Works (109)

2023 article

Assessment of the mode of action underlying development of liver lesions in mice following oral exposure to HFPO-DA and relevance to humans

Heintz, M. M., Haws, L. C., Klaunig, J. E., Cullen, J. M., & Thompson, C. M. (2023, January 11). TOXICOLOGICAL SCIENCES.

By: M. Heintz*, L. Haws*, J. Klaunig*, J. Cullen & C. Thompson*

author keywords: mode of action (MOA); liver; peroxisome proliferator-activated receptor alpha; (PPAR alpha); HFPO-DA (GenX); PFAS
Source: Web Of Science
Added: February 27, 2023

2023 article

Patent hepatic ciliated foregut remnant resulting in an umbilicobiliary sinus tract, with gallbladder agenesis, in an 8-wk-old male French Bulldog

Wong, H. E., Cullen, J. M., Vila-Gonzalez, M., Pittaway, R., Desmet, V. J., & Gillian, T. D. (2023, January 4). JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION.

By: H. Wong*, J. Cullen, M. Vila-Gonzalez*, R. Pittaway*, V. Desmet* & T. Gillian*

author keywords: agenesis; cilia; cysts; dogs; embryonic structures; foregut remnant; fluorescent antibody technique; gallbladder; liver
Source: Web Of Science
Added: January 23, 2023

2022 article

Hepatocellular carcinomas in captive prosimians

Robveille, C., & Cullen, J. M. (2022, July 25). VETERINARY PATHOLOGY.

By: C. Robveille* & J. Cullen

author keywords: hepatocellular carcinoma; lemur; metastasis; neoplasm; prosimians; cytokeratin 7; cytokeratin 19
Source: Web Of Science
Added: August 1, 2022

2022 journal article

The ZCCHC14/TENT4 complex is required for hepatitis A virus RNA synthesis

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119(28).

By: Y. Li, I. Misumi*, T. Shiota*, L. Sun*, E. Lenarcic*, H. Kim*, T. Shirasaki*, A. Hertel-Wulff* ...

author keywords: picornavirus; antiviral therapy; animal model; hepatitis A; RNA-binding protein
Source: Web Of Science
Added: September 29, 2022

2021 article

Choledochal cyst with secondary cholangitis, choledochitis, duodenal papillitis, and pancreatitis in a young domestic shorthair cat

Schreeg, M. E., Miller, S. A., & Cullen, J. M. (2021, May 24). JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION.

By: M. Schreeg, S. Miller* & J. Cullen

author keywords: bile ducts; cats; cholangitis; choledochal cyst; congenital; liver; pancreatitis
Source: Web Of Science
Added: June 10, 2021

2021 article

Ductal Plate Malformations in Captive Snakes

Patania, O. M., Troan, B. V., & Cullen, J. M. (2021, May 3). VETERINARY PATHOLOGY.

By: O. Patania n, B. Troan & J. Cullen

author keywords: bile ducts; ductal plate malformation; immunohistochemistry; liver; polycystic liver disease; snake; von Meyenburg complex
Source: Web Of Science
Added: June 14, 2021

2021 journal article

IRF3-mediated pathogenicity in a murine model of human hepatitis A

PLOS PATHOGENS, 17(9).

By: L. Sun*, Y. Li, I. Misumi*, O. Gonzalez-Lopez*, L. Hensley*, J. Cullen, D. McGivern*, M. Matsuda* ...

Source: Web Of Science
Added: February 28, 2022

2021 journal article

Iminosugar Glucosidase Inhibitors Reduce Hepatic Inflammation in Hepatitis A Virus-Infected Ifnar1(-/-) Mice

JOURNAL OF VIROLOGY, 95(11).

By: I. Misumi, Z. Li, L. Sun, A. Das, T. Shiota, J. Cullen, Q. Zhang, J. Whitmire, S. Lemon

author keywords: antiviral agents; ganglioside; hepatitis A virus; host response; iminosugar; liver immunology; miglustat; picornavirus
Source: Web Of Science
Added: June 10, 2021

2021 article

International Guidelines for Veterinary Tumor Pathology: A Call to Action

Meuten, D. J., Moore, F. M., Donovan, T. A., Bertram, C. A., Klopfleisch, R., Foster, R. A., … Whitley, D. (2021, July 20). VETERINARY PATHOLOGY.

author keywords: standardization; oncology; guidelines; protocols; validation
Source: Web Of Science
Added: August 2, 2021

2021 review

International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of the Dog

[Review of ]. TOXICOLOGIC PATHOLOGY, 49(1), 5–109.

