Works (114)

Updated: August 29th, 2023 05:01

2023 article

Assessment of Mouse Liver Histopathology Following Exposure to HFPO-DA With Emphasis on Understanding Mechanisms of Hepatocellular Death

Thompson, C. M., Heintz, M. M., Wolf, J. C., Cheru, R., Haws, L. C., & Cullen, J. M. (2023, March 29). TOXICOLOGIC PATHOLOGY.

By: C. Thompson*, M. Heintz*, J. Wolf*, R. Cheru*, L. Haws* & J. Cullen n

author keywords: liver; liver pathology; GenX; HFPO-DA; per- and polyfluoroalkyl substances (PFAS); peroxisome proliferator
Source: Web Of Science
Added: April 24, 2023

2023 article

Assessment of the mode of action underlying development of liver lesions in mice following oral exposure to HFPO-DA and relevance to humans

Heintz, M. M., Haws, L. C., Klaunig, J. E., Cullen, J. M., & Thompson, C. M. (2023, January 11). TOXICOLOGICAL SCIENCES.

By: M. Heintz*, L. Haws*, J. Klaunig*, J. Cullen n & C. Thompson*

author keywords: mode of action (MOA); liver; peroxisome proliferator-activated receptor alpha; (PPAR alpha); HFPO-DA (GenX); PFAS
MeSH headings : Humans; Mice; Animals; PPAR alpha / genetics; PPAR alpha / metabolism; Fluorocarbons / toxicity; Liver; Liver Neoplasms / metabolism; Rodentia / metabolism
Source: Web Of Science
Added: February 27, 2023

2023 journal article

Gallbladder microbiota in healthy dogs and dogs with mucocele formation

PLOS ONE, 18(2).

By: J. Gookin n, A. Hartley n, K. Aicher n, K. Mathews n, R. Cullen n, J. Cullen n, B. Callahan n, D. Stowe n ...

MeSH headings : Dogs; Animals; Gallbladder / pathology; Mucocele / veterinary; RNA, Ribosomal, 16S / genetics; Bile / microbiology; Gallbladder Diseases / veterinary; Microbiota / genetics; Bile Duct Diseases; Dog Diseases / diagnosis
Sources: Web Of Science, ORCID
Added: April 24, 2023

2023 article

Histologic characterization of the major duodenal papilla and association with concurrent biliary, pancreatic, and intestinal pathology in cats

Schreeg, M. E., Cullen, J. M., Robertson, J., & Gookin, J. L. (2023, August 10). VETERINARY PATHOLOGY, Vol. 8.

By: M. Schreeg n, J. Cullen n, J. Robertson n & J. Gookin n

author keywords: ampulla of Vater; cat; cholangitis; enteritis; lymphoma; major duodenal papillitis; pancreatitis
Sources: Web Of Science, ORCID
Added: August 21, 2023

2023 journal article

Immunohistochemical characterization of clear cell variant of hepatocellular carcinoma in a sheep

JOURNAL OF COMPARATIVE PATHOLOGY, 204, 47–50.

By: K. Hughes*, M. Radakovic*, F. Gorman*, B. Malinowska & J. Cullen n

author keywords: arginase 1; clear cell; hepatocellular carcinoma; liver; pathology; sheep; tumour
Source: Web Of Science
Added: August 28, 2023

2023 article

Patent hepatic ciliated foregut remnant resulting in an umbilicobiliary sinus tract, with gallbladder agenesis, in an 8-wk-old male French Bulldog

Wong, H. E., Cullen, J. M., Vila-Gonzalez, M., Pittaway, R., Desmet, V. J., & Gillian, T. D. (2023, January 4). JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION.

By: H. Wong, J. Cullen n, M. Vila-Gonzalez*, R. Pittaway, V. Desmet* & T. Gillian*

author keywords: agenesis; cilia; cysts; dogs; embryonic structures; foregut remnant; fluorescent antibody technique; gallbladder; liver
MeSH headings : Animals; Dogs; Male; Cilia / pathology; Dog Diseases / diagnosis; Dog Diseases / surgery; Dog Diseases / pathology; Gallbladder / pathology; Inflammation / pathology; Inflammation / veterinary; Liver Diseases / pathology; Liver Diseases / veterinary
Source: Web Of Science
Added: January 23, 2023

2023 journal article

Viral protease cleavage of MAVS in genetically modified mice with hepatitis A virus infection

JOURNAL OF HEPATOLOGY, 78(2), 271–280.

By: L. Sun, H. Feng, I. Misumi, T. Shirasaki, L. Hensley, O. Gonzalez-Lopez, I. Shiota, W. Chou ...

author keywords: Innate immunity; Species barrier; Interferon; Animal model; 3ABC protease; inflammation; Viral replication; CRISPR
MeSH headings : Animals; Mice; Humans; Hepatitis A virus / genetics; Peptide Hydrolases; Mice, Inbred C57BL; Hepatitis A; Immunity, Innate; Viral Proteases
Source: Web Of Science
Added: April 24, 2023

2022 article

Hepatocellular carcinomas in captive prosimians

Robveille, C., & Cullen, J. M. (2022, July 25). VETERINARY PATHOLOGY.

By: C. Robveille* & J. Cullen n

author keywords: hepatocellular carcinoma; lemur; metastasis; neoplasm; prosimians; cytokeratin 7; cytokeratin 19
MeSH headings : Animals; Biomarkers, Tumor; Carcinoma, Hepatocellular / diagnosis; Carcinoma, Hepatocellular / veterinary; Immunohistochemistry; Keratin-19; Keratin-7; Liver Neoplasms / diagnosis; Liver Neoplasms / veterinary; Paraffin; Retrospective Studies; Strepsirhini
Source: Web Of Science
Added: August 1, 2022

2022 journal article

The ZCCHC14/TENT4 complex is required for hepatitis A virus RNA synthesis

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119(28).

By: Y. Li*, I. Misumi*, T. Shiota*, L. Sun*, E. Lenarcic*, H. Kim*, T. Shirasaki*, A. Hertel-Wulff* ...

author keywords: picornavirus; antiviral therapy; animal model; hepatitis A; RNA-binding protein
MeSH headings : Animals; Antiviral Agents / pharmacology; Antiviral Agents / therapeutic use; Chromosomal Proteins, Non-Histone / metabolism; DNA-Directed DNA Polymerase / metabolism; Hepatitis A / drug therapy; Hepatitis A / metabolism; Hepatitis A / virology; Hepatitis A virus / drug effects; Hepatitis A virus / genetics; Hepatitis A virus / physiology; Humans; Intrinsically Disordered Proteins / metabolism; Mice; Mice, Mutant Strains; RNA Nucleotidyltransferases / metabolism; RNA, Viral / biosynthesis; RNA, Viral / genetics; Receptor, Interferon alpha-beta / genetics; Virus Replication / drug effects
Source: Web Of Science
Added: September 29, 2022

2021 article

Choledochal cyst with secondary cholangitis, choledochitis, duodenal papillitis, and pancreatitis in a young domestic shorthair cat

Schreeg, M. E., Miller, S. A., & Cullen, J. M. (2021, May 24). JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION.

By: M. Schreeg n, S. Miller & J. Cullen n

author keywords: bile ducts; cats; cholangitis; choledochal cyst; congenital; liver; pancreatitis
MeSH headings : Animals; Cat Diseases / diagnosis; Cat Diseases / pathology; Cats; Cholangitis / diagnosis; Cholangitis / etiology; Cholangitis / veterinary; Choledochal Cyst / complications; Choledochal Cyst / veterinary; Duodenal Diseases / diagnosis; Duodenal Diseases / etiology; Duodenal Diseases / veterinary; Female; Pancreatitis / diagnosis; Pancreatitis / etiology; Pancreatitis / veterinary
Source: Web Of Science
Added: June 10, 2021

2021 article

Ductal Plate Malformations in Captive Snakes

Patania, O. M., Troan, B. V., & Cullen, J. M. (2021, May 3). VETERINARY PATHOLOGY.

By: O. Patania n, B. Troan n & J. Cullen n

author keywords: bile ducts; ductal plate malformation; immunohistochemistry; liver; polycystic liver disease; snake; von Meyenburg complex
MeSH headings : Animals; Bile Ducts; Bile Ducts, Intrahepatic; Cysts / veterinary; Liver Diseases / veterinary; Snakes
Source: Web Of Science
Added: June 14, 2021

2021 journal article

IRF3-mediated pathogenicity in a murine model of human hepatitis A

PLOS PATHOGENS, 17(9).

By: L. Sun*, Y. Li*, I. Misumi*, O. Gonzalez-Lopez*, L. Hensley*, J. Cullen n, D. McGivern*, M. Matsuda* ...

MeSH headings : Animals; Disease Models, Animal; Hepatitis A / metabolism; Hepatitis A / pathology; Interferon Regulatory Factor-3 / metabolism; Liver / pathology; Mice; Mice, Knockout; Transcriptome
Source: Web Of Science
Added: February 28, 2022

2021 journal article

Iminosugar Glucosidase Inhibitors Reduce Hepatic Inflammation in Hepatitis A Virus-Infected Ifnar1(-/-) Mice

JOURNAL OF VIROLOGY, 95(11).

By: I. Misumi, Z. Li, L. Sun, A. Das, T. Shiota, J. Cullen, Q. Zhang, J. Whitmire, S. Lemon

author keywords: antiviral agents; ganglioside; hepatitis A virus; host response; iminosugar; liver immunology; miglustat; picornavirus
Source: Web Of Science
Added: June 10, 2021

2021 article

International Guidelines for Veterinary Tumor Pathology: A Call to Action

Meuten, D. J., Moore, F. M., Donovan, T. A., Bertram, C. A., Klopfleisch, R., Foster, R. A., … Whitley, D. (2021, July 20). VETERINARY PATHOLOGY.

By: D. Meuten n, F. Moore*, T. Donovan*, C. Bertram*, R. Klopfleisch*, R. Foster*, R. Smedley*, M. Dark* ...

author keywords: standardization; oncology; guidelines; protocols; validation
MeSH headings : Animals; Neoplasms / diagnosis; Neoplasms / veterinary; Pathology, Veterinary; Reproducibility of Results
Source: Web Of Science
Added: August 2, 2021

2021 review

International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of the Dog

[Review of ]. TOXICOLOGIC PATHOLOGY, 49(1), 5–109.

By: J. Woicke, M. Al-Haddawi*, J. Bienvenu, J. Caverly Rae, F. Chanut*, K. Colman*, J. Cullen n, W. Davis* ...

author keywords: dog; pathology; toxicopathology; nomenclature; background findings; INHAND
MeSH headings : Animals; Animals, Laboratory; Databases, Factual; Dogs; Europe; Japan
Source: Web Of Science
Added: February 1, 2021

2021 journal article

T cells protect against hepatitis A virus infection and limit infection- induced liver injury

JOURNAL OF HEPATOLOGY, 75(6), 1323–1334.

author keywords: Hepatitis A Virus; mice; liver infection; liver pathogenesis; T cells; T cell vaccine; type-1 interferons
MeSH headings : Analysis of Variance; Animals; Disease Models, Animal; Hepatitis A / drug therapy; Hepatitis A / epidemiology; Hepatitis A / prevention & control; Hepatitis A virus / drug effects; Hepatitis A virus / pathogenicity; Liver Diseases / drug therapy; Liver Diseases / epidemiology; Liver Diseases / prevention & control; Mice; North Carolina; Statistics, Nonparametric; T-Lymphocytes / metabolism; T-Lymphocytes / physiology
Source: Web Of Science
Added: December 13, 2021

2021 journal article

Using rheology to quantify the effects of localized collagenase treatments on uterine fibroid digestion

ACTA BIOMATERIALIA, 134, 443–452.

