Works (87)
Updated: August 8th, 2024 04:52
2022 article
Comparison of the mechanical properties and anchoring performance of polyvinylidene fluoride and polypropylene barbed sutures for tendon repair
Huang, Y., Cadet, E. R., King, M. W., & Cole, J. H. (2022, June 8). JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, Vol. 6.
author keywords: barbed sutures; biomechanics; ex vivo; polypropylene; polyvinylidene fluoride; tendon repair
MeSH headings : Animals; Biomechanical Phenomena; Fluorocarbon Polymers; Polypropylenes; Polyvinyls; Suture Techniques; Sutures; Swine; Tendon Injuries / surgery; Tendons; Tensile Strength
TL;DR:
PVDF barbed sutures provided better mechanical properties and improved tissue anchoring performance compared to the barbed PP suture for porcine patellar tendon repair, demonstrating that PVDF monofilament sutURES can be barbed and used effectively for tendon repair.
(via Semantic Scholar)
open access via onlinelibrary.wiley.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 9, 2022
2021 article
Changes in Cellular Crosstalk between Skeletal Muscle Myoblasts and Bone Osteoblasts with Aging
Doering, J. A., Britt, C. E., Sawicki, G. S., & Cole, J. H. (2021, April 27).
TL;DR:
The results suggest co-culture may have a controlling effect, with the two cell types acting together to promote differentiation more than in mono-cultures, yet this response was not altered by age.
(via Semantic Scholar)
Source: ORCID
Added: April 4, 2022
2021 article
Heterogeneous Tissue Modulus Improved Prediction of Mechanical Behavior in Osteoporotic Vertebral Cancellous Bone
Cox, J. M., Smith, J. D., Meulen, M. C. H., & Cole, J. H. (2021, December 1).
TL;DR:
The influence of tissue modulus on normal and osteoporotic cancellous bone structural integrity is isolated, indicated by the apparent elastic modulus under uniaxial compression and patterns of internal tissue strain, and it is concluded that future work exploring trabecular bone mechanics through finite element analysis should incorporate specimen-specific average tissueModulus at a minimum, but heterogeneous tissue moduli is recommended to maximize the functional similarity of bone in silico with bone in vivo.
(via Semantic Scholar)
Source: ORCID
Added: April 4, 2022
2021 article
Location of brachial plexus birth injury affects functional outcomes in a rat model
Doshi, R. M., Reid, M. Y., Dixit, N. N., Fawcett, E. B., Cole, J. H., & Saul, K. R. (2021, September 5). JOURNAL OF ORTHOPAEDIC RESEARCH, Vol. 9.
author keywords: brachial plexus; forelimb; gait; musculoskeletal model; rat model
MeSH headings : Animals; Birth Injuries / complications; Brachial Plexus / injuries; Brachial Plexus Neuropathies / complications; Range of Motion, Articular / physiology; Rats; Rotator Cuff; Shoulder Joint
TL;DR:
The results suggest the presence of compensatory motor control strategies during locomotion following BPBI and support emphasis on functional movement analysis in treatment of BPBI.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: September 13, 2021
2020 journal article
A minimally invasive technique for serial intraosseous perfusion measurements in the murine tibia using laser Doppler flowmetry
METHODSX, 7, 100814.
TL;DR:
A modified, minimally invasive LDF procedure to measure intraosseous perfusion in the murine tibia without stimulating local or systemic inflammation or inducing gait abnormalities is developed and can be used to measure perfusion weekly for up to at least a month.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 8, 2021
2020 journal article
Assessing changes in attitudes toward engineering and biomechanics resulting from a high school outreach event
Journal of Biomechanics, 103, 109683.
author keywords: Outreach; High school; Engagement; Quantitative; Engineering; National Biomechanics Day
MeSH headings : Attitude; Biomechanical Phenomena; Engineering; Humans; Schools; Surveys and Questionnaires
TL;DR:
This quantitative study examines participants' attitude changes following one such event and finds significant gains in all three areas, which could lead to more students recruited to study a variety of engineering disciplines, ultimately addressing the ongoing national shortage of qualified engineers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
Sources: ORCID, Crossref, NC State University Libraries
Added: August 27, 2020
2020 article
Biomechanics of Bone
OSTEOPOROSIS: PATHOPHYSIOLOGY AND CLINICAL MANAGEMENT, 3RD EDITION, pp. 185–209.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: August 23, 2021
2020 article
Characterizing Trabecular Bone Properties near the Glenohumeral Joint Following Brachial Plexus Birth Injury
Fawcett, E. B., McCormick, C. M., Murray, A. F., Crouch, D. L., Saul, K. R., & Cole, J. H. (2020, February 27).
TL;DR:
Data suggest deformities are worse near the articulating surface, likely due to the greater amount of mechanical loading, and the reduction in trabecular microstructure and mineralization may compromise bone strength of the affected limb following BPBI.
