John Michael Cullen

Assessment of Mouse Liver Histopathology Following Exposure to HFPO-DA With Emphasis on Understanding Mechanisms of Hepatocellular Death

Thompson, C. M., Heintz, M. M., Wolf, J. C., Cheru, R., Haws, L. C., & Cullen, J. M. (2023, March 29). TOXICOLOGIC PATHOLOGY.

Assessment of the mode of action underlying development of liver lesions in mice following oral exposure to HFPO-DA and relevance to humans

Heintz, M. M., Haws, L. C., Klaunig, J. E., Cullen, J. M., & Thompson, C. M. (2023, January 11). TOXICOLOGICAL SCIENCES.

Gallbladder microbiota in healthy dogs and dogs with mucocele formation

PLOS ONE, 18(2).

Histologic characterization of the major duodenal papilla and association with concurrent biliary, pancreatic, and intestinal pathology in cats

Schreeg, M. E., Cullen, J. M., Robertson, J., & Gookin, J. L. (2023, August 10). VETERINARY PATHOLOGY, Vol. 8.

Immunohistochemical characterization of clear cell variant of hepatocellular carcinoma in a sheep

JOURNAL OF COMPARATIVE PATHOLOGY, 204, 47–50.

Patent hepatic ciliated foregut remnant resulting in an umbilicobiliary sinus tract, with gallbladder agenesis, in an 8-wk-old male French Bulldog

Wong, H. E., Cullen, J. M., Vila-Gonzalez, M., Pittaway, R., Desmet, V. J., & Gillian, T. D. (2023, January 4). JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION.

Viral protease cleavage of MAVS in genetically modified mice with hepatitis A virus infection

JOURNAL OF HEPATOLOGY, 78(2), 271–280.

Hepatocellular carcinomas in captive prosimians

Robveille, C., & Cullen, J. M. (2022, July 25). VETERINARY PATHOLOGY.

The ZCCHC14/TENT4 complex is required for hepatitis A virus RNA synthesis

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119(28).

Choledochal cyst with secondary cholangitis, choledochitis, duodenal papillitis, and pancreatitis in a young domestic shorthair cat

Schreeg, M. E., Miller, S. A., & Cullen, J. M. (2021, May 24). JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION.

Ductal Plate Malformations in Captive Snakes

Patania, O. M., Troan, B. V., & Cullen, J. M. (2021, May 3). VETERINARY PATHOLOGY.

IRF3-mediated pathogenicity in a murine model of human hepatitis A

PLOS PATHOGENS, 17(9).

Iminosugar Glucosidase Inhibitors Reduce Hepatic Inflammation in Hepatitis A Virus-Infected Ifnar1(-/-) Mice

JOURNAL OF VIROLOGY, 95(11).

International Guidelines for Veterinary Tumor Pathology: A Call to Action

Meuten, D. J., Moore, F. M., Donovan, T. A., Bertram, C. A., Klopfleisch, R., Foster, R. A., … Whitley, D. (2021, July 20). VETERINARY PATHOLOGY.

International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of the Dog

[Review of ]. TOXICOLOGIC PATHOLOGY, 49(1), 5–109.

T cells protect against hepatitis A virus infection and limit infection- induced liver injury

JOURNAL OF HEPATOLOGY, 75(6), 1323–1334.

Using rheology to quantify the effects of localized collagenase treatments on uterine fibroid digestion

ACTA BIOMATERIALIA, 134, 443–452.

An adverse outcome pathway for small intestinal tumors in mice involving chronic cytotoxicity and regenerative hyperplasia: a case study with hexavalent chromium, captan, and folpet

[Review of ]. CRITICAL REVIEWS IN TOXICOLOGY, 50(8), 685–706.

Assessment of the Mode of Action Underlying the Effects of GenX in Mouse Liver and Implications for Assessing Human Health Risks

TOXICOLOGIC PATHOLOGY, 48(3), 494–508.

Inter-Institutional Partnerships to Develop Veterinarian-Investigators through the NIH Comparative Biomedical Scientist Training Program Benefit One Health Goals

JOURNAL OF VETERINARY MEDICAL EDUCATION, 47(5), 619–631.

Comparative Pathology of Hepatitis A Virus and Hepatitis E Virus Infection

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 9(4).

Computed Tomography of Lobular Dissecting Hepatitis in a Young Golden Retriever

JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION, 55(2).

Development of an oral reference dose for the perfluorinated compound GenX

JOURNAL OF APPLIED TOXICOLOGY, 39(9), 1267–1282.

Reevaluation of Hepatocellular Neoplasms in CD-1 Mice from a 2-year Oral Carcinogenicity Study with Permethrin

TOXICOLOGIC PATHOLOGY, 47(1), 11–17.