By: R. Corder n, S. Gadi n, R. Vachieri*, F. Jayes*, J. Cullen n, S. Khan n, D. Taylor*

author keywords: Uterine fibroids; Collagenase; Drug delivery; Rheology; Histology
MeSH headings : Animals; Collagenases; Digestion; Female; Humans; Leiomyoma / drug therapy; Mice; Rheology; Treatment Outcome; Uterine Neoplasms
Sources: Web Of Science, ORCID
Added: November 8, 2021

2020 review

An adverse outcome pathway for small intestinal tumors in mice involving chronic cytotoxicity and regenerative hyperplasia: a case study with hexavalent chromium, captan, and folpet

[Review of ]. CRITICAL REVIEWS IN TOXICOLOGY, 50(8), 685–706.

By: V. Bhat*, S. Cohen*, E. Gordon, C. Wood*, J. Cullen n, M. Harris*, D. Proctor*, C. Thompson*

author keywords: Adverse outcome pathway (AOP); small intestinal tumors; villous cytotoxicity; regenerative proliferation; crypt hyperplasia; cytotoxicity-mediated; non-DNA-reactive; mode of action (MOA); weight of evidence; hexavalent chromium; captan; folpet
MeSH headings : Adverse Outcome Pathways; Animals; Captan / toxicity; Chromium / toxicity; Duodenum; Fungicides, Industrial / toxicity; Humans; Hyperplasia; Intestinal Neoplasms / chemically induced; Mice; Phthalimides / toxicity; Risk Assessment
Source: Web Of Science
Added: November 24, 2020

2020 journal article

Assessment of the Mode of Action Underlying the Effects of GenX in Mouse Liver and Implications for Assessing Human Health Risks

TOXICOLOGIC PATHOLOGY, 48(3), 494–508.

author keywords: transcriptomics; perfluoroalkyl and polyfluoroalkyl substances (PFAS); GenX; mode of action; single-cell necrosis; peroxisome proliferator-activated receptor alpha (PPAR alpha)
MeSH headings : Animals; Female; Humans; Hydrocarbons, Fluorinated / toxicity; Liver / drug effects; Male; Mice; PPAR alpha / drug effects; Propionates / toxicity; Risk Assessment; Transcriptome / drug effects
Source: Web Of Science
Added: April 20, 2020

2020 journal article

Inter-Institutional Partnerships to Develop Veterinarian-Investigators through the NIH Comparative Biomedical Scientist Training Program Benefit One Health Goals

JOURNAL OF VETERINARY MEDICAL EDUCATION, 47(5), 619–631.

By: R. Simpson, S. Hoover, B. Davis, J. Hickerson, M. Miller, M. Kiupel, J. Cullen*, J. Dwyer ...

author keywords: clinician-scientist; graduate education; veterinary medical education; investigative pathologist; veterinary specialty; veterinary pathology; DVM/PhD; comparative medicine; predictive translational modeling; NIH intramural research training award (IRTA); NCI cancer research training award (CRTA)
MeSH headings : Animals; Biomedical Research; Education, Veterinary; Goals; Humans; National Institutes of Health (U.S.); One Health; United States; Veterinarians
Source: Web Of Science
Added: December 21, 2020

2019 journal article

Comparative Pathology of Hepatitis A Virus and Hepatitis E Virus Infection

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 9(4).

By: J. Cullen n & S. Lemon*

MeSH headings : Animals; Disease Models, Animal; Hepatitis A / pathology; Hepatitis A / virology; Hepatitis A virus; Hepatitis E / pathology; Hepatitis E / virology; Hepatitis E virus; Humans; Liver / pathology; Phylogeny; Primates
Source: Web Of Science
Added: April 15, 2019

2019 journal article

Computed Tomography of Lobular Dissecting Hepatitis in a Young Golden Retriever

JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION, 55(2).

By: E. Hostnik n, V. Parker n & J. Cullen n

MeSH headings : Aging; Amoxicillin / therapeutic use; Animal Feed / analysis; Animals; Anti-Bacterial Agents / therapeutic use; Dietary Proteins / administration & dosage; Dog Diseases / diagnostic imaging; Dog Diseases / etiology; Dog Diseases / pathology; Dog Diseases / therapy; Dogs; Female; Gastrointestinal Agents / therapeutic use; Hepatic Encephalopathy / drug therapy; Hepatic Encephalopathy / etiology; Hepatic Encephalopathy / veterinary; Hepatitis, Animal / complications; Hepatitis, Animal / diagnostic imaging; Hepatitis, Animal / pathology; Hepatitis, Animal / therapy; Lactulose / therapeutic use; Liver / diagnostic imaging; Liver / pathology; Omeprazole / therapeutic use; Tomography, X-Ray Computed / veterinary
Source: Web Of Science
Added: March 4, 2019

2019 journal article

Development of an oral reference dose for the perfluorinated compound GenX

JOURNAL OF APPLIED TOXICOLOGY, 39(9), 1267–1282.

By: C. Thompson*, S. Fitch*, C. Ring*, W. Rish*, J. Cullen n & L. Haws*

author keywords: benchmark dose (BMD) modeling; GenX; per- and polyfluoroalkyl substances (PFAS); reference dose (RfD); risk assessment
MeSH headings : Animals; Benchmarking; Drinking Water / standards; Humans; Hydrocarbons, Fluorinated / toxicity; Lethal Dose 50; Models, Animal; No-Observed-Adverse-Effect Level; Propionates / toxicity; Rats; Reference Standards; United States; Water Pollutants, Chemical / toxicity
Source: Web Of Science
Added: September 9, 2019

2019 journal article

Reevaluation of Hepatocellular Neoplasms in CD-1 Mice from a 2-year Oral Carcinogenicity Study with Permethrin

TOXICOLOGIC PATHOLOGY, 47(1), 11–17.

By: E. Quist*, G. Boorman*, J. Cullen n, R. Maronpot*, A. Remick*, J. Swenberg*, L. Freshwater, J. Hardisty*

author keywords: permethrin; liver neoplasms; hepatocellular adenoma; hepatocellular carcinoma; Pathology Working Group
MeSH headings : Administration, Oral; Animals; Carcinogenicity Tests; Carcinogens / toxicity; Dose-Response Relationship, Drug; Female; Liver Neoplasms / chemically induced; Liver Neoplasms / pathology; Liver Neoplasms, Experimental / chemically induced; Liver Neoplasms, Experimental / pathology; Male; Mice, Inbred Strains; Permethrin / toxicity; Sex Factors
Source: Web Of Science
Added: February 11, 2019

2019 journal article

Virus discovery reveals frequent infection by diverse novel members of the Flaviviridae in wild lemurs

ARCHIVES OF VIROLOGY, 164(2), 509–522.

By: M. Canuti*, C. Williams*, S. Sagan*, B. Munnink*, S. Gadi n, J. Verhoeven*, P. Kellam*, M. Cotten* ...

MeSH headings : Animals; Flaviviridae / classification; Flaviviridae / genetics; Flaviviridae / isolation & purification; Flaviviridae / physiology; Flaviviridae Infections / veterinary; Flaviviridae Infections / virology; Genetic Variation; Lemur / virology; Madagascar; Phylogeny; Primate Diseases / virology
Source: Web Of Science
Added: March 4, 2019

2018 journal article

EVALUATION OF THE OPHTHALMIC DISEASE AND HISTOPATHOLOGIC EFFECTS DUE TO THE OCULAR TREMATODE PHILOPHTHALMUS ZALOPHI ON JUVENILE GALAPAGOS SEA LIONS (ZALOPHUS WOLLEBAEKI)

JOURNAL OF ZOO AND WILDLIFE MEDICINE, 49(3), 581–590.

By: B. Phillips, D. Paez-Rosas, J. Flowers*, J. Cullen*, J. Law*, C. Colitz, D. Deresienski*, K. Lohmann, G. Lewbart*

author keywords: Conjunctival biopsy; eye trematode; Galapagos sea lion; Philophthalmus zalophi; Zalophus wollebaeki
MeSH headings : Aging; Animals; Ecuador / epidemiology; Eye Diseases / epidemiology; Eye Diseases / parasitology; Eye Diseases / veterinary; Sea Lions / parasitology; Trematoda / classification; Trematode Infections / epidemiology; Trematode Infections / parasitology; Trematode Infections / veterinary
Sources: Web Of Science, ORCID
Added: January 21, 2019

2018 journal article

Evaluation of potential serum biomarkers of hepatic fibrosis and necroinflammatory activity in dogs with liver disease

JOURNAL OF VETERINARY INTERNAL MEDICINE, 32(3), 1009–1018.

By: C. Raghu*, J. Ekena*, J. Cullen n, C. Webb* & L. Trepanier*

author keywords: AST; CCL2; CRP; hepatitis; IL-6; MCP-1
MeSH headings : Alanine Transaminase / blood; Animals; Aspartate Aminotransferases / blood; Biomarkers / blood; Biopsy / veterinary; Chemokine CCL2 / blood; Cross-Sectional Studies; Dog Diseases / blood; Dog Diseases / diagnosis; Dogs; Female; Interleukin-6 / blood; Liver / pathology; Liver Cirrhosis / blood; Liver Cirrhosis / diagnosis; Liver Cirrhosis / veterinary; Liver Diseases / blood; Liver Diseases / diagnosis; Liver Diseases / veterinary; Male; Necrosis; Prospective Studies
Source: Web Of Science
Added: August 6, 2018

2018 journal article

MORTALITY IN COQUEREL'S SIFAKAS (PROPITHECUS COQUERELI) UNDER HUMAN CARE: A RETROSPECTIVE SURVEY FROM THE DUKE LEMUR CENTER 1990-2015

JOURNAL OF ZOO AND WILDLIFE MEDICINE, 49(2), 315–323.

By: K. Cassady, J. Cullen* & C. Williams

author keywords: Coquerel's sifaka; lemur; mortality; Propithecus coquereli; prosimian
MeSH headings : Age Factors; Animals; Animals, Zoo; Endangered Species; Mortality; North Carolina / epidemiology; Retrospective Studies; Strepsirhini
Source: Web Of Science
Added: August 6, 2018

2018 journal article

New parvovirus associated with serum hepatitis in horses after inoculation of common biological product

Emerging Infectious Diseases, 24(2), 303–310.

By: T. Divers, B. Tennant, A. Kumar, S. McDonough, J. Cullen, N. Bhuva, K. Jain, L. Chauhan ...