(via Semantic Scholar)
Source: ORCID
Added: April 4, 2022
2020 article
Forelimb unloading impairs glenohumeral muscle development in growing rats
Tushak, S. K., Tamburro, M. K., Fawcett, E. B., LE, L. E. M., Saul, K. R., & Cole, J. H. (2020, February 27).
TL;DR:
This study demonstrated that forearm amputation had greater effects on muscle than forelimb suspension, which was administered a few weeks later than amputation, and both methods of altered loading significantly affected muscle mass, sarcomere length, and optimal muscle length compared to control rats.
(via Semantic Scholar)
Source: ORCID
Added: April 4, 2022
2020 journal article
Influence of Brachial Plexus Birth Injury Location on Glenohumeral Joint Morphology
JOURNAL OF HAND SURGERY-AMERICAN VOLUME, 46(6).
author keywords: Brachial plexus birth injury; glenoid inclination; glenoid version; humeral head morphology; radius of curvature
MeSH headings : Animals; Birth Injuries / diagnostic imaging; Brachial Plexus / diagnostic imaging; Brachial Plexus / injuries; Brachial Plexus Neuropathies / diagnostic imaging; Brachial Plexus Neuropathies / etiology; Humans; Rats; Rats, Sprague-Dawley; Shoulder Joint / diagnostic imaging; X-Ray Microtomography
TL;DR:
It is suggested that glenoid deformities occur after postganglionics BPBI but not after preganglionic BPBI, whereas the humeral head is smaller after pre ganglionic injury, possibly suggesting an overall decreased biological growth rate in this group.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 21, 2021
2020 journal article
Integrated iterative musculoskeletal modeling predicts bone morphology following brachial plexus birth injury (BPBI)
Journal of Biomechanics, 103, 109658.
author keywords: Brachial plexus birth injury; Preganglionic; Postganglionic; Finite element; Computational model; Bone growth; Musculoskeletal
MeSH headings : Birth Injuries; Brachial Plexus / injuries; Brachial Plexus Neuropathies; Child; Humans; Scapula; Shoulder Joint
TL;DR:
Differences in muscle mass and length between the pre ganglionic and postganglionic injuries are critical mechanical drivers of the altered glenohumeral joint shape.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: ORCID
Added: April 4, 2022
2020 journal article
Preganglionic and Postganglionic Brachial Plexus Birth Injury Effects on Shoulder Muscle Growth
JOURNAL OF HAND SURGERY-AMERICAN VOLUME, 46(2).
author keywords: Brachial plexus birth injury; contractures; muscle mass; range of motion; sarcomere length
MeSH headings : Animals; Birth Injuries / complications; Brachial Plexus / injuries; Brachial Plexus Neuropathies; Muscle, Skeletal; Range of Motion, Articular; Rats; Rats, Sprague-Dawley; Shoulder; Shoulder Joint
TL;DR:
The findings suggest that the presence of contracture does not derive from restricted longitudinal muscle growth alone, but also depends on the extent of muscle mass loss occurring simultaneously after the injury.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 12, 2021
2019 article
A Minimally Invasive Technique for Serial Intraosseous Perfusion Measurements in the Murine Tibia Using Laser Doppler Flowmetry
Hanne, N. J., Easter, E. D., Stangeland-Molo, S., & Cole, J. H. (2019, July 22). (Vol. 7). Vol. 7.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: April 4, 2022
2019 article
High Fat Diet-Induced Obesity Negatively Affects Whole Bone Bending Strength but not Cortical Structure in the Femur
Hanne, N. J., Steward, A. J., Cox, J. M., Easter, E. D., Thornburg, H. L., Sessions, M. R., … Cole, J. H. (2019, August 8). (Vol. 8). Vol. 8.
TL;DR:
It is revealed that high fat diet negatively affected cancellous microstructure without affecting osteovascular structure, and whole-bone strength without altering cortical geometry or material properties, indicating that HFD negatively affects cancellous bone without affecting bone strength.
(via Semantic Scholar)
Source: ORCID
Added: April 4, 2022
2019 article
Influence of wire configuration on resistance to fragment distraction of tension bands placed in a greater trochanteric osteotomy model
VETERINARY SURGERY, Vol. 49, pp. 710–718.
MeSH headings : Animals; Bone Wires / veterinary; Dogs; Femur / surgery; Fracture Fixation / veterinary; Osteotomy / methods; Osteotomy / veterinary
TL;DR:
Wire configurations reaching greater initial tension, such as the DL, allowed constructs to resist higher tensile loads and may be warranted when tension bands are expected to sustain high Tensile loads.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: November 25, 2019
2019 article
Ischemic Stroke Reduces Bone Perfusion and Alters Osteovascular Structure
Hanne, N. J., Steward, A. J., Geeroms, C., Easter, E. D., Thornburg, H. L., Kerckhofs, G., … Cole, J. H. (2019, August 8). (Vol. 8). Vol. 8.
