John Cavanagh

The Solution Structures and Interaction of SinR and SinI: Elucidating the Mechanism of Action of the Master Regulator Switch for Biofilm Formation in Bacillus subtilis

Milton, M. E., Draughn, G. L., Bobay, B. G., Stowe, S. D., Olson, A. L., Feldmann, E. A., … Cavanagh, J. (2019, September 5). Journal of Molecular Biology.

Re-sensitizing Multidrug Resistant Bacteria to Antibiotics by Targeting Bacterial Response Regulators: Characterization and Comparison of Interactions between 2-Aminoimidazoles and the Response Regulators BfmR from Acinetobacter baumannii and QseB from Francisella spp.

Milton, M. E., Minrovic, B. M., Harris, D. L., Kang, B., Jung, D., Lewis, C. P., … Cavanagh, J. (2018, February 13). Frontiers in Molecular Biosciences.

The Structure of the Biofilm-controlling Response Regulator BfmR from Acinetobacter baumannii Reveals Details of Its DNA-binding Mechanism

Journal of Molecular Biology, 430(6), 806–821.

Evaluation of a 2-aminoimidazole variant as adjuvant treatment for dermal bacterial infections

Drug Design Development and Therapy, 11, 153–162.

Augmenting anti-cancer natural products with a small molecule adjuvant

Marine Drugs, 13(1), 65–75.

Membrane-Permeabilizing Activity of Reverse-Amide 2-Aminoimidazole Antibiofilm Agents Against Acinetobacter baumannii

Stowe, S., Thompson, R., Peng, L., Su, Z., Blackledge, M., Draughn, G., … Cavanagh, J. (2015, April 23). Current Drug Delivery.

Potentiation of Francisella resistance to conventional antibiotics through small molecule adjuvants

Stephens, M. D., Hubble, V. B., Ernst, R. K., Hoek, M. L., Melander, R. J., Cavanagh, J., & Melander, C. (2015, September 30). MedChemComm.

Teaching old drugs new tricks: Addressing resistance inFrancisella

Feldmann, E. A., & Cavanagh, J. (2015, June 9). Virulence.

A DNA Mimic: The Structure and Mechanism of Action for the Anti-Repressor Protein AbbA

Tucker, A. T., Bobay, B. G., Banse, A. V., Olson, A. L., Soderblom, E. J., Moseley, M. A., … Cavanagh, J. (2014, February 15). Journal of Molecular Biology.

Small-Molecule Suppression of β-Lactam Resistance in Multidrug-Resistant Gram-Negative Pathogens

Brackett, C. M., Melander, R. J., An, I. H., Krishnamurthy, A., Thompson, R. J., Cavanagh, J., & Melander, C. (2014, August 19). Journal of Medicinal Chemistry.

Structure and DNA-Binding Traits of the Transition State Regulator AbrB

Olson, A. L., Tucker, A. T., Bobay, B. G., Soderblom, E. J., Moseley, M. A., Thompson, R. J., & Cavanagh, J. (2014, October 9). Structure.

Chemical crosslinking and LC/MS analysis to determine protein domain orientation: Application to AbrB

Olson, A. L., Liu, F., Tucker, A. T., Goshe, M. B., & Cavanagh, J. (2013, January 9). Biochemical and Biophysical Research Communications.

Chemical shift assignments and secondary structure prediction of the master biofilm regulator, SinR, from Bacillus subtilis

Stowe, S. D., Olson, A. L., Losick, R., & Cavanagh, J. (2013, March 9). Biomolecular NMR Assignments.

Chemical shift assignments and secondary structure prediction of the phosphorelay protein VanU from Vibrio anguillarum

Bobay, B. G., Thompson, R. J., Milton, D. L., & Cavanagh, J. (2013, April 20). Biomolecular NMR Assignments.

Chemical shift assignments and secondary structure prediction of the C-terminal domain of the response regulator BfmR from Acinetobacter baumannii

Olson, A. L., Thompson, R. J., Melander, C., & Cavanagh, J. (2012, December 20). Biomolecular NMR Assignments.

Evaluation of the toxicity of 2-aminoimidazole antibiofilm agents using both cellular and model organism systems

Stowe, S. D., Tucker, A. T., Thompson, R., Piper, A., Richards, J. J., Rogers, S. A., … Cavanagh, J. (2012, January 31). Drug and Chemical Toxicology.