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

Qualitative metabolomics profiling of serum and bile from dogs with gallbladder mucocele formation

PLOS ONE, 13(1).

By: J. Gookin n, K. Mathews n, J. Cullen n & G. Seiler n

MeSH headings : Animals; Bile / metabolism; Blood; Dogs; Female; Gallbladder Diseases / blood; Gallbladder Diseases / metabolism; Male; Metabolomics; Mucocele / blood; Mucocele / metabolism
Sources: Web Of Science, ORCID
Added: August 6, 2018

2018 journal article

Viral persistence, liver disease, and host response in a hepatitis C-like virus rat model

Hepatology, 68(2), 435–448.

By: S. Trivedi*, S. Murthy*, H. Sharma*, A. Hartlage*, A. Kumar*, S. Gadi n, P. Simmonds*, L. Chauhan* ...

MeSH headings : Alanine Transaminase; Animals; Antiviral Agents / pharmacology; Disease Models, Animal; Gene Expression Profiling / methods; Hepacivirus / genetics; Hepacivirus / pathogenicity; Hepatitis C / genetics; Hepatitis C / virology; Liver Diseases / virology; MicroRNAs / genetics; RNA, Viral / genetics; Rats; Rats, Sprague-Dawley; Sequence Analysis, DNA / methods; Virus Replication / genetics
Source: Crossref
Added: February 21, 2020

2017 journal article

Interobserver Agreement Using Histological Scoring of the Canine

JOURNAL OF VETERINARY INTERNAL MEDICINE, 31(3), 778–783.

By: J. Lidbury*, A. Hoffmann*, R. Ivanek*, J. Cullen n, B. Porter*, F. Oliveira, T. Van Winkle*, G. Grinwis*, J. Sucholdolski*, J. Steiner*

author keywords: Chronic hepatitis; Dog; Hepatic fibrosis; histological scoring
MeSH headings : Animals; Dog Diseases / pathology; Dogs; Fibrosis; Hepatitis, Animal / pathology; Humans; Liver / pathology; Observer Variation; Pathology, Veterinary / standards; Pathology, Veterinary / statistics & numerical data
Source: Web Of Science
Added: August 6, 2018

2017 journal article

MYCOBACTERIUM INTRACELLULARE INFECTION CAUSING A RETROPERITONEAL MASS IN A BINTURONG (ARCTICTIS BINTURONG)

JOURNAL OF ZOO AND WILDLIFE MEDICINE, 48(2), 544–548.

author keywords: Arctictis binturong; binturong; mycobacteriosis; Mycobacterium intracellulare; pyogranuloma
MeSH headings : Animals; Male; Mycobacterium avium Complex / isolation & purification; Mycobacterium avium-intracellulare Infection / pathology; Mycobacterium avium-intracellulare Infection / veterinary; Viverridae
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

Mouse models of acute and chronic hepacivirus infection

SCIENCE, 357(6347), 204-+.

MeSH headings : Animals; CD4-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / immunology; Disease Models, Animal; Hepacivirus / immunology; Hepatitis C / immunology; Hepatitis C, Chronic / immunology; Immunocompetence / immunology; Immunocompromised Host / immunology; Lymphocyte Depletion; Mice; Mice, Inbred C57BL
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Other viruses: Hepeviridae, hepadnaviridae, deltaviruses, nodaviridae, and unclassified viruses

Fenner's Veterinary Virology, 5th Edition, 547–555.

By: J. Cullen & X. Meng

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

TIM1 (HAVCR1) Is Not Essential for Cellular Entry of Either Quasi-enveloped or Naked Hepatitis A Virions

MBIO, 8(5).

By: A. Das*, A. Hirai-Yuki*, O. Gonzalez-Lopez*, B. Rhein*, S. Moller-Tank*, R. Brouillette*, L. Hensley*, I. Misumi* ...

author keywords: hepatitis A virus; hepatovirus; phosphatidylserine; picornavirus; receptor; viral attachment
MeSH headings : Animals; CRISPR-Cas Systems; Carcinoma, Hepatocellular; Cell Line, Tumor; Chlorocebus aethiops; Hepatitis A / virology; Hepatitis A Virus Cellular Receptor 1 / deficiency; Hepatitis A Virus Cellular Receptor 1 / genetics; Hepatitis A Virus Cellular Receptor 1 / metabolism; Hepatitis A virus / metabolism; Hepatitis A virus / pathogenicity; Hepatitis A virus / physiology; Host-Pathogen Interactions; Humans; Liver / pathology; Liver / physiopathology; Liver / virology; Mice; Receptor, Interferon alpha-beta / deficiency; Receptor, Interferon alpha-beta / genetics; Receptor, Interferon alpha-beta / metabolism; Vero Cells; Virion / metabolism; Virion / pathogenicity; Virion / physiology; Virus Attachment; Virus Internalization; Virus Replication
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Acute Alpha-Naphthylisothiocyanate-induced Liver Toxicity in Germfree and Conventional Male Rats

TOXICOLOGIC PATHOLOGY, 44(7), 987–997.

By: J. Cullen n, B. Faiola*, D. Melich*, R. Peterson*, H. Jordan*, C. Kimbrough*, R. Miller*

author keywords: liver; bile duct; alpha-naphthylisothiocyanate; germfree; rat; toxicity
MeSH headings : 1-Naphthylisothiocyanate / toxicity; Animals; Germ-Free Life / drug effects; Liver / drug effects; Male; Rats; Rats, Sprague-Dawley
Source: Web Of Science
Added: August 6, 2018

2016 journal article

External beam radiation therapy of squamous cell carcinoma in the beak of an African grey parrot (Psittacus timneh)

Journal of Avian Medicine and Surgery, 30(3), 250–256.

By: S. Swisher n, K. Phillips*, J. Tobias n, J. Cullen n, T. Gieger n & V. Grunkemeyer n

MeSH headings : Animals; Beak / pathology; Bird Diseases / radiotherapy; Carcinoma, Squamous Cell / radiotherapy; Carcinoma, Squamous Cell / veterinary; Male; Parrots
Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2016 journal article

Histiocytic chorioretinitis in a dog

Veterinary Ophthalmology, 21(1), 88–95.

By: A. Sherman n, J. Cullen n, H. Westermeyer n, C. Grindem n & B. Gilger n

author keywords: canine; chorioretinitis; histiocytic; Melan-A; melanoma; retinal detachment
MeSH headings : Animals; Chorioretinitis / diagnosis; Chorioretinitis / veterinary; Diagnosis, Differential; Diagnostic Techniques, Ophthalmological; Dog Diseases / diagnosis; Dogs; Eye Enucleation; Male
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2016 journal article

Histology Atlas of the Developing Mouse Hepatobiliary Hemolymphatic Vascular System with Emphasis on Embryonic Days 11.5-18.5 and Early Postnatal Development

TOXICOLOGIC PATHOLOGY, 44(5), 705–725.

author keywords: vascular development; lymphatic development; hepatobiliary development; portal sinus; embryo; mouse; atlas
MeSH headings : Anatomy, Artistic; Animals; Atlases as Topic; Biliary Tract / embryology; Blood Vessels / embryology; Embryo, Mammalian; Embryonic Development; Liver / embryology; Lymphatic System / embryology; Mice; Mice, Transgenic
Source: Web Of Science
Added: August 6, 2018

2016 journal article

MAVS-dependent host species range and pathogenicity of human hepatitis A virus

SCIENCE, 353(6307), 1541–1545.

By: A. Hirai-Yuki*, L. Hensley*, D. McGivern*, O. Gonzalez-Lopez*, A. Das*, H. Feng*, L. Sun*, J. Wilson* ...

MeSH headings : Adaptor Proteins, Signal Transducing / genetics; Adaptor Proteins, Signal Transducing / immunology; Animals; Apoptosis; Disease Models, Animal; Hepatitis A / immunology; Hepatitis A / pathology; Hepatitis A / virology; Hepatitis A virus / immunology; Hepatocytes / immunology; Hepatocytes / pathology; Hepatocytes / virology; Host-Pathogen Interactions / immunology; Humans; Interferon Regulatory Factor-3 / genetics; Interferon Regulatory Factor-3 / immunology; Interferon Regulatory Factor-7 / genetics; Interferon Regulatory Factor-7 / immunology; Interferon Type I / immunology; Liver / immunology; Liver / pathology; Liver / virology; Mice; Mice, Knockout; Receptor, Interferon alpha-beta / genetics; Receptor, Interferon alpha-beta / immunology; Receptors, Interferon / genetics; Receptors, Interferon / immunology; Signal Transduction / immunology; Species Specificity
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Reevaluation and Classification of Duodenal Lesions in B6C3F1 Mice and F344 Rats from 4 Studies of Hexavalent Chromium in Drinking Water

TOXICOLOGIC PATHOLOGY, 44(2), 279–289.

By: J. Cullen n, J. Ward* & C. Thompson*

author keywords: mouse pathology; rat pathology; gastrointestinal system; environmental toxicology; cell proliferation; carcinogenesis
MeSH headings : Administration, Oral; Animals; Chromium / toxicity; Drinking Water; Duodenal Neoplasms / chemically induced; Duodenal Neoplasms / epidemiology; Duodenal Neoplasms / pathology; Duodenum / drug effects; Duodenum / pathology; Environmental Exposure; Female; Male; Mice; Mice, Inbred Strains; Rats; Rats, Inbred F344; Toxicity Tests
Source: Web Of Science
Added: August 6, 2018

2016 article

The Strange, Expanding World of Animal Hepaciviruses

ANNUAL REVIEW OF VIROLOGY, VOL 3, Vol. 3, pp. 53–75.

By: A. Hartlage*, J. Cullen n & A. Kapoor*

author keywords: hepatitis C virus; pegivirus; hepegivirus; virome; virus evolution; animal models
MeSH headings : Animals; Cattle / virology; Chiroptera / virology; Colobus / virology; Flavivirus / classification; Flavivirus / genetics; GB virus A / classification; GB virus A / genetics; GB virus C / classification; GB virus C / genetics; Genetic Variation / genetics; Genome, Viral / genetics; Hepacivirus / classification; Hepacivirus / genetics; Hepatitis C / veterinary; Hepatitis C / virology; Horses / virology; Host Specificity; Humans; Pestivirus / classification; Pestivirus / genetics; Sharks / virology
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Association of Gallbladder Mucocele Histologic Diagnosis with Selected Drug Use in Dogs: A Matched Case-Control Study

JOURNAL OF VETERINARY INTERNAL MEDICINE, 29(6), 1464–1472.

By: J. Gookin n, M. Correa n, A. Peters n, A. Malueg n, K. Mathews n, J. Cullen n, G. Seiler n

author keywords: Bile; Canine; Mucus; Xenobiotic
MeSH headings : Animals; Case-Control Studies; Cholinergic Agents / adverse effects; Dog Diseases / chemically induced; Dogs; Female; Gallbladder Diseases / chemically induced; Gallbladder Diseases / veterinary; Hypothyroidism / drug therapy; Imidazoles / adverse effects; Male; Mucocele / chemically induced; Mucocele / pathology; Mucocele / veterinary; Neonicotinoids; Nitro Compounds / adverse effects; Pituitary ACTH Hypersecretion / drug therapy; Pituitary ACTH Hypersecretion / veterinary; Risk Factors; Thyroxine / adverse effects
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

Canine urothelial carcinoma: genomically aberrant and comparatively relevant

Chromosome Research, 23(2), 311–331.