TL;DR:
The exercise-induced reduction in the amount of Type H vessels and the stroke-exercise effect on osteovascular structure suggest moderate aerobic activity may have detrimental effects on bone remodeling during early stroke recovery.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: April 4, 2022
2019 journal article
Mass spectrometry imaging (MSI) of fresh bones using infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI)
ANALYTICAL METHODS, 11(46), 5929–5938.
MeSH headings : Animals; Diagnostic Imaging; Lasers; Mice; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
TL;DR:
An effective strategy for direct analysis and two-dimensional matrix-assisted laser desorption electrospray ionization (IR-MALDESI) mass spectrometry imaging (MSI) of mouse bones that underwent no chemical treatments prior to analysis is reported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 16, 2019
2019 journal article
Minimally invasive laser Doppler flowmetry is suitable for serial bone perfusion measurements in mice
Bone Reports, 11, 100231.
author keywords: Laser Doppler flowmetry; Bone blood perfusion; Vascular supply; Minimally invasive; Serial measurement; In vivo
TL;DR:
It is determined that the minimally invasive in vivo laser Doppler flowmetry technique is suitable for serial in vivo measurements of intraosseous blood perfusion without inducing localized inflammation or negatively affecting gait patterns in mice.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: ORCID
Added: April 4, 2022
2019 journal article
Stroke Prevents Exercise-Induced Gains in Bone Microstructure But Not Composition in Mice
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 141(12).
author keywords: stroke; bone; exercise; microstructure; composition; gait; adaptation
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 27, 2020
2019 article
Stroke prevents exercise-induced gains in bone microstructure but not composition in mice
Hanne, N. J., Steward, A. J., Sessions, M. R., Thornburg, H. L., Sheng, H., & Cole, J. H. (2019, July 19). (Vol. 7). Vol. 7.
TL;DR:
It is shown that stroke inhibits exercise-induced changes to femoral microstructure but not tibial composition, even without changes to gait, and affected-unaffected limb differences in cortical bone structure and bone formation rate in ambulatory mice show that stroke affects bone health even without bedrest.
(via Semantic Scholar)
Source: ORCID
Added: April 4, 2022
2019 article
Validating Minimally Invasive Laser Doppler Flowmetry for Serial Bone Perfusion Measurements in Mice
Hanne, N. J., Easter, E. D., & Cole, J. H. (2019, July 19). (Vol. 7). Vol. 7.
TL;DR:
Modified, minimally invasive laser Doppler flowmetry (LDF) technique was validated for serial measures of tibial perfusion in mice and demonstrated that it can be used serially in the same mouse without causing inflammation or gait perturbations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: April 4, 2022
2018 journal article
Characterization of Tensioned PDMS Membranes for Imaging Cytometry on Microraft Arrays
ANALYTICAL CHEMISTRY, 90(7), 4792–4800.
MeSH headings : Automation; Cell Line, Tumor; Dimethylpolysiloxanes / chemistry; Flow Cytometry; Humans; Lung Neoplasms / diagnostic imaging; Microarray Analysis; Optical Imaging; Surface Properties
TL;DR:
The development of microfabrication strategies and physically motivated mathematical modeling of membrane deformation of PDMS microarrays are reported and this approach is readily applicable to control the deforming of similar membranes in MEMs devices, sensors, and microfluidics.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2018 article
Evaluating Wire Configurations for Tension Band Constructs using a Canine Greater Trochanteric Osteotomy Model
Thompson, E., Robe, A. K., Roe, S. C., & Cole, J. H. (2018, May 21). (Vol. 5). Vol. 5.
Source: ORCID
Added: April 4, 2022
2018 article
In Vitro Fatigue Evaluation of Chimney Endovascular Aneurysm Repair: A Case Study
Zhang, R., Crawford, S., Forbes, T., Cole, J. H., & King, M. W. (2018, September). JOURNAL OF VASCULAR SURGERY, Vol. 68, pp. E92–E92.
TL;DR:
Overall, anatomic success was similar between the two procedures, however, there were notable differences in duplex ultrasound findings postoperatively, and this decline in vein diameter is mild and slower than anticipated.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: October 19, 2018
2018 thesis
Studies of Barbed Surgical Sutures Associated with Materials, Anchoring Performance and Histology.
Source: ORCID
Added: April 4, 2022
2017 conference paper
Diet-induced obesity deteriorates cancellous bone structure despite increased blood perfusion
Orthopaedic Research Society Annual Meeting, San Diego, CA, March 19-22. Presented at the http://www.ors.org/Transactions/63/1699.pdf.
Event: http://www.ors.org/Transactions/63/1699.pdf
Source: ORCID
Added: April 4, 2022
2017 conference paper
Smart Heparin Transcutaneous Patch
Society for Biomaterials Annual Meeting.
Source: ORCID
Added: April 4, 2022
2017 journal article
Thrombin-responsive transcutaneous patch for auto-anticoagulant regulation
Advanced Materials, 29(4).