Identification of BfmR, a Response Regulator Involved in Biofilm Development, as a Target for a 2-Aminoimidazole-Based Antibiofilm Agent

Thompson, R. J., Bobay, B. G., Stowe, S. D., Olson, A. L., Peng, L., Su, Z., … Cavanagh, J. (2012, November 27). Biochemistry.

Structural insights into the calcium‐dependent interaction between calbindin‐D28K and caspase‐3

Bobay, B. G., Stewart, A. L., Tucker, A. T., Thompson, R. J., Varney, K. M., & Cavanagh, J. (2012, September 13). FEBS Letters.

1H, 13C, and 15N resonance assignments and secondary structure prediction of the full-length transition state regulator AbrB from Bacillus anthracis

Olson, A. L., Bobay, B. G., Melander, C., & Cavanagh, J. (2011, August 3). Biomolecular NMR Assignments.

Anti-biofilm compounds derived from marine sponges

[Review of ]. Marine Drugs, 9(10), 2010–2035.

Flustramine inspired synthesis and biological evaluation of pyrroloindoline triazole amides as novel inhibitors of bacterial biofilms

Bunders, C., Cavanagh, J., & Melander, C. (2011, January 1). Organic & Biomolecular Chemistry.

Intercepting Bacterial Indole Signaling with Flustramine Derivatives

Bunders, C. A., Minvielle, M. J., Worthington, R. J., Ortiz, M., Cavanagh, J., & Melander, C. (2011, November 17). Journal of the American Chemical Society.

Binding site on human immunoglobulin G for the affinity ligand HWRGWV

Journal of Molecular Recognition, n/a-n/a.

Binding site on human immunoglobulin G for the affinity ligand HWRGWV

Journal of Molecular Recognition, 23(3), 271–282.

Long range dynamic effects of point‐mutations trap a response regulator in an active conformation

Bobay, B. G., Thompson, R. J., Hoch, J. A., & Cavanagh, J. (2010, September 7). FEBS Letters.

NMR Solution Structure and DNA-binding Model of the DNA-binding Domain of Competence Protein A

Hobbs, C. A., Bobay, B. G., Thompson, R. J., Perego, M., & Cavanagh, J. (2010, March 18). Journal of Molecular Biology.

Observing selected domains in multi-domain proteins via sortase-mediated ligation and NMR spectroscopy

Refaei, M. A., Combs, A., Kojetin, D. J., Cavanagh, J., Caperelli, C., Rance, M., … Tsang, P. (2010, December 28). Journal of Biomolecular NMR.

Synergistic Effects between Conventional Antibiotics and 2-Aminoimidazole-Derived Antibiofilm Agents

Rogers, S. A., Huigens, R. W., Cavanagh, J., & Melander, C. (2010, March 9). Antimicrobial Agents and Chemotherapy.

Amide Isosteres of Oroidin: Assessment of Antibiofilm Activity and C. elegans Toxicity

Richards, J. J., Reyes, S., Stowe, S. D., Tucker, A. T., Ballard, T. E., Mathies, L. D., … Melander, C. (2009, July 9). Journal of Medicinal Chemistry.

Evaluation of dihydrooroidin as an antifouling additive in marine paint

Melander, C., Moeller, P. D. R., Ballard, T. E., Richards, J. J., Huigens, R. W., & Cavanagh, J. (2009, February 10). International Biodeterioration & Biodegradation.

Structural Characterization of the Conformational Change in Calbindin-D_28k upon Calcium Binding Using Differential Surface Modification Analyzed by Mass Spectrometry

Hobbs, C. A., Deterding, L. J., Perera, L., Bobay, B. G., Thompson, R. J., Darden, T. A., … Tomer, K. B. (2009, August 6). Biochemistry.

Structural and Motional Contributions of the Bacillus subtilis ClpC N-Domain to Adaptor Protein Interactions

Kojetin, D. J., McLaughlin, P. D., Thompson, R. J., Dubnau, D., Prepiak, P., Rance, M., & Cavanagh, J. (2009, January 31). Journal of Molecular Biology.

Co-Evolving Motions at Protein−Protein Interfaces of Two-Component Signaling Systems Identified by Covariance Analysis†

Biochemistry, 47(30), 7782–7784.

