Jamie Carolyn DeWitt

Works (8)

Updated: May 25th, 2024 05:00

2024 journal article

Per- and polyfluoroalkyl substances alter innate immune function: evidence and data gaps

Journal of Immunotoxicology, 21(1).

By: D. Phelps n , A. Connors n , G. Ferrero  n, J. DeWitt n & J. Yoder n 

Contributors: D. Phelps n , A. Connors n , G. Ferrero  n, J. DeWitt n & J. Yoder n 

author keywords: Per- and polyfluoroalkyl substances; PFAS; innate immunity; ecotoxicology; zebrafish; immunotoxicology
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: May 8, 2024

2024 article

Public Health Risks of PFAS-Related Immunotoxicity Are Real

Bline, A. P., Dewitt, J. C., Kwiatkowski, C. F., Pelch, K. E., Reade, A., & Varshavsky, J. R. (2024, March 25). CURRENT ENVIRONMENTAL HEALTH REPORTS.

By: A. Bline *, J. Dewitt*, C. Kwiatkowski n, K. Pelch *, A. Reade * & J. Varshavsky *

author keywords: Immunosuppression; Vaccine; Per- and polyfluoroalkyl substances; Risk assessment; Clinical guidance; Population health
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Source: Web Of Science
Added: April 1, 2024

2023 journal article

Estimation of the Half-Lives of Recently Detected Per- and Polyfluorinated Alkyl Ethers in an Exposed Community

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 57(41), 15348–15355.

By: D. Wallis n, N. Kotlarz n , D. Knappe n , D. Collier *, C. Lea *, D. Reif n , J. McCord *, M. Strynar *, J. DeWitt*, J. Hoppin n 

author keywords: exposure; PFAS; water; humans; environment; toxicokinetic modeling
TL;DR: These fluoroethers had biological half-Lives longer than published half-lives for PFHxA and PFHpA but shorter than those for PFOA andPFOS (800-1200 days). (via Semantic Scholar)
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6. Clean Water and Sanitation (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 7, 2023

2023 journal article

Factors associated with per- and polyfluoroalkyl substances (PFAS) serum concentrations in residents of New Hanover County, North Carolina: The GenX exposure study

ENVIRONMENTAL RESEARCH, 237.

By: M. Cuffney n , A. Wilkie n, N. Kotlarz n , D. Knappe n , C. Lea  n, D. Collier  n, J. Dewitt n, J. Hoppin n 

author keywords: Per-and polyfluoroalkyl substances (PFAS); Fluoroethers; Contaminated drinking water; Environmental exposure predictors
TL;DR: It is shown that drinking water is a primary source for serum PFAS concentrations among New Hanover County residents and years of residence in the lower Cape Fear Region as a surrogate for water consumption were important for both the association and predictive investigations. (via Semantic Scholar)
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6. Clean Water and Sanitation (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 4, 2023

2023 journal article

Legacy and emerging per- and polyfluoroalkyl substances suppress the neutrophil respiratory burst

JOURNAL OF IMMUNOTOXICOLOGY, 20(1).

By: D. Phelps* , A. Palekar, H. Conley*, G. Ferrero, J. Driggers*, K. Linder*, S. Kullman n , D. Reif n  ...

author keywords: Innate immunity; neutrophils; per- and polyfluoroalkyl substances (PFAS); reactive oxygen species; zebrafish
MeSH headings : Animals; Humans; Zebrafish; Neutrophils; Reactive Oxygen Species; Respiratory Burst; Fluorocarbons / toxicity; Alkanesulfonic Acids / toxicity; Environmental Pollutants
TL;DR: This report is the first to demonstrate that these PFASs suppress neutrophil function and support the utility of employing zebrafish larvae and a human cell line as screening tools to identify chemicals that may suppress human immune function. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 15, 2023

2023 article

Quaternary Ammonium Compounds: A Chemical Class of Emerging Concern

Arnold, W. A. ., Blum, A., Branyan, J., Bruton, T. A. ., Carignan, C. C., Cortopassi, G., … Zheng, G. (2023, May 8). ENVIRONMENTAL SCIENCE & TECHNOLOGY.

By: W. Arnold *, A. Blum *, J. Branyan*, T. Bruton *, C. Carignan *, G. Cortopassi*, S. Datta *, J. DeWitt* ...

author keywords: antimicrobial resistance; policy; essential use; regrettable substitution; surfactants; disinfectants; surface coatings; COVID-19; personal care products; softeners; antistatic agents
MeSH headings : Humans; Quaternary Ammonium Compounds / chemistry; Pandemics; COVID-19; Anti-Bacterial Agents; Disinfectants
TL;DR: A critical review of the literature and scientific perspective developed by a multidisciplinary, multi-institutional team of authors provides research and policy recommendations for preserving the utility of QAC chemistries while also seeking to limit adverse environmental and human health effects. (via Semantic Scholar)
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Source: Web Of Science
Added: May 22, 2023

2020 journal article

Measurement of Novel, Drinking Water-Associated PFAS in Blood from Adults and Children in Wilmington, North Carolina

ENVIRONMENTAL HEALTH PERSPECTIVES, 128(7).

By: N. Kotlarz n , J. McCord*, D. Collier *, C. Lea *, M. Strynar *, A. Lindstrom *, A. Wilkie, J. Islam ...

MeSH headings : Adult; Alkanesulfonic Acids; Caprylates; Child; Drinking Water; Environmental Exposure / statistics & numerical data; Female; Fluorocarbons / analysis; Fluorocarbons / blood; Humans; Male; North Carolina; Nutrition Surveys; Rivers; Water Pollutants, Chemical / analysis
TL;DR: Poorly understood fluoroethers released into the Cape Fear River by a fluorochemical manufacturing facility were detected in blood samples from Wilmington, North Carolina, residents. (via Semantic Scholar)
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6. Clean Water and Sanitation (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 24, 2020

2020 journal article

Scientific Basis for Managing PFAS as a Chemical Class

ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS, 7(8), 532–543.

By: C. Kwiatkowski n, D. Andrews *, L. Birnbaum *, T. Bruton *, J. DeWitt*, D. Knappe n , M. Maffini *, M. Miller* ...

TL;DR: Options for how governments and industry can apply the class-based approach to PFAS are presented, emphasizing the importance of eliminating non-essential uses of PFAS, and further developing safer alternatives and methods to remove existing PFAS from the environment. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 14, 2020

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