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Works (120)
Updated: April 4th, 2024 19:32
2024 journal article
Reply to Piewbang et al. Domestic Cat Hepadnavirus Antigens in Lymphoma Tissues. Comment on "Beatty et al. Domestic Cat Hepadnavirus and Lymphoma. <i>Viruses</i> 2023, <i>15</i>, 2294"
VIRUSES-BASEL, 16(1).
www.mdpi.com (publisher PDF)
Source: Web Of Science
Added: February 12, 2024
2023 article
Assessment of Mouse Liver Histopathology Following Exposure to HFPO-DA With Emphasis on Understanding Mechanisms of Hepatocellular Death
Thompson, C. M., Heintz, M. M., Wolf, J. C., Cheru, R., Haws, L. C., & Cullen, J. M. (2023, March 29). TOXICOLOGIC PATHOLOGY.
author keywords: liver; liver pathology; GenX; HFPO-DA; per- and polyfluoroalkyl substances (PFAS); peroxisome proliferator
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
6. Clean Water and Sanitation
(Web of Science)
Source: Web Of Science
Added: April 24, 2023
2023 article
Assessment of the mode of action underlying development of liver lesions in mice following oral exposure to HFPO-DA and relevance to humans
Heintz, M. M., Haws, L. C., Klaunig, J. E., Cullen, J. M., & Thompson, C. M. (2023, January 11). TOXICOLOGICAL SCIENCES.
author keywords: mode of action (MOA); liver; peroxisome proliferator-activated receptor alpha; (PPAR alpha); HFPO-DA (GenX); PFAS
MeSH headings : Humans; Mice; Animals; PPAR alpha / genetics; PPAR alpha / metabolism; Fluorocarbons / toxicity; Liver; Liver Neoplasms / metabolism; Rodentia / metabolism
TL;DR:
The adverse effects observed in rodent livers should not be used as the basis of toxicity values for HFPO-DA for purposes of human health risk assessment, because only KE 1, PPARα activation, is shared across species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Source: Web Of Science
Added: February 27, 2023
2023 journal article
Distinct disease features of acute and persistent genotype 3 hepatitis E virus infection in immunocompetent and immunosuppressed Mongolian gerbils
PLOS PATHOGENS, 19(9).
TL;DR:
The studies show that Mongolian gerbils provide a promising model to study pathogenesis during acute and persistentHEV infection and suggest adaptive immune responses are necessary for inducing hepatocyte apoptosis, CD68+ macrophage recruitment, and inflammatory cell infiltration in response to HEV infection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: October 2, 2023
2023 article
Domestic Cat Hepadnavirus and Lymphoma
Beatty, J. A., Tu, T., Pesavento, P. A., Cavasin, J. P., Chen, M.-C., Lidbury, J. A., … Cullen, J. M. (2023, December). VIRUSES-BASEL, Vol. 15.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Web Of Science
Added: January 8, 2024
2023 journal article
Eosinophilic pericardial effusion and pericarditis in a cat
JOURNAL OF FELINE MEDICINE AND SURGERY OPEN REPORTS, 9(2).
author keywords: Apicomplexan; Bartonella; eosinophilic effusion; mesothelial cells; pericardial effusion; pericarditis
TL;DR:
This case offers several unique entities and illustrates the well-known marked atypia that may occur in reactive and hyperplastic mesothelial cells, particularly of infrequently sampled and cytologically described feline pericardial effusion, supporting a cautious interpretation of this cytology finding.
(via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: December 18, 2023
2023 journal article
Gallbladder microbiota in healthy dogs and dogs with mucocele formation
PLOS ONE, 18(2).
MeSH headings : Dogs; Animals; Gallbladder / pathology; Mucocele / veterinary; RNA, Ribosomal, 16S / genetics; Bile / microbiology; Gallbladder Diseases / veterinary; Microbiota / genetics; Bile Duct Diseases; Dog Diseases / diagnosis
TL;DR:
Results of this study do not support existence of a core microbiome in the bile of healthy dogs or gallbladder mucus from dogs with mucocele formation, and document how contaminating sequences can significantly contribute to the results of sequencing analysis when performed on samples with low bacterial biomass.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID
Added: April 24, 2023
2023 article
Histologic characterization of the major duodenal papilla and association with concurrent biliary, pancreatic, and intestinal pathology in cats
Schreeg, M. E., Cullen, J. M., Robertson, J., & Gookin, J. L. (2023, August 10). VETERINARY PATHOLOGY, Vol. 8.
author keywords: ampulla of Vater; cat; cholangitis; enteritis; lymphoma; major duodenal papillitis; pancreatitis
TL;DR:
Ass associations between MDP anatomy/disease and the presence of biliary, pancreatic, or intestinal inflammation or neoplasia are identified and suggest that anatomy, immune activation, and/or inflammation of the MDP may play a role in the pathogenesis of triaditis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 21, 2023
2023 journal article
Immunohistochemical characterization of clear cell variant of hepatocellular carcinoma in a sheep
JOURNAL OF COMPARATIVE PATHOLOGY, 204, 47–50.
author keywords: arginase 1; clear cell; hepatocellular carcinoma; liver; pathology; sheep; tumour
TL;DR:
The cadaver and viscera of a mature female sheep underwent routine abattoir meat inspection and the neoplasm was diagnosed as the clear cell variant of a hepatocellular carcinoma.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 28, 2023
2023 article
Patent hepatic ciliated foregut remnant resulting in an umbilicobiliary sinus tract, with gallbladder agenesis, in an 8-wk-old male French Bulldog
Wong, H. E., Cullen, J. M., Vila-Gonzalez, M., Pittaway, R., Desmet, V. J., & Gillian, T. D. (2023, January 4). JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION.
author keywords: agenesis; cilia; cysts; dogs; embryonic structures; foregut remnant; fluorescent antibody technique; gallbladder; liver
MeSH headings : Animals; Dogs; Male; Cilia / pathology; Dog Diseases / diagnosis; Dog Diseases / surgery; Dog Diseases / pathology; Gallbladder / pathology; Inflammation / pathology; Inflammation / veterinary; Liver Diseases / pathology; Liver Diseases / veterinary
TL;DR:
A case of an 8-wk-old male French Bulldog with a congenital patent hepatic ciliated foregut remnant resulting in an umbilicobiliary sinus tract and therapeutic resolution of the clinical signs is described.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: January 23, 2023
2023 journal article
Phenotype and fate of liver-resident CD8 T cells during acute and chronic hepacivirus infection
PLOS PATHOGENS, 19(10).
TL;DR:
MHC class I and class II tetramers are developed to characterize the serial changes in RHV-specific CD8 and CD4 T cells during acute and chronic infection in C57BL/6J mice.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Web Of Science
Added: November 6, 2023
2023 article
Severe bronchiectasis resulting from chronic bacterial bronchitis and bronchopneumonia in a jungle cat
Kang, D., Womble, M., Cullen, J. M., Harrison, T. M., Premanandan, C., & Schreeg, M. E. (2023, November 28). JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, Vol. 11.
author keywords: Escherichia coli; exotic animal; Felidae; lung; Proteus; respiratory disease; zoo animal
TL;DR:
Chronic bronchitis and bronchopneumonia should be considered as a cause of bronchiectasis and a differential diagnosis for respiratory disease in non-domestic felids.
(via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: December 18, 2023
2023 journal article
Viral protease cleavage of MAVS in genetically modified mice with hepatitis A virus infection
JOURNAL OF HEPATOLOGY, 78(2), 271–280.
author keywords: Innate immunity; Species barrier; Interferon; Animal model; 3ABC protease; inflammation; Viral replication; CRISPR
MeSH headings : Animals; Mice; Humans; Hepatitis A virus / genetics; Peptide Hydrolases; Mice, Inbred C57BL; Hepatitis A; Immunity, Innate; Viral Proteases
TL;DR:
It is shown that HAV 3ABC protease cleavage of MAVS enhances viral replication and lessens liver inflammation in mice lacking interferon receptors, but that it is insufficient by itself to overcome the cross-species barrier to infection in mice.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Source: Web Of Science
Added: April 24, 2023
2022 article
Hepatocellular carcinomas in captive prosimians
Robveille, C., & Cullen, J. M. (2022, July 25). VETERINARY PATHOLOGY.
author keywords: hepatocellular carcinoma; lemur; metastasis; neoplasm; prosimians; cytokeratin 7; cytokeratin 19
MeSH headings : Animals; Biomarkers, Tumor; Carcinoma, Hepatocellular / diagnosis; Carcinoma, Hepatocellular / veterinary; Immunohistochemistry; Keratin-19; Keratin-7; Liver Neoplasms / diagnosis; Liver Neoplasms / veterinary; Paraffin; Retrospective Studies; Strepsirhini
TL;DR:
A retrospective examination of spontaneous hepatocellular carcinomas (HCCs) in 14 captive prosimians brought to the Veterinary Medical Diagnostic Laboratory in North Carolina State University over a period of 11 years suggests that K7 might be a prognostically relevant marker in HCCs of captive Prosimians.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Source: Web Of Science
Added: August 1, 2022
2022 journal article
The ZCCHC14/TENT4 complex is required for hepatitis A virus RNA synthesis
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119(28).
author keywords: picornavirus; antiviral therapy; animal model; hepatitis A; RNA-binding protein
MeSH headings : Animals; Antiviral Agents / pharmacology; Antiviral Agents / therapeutic use; Chromosomal Proteins, Non-Histone / metabolism; DNA-Directed DNA Polymerase / metabolism; Hepatitis A / drug therapy; Hepatitis A / metabolism; Hepatitis A / virology; Hepatitis A virus / drug effects; Hepatitis A virus / genetics; Hepatitis A virus / physiology; Humans; Intrinsically Disordered Proteins / metabolism; Mice; Mice, Mutant Strains; RNA Nucleotidyltransferases / metabolism; RNA, Viral / biosynthesis; RNA, Viral / genetics; Receptor, Interferon alpha-beta / genetics; Virus Replication / drug effects
TL;DR:
It is demonstrated that targeting the RNA genome of this unique, hepatotropic picornavirus with an orally delivered small-molecule therapeutic ablates viral replication and reverses liver inflammation in a mouse model of hepatitis A, providing proof-of-principle for antiviral therapy and showing the potential for chemoprevention of hepatitis B in outbreak settings.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: September 29, 2022
2021 article
Choledochal cyst with secondary cholangitis, choledochitis, duodenal papillitis, and pancreatitis in a young domestic shorthair cat
Schreeg, M. E., Miller, S. A., & Cullen, J. M. (2021, May 24). JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION.
author keywords: bile ducts; cats; cholangitis; choledochal cyst; congenital; liver; pancreatitis
MeSH headings : Animals; Cat Diseases / diagnosis; Cat Diseases / pathology; Cats; Cholangitis / diagnosis; Cholangitis / etiology; Cholangitis / veterinary; Choledochal Cyst / complications; Choledochal Cyst / veterinary; Duodenal Diseases / diagnosis; Duodenal Diseases / etiology; Duodenal Diseases / veterinary; Female; Pancreatitis / diagnosis; Pancreatitis / etiology; Pancreatitis / veterinary
TL;DR:
Choledochal cysts can be associated with chronic neutrophilic cholangitis, extrahepatic obstruction, choledochitis, duodenal papillitis, and pancreatitis and should be a differential for increased hepatic enzymes and hyperbilirubinemia in young cats.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: June 10, 2021
2021 article
Ductal Plate Malformations in Captive Snakes
Patania, O. M., Troan, B. V., & Cullen, J. M. (2021, May 3). VETERINARY PATHOLOGY.
author keywords: bile ducts; ductal plate malformation; immunohistochemistry; liver; polycystic liver disease; snake; von Meyenburg complex
MeSH headings : Animals; Bile Ducts; Bile Ducts, Intrahepatic; Cysts / veterinary; Liver Diseases / veterinary; Snakes
TL;DR:
Histochemical and immunohistochemical staining, including Gomori’s trichome and pan-cytokeratin, respectively, were applied on select cases to confirm histologic features of ductal plate malformations in captive snakes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: June 14, 2021
2021 journal article
IRF3-mediated pathogenicity in a murine model of human hepatitis A
PLOS PATHOGENS, 17(9).