Virus discovery reveals frequent infection by diverse novel members of the Flaviviridae in wild lemurs

ARCHIVES OF VIROLOGY, 164(2), 509–522.

EVALUATION OF THE OPHTHALMIC DISEASE AND HISTOPATHOLOGIC EFFECTS DUE TO THE OCULAR TREMATODE PHILOPHTHALMUS ZALOPHI ON JUVENILE GALAPAGOS SEA LIONS (ZALOPHUS WOLLEBAEKI)

JOURNAL OF ZOO AND WILDLIFE MEDICINE, 49(3), 581–590.

Evaluation of potential serum biomarkers of hepatic fibrosis and necroinflammatory activity in dogs with liver disease

JOURNAL OF VETERINARY INTERNAL MEDICINE, 32(3), 1009–1018.

MORTALITY IN COQUEREL'S SIFAKAS (PROPITHECUS COQUERELI) UNDER HUMAN CARE: A RETROSPECTIVE SURVEY FROM THE DUKE LEMUR CENTER 1990-2015

JOURNAL OF ZOO AND WILDLIFE MEDICINE, 49(2), 315–323.

New parvovirus associated with serum hepatitis in horses after inoculation of common biological product

Emerging Infectious Diseases, 24(2), 303–310.

Qualitative metabolomics profiling of serum and bile from dogs with gallbladder mucocele formation

PLOS ONE, 13(1).

Viral persistence, liver disease, and host response in a hepatitis C-like virus rat model

Hepatology, 68(2), 435–448.

Interobserver Agreement Using Histological Scoring of the Canine

JOURNAL OF VETERINARY INTERNAL MEDICINE, 31(3), 778–783.

MYCOBACTERIUM INTRACELLULARE INFECTION CAUSING A RETROPERITONEAL MASS IN A BINTURONG (ARCTICTIS BINTURONG)

JOURNAL OF ZOO AND WILDLIFE MEDICINE, 48(2), 544–548.

Mouse models of acute and chronic hepacivirus infection

SCIENCE, 357(6347), 204-+.

Other viruses: Hepeviridae, hepadnaviridae, deltaviruses, nodaviridae, and unclassified viruses

Fenner's Veterinary Virology, 5th Edition, 547–555.

TIM1 (HAVCR1) Is Not Essential for Cellular Entry of Either Quasi-enveloped or Naked Hepatitis A Virions

MBIO, 8(5).

Acute Alpha-Naphthylisothiocyanate-induced Liver Toxicity in Germfree and Conventional Male Rats

TOXICOLOGIC PATHOLOGY, 44(7), 987–997.

External beam radiation therapy of squamous cell carcinoma in the beak of an African grey parrot (Psittacus timneh)

Journal of Avian Medicine and Surgery, 30(3), 250–256.

Histiocytic chorioretinitis in a dog

Veterinary Ophthalmology, 21(1), 88–95.

Histology Atlas of the Developing Mouse Hepatobiliary Hemolymphatic Vascular System with Emphasis on Embryonic Days 11.5-18.5 and Early Postnatal Development

TOXICOLOGIC PATHOLOGY, 44(5), 705–725.

MAVS-dependent host species range and pathogenicity of human hepatitis A virus

SCIENCE, 353(6307), 1541–1545.

Reevaluation and Classification of Duodenal Lesions in B6C3F1 Mice and F344 Rats from 4 Studies of Hexavalent Chromium in Drinking Water

TOXICOLOGIC PATHOLOGY, 44(2), 279–289.

The Strange, Expanding World of Animal Hepaciviruses

ANNUAL REVIEW OF VIROLOGY, VOL 3, Vol. 3, pp. 53–75.

Association of Gallbladder Mucocele Histologic Diagnosis with Selected Drug Use in Dogs: A Matched Case-Control Study

JOURNAL OF VETERINARY INTERNAL MEDICINE, 29(6), 1464–1472.

Canine urothelial carcinoma: genomically aberrant and comparatively relevant

Chromosome Research, 23(2), 311–331.

Clinical, histopathological and immunohistochemical characterization of a novel equine ocular disorder: heterochromic iridocyclitis with secondary keratitis in adult horses

VETERINARY OPHTHALMOLOGY, 18(6), 443–456.

Effects of azathioprine, 6-mercaptopurine, and 6-thioguanine on canine primary hepatocytes

AMERICAN JOURNAL OF VETERINARY RESEARCH, 76(7), 649–655.

Excess Secretion of Gel-Forming Mucins and Associated Innate Defense Proteins with Defective Mucin Un-Packaging Underpin Gallbladder Mucocele Formation in Dogs

PLOS ONE, 10(9).

Biliary Proliferative Lesions in the Sprague-Dawley Rat: Adverse/Non-adverse

TOXICOLOGIC PATHOLOGY, 42(5), 844–854.

