Works (69)

2020 journal article

The Solution Structures and Interaction of SinR and Sinl: Elucidating the Mechanism of Action of the Master Regulator Switch for Biofilm Formation in Bacillus subtilis

JOURNAL OF MOLECULAR BIOLOGY, 432(2), 343–357.

By: M. Milton, G. Draughn, B. Bobay, S. Stowe, A. Olson, E. Feldmann, R. Thompson, K. Myers ...

Source: Web Of Science
Added: February 27, 2020

2018 journal article

Re-sensitizing Multidrug Resistant Bacteria to Antibiotics by Targeting Bacterial Response Regulators: Characterization and Comparison of Interactions between 2-Aminoimidazoles and the Response Regulators BfmR from Acinetobacter baumannii and QseB from Francisella spp.

FRONTIERS IN MOLECULAR BIOSCIENCES, 5.

By: M. Milton, B. Minrovic, D. Harris, B. Kang, D. Jung, C. Lewis, R. Thompson, R. Melander ...

Source: NC State University Libraries
Added: January 28, 2019

2018 journal article

The Structure of the Biofilm-controlling Response Regulator BfmR from Acinetobacter baumannii Reveals Details of Its DNA-binding Mechanism

Journal of Molecular Biology, 430(6), 806–821.

By: G. Draughn, M. Milton, E. Feldmann, B. Bobay, B. Roth, A. Olson, R. Thompson, L. Actis, C. Davies, J. Cavanagh

Source: Crossref
Added: February 24, 2020

2017 journal article

Evaluation of a 2-aminoimidazole variant as adjuvant treatment for dermal bacterial infections

Drug Design Development and Therapy, 11, 153–162.

By: G. Draughn, C. Allen, P. Routh, M. Stone, K. Kirker, A. Boegli, R. Schuchman, K. Linder ...

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Potentiation of Francisella resistance to conventional antibiotics through small molecule adjuvants

MedChemComm, 7(1), 128–131.

By: M. Stephens, V. Hubble, R. Ernst, M. Hoek, R. Melander, J. Cavanagh, C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Augmenting anti-cancer natural products with a small molecule adjuvant

Marine Drugs, 13(1), 65–75.

By: P. Wahome, K. Beauchesne, A. Pedone, J. Cavanagh, C. Melander, P. Zimba, P. Moeller

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Membrane-permeabilizing activity of reverse-amide 2-aminoimidazole antibiofilm agents against Acinetobacter baumannii

Current Drug Delivery, 12(2), 223–230.

By: S. Stowe, R. Thompson, L. Peng, Z. Su, M. Blackledge, G. Draughn, W. Coe, E. Johannes ...

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Teaching old drugs new tricks: Addressing resistance in Francisella

Virulence, 6(5), 414–416.

By: E. Feldmann & J. Cavanagh

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

A DNA Mimic: The Structure and Mechanism of Action for the Anti-Repressor Protein AbbA

Journal of Molecular Biology, 426(9), 1911–1924.

By: A. Tucker, B. Bobay, A. Banse, A. Olson, E. Soderblom, M. Moseley, R. Thompson, K. Varney, R. Losick, J. Cavanagh

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Chemical shift assignments and secondary structure prediction of the C-terminal domain of the response regulator BfmR from Acinetobacter baumannii

Biomolecular NMR Assignments, 8(1), 67–70.

By: A. Olson, R. Thompson, C. Melander & J. Cavanagh

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Chemical shift assignments and secondary structure prediction of the master biofilm regulator, SinR, from Bacillus subtilis

Biomolecular NMR Assignments, 8(1), 155–158.

By: S. Stowe, A. Olson, R. Losick & J. Cavanagh

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Chemical shift assignments and secondary structure prediction of the phosphorelay protein VanU from Vibrio anguillarum

Biomolecular NMR Assignments, 8(1), 177–179.

By: B. Bobay, R. Thompson, D. Milton & J. Cavanagh

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Small-molecule suppression of beta-lactam resistance in multidrug-resistant gram-negative pathogens

Journal of Medicinal Chemistry, 57(17), 7450–7458.