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2016 conference paper
Bone blood perfusion increases with diet-induced obesity, associated with trabecular deterioration in mice
Biomedical Engineering Society Annual Meeting, Minneapolis, MN, October 5-8.
Source: ORCID
Added: April 4, 2022
2016 conference paper
Comparison of multiple tension band wire configurations on a greater trochanteric osteotomy model
American College of Veterinary Surgeons Surgery Summit, Seattle, WA, October 6-8.
Source: ORCID
Added: April 4, 2022
2016 journal article
Enhanced cellular infiltration of human adipose-derived stem cells in allograft menisci using a needle-punch method
Journal of Orthopaedic Surgery and Research, 11(1), 132.
Source: ORCID
Added: April 4, 2022
2016 journal article
Mechanical and Vascular Cues Synergistically Enhance Osteogenesis in Human Mesenchymal Stem Cells
TISSUE ENGINEERING PART A, 22(15-16), 997–1005.
Contributors: A. Steward n, n , F. Ligler n & E. Loboa n
MeSH headings : Adolescent; Adult; Antigens, Differentiation / biosynthesis; Coculture Techniques; Endothelial Cells / cytology; Endothelial Cells / metabolism; Female; Humans; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / metabolism; Neovascularization, Physiologic; Osteogenesis
TL;DR:
The concurrent application of strain to an MSC-EC co- culture resulted in a significant increase in calcium accretion and mineral deposition, suggesting that co-culture and strain synergistically enhance osteogenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science
Added: August 6, 2018
2016 conference paper
The angiogenic and osteogenic effects of cyclic tensile strain on a co-culture of human MSCs and HUVECs
Orthopaedic Research Society Annual Meeting, Orlando, FL, March 5-8. Presented at the http://www.ors.org/Transactions/62/0197.pdf.
Event: http://www.ors.org/Transactions/62/0197.pdf
Source: ORCID
Added: April 4, 2022
2016 journal article
Thrombin-Responsive Transcutaneous Patch for Auto-Anticoagulant Regulation
Advanced Materials, 29(4), 1604043.
Contributors: Y. Zhang n, J. Yu n, J. Wang n, N. Hanne n, Z. Cui n, C. Qian n, C. Wang n, H. Xin n
MeSH headings : Anticoagulants; Blood Coagulation; Heparin; Skin; Thrombin / administration & dosage
TL;DR:
A thrombin-responsive closed-loop patch is developed for prolonged heparin delivery in a feedback-controlled manner that can sustainably regulate blood coagulation in response toThrombin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries, ORCID
Added: January 19, 2020
2014 journal article
Reduced Tissue-Level Stiffness and Mineralization in Osteoporotic Cancellous Bone
Calcified Tissue International, 95(2), 125–131.
Contributors: G. Kim *, * , A. Boskey *, S. Baker * & M. Meulen *
author keywords: Nanoindentation; Raman spectroscopy; Osteoporosis; Human trabecular bone
MeSH headings : Absorptiometry, Photon; Aged; Aged, 80 and over; Cadaver; Calcification, Physiologic / physiology; Female; Humans; Lumbar Vertebrae / diagnostic imaging; Lumbar Vertebrae / physiopathology; Middle Aged; Osteoporosis / diagnostic imaging; Osteoporosis / physiopathology
TL;DR:
Differences in tissue composition and mechanical properties with osteoporosis that could contribute to increased fragility in addition to changes in trabecular architecture and bone volume are found.
(via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: December 11, 2020
2014 journal article
Reduced tissue-level stiffness and mineralization in osteoporotic cancellous bone
Calcified Tissue International, 95(2), 125–131.
Source: ORCID
Added: April 4, 2022
2013 journal article
Oxygen-Dependent Mineralization Differences with High Intrinsic Aerobic Capacity are Associated with Osteoblast Extracellular Matrix Gene Expression
Journal of Bone and Mineral Research, 28(Suppl 1), SA0218. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000332035803130&KeyUID=WOS:000332035803130
Source: ORCID
Added: April 4, 2022
2012 conference paper
Hypoxia disrupts osteoblast proliferation and mineralization in rats with high intrinsic aerobic capacity
JOURNAL OF BONE AND MINERAL RESEARCH, 27(Suppl 1), MO0230.
Event: WILEY-BLACKWELL
Source: ORCID
Added: April 4, 2022
2012 journal article
Raman Spectroscopic Analysis of Human Tissue Engineered Oral Mucosa Constructs (EVPOME) Perturbed by Physical and Biochemical Methods
Biomedical Vibrational Spectroscopy V: Advances in Research and Industry, 8219.