By: J. Woicke*, M. Al-Haddawi*, J. Bienvenu*, J. Caverly Rae*, F. Chanut*, K. Colman*, J. Cullen, W. Davis* ...

author keywords: dog; pathology; toxicopathology; nomenclature; background findings; INHAND
Source: Web Of Science
Added: February 1, 2021

2021 journal article

T cells protect against hepatitis A virus infection and limit infection- induced liver injury

JOURNAL OF HEPATOLOGY, 75(6), 1323–1334.

author keywords: Hepatitis A Virus; mice; liver infection; liver pathogenesis; T cells; T cell vaccine; type-1 interferons
Source: Web Of Science
Added: December 13, 2021

2021 journal article

Using rheology to quantify the effects of localized collagenase treatments on uterine fibroid digestion

ACTA BIOMATERIALIA, 134, 443–452.

By: R. Corder, S. Gadi, R. Vachieri*, F. Jayes*, J. Cullen, S. Khan, D. Taylor*

author keywords: Uterine fibroids; Collagenase; Drug delivery; Rheology; Histology
Sources: Web Of Science, ORCID
Added: November 8, 2021

2020 review

An adverse outcome pathway for small intestinal tumors in mice involving chronic cytotoxicity and regenerative hyperplasia: a case study with hexavalent chromium, captan, and folpet

[Review of ]. CRITICAL REVIEWS IN TOXICOLOGY, 50(8), 685–706.

By: V. Bhat*, S. Cohen*, E. Gordon*, C. Wood*, J. Cullen, M. Harris*, D. Proctor*, C. Thompson*

author keywords: Adverse outcome pathway (AOP); small intestinal tumors; villous cytotoxicity; regenerative proliferation; crypt hyperplasia; cytotoxicity-mediated; non-DNA-reactive; mode of action (MOA); weight of evidence; hexavalent chromium; captan; folpet
Source: Web Of Science
Added: November 24, 2020

2020 journal article

Assessment of the Mode of Action Underlying the Effects of GenX in Mouse Liver and Implications for Assessing Human Health Risks

TOXICOLOGIC PATHOLOGY, 48(3), 494–508.

By: G. Chappell*, C. Thompson*, J. Wolf*, J. Cullen, J. Klaunig* & L. Haws*

author keywords: transcriptomics; perfluoroalkyl and polyfluoroalkyl substances (PFAS); GenX; mode of action; single-cell necrosis; peroxisome proliferator-activated receptor alpha (PPAR alpha)
Source: Web Of Science
Added: April 20, 2020

2020 journal article

Inter-Institutional Partnerships to Develop Veterinarian-Investigators through the NIH Comparative Biomedical Scientist Training Program Benefit One Health Goals

JOURNAL OF VETERINARY MEDICAL EDUCATION, 47(5), 619–631.

By: R. Simpson, S. Hoover, B. Davis, J. Hickerson, M. Miller, M. Kiupel, J. Cullen, J. Dwyer ...

author keywords: clinician-scientist; graduate education; veterinary medical education; investigative pathologist; veterinary specialty; veterinary pathology; DVM/PhD; comparative medicine; predictive translational modeling; NIH intramural research training award (IRTA); NCI cancer research training award (CRTA)
Source: Web Of Science
Added: December 21, 2020

2019 journal article

Comparative Pathology of Hepatitis A Virus and Hepatitis E Virus Infection

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 9(4).

By: J. Cullen & S. Lemon*

Source: Web Of Science
Added: April 15, 2019

2019 journal article

Computed Tomography of Lobular Dissecting Hepatitis in a Young Golden Retriever

JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION, 55(2).

By: E. Hostnik*, V. Parker n & J. Cullen

Source: Web Of Science
Added: March 4, 2019

2019 journal article

Development of an oral reference dose for the perfluorinated compound GenX

JOURNAL OF APPLIED TOXICOLOGY, 39(9), 1267–1282.