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Structure and DNA-binding traits of the transition state regulator AbrB

Structure (Cambridge, Mass. : 2001), 22(11), 1650–1656.

By: A. Olson, A. Tucker, B. Bobay, E. Soderblom, M. Moseley, R. Thompson, J. Cavanagh

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

Chemical crosslinking and LC/MS analysis to determine protein domain orientation: Application to AbrB

Biochemical and Biophysical Research Communications, 431(2), 253–257.

By: A. Olson, F. Liu, A. Tucker, M. Goshe & J. Cavanagh

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Evaluation of the toxicity of 2-aminoimidazole antibiofilm agents using both cellular and model organism systems

Drug and Chemical Toxicology, 35(3), 310–315.

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

H-1, C-13, and N-15 resonance assignments and secondary structure prediction of the full-length transition state regulator AbrB from Bacillus anthracis

Biomolecular NMR Assignments, 6(1), 95–98.

By: A. Olson, B. Bobay, C. Melander & J. Cavanagh

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Identification of BfmR, a response regulator involved in biofilm development, as a target for a 2-aminoimidazole-based antibiofilm agent

Biochemistry, 51(49), 9776–9778.

By: R. Thompson, B. Bobay, S. Stowe, A. Olson, L. Peng, Z. Su, L. Actis, C. Melander, J. Cavanagh

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Structural insights into the calcium-dependent interaction between calbindin-D28K and caspase-3

FEBS Letters, 586(20), 3582–3589.

By: B. Bobay, A. Stewart, A. Tucker, R. Thompson, K. Varney & J. Cavanagh

Source: NC State University Libraries
Added: August 6, 2018

2011 review

Anti-biofilm compounds derived from marine sponges

[Review of ]. Marine Drugs, 9(10), 2010–2035.

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Flustramine inspired synthesis and biological evaluation of pyrroloindoline triazole amides as novel inhibitors of bacterial biofilms

Organic & Biomolecular Chemistry, 9(15), 5476–5481.

By: C. Bunders, J. Cavanagh & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Intercepting bacterial indole signaling with flustramine derivatives

Journal of the American Chemical Society, 133(50), 20160–20163.

By: C. Bunders, M. Minvielle, R. Worthington, M. Ortiz, J. Cavanagh & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Observing selected domains in multi-domain proteins via sortase-mediated ligation and NMR spectroscopy

Journal of Biomolecular NMR, 49(1), 3–7.

By: M. Refaei, A. Combs, D. Kojetin, J. Cavanagh, C. Caperelli, M. Rance, J. Sapitro, P. Tsang

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Binding site on human immunoglobulin G for the affinity ligand HWRGWV

Journal of Molecular Recognition, 23(3), 271–282.

By: H. Yang, P. Gurgel, D. Williams, B. Bobay, J. Cavanagh, D. Muddiman, R. Carbonell

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Long range dynamic effects of point-mutations trap a response regulator in an active conformation

FEBS Letters, 584(19), 4203–4207.

By: B. Bobay, R. Thompson, J. Hoch & J. Cavanagh

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

NMR solution structure and DNA-binding model of the DNA-binding domain of competence protein A

Journal of Molecular Biology, 398(2), 248–263.

By: C. Hobbs, B. Bobay, R. Thompson, M. Perego & J. Cavanagh

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Synergistic effects between conventional antibiotics and 2-aminoimidazole-derived antibiofilm agents

Antimicrobial Agents and Chemotherapy, 54(5), 2112–2118.

By: S. Rogers, R. Huigens, J. Cavanagh & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

Amide isosteres of oroidin: Assessment of antibiofilm activity and C. elegans Toxicity

Journal of Medicinal Chemistry, 52(15), 4582–4585.

By: J. Richards, S. Reyes, S. Stowe, A. Tucker, T. Ballard, L. Mathies, J. Cavanagh, C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

Binding site on human immunoglobulin G for the affinity ligand HWRGWV

Journal of Molecular Recognition, n/a-n/a.

By: H. Yang, P. Gurgel, D. Williams, B. Bobay, J. Cavanagh, D. Muddiman, R. Carbonell

Source: Crossref
Added: August 28, 2020

2009 journal article

Evaluation of dihydrooroidin as an antifouling additive in marine paint

International Biodeterioration & Biodegradation, 63(4), 529–532.