MeSH headings : Animals; Disease Models, Animal; Hepatitis A / metabolism; Hepatitis A / pathology; Interferon Regulatory Factor-3 / metabolism; Liver / pathology; Mice; Mice, Knockout; Transcriptome
TL;DR:
It is shown that IRF 3-mediated transcription is required for HAV-induced liver injury in mice and key IRF3-responsive genes associated with pathogenicity are identified, providing a clear distinction from the transcription-independent role of IRf3 in liver injury following binge exposure to alcohol.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: February 28, 2022
2021 journal article
Iminosugar Glucosidase Inhibitors Reduce Hepatic Inflammation in Hepatitis A Virus-Infected Ifnar1(-/-) Mice
JOURNAL OF VIROLOGY, 95(11).
author keywords: antiviral agents; ganglioside; hepatitis A virus; host response; iminosugar; liver immunology; miglustat; picornavirus
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: June 10, 2021
2021 article
International Guidelines for Veterinary Tumor Pathology: A Call to Action
Meuten, D. J., Moore, F. M., Donovan, T. A., Bertram, C. A., Klopfleisch, R., Foster, R. A., … Whitley, D. (2021, July 20). VETERINARY PATHOLOGY.
author keywords: standardization; oncology; guidelines; protocols; validation
MeSH headings : Animals; Neoplasms / diagnosis; Neoplasms / veterinary; Pathology, Veterinary; Reproducibility of Results
TL;DR:
This initiative is a continuation of efforts published in this journal in 2011 and it is hoped that this initiative will facilitate collaboration and reproducibility between pathologists and institutions, increase case numbers, and strengthen clinical research findings, thus ensuring continued progress in veterinary oncologic pathology and improving patient care.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 2, 2021
2021 review
International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of the Dog
[Review of ]. TOXICOLOGIC PATHOLOGY, 49(1), 5–109.
author keywords: dog; pathology; toxicopathology; nomenclature; background findings; INHAND
MeSH headings : Animals; Animals, Laboratory; Databases, Factual; Dogs; Europe; Japan
TL;DR:
A standardized nomenclature for classifying lesions observed in most tissues and organs from the dog used in nonclinical safety studies is provided and some of the lesions are illustrated by color photomicrographs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: Web Of Science
Added: February 1, 2021
2021 journal article
T cells protect against hepatitis A virus infection and limit infection- induced liver injury
JOURNAL OF HEPATOLOGY, 75(6), 1323–1334.
author keywords: Hepatitis A Virus; mice; liver infection; liver pathogenesis; T cells; T cell vaccine; type-1 interferons
MeSH headings : Analysis of Variance; Animals; Disease Models, Animal; Hepatitis A / drug therapy; Hepatitis A / epidemiology; Hepatitis A / prevention & control; Hepatitis A virus / drug effects; Hepatitis A virus / pathogenicity; Liver Diseases / drug therapy; Liver Diseases / epidemiology; Liver Diseases / prevention & control; Mice; North Carolina; Statistics, Nonparametric; T-Lymphocytes / metabolism; T-Lymphocytes / physiology
TL;DR:
It is shown that T cells protect against HAV-mediated liver injury and can be targeted to improve liver health.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: December 13, 2021
2021 journal article
Using rheology to quantify the effects of localized collagenase treatments on uterine fibroid digestion
ACTA BIOMATERIALIA, 134, 443–452.
author keywords: Uterine fibroids; Collagenase; Drug delivery; Rheology; Histology
MeSH headings : Animals; Collagenases; Digestion; Female; Humans; Leiomyoma / drug therapy; Mice; Rheology; Treatment Outcome; Uterine Neoplasms
TL;DR:
Rheological results from an in vivo digestion study in mice show a significant reduction in tissue modulus and increase in tissue viscoelasticity 7 days after a single injection of LQG+CCH, and show promise for development of injectable and localized enzymatic therapies for uterine fibroids and other dense tumors.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: November 8, 2021
2020 review
An adverse outcome pathway for small intestinal tumors in mice involving chronic cytotoxicity and regenerative hyperplasia: a case study with hexavalent chromium, captan, and folpet
[Review of ]. CRITICAL REVIEWS IN TOXICOLOGY, 50(8), 685–706.
author keywords: Adverse outcome pathway (AOP); small intestinal tumors; villous cytotoxicity; regenerative proliferation; crypt hyperplasia; cytotoxicity-mediated; non-DNA-reactive; mode of action (MOA); weight of evidence; hexavalent chromium; captan; folpet
MeSH headings : Adverse Outcome Pathways; Animals; Captan / toxicity; Chromium / toxicity; Duodenum; Fungicides, Industrial / toxicity; Humans; Hyperplasia; Intestinal Neoplasms / chemically induced; Mice; Phthalimides / toxicity; Risk Assessment
TL;DR:
The extensive evidence for this AOP, along with the knowledge that human exposures are orders of magnitude below those associated with KEs, supports its use for regulatory applications, including hazard identification and risk assessment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: November 24, 2020
2020 journal article
Assessment of the Mode of Action Underlying the Effects of GenX in Mouse Liver and Implications for Assessing Human Health Risks
TOXICOLOGIC PATHOLOGY, 48(3), 494–508.
author keywords: transcriptomics; perfluoroalkyl and polyfluoroalkyl substances (PFAS); GenX; mode of action; single-cell necrosis; peroxisome proliferator-activated receptor alpha (PPAR alpha)
MeSH headings : Animals; Female; Humans; Hydrocarbons, Fluorinated / toxicity; Liver / drug effects; Male; Mice; PPAR alpha / drug effects; Propionates / toxicity; Risk Assessment; Transcriptome / drug effects
TL;DR:
Results indicate that the liver changes observed in GenX-treated mice occur via a mode of action (MOA) involving PPARα, an important finding for human health risk assessment as this MOA has limited relevance to humans.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Source: Web Of Science
Added: April 20, 2020
2020 journal article
Inter-Institutional Partnerships to Develop Veterinarian-Investigators through the NIH Comparative Biomedical Scientist Training Program Benefit One Health Goals
JOURNAL OF VETERINARY MEDICAL EDUCATION, 47(5), 619–631.
author keywords: clinician-scientist; graduate education; veterinary medical education; investigative pathologist; veterinary specialty; veterinary pathology; DVM/PhD; comparative medicine; predictive translational modeling; NIH intramural research training award (IRTA); NCI cancer research training award (CRTA)
MeSH headings : Animals; Biomedical Research; Education, Veterinary; Goals; Humans; National Institutes of Health (U.S.); One Health; United States; Veterinarians
TL;DR:
The CBSTP represents an inter-institutional opportunity that not only addresses critical needs for veterinarians in the biomedical workforce, but also simultaneously exposes national policy makers to veterinarian-scientists' specialized training, leading to more effective realization of One Health goals to benefit human and animal health.
(via Semantic Scholar)
Source: Web Of Science
Added: December 21, 2020
2019 journal article
Comparative Pathology of Hepatitis A Virus and Hepatitis E Virus Infection
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 9(4).
MeSH headings : Animals; Disease Models, Animal; Hepatitis A / pathology; Hepatitis A / virology; Hepatitis A virus; Hepatitis E / pathology; Hepatitis E / virology; Hepatitis E virus; Humans; Liver / pathology; Phylogeny; Primates
TL;DR:
In general, animals infected with these viruses recapitulate the histologic lesions seen in infected humans, but typically with less severe clinical and histopathological manifestations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: April 15, 2019
2019 journal article
Computed Tomography of Lobular Dissecting Hepatitis in a Young Golden Retriever
JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION, 55(2).
MeSH headings : Aging; Amoxicillin / therapeutic use; Animal Feed / analysis; Animals; Anti-Bacterial Agents / therapeutic use; Dietary Proteins / administration & dosage; Dog Diseases / diagnostic imaging; Dog Diseases / etiology; Dog Diseases / pathology; Dog Diseases / therapy; Dogs; Female; Gastrointestinal Agents / therapeutic use; Hepatic Encephalopathy / drug therapy; Hepatic Encephalopathy / etiology; Hepatic Encephalopathy / veterinary; Hepatitis, Animal / complications; Hepatitis, Animal / diagnostic imaging; Hepatitis, Animal / pathology; Hepatitis, Animal / therapy; Lactulose / therapeutic use; Liver / diagnostic imaging; Liver / pathology; Omeprazole / therapeutic use; Tomography, X-Ray Computed / veterinary
TL;DR:
Histologic evaluation of percutaneous needle biopsy samples of a liver nodule showed a rare form of hepatitis called lobular dissecting hepatitis, which should be considered as a differential in young dogs with precontrast hyperattenuating hepatic nodules on noncontrast-enhanced computed tomography.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: March 4, 2019
2019 journal article
Development of an oral reference dose for the perfluorinated compound GenX
JOURNAL OF APPLIED TOXICOLOGY, 39(9), 1267–1282.
author keywords: benchmark dose (BMD) modeling; GenX; per- and polyfluoroalkyl substances (PFAS); reference dose (RfD); risk assessment
MeSH headings : Animals; Benchmarking; Drinking Water / standards; Humans; Hydrocarbons, Fluorinated / toxicity; Lethal Dose 50; Models, Animal; No-Observed-Adverse-Effect Level; Propionates / toxicity; Rats; Reference Standards; United States; Water Pollutants, Chemical / toxicity
TL;DR:
A non‐cancer oral reference dose (RfD) for GenX is developed based on available repeated dose studies and it is anticipated that these values, along with the hazard identification and dose‐response modeling described herein, should be informative for risk assessors and regulators interested in setting health‐protective drinking water guideline values for Gen X.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science; OpenAlex)
Source: Web Of Science
Added: September 9, 2019
2019 journal article
Reevaluation of Hepatocellular Neoplasms in CD-1 Mice from a 2-year Oral Carcinogenicity Study with Permethrin
TOXICOLOGIC PATHOLOGY, 47(1), 11–17.
author keywords: permethrin; liver neoplasms; hepatocellular adenoma; hepatocellular carcinoma; Pathology Working Group
MeSH headings : Administration, Oral; Animals; Carcinogenicity Tests; Carcinogens / toxicity; Dose-Response Relationship, Drug; Female; Liver Neoplasms / chemically induced; Liver Neoplasms / pathology; Liver Neoplasms, Experimental / chemically induced; Liver Neoplasms, Experimental / pathology; Male; Mice, Inbred Strains; Permethrin / toxicity; Sex Factors
TL;DR:
An expert panel of pathologists was convened as a Pathology Working Group (PWG) to review coded liver histology sections from male and female mice and to classify all liver neoplasms according to current nomenclature and diagnostic criteria guidelines, which indicate that permethrin induced a significant dose-dependent increase in the incidence of hepatocellular neoplasm in treated female mice.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
11. Sustainable Cities and Communities
(Web of Science)
Source: Web Of Science
Added: February 11, 2019
2019 journal article
Virus discovery reveals frequent infection by diverse novel members of the Flaviviridae in wild lemurs
ARCHIVES OF VIROLOGY, 164(2), 509–522.