Contributors: A. Khmaladze *, A. Ganguly *, M. Raghavan*, S. Kuo*, * , C. Marcelo*, S. Feinberg *, K. Izumi *
author keywords: Raman Spectroscopy; EVPOME; AlloDerm (R); Tissue Engineering; Regenerative Medicine
TL;DR:
Near-infrared Raman Spectroscopy is applied to in-vitro monitoring of the viability of tissue constructs (EVPOMEs) and correlation of the peak height ratios of CH2 deformation to phenylalanine ring breathing is shown, providing a Raman metric to distinguish between viable and nonviable constructs.
(via Semantic Scholar)
Source: ORCID
Added: April 4, 2022
2012 conference paper
Raman spectroscopic analysis of human tissue engineered oral mucosa constructs (EVPOME) perturbed by physical and biochemical methods
Biomedical Vibrational Spectroscopy V: Advances in Research and Industry, 8219, 82190J.
Event: International Society for Optics and Photonics
Source: ORCID
Added: April 4, 2022
2012 conference paper
Rats with high intrinsic aerobic capacity retain increased femoral cortical thickness with aging
Orthopaedic Research Society Annual Meeting, San Francisco, CA. Presented at the http://www.ors.org/Transactions/58/0379.pdf.
Event: http://www.ors.org/Transactions/58/0379.pdf
Source: ORCID
Added: April 4, 2022
2012 journal article
Tissue-Engineered Constructs of Human Oral Mucosa Examined by Raman Spectroscopy
Tissue Engineering Part C-Methods, 19(4), 299–306.
Contributors: A. Khmaladze *, A. Ganguly *, S. Kuo*, M. Raghavan*, R. Kainkaryam, * , K. Izumi *, C. Marcelo*, S. Feinberg *, M. Morris*
MeSH headings : Calcium / metabolism; Glucose / metabolism; Humans; Mouth Mucosa; Sirolimus / pharmacology; Spectrum Analysis, Raman / methods; Tissue Engineering
TL;DR:
The application of near-infrared Raman spectroscopy to in vitro monitoring of EVPOMEs during their manufacturing process is demonstrated, with the ultimate goal of applying this technology in situ to monitor the grafted EVPomes.
(via Semantic Scholar)
Source: ORCID
Added: April 4, 2022
2012 journal article
Tissue-engineered constructs of human oral mucosa examined by Raman spectroscopy
Tissue Engineering Part C: Methods, 19(4), 299–306.
Source: ORCID
Added: April 4, 2022
2011 conference paper
Intrinsic aerobic capacity influences osteoblast proliferation, differentiation, and mineralization in vitro
Orthopaedic Research Society Annual Meeting, Long Beach, CA. Presented at the http://www.ors.org/Transactions/57/2301.pdf.
Event: http://www.ors.org/Transactions/57/2301.pdf
Source: ORCID
Added: April 4, 2022
2011 journal article
Whole Bone Mechanics and Bone Quality
Clinical Orthopaedics and Related Research®, 469(8), 2139–2149.
Contributors: * & M. Meulen *
MeSH headings : Bone and Bones / physiology; Computational Biology; Elastic Tissue / physiology; Fractures, Bone / physiopathology; Humans; Stress, Mechanical; Weight-Bearing / physiology
TL;DR:
Understanding and preventing skeletal fractures is clinically important and Laboratory tests of whole bone strength are currently the only measures for in vivo fracture prediction, but combined imaging and engineering models may be able to predict whole bonestrength noninvasively.
(via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: January 5, 2021
2011 journal article
Whole bone mechanics and bone quality
Clinical Orthopaedics and Related Research®, 469(8), 2139–2149.
Source: ORCID
Added: April 4, 2022
2010 chapter
Biomechanics of bone
In Osteoporosis (pp. 157–179). Humana Press.
Source: ORCID
Added: April 4, 2022
2010 conference paper
Differences in oxygen consumption rate of osteoblast lineage cells in rats bred for high and low aerobic capacity
JOURNAL OF BONE AND MINERAL RESEARCH, 25(Suppl 1), SA0241.
Event: WILEY-BLACKWELL
Source: ORCID
Added: April 4, 2022
2010 journal article
Influence of Intrinsic Aerobic Exercise Capacity on Skeletal Health
Medicine and Science in Sports and Exercise, 42(5), 821. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000290226302793&KeyUID=WOS:000290226302793
Contributors: G. Goulet, N. Halonen, J. Cole, L. Koch, S. Britton, M. Morris, R. Zernicke, K. Kozloff
Source: ORCID
Added: April 4, 2022
2010 conference paper
Influence of intrinsic and trained aerobic capacity on bone mineralization and material properties
Orthopaedic Research Society Annual Meeting, New Orleans, LA. Presented at the http://www.ors.org/Transactions/56/0069.pdf.
Event: http://www.ors.org/Transactions/56/0069.pdf
Source: ORCID
Added: April 4, 2022
2010 conference paper
Intrinsic aerobic capacity influences MSC proliferation, mineralization, and fracture healing
Orthopaedic Research Society Annual Meeting, New Orleans, LA. Presented at the http://www.ors.org/Transactions/56/1712.pdf.
