Jamie Carolyn DeWitt

Works (8)

Updated: April 23rd, 2025 19:31

2024 journal article

Per- and polyfluoroalkyl substances alter innate immune function: evidence and data gaps

Journal of Immunotoxicology, 21(1).

By: D. Phelps n , A. Connors n , G. Ferrero  n, J. DeWitt n & J. Yoder n 

Contributors: D. Phelps n , A. Connors n , G. Ferrero  n, J. DeWitt n & J. Yoder n 

author keywords: Per- and polyfluoroalkyl substances; PFAS; innate immunity; ecotoxicology; zebrafish; immunotoxicology
MeSH headings : Immunity, Innate / drug effects; Humans; Animals; Fluorocarbons / adverse effects; Fluorocarbons / toxicity; Environmental Pollutants / toxicity; Environmental Pollutants / adverse effects; Environmental Exposure / adverse effects
topics (OpenAlex): Per- and polyfluoroalkyl substances research; Air Quality and Health Impacts; Effects and risks of endocrine disrupting chemicals
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: May 8, 2024

2024 article

Public Health Risks of PFAS-Related Immunotoxicity Are Real

Bline, A. P., DeWitt, J. C., Kwiatkowski, C. F., Pelch, K. E., Reade, A., & Varshavsky, J. R. (2024, March 25). Current Environmental Health Reports.

By: A. Bline *, J. DeWitt*, C. Kwiatkowski n, K. Pelch *, A. Reade* & J. Varshavsky *

author keywords: Immunosuppression; Vaccine; Per- and polyfluoroalkyl substances; Risk assessment; Clinical guidance; Population health
MeSH headings : Humans; Public Health; Risk Assessment; Fluorocarbons / toxicity; Environmental Exposure / adverse effects; Environmental Pollutants / toxicity; Immune System / drug effects; Animals
topics (OpenAlex): Per- and polyfluoroalkyl substances research; Air Quality and Health Impacts; Vitamin D Research Studies
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Source: Web Of Science
Added: April 1, 2024

2023 article

Estimation of the Half-Lives of Recently Detected Per- and Polyfluorinated Alkyl Ethers in an Exposed Community

Wallis, D. J., Kotlarz, N., Knappe, D. R. U., Collier, D. N., Lea, C. S., Reif, D., … Hoppin, J. A. (2023, October 6). Environmental Science & Technology, Vol. 57, pp. 15348–15355.

By: D. Wallis n, N. Kotlarz n , D. Knappe n , D. Collier *, C. Lea *, D. Reif n , J. McCord *, M. Strynar *, J. DeWitt*, J. Hoppin n 

author keywords: exposure; PFAS; water; humans; environment; toxicokinetic modeling
MeSH headings : Humans; Child; Adolescent; Young Adult; Adult; Middle Aged; Aged; Aged, 80 and over; Ethers; Water Pollutants, Chemical / analysis; Caprylates; Fluorocarbons / analysis; Alkanesulfonic Acids
topics (OpenAlex): Per- and polyfluoroalkyl substances research; Toxic Organic Pollutants Impact; Atmospheric chemistry and aerosols
TL;DR: These fluoroethers had biological half-Lives longer than published half-lives for PFHxA and PFHpA but shorter than those for PFOA andPFOS (800-1200 days). (via Semantic Scholar)
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6. Clean Water and Sanitation (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 7, 2023

2023 article

Factors associated with per- and polyfluoroalkyl substances (PFAS) serum concentrations in residents of New Hanover County, North Carolina: The GenX exposure study

Cuffney, M., Wilkie, A. A., Kotlarz, N., Knappe, D., Lea, C. S., Collier, D. N., … Hoppin, J. A. (2023, September 4). Environmental Research, Vol. 237.

By: M. Cuffney n , A. Wilkie n, N. Kotlarz n , D. Knappe n , C. Lea  n, D. Collier  n, J. DeWitt n, J. Hoppin n 

author keywords: Per-and polyfluoroalkyl substances (PFAS); Fluoroethers; Contaminated drinking water; Environmental exposure predictors
MeSH headings : Male; Humans; Drinking Water / chemistry; North Carolina; Water Pollutants, Chemical / analysis; Fluorocarbons; Alkanesulfonic Acids / analysis; Environmental Pollutants / analysis
topics (OpenAlex): Per- and polyfluoroalkyl substances research; Toxic Organic Pollutants Impact; Air Quality and Health Impacts
TL;DR: It is shown that drinking water is a primary source for serum PFAS concentrations among New Hanover County residents and years of residence in the lower Cape Fear Region as a surrogate for water consumption were important for both the association and predictive investigations. (via Semantic Scholar)
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6. Clean Water and Sanitation (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 4, 2023

2023 article

Legacy and emerging per- and polyfluoroalkyl substances suppress the neutrophil respiratory burst

Phelps, D. W., Palekar, A. I., Conley, H. E., Ferrero, G., Driggers, J. H., Linder, K. E., … Yoder, J. A. (2023, February 14). Journal of Immunotoxicology, Vol. 20.

