAL BIOCHEMISTRY, 317(1), 59–66.

Alternative splicing of a beta(4) subunit proline-rich motif regulates voltage-dependent gating and toxin block of Ca(v)2.1 Ca2+ channels

Journal of Neuroscience, 22(21), 9331–9339.

Current approaches for the study of large proteins by NMR

JOURNAL OF MOLECULAR STRUCTURE, 602, 275–292.

Macromolecular assembly of the transition state regulator AbrB in its unbound and complexed states probed by microelectrospray ionization mass spectrometry

ANALYTICAL BIOCHEMISTRY, 306(2), 222–227.

Stoichiometries of protein - Protein/DNA binding and conformational changes for the transition-state regulator AbrB measured by pseudo cell-size exclusion chromatography-mass spectrometry

BIOCHEMISTRY, 41(25), 7859–7865.

Structural and catalytic response to temperature and cosolvents of carboxylesterase EST1 from the extremely thermoacidophilic archaeon Sulfolobus solfataricus P1

BIOTECHNOLOGY AND BIOENGINEERING, 80(7), 784–793.

Protein dynamic studies move to a new time slot

Cavanagh, J., & Venters, R. A. (2001, November). NATURE STRUCTURAL BIOLOGY, Vol. 8, pp. 912–914.

The DNA-binding domain in the Bacillus subtilis transition-state regulator AbrB employs significant motion for promiscuous DNA recognition

JOURNAL OF MOLECULAR BIOLOGY, 305(3), 429–439.

Novel DNA binding domain and genetic regulation model of Bacillus subtilis transition state regulator AbrB

Nature Structural Biology, 7(12), 1139–1146.

Functional implications of the structure of the bacterial response regulator Spo0F

Journal of Cellular Biochemistry, Suppl. 21B, 25.

Solution structure of the Bacillus subtilis glucose permease Iia domain and its interaction with another phosphocarrier protein Hpr. J

Journal of Cellular Biochemistry, Suppl. 17C, 271.