Event: http://www.ors.org/Transactions/56/1712.pdf
Source: ORCID
Added: April 4, 2022
2010 conference paper
Pre-clinical feasibility study of a novel implant for treatment of a cartilage defect in the medial femoral condyle
Orthopaedic Research Society Annual Meeting, New Orleans, LA. Presented at the http://www.ors.org/Transactions/56/1011.pdf.
Event: http://www.ors.org/Transactions/56/1011.pdf
Source: ORCID
Added: April 4, 2022
2009 journal article
Biomechanics of Bone
Osteoporosis: Pathophysiology and Clinical Management, Second Edition, 157–179.
Contributors: * , M. Meulen * & R. Adler
TL;DR:
Characterizing bone material properties, whether at the tissue level or at the chemical composition level of the mineral and matrix constituents, may improve the ability to predict structural competence and fracture risk reliably.
(via Semantic Scholar)
Source: ORCID
Added: April 4, 2022
2009 journal article
Correcting Fan-Beam Magnification in Clinical Densitometry Scans of Growing Subjects
Journal of Clinical Densitometry, 12(3), 322–329.
Contributors: * , J. Dowthwaite *, T. Scerpella * & M. Meulen *
MeSH headings : Absorptiometry, Photon / methods; Adolescent; Age Factors; Algorithms; Bone Density; Bone Development / physiology; Child; Child, Preschool; Cohort Studies; Diagnostic Errors / prevention & control; Female; Gymnastics; Humans; Image Processing, Computer-Assisted; Radiographic Magnification / methods; Waist Circumference
TL;DR:
To isolate bone accrual from magnification error in growing subjects, a correction method based on waist girth was developed, which was applied to dual-energy X-ray absorptiometry output obtained in a cohort of premenarcheal gymnasts and nongymnasts and may enhance detection of skeletal adaptation, particularly in pediatric populations.
(via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: January 5, 2021
2009 journal article
Correcting fan-beam magnification in clinical densitometry scans of growing subjects
Journal of Clinical Densitometry, 12(3), 322–329.
Source: ORCID
Added: April 4, 2022
2009 conference paper
Differential effects of intrinsic aerobic capacity and exercise training on bone composition and structure
JOURNAL OF BONE AND MINERAL RESEARCH, 24(Suppl 1), SA0024.
Event: WILEY-BLACKWELL
Source: ORCID
Added: April 4, 2022
2009 conference paper
Relating material properties and composition in osteoporotic bone tissue
Orthopaedic Research Society Annual Meeting, Las Vegas, NV. Presented at the http://www.ors.org/Transactions/55/0654.pdf.
Event: http://www.ors.org/Transactions/55/0654.pdf
Source: ORCID
Added: April 4, 2022
2009 journal article
Transcutaneous Raman Spectroscopy of Murine Bone In Vivo
Applied Spectroscopy, 63(3), 286–295. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000264142600004&KeyUID=WOS:000264142600004
Source: ORCID
Added: April 4, 2022
2009 conference paper
Variation in bone tissue structure and composition with rats selectively bred for high and low aerobic running capacity
39th Annual IBMS Sun Valley Workshop on Musculoskeletal Biology, Sun Valley, ID.
Source: ORCID
Added: April 4, 2022
2008 journal article
Image-guided Raman spectroscopic recovery of canine cortical bone contrast in situ
Optics Express, 16(16), 12190–12200.
Contributors: S. Srinivasan*, M. Schulmerich*, * , K. Dooley *, J. Kreider*, B. Pogue *, M. Morris*, S. Goldstein *
MeSH headings : Animals; Dogs; Image Enhancement / methods; Image Interpretation, Computer-Assisted / methods; Phantoms, Imaging; Radiography; Spectrum Analysis, Raman / methods; Tibia / chemistry; Tibia / diagnostic imaging
TL;DR:
This study presents the first known IG-RS results from tissue and indicates that intrinsically high contrasts (on the order of a hundred fold) are available and this technique provides additional information to standard imaging methods.
(via Semantic Scholar)
Source: ORCID
Added: April 4, 2022
2008 conference paper
Microdamage assessment in rat cortical bone by light scattering
Orthopaedic Research Society Annual Meeting, San Francisco, CA. Presented at the http://www.ors.org/Transactions/54/0138.pdf.
Event: http://www.ors.org/Transactions/54/0138.pdf
Source: ORCID
Added: April 4, 2022
2008 journal article
Non-invasive Detection of Bone Microdamage by Light Scattering.
Journal of Bone and Mineral Research, 23, S492. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000259411002596&KeyUID=WOS:000259411002596
Source: ORCID
Added: April 4, 2022
2008 conference paper
Non-invasive Detection of Bone Microdamage by Light Scattering.
JOURNAL OF BONE AND MINERAL RESEARCH, 23, S492–S492.