By: C. Melander, P. Moeller, T. Ballard, J. Richards, R. Huigens & J. Cavanagh

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

Structural and motional contributions of the Bacillus subtilis ClpC N-domain to adaptor protein interactions

Journal of Molecular Biology, 387(3), 639–652.

By: D. Kojetin, P. McLaughlin, R. Thompson, D. Dubnau, P. Prepiak, M. Rance, J. Cavanagh

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

Structural characterization of the conformational change in calbindin-d-28k upon calcium binding using differential surface modification analyzed by mass spectrometry

Biochemistry, 48(36), 8603–8614.

By: C. Hobbs, L. Deterding, L. Perera, B. Bobay, R. Thompson, T. Darden, J. Cavanagh, K. Tomer

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Co-Evolving Motions at Protein−Protein Interfaces of Two-Component Signaling Systems Identified by Covariance Analysis†

Biochemistry, 47(30), 7782–7784.

By: H. Szurmant, B. Bobay, R. White, D. Sullivan, R. Thompson, T. Hwa, J. Hoch, J. Cavanagh

Source: Crossref
Added: August 28, 2020

2008 journal article

Control of bacterial biofilms with marine alkaloid derivatives

Molecular BioSystems, 4(6), 614–621.

By: R. Huigens, L. Ma, C. Gambino, P. Moeller, A. Basso, J. Cavanagh, D. Wozniak, C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Inhibition and dispersion of proteobacterial biofilms

Chemical Communications, (14), 1698.

By: J. Richards, R. Huigens III, T. Ballard, A. Basso, J. Cavanagh & C. Melander

Sources: NC State University Libraries, Crossref
Added: August 6, 2018

2008 journal article

Insights into the nature of DNA binding of AbrB-like transcription factors

Structure (Cambridge, Mass. : 2001), 16(11), 1702–1713.

By: D. Sullivan, B. Bobay, D. Kojetin, R. Thompson, M. Rance, M. Strauch, J. Cavanagh

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Targeting RNA with cysteine-constrained peptides

Bioorganic & Medicinal Chemistry Letters, 18(2), 565–567.

By: V. Burns, B. Bobay, A. Basso, J. Cavanagh & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2007 journal article

Abh and AbrB control of Bacillus subtilis antimicrobial gene expression

Journal of Bacteriology, 189(21), 7720–7732.

By: M. Strauch, B. Bobay, J. Cavanagh, F. Yao, A. Wilson & Y. Le Breton

Source: NC State University Libraries
Added: August 6, 2018

2007 journal article

NMR assignment of the N-terminal repeat domain of Bacillus subtilis ClpC

Biomolecular NMR Assignments, 1(2), 163–165.

By: D. Kojetin, P. McLaughlin, R. Thompson, R. Venters, M. Rance & J. Cavanagh

Source: NC State University Libraries
Added: August 6, 2018

2007 journal article

Peptide binding proclivities of calcium loaded calbindin-D28k

FEBS Letters, 581(24), 4778–4782.

By: D. Kordys, B. Bobay, R. Thompson, R. Venters & J. Cavanagh

Source: NC State University Libraries
Added: August 6, 2018

2007 journal article

Predominantly buried residues in the response regulator Spo0F influence specific sensor kinase recognition

FEBS Letters, 581(7), 1425–1429.

By: P. McLaughlin, B. Bobay, E. Regel, R. Thompson, J. Hoch & J. Cavanagh

Source: NC State University Libraries
Added: August 6, 2018

2007 journal article

Tandem mass spectrometry acquisition approaches to enhance identification of protein-protein interactions using low-energy collision-induced dissociative chemical crosslinking reagents

Rapid Communications in Mass Spectrometry, 21(21), 3395–3408.

By: E. Soderblom, B. Bobay, J. Cavanagh & M. Goshe

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Measurement of multisite oxidation kinetics reveals an active site conformational change in Spo0F as a result of protein oxidation

Biochemistry, 45(20), 6260–6266.