MeSH headings : Animals; Flaviviridae / classification; Flaviviridae / genetics; Flaviviridae / isolation & purification; Flaviviridae / physiology; Flaviviridae Infections / veterinary; Flaviviridae Infections / virology; Genetic Variation; Lemur / virology; Madagascar; Phylogeny; Primate Diseases / virology
TL;DR:
The results support the current proposed model of virus-host co-divergence with frequent occurrence of cross-species transmission for these genera and highlight how the discovery of more members of the Flaviviridae can help clarify the ecology and evolutionary history of these viruses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Source: Web Of Science
Added: March 4, 2019
2018 journal article
EVALUATION OF THE OPHTHALMIC DISEASE AND HISTOPATHOLOGIC EFFECTS DUE TO THE OCULAR TREMATODE PHILOPHTHALMUS ZALOPHI ON JUVENILE GALAPAGOS SEA LIONS (ZALOPHUS WOLLEBAEKI)
JOURNAL OF ZOO AND WILDLIFE MEDICINE, 49(3), 581–590.
author keywords: Conjunctival biopsy; eye trematode; Galapagos sea lion; Philophthalmus zalophi; Zalophus wollebaeki
MeSH headings : Aging; Animals; Ecuador / epidemiology; Eye Diseases / epidemiology; Eye Diseases / parasitology; Eye Diseases / veterinary; Sea Lions / parasitology; Trematoda / classification; Trematode Infections / epidemiology; Trematode Infections / parasitology; Trematode Infections / veterinary
TL;DR:
The histopathologic changes and gross lesions were likely due to the parasite's attachment to the conjunctiva, and further research is warranted to detail the life cycle of this parasite, transmission to sea lions, and potential treatment protocols.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: January 21, 2019
2018 journal article
Evaluation of potential serum biomarkers of hepatic fibrosis and necroinflammatory activity in dogs with liver disease
JOURNAL OF VETERINARY INTERNAL MEDICINE, 32(3), 1009–1018.
author keywords: AST; CCL2; CRP; hepatitis; IL-6; MCP-1
MeSH headings : Alanine Transaminase / blood; Animals; Aspartate Aminotransferases / blood; Biomarkers / blood; Biopsy / veterinary; Chemokine CCL2 / blood; Cross-Sectional Studies; Dog Diseases / blood; Dog Diseases / diagnosis; Dogs; Female; Interleukin-6 / blood; Liver / pathology; Liver Cirrhosis / blood; Liver Cirrhosis / diagnosis; Liver Cirrhosis / veterinary; Liver Diseases / blood; Liver Diseases / diagnosis; Liver Diseases / veterinary; Male; Necrosis; Prospective Studies
TL;DR:
Because of substantial variability among dogs, single measurements of IL‐6 and CCL2 have limited diagnostic utility for identifying fibrosis or necroinflammation, respectively, in dogs with various chronic liver diseases.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2018 journal article
MORTALITY IN COQUEREL'S SIFAKAS (PROPITHECUS COQUERELI) UNDER HUMAN CARE: A RETROSPECTIVE SURVEY FROM THE DUKE LEMUR CENTER 1990-2015
JOURNAL OF ZOO AND WILDLIFE MEDICINE, 49(2), 315–323.
author keywords: Coquerel's sifaka; lemur; mortality; Propithecus coquereli; prosimian
MeSH headings : Age Factors; Animals; Animals, Zoo; Endangered Species; Mortality; North Carolina / epidemiology; Retrospective Studies; Strepsirhini
TL;DR:
Insight into common causes of mortality of Coquerel's sifakas (Propithecus coquereli) can be used to guide management of this endangered primate and improve longevity in human care settings
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2018 journal article
New parvovirus associated with serum hepatitis in horses after inoculation of common biological product
Emerging Infectious Diseases, 24(2), 303–310.
Source: NC State University Libraries
Added: August 6, 2018
2018 journal article
Qualitative metabolomics profiling of serum and bile from dogs with gallbladder mucocele formation
PLOS ONE, 13(1).
MeSH headings : Animals; Bile / metabolism; Blood; Dogs; Female; Gallbladder Diseases / blood; Gallbladder Diseases / metabolism; Male; Metabolomics; Mucocele / blood; Mucocele / metabolism
TL;DR:
The findings support the presence of significant metabolic disruption in dogs with mucocele formation and identify specific compounds as candidate biomarkers or treatment targets.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2018 journal article
Viral persistence, liver disease, and host response in a hepatitis C-like virus rat model
Hepatology, 68(2), 435–448.
MeSH headings : Alanine Transaminase; Animals; Antiviral Agents / pharmacology; Disease Models, Animal; Gene Expression Profiling / methods; Hepacivirus / genetics; Hepacivirus / pathogenicity; Hepatitis C / genetics; Hepatitis C / virology; Liver Diseases / virology; MicroRNAs / genetics; RNA, Viral / genetics; Rats; Rats, Sprague-Dawley; Sequence Analysis, DNA / methods; Virus Replication / genetics
TL;DR:
The backbone drug of HCV direct‐acting antiviral therapy, sofosbuvir, effectively suppresses chronic RHV‐rn1 infection in rats, and is developed as a fully immunocompetent and informative surrogate model to delineate the mechanisms ofHCV‐related viral persistence, immunity, and pathogenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Crossref
Added: February 21, 2020
2017 journal article
Interobserver Agreement Using Histological Scoring of the Canine
JOURNAL OF VETERINARY INTERNAL MEDICINE, 31(3), 778–783.
author keywords: Chronic hepatitis; Dog; Hepatic fibrosis; histological scoring
MeSH headings : Animals; Dog Diseases / pathology; Dogs; Fibrosis; Hepatitis, Animal / pathology; Humans; Liver / pathology; Observer Variation; Pathology, Veterinary / standards; Pathology, Veterinary / statistics & numerical data
TL;DR:
There was fair interobserver agreement when pathologists assessed fibrosis and poor agreement when they assessed necroinflammatory activity in dogs and this suboptimal agreement must be taken into account by clinicians making decisions based on histology reports of the liver.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
MYCOBACTERIUM INTRACELLULARE INFECTION CAUSING A RETROPERITONEAL MASS IN A BINTURONG (ARCTICTIS BINTURONG)
JOURNAL OF ZOO AND WILDLIFE MEDICINE, 48(2), 544–548.
Contributors: L. Adamovicz*, S. Kennedy-Stoskopf*, A. Talley*, *, E. Cohen* , P. Bizikova*, V. Grunkemeyer*
author keywords: Arctictis binturong; binturong; mycobacteriosis; Mycobacterium intracellulare; pyogranuloma
MeSH headings : Animals; Male; Mycobacterium avium Complex / isolation & purification; Mycobacterium avium-intracellulare Infection / pathology; Mycobacterium avium-intracellulare Infection / veterinary; Viverridae
TL;DR:
This case represents an unusual presentation of M. intracellulare in a novel species of castrated male binturong with a history of recurrent pyogranulomatous panniculitis, lymphangitis, and dermatitis and acid-fast organisms identified in both the mass and the perineal skin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2017 journal article
Mouse models of acute and chronic hepacivirus infection
SCIENCE, 357(6347), 204-+.
MeSH headings : Animals; CD4-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / immunology; Disease Models, Animal; Hepacivirus / immunology; Hepatitis C / immunology; Hepatitis C, Chronic / immunology; Immunocompetence / immunology; Immunocompromised Host / immunology; Lymphocyte Depletion; Mice; Mice, Inbred C57BL
TL;DR:
It is shown that an HCV-related hepacivirus discovered in Norway rats can establish high-titer hepatotropic infections in laboratory mice with immunological features resembling those seen in human viral hepatitis, which may provide mechanistic insights into hepatic antiviral immunity, a prerequisite for the development of HCV vaccines.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Other viruses: Hepeviridae, hepadnaviridae, deltaviruses, nodaviridae, and unclassified viruses
Fenner's Veterinary Virology, 5th Edition, 547–555.
Source: NC State University Libraries
Added: August 6, 2018
2017 journal article
TIM1 (HAVCR1) Is Not Essential for Cellular Entry of Either Quasi-enveloped or Naked Hepatitis A Virions
MBIO, 8(5).
author keywords: hepatitis A virus; hepatovirus; phosphatidylserine; picornavirus; receptor; viral attachment
MeSH headings : Animals; CRISPR-Cas Systems; Carcinoma, Hepatocellular; Cell Line, Tumor; Chlorocebus aethiops; Hepatitis A / virology; Hepatitis A Virus Cellular Receptor 1 / deficiency; Hepatitis A Virus Cellular Receptor 1 / genetics; Hepatitis A Virus Cellular Receptor 1 / metabolism; Hepatitis A virus / metabolism; Hepatitis A virus / pathogenicity; Hepatitis A virus / physiology; Host-Pathogen Interactions; Humans; Liver / pathology; Liver / physiopathology; Liver / virology; Mice; Receptor, Interferon alpha-beta / deficiency; Receptor, Interferon alpha-beta / genetics; Receptor, Interferon alpha-beta / metabolism; Vero Cells; Virion / metabolism; Virion / pathogenicity; Virion / physiology; Virus Attachment; Virus Internalization; Virus Replication
TL;DR:
It is shown here that TIM1 (HAVCR1) is not an essential cellular receptor for HAV entry into cultured cells or required for viral replication and pathogenesis in permissive strains of mice, although it may facilitate early stages of infection by binding phosphatidylserine on the eHAV surface.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Acute Alpha-Naphthylisothiocyanate-induced Liver Toxicity in Germfree and Conventional Male Rats
TOXICOLOGIC PATHOLOGY, 44(7), 987–997.
author keywords: liver; bile duct; alpha-naphthylisothiocyanate; germfree; rat; toxicity
MeSH headings : 1-Naphthylisothiocyanate / toxicity; Animals; Germ-Free Life / drug effects; Liver / drug effects; Male; Rats; Rats, Sprague-Dawley
TL;DR:
Overall, germfree rats had a modestly greater level of biliary tract injury based on subjective histologic scoring and clinical chemistry measurements following an acute exposure to the well-characterized biliary toxin, ANIT; however, the difference between the ANIT-treated germfree and conventional groups was modest and most evident only within the first day following exposure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
External beam radiation therapy of squamous cell carcinoma in the beak of an African grey parrot (Psittacus timneh)
Journal of Avian Medicine and Surgery, 30(3), 250–256.
MeSH headings : Animals; Beak / pathology; Bird Diseases / radiotherapy; Carcinoma, Squamous Cell / radiotherapy; Carcinoma, Squamous Cell / veterinary; Male; Parrots
TL;DR:
Squamous cell carcinoma of the rhinotheca was diagnosed in a 34-year-old timneh African grey parrot with a 2-year history of beak abnormalities and died approximately 7 months after diagnosis and 4 months after cessation of radiation treatment.
(via Semantic Scholar)
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
2016 journal article
Histiocytic chorioretinitis in a dog
Veterinary Ophthalmology, 21(1), 88–95.
author keywords: canine; chorioretinitis; histiocytic; Melan-A; melanoma; retinal detachment
MeSH headings : Animals; Chorioretinitis / diagnosis; Chorioretinitis / veterinary; Diagnosis, Differential; Diagnostic Techniques, Ophthalmological; Dog Diseases / diagnosis; Dogs; Eye Enucleation; Male
TL;DR:
A 3-year-old castrated male mixed-breed dog presented with an acute bullous retinal detachment and thickened choroid of the right eye, which caused a revision of the histologic diagnosis from melanocytic tumor to histiocytic chorioretinitis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018
2016 journal article
Histology Atlas of the Developing Mouse Hepatobiliary Hemolymphatic Vascular System with Emphasis on Embryonic Days 11.5-18.5 and Early Postnatal Development
TOXICOLOGIC PATHOLOGY, 44(5), 705–725.
author keywords: vascular development; lymphatic development; hepatobiliary development; portal sinus; embryo; mouse; atlas
MeSH headings : Anatomy, Artistic; Animals; Atlases as Topic; Biliary Tract / embryology; Blood Vessels / embryology; Embryo, Mammalian; Embryonic Development; Liver / embryology; Lymphatic System / embryology; Mice; Mice, Transgenic
TL;DR:
This comprehensive histology atlas provides hematoxylin & eosin and immunohistochemical-stained sections of the developing mouse blood and lymphatic vasculature with emphasis on the hepatobiliary system between embryonic days 11.5–18.5 and the early postnatal period.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
MAVS-dependent host species range and pathogenicity of human hepatitis A virus
SCIENCE, 353(6307), 1541–1545.