Event: AMER SOC BONE & MINERAL RES 2025 M ST, NW, STE 800, WASHINGTON, DC 20036-3309 USA
Source: ORCID
Added: April 4, 2022
2008 journal article
Non-invasive In Vivo Raman Spectroscopy in Mice.
Journal of Bone and Mineral Research, 23, S366. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000259411002114&KeyUID=WOS:000259411002114
Source: ORCID
Added: April 4, 2022
2008 conference paper
Non-invasive In Vivo Raman Spectroscopy in Mice.
JOURNAL OF BONE AND MINERAL RESEARCH, 23, S366–S366.
Event: AMER SOC BONE & MINERAL RES 2025 M ST, NW, STE 800, WASHINGTON, DC 20036-3309 USA
Source: ORCID
Added: April 4, 2022
2008 conference paper
Non-invasive detection of bone microdamage by light scattering
JOURNAL OF BONE AND MINERAL RESEARCH, 23(Suppl 1), S492.
Event: WILEY-BLACKWELL
Source: ORCID
Added: April 4, 2022
2008 journal article
Noninvasive Raman tomographic imaging of canine bone tissue
Journal of Biomedical Optics, 13(2), 020506.
Contributors: M. Schulmerich*, * , K. Dooley *, M. Morris*, J. Kreider*, S. Goldstein *, S. Srinivasan*, B. Pogue *
author keywords: tomography; Raman spectroscopy; bone; diffuse; imaging; non-invasive
MeSH headings : Animals; Dogs; Image Enhancement / methods; Image Interpretation, Computer-Assisted / methods; Models, Animal; Spectrum Analysis, Raman / methods; Tibia / anatomy & histology; Tomography, Optical / methods
TL;DR:
This technique has been applied to image the composition of bone tissue within an intact section of a canine limb using 785-nm laser excitation to prevent thermal damage to the tissue.
(via Semantic Scholar)
Source: ORCID
Added: April 4, 2022
2008 journal article
Optical clearing in transcutaneous Raman spectroscopy of murine cortical bone tissue
Journal of Biomedical Optics, 13(2), 021108.
Contributors: M. Schulmerich*, * , K. Dooley *, M. Morris*, J. Kreider* & S. Goldstein *
author keywords: transcutaneous; optical clearing; Raman spectroscopy; bone; fiber optic probe
MeSH headings : Animals; Glycerol / administration & dosage; In Vitro Techniques; Mice; Refractometry; Spectrum Analysis, Raman / methods; Tibia / drug effects; Tibia / physiology
TL;DR:
The effect of optical clearing with glycerol on the Raman spectra of bone tissue acquired transcutaneously on right and left tibiae from four mice is studied to improve the cross-correlation between the recovered bone factor and the exposed bone measurement in a low signal-to-noise region of the bone spectra.
(via Semantic Scholar)
Source: ORCID
Added: April 4, 2022
2008 conference paper
Raman tomography of tissue phantoms and bone tissue
Biomedical Optical Spectroscopy, 6853, 68530V.
Event: International Society for Optics and Photonics
Source: ORCID
Added: April 4, 2022
2008 chapter
Raman tomography of tissue phantoms and bone tissue - art. no. 68530V
In Biomedical Optical Spectroscopy (Vol. 6853, p. V8530).
Contributors: M. Schulmerich*, S. Srinivasan*, J. Kreider*, * , K. Dooley *, S. Goldstein *, B. Pogue *, M. Morris*
TL;DR:
Tomographic reconstruction of objects located several millimeters below the surface of highly scattering media is reported and a reconstruction of the tibial diaphysis of an intact canine hind limb using spatial priors generated from micro-computed tomography is demonstrated.
(via Semantic Scholar)
Source: ORCID
Added: April 4, 2022
2007 conference paper
Characterization of bone and soft tissue composition by Raman spectroscopy
Cells Tissues Organs, 189, 300.
Event: Karger
Source: ORCID
Added: April 4, 2022
2007 journal article
Finite element models more accurately predict structural behavior of human cancellous bone when using specimen-specific tissue properties
Journal of Bone and Mineral Research, 22, S225. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000250509101201&KeyUID=WOS:000250509101201
Source: ORCID
Added: April 4, 2022
2007 conference paper
Finite element models more accurately predict structural behavior of human cancellous bone when using specimen-specific tissue properties
JOURNAL OF BONE AND MINERAL RESEARCH, 22, S225–S225.
Event: AMER SOC BONE & MINERAL RES 2025 M ST, NW, STE 800, WASHINGTON, DC 20036-3309 USA
Source: ORCID
Added: April 4, 2022
2007 journal article
Measurement protocols for the non-invasive assessment of bone constituent properties by Raman Spectroscopy
Journal of Bone and Mineral Research, 22, S257. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000250509101329&KeyUID=WOS:000250509101329
Source: ORCID
Added: April 4, 2022
2007 conference paper
Measurement protocols for the non-invasive assessment of bone constituent properties by Raman Spectroscopy
Journal of Bone and Mineral Research, 22, S257–S257.