By: S. Shapiro n, S. Raghunath n, C. Williams n, A. Motsinger-Reif n, J. Cullen n, T. Liu*, D. Albertson*, M. Ruvolo* ...

author keywords: Canine; Urothelial carcinoma; Transitional cell carcinoma; Cytogenetics; Chromosome aberration; Array comparative genomic hybridization; Comparative oncology
MeSH headings : Animals; Biopsy; Carcinoma / veterinary; Chromosome Aberrations; Comparative Genomic Hybridization; Computational Biology / methods; DNA Copy Number Variations; Dogs; Female; Genetic Loci; Genomics / methods; Humans; In Situ Hybridization, Fluorescence; Male; Urologic Neoplasms / veterinary
Sources: Crossref, Web Of Science
Added: August 6, 2018

2015 journal article

Clinical, histopathological and immunohistochemical characterization of a novel equine ocular disorder: heterochromic iridocyclitis with secondary keratitis in adult horses

VETERINARY OPHTHALMOLOGY, 18(6), 443–456.

By: N. Pinto n, R. McMullen n, K. Linder n, J. Cullen n & B. Gilger n

author keywords: endotheliitis; iridocyclitis; keratic precipitates; keratitis; retrocorneal membrane; uveitis
MeSH headings : Animals; Cornea / pathology; Female; Horse Diseases / diagnosis; Horse Diseases / pathology; Horses; Iridocyclitis / diagnosis; Iridocyclitis / pathology; Iridocyclitis / veterinary; Keratitis / diagnosis; Keratitis / pathology; Keratitis / veterinary; Male; Uvea / pathology
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

Effects of azathioprine, 6-mercaptopurine, and 6-thioguanine on canine primary hepatocytes

AMERICAN JOURNAL OF VETERINARY RESEARCH, 76(7), 649–655.

By: K. LaDuke, S. Ehling*, J. Cullen* & W. Baeumer

MeSH headings : Animals; Azathioprine / administration & dosage; Azathioprine / pharmacology; Cell Line; Cell Survival / drug effects; Dogs; Dose-Response Relationship, Drug; Hepatocytes / drug effects; Immunosuppressive Agents / administration & dosage; Immunosuppressive Agents / pharmacology; Mercaptopurine / administration & dosage; Mercaptopurine / pharmacology; Thioguanine / administration & dosage; Thioguanine / pharmacology
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Excess Secretion of Gel-Forming Mucins and Associated Innate Defense Proteins with Defective Mucin Un-Packaging Underpin Gallbladder Mucocele Formation in Dogs

PLOS ONE, 10(9).

MeSH headings : Animals; Dogs; Epithelial Cells / pathology; Epithelial Cells / ultrastructure; Epithelium / pathology; Exocytosis; Gallbladder / diagnostic imaging; Gallbladder / pathology; Gallbladder / surgery; Gallbladder / ultrastructure; Gels / metabolism; Glycosylation; Immunity, Innate; Immunoblotting; Male; Mass Spectrometry; Mucin 5AC / metabolism; Mucin-5B / metabolism; Mucocele / diagnostic imaging; Mucocele / pathology; Mucocele / surgery; Mucous Membrane / pathology; Mucus / metabolism; Phenotype; Rupture; Ultrasonography
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

Biliary Proliferative Lesions in the Sprague-Dawley Rat: Adverse/Non-adverse

TOXICOLOGIC PATHOLOGY, 42(5), 844–854.

By: J. Hailey*, J. Nold, R. Brown*, J. Cullen n, J. Holder*, H. Jordan*, D. Ennulat*, R. Miller*

author keywords: rat; biliary; oval cell; adverse; proliferative; bile duct; hyperplasia
MeSH headings : Animals; Bile Duct Neoplasms / pathology; Bile Ducts / cytology; Bile Ducts / metabolism; Bile Ducts / pathology; Biomarkers / metabolism; Cell Proliferation; Female; Hyperplasia / pathology; Male; Rats; Rats, Sprague-Dawley
Source: Web Of Science
Added: August 6, 2018

2014 personal communication

Effects of excess dietary fructose on liver pathology study have significant methodologic limitations: Reply

By: K. Kavanagh, A. Wylie, K. Tucker, T. Hamp, R. Gharaibeh, A. Fodor, J. Cullen

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Evaluation of fluorescence in situ hybridization for the detection of bacteria in feline inflammatory liver disease

JOURNAL OF FELINE MEDICINE AND SURGERY, 16(2), 109–117.

By: D. Twedt*, J. Cullen n, K. McCord, S. Janeczko*, J. Dudak* & K. Simpson*

MeSH headings : Animals; Bacteria / isolation & purification; Case-Control Studies; Cat Diseases / diagnosis; Cat Diseases / microbiology; Cats; Female; In Situ Hybridization, Fluorescence / methods; In Situ Hybridization, Fluorescence / veterinary; Inflammation / microbiology; Inflammation / veterinary; Liver / microbiology; Liver / pathology; Liver Diseases / microbiology; Liver Diseases / veterinary; Male; Retrospective Studies
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Hyperinsulinemic Hypoglycemia Syndrome in 2 Dogs with Bartonellosis

Journal of Veterinary Internal Medicine, 28(4), 1331–1335.

By: E. Breitschwerdt n, C. Goldkamp*, W. Castleman*, J. Cullen n, P. Mascarelli n, L. Thalhem n, M. Schaer*

author keywords: Dog; Hyperinsulinemia; Hypoglycemia; Monocytosis; Seizures
MeSH headings : Animals; Bartonella Infections / complications; Bartonella Infections / veterinary; Dog Diseases / microbiology; Dog Diseases / physiopathology; Dogs; Hyperinsulinism / etiology; Hyperinsulinism / veterinary; Hypoglycemia / etiology; Hypoglycemia / veterinary; Male; Syndrome
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2014 journal article

Lack of association of ABCB4 insertion mutation with gallbladder mucoceles in dogs

JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, 26(3), 434–436.

By: J. Cullen n, C. Willson n, J. Minch n, C. Kimbrough n & K. Mealey n

author keywords: ABCB4 gene; canine; gall bladder; mucocele
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Liver biomarker and in vitro assessment confirm the hepatic origin of aminotransferase elevations lacking histopathological correlate in beagle dogs treated with GABA(A) receptor antagonist NP260

TOXICOLOGY AND APPLIED PHARMACOLOGY, 277(2), 131–137.

By: A. Harrill*, J. Eaddy*, K. Rose*, J. Cullen n, L. Ramanathan, S. Wanaski*, S. Collins*, Y. Ho*, P. Watkins*, E. LeCluyse*

author keywords: Canine; Biomarker; Hepatotoxicity; Liver; Hepatic; miRNA; miR-122; GLDH; SDH
MeSH headings : Adenosine Triphosphate / metabolism; Alanine Transaminase / blood; Animals; Biomarkers / blood; Cells, Cultured; Chemical and Drug Induced Liver Injury / blood; Chemical and Drug Induced Liver Injury / diagnosis; Chemical and Drug Induced Liver Injury / etiology; Chemical and Drug Induced Liver Injury / genetics; Clinical Enzyme Tests; Dogs; Female; GABA-A Receptor Antagonists / toxicity; Genetic Markers; Glutamate Dehydrogenase / blood; Hepatocytes / drug effects; Hepatocytes / enzymology; Hepatocytes / pathology; Humans; L-Iditol 2-Dehydrogenase / blood; Liver / drug effects; Liver / enzymology; Liver / pathology; Male; MicroRNAs / blood; Necrosis; Predictive Value of Tests; Rats; Rats, Sprague-Dawley; Risk Assessment; Species Specificity; Sulfones / toxicity; Time Factors; Toxicity Tests / methods; meta-Aminobenzoates / toxicity
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Role of Pregnane X Receptor in Obesity and Glucose Homeostasis in Male Mice

JOURNAL OF BIOLOGICAL CHEMISTRY, 289(6), 3244–3261.

By: K. Spruiell*, R. Richardson*, J. Cullen n, E. Awumey*, F. Gonzalez* & M. Gyamfi*

author keywords: Diabetes; Metabolic Syndrome; Nuclear Receptors; Obesity; Peroxisome Proliferator-activated Receptor (PPAR)
MeSH headings : Adipose Tissue / metabolism; Adipose Tissue / pathology; Animals; Carnitine O-Palmitoyltransferase / genetics; Carnitine O-Palmitoyltransferase / metabolism; Diabetes Mellitus, Type 2 / genetics; Diabetes Mellitus, Type 2 / metabolism; Diabetes Mellitus, Type 2 / pathology; Female; Glucokinase / genetics; Glucokinase / metabolism; Glucose / genetics; Glucose / metabolism; Hepatomegaly / genetics; Hepatomegaly / metabolism; Hepatomegaly / pathology; Humans; Hyperinsulinism / genetics; Hyperinsulinism / metabolism; Hyperinsulinism / pathology; Liver / metabolism; Liver / pathology; Male; Mice; Mice, Knockout; Obesity / genetics; Obesity / metabolism; Obesity / pathology; PPAR alpha / genetics; PPAR alpha / metabolism; Pregnane X Receptor; Receptors, Steroid / genetics; Receptors, Steroid / metabolism; Species Specificity
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Role of human pregnane X receptor in high fat diet-induced obesity in pre-menopausal female mice

BIOCHEMICAL PHARMACOLOGY, 89(3), 399–412.

By: K. Spruiell*, D. Jones*, J. Cullen n, E. Awumey*, F. Gonzalez* & M. Gyamfi*

author keywords: Obesity; High-fat diet; Pregnane X receptor; Nuclear receptors; Type 2 diabetes; Females
MeSH headings : Adipose Tissue, White; Animals; Blood Glucose; Cytochrome P-450 CYP3A / genetics; Cytochrome P-450 CYP3A / metabolism; Dietary Fats / adverse effects; Female; Gene Expression Regulation; Glucose Intolerance; Humans; Ion Channels / genetics; Ion Channels / metabolism; Liver; Male; Membrane Proteins / genetics; Membrane Proteins / metabolism; Mice; Mice, Transgenic; Mitochondrial Proteins / genetics; Mitochondrial Proteins / metabolism; Obesity / drug therapy; Obesity / etiology; Pregnane X Receptor; Receptors, Steroid / genetics; Receptors, Steroid / metabolism; Uncoupling Protein 1
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Thymofibrolipoma in a Labrador Retriever

VETERINARY PATHOLOGY, 51(4), 816–819.