Effects of excess dietary fructose on liver pathology study have significant methodologic limitations: Reply

Evaluation of fluorescence in situ hybridization for the detection of bacteria in feline inflammatory liver disease

JOURNAL OF FELINE MEDICINE AND SURGERY, 16(2), 109–117.

Hyperinsulinemic Hypoglycemia Syndrome in 2 Dogs with Bartonellosis

Journal of Veterinary Internal Medicine, 28(4), 1331–1335.

Lack of association of ABCB4 insertion mutation with gallbladder mucoceles in dogs

JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, 26(3), 434–436.

Liver biomarker and in vitro assessment confirm the hepatic origin of aminotransferase elevations lacking histopathological correlate in beagle dogs treated with GABA(A) receptor antagonist NP260

TOXICOLOGY AND APPLIED PHARMACOLOGY, 277(2), 131–137.

Role of Pregnane X Receptor in Obesity and Glucose Homeostasis in Male Mice

JOURNAL OF BIOLOGICAL CHEMISTRY, 289(6), 3244–3261.

Role of human pregnane X receptor in high fat diet-induced obesity in pre-menopausal female mice

BIOCHEMICAL PHARMACOLOGY, 89(3), 399–412.

Thymofibrolipoma in a Labrador Retriever

VETERINARY PATHOLOGY, 51(4), 816–819.

Visualizing surface area and volume of lumens in three dimensions using images from histological sections

JOURNAL OF MICROSCOPY, 256(3), 190–196.

Cardiac structure and function in female carrier's of a canine model of Duchenne muscular dystrophy

RESEARCH IN VETERINARY SCIENCE, 94(3), 610–617.

Chikungunya Virus Host Range E2 Transmembrane Deletion Mutants Induce Protective Immunity against Challenge in C57BL/6J Mice

JOURNAL OF VIROLOGY, 87(12), 6748–6757.

Dietary fructose induces endotoxemia and hepatic injury in calorically controlled primates

AMERICAN JOURNAL OF CLINICAL NUTRITION, 98(2), 349–357.

From Bipeds to an Honorary Member of the American College of Veterinary Pathologists

Meuten, D. J., Law, J. M., Stromberg, P. C., & Cullen, J. M. (2013, May).

Granulomatous metritis caused by suspected Dirofilaria immitis in a dog: a case report

VETERINARNI MEDICINA, 58(8), 437–441.

Necrolytic migratory erythema associated with a glucagon-producing primary hepatic neuroendocrine carcinoma in a cat

VETERINARY DERMATOLOGY, 24(4), 466–E110.

Primate fructose study misses mark due to preventable design flaws Reply

Cutting Through to the Truth: Laser Capture Microscopy and Acute Toxic Biliary Injury

Journal of Comparative Pathology, 146(1), 45.

Evaluation of diode endoscopic cyclophotocoagulation in bovine cadaver eyes

AMERICAN JOURNAL OF VETERINARY RESEARCH, 73(9), 1445–1452.

Limited yield of diagnoses of intrahepatic infectious causes of canine granulomatous hepatitis from archival liver tissue

Journal of Veterinary Diagnostic Investigation, 24(5), 888–894.

Reye's or Reye's-like syndrome in western lowland gorilla (Gorilla gorilla gorilla)

JOURNAL OF MEDICAL PRIMATOLOGY, 41(5), 329–331.

Serology-Enabled Discovery of Genetically Diverse Hepaciviruses in a New Host

JOURNAL OF VIROLOGY, 86(11), 6171–6178.

Development of an Animal Model for Radiofrequency Ablation of Primary, Virally Induced Hepatocellular Carcinoma in the Woodchuck

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 22(11), 1613–1618.

H-ras Consensus Sequence and Mutations in Primary Hepatocellular Carcinomas of Lemurs and Lorises

VETERINARY PATHOLOGY, 48(4), 868–874.

Molecular cytogenetic characterization of canine histiocytic sarcoma: A spontaneous model for human histiocytic cancer identifies deletion of tumor suppressor genes and highlights influence of genetic background on tumor behavior

BMC Cancer, 11.

Necropsy or Autopsy? It’s All About Communication!

Veterinary Pathology, 49(2), 271–272.

Recommended guidelines for submission, trimming, margin evaluation, and reporting of tumor biopsy specimens in veterinary surgical pathology

Veterinary Pathology, 48(1), 19–31.

Recommended guidelines for the conduct and evaluation of prognostic studies in veterinary oncology

Veterinary Pathology, 48(1), 7–18.

Acute ANIT Toxicity in Male IL-10 Knockout and Wild-type Mice

TOXICOLOGIC PATHOLOGY, 38(5), 745–755.