MeSH headings : Adaptor Proteins, Signal Transducing / genetics; Adaptor Proteins, Signal Transducing / immunology; Animals; Apoptosis; Disease Models, Animal; Hepatitis A / immunology; Hepatitis A / pathology; Hepatitis A / virology; Hepatitis A virus / immunology; Hepatocytes / immunology; Hepatocytes / pathology; Hepatocytes / virology; Host-Pathogen Interactions / immunology; Humans; Interferon Regulatory Factor-3 / genetics; Interferon Regulatory Factor-3 / immunology; Interferon Regulatory Factor-7 / genetics; Interferon Regulatory Factor-7 / immunology; Interferon Type I / immunology; Liver / immunology; Liver / pathology; Liver / virology; Mice; Mice, Knockout; Receptor, Interferon alpha-beta / genetics; Receptor, Interferon alpha-beta / immunology; Receptors, Interferon / genetics; Receptors, Interferon / immunology; Signal Transduction / immunology; Species Specificity
TL;DR:
A murine model of hepatitis A virus (HAV) infection that recapitulates critical features of type A hepatitis in humans is described and it is demonstrated that the capacity of HAV to evade MAVS-mediated type I interferon responses defines its host species range.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Reevaluation and Classification of Duodenal Lesions in B6C3F1 Mice and F344 Rats from 4 Studies of Hexavalent Chromium in Drinking Water
TOXICOLOGIC PATHOLOGY, 44(2), 279–289.
author keywords: mouse pathology; rat pathology; gastrointestinal system; environmental toxicology; cell proliferation; carcinogenesis
MeSH headings : Administration, Oral; Animals; Chromium / toxicity; Drinking Water; Duodenal Neoplasms / chemically induced; Duodenal Neoplasms / epidemiology; Duodenal Neoplasms / pathology; Duodenum / drug effects; Duodenum / pathology; Environmental Exposure; Female; Male; Mice; Mice, Inbred Strains; Rats; Rats, Inbred F344; Toxicity Tests
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2016 article
The Strange, Expanding World of Animal Hepaciviruses
ANNUAL REVIEW OF VIROLOGY, VOL 3, Vol. 3, pp. 53–75.
author keywords: hepatitis C virus; pegivirus; hepegivirus; virome; virus evolution; animal models
MeSH headings : Animals; Cattle / virology; Chiroptera / virology; Colobus / virology; Flavivirus / classification; Flavivirus / genetics; GB virus A / classification; GB virus A / genetics; GB virus C / classification; GB virus C / genetics; Genetic Variation / genetics; Genome, Viral / genetics; Hepacivirus / classification; Hepacivirus / genetics; Hepatitis C / veterinary; Hepatitis C / virology; Horses / virology; Host Specificity; Humans; Pestivirus / classification; Pestivirus / genetics; Sharks / virology
TL;DR:
This review summarizes the significance of these studies and discusses current thinking about the origin and evolution of the animal hepaciviruses as well as their potential usage as surrogate models for the study of hepatitis C virus.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Association of Gallbladder Mucocele Histologic Diagnosis with Selected Drug Use in Dogs: A Matched Case-Control Study
JOURNAL OF VETERINARY INTERNAL MEDICINE, 29(6), 1464–1472.
author keywords: Bile; Canine; Mucus; Xenobiotic
MeSH headings : Animals; Case-Control Studies; Cholinergic Agents / adverse effects; Dog Diseases / chemically induced; Dogs; Female; Gallbladder Diseases / chemically induced; Gallbladder Diseases / veterinary; Hypothyroidism / drug therapy; Imidazoles / adverse effects; Male; Mucocele / chemically induced; Mucocele / pathology; Mucocele / veterinary; Neonicotinoids; Nitro Compounds / adverse effects; Pituitary ACTH Hypersecretion / drug therapy; Pituitary ACTH Hypersecretion / veterinary; Risk Factors; Thyroxine / adverse effects
TL;DR:
This study provides evidence for an association between selected drug use and GBM formation in dogs and exposure to imidacloprid in Shetland sheepdogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2015 journal article
Canine urothelial carcinoma: genomically aberrant and comparatively relevant
Chromosome Research, 23(2), 311–331.
author keywords: Canine; Urothelial carcinoma; Transitional cell carcinoma; Cytogenetics; Chromosome aberration; Array comparative genomic hybridization; Comparative oncology
MeSH headings : Animals; Biopsy; Carcinoma / veterinary; Chromosome Aberrations; Comparative Genomic Hybridization; Computational Biology / methods; DNA Copy Number Variations; Dogs; Female; Genetic Loci; Genomics / methods; Humans; In Situ Hybridization, Fluorescence; Male; Urologic Neoplasms / veterinary
TL;DR:
It is proposed that common aberrations found in primary canine UC biopsies are indicative of an evolutionarily conserved mechanism of pathogenesis and harbor genes key to urothelial neoplasia, warranting investigation for diagnostic, prognostic, and therapeutic applications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, Web Of Science
Added: August 6, 2018
2015 journal article
Clinical, histopathological and immunohistochemical characterization of a novel equine ocular disorder: heterochromic iridocyclitis with secondary keratitis in adult horses
VETERINARY OPHTHALMOLOGY, 18(6), 443–456.
author keywords: endotheliitis; iridocyclitis; keratic precipitates; keratitis; retrocorneal membrane; uveitis
MeSH headings : Animals; Cornea / pathology; Female; Horse Diseases / diagnosis; Horse Diseases / pathology; Horses; Iridocyclitis / diagnosis; Iridocyclitis / pathology; Iridocyclitis / veterinary; Keratitis / diagnosis; Keratitis / pathology; Keratitis / veterinary; Male; Uvea / pathology
TL;DR:
Heterochromic iridocyclitis with secondary keratitis (HIK) is characterized by uveal inflammation with pigment dispersion and suspected corneal endothelial dysfunction and may not respond to therapy and enucleation may ultimately be required to ensure the horse's comfort.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2015 journal article
Effects of azathioprine, 6-mercaptopurine, and 6-thioguanine on canine primary hepatocytes
AMERICAN JOURNAL OF VETERINARY RESEARCH, 76(7), 649–655.
MeSH headings : Animals; Azathioprine / administration & dosage; Azathioprine / pharmacology; Cell Line; Cell Survival / drug effects; Dogs; Dose-Response Relationship, Drug; Hepatocytes / drug effects; Immunosuppressive Agents / administration & dosage; Immunosuppressive Agents / pharmacology; Mercaptopurine / administration & dosage; Mercaptopurine / pharmacology; Thioguanine / administration & dosage; Thioguanine / pharmacology
TL;DR:
Results indicated that thiopurines adversely affected the viability of canine hepatocytes in a time- and concentration-dependent manner but had a nonsignificant effect on the LDH and ALT activities and free glutathione depletion of those hepatocytes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Excess Secretion of Gel-Forming Mucins and Associated Innate Defense Proteins with Defective Mucin Un-Packaging Underpin Gallbladder Mucocele Formation in Dogs
PLOS ONE, 10(9).
MeSH headings : Animals; Dogs; Epithelial Cells / pathology; Epithelial Cells / ultrastructure; Epithelium / pathology; Exocytosis; Gallbladder / diagnostic imaging; Gallbladder / pathology; Gallbladder / surgery; Gallbladder / ultrastructure; Gels / metabolism; Glycosylation; Immunity, Innate; Immunoblotting; Male; Mass Spectrometry; Mucin 5AC / metabolism; Mucin-5B / metabolism; Mucocele / diagnostic imaging; Mucocele / pathology; Mucocele / surgery; Mucous Membrane / pathology; Mucus / metabolism; Phenotype; Rupture; Ultrasonography
TL;DR:
These findings provide an explanation for abnormal mucus behavior and based on similarity to mucus observed in the airways of people with cystic fibrosis, suggest that abnormal mechanisms for maintenance of gallbladder epithelial hydration may be an instigating factor for mucocele formation in dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2014 journal article
Biliary Proliferative Lesions in the Sprague-Dawley Rat: Adverse/Non-adverse
TOXICOLOGIC PATHOLOGY, 42(5), 844–854.
author keywords: rat; biliary; oval cell; adverse; proliferative; bile duct; hyperplasia
MeSH headings : Animals; Bile Duct Neoplasms / pathology; Bile Ducts / cytology; Bile Ducts / metabolism; Bile Ducts / pathology; Biomarkers / metabolism; Cell Proliferation; Female; Hyperplasia / pathology; Male; Rats; Rats, Sprague-Dawley
TL;DR:
Available evidence supports the interpretation that minimal “typical” appearing bile duct hyperplasia limited to the portal triads may be considered non-adverse in the rat and is of little to no concern to humans.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 personal communication
Effects of excess dietary fructose on liver pathology study have significant methodologic limitations: Reply
Source: NC State University Libraries
Added: August 6, 2018
2014 journal article
Evaluation of fluorescence in situ hybridization for the detection of bacteria in feline inflammatory liver disease
JOURNAL OF FELINE MEDICINE AND SURGERY, 16(2), 109–117.
MeSH headings : Animals; Bacteria / isolation & purification; Case-Control Studies; Cat Diseases / diagnosis; Cat Diseases / microbiology; Cats; Female; In Situ Hybridization, Fluorescence / methods; In Situ Hybridization, Fluorescence / veterinary; Inflammation / microbiology; Inflammation / veterinary; Liver / microbiology; Liver / pathology; Liver Diseases / microbiology; Liver Diseases / veterinary; Male; Retrospective Studies
TL;DR:
The distribution of bacteria within the liver supports the possibility of colonization via either enteric translocation or hematogenous seeding and suggests a role in etiopathogenesis of feline inflammatory liver disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Hyperinsulinemic Hypoglycemia Syndrome in 2 Dogs with Bartonellosis
Journal of Veterinary Internal Medicine, 28(4), 1331–1335.
author keywords: Dog; Hyperinsulinemia; Hypoglycemia; Monocytosis; Seizures
MeSH headings : Animals; Bartonella Infections / complications; Bartonella Infections / veterinary; Dog Diseases / microbiology; Dog Diseases / physiopathology; Dogs; Hyperinsulinism / etiology; Hyperinsulinism / veterinary; Hypoglycemia / etiology; Hypoglycemia / veterinary; Male; Syndrome
TL;DR:
A 6-month-old male castrated, 21-kg Weimaraner developed seizures after surgical castration and umbilical hernia repair and was referred to NCSU-CVM-VTH for further evaluation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2014 journal article
Lack of association of ABCB4 insertion mutation with gallbladder mucoceles in dogs
JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, 26(3), 434–436.
author keywords: ABCB4 gene; canine; gall bladder; mucocele
TL;DR:
The current study did not identify a strong association between ABCB4 1583_1584G and GBM in Shetland Sheepdogs or other breeds.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Liver biomarker and in vitro assessment confirm the hepatic origin of aminotransferase elevations lacking histopathological correlate in beagle dogs treated with GABA(A) receptor antagonist NP260
TOXICOLOGY AND APPLIED PHARMACOLOGY, 277(2), 131–137.
author keywords: Canine; Biomarker; Hepatotoxicity; Liver; Hepatic; miRNA; miR-122; GLDH; SDH
MeSH headings : Adenosine Triphosphate / metabolism; Alanine Transaminase / blood; Animals; Biomarkers / blood; Cells, Cultured; Chemical and Drug Induced Liver Injury / blood; Chemical and Drug Induced Liver Injury / diagnosis; Chemical and Drug Induced Liver Injury / etiology; Chemical and Drug Induced Liver Injury / genetics; Clinical Enzyme Tests; Dogs; Female; GABA-A Receptor Antagonists / toxicity; Genetic Markers; Glutamate Dehydrogenase / blood; Hepatocytes / drug effects; Hepatocytes / enzymology; Hepatocytes / pathology; Humans; L-Iditol 2-Dehydrogenase / blood; Liver / drug effects; Liver / enzymology; Liver / pathology; Male; MicroRNAs / blood; Necrosis; Predictive Value of Tests; Rats; Rats, Sprague-Dawley; Risk Assessment; Species Specificity; Sulfones / toxicity; Time Factors; Toxicity Tests / methods; meta-Aminobenzoates / toxicity
TL;DR:
The data indicate that a diagnostic biomarker approach, coupled with sensitive in vitro screening strategies, may facilitate interpretation of toxicity potential when an adaptive event masks the underlying toxicity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Role of Pregnane X Receptor in Obesity and Glucose Homeostasis in Male Mice
JOURNAL OF BIOLOGICAL CHEMISTRY, 289(6), 3244–3261.