By: J. Tobias n & J. Cullen n

author keywords: dog; immunohistochemistry; thymoma; thymus gland
MeSH headings : Animals; Collagen / metabolism; Dog Diseases / pathology; Dog Diseases / surgery; Dogs; Epithelial Cells / pathology; Immunohistochemistry / veterinary; Lipoma / pathology; Lipoma / surgery; Lipoma / veterinary; Male; Neoplasms, Fibroepithelial / pathology; Neoplasms, Fibroepithelial / surgery; Neoplasms, Fibroepithelial / veterinary; North Carolina; Thymus Neoplasms / pathology; Thymus Neoplasms / surgery; Thymus Neoplasms / veterinary; Tomography, X-Ray Computed / veterinary
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Visualizing surface area and volume of lumens in three dimensions using images from histological sections

JOURNAL OF MICROSCOPY, 256(3), 190–196.

By: D. Livingston n, T. Tuong n, G. Kissling* & J. Cullen n

author keywords: 3-D reconstruction; histology; liver; negative space; portal tract
MeSH headings : Animals; Bile Ducts / cytology; Blood Vessels / cytology; Dogs; Imaging, Three-Dimensional / methods; Liver / cytology; Microscopy, Polarization / methods; Xylem / cytology
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Cardiac structure and function in female carrier's of a canine model of Duchenne muscular dystrophy

RESEARCH IN VETERINARY SCIENCE, 94(3), 610–617.

By: A. Kane n, T. DeFrancesco n, M. Boyle*, D. Malarkey*, J. Ritchey*, C. Atkins n, J. Cullen n, J. Kornegay*, B. Keene n

author keywords: Cardiomyopathy; Carrier; GRMD; Duchenne muscular dystrophy
MeSH headings : Animals; Disease Models, Animal; Dog Diseases / genetics; Dog Diseases / pathology; Dog Diseases / physiopathology; Dogs; Echocardiography / veterinary; Electrocardiography / veterinary; Electrocardiography, Ambulatory / veterinary; Female; Heart / physiopathology; Heterozygote; Muscular Dystrophy, Animal / genetics; Muscular Dystrophy, Animal / pathology; Muscular Dystrophy, Animal / physiopathology; Myocardium / pathology
Sources: Web Of Science, ORCID
Added: August 6, 2018

2013 journal article

Chikungunya Virus Host Range E2 Transmembrane Deletion Mutants Induce Protective Immunity against Challenge in C57BL/6J Mice

JOURNAL OF VIROLOGY, 87(12), 6748–6757.

By: A. Piper n, M. Ribeiro n, K. Smith*, C. Briggs*, E. Huitt*, K. Nanda*, C. Spears*, M. Quiles* ...

MeSH headings : Alphavirus Infections / immunology; Alphavirus Infections / prevention & control; Alphavirus Infections / virology; Animals; Antibodies, Neutralizing / blood; Antibodies, Viral / blood; Cell Line; Chikungunya Fever; Chikungunya virus / genetics; Chikungunya virus / immunology; Chikungunya virus / pathogenicity; Chikungunya virus / physiology; Host Specificity; Humans; Mice; Mice, Inbred C57BL; Mutation; Sequence Deletion; Vaccines, Attenuated / genetics; Vaccines, Attenuated / immunology; Viral Vaccines / genetics; Viral Vaccines / immunology; Virus Replication
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Dietary fructose induces endotoxemia and hepatic injury in calorically controlled primates

AMERICAN JOURNAL OF CLINICAL NUTRITION, 98(2), 349–357.

By: K. Kavanagh*, A. Wylie, K. Tucker, T. Hamp, R. Gharaibeh, A. Fodor, J. Cullen*

MeSH headings : Animal Feed / analysis; Animals; Diet, Fat-Restricted; Endotoxemia / chemically induced; Endotoxemia / pathology; Endpoint Determination; Energy Intake; Fatty Liver / chemically induced; Fatty Liver / pathology; Female; Fructose / adverse effects; Haplorhini; Liver / drug effects; Liver / microbiology; Liver / pathology; Male; Metagenome; Obesity / pathology; Weight Gain / drug effects
Source: Web Of Science
Added: August 6, 2018

2013 personal communication

From Bipeds to an Honorary Member of the American College of Veterinary Pathologists

Meuten, D. J., Law, J. M., Stromberg, P. C., & Cullen, J. M. (2013, May).

By: D. Meuten n, J. Law*, P. Stromberg & J. Cullen*

MeSH headings : Animals; Autopsy; Communication; Humans; Pathology, Veterinary / methods; Terminology as Topic
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Granulomatous metritis caused by suspected Dirofilaria immitis in a dog: a case report

VETERINARNI MEDICINA, 58(8), 437–441.

By: J. Park, A. Kim, E. Lee, E. Lee, D. Kwak, I. Hong, J. Cullen*, K. Jeong

author keywords: dog; filarid; granuloma; larva; nematode; uterus
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Necrolytic migratory erythema associated with a glucagon-producing primary hepatic neuroendocrine carcinoma in a cat

VETERINARY DERMATOLOGY, 24(4), 466–E110.

By: M. Asakawa n, J. Cullen n & K. Linder n

MeSH headings : Animals; Carcinoma, Neuroendocrine / complications; Carcinoma, Neuroendocrine / pathology; Carcinoma, Neuroendocrine / veterinary; Cat Diseases / etiology; Cat Diseases / pathology; Cats; Glucagon / metabolism; Liver Neoplasms / complications; Liver Neoplasms / pathology; Liver Neoplasms / veterinary; Male; Necrolytic Migratory Erythema / etiology; Necrolytic Migratory Erythema / pathology; Necrolytic Migratory Erythema / veterinary
Source: Web Of Science
Added: August 6, 2018

2013 personal communication

Primate fructose study misses mark due to preventable design flaws Reply

By: K. Kavanagh, A. Wylie, K. Tucker, T. Hamp, R. Gharaibeh, A. Fodor, J. Cullen

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Cutting Through to the Truth: Laser Capture Microscopy and Acute Toxic Biliary Injury

Journal of Comparative Pathology, 146(1), 45.

By: J. Cullen n

Source: Crossref
Added: December 29, 2020

2012 journal article

Evaluation of diode endoscopic cyclophotocoagulation in bovine cadaver eyes

AMERICAN JOURNAL OF VETERINARY RESEARCH, 73(9), 1445–1452.

By: J. Harrington n, R. McMullen, J. Cullen* & B. Gilger*

MeSH headings : Animals; Cadaver; Cattle; Cattle Diseases / pathology; Cattle Diseases / surgery; Endoscopy / methods; Endoscopy / veterinary; Glaucoma / pathology; Glaucoma / surgery; Glaucoma / veterinary; Histocytochemistry; Laser Coagulation / instrumentation; Laser Coagulation / methods; Laser Coagulation / veterinary
Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 journal article

Limited yield of diagnoses of intrahepatic infectious causes of canine granulomatous hepatitis from archival liver tissue

Journal of Veterinary Diagnostic Investigation, 24(5), 888–894.

By: R. Hutchins n, E. Breitschwerdt n, J. Cullen n, S. Bissett n & J. Gookin n

author keywords: Copper hepatopathy; dogs; fluorescent in situ hybridization; granulomatous hepatitis; polymerase chain reaction
MeSH headings : Animals; Bartonella / isolation & purification; Bartonella Infections / diagnosis; Bartonella Infections / microbiology; Bartonella Infections / pathology; Bartonella Infections / veterinary; Dog Diseases / diagnosis; Dog Diseases / pathology; Dogs; Female; Formaldehyde; Granuloma / pathology; Granuloma / veterinary; Hepatitis, Animal / diagnosis; Hepatitis, Animal / pathology; Liver / pathology; Male; Paraffin Embedding; Retrospective Studies; Tissue Preservation / veterinary
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2012 journal article

Reye's or Reye's-like syndrome in western lowland gorilla (Gorilla gorilla gorilla)

JOURNAL OF MEDICAL PRIMATOLOGY, 41(5), 329–331.

By: L. Minter n, J. Cullen n & M. Loomis*

author keywords: encephalopathy; Gorilla gorilla gorilla; hepatopathy; Reye's syndrome; western lowland gorilla
MeSH headings : Animals; Ape Diseases / blood; Ape Diseases / pathology; Fatal Outcome; Female; Gorilla gorilla; Kidney / pathology; Liver / pathology; Reye Syndrome / blood; Reye Syndrome / pathology; Reye Syndrome / veterinary
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Serology-Enabled Discovery of Genetically Diverse Hepaciviruses in a New Host

JOURNAL OF VIROLOGY, 86(11), 6171–6178.

By: P. Burbelo*, E. Dubovi*, P. Simmonds*, J. Medina*, J. Henriquez*, N. Mishra*, J. Wagner*, R. Tokarz* ...

MeSH headings : 5' Untranslated Regions; Animals; Antigens, Viral / genetics; Hepacivirus / genetics; Hepacivirus / immunology; Hepacivirus / pathogenicity; Hepatitis C / immunology; Hepatitis C / veterinary; Hepatitis C Antibodies / blood; Horse Diseases / virology; Horses; Host Specificity; Molecular Sequence Data; Nucleic Acid Conformation; RNA, Viral / genetics; Recombinant Proteins / genetics; Sequence Analysis, DNA
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Development of an Animal Model for Radiofrequency Ablation of Primary, Virally Induced Hepatocellular Carcinoma in the Woodchuck

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 22(11), 1613–1618.

By: C. Burke, J. Cullen*, A. State, S. Gadi*, K. Wilber, M. Rosenthal, A. Bulysheva, A. Pease, M. Mauro, H. Fuchs

MeSH headings : Animals; Biopsy; Carcinoma, Hepatocellular / pathology; Carcinoma, Hepatocellular / surgery; Carcinoma, Hepatocellular / virology; Catheter Ablation / instrumentation; Contrast Media; Equipment Design; Hepatitis B / complications; Hepatitis B / virology; Hepatitis B Virus, Woodchuck / pathogenicity; Liver Neoplasms, Experimental / pathology; Liver Neoplasms, Experimental / surgery; Liver Neoplasms, Experimental / virology; Magnetic Resonance Imaging; Marmota; Necrosis; Reproducibility of Results; Time Factors
Source: Web Of Science
Added: August 6, 2018

2011 journal article

H-ras Consensus Sequence and Mutations in Primary Hepatocellular Carcinomas of Lemurs and Lorises

VETERINARY PATHOLOGY, 48(4), 868–874.

By: J. Cullen n, C. Williams*, L. Zadrozny n, J. Otstot*, G. Solomon*, R. Sills*, H. Hong*

author keywords: liver; molecular biology; oncology; primate; zoo; hepatocellular carcinoma
MeSH headings : Animals; Carcinoma, Hepatocellular / genetics; Carcinoma, Hepatocellular / pathology; Carcinoma, Hepatocellular / veterinary; Consensus Sequence; Female; Gene Expression Regulation, Neoplastic; Genes, ras / genetics; Lemur; Liver Neoplasms / genetics; Liver Neoplasms / pathology; Liver Neoplasms / veterinary; Lorisidae; Male; Mutation; Primate Diseases / genetics; Primate Diseases / pathology
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Molecular cytogenetic characterization of canine histiocytic sarcoma: A spontaneous model for human histiocytic cancer identifies deletion of tumor suppressor genes and highlights influence of genetic background on tumor behavior

BMC Cancer, 11.