Event: AMER SOC BONE & MINERAL RES 2025 M ST, NW, STE 800, WASHINGTON, DC 20036-3309 USA
Source: ORCID
Added: April 4, 2022
2007 journal article
The role of architecture and tissue properties in the structural integrity of human vertebral cancellous bone
Source: ORCID
Added: April 4, 2022
2006 journal article
MicroCT and DXA mineral measures fail to predict material properties in the human lumbar spine.
Journal of Bone and Mineral Research, 21, S352. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000240866303036&KeyUID=WOS:000240866303036
Source: ORCID
Added: April 4, 2022
2006 conference paper
MicroCT and DXA mineral measures fail to predict material properties in the human lumbar spine.
JOURNAL OF BONE AND MINERAL RESEARCH, 21, S352–S352.
Event: AMER SOC BONE & MINERAL RES 2025 M ST, NW, STE 800, WASHINGTON, DC 20036-3309 USA
Source: ORCID
Added: April 4, 2022
2005 journal article
Fan-beam densitometry of the growing skeleton
Journal of Clinical Densitometry, 8(1), 57–64.
Contributors: * , T. Scerpella * & M. Meulen *
author keywords: bone densitometry; fan-beam magnification; pediatric bone accrual; growth and development; clinical trial
MeSH headings : Absorptiometry, Photon / instrumentation; Absorptiometry, Photon / methods; Bone Density; Humans; Phantoms, Imaging; Radiographic Magnification
TL;DR:
Magnification error in fan-beam densitometers varies with distance from the X-ray source to the bone measured and might obscure bone mineral changes in the growing skeleton and be problematic for clinical studies using fan- beam densitometry.
(via Semantic Scholar)
Source: ORCID
Added: April 4, 2022
2005 journal article
Fan-beam densitometry of the growing skeleton: are we measuring what we think we are?
Journal of Clinical Densitometry, 8(1), 57–64.
Source: ORCID
Added: April 4, 2022
2005 journal article
Increased bone accrual in premenarcheal gymnasts: A longitudinal study
Pediatric Exercise Science, 17(2), 149–160. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000229381100005&KeyUID=WOS:000229381100005
Source: ORCID
Added: April 4, 2022
2004 journal article
Normal bone geometry but reduced bone mineral at the femoral neck with cystic fibrosis.
Journal of Bone and Mineral Research, 19, S237. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000224326801303&KeyUID=WOS:000224326801303
Source: ORCID
Added: April 4, 2022
2004 conference paper
Normal bone geometry but reduced bone mineral at the femoral neck with cystic fibrosis.
JOURNAL OF BONE AND MINERAL RESEARCH, 19, S237–S237.
Event: AMER SOC BONE & MINERAL RES 2025 M ST, NW, STE 800, WASHINGTON, DC 20036-3309 USA
Source: ORCID
Added: April 4, 2022
2004 conference paper
Use of a phantom to assess fan-beam magnification in clinical densitometry
Orthopaedic Research Society Annual Meeting, San Francisco, CA. Presented at the http://www.ors.org/Transactions/50/0990.pdf.
Event: http://www.ors.org/Transactions/50/0990.pdf
Source: ORCID
Added: April 4, 2022
2003 conference paper
Modest amounts of impact activity increase the rate of bone mineral accrual in pre-menarcheal gymnasts: a longitudinal study
Orthopaedic Research Society Annual Meeting, New Orleans, LA. Presented at the http://www.ors.org/Transactions/49/0406.pdf.
Event: http://www.ors.org/Transactions/49/0406.pdf
Source: ORCID
Added: April 4, 2022
2003 journal article
Patients with cystic fibrosis have normal bone geometry but reduced bone mineral.
Journal of Bone and Mineral Research, 18, S320. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000186080501284&KeyUID=WOS:000186080501284
Source: ORCID
Added: April 4, 2022
2003 conference paper
Patients with cystic fibrosis have normal bone geometry but reduced bone mineral.
JOURNAL OF BONE AND MINERAL RESEARCH, 18, S320–S320.
Event: AMER SOC BONE & MINERAL RES 2025 M ST, NW, STE 800, WASHINGTON, DC 20036-3309 USA
Source: ORCID
Added: April 4, 2022
Employment
Updated: August 16th, 2020 14:45
2020 - present
University of North Carolina and North Carolina State University Raleigh, NC, US
Associate Professor
Joint Department of Biomedical Engineering
2013 - 2020
University of North Carolina and North Carolina State University Raleigh, NC, US
Assistant Professor
Joint Department of Biomedical Engineering
Education
Updated: January 25th, 2020 19:41
2004 - 2007
Cornell University Ithaca, NY, US
Ph.D.
Mechanical Engineering
2001 - 2004
Cornell University Ithaca, NY, US
M.S.
Mechanical Engineering
1996 - 2001
Auburn University Auburn, AL, US
B.M.E.
Mechanical Engineering
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