By: J. Sharp, D. Sullivan, J. Cavanagh & K. Tomer

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

NMR structure of AbhN and comparison with AbrBN - First insights into the DNA binding promiscuity and specificity of AbrB-like transition state regulator proteins

Journal of Biological Chemistry, 281(30), 21399–21409.

By: B. Bobay, G. Mueller, R. Thompson, A. Murzin, R. Venters, M. Strauch, J. Cavanagh

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Structure, binding interface and hydrophobic transitions of Ca2+-loaded calbindin-D-28K

Nature Structural & Molecular Biology, 13(7), 641–647.

By: D. Kojetin, R. Venters, D. Kordys, R. Thompson, R. Kumar & J. Cavanagh

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Structure, binding interface and hydrophobic transitions of Ca2+-loaded calbindin-D28K

Nature Structural & Molecular Biology, 13(7), 641–647.

By: D. Kojetin, R. Venters, D. Kordys, R. Thompson, R. Kumar & J. Cavanagh

Source: Crossref
Added: August 28, 2020

2005 journal article

(4,2)D projection-reconstruction experiments for protein backbone assignment: Application to human carbonic anhydrase II and calbindin D-28K

Journal of the American Chemical Society, 127(24), 8785–8795.

By: R. Venters, B. Coggins, D. Kojetin, J. Cavanagh & P. Zhou

Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

Revised structure of the AbrB N-terminal domain unifies a diverse superfamily of putative DNA-binding proteins

FEBS Letters, 579(25), 5669–5674.

By: B. Bobay, A. Andreeva, G. Mueller, J. Cavanagh & A. Murzin

Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

Solution structure and dynamics of LuxU from Vibrio harveyi, a phosphotransferase protein involved in bacterial quorum sensing

Journal of Molecular Biology, 347(2), 297–307.

By: D. Ulrich, D. Kojetin, B. Bassler, J. Cavanagh & J. Loria

Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

Structural analysis of divalent metals binding to the Bacillus subtilis response regulator Spo0F: the possibility for In vitro metalloregulation in the initiation of sporulation

Biometals, 18(5), 449–466.

By: D. Kojetin, R. Thompson, L. Benson, S. Naylor, J. Waterman, K. Davies, C. Opperman, K. Stephenson, J. Hoch, J. Cavanagh

Source: NC State University Libraries
Added: August 6, 2018

2004 journal article

Evaluation of the DNA binding tendencies of the transition state regulator AbrB

Biochemistry, 43(51), 16106–16118.

By: B. Bobay, L. Benson, S. Naylor, B. Feeney, A. Clark, M. Goshe, M. Strauch, R. Thompson, J. Cavanagh

Source: NC State University Libraries
Added: August 6, 2018

2004 journal article

H-1, N-15, and C-13 chemical shift assignments of the Vibrio harveyi histidine phosphotransferase protein LuxU

Journal of Biomolecular NMR, 29(4), 551–552.

By: D. Ulrich, R. Thompson, B. Bassler, J. Cavanagh & J. Loria

Source: NC State University Libraries
Added: August 6, 2018

2004 journal article

Status of systems biology - does it have a future?

Drug Discovery Today: BIOSILICO, 2(5), 171–174.

By: S. Naylor & J. Cavanagh

Source: Crossref
Added: August 28, 2020

2004 article

Sub-classification of response regulators using the surface characteristics of their receiver domains (FEBS 27785) (vol 554, pg 231, 2003)

FEBS Letters, Vol. 560, pp. 227–228.

By: D. Kojetin, R. Thompson & J. Cavanagh

Source: NC State University Libraries
Added: August 6, 2018

2003 journal article

Calbindin D-28k interacts with ran-binding protein M: Identification of interacting domains by NMR spectroscopy

Biochemical and Biophysical Research Communications, 303(4), 1186–1192.

By: W. Lutz, E. Frank, T. Craig, R. Thompson, R. Venters, D. Kojetin, J. Cavanagh, R. Kumar

Source: NC State University Libraries
Added: August 6, 2018

2003 journal article

In-line desalting mass spectrometry for the study of noncovalent biological complexes

Analytical Chemistry, 75(14), 3281–3286.