Control of bacterial biofilms with marine alkaloid derivatives

Huigens, R. W., III, Ma, L., Gambino, C., Moeller, P. D. R., Basso, A., Cavanagh, J., … Melander, C. (2008, February 21). Molecular BioSystems.

Inhibition and dispersion of proteobacterial biofilms

Chemical Communications, (14), 1698.

Insights into the Nature of DNA Binding of AbrB-like Transcription Factors

Sullivan, D. M., Bobay, B. G., Kojetin, D. J., Thompson, R. J., Rance, M., Strauch, M. A., & Cavanagh, J. (2008, November 1). Structure.

Abh and AbrB Control of Bacillus subtilis Antimicrobial Gene Expression

Strauch, M. A., Bobay, B. G., Cavanagh, J., Yao, F., Wilson, A., & Breton, Y. L. (2007, August 25). Journal of Bacteriology.

NMR assignment of the N-terminal repeat domain of Bacillus subtilis ClpC

Kojetin, D. J., McLaughlin, P. D., Thompson, R. J., Venters, R. A., Rance, M., & Cavanagh, J. (2007, September 5). Biomolecular NMR Assignments.

Peptide binding proclivities of calcium loaded calbindin‐D28k

Kordys, D. R., Bobay, B. G., Thompson, R. J., Venters, R. A., & Cavanagh, J. (2007, September 11). FEBS Letters.

Predominantly buried residues in the response regulator Spo0F influence specific sensor kinase recognition

McLaughlin, P. D., Bobay, B. G., Regel, E. J., Thompson, R. J., Hoch, J. A., & Cavanagh, J. (2007, March 5). FEBS Letters.

Tandem mass spectrometry acquisition approaches to enhance identification of protein‐protein interactions using low‐energy collision‐induced dissociative chemical crosslinking reagents

Soderblom, E. J., Bobay, B. G., Cavanagh, J., & Goshe, M. B. (2007, September 28). Rapid Communications in Mass Spectrometry.

Targeting RNA with cysteine-constrained peptides

Burns, V. A., Bobay, B. G., Basso, A., Cavanagh, J., & Melander, C. (2007, December 5). Bioorganic & Medicinal Chemistry Letters.

Measurement of Multisite Oxidation Kinetics Reveals an Active Site Conformational Change in Spo0F as a Result of Protein Oxidation

Sharp, J. S., Sullivan, D. M., Cavanagh, J., & Tomer, K. B. (2006, May 1). Biochemistry.

NMR Structure of AbhN and Comparison with AbrBN

Bobay, B. G., Mueller, G. A., Thompson, R. J., Murzin, A. G., Venters, R. A., Strauch, M. A., & Cavanagh, J. (2006, May 16). Journal of Biological Chemistry.

Structure, binding interface and hydrophobic transitions of Ca2+-loaded calbindin-D-28K

Structure, binding interface and hydrophobic transitions of Ca2+-loaded calbindin-D28K

Nature Structural & Molecular Biology, 13(7), 641–647.

(4,2)D Projection−Reconstruction Experiments for Protein Backbone Assignment:  Application to Human Carbonic Anhydrase II and Calbindin D_28K

Venters, R. A., Coggins, B. E., Kojetin, D., Cavanagh, J., & Zhou, P. (2005, May 25). Journal of the American Chemical Society.

Revised structure of the AbrB N‐terminal domain unifies a diverse superfamily of putative DNA‐binding proteins

Bobay, B. G., Andreeva, A., Mueller, G. A., Cavanagh, J., & Murzin, A. G. (2005, October 4). FEBS Letters.

Solution Structure and Dynamics of LuxU from Vibrio harveyi, a Phosphotransferase Protein Involved in Bacterial Quorum Sensing

Ulrich, D. L., Kojetin, D., Bassler, B. L., Cavanagh, J., & Loria, J. P. (2005, February 1). Journal of Molecular Biology.

Structural Analysis of Divalent Metals Binding to the Bacillus subtilis Response Regulator Spo0F: The Possibility for In Vitro Metalloregulation in the Initiation of Sporulation

Kojetin, D. J., Thompson, R. J., Benson, L. M., Naylor, S., Waterman, J., Davies, K. G., … Cavanagh, J. (2005, October 1). BioMetals.

Corrigendum to: Sub‐classification of response regulators using the surface characteristics of their receiver domains (FEBS 27785)

Kojetin, D. J., Thompson, R. J., & Cavanagh, J. (2004, February 4). FEBS Letters.