author keywords: Diabetes; Metabolic Syndrome; Nuclear Receptors; Obesity; Peroxisome Proliferator-activated Receptor (PPAR)
MeSH headings : Adipose Tissue / metabolism; Adipose Tissue / pathology; Animals; Carnitine O-Palmitoyltransferase / genetics; Carnitine O-Palmitoyltransferase / metabolism; Diabetes Mellitus, Type 2 / genetics; Diabetes Mellitus, Type 2 / metabolism; Diabetes Mellitus, Type 2 / pathology; Female; Glucokinase / genetics; Glucokinase / metabolism; Glucose / genetics; Glucose / metabolism; Hepatomegaly / genetics; Hepatomegaly / metabolism; Hepatomegaly / pathology; Humans; Hyperinsulinism / genetics; Hyperinsulinism / metabolism; Hyperinsulinism / pathology; Liver / metabolism; Liver / pathology; Male; Mice; Mice, Knockout; Obesity / genetics; Obesity / metabolism; Obesity / pathology; PPAR alpha / genetics; PPAR alpha / metabolism; Pregnane X Receptor; Receptors, Steroid / genetics; Receptors, Steroid / metabolism; Species Specificity
TL;DR:
Although the mouse PXR promotes HFD-induced obesity, the hPXR mouse carries a genetic predisposition for type 2 diabetes and thus provides a model for exploring the role of human PxR in the metabolic syndrome.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Role of human pregnane X receptor in high fat diet-induced obesity in pre-menopausal female mice
BIOCHEMICAL PHARMACOLOGY, 89(3), 399–412.
author keywords: Obesity; High-fat diet; Pregnane X receptor; Nuclear receptors; Type 2 diabetes; Females
MeSH headings : Adipose Tissue, White; Animals; Blood Glucose; Cytochrome P-450 CYP3A / genetics; Cytochrome P-450 CYP3A / metabolism; Dietary Fats / adverse effects; Female; Gene Expression Regulation; Glucose Intolerance; Humans; Ion Channels / genetics; Ion Channels / metabolism; Liver; Male; Membrane Proteins / genetics; Membrane Proteins / metabolism; Mice; Mice, Transgenic; Mitochondrial Proteins / genetics; Mitochondrial Proteins / metabolism; Obesity / drug therapy; Obesity / etiology; Pregnane X Receptor; Receptors, Steroid / genetics; Receptors, Steroid / metabolism; Uncoupling Protein 1
TL;DR:
The studies indicate that the hPXR gene promotes obesity and metabolic syndrome by dysregulating lipid and glucose homeostasis while inhibiting UCP1 expression and indicates that the human PXR suppresses the protective role of estrogen in metabolic disorders.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Thymofibrolipoma in a Labrador Retriever
VETERINARY PATHOLOGY, 51(4), 816–819.
author keywords: dog; immunohistochemistry; thymoma; thymus gland
MeSH headings : Animals; Collagen / metabolism; Dog Diseases / pathology; Dog Diseases / surgery; Dogs; Epithelial Cells / pathology; Immunohistochemistry / veterinary; Lipoma / pathology; Lipoma / surgery; Lipoma / veterinary; Male; Neoplasms, Fibroepithelial / pathology; Neoplasms, Fibroepithelial / surgery; Neoplasms, Fibroepithelial / veterinary; North Carolina; Thymus Neoplasms / pathology; Thymus Neoplasms / surgery; Thymus Neoplasms / veterinary; Tomography, X-Ray Computed / veterinary
TL;DR:
A cranial thoracic mass was identified in a 6-year-old Labrador Retriever that was characterized by robust collagenous stroma dissected by thin cords of cytokeratin-positive neoplastic epithel cells and bordered by mildly pleomorphic epithelial cells with occasional lymphocytic aggregates and rare Hassall corpuscles.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Visualizing surface area and volume of lumens in three dimensions using images from histological sections
JOURNAL OF MICROSCOPY, 256(3), 190–196.
author keywords: 3-D reconstruction; histology; liver; negative space; portal tract
MeSH headings : Animals; Bile Ducts / cytology; Blood Vessels / cytology; Dogs; Imaging, Three-Dimensional / methods; Liver / cytology; Microscopy, Polarization / methods; Xylem / cytology
TL;DR:
Significant differences between vessels and ducts across lobes and gender in control samples are discussed and differences were also found between control and mixed breed dogs and between controls and a dog that died of accidental traumatic haemorrhage.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Cardiac structure and function in female carrier's of a canine model of Duchenne muscular dystrophy
RESEARCH IN VETERINARY SCIENCE, 94(3), 610–617.
author keywords: Cardiomyopathy; Carrier; GRMD; Duchenne muscular dystrophy
MeSH headings : Animals; Disease Models, Animal; Dog Diseases / genetics; Dog Diseases / pathology; Dog Diseases / physiopathology; Dogs; Echocardiography / veterinary; Electrocardiography / veterinary; Electrocardiography, Ambulatory / veterinary; Female; Heart / physiopathology; Heterozygote; Muscular Dystrophy, Animal / genetics; Muscular Dystrophy, Animal / pathology; Muscular Dystrophy, Animal / physiopathology; Myocardium / pathology
TL;DR:
Despite cardiac mosaic dystrophin expression and degenerative cardiac lesions, GRMD carriers at up to 3 years of age could not be distinguished statistically from normal controls by echocardiography or 24-h Holter monitoring.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2013 journal article
Chikungunya Virus Host Range E2 Transmembrane Deletion Mutants Induce Protective Immunity against Challenge in C57BL/6J Mice
JOURNAL OF VIROLOGY, 87(12), 6748–6757.
MeSH headings : Alphavirus Infections / immunology; Alphavirus Infections / prevention & control; Alphavirus Infections / virology; Animals; Antibodies, Neutralizing / blood; Antibodies, Viral / blood; Cell Line; Chikungunya Fever; Chikungunya virus / genetics; Chikungunya virus / immunology; Chikungunya virus / pathogenicity; Chikungunya virus / physiology; Host Specificity; Humans; Mice; Mice, Inbred C57BL; Mutation; Sequence Deletion; Vaccines, Attenuated / genetics; Vaccines, Attenuated / immunology; Viral Vaccines / genetics; Viral Vaccines / immunology; Virus Replication
TL;DR:
This study identified a ChikV HR mutant that grows to high levels in insect cells but was restricted in the ability to assemble virus in mammalian cells in vitro.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Dietary fructose induces endotoxemia and hepatic injury in calorically controlled primates
AMERICAN JOURNAL OF CLINICAL NUTRITION, 98(2), 349–357.
MeSH headings : Animal Feed / analysis; Animals; Diet, Fat-Restricted; Endotoxemia / chemically induced; Endotoxemia / pathology; Endpoint Determination; Energy Intake; Fatty Liver / chemically induced; Fatty Liver / pathology; Female; Fructose / adverse effects; Haplorhini; Liver / drug effects; Liver / microbiology; Liver / pathology; Male; Metagenome; Obesity / pathology; Weight Gain / drug effects
TL;DR:
Even in the absence of weight gain, fructose rapidly causes liver damage that is secondary to endotoxemia and MT, and data support fructose inducing both MT and ectopic fat deposition in primates.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2013 personal communication
From Bipeds to an Honorary Member of the American College of Veterinary Pathologists
Meuten, D. J., Law, J. M., Stromberg, P. C., & Cullen, J. M. (2013, May).
MeSH headings : Animals; Autopsy; Communication; Humans; Pathology, Veterinary / methods; Terminology as Topic
TL;DR:
If the word autopsy is more acceptable to pet owners than necropsy, then it is hoped all clinicians will use this term, written and verbally, as they explain how further examination of their pet is essential to help other pets and researchers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Granulomatous metritis caused by suspected Dirofilaria immitis in a dog: a case report
VETERINARNI MEDICINA, 58(8), 437–441.
author keywords: dog; filarid; granuloma; larva; nematode; uterus
TL;DR:
A unique uterine mass in a dog with granulomatous lesions caused by filarial larvae from the family Onchocercidae is described and these nematodes were tentatively identified as Dirofilaria immitis larvae.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Necrolytic migratory erythema associated with a glucagon-producing primary hepatic neuroendocrine carcinoma in a cat
VETERINARY DERMATOLOGY, 24(4), 466–E110.
MeSH headings : Animals; Carcinoma, Neuroendocrine / complications; Carcinoma, Neuroendocrine / pathology; Carcinoma, Neuroendocrine / veterinary; Cat Diseases / etiology; Cat Diseases / pathology; Cats; Glucagon / metabolism; Liver Neoplasms / complications; Liver Neoplasms / pathology; Liver Neoplasms / veterinary; Male; Necrolytic Migratory Erythema / etiology; Necrolytic Migratory Erythema / pathology; Necrolytic Migratory Erythema / veterinary
TL;DR:
This is the first case report of NME associated with a glucagon-producing primary hepatic neuroendocrine carcinoma in a cat and it was euthanized 11 months after the initial presentation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2013 personal communication
Primate fructose study misses mark due to preventable design flaws Reply
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
Cutting Through to the Truth: Laser Capture Microscopy and Acute Toxic Biliary Injury
Journal of Comparative Pathology, 146(1), 45.
Source: Crossref
Added: December 29, 2020
2012 journal article
Evaluation of diode endoscopic cyclophotocoagulation in bovine cadaver eyes
AMERICAN JOURNAL OF VETERINARY RESEARCH, 73(9), 1445–1452.
MeSH headings : Animals; Cadaver; Cattle; Cattle Diseases / pathology; Cattle Diseases / surgery; Endoscopy / methods; Endoscopy / veterinary; Glaucoma / pathology; Glaucoma / surgery; Glaucoma / veterinary; Histocytochemistry; Laser Coagulation / instrumentation; Laser Coagulation / methods; Laser Coagulation / veterinary
TL;DR:
Evaluating the anterior chamber approach and energy levels for endoscopic cyclophotocoagulation (ECPC) and assessing ECPC-induced tissue damage in phakic eyes of bovine cadavers found the 0.75- and 0.90-J energy levels had the potential to effectively treat the ciliary epithelium.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2012 journal article
Limited yield of diagnoses of intrahepatic infectious causes of canine granulomatous hepatitis from archival liver tissue
Journal of Veterinary Diagnostic Investigation, 24(5), 888–894.
author keywords: Copper hepatopathy; dogs; fluorescent in situ hybridization; granulomatous hepatitis; polymerase chain reaction
MeSH headings : Animals; Bartonella / isolation & purification; Bartonella Infections / diagnosis; Bartonella Infections / microbiology; Bartonella Infections / pathology; Bartonella Infections / veterinary; Dog Diseases / diagnosis; Dog Diseases / pathology; Dogs; Female; Formaldehyde; Granuloma / pathology; Granuloma / veterinary; Hepatitis, Animal / diagnosis; Hepatitis, Animal / pathology; Liver / pathology; Male; Paraffin Embedding; Retrospective Studies; Tissue Preservation / veterinary
TL;DR:
It was concluded that investigation of infectious etiologies within FFPE liver specimens using these diagnostic approaches may be of low yield.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2012 journal article
Reye's or Reye's-like syndrome in western lowland gorilla (Gorilla gorilla gorilla)
JOURNAL OF MEDICAL PRIMATOLOGY, 41(5), 329–331.
author keywords: encephalopathy; Gorilla gorilla gorilla; hepatopathy; Reye's syndrome; western lowland gorilla
MeSH headings : Animals; Ape Diseases / blood; Ape Diseases / pathology; Fatal Outcome; Female; Gorilla gorilla; Kidney / pathology; Liver / pathology; Reye Syndrome / blood; Reye Syndrome / pathology; Reye Syndrome / veterinary
TL;DR:
A 15‐year‐old western lowland gorilla (Gorilla gorilla gorilla) died shortly after transfer to the North Carolina Zoo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Serology-Enabled Discovery of Genetically Diverse Hepaciviruses in a New Host
JOURNAL OF VIROLOGY, 86(11), 6171–6178.
MeSH headings : 5' Untranslated Regions; Animals; Antigens, Viral / genetics; Hepacivirus / genetics; Hepacivirus / immunology; Hepacivirus / pathogenicity; Hepatitis C / immunology; Hepatitis C / veterinary; Hepatitis C Antibodies / blood; Horse Diseases / virology; Horses; Host Specificity; Molecular Sequence Data; Nucleic Acid Conformation; RNA, Viral / genetics; Recombinant Proteins / genetics; Sequence Analysis, DNA
TL;DR:
A versatile serology-based approach is used to determine the natural host of the only known nonprimate hepacivirus (NPHV), CHV, which is also the closest phylogenetic relative of HCV, and suggest a promising new nonPRimate animal model.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Development of an Animal Model for Radiofrequency Ablation of Primary, Virally Induced Hepatocellular Carcinoma in the Woodchuck
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 22(11), 1613–1618.