By: C. Thompson*, S. Fitch*, C. Ring*, W. Rish*, J. Cullen & L. Haws*

author keywords: benchmark dose (BMD) modeling; GenX; per- and polyfluoroalkyl substances (PFAS); reference dose (RfD); risk assessment
Source: Web Of Science
Added: September 9, 2019

2019 journal article

Reevaluation of Hepatocellular Neoplasms in CD-1 Mice from a 2-year Oral Carcinogenicity Study with Permethrin

TOXICOLOGIC PATHOLOGY, 47(1), 11–17.

By: E. Quist*, G. Boorman, J. Cullen, R. Maronpot*, A. Remick*, J. Swenberg*, L. Freshwater*, J. Hardisty

author keywords: permethrin; liver neoplasms; hepatocellular adenoma; hepatocellular carcinoma; Pathology Working Group
Source: Web Of Science
Added: February 11, 2019

2019 journal article

Virus discovery reveals frequent infection by diverse novel members of the Flaviviridae in wild lemurs

ARCHIVES OF VIROLOGY, 164(2), 509–522.

By: M. Canuti*, C. Williams*, S. Sagan*, B. Munnink*, S. Gadi, J. Verhoeven*, P. Kellam*, M. Cotten* ...

Source: Web Of Science
Added: March 4, 2019

2018 journal article

EVALUATION OF THE OPHTHALMIC DISEASE AND HISTOPATHOLOGIC EFFECTS DUE TO THE OCULAR TREMATODE PHILOPHTHALMUS ZALOPHI ON JUVENILE GALAPAGOS SEA LIONS (ZALOPHUS WOLLEBAEKI)

JOURNAL OF ZOO AND WILDLIFE MEDICINE, 49(3), 581–590.

By: B. Phillips n, D. Paez-Rosas*, J. Flowers, J. Cullen, J. Law, C. Colitz*, D. Deresienski, K. Lohmann*, G. Lewbart

author keywords: Conjunctival biopsy; eye trematode; Galapagos sea lion; Philophthalmus zalophi; Zalophus wollebaeki
Sources: Web Of Science, ORCID
Added: January 21, 2019

2018 journal article

Evaluation of potential serum biomarkers of hepatic fibrosis and necroinflammatory activity in dogs with liver disease

JOURNAL OF VETERINARY INTERNAL MEDICINE, 32(3), 1009–1018.

By: C. Raghu*, J. Ekena*, J. Cullen, C. Webb* & L. Trepanier*

author keywords: AST; CCL2; CRP; hepatitis; IL-6; MCP-1
Source: Web Of Science
Added: August 6, 2018

2018 journal article

MORTALITY IN COQUEREL'S SIFAKAS (PROPITHECUS COQUERELI) UNDER HUMAN CARE: A RETROSPECTIVE SURVEY FROM THE DUKE LEMUR CENTER 1990-2015

JOURNAL OF ZOO AND WILDLIFE MEDICINE, 49(2), 315–323.

By: K. Cassady, J. Cullen & C. Williams

author keywords: Coquerel's sifaka; lemur; mortality; Propithecus coquereli; prosimian
Source: Web Of Science
Added: August 6, 2018

2018 journal article

New parvovirus associated with serum hepatitis in horses after inoculation of common biological product

Emerging Infectious Diseases, 24(2), 303–310.

By: T. Divers, B. Tennant, A. Kumar, S. McDonough, J. Cullen, N. Bhuva, K. Jain, L. Chauhan ...

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

Qualitative metabolomics profiling of serum and bile from dogs with gallbladder mucocele formation

PLOS ONE, 13(1).

By: J. Gookin, K. Mathews, J. Cullen & G. Seiler

Sources: Web Of Science, ORCID
Added: August 6, 2018

2018 journal article

Viral persistence, liver disease, and host response in a hepatitis C-like virus rat model

Hepatology, 68(2), 435–448.

By: S. Trivedi*, S. Murthy*, H. Sharma*, A. Hartlage*, A. Kumar*, S. Gadi n, P. Simmonds*, L. Chauhan* ...

Source: Crossref
Added: February 21, 2020

2017 journal article

Interobserver Agreement Using Histological Scoring of the Canine

JOURNAL OF VETERINARY INTERNAL MEDICINE, 31(3), 778–783.