By: B. Hedan, R. Thomas, A. Motsinger-Reif, J. Abadie, C. Andre, J. Cullen, M. Breen

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Necropsy or Autopsy? It’s All About Communication!

Veterinary Pathology, 49(2), 271–272.

By: M. Law n, P. Stromberg*, D. Meuten n & J. Cullen n

MeSH headings : Animals; Autopsy; Communication; Humans; Pathology, Veterinary / methods; Terminology as Topic
Sources: Web Of Science, Crossref
Added: August 6, 2018

2011 journal article

Recommended guidelines for submission, trimming, margin evaluation, and reporting of tumor biopsy specimens in veterinary surgical pathology

Veterinary Pathology, 48(1), 19–31.

By: D. Kamstock, E. Ehrhart, D. Getzy, N. Bacon, K. Rassnick, S. Moroff, S. Liu, R. Straw ...

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Recommended guidelines for the conduct and evaluation of prognostic studies in veterinary oncology

Veterinary Pathology, 48(1), 7–18.

By: J. Webster, M. Dennis, N. Dervisis, J. Heller, N. Bacon, P. Bergman, D. Bienzle, G. Cassali ...

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Acute ANIT Toxicity in Male IL-10 Knockout and Wild-type Mice

TOXICOLOGIC PATHOLOGY, 38(5), 745–755.

By: B. Faiola*, R. Peterson*, C. Kimbrough*, H. Jordan* & J. Cullen n

author keywords: animal models; toxicologic pathology; hepatobiliary system; histopathology; knockout mouse; liver; mouse pathology
MeSH headings : Animals; Chemical and Drug Induced Liver Injury / genetics; Chemical and Drug Induced Liver Injury / metabolism; Chemical and Drug Induced Liver Injury / pathology; Gallbladder / drug effects; Gallbladder / pathology; Immunohistochemistry; Interleukin-10 / genetics; Isothiocyanates / toxicity; Male; Mice; Mice, Inbred C57BL; Mice, Knockout
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Congenital Hepatic Fibrosis in 5 Dogs

VETERINARY PATHOLOGY, 47(1), 102–107.

By: D. Brown n, T. Van Winkle*, T. Cecere n, S. Rushton*, C. Brachelente* & J. Cullen n

author keywords: bile ducts; biliary tract diseases; canine; embryonic development; liver
MeSH headings : Animals; Bile Ducts / pathology; Dog Diseases / congenital; Dog Diseases / pathology; Dogs; Female; Liver / pathology; Liver Cirrhosis / congenital; Liver Cirrhosis / pathology; Liver Cirrhosis / veterinary; Male; Proliferating Cell Nuclear Antigen / metabolism
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Imaging diagnosis-neuronal ceroid lipofuscinosis with a chronic subdural hematoma

Veterinary Radiology & Ultrasound, 51(2), 155–158.

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Spontaneous Hepatocellular Carcinoma in Captive Prosimians

VETERINARY PATHOLOGY, 47(2), 306–311.

By: L. Zadrozny n, C. Williams*, A. Remick & J. Cullen n

author keywords: Hepadnaviridae; hepatocellular carcinoma; iron; lemur; liver cell adenoma; neoplasms; prosimians
MeSH headings : Animals; Carcinoma, Hepatocellular / epidemiology; Carcinoma, Hepatocellular / pathology; Carcinoma, Hepatocellular / veterinary; Female; Histocytochemistry / veterinary; Incidence; Lemur; Liver Neoplasms / epidemiology; Liver Neoplasms / pathology; Liver Neoplasms / veterinary; Male; Monkey Diseases / epidemiology; Monkey Diseases / pathology; Retrospective Studies
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Time Course Gene Expression Using Laser Capture Microscopy-Extracted Bile Ducts, but Not Hepatic Parenchyma, Reveals Acute Alpha-Naphthylisothiocyanate Toxicity

TOXICOLOGIC PATHOLOGY, 38(5), 715–729.

By: J. Cullen n, J. Falls*, H. Brown*, L. Yoon*, N. Cariello*, B. Faiola*, C. Kimbrough*, H. Jordan*, R. Miller*

author keywords: bioinformatics; apoptosis/cell death; biotechnology; genomics; hepatobiliary system; histopathology; toxicity
MeSH headings : 1-Naphthylisothiocyanate / toxicity; Animals; Bile Ducts / drug effects; Gene Expression / drug effects; Gene Expression Profiling; Liver / drug effects; Male; Microscopy, Confocal; Oligonucleotide Array Sequence Analysis; Rats; Rats, Sprague-Dawley; Time; Unfolded Protein Response / drug effects
Source: Web Of Science
Added: August 6, 2018

2009 journal article

ACQUIRED ARTERIOVENOUS FISTULA IN A GRIZZLY BEAR (URSUS ARCTOS HORRIBILIS)

JOURNAL OF ZOO AND WILDLIFE MEDICINE, 40(1), 193–195.

By: A. Tuttle*, R. MacLean, K. Linder*, J. Cullen*, B. Wolfe & M. Loomis

author keywords: Acquired arteriovenous fistula; grizzly bear; Ursus arctos horribilis; trauma; wound
MeSH headings : Animals; Arteriovenous Fistula / diagnosis; Arteriovenous Fistula / surgery; Arteriovenous Fistula / veterinary; Male; Treatment Outcome; Ursidae; Wounds and Injuries / complications; Wounds and Injuries / veterinary
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Aflatoxin B1 and/or Hepatitis B Virus Induced Tumor Spectrum in a Genetically Engineered Hepatitis B Virus Expression and Trp53 Haploinsufficient Mouse Model System for Hepatocarcinogenesis

TOXICOLOGIC PATHOLOGY, 37(3), 333–342.

By: J. Cullen n, D. Brown n, G. Kissling*, J. Foley*, J. Rizzo n, P. Marion*, V. Parron*, J. French*

author keywords: aflatoxin B-1; hepatitis B virus; hepatocellular carcinoma; p53; transgenic; Trp53; tumorigenesis; FVB/N strain
MeSH headings : Aflatoxin B1 / genetics; Animals; Disease Models, Animal; Female; Genetic Engineering / adverse effects; Hepatitis B Surface Antigens / genetics; Hepatitis B virus / genetics; Immunohistochemistry; Kaplan-Meier Estimate; Ki-67 Antigen / genetics; Liver Neoplasms, Experimental / chemically induced; Liver Neoplasms, Experimental / genetics; Liver Neoplasms, Experimental / pathology; Liver Neoplasms, Experimental / virology; Male; Mice; Mice, Inbred Strains; Mice, Transgenic; Sex Factors; Survival Analysis; Tumor Suppressor Protein p53 / genetics
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Microarray-based cytogenetic profiling reveals recurrent and subtype-associated genomic copy number aberrations in feline sarcomas

CHROMOSOME RESEARCH, 17(8), 987–1000.

By: R. Thomas n, V. Valli*, P. Ellis*, J. Bell*, E. Karlsson*, J. Cullen n, K. Lindblad-Toh*, C. Langford*, M. Breen n

author keywords: microarray; comparative genomic hybridization (CGH); feline; sarcoma; chromosome
MeSH headings : Animals; Cat Diseases / diagnosis; Cats; Cytogenetic Analysis; DNA Copy Number Variations; Gene Dosage; Gene Expression Profiling; Injections / adverse effects; Oligonucleotide Array Sequence Analysis; Sarcoma / diagnosis; Sarcoma / genetics; Sarcoma / veterinary
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Summary of the World Small Animal Veterinary Association Standardization Committee Guide to Classification of Liver Disease in Dogs and Cats

VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE, 39(3), 395-+.

By: J. Cullen n

author keywords: Pathology; Histopathology; Liver; Classification; Dog; Cat
MeSH headings : Animals; Cat Diseases / classification; Cat Diseases / microbiology; Cat Diseases / pathology; Cats; Dog Diseases / classification; Dog Diseases / microbiology; Dog Diseases / pathology; Dogs; Interprofessional Relations; Liver Diseases / classification; Liver Diseases / microbiology; Liver Diseases / pathology; Liver Diseases / veterinary; Societies; Terminology as Topic
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Expression of CDK4 or CDK2 in mouse oral cavity is retained in adult pituitary with distinct effects on tumorigenesis

CANCER RESEARCH, 68(1), 162–171.

By: E. Macias n, P. Marva*, A. Senderowicz*, J. Cullen n & M. Rodriguez-Puebla n

MeSH headings : Animals; Cell Count; Cell Transformation, Neoplastic / genetics; Cell Transformation, Neoplastic / metabolism; Cyclin-Dependent Kinase 2 / analysis; Cyclin-Dependent Kinase 2 / genetics; Cyclin-Dependent Kinase 2 / metabolism; Cyclin-Dependent Kinase 4 / analysis; Cyclin-Dependent Kinase 4 / genetics; Cyclin-Dependent Kinase 4 / metabolism; Cyclin-Dependent Kinase Inhibitor p27 / genetics; Cyclin-Dependent Kinase Inhibitor p27 / metabolism; Humans; Mice; Mice, Transgenic; Mouth / embryology; Mouth / enzymology; Pituitary Gland / enzymology; Pituitary Neoplasms / enzymology; Pituitary Neoplasms / genetics; Promoter Regions, Genetic; Stem Cells
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Harderian gland neoplasms in captive, wild-caught Beechey ground squirrels (Spermophilus beecheyi)

VETERINARY PATHOLOGY, 45(3), 388–392.

By: R. Ranck n, J. Cullen n, K. Waggie* & P. Marion*

author keywords: carcinoma; ground squirrel hepatitis virus; ground squirrels; Harderian gland; Sciuridae
MeSH headings : Adenocarcinoma / pathology; Adenocarcinoma / veterinary; Animals; Animals, Wild; Eye Neoplasms / pathology; Eye Neoplasms / veterinary; Female; Functional Laterality; Harderian Gland / pathology; Male; Neoplasms / pathology; Neoplasms / veterinary; Sciuridae
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Serologic survey of woodchuck hepatitis virus in North Carolina woodchucks (Marmota monax)

JOURNAL OF ZOO AND WILDLIFE MEDICINE, 39(2), 263–265.

By: J. Cullen n, D. Lindsey-Pegram & P. Cote

author keywords: hepadnavirus; woodchuck; woodchuck hepatitis virus
MeSH headings : Animals; Antibodies, Viral / blood; Female; Hepatitis Viruses / immunology; Hepatitis, Viral, Animal / epidemiology; Male; Marmota / virology; Rodent Diseases / epidemiology; Seroepidemiologic Studies; United States / epidemiology
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Selective deletion of antigen-specific CD8(+) T cells by MHC class I tetramers, coupled to the type I ribosome-inactivating protein saporin

BLOOD, 109(8), 3300–3307.