MeSH headings : Animals; Biopsy; Carcinoma, Hepatocellular / pathology; Carcinoma, Hepatocellular / surgery; Carcinoma, Hepatocellular / virology; Catheter Ablation / instrumentation; Contrast Media; Equipment Design; Hepatitis B / complications; Hepatitis B / virology; Hepatitis B Virus, Woodchuck / pathogenicity; Liver Neoplasms, Experimental / pathology; Liver Neoplasms, Experimental / surgery; Liver Neoplasms, Experimental / virology; Magnetic Resonance Imaging; Marmota; Necrosis; Reproducibility of Results; Time Factors
TL;DR:
A safe, reliable and consistent method was developed to study RF ablation of spontaneous primary HCC using chronically WHV-infected woodchucks, an animal model of hepatitis B virus-induced HCC.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
H-ras Consensus Sequence and Mutations in Primary Hepatocellular Carcinomas of Lemurs and Lorises
VETERINARY PATHOLOGY, 48(4), 868–874.
author keywords: liver; molecular biology; oncology; primate; zoo; hepatocellular carcinoma
MeSH headings : Animals; Carcinoma, Hepatocellular / genetics; Carcinoma, Hepatocellular / pathology; Carcinoma, Hepatocellular / veterinary; Consensus Sequence; Female; Gene Expression Regulation, Neoplastic; Genes, ras / genetics; Lemur; Liver Neoplasms / genetics; Liver Neoplasms / pathology; Liver Neoplasms / veterinary; Lorisidae; Male; Mutation; Primate Diseases / genetics; Primate Diseases / pathology
TL;DR:
The authors have determined a consensus sequence for exons 1 and 2 of H-ras from captive lemurs and lorises and evaluated samples of nonneoplastic liver and hepatocellular carcinomas from affected animals for mutations in these exons, and have determined that it is identical to that of human H-ra and differs only slightly from the chimpanzee sequence.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Molecular cytogenetic characterization of canine histiocytic sarcoma: A spontaneous model for human histiocytic cancer identifies deletion of tumor suppressor genes and highlights influence of genetic background on tumor behavior
BMC Cancer, 11.
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
Necropsy or Autopsy? It’s All About Communication!
Veterinary Pathology, 49(2), 271–272.
MeSH headings : Animals; Autopsy; Communication; Humans; Pathology, Veterinary / methods; Terminology as Topic
TL;DR:
Several of us have decided that communication is more important than tradition and postmortem examination of nonhumans was proscribed from using the term and was designated ‘‘necropsy’.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref
Added: August 6, 2018
2011 journal article
Recommended guidelines for submission, trimming, margin evaluation, and reporting of tumor biopsy specimens in veterinary surgical pathology
Veterinary Pathology, 48(1), 19–31.
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
Recommended guidelines for the conduct and evaluation of prognostic studies in veterinary oncology
Veterinary Pathology, 48(1), 7–18.
Source: NC State University Libraries
Added: August 6, 2018
2010 journal article
Acute ANIT Toxicity in Male IL-10 Knockout and Wild-type Mice
TOXICOLOGIC PATHOLOGY, 38(5), 745–755.
author keywords: animal models; toxicologic pathology; hepatobiliary system; histopathology; knockout mouse; liver; mouse pathology
MeSH headings : Animals; Chemical and Drug Induced Liver Injury / genetics; Chemical and Drug Induced Liver Injury / metabolism; Chemical and Drug Induced Liver Injury / pathology; Gallbladder / drug effects; Gallbladder / pathology; Immunohistochemistry; Interleukin-10 / genetics; Isothiocyanates / toxicity; Male; Mice; Mice, Inbred C57BL; Mice, Knockout
TL;DR:
It is suggested that IL-10 KO mice have less hepatocellular injury than WT mice following a toxic dose of ANIT and that biliary epithelial injury is accentuated in the KO mice.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Congenital Hepatic Fibrosis in 5 Dogs
VETERINARY PATHOLOGY, 47(1), 102–107.
author keywords: bile ducts; biliary tract diseases; canine; embryonic development; liver
MeSH headings : Animals; Bile Ducts / pathology; Dog Diseases / congenital; Dog Diseases / pathology; Dogs; Female; Liver / pathology; Liver Cirrhosis / congenital; Liver Cirrhosis / pathology; Liver Cirrhosis / veterinary; Male; Proliferating Cell Nuclear Antigen / metabolism
TL;DR:
Congenital hepatic fibrosis should be considered in the differential diagnosis in young dogs that present with portal hypertension and lesions that may have been interpreted as bridging biliary hyperplasia or extrahepatic biliary obstruction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Imaging diagnosis-neuronal ceroid lipofuscinosis with a chronic subdural hematoma
Veterinary Radiology & Ultrasound, 51(2), 155–158.
Source: NC State University Libraries
Added: August 6, 2018
2010 journal article
Spontaneous Hepatocellular Carcinoma in Captive Prosimians
VETERINARY PATHOLOGY, 47(2), 306–311.
author keywords: Hepadnaviridae; hepatocellular carcinoma; iron; lemur; liver cell adenoma; neoplasms; prosimians
MeSH headings : Animals; Carcinoma, Hepatocellular / epidemiology; Carcinoma, Hepatocellular / pathology; Carcinoma, Hepatocellular / veterinary; Female; Histocytochemistry / veterinary; Incidence; Lemur; Liver Neoplasms / epidemiology; Liver Neoplasms / pathology; Liver Neoplasms / veterinary; Male; Monkey Diseases / epidemiology; Monkey Diseases / pathology; Retrospective Studies
TL;DR:
Hepatocellular neoplasia is relatively common in captive prosimians, although previously suspected etiologies seem unlikely.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Time Course Gene Expression Using Laser Capture Microscopy-Extracted Bile Ducts, but Not Hepatic Parenchyma, Reveals Acute Alpha-Naphthylisothiocyanate Toxicity
TOXICOLOGIC PATHOLOGY, 38(5), 715–729.
author keywords: bioinformatics; apoptosis/cell death; biotechnology; genomics; hepatobiliary system; histopathology; toxicity
MeSH headings : 1-Naphthylisothiocyanate / toxicity; Animals; Bile Ducts / drug effects; Gene Expression / drug effects; Gene Expression Profiling; Liver / drug effects; Male; Microscopy, Confocal; Oligonucleotide Array Sequence Analysis; Rats; Rats, Sprague-Dawley; Time; Unfolded Protein Response / drug effects
TL;DR:
Specific biliary epithelial gene expression changes, indicative of a vigorous unfolded protein response with protein destruction and cell death pathway activation were noted, in contrast to minor changes in the hepatic parenchyma within 6 hours following oral exposure to ANIT.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
ACQUIRED ARTERIOVENOUS FISTULA IN A GRIZZLY BEAR (URSUS ARCTOS HORRIBILIS)
JOURNAL OF ZOO AND WILDLIFE MEDICINE, 40(1), 193–195.
author keywords: Acquired arteriovenous fistula; grizzly bear; Ursus arctos horribilis; trauma; wound
MeSH headings : Animals; Arteriovenous Fistula / diagnosis; Arteriovenous Fistula / surgery; Arteriovenous Fistula / veterinary; Male; Treatment Outcome; Ursidae; Wounds and Injuries / complications; Wounds and Injuries / veterinary
TL;DR:
Arteriovenous fistulas can develop after traumatic injury and should be considered as a potential complication in bears with nonhealing wounds.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Aflatoxin B1 and/or Hepatitis B Virus Induced Tumor Spectrum in a Genetically Engineered Hepatitis B Virus Expression and Trp53 Haploinsufficient Mouse Model System for Hepatocarcinogenesis
TOXICOLOGIC PATHOLOGY, 37(3), 333–342.
author keywords: aflatoxin B-1; hepatitis B virus; hepatocellular carcinoma; p53; transgenic; Trp53; tumorigenesis; FVB/N strain
MeSH headings : Aflatoxin B1 / genetics; Animals; Disease Models, Animal; Female; Genetic Engineering / adverse effects; Hepatitis B Surface Antigens / genetics; Hepatitis B virus / genetics; Immunohistochemistry; Kaplan-Meier Estimate; Ki-67 Antigen / genetics; Liver Neoplasms, Experimental / chemically induced; Liver Neoplasms, Experimental / genetics; Liver Neoplasms, Experimental / pathology; Liver Neoplasms, Experimental / virology; Male; Mice; Mice, Inbred Strains; Mice, Transgenic; Sex Factors; Survival Analysis; Tumor Suppressor Protein p53 / genetics
TL;DR:
In this model system, HBV expression affected only hepatocellular neoplasia in association with both aflatoxin B1 initiation and p53 haploinsufficiency, and the HBV transgene increased the risk of sarcoma in males and females.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Microarray-based cytogenetic profiling reveals recurrent and subtype-associated genomic copy number aberrations in feline sarcomas
CHROMOSOME RESEARCH, 17(8), 987–1000.
author keywords: microarray; comparative genomic hybridization (CGH); feline; sarcoma; chromosome
MeSH headings : Animals; Cat Diseases / diagnosis; Cats; Cytogenetic Analysis; DNA Copy Number Variations; Gene Dosage; Gene Expression Profiling; Injections / adverse effects; Oligonucleotide Array Sequence Analysis; Sarcoma / diagnosis; Sarcoma / genetics; Sarcoma / veterinary
TL;DR:
Construction of a genomic microarray platform for detection of recurrent CNAs in feline tumors through cytogenetic assignment of 210 large-insert DNA clones selected at intervals of ∼15 Mb from the feline genome sequence assembly is reported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Summary of the World Small Animal Veterinary Association Standardization Committee Guide to Classification of Liver Disease in Dogs and Cats
VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE, 39(3), 395-+.
author keywords: Pathology; Histopathology; Liver; Classification; Dog; Cat
MeSH headings : Animals; Cat Diseases / classification; Cat Diseases / microbiology; Cat Diseases / pathology; Cats; Dog Diseases / classification; Dog Diseases / microbiology; Dog Diseases / pathology; Dogs; Interprofessional Relations; Liver Diseases / classification; Liver Diseases / microbiology; Liver Diseases / pathology; Liver Diseases / veterinary; Societies; Terminology as Topic
TL;DR:
The World Small Animal Veterinary Association has formed a group of experienced clinicians and pathologists to develop a standardized format for diagnostic terminology to find a sound scientific basis of diagnostic and treatment protocols for hepatobiliary diseases.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Expression of CDK4 or CDK2 in mouse oral cavity is retained in adult pituitary with distinct effects on tumorigenesis
CANCER RESEARCH, 68(1), 162–171.
MeSH headings : Animals; Cell Count; Cell Transformation, Neoplastic / genetics; Cell Transformation, Neoplastic / metabolism; Cyclin-Dependent Kinase 2 / analysis; Cyclin-Dependent Kinase 2 / genetics; Cyclin-Dependent Kinase 2 / metabolism; Cyclin-Dependent Kinase 4 / analysis; Cyclin-Dependent Kinase 4 / genetics; Cyclin-Dependent Kinase 4 / metabolism; Cyclin-Dependent Kinase Inhibitor p27 / genetics; Cyclin-Dependent Kinase Inhibitor p27 / metabolism; Humans; Mice; Mice, Transgenic; Mouth / embryology; Mouth / enzymology; Pituitary Gland / enzymology; Pituitary Neoplasms / enzymology; Pituitary Neoplasms / genetics; Promoter Regions, Genetic; Stem Cells
TL;DR:
It is shown that deregulation of CDK expression in the primitive oral epithelium plays a unique function, providing a selective advantage that gives rise to transgene-positive TA-like pituitary cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Harderian gland neoplasms in captive, wild-caught Beechey ground squirrels (Spermophilus beecheyi)
VETERINARY PATHOLOGY, 45(3), 388–392.
author keywords: carcinoma; ground squirrel hepatitis virus; ground squirrels; Harderian gland; Sciuridae
MeSH headings : Adenocarcinoma / pathology; Adenocarcinoma / veterinary; Animals; Animals, Wild; Eye Neoplasms / pathology; Eye Neoplasms / veterinary; Female; Functional Laterality; Harderian Gland / pathology; Male; Neoplasms / pathology; Neoplasms / veterinary; Sciuridae
TL;DR:
Harderian gland neoplasms were identified in 18 aged, adult Beechey ground squirrels (Spermophilus beecheyi) from the records of 167 wild-caught captive animals that were necropsied, the first detailed report of Harderian glands neoplasia in wild Sciuridae.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Serologic survey of woodchuck hepatitis virus in North Carolina woodchucks (Marmota monax)
JOURNAL OF ZOO AND WILDLIFE MEDICINE, 39(2), 263–265.
author keywords: hepadnavirus; woodchuck; woodchuck hepatitis virus
MeSH headings : Animals; Antibodies, Viral / blood; Female; Hepatitis Viruses / immunology; Hepatitis, Viral, Animal / epidemiology; Male; Marmota / virology; Rodent Diseases / epidemiology; Seroepidemiologic Studies; United States / epidemiology
TL;DR:
Data indicate that WHV is present in central North Carolina at rates approaching those seen in endemic areas, such as the mid-Atlantic region of the United States.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2007 journal article
Selective deletion of antigen-specific CD8(+) T cells by MHC class I tetramers, coupled to the type I ribosome-inactivating protein saporin
BLOOD, 109(8), 3300–3307.