By: J. Lidbury*, A. Hoffmann*, R. Ivanek*, J. Cullen, B. Porter*, F. Oliveira*, T. Van Winkle*, G. Grinwis*, J. Sucholdolski*, J. Steiner*

author keywords: Chronic hepatitis; Dog; Hepatic fibrosis; histological scoring
Source: Web Of Science
Added: August 6, 2018

2017 journal article

MYCOBACTERIUM INTRACELLULARE INFECTION CAUSING A RETROPERITONEAL MASS IN A BINTURONG (ARCTICTIS BINTURONG)

JOURNAL OF ZOO AND WILDLIFE MEDICINE, 48(2), 544–548.

author keywords: Arctictis binturong; binturong; mycobacteriosis; Mycobacterium intracellulare; pyogranuloma
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

Mouse models of acute and chronic hepacivirus infection

SCIENCE, 357(6347), 204-+.

Source: Web Of Science
Added: August 6, 2018

2017 journal article

Other viruses: Hepeviridae, hepadnaviridae, deltaviruses, nodaviridae, and unclassified viruses

Fenner's Veterinary Virology, 5th Edition, 547–555.

By: J. Cullen & X. Meng

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

TIM1 (HAVCR1) Is Not Essential for Cellular Entry of Either Quasi-enveloped or Naked Hepatitis A Virions

MBIO, 8(5).

By: A. Das*, A. Hirai-Yuki*, O. Gonzalez-Lopez*, B. Rhein*, S. Moller-Tank*, R. Brouillette*, L. Hensley*, I. Misumi* ...

author keywords: hepatitis A virus; hepatovirus; phosphatidylserine; picornavirus; receptor; viral attachment
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Acute Alpha-Naphthylisothiocyanate-induced Liver Toxicity in Germfree and Conventional Male Rats

TOXICOLOGIC PATHOLOGY, 44(7), 987–997.

By: J. Cullen, B. Faiola*, D. Melich*, R. Peterson*, H. Jordan*, C. Kimbrough*, R. Miller*

author keywords: liver; bile duct; alpha-naphthylisothiocyanate; germfree; rat; toxicity
Source: Web Of Science
Added: August 6, 2018

2016 journal article

External beam radiation therapy of squamous cell carcinoma in the beak of an African grey parrot (Psittacus timneh)

Journal of Avian Medicine and Surgery, 30(3), 250–256.

By: S. Swisher n, K. Phillips, J. Tobias, J. Cullen, T. Gieger & V. Grunkemeyer

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2016 journal article

Histiocytic chorioretinitis in a dog

Veterinary Ophthalmology, 21(1), 88–95.

By: A. Sherman n, J. Cullen, H. Westermeyer, C. Grindem & B. Gilger

author keywords: canine; chorioretinitis; histiocytic; Melan-A; melanoma; retinal detachment
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2016 journal article

Histology Atlas of the Developing Mouse Hepatobiliary Hemolymphatic Vascular System with Emphasis on Embryonic Days 11.5-18.5 and Early Postnatal Development

TOXICOLOGIC PATHOLOGY, 44(5), 705–725.

author keywords: vascular development; lymphatic development; hepatobiliary development; portal sinus; embryo; mouse; atlas
Source: Web Of Science
Added: August 6, 2018

2016 journal article

MAVS-dependent host species range and pathogenicity of human hepatitis A virus

SCIENCE, 353(6307), 1541–1545.

By: A. Hirai-Yuki*, L. Hensley*, D. McGivern*, O. Gonzalez-Lopez*, A. Das*, H. Feng*, L. Sun*, J. Wilson* ...

Source: Web Of Science
Added: August 6, 2018

2016 journal article

Reevaluation and Classification of Duodenal Lesions in B6C3F1 Mice and F344 Rats from 4 Studies of Hexavalent Chromium in Drinking Water

TOXICOLOGIC PATHOLOGY, 44(2), 279–289.

By: J. Cullen, J. Ward* & C. Thompson*

author keywords: mouse pathology; rat pathology; gastrointestinal system; environmental toxicology; cell proliferation; carcinogenesis
Source: Web Of Science
Added: August 6, 2018

2016 article

The Strange, Expanding World of Animal Hepaciviruses

ANNUAL REVIEW OF VIROLOGY, VOL 3, Vol. 3, pp. 53–75.