By: J. Cavanagh, L. Benson, R. Thompson & S. Naylor

Source: NC State University Libraries
Added: August 6, 2018

2003 journal article

Protein-metal ion interactions, stoichiometries and relative affinities determined by on-line size exclusion gel filtration mass spectrometry

Rapid Communications in Mass Spectrometry, 17(4), 267–271.

By: L. Benson, R. Kumar, J. Cavanagh & S. Naylor

Source: NC State University Libraries
Added: August 6, 2018

2003 journal article

Sub-classification of response regulators using the surface characteristics of their receiver domains

FEBS Letters, 554(3), 231–236.

By: D. Kojetin, R. Thompson & J. Cavanagh

Source: NC State University Libraries
Added: August 6, 2018

2003 journal article

The effects of Ca2+ binding on the conformation of calbindin D- 28K: A nuclear magnetic resonance and microelectrospray mass spectrometry study

Analytical Biochemistry, 317(1), 59–66.

By: R. Venters, L. Benson, T. Craig, K. Paul, D. Kordys, R. Thompson, S. Naylor, R. Kumar, J. Cavanagh, J. Bagu

Source: NC State University Libraries
Added: August 6, 2018

2002 journal article

Alternative splicing of a beta(4) subunit proline-rich motif regulates voltage-dependent gating and toxin block of Ca(v)2.1 Ca2+ channels

Journal of Neuroscience, 22(21), 9331–9339.

By: T. Helton, D. Kojetin, J. Cavanagh & W. Horne

Source: NC State University Libraries
Added: August 6, 2018

2002 journal article

Current approaches for the study of large proteins by NMR

Journal of Molecular Structure [Including Theochem], 602(2002 Jan 9), 275–292.

By: R. Venters, R. Thompson & J. Cavanagh

Source: NC State University Libraries
Added: August 6, 2018

2002 journal article

Macromolecular assembly of the transition state regulator AbrB in its unbound and complexed states probed by microelectrospray ionization mass spectrometry

Analytical Biochemistry, 306(2), 222–227.

By: L. Benson, J. Vaughn, M. Strauch, B. Bobay, R. Thompson, S. Naylor, J. Cavanagh

Source: NC State University Libraries
Added: August 6, 2018

2002 journal article

Stoichiometries of protein - Protein/DNA binding and conformational changes for the transition-state regulator AbrB measured by pseudo cell-size exclusion chromatography-mass spectrometry

Biochemistry, 41(25), 7859–7865.

By: J. Cavanagh, R. Thompson, B. Bobay, L. Benson & S. Naylor

Source: NC State University Libraries
Added: August 6, 2018

2002 journal article

Structural and catalytic response to temperature and cosolvents of carboxylesterase EST1 from the extremely thermoacidophilic archaeon Sulfolobus solfataricus P1

Biotechnology and Bioengineering, 80(7), 784–793.

By: A. Sehgal, R. Tompson, J. Cavanagh & R. Kelly

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

Protein dynamic studies move to a new time slot

Nature Structural Biology, 8(11), 912–914.

By: J. Cavanagh & R. Venters

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

The DNA-binding domain in the Bacillus subtilis transition-state regulator AbrB employs significant motion for promiscuous DNA recognition

Journal of Molecular Biology, 305(3), 429–439.

By: J. Vaughn, V. Feher, C. Bracken & J. Cavanagh

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Novel DNA binding domain and genetic regulation model of Bacillus subtilis transition state regulator AbrB

Nature Structural Biology, 7(12), 1139–1146.

By: J. Vaughn, V. Feher, S. Naylor, M. Strauch & J. Cavanagh

Source: NC State University Libraries
Added: August 6, 2018

1995 journal article

Functional implications of the structure of the bacterial response regulator Spo0F

Journal of Cellular Biochemistry, Suppl. 21B, 25.

By: V. Feher, J. Zapf, J. Hoch, J. Whiteley, J. Cavanagh & D. W.

Source: NC State University Libraries
Added: August 6, 2018

1993 journal article

Solution structure of the Bacillus subtilis glucose permease Iia domain and its interaction with another phosphocarrier protein Hpr. J

Journal of Cellular Biochemistry, Suppl. 17C, 271.

Source: NC State University Libraries
Added: August 6, 2018