MeSH headings : Animals; Autoimmune Diseases / drug therapy; Autoimmune Diseases / immunology; Autoimmune Diseases / pathology; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / pathology; Cell Death / drug effects; Clonal Deletion / drug effects; Cytotoxins / immunology; Cytotoxins / pharmacology; Histocompatibility Antigens Class I / immunology; Histocompatibility Antigens Class I / pharmacology; Mice; Mice, Transgenic; N-Glycosyl Hydrolases / pharmacology; Plant Proteins / pharmacology; Ribosome Inactivating Proteins, Type 1; Saporins; Time Factors; Transplantation, Homologous
TL;DR:
This work demonstrates the therapeutic potential of cytotoxic tetramers to selectively eradicate pathogenic clonotypes while leaving overall T-cell immunity intact.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2007 journal article
The liver of woodchucks chronically infected with the woodchuck hepatitis virus contains foci of virus core antigen-negative hepatocytes with both altered and normal morphology
VIROLOGY, 359(2), 283–294.
author keywords: foci of altered hepatocytes; Woodchuck hepatitis virus; WHV; hepatocellular carcinoma
MeSH headings : Animals; Cell Line, Tumor; Fetuin-B; Gene Expression Regulation, Viral; Hepatitis B Core Antigens / metabolism; Hepatitis B Virus, Woodchuck / physiology; Hepatitis B, Chronic / pathology; Hepatitis B, Chronic / virology; Hepatocytes / cytology; Hepatocytes / pathology; Hepatocytes / virology; Humans; Marmota / virology; RNA, Messenger / genetics; RNA, Messenger / metabolism; alpha-Fetoproteins / metabolism
TL;DR:
It is hypothesized that a common event is loss of the ability to express WHV, allowing these hepatocytes to escape immune mediated cell death and to undergo clonal expansion to form distinct foci.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2006 article
Fall panicum (Panicum dichotomiflorum) hepatotoxicosis in horses and sheep
JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 20, pp. 1414–1421.
author keywords: apoptosis; hepatocyte necrosis; liver; steroidal saponins
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
P.050 Appearance of core antigen negative hepatocytes in woodchucks chronically infected with woodchuck hepatitis virus
Journal of Clinical Virology, 36, S76.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2006 review
The role of pathology in the identification of drug-induced hepatic toxicity
[Review of ]. EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 2(2), 241–247.
author keywords: drug-induced toxicity; liver; pathology; safety assessment; toxicology
MeSH headings : Animals; Chemical and Drug Induced Liver Injury / diagnosis; Chemical and Drug Induced Liver Injury / etiology; Drug Evaluation, Preclinical / methods; Drug Industry / methods; Humans; Liver / pathology; Pathology, Clinical / education; Pathology, Clinical / methods
TL;DR:
Technological advances require pathologists to integrate molecular-based mechanistic data effectively with traditional morphological evaluation to develop a more detailed grasp of the pathogenesis of drug-induced injury.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
CDNA microarray analysis of HBV transgenic mouse liver identifies genes in lipid biosynthetic and growth control pathways affected by HBV
JOURNAL OF MEDICAL VIROLOGY, 77(1), 57–65.
author keywords: gene expression; molecular virology; host-pathogen interaction
MeSH headings : Animals; DNA, Complementary / analysis; Disease Models, Animal; Hepatitis B / genetics; Hepatitis B / immunology; Hepatitis B / virology; Hepatitis B virus / genetics; Hepatitis B virus / immunology; Hepatitis B virus / pathogenicity; Hepatitis B virus / physiology; Lipids / biosynthesis; Liver / metabolism; Liver / virology; Mice; Mice, Transgenic; Oligonucleotide Array Sequence Analysis
TL;DR:
These data are the first to specifically identify enzymes involved in fatty acid and NADPH‐electron transport pathways that are altered by the presence of HBV, and demonstrates that HBV is well adapted to non‐cytopathic replication in hepatoctyes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Mechanistic Classification of Liver Injury
Toxicologic Pathology, 33(1), 6–8.
author keywords: liver toxicity hepatocyte; cholestasis; apoptosis; autoimmunity; mitochondrial toxicity; cytochrome p450
MeSH headings : Acetaminophen / adverse effects; Analgesics, Non-Narcotic / adverse effects; Animals; Apoptosis / drug effects; Autoimmunity / drug effects; Calcium / metabolism; Chemical and Drug Induced Liver Injury, Chronic / classification; Chemical and Drug Induced Liver Injury, Chronic / metabolism; Chemical and Drug Induced Liver Injury, Chronic / pathology; Cytochrome P-450 Enzyme System / drug effects; Hepatocytes / drug effects; Hepatocytes / pathology; Humans; Liver Diseases / classification; Liver Diseases / metabolism; Liver Diseases / pathology; Mitochondria / drug effects
TL;DR:
A classification of liver injury is presented as a means to better understand the spectrum of known mechanisms of Liver injury and to assist in discovering novel pathways of toxic liver injury.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: August 6, 2018
2005 journal article
Paraneoplastic pemphigus in a dog with splenic sarcoma
VETERINARY PATHOLOGY, 42(1), 88–91.
author keywords: autoantibodies; autoimmunity; blistering skin disease; canine; erythema multiforme; immunoblotting; immunofluorescence; immunoprecipitation; neoplasia; pemphigus; skin; spleen
MeSH headings : Animals; Autoantibodies / blood; Dog Diseases / pathology; Dogs; Fatal Outcome; Histocytochemistry / veterinary; Immunoprecipitation / veterinary; Male; Pemphigus / complications; Pemphigus / pathology; Pemphigus / veterinary; Sarcoma / complications; Sarcoma / pathology; Sarcoma / surgery; Sarcoma / veterinary; Splenectomy / veterinary; Splenic Neoplasms / complications; Splenic Neoplasms / pathology; Splenic Neoplasms / surgery; Splenic Neoplasms / veterinary
TL;DR:
Clinical, histopathologic, and immunologic findings in this patient were similar to those observed in human patients with PNP, and the splenic neoplasia in this dog was diagnosed as a phenotypically variable spindle cell sarcoma.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2004 journal article
Adenovirus-based gene therapy during clevudine treatment of woodchucks chronically infected with woodchuck hepatitis virus
VIROLOGY, 327(1), 26–40.
author keywords: hepatitis B virus; clevudine; IFN-alpha
MeSH headings : Adenoviridae / genetics; Adenoviridae / pathogenicity; Animals; Antiviral Agents / administration & dosage; Antiviral Agents / therapeutic use; Arabinofuranosyluracil / administration & dosage; Arabinofuranosyluracil / analogs & derivatives; Arabinofuranosyluracil / therapeutic use; Baculoviridae / genetics; Baculoviridae / metabolism; Cell Line; Combined Modality Therapy; Genetic Therapy; Hepatitis B Virus, Woodchuck / drug effects; Hepatitis B Virus, Woodchuck / genetics; Hepatitis B Virus, Woodchuck / physiology; Hepatitis B, Chronic / drug therapy; Hepatitis B, Chronic / immunology; Hepatitis B, Chronic / therapy; Interferon-gamma / genetics; Interferon-gamma / immunology; Marmota; Treatment Outcome; Tumor Necrosis Factor-alpha / genetics; Tumor Necrosis Factor-alpha / immunology; beta-Galactosidase / genetics
TL;DR:
therapy of chronic woodchuck hepatitis virus (WHV) infections is evaluated using treatment with the nucleoside analog clevudine and therapy with adenovirus vectors expressing INF-gamma, TNF-alpha, and beta-galactosidase and the effect took at least 2 weeks to develop suggesting that the declines in the percentage of WHV-infected cells, ccc, and total WHV DNA resulted from induction of the adaptive immune response by the aden
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Woodchuck interleukin-6 gene: structure,characterization, and biologic activity
GENE, 342(1), 157–164.
author keywords: interleukin-6; woodchuck hepatitis virus; human hepatitis B virus
MeSH headings : Animals; Base Sequence; Binding Sites / genetics; Cell Division / drug effects; Cell Line, Tumor; DNA, Complementary / chemistry; DNA, Complementary / genetics; DNA, Complementary / isolation & purification; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Exons; Genes / genetics; Humans; Interleukin-6 / genetics; Interleukin-6 / metabolism; Interleukin-6 / pharmacology; Introns; Marmota / genetics; Marmota / metabolism; Molecular Sequence Data; Promoter Regions, Genetic / genetics; Recombinant Proteins / metabolism; Recombinant Proteins / pharmacology; Sequence Alignment; Sequence Analysis, DNA; Sequence Homology, Nucleic Acid; Transcription Factors / metabolism
TL;DR:
To demonstrate biologic activity, woodchuck IL-6 was expressed and it was shown that the purified recombinant protein induced terminal differentiation, as reflected by upregulation of Fcgamma receptor expression, and substantially inhibited proliferation of M1 cells, a murine myeloid leukemia cell line.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2003 journal article
Detection of Bartonella henselae and Bartonella clarridgeiae DNA in hepatic specimens from two dogs with hepatic disease
Journal of the American Veterinary Medical Association, 222(1), 47–51.
MeSH headings : Animals; Bartonella / genetics; Bartonella / isolation & purification; Bartonella Infections / diagnosis; Bartonella Infections / microbiology; Bartonella Infections / pathology; Bartonella Infections / veterinary; Bartonella henselae / genetics; Bartonella henselae / isolation & purification; DNA, Bacterial / analysis; Dog Diseases / diagnosis; Dog Diseases / microbiology; Dog Diseases / pathology; Dogs; Female; Liver / microbiology; Liver / pathology; Liver Diseases / diagnosis; Liver Diseases / microbiology; Liver Diseases / pathology; Liver Diseases / veterinary; Polymerase Chain Reaction / veterinary
TL;DR:
Identification of Bartonella DNA in these dogs indicates the need for future prospective studies to determine the clinical relevance of Bart onella spp infection in dogs with hepatic disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2002 journal article
Helicobacter marmotae sp nov isolated from livers of woodchucks and intestines of cats
JOURNAL OF CLINICAL MICROBIOLOGY, 40(7), 2513–2519.
MeSH headings : Animals; Base Sequence; Cats / microbiology; Cocarcinogenesis; DNA, Bacterial / genetics; Disease Models, Animal; Helicobacter / classification; Helicobacter / genetics; Helicobacter / isolation & purification; Helicobacter / pathogenicity; Hepatitis B / etiology; Hepatitis B Virus, Woodchuck / isolation & purification; Hepatitis B Virus, Woodchuck / pathogenicity; Humans; Liver / microbiology; Liver / pathology; Liver / virology; Liver Neoplasms, Experimental / etiology; Marmota / microbiology; Mice; Microscopy, Electron; Molecular Sequence Data; Phylogeny; RNA, Bacterial / genetics; RNA, Ribosomal, 16S / genetics; Species Specificity
TL;DR:
Four additional bacterial strains isolated from feces of cats and characterized by biochemical, phenotypic, and 16S rRNA analysis were determined to be identical to the woodchuck isolate, and the name Helicobacter marmotae sp.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2001 journal article
Antiviral efficacy and pharmacokinetics of oral adefovir dipivoxil in chronically woodchuck hepatitis virus-infected woodchucks
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 45(10), 2740–2745.