By: P. Hess n, C. Barnes*, M. Woolard*, M. Johnson*, J. Cullen n, E. Collins*, J. Frelinger*

MeSH headings : Animals; Autoimmune Diseases / drug therapy; Autoimmune Diseases / immunology; Autoimmune Diseases / pathology; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / pathology; Cell Death / drug effects; Clonal Deletion / drug effects; Cytotoxins / immunology; Cytotoxins / pharmacology; Histocompatibility Antigens Class I / immunology; Histocompatibility Antigens Class I / pharmacology; Mice; Mice, Transgenic; N-Glycosyl Hydrolases / pharmacology; Plant Proteins / pharmacology; Ribosome Inactivating Proteins, Type 1; Saporins; Time Factors; Transplantation, Homologous
Sources: Web Of Science, ORCID
Added: August 6, 2018

2007 journal article

The liver of woodchucks chronically infected with the woodchuck hepatitis virus contains foci of virus core antigen-negative hepatocytes with both altered and normal morphology

VIROLOGY, 359(2), 283–294.

By: C. Xu, T. Yamamoto, T. Zhou, C. Aldrich, K. Frank, J. Cullen*, A. Jilbert, W. Mason

author keywords: foci of altered hepatocytes; Woodchuck hepatitis virus; WHV; hepatocellular carcinoma
MeSH headings : Animals; Cell Line, Tumor; Fetuin-B; Gene Expression Regulation, Viral; Hepatitis B Core Antigens / metabolism; Hepatitis B Virus, Woodchuck / physiology; Hepatitis B, Chronic / pathology; Hepatitis B, Chronic / virology; Hepatocytes / cytology; Hepatocytes / pathology; Hepatocytes / virology; Humans; Marmota / virology; RNA, Messenger / genetics; RNA, Messenger / metabolism; alpha-Fetoproteins / metabolism
Source: Web Of Science
Added: August 6, 2018

2006 article

Fall panicum (Panicum dichotomiflorum) hepatotoxicosis in horses and sheep

JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 20, pp. 1414–1421.

By: A. Johnson, T. Divers, M. Freckleton, H. McKenzie, E. Mitchell, J. Cullen*, S. McDonough

author keywords: apoptosis; hepatocyte necrosis; liver; steroidal saponins
Source: Web Of Science
Added: August 6, 2018

2006 journal article

P.050 Appearance of core antigen negative hepatocytes in woodchucks chronically infected with woodchuck hepatitis virus

Journal of Clinical Virology, 36, S76.

By: C. Xu, T. Yamamoto, T. Zhou, C. Aldrich, J. Cullen*, A. Jilbert, W. Mason

Source: Crossref
Added: August 28, 2020

2006 review

The role of pathology in the identification of drug-induced hepatic toxicity

[Review of ]. EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 2(2), 241–247.

By: J. Cullen n & R. Miller*

author keywords: drug-induced toxicity; liver; pathology; safety assessment; toxicology
MeSH headings : Animals; Chemical and Drug Induced Liver Injury / diagnosis; Chemical and Drug Induced Liver Injury / etiology; Drug Evaluation, Preclinical / methods; Drug Industry / methods; Humans; Liver / pathology; Pathology, Clinical / education; Pathology, Clinical / methods
Source: Web Of Science
Added: August 6, 2018

2005 journal article

CDNA microarray analysis of HBV transgenic mouse liver identifies genes in lipid biosynthetic and growth control pathways affected by HBV

JOURNAL OF MEDICAL VIROLOGY, 77(1), 57–65.

By: M. Hajjou*, R. Norel*, R. Carver*, P. Marion*, J. Cullen n, L. Rogler*, C. Rogler*

author keywords: gene expression; molecular virology; host-pathogen interaction
MeSH headings : Animals; DNA, Complementary / analysis; Disease Models, Animal; Hepatitis B / genetics; Hepatitis B / immunology; Hepatitis B / virology; Hepatitis B virus / genetics; Hepatitis B virus / immunology; Hepatitis B virus / pathogenicity; Hepatitis B virus / physiology; Lipids / biosynthesis; Liver / metabolism; Liver / virology; Mice; Mice, Transgenic; Oligonucleotide Array Sequence Analysis
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Mechanistic Classification of Liver Injury

Toxicologic Pathology, 33(1), 6–8.

By: J. Cullen n

author keywords: liver toxicity hepatocyte; cholestasis; apoptosis; autoimmunity; mitochondrial toxicity; cytochrome p450
MeSH headings : Acetaminophen / adverse effects; Analgesics, Non-Narcotic / adverse effects; Animals; Apoptosis / drug effects; Autoimmunity / drug effects; Calcium / metabolism; Chemical and Drug Induced Liver Injury, Chronic / classification; Chemical and Drug Induced Liver Injury, Chronic / metabolism; Chemical and Drug Induced Liver Injury, Chronic / pathology; Cytochrome P-450 Enzyme System / drug effects; Hepatocytes / drug effects; Hepatocytes / pathology; Humans; Liver Diseases / classification; Liver Diseases / metabolism; Liver Diseases / pathology; Mitochondria / drug effects
Sources: Crossref, NC State University Libraries
Added: August 6, 2018

2005 journal article

Paraneoplastic pemphigus in a dog with splenic sarcoma

VETERINARY PATHOLOGY, 42(1), 88–91.

By: S. Elmore*, J. Basseches, G. Anhalt, J. Cullen* & T. Olivry n

author keywords: autoantibodies; autoimmunity; blistering skin disease; canine; erythema multiforme; immunoblotting; immunofluorescence; immunoprecipitation; neoplasia; pemphigus; skin; spleen
MeSH headings : Animals; Autoantibodies / blood; Dog Diseases / pathology; Dogs; Fatal Outcome; Histocytochemistry / veterinary; Immunoprecipitation / veterinary; Male; Pemphigus / complications; Pemphigus / pathology; Pemphigus / veterinary; Sarcoma / complications; Sarcoma / pathology; Sarcoma / surgery; Sarcoma / veterinary; Splenectomy / veterinary; Splenic Neoplasms / complications; Splenic Neoplasms / pathology; Splenic Neoplasms / surgery; Splenic Neoplasms / veterinary
Sources: Web Of Science, ORCID
Added: August 6, 2018

2004 journal article

Adenovirus-based gene therapy during clevudine treatment of woodchucks chronically infected with woodchuck hepatitis virus

VIROLOGY, 327(1), 26–40.

By: Y. Zhu*, J. Cullen n, C. Aldrich*, J. Saputelli*, D. Miller*, C. Seeger*, W. Mason*, A. Jilbert*

author keywords: hepatitis B virus; clevudine; IFN-alpha
MeSH headings : Adenoviridae / genetics; Adenoviridae / pathogenicity; Animals; Antiviral Agents / administration & dosage; Antiviral Agents / therapeutic use; Arabinofuranosyluracil / administration & dosage; Arabinofuranosyluracil / analogs & derivatives; Arabinofuranosyluracil / therapeutic use; Baculoviridae / genetics; Baculoviridae / metabolism; Cell Line; Combined Modality Therapy; Genetic Therapy; Hepatitis B Virus, Woodchuck / drug effects; Hepatitis B Virus, Woodchuck / genetics; Hepatitis B Virus, Woodchuck / physiology; Hepatitis B, Chronic / drug therapy; Hepatitis B, Chronic / immunology; Hepatitis B, Chronic / therapy; Interferon-gamma / genetics; Interferon-gamma / immunology; Marmota; Treatment Outcome; Tumor Necrosis Factor-alpha / genetics; Tumor Necrosis Factor-alpha / immunology; beta-Galactosidase / genetics
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Woodchuck interleukin-6 gene: structure,characterization, and biologic activity

GENE, 342(1), 157–164.

By: D. Li*, A. Kumanogoh*, T. Cao*, . Parnes* & J. Cullen n

author keywords: interleukin-6; woodchuck hepatitis virus; human hepatitis B virus
MeSH headings : Animals; Base Sequence; Binding Sites / genetics; Cell Division / drug effects; Cell Line, Tumor; DNA, Complementary / chemistry; DNA, Complementary / genetics; DNA, Complementary / isolation & purification; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Exons; Genes / genetics; Humans; Interleukin-6 / genetics; Interleukin-6 / metabolism; Interleukin-6 / pharmacology; Introns; Marmota / genetics; Marmota / metabolism; Molecular Sequence Data; Promoter Regions, Genetic / genetics; Recombinant Proteins / metabolism; Recombinant Proteins / pharmacology; Sequence Alignment; Sequence Analysis, DNA; Sequence Homology, Nucleic Acid; Transcription Factors / metabolism
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Detection of Bartonella henselae and Bartonella clarridgeiae DNA in hepatic specimens from two dogs with hepatic disease

Journal of the American Veterinary Medical Association, 222(1), 47–51.

By: T. Gillespie*, R. Washabau*, M. Goldschmidt*, J. Cullen n, A. Rogala n & E. Breitschwerdt n

MeSH headings : Animals; Bartonella / genetics; Bartonella / isolation & purification; Bartonella Infections / diagnosis; Bartonella Infections / microbiology; Bartonella Infections / pathology; Bartonella Infections / veterinary; Bartonella henselae / genetics; Bartonella henselae / isolation & purification; DNA, Bacterial / analysis; Dog Diseases / diagnosis; Dog Diseases / microbiology; Dog Diseases / pathology; Dogs; Female; Liver / microbiology; Liver / pathology; Liver Diseases / diagnosis; Liver Diseases / microbiology; Liver Diseases / pathology; Liver Diseases / veterinary; Polymerase Chain Reaction / veterinary
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2002 journal article

Helicobacter marmotae sp nov isolated from livers of woodchucks and intestines of cats

JOURNAL OF CLINICAL MICROBIOLOGY, 40(7), 2513–2519.

By: J. Fox*, Z. Shen*, S. Xu*, Y. Feng*, C. Dangler*, F. Dewhirst, B. Paster, J. Cullen n

MeSH headings : Animals; Base Sequence; Cats / microbiology; Cocarcinogenesis; DNA, Bacterial / genetics; Disease Models, Animal; Helicobacter / classification; Helicobacter / genetics; Helicobacter / isolation & purification; Helicobacter / pathogenicity; Hepatitis B / etiology; Hepatitis B Virus, Woodchuck / isolation & purification; Hepatitis B Virus, Woodchuck / pathogenicity; Humans; Liver / microbiology; Liver / pathology; Liver / virology; Liver Neoplasms, Experimental / etiology; Marmota / microbiology; Mice; Microscopy, Electron; Molecular Sequence Data; Phylogeny; RNA, Bacterial / genetics; RNA, Ribosomal, 16S / genetics; Species Specificity
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Antiviral efficacy and pharmacokinetics of oral adefovir dipivoxil in chronically woodchuck hepatitis virus-infected woodchucks

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 45(10), 2740–2745.

By: J. Cullen n, D. Ll, C. Brown n, E. Eisenberg*, K. Cundy*, J. Wolfe*, J. Toole*, C. Gibbs*

MeSH headings : Adenine / analogs & derivatives; Adenine / pharmacokinetics; Adenine / therapeutic use; Administration, Oral; Animals; Chemistry, Clinical; Chronic Disease; DNA, Viral / blood; Disease Models, Animal; Hepatitis B / blood; Hepatitis B / drug therapy; Hepatitis B / metabolism; Hepatitis B Virus, Woodchuck / drug effects; Liver / drug effects; Liver / pathology; Marmota; Organophosphonates; Treatment Outcome
Source: Web Of Science
Added: August 6, 2018

2001 article

Idiopathic noncirrhotic portal hypertension in dogs: 33 cases (1982-1998)

Bunch, S. E., Johnson, S. E., & Cullen, J. M. (2001, February 1). JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 218, pp. 392–399.