Evaluation of the DNA Binding Tendencies of the Transition State Regulator AbrB†

Biochemistry, 43(51), 16106–16118.

Letter to the Editor: 1H, 15N, and 13C chemical shift assignments of the Vibrio harveyi histidine phosphotransferase protein LuxU

Ulrich, D. L., Thompson, R., Bassler, B., Cavanagh, J., & Loria, J. P. (2004, July 9). Journal of Biomolecular NMR.

Status of systems biology - does it have a future?

Drug Discovery Today: BIOSILICO, 2(5), 171–174.

Calbindin D28K interacts with Ran-binding protein M: identification of interacting domains by NMR spectroscopy

Lutz, W., Frank, E. M., Craig, T. A., Thompson, R., Venters, R. A., Kojetin, D., … Kumar, R. (2003, April 1). Biochemical and Biophysical Research Communications.

In-Line Desalting Mass Spectrometry for the Study of Noncovalent Biological Complexes

Cavanagh, J., Benson, L. M., Thompson, R., & Naylor, S. (2003, June 12). Analytical Chemistry.

Protein‐metal ion interactions, stoichiometries and relative affinities determined by on‐line size exclusion gel filtration mass spectrometry

Benson, L. M., Kumar, R., Cavanagh, J., & Naylor, S. (2003, January 3). Rapid Communications in Mass Spectrometry.

Sub‐classification of response regulators using the surface characteristics of their receiver domains

Kojetin, D. J., Thompson, R. J., & Cavanagh, J. (2003, October 21). FEBS Letters.

The effects of Ca2+ binding on the conformation of calbindin D28K: A nuclear magnetic resonance and microelectrospray mass spectrometry study

Venters, R. A., Benson, L. M., Craig, T. A., Paul, K. H., Kordys, D. R., Thompson, R., … Cavanagh, J. (2003, April 30). Analytical Biochemistry.

Alternative Splicing of a β₄Subunit Proline-Rich Motif Regulates Voltage-Dependent Gating and Toxin Block of Ca_v2.1 Ca²⁺Channels

Helton, T. D., Kojetin, D. J., Cavanagh, J., & Horne, W. A. (2002, November 1). Journal of Neuroscience.

Current approaches for the study of large proteins by NMR

Venters, R. A., Thompson, R., & Cavanagh, J. (2002, January 1). Journal of Molecular Structure.

Macromolecular Assembly of the Transition State Regulator AbrB in Its Unbound and Complexed States Probed by Microelectrospray Ionization Mass Spectrometry

Benson, L. M., Vaughn, J. L., Strauch, M. A., Bobay, B. G., Thompson, R., Naylor, S., & Cavanagh, J. (2002, July 1). Analytical Biochemistry.

Stoichiometries of Protein−Protein/DNA Binding and Conformational Changes for the Transition-State Regulator AbrB Measured by Pseudo Cell-Size Exclusion Chromatography−Mass Spectrometry

Cavanagh, J., Thompson, R., Bobay, B., Benson, L. M., & Naylor, S. (2002, June 1). Biochemistry.

Structural and catalytic response to temperature and cosolvents of carboxylesterase EST1 from the extremely thermoacidophilic archaeon Sulfolobus solfataricus P1

Sehgal, A. C., Tompson, R., Cavanagh, J., & Kelly, R. M. (2002, October 23). Biotechnology and Bioengineering, Vol. 80, pp. 784–793.

Protein dynamic studies move to a new time slot.

Cavanagh, J., & Venters, R. A. (2001, November 1). Nature Structural Biology.

The DNA-binding domain in the Bacillus subtilis transition-state regulator AbrB employs significant motion for promiscuous DNA recognition

Vaughn, J. L., Feher, V. A., Bracken, C., & Cavanagh, J. (2001, January 1). Journal of Molecular Biology.

Novel DNA binding domain and genetic regulation model of Bacillus subtilis transition state regulator AbrB

Nature Structural Biology, 7(12), 1139–1146.

Functional implications of the structure of the bacterial response regulator Spo0F

Journal of Cellular Biochemistry, Suppl. 21B, 25.

Solution structure of the Bacillus subtilis glucose permease Iia domain and its interaction with another phosphocarrier protein Hpr. J

Journal of Cellular Biochemistry, Suppl. 17C, 271.