By: D. Phelps* , A. Palekar, H. Conley*, G. Ferrero, J. Driggers*, K. Linder*, S. Kullman n , D. Reif n  ...

author keywords: Innate immunity; neutrophils; per- and polyfluoroalkyl substances (PFAS); reactive oxygen species; zebrafish
MeSH headings : Animals; Humans; Zebrafish; Neutrophils; Reactive Oxygen Species; Respiratory Burst; Fluorocarbons / toxicity; Alkanesulfonic Acids / toxicity; Environmental Pollutants
topics (OpenAlex): Per- and polyfluoroalkyl substances research; Toxic Organic Pollutants Impact; Atmospheric chemistry and aerosols
TL;DR: This report is the first to demonstrate that these PFASs suppress neutrophil function and support the utility of employing zebrafish larvae and a human cell line as screening tools to identify chemicals that may suppress human immune function. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 15, 2023

2023 article

Quaternary Ammonium Compounds: A Chemical Class of Emerging Concern

Arnold, W. A., Blum, A., Branyan, J., Bruton, T. A., Carignan, C. C., Cortopassi, G., … Zheng, G. (2023, May 9). Environmental Science & Technology.

By: W. Arnold *, A. Blum *, J. Branyan*, T. Bruton *, C. Carignan *, G. Cortopassi*, S. Datta *, J. DeWitt* ...

author keywords: antimicrobial resistance; policy; essential use; regrettable substitution; surfactants; disinfectants; surface coatings; COVID-19; personal care products; softeners; antistatic agents
MeSH headings : Humans; Quaternary Ammonium Compounds / chemistry; Pandemics; COVID-19; Anti-Bacterial Agents; Disinfectants
topics (OpenAlex): Environmental Chemistry and Analysis; Antimicrobial agents and applications; Water Treatment and Disinfection
TL;DR: A critical review of the literature and scientific perspective developed by a multidisciplinary, multi-institutional team of authors provides research and policy recommendations for preserving the utility of QAC chemistries while also seeking to limit adverse environmental and human health effects. (via Semantic Scholar)
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Source: Web Of Science
Added: May 22, 2023

2020 article

Measurement of Novel, Drinking Water-Associated PFAS in Blood from Adults and Children in Wilmington, North Carolina

Kotlarz, N., McCord, J., Collier, D., Lea, C. S., Strynar, M., Lindstrom, A. B., … Hoppin, J. A. (2020, July 1). Environmental Health Perspectives, Vol. 128.

By: N. Kotlarz n , J. McCord*, D. Collier *, C. Lea *, M. Strynar*, A. Lindstrom *, A. Wilkie  n, J. Islam  n ...

MeSH headings : Adult; Alkanesulfonic Acids; Caprylates; Child; Drinking Water; Environmental Exposure / statistics & numerical data; Female; Fluorocarbons / analysis; Fluorocarbons / blood; Humans; Male; North Carolina; Nutrition Surveys; Rivers; Water Pollutants, Chemical / analysis
topics (OpenAlex): Per- and polyfluoroalkyl substances research; Toxic Organic Pollutants Impact; Quantum Electrodynamics and Casimir Effect
TL;DR: Poorly understood fluoroethers released into the Cape Fear River by a fluorochemical manufacturing facility were detected in blood samples from Wilmington, North Carolina, residents. (via Semantic Scholar)
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6. Clean Water and Sanitation (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 24, 2020

2020 article

Scientific Basis for Managing PFAS as a Chemical Class

Kwiatkowski, C. F., Andrews, D. Q., Birnbaum, L. S., Bruton, T. A., DeWitt, J. C., Knappe, D. R. U., … Blum, A. (2020, June 30). Environmental Science & Technology Letters, Vol. 7, pp. 532–543.

By: C. Kwiatkowski n, D. Andrews *, L. Birnbaum *, T. Bruton *, J. DeWitt*, D. Knappe n , M. Maffini *, M. Miller* ...

topics (OpenAlex): Per- and polyfluoroalkyl substances research; Toxic Organic Pollutants Impact; Atmospheric chemistry and aerosols
TL;DR: Options for how governments and industry can apply the class-based approach to PFAS are presented, emphasizing the importance of eliminating non-essential uses of PFAS, and further developing safer alternatives and methods to remove existing PFAS from the environment. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 14, 2020

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