By: A. Hartlage*, J. Cullen & A. Kapoor*

author keywords: hepatitis C virus; pegivirus; hepegivirus; virome; virus evolution; animal models
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Association of Gallbladder Mucocele Histologic Diagnosis with Selected Drug Use in Dogs: A Matched Case-Control Study

JOURNAL OF VETERINARY INTERNAL MEDICINE, 29(6), 1464–1472.

By: J. Gookin, M. Correa, A. Peters n, A. Malueg n, K. Mathews n, J. Cullen, G. Seiler

author keywords: Bile; Canine; Mucus; Xenobiotic
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

Canine urothelial carcinoma: genomically aberrant and comparatively relevant

Chromosome Research, 23(2), 311–331.

By: S. Shapiro n, S. Raghunath n, C. Williams, A. Motsinger-Reif, J. Cullen, T. Liu*, D. Albertson*, M. Ruvolo* ...

author keywords: Canine; Urothelial carcinoma; Transitional cell carcinoma; Cytogenetics; Chromosome aberration; Array comparative genomic hybridization; Comparative oncology
Sources: Crossref, Web Of Science
Added: August 6, 2018

2015 journal article

Clinical, histopathological and immunohistochemical characterization of a novel equine ocular disorder: heterochromic iridocyclitis with secondary keratitis in adult horses

VETERINARY OPHTHALMOLOGY, 18(6), 443–456.

author keywords: endotheliitis; iridocyclitis; keratic precipitates; keratitis; retrocorneal membrane; uveitis
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

Effects of azathioprine, 6-mercaptopurine, and 6-thioguanine on canine primary hepatocytes

AMERICAN JOURNAL OF VETERINARY RESEARCH, 76(7), 649–655.

By: K. LaDuke, S. Ehling, J. Cullen & W. Baeumer

Source: Web Of Science
Added: August 6, 2018

2015 journal article

Excess Secretion of Gel-Forming Mucins and Associated Innate Defense Proteins with Defective Mucin Un-Packaging Underpin Gallbladder Mucocele Formation in Dogs

PLOS ONE, 10(9).

By: M. Kesimer*, J. Cullen, R. Cao*, G. Radicioni*, K. Mathews n, G. Seiler, J. Gookin

Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

Biliary Proliferative Lesions in the Sprague-Dawley Rat: Adverse/Non-adverse

TOXICOLOGIC PATHOLOGY, 42(5), 844–854.

By: J. Hailey*, J. Nold*, R. Brown*, J. Cullen, J. Holder*, H. Jordan*, D. Ennulat*, R. Miller*

author keywords: rat; biliary; oval cell; adverse; proliferative; bile duct; hyperplasia
Source: Web Of Science
Added: August 6, 2018

2014 personal communication

Effects of excess dietary fructose on liver pathology study have significant methodologic limitations: Reply

By: K. Kavanagh, A. Wylie, K. Tucker, T. Hamp, R. Gharaibeh, A. Fodor, J. Cullen

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Evaluation of fluorescence in situ hybridization for the detection of bacteria in feline inflammatory liver disease

JOURNAL OF FELINE MEDICINE AND SURGERY, 16(2), 109–117.

By: D. Twedt*, J. Cullen, K. McCord*, S. Janeczko*, J. Dudak* & K. Simpson*

Source: Web Of Science
Added: August 6, 2018

2014 journal article

Hyperinsulinemic Hypoglycemia Syndrome in 2 Dogs with Bartonellosis

Journal of Veterinary Internal Medicine, 28(4), 1331–1335.

By: E. Breitschwerdt, C. Goldkamp*, W. Castleman*, J. Cullen, P. Mascarelli, L. Thalhem n, M. Schaer*

author keywords: Dog; Hyperinsulinemia; Hypoglycemia; Monocytosis; Seizures
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2014 journal article

Lack of association of ABCB4 insertion mutation with gallbladder mucoceles in dogs

JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, 26(3), 434–436.

By: J. Cullen, C. Willson n, J. Minch n, C. Kimbrough n & K. Mealey n

author keywords: ABCB4 gene; canine; gall bladder; mucocele
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Liver biomarker and in vitro assessment confirm the hepatic origin of aminotransferase elevations lacking histopathological correlate in beagle dogs treated with GABA(A) receptor antagonist NP260

TOXICOLOGY AND APPLIED PHARMACOLOGY, 277(2), 131–137.