Congenital Hepatic Fibrosis in 5 Dogs

VETERINARY PATHOLOGY, 47(1), 102–107.

Imaging diagnosis-neuronal ceroid lipofuscinosis with a chronic subdural hematoma

Veterinary Radiology & Ultrasound, 51(2), 155–158.

Spontaneous Hepatocellular Carcinoma in Captive Prosimians

VETERINARY PATHOLOGY, 47(2), 306–311.

Time Course Gene Expression Using Laser Capture Microscopy-Extracted Bile Ducts, but Not Hepatic Parenchyma, Reveals Acute Alpha-Naphthylisothiocyanate Toxicity

TOXICOLOGIC PATHOLOGY, 38(5), 715–729.

ACQUIRED ARTERIOVENOUS FISTULA IN A GRIZZLY BEAR (URSUS ARCTOS HORRIBILIS)

JOURNAL OF ZOO AND WILDLIFE MEDICINE, 40(1), 193–195.

Aflatoxin B1 and/or Hepatitis B Virus Induced Tumor Spectrum in a Genetically Engineered Hepatitis B Virus Expression and Trp53 Haploinsufficient Mouse Model System for Hepatocarcinogenesis

TOXICOLOGIC PATHOLOGY, 37(3), 333–342.

Microarray-based cytogenetic profiling reveals recurrent and subtype-associated genomic copy number aberrations in feline sarcomas

CHROMOSOME RESEARCH, 17(8), 987–1000.

Summary of the World Small Animal Veterinary Association Standardization Committee Guide to Classification of Liver Disease in Dogs and Cats

VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE, 39(3), 395-+.

Expression of CDK4 or CDK2 in mouse oral cavity is retained in adult pituitary with distinct effects on tumorigenesis

CANCER RESEARCH, 68(1), 162–171.

Harderian gland neoplasms in captive, wild-caught Beechey ground squirrels (Spermophilus beecheyi)

VETERINARY PATHOLOGY, 45(3), 388–392.

Serologic survey of woodchuck hepatitis virus in North Carolina woodchucks (Marmota monax)

JOURNAL OF ZOO AND WILDLIFE MEDICINE, 39(2), 263–265.

Selective deletion of antigen-specific CD8(+) T cells by MHC class I tetramers, coupled to the type I ribosome-inactivating protein saporin

BLOOD, 109(8), 3300–3307.

The liver of woodchucks chronically infected with the woodchuck hepatitis virus contains foci of virus core antigen-negative hepatocytes with both altered and normal morphology

VIROLOGY, 359(2), 283–294.

Fall panicum (Panicum dichotomiflorum) hepatotoxicosis in horses and sheep

JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 20, pp. 1414–1421.

P.050 Appearance of core antigen negative hepatocytes in woodchucks chronically infected with woodchuck hepatitis virus

Journal of Clinical Virology, 36, S76.

The role of pathology in the identification of drug-induced hepatic toxicity

[Review of ]. EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 2(2), 241–247.

CDNA microarray analysis of HBV transgenic mouse liver identifies genes in lipid biosynthetic and growth control pathways affected by HBV

JOURNAL OF MEDICAL VIROLOGY, 77(1), 57–65.

Mechanistic Classification of Liver Injury

Toxicologic Pathology, 33(1), 6–8.

Paraneoplastic pemphigus in a dog with splenic sarcoma

VETERINARY PATHOLOGY, 42(1), 88–91.

Adenovirus-based gene therapy during clevudine treatment of woodchucks chronically infected with woodchuck hepatitis virus

VIROLOGY, 327(1), 26–40.

Woodchuck interleukin-6 gene: structure,characterization, and biologic activity

GENE, 342(1), 157–164.

Detection of Bartonella henselae and Bartonella clarridgeiae DNA in hepatic specimens from two dogs with hepatic disease

Journal of the American Veterinary Medical Association, 222(1), 47–51.

Helicobacter marmotae sp nov isolated from livers of woodchucks and intestines of cats

JOURNAL OF CLINICAL MICROBIOLOGY, 40(7), 2513–2519.

Antiviral efficacy and pharmacokinetics of oral adefovir dipivoxil in chronically woodchuck hepatitis virus-infected woodchucks

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 45(10), 2740–2745.

Idiopathic noncirrhotic portal hypertension in dogs: 33 cases (1982-1998)

Bunch, S. E., Johnson, S. E., & Cullen, J. M. (2001, February 1). JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 218, pp. 392–399.

Kinetics of hepadnavirus loss from the liver during inhibition of viral DNA synthesis

JOURNAL OF VIROLOGY, 75(1), 311–322.

T-helper cell response to woodchuck hepatitis virus antigens after therapeutic vaccination of chronically-infected animals treated with lamivudine

JOURNAL OF HEPATOLOGY, 35(1), 105–111.