MeSH headings : Adenine / analogs & derivatives; Adenine / pharmacokinetics; Adenine / therapeutic use; Administration, Oral; Animals; Chemistry, Clinical; Chronic Disease; DNA, Viral / blood; Disease Models, Animal; Hepatitis B / blood; Hepatitis B / drug therapy; Hepatitis B / metabolism; Hepatitis B Virus, Woodchuck / drug effects; Liver / drug effects; Liver / pathology; Marmota; Organophosphonates; Treatment Outcome
TL;DR:
Under the conditions of this study, adefovir dipivoxil was an effective antihepadnaviral agent and no histologic evidence of liver injury was apparent in the biopsies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2001 article
Idiopathic noncirrhotic portal hypertension in dogs: 33 cases (1982-1998)
Bunch, S. E., Johnson, S. E., & Cullen, J. M. (2001, February 1). JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 218, pp. 392–399.
MeSH headings : Alanine Transaminase / blood; Alkaline Phosphatase / blood; Animals; Ascites / veterinary; Biopsy / veterinary; Blood Chemical Analysis / veterinary; Diarrhea / veterinary; Dog Diseases / diagnostic imaging; Dog Diseases / pathology; Dog Diseases / therapy; Dogs; Exudates and Transudates; Female; Histocytochemistry / veterinary; Hypertension, Portal / diagnostic imaging; Hypertension, Portal / pathology; Hypertension, Portal / therapy; Hypertension, Portal / veterinary; Liver / diagnostic imaging; Liver / pathology; Male; Portacaval Shunt, Surgical / veterinary; Radiography; Retrospective Studies; Treatment Outcome; Ultrasonography; Urinalysis / veterinary; Vomiting / veterinary
TL;DR:
The clinical signs, clinicopathologic test results, portal pressure, and gross appearance of the liver of dogs with idiopathic noncirrhotic portal hypertension may be identical to those of Dogs with cirrhosis; therefore liver biopsy is crucial.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2001 journal article
Kinetics of hepadnavirus loss from the liver during inhibition of viral DNA synthesis
JOURNAL OF VIROLOGY, 75(1), 311–322.
MeSH headings : Amino Acid Sequence; Animals; Antiviral Agents / pharmacology; Arabinofuranosyluracil / analogs & derivatives; Arabinofuranosyluracil / pharmacology; DNA, Circular / analysis; DNA, Viral / analysis; DNA, Viral / biosynthesis; Drug Resistance; Hepatitis B Virus, Woodchuck / drug effects; Hepatitis B Virus, Woodchuck / genetics; Hepatocytes / virology; Kinetics; Lamivudine / pharmacology; Marmota; Molecular Sequence Data
TL;DR:
The loss of cccDNA was comparable to that expected from the estimated death rate of hepatocytes in these woodchucks, suggesting that death of infected cells was one of the major routes for elimination of cCCDNA.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2001 journal article
T-helper cell response to woodchuck hepatitis virus antigens after therapeutic vaccination of chronically-infected animals treated with lamivudine
JOURNAL OF HEPATOLOGY, 35(1), 105–111.
author keywords: woodchuck hepatitis virus; lamivudine; Th1/Th2; therapeutic vaccination
MeSH headings : Animals; Antigens, Viral / immunology; Chronic Disease; Hepatitis B / immunology; Hepatitis B / therapy; Hepatitis B / virology; Hepatitis B Virus, Woodchuck / drug effects; Hepatitis B Virus, Woodchuck / immunology; Immunotherapy, Active; Lamivudine / therapeutic use; Liver / drug effects; Liver / pathology; Marmota; Reverse Transcriptase Inhibitors / therapeutic use; T-Lymphocytes, Helper-Inducer / immunology; Viral Load; Viremia / virology
TL;DR:
It is suggested that therapeutic vaccination of chronically-infected woodchucks under conditions of low viremia shifts the cytokine profile against viral antigens towards Th0/Th1, which may prevent the efficient induction of anti-WHs antibodies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Sustained survival of human hepatocytes in mice: A model for in vivo infection with human hepatitis B and hepatitis delta viruses
Nature Medicine, 6(3), 327–331.
MeSH headings : Animals; Cell Transplantation; Disease Models, Animal; Hepatitis B / pathology; Hepatitis B / transmission; Hepatitis B virus / isolation & purification; Hepatitis D / pathology; Hepatitis D / transmission; Hepatitis Delta Virus / isolation & purification; Humans; Liver / cytology; Liver / pathology; Liver / virology; Mice; Mice, Inbred NOD; Mice, SCID; Proto-Oncogene Proteins c-met / immunology; Time Factors; Transplantation, Heterologous
TL;DR:
A new xenotransplant model that allows study of multiple aspects of human hepatitis viral infections, and may enhance studies of human liver diseases, is described.
(via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018
2000 journal article
Woodchuck lymphotoxin-alpha, -beta and tumor necrosis factor genes: structure, characterization and biological activity
GENE, 242(1-2), 295–305.
author keywords: cDNA; cytotoxicity; gene; LT; TNF; transcription factor binding site
MeSH headings : Animals; Base Sequence; Binding Sites; Cell Line; DNA / chemistry; DNA / genetics; DNA / metabolism; DNA, Complementary / chemistry; DNA, Complementary / genetics; DNA, Complementary / isolation & purification; Exons; Gene Expression; Genes / genetics; Glutathione Transferase / genetics; Glutathione Transferase / metabolism; Humans; Introns; Lymphotoxin-alpha / genetics; Lymphotoxin-alpha / metabolism; Lymphotoxin-alpha / pharmacology; Lymphotoxin-beta; Marmota / genetics; Membrane Proteins / genetics; Membrane Proteins / metabolism; Molecular Sequence Data; Polymorphism, Genetic; Promoter Regions, Genetic; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / metabolism; Recombinant Fusion Proteins / pharmacology; Sequence Analysis, DNA; Sequence Homology, Nucleic Acid; Transcription Factors / metabolism; Tumor Cells, Cultured / cytology; Tumor Cells, Cultured / drug effects; Tumor Necrosis Factor-alpha / genetics; Tumor Necrosis Factor-alpha / metabolism; Tumor Necrosis Factor-alpha / pharmacology
TL;DR:
The data obtained from this study will be useful to future investigations of the TNF and LT anti-tumor and anti-viral activities, and their therapeutic potential in the woodchuck model for human hepatitis B virus (HBV).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1999 journal article
Hydranencephaly and cerebellar hypoplasia in two kittens attributed to intrauterine parvovirus infection
JOURNAL OF COMPARATIVE PATHOLOGY, 121(1), 39–53.
MeSH headings : Animals; Brain / abnormalities; Brain / virology; Cat Diseases / pathology; Cat Diseases / virology; Cats; Cerebellum / pathology; Cerebellum / virology; Cytopathogenic Effect, Viral; Female; Hydranencephaly / pathology; Hydranencephaly / veterinary; Hydranencephaly / virology; Parvoviridae Infections / complications; Parvoviridae Infections / pathology; Parvoviridae Infections / veterinary; Parvovirus; Polymerase Chain Reaction / veterinary; Pregnancy; Vaccines, Attenuated / administration & dosage; Vaccines, Attenuated / adverse effects; Viral Vaccines / administration & dosage; Viral Vaccines / adverse effects
TL;DR:
Six weeks after vaccination with modified live feline parvovirus vaccine, a cat gave birth to five kittens, three of which died soon afterwards, and two kittens survived, but at 8 weeks of age were unable to walk and showed abnormal behaviour, which suggested multifocal disease associated with the cerebrum and cerebellum.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
1998 journal article
Lamivudine therapy of WHV-infected woodchucks
VIROLOGY, 245(1), 18–32.
MeSH headings : Amino Acid Sequence; Animals; DNA Replication / drug effects; DNA, Viral / drug effects; DNA, Viral / genetics; Hepatitis B virus / isolation & purification; Hepatitis B virus / physiology; Hepatitis B, Chronic / drug therapy; Lamivudine / therapeutic use; Marmota; Molecular Sequence Data; Reverse Transcriptase Inhibitors / therapeutic use; Virus Replication / drug effects
TL;DR:
Not unexpectedly, the lamivudine therapy did not have a impact on development of liver cancer and three types of mutation that may be associated with drug resistance were found at this time, in a region upstream of the YMDD motif in the active site of the viral reverse transcriptase.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1997 journal article
In vivo antiviral activity and pharmacokinetics of (-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine in woodchuck hepatitis virus-infected woodchucks
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 41(10), 2076–2082.
MeSH headings : Animals; Antiviral Agents / pharmacokinetics; Antiviral Agents / therapeutic use; DNA, Viral / analysis; DNA, Viral / biosynthesis; Emtricitabine / analogs & derivatives; Half-Life; Hepatitis B / drug therapy; Hepatitis B / virology; Hepatitis B Virus, Woodchuck; Liver / cytology; Liver / metabolism; Liver / virology; Marmota / virology; Stereoisomerism; Zalcitabine / analogs & derivatives; Zalcitabine / pharmacokinetics; Zalcitabine / therapeutic use
TL;DR:
It is concluded that (-)-FTC is a potent antihepadnaviral agent and that it has no detectable toxic effects in woodchucks when given for up to 25 days, and as an anti-hepatitis B virus therapy for patients is warranted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1997 journal article
Therapeutic vaccination of woodchucks against chronic woodchuck hepatitis virus infection
JOURNAL OF HEPATOLOGY, 27(4), 726–737.
author keywords: antibodies; hepatitis; immune therapy; peptides; T-cell help; vaccination; woodchuck; woodchuck hepatitis virus (WHV); woodchuck hepatitis virus surface antigen (WHsAg)
MeSH headings : Amino Acid Sequence; Animals; Biopsy; Chronic Disease; Disease Models, Animal; Hepatitis B / pathology; Hepatitis B / prevention & control; Hepatitis B Vaccines; Liver / pathology; Marmota / immunology; Molecular Sequence Data; Rodent Diseases / prevention & control
TL;DR:
Co-immunization of chronically infected woodchucks with surface antigen and a peptide recognized by T helper cells produces a good anti-surface antibody response, however, this strategy needs to be optimized before its implementation in humans.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1993 journal article
HISTOLOGIC CHARACTERIZATION OF HEPATIC CARCINOGENESIS IN TRANSGENIC MICE EXPRESSING SV40 T-ANTIGENS
VETERINARY PATHOLOGY, 30(2), 111–118.
author keywords: LIVER; NEOPLASIA; ONCOGENE; SIMIAN VIRUS-40; T-ANTIGENS; TRANSGENIC MICE
MeSH headings : Adenoma, Bile Duct / pathology; Animals; Antigens, Polyomavirus Transforming / genetics; Antigens, Viral, Tumor / genetics; Bile Duct Neoplasms / pathology; Bile Ducts, Intrahepatic / pathology; Female; Gene Expression Regulation, Neoplastic; Liver / pathology; Liver / ultrastructure; Liver Neoplasms / immunology; Liver Neoplasms / pathology; Liver Neoplasms, Experimental / pathology; Male; Mice; Mice, Transgenic; Organ Size; Time Factors
TL;DR:
These experiments, in which viral oncogene expression is targeted to all hepatocytes, support the multistage hypothesis of tumor development and illustrate the similarities in morphologic response of liver to a variety of carcinogenic insults.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1990 journal article
Hepatic neoplasms in aflatoxin B1-treated, congenital duck hepatitis B virus-infected, and virus-free Pekin ducks
Cancer Research, 50(13), 4072.
Source: NC State University Libraries
Added: August 6, 2018
1987 journal article
Pathologic manifestations of experimental Babesia microti infection in hamsters
Laboratory Animal Science, 37, 640–643.
Source: NC State University Libraries
Added: August 6, 2018
journal article
The MTAP-CDKN2A locus confers susceptibility to a naturally occurring canine cancer
Shearin, A. L., Hedan, B., Cadieu, E., Erich, S. A., Schmidt, E. V., Faden, D. L., … Andre, C. Cancer Epidemiology Biomarkers, 21(7), 1019–1027.
Source: NC State University Libraries
Added: August 6, 2018
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