By: S. Bunch n, S. Johnson & J. Cullen*

MeSH headings : Alanine Transaminase / blood; Alkaline Phosphatase / blood; Animals; Ascites / veterinary; Biopsy / veterinary; Blood Chemical Analysis / veterinary; Diarrhea / veterinary; Dog Diseases / diagnostic imaging; Dog Diseases / pathology; Dog Diseases / therapy; Dogs; Exudates and Transudates; Female; Histocytochemistry / veterinary; Hypertension, Portal / diagnostic imaging; Hypertension, Portal / pathology; Hypertension, Portal / therapy; Hypertension, Portal / veterinary; Liver / diagnostic imaging; Liver / pathology; Male; Portacaval Shunt, Surgical / veterinary; Radiography; Retrospective Studies; Treatment Outcome; Ultrasonography; Urinalysis / veterinary; Vomiting / veterinary
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Kinetics of hepadnavirus loss from the liver during inhibition of viral DNA synthesis

JOURNAL OF VIROLOGY, 75(1), 311–322.

By: Y. Zhu*, T. Yamamoto*, J. Cullen n, J. Saputelli*, C. Aldrich*, D. Miller*, S. Litwin*, P. Furman*, A. Jilbert*, W. Mason*

MeSH headings : Amino Acid Sequence; Animals; Antiviral Agents / pharmacology; Arabinofuranosyluracil / analogs & derivatives; Arabinofuranosyluracil / pharmacology; DNA, Circular / analysis; DNA, Viral / analysis; DNA, Viral / biosynthesis; Drug Resistance; Hepatitis B Virus, Woodchuck / drug effects; Hepatitis B Virus, Woodchuck / genetics; Hepatocytes / virology; Kinetics; Lamivudine / pharmacology; Marmota; Molecular Sequence Data
Source: Web Of Science
Added: August 6, 2018

2001 journal article

T-helper cell response to woodchuck hepatitis virus antigens after therapeutic vaccination of chronically-infected animals treated with lamivudine

JOURNAL OF HEPATOLOGY, 35(1), 105–111.

author keywords: woodchuck hepatitis virus; lamivudine; Th1/Th2; therapeutic vaccination
MeSH headings : Animals; Antigens, Viral / immunology; Chronic Disease; Hepatitis B / immunology; Hepatitis B / therapy; Hepatitis B / virology; Hepatitis B Virus, Woodchuck / drug effects; Hepatitis B Virus, Woodchuck / immunology; Immunotherapy, Active; Lamivudine / therapeutic use; Liver / drug effects; Liver / pathology; Marmota; Reverse Transcriptase Inhibitors / therapeutic use; T-Lymphocytes, Helper-Inducer / immunology; Viral Load; Viremia / virology
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Sustained survival of human hepatocytes in mice: A model for in vivo infection with human hepatitis B and hepatitis delta viruses

Nature Medicine, 6(3), 327–331.

By: K. Ohashi*, P. Marion*, H. Nakai*, L. Meuse*, J. Cullen n, B. Bordier*, R. Schwall*, H. Greenberg*, J. Glenn*, M. Kay*

MeSH headings : Animals; Cell Transplantation; Disease Models, Animal; Hepatitis B / pathology; Hepatitis B / transmission; Hepatitis B virus / isolation & purification; Hepatitis D / pathology; Hepatitis D / transmission; Hepatitis Delta Virus / isolation & purification; Humans; Liver / cytology; Liver / pathology; Liver / virology; Mice; Mice, Inbred NOD; Mice, SCID; Proto-Oncogene Proteins c-met / immunology; Time Factors; Transplantation, Heterologous
Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Woodchuck lymphotoxin-alpha, -beta and tumor necrosis factor genes: structure, characterization and biological activity

GENE, 242(1-2), 295–305.

By: D. Li n, E. Havell n, C. Brown n & J. Cullen n

author keywords: cDNA; cytotoxicity; gene; LT; TNF; transcription factor binding site
MeSH headings : Animals; Base Sequence; Binding Sites; Cell Line; DNA / chemistry; DNA / genetics; DNA / metabolism; DNA, Complementary / chemistry; DNA, Complementary / genetics; DNA, Complementary / isolation & purification; Exons; Gene Expression; Genes / genetics; Glutathione Transferase / genetics; Glutathione Transferase / metabolism; Humans; Introns; Lymphotoxin-alpha / genetics; Lymphotoxin-alpha / metabolism; Lymphotoxin-alpha / pharmacology; Lymphotoxin-beta; Marmota / genetics; Membrane Proteins / genetics; Membrane Proteins / metabolism; Molecular Sequence Data; Polymorphism, Genetic; Promoter Regions, Genetic; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / metabolism; Recombinant Fusion Proteins / pharmacology; Sequence Analysis, DNA; Sequence Homology, Nucleic Acid; Transcription Factors / metabolism; Tumor Cells, Cultured / cytology; Tumor Cells, Cultured / drug effects; Tumor Necrosis Factor-alpha / genetics; Tumor Necrosis Factor-alpha / metabolism; Tumor Necrosis Factor-alpha / pharmacology
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Hydranencephaly and cerebellar hypoplasia in two kittens attributed to intrauterine parvovirus infection

JOURNAL OF COMPARATIVE PATHOLOGY, 121(1), 39–53.

By: N. Sharp n, B. Davis*, J. Guy n, J. Cullen n, S. Steingold n & J. Kornegay*

MeSH headings : Animals; Brain / abnormalities; Brain / virology; Cat Diseases / pathology; Cat Diseases / virology; Cats; Cerebellum / pathology; Cerebellum / virology; Cytopathogenic Effect, Viral; Female; Hydranencephaly / pathology; Hydranencephaly / veterinary; Hydranencephaly / virology; Parvoviridae Infections / complications; Parvoviridae Infections / pathology; Parvoviridae Infections / veterinary; Parvovirus; Polymerase Chain Reaction / veterinary; Pregnancy; Vaccines, Attenuated / administration & dosage; Vaccines, Attenuated / adverse effects; Viral Vaccines / administration & dosage; Viral Vaccines / adverse effects
Sources: Web Of Science, ORCID
Added: August 6, 2018

1998 journal article

Lamivudine therapy of WHV-infected woodchucks

VIROLOGY, 245(1), 18–32.

By: W. Mason*, J. Cullen n, G. Moraleda*, J. Saputelli*, C. Aldrich*, D. Miller*, B. Tennant*, L. Frick* ...

MeSH headings : Amino Acid Sequence; Animals; DNA Replication / drug effects; DNA, Viral / drug effects; DNA, Viral / genetics; Hepatitis B virus / isolation & purification; Hepatitis B virus / physiology; Hepatitis B, Chronic / drug therapy; Lamivudine / therapeutic use; Marmota; Molecular Sequence Data; Reverse Transcriptase Inhibitors / therapeutic use; Virus Replication / drug effects
Source: Web Of Science
Added: August 6, 2018

1997 journal article

In vivo antiviral activity and pharmacokinetics of (-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine in woodchuck hepatitis virus-infected woodchucks

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 41(10), 2076–2082.

By: J. Cullen n, S. Smith n, M. Davis n, S. Dunn n, C. Botteron n, A. Cecchi n, D. Linsey n, D. Linzey n ...

MeSH headings : Animals; Antiviral Agents / pharmacokinetics; Antiviral Agents / therapeutic use; DNA, Viral / analysis; DNA, Viral / biosynthesis; Emtricitabine / analogs & derivatives; Half-Life; Hepatitis B / drug therapy; Hepatitis B / virology; Hepatitis B Virus, Woodchuck; Liver / cytology; Liver / metabolism; Liver / virology; Marmota / virology; Stereoisomerism; Zalcitabine / analogs & derivatives; Zalcitabine / pharmacokinetics; Zalcitabine / therapeutic use
Source: Web Of Science
Added: August 6, 2018

1997 journal article

Therapeutic vaccination of woodchucks against chronic woodchuck hepatitis virus infection

JOURNAL OF HEPATOLOGY, 27(4), 726–737.

author keywords: antibodies; hepatitis; immune therapy; peptides; T-cell help; vaccination; woodchuck; woodchuck hepatitis virus (WHV); woodchuck hepatitis virus surface antigen (WHsAg)
MeSH headings : Amino Acid Sequence; Animals; Biopsy; Chronic Disease; Disease Models, Animal; Hepatitis B / pathology; Hepatitis B / prevention & control; Hepatitis B Vaccines; Liver / pathology; Marmota / immunology; Molecular Sequence Data; Rodent Diseases / prevention & control
Source: Web Of Science
Added: August 6, 2018

1993 journal article

HISTOLOGIC CHARACTERIZATION OF HEPATIC CARCINOGENESIS IN TRANSGENIC MICE EXPRESSING SV40 T-ANTIGENS

VETERINARY PATHOLOGY, 30(2), 111–118.

author keywords: LIVER; NEOPLASIA; ONCOGENE; SIMIAN VIRUS-40; T-ANTIGENS; TRANSGENIC MICE
MeSH headings : Adenoma, Bile Duct / pathology; Animals; Antigens, Polyomavirus Transforming / genetics; Antigens, Viral, Tumor / genetics; Bile Duct Neoplasms / pathology; Bile Ducts, Intrahepatic / pathology; Female; Gene Expression Regulation, Neoplastic; Liver / pathology; Liver / ultrastructure; Liver Neoplasms / immunology; Liver Neoplasms / pathology; Liver Neoplasms, Experimental / pathology; Male; Mice; Mice, Transgenic; Organ Size; Time Factors
Source: Web Of Science
Added: August 6, 2018

1990 journal article

Hepatic neoplasms in aflatoxin B1-treated, congenital duck hepatitis B virus-infected, and virus-free Pekin ducks

Cancer Research, 50(13), 4072.

By: J. Cullen, P. Marion, G. Sherman, X. Hong & J. Newbold

Source: NC State University Libraries
Added: August 6, 2018

1987 journal article

Pathologic manifestations of experimental Babesia microti infection in hamsters

Laboratory Animal Science, 37, 640–643.

By: J. Cullen & J. Levine

Source: NC State University Libraries
Added: August 6, 2018

journal article

The MTAP-CDKN2A locus confers susceptibility to a naturally occurring canine cancer

Shearin, A. L., Hedan, B., Cadieu, E., Erich, S. A., Schmidt, E. V., Faden, D. L., … Andre, C. Cancer Epidemiology Biomarkers, 21(7), 1019–1027.

By: A. Shearin, B. Hedan, E. Cadieu, S. Erich, E. Schmidt, D. Faden, J. Cullen, J. Abadie ...

Source: NC State University Libraries
Added: August 6, 2018