By: A. Harrill*, J. Eaddy*, K. Rose*, J. Cullen, L. Ramanathan*, S. Wanaski*, S. Collins*, Y. Ho*, P. Watkins*, E. LeCluyse*

author keywords: Canine; Biomarker; Hepatotoxicity; Liver; Hepatic; miRNA; miR-122; GLDH; SDH
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Role of Pregnane X Receptor in Obesity and Glucose Homeostasis in Male Mice

JOURNAL OF BIOLOGICAL CHEMISTRY, 289(6), 3244–3261.

By: K. Spruiell*, R. Richardson*, J. Cullen, E. Awumey*, F. Gonzalez* & M. Gyamfi*

author keywords: Diabetes; Metabolic Syndrome; Nuclear Receptors; Obesity; Peroxisome Proliferator-activated Receptor (PPAR)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Role of human pregnane X receptor in high fat diet-induced obesity in pre-menopausal female mice

BIOCHEMICAL PHARMACOLOGY, 89(3), 399–412.

By: K. Spruiell*, D. Jones*, J. Cullen, E. Awumey*, F. Gonzalez* & M. Gyamfi*

author keywords: Obesity; High-fat diet; Pregnane X receptor; Nuclear receptors; Type 2 diabetes; Females
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Thymofibrolipoma in a Labrador Retriever

VETERINARY PATHOLOGY, 51(4), 816–819.

By: J. Tobias & J. Cullen

author keywords: dog; immunohistochemistry; thymoma; thymus gland
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Visualizing surface area and volume of lumens in three dimensions using images from histological sections

JOURNAL OF MICROSCOPY, 256(3), 190–196.

By: D. Livingston, T. Tuong, G. Kissling* & J. Cullen

author keywords: 3-D reconstruction; histology; liver; negative space; portal tract
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Cardiac structure and function in female carrier's of a canine model of Duchenne muscular dystrophy

RESEARCH IN VETERINARY SCIENCE, 94(3), 610–617.

By: A. Kane*, T. DeFrancesco, M. Boyle*, D. Malarkey*, J. Ritchey*, C. Atkins, J. Cullen, J. Kornegay*, B. Keene

author keywords: Cardiomyopathy; Carrier; GRMD; Duchenne muscular dystrophy
Sources: Web Of Science, ORCID
Added: August 6, 2018

2013 journal article

Chikungunya Virus Host Range E2 Transmembrane Deletion Mutants Induce Protective Immunity against Challenge in C57BL/6J Mice

JOURNAL OF VIROLOGY, 87(12), 6748–6757.

By: A. Piper, M. Ribeiro, K. Smith*, C. Briggs*, E. Huitt*, K. Nanda*, C. Spears*, M. Quiles* ...

Source: Web Of Science
Added: August 6, 2018

2013 journal article

Dietary fructose induces endotoxemia and hepatic injury in calorically controlled primates

AMERICAN JOURNAL OF CLINICAL NUTRITION, 98(2), 349–357.

By: K. Kavanagh*, A. Wylie, K. Tucker, T. Hamp, R. Gharaibeh, A. Fodor, J. Cullen

Source: Web Of Science
Added: August 6, 2018

2013 personal communication

From Bipeds to an Honorary Member of the American College of Veterinary Pathologists

Meuten, D. J., Law, J. M., Stromberg, P. C., & Cullen, J. M. (2013, May).

By: D. Meuten, J. Law, P. Stromberg* & J. Cullen

Source: Web Of Science
Added: August 6, 2018

2013 journal article

Granulomatous metritis caused by suspected Dirofilaria immitis in a dog: a case report

VETERINARNI MEDICINA, 58(8), 437–441.

By: J. Park, A. Kim, E. Lee, E. Lee, D. Kwak, I. Hong, J. Cullen, K. Jeong

author keywords: dog; filarid; granuloma; larva; nematode; uterus
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Necrolytic migratory erythema associated with a glucagon-producing primary hepatic neuroendocrine carcinoma in a cat

VETERINARY DERMATOLOGY, 24(4), 466–E110.

By: M. Asakawa, J. Cullen & K. Linder

Source: Web Of Science
Added: August 6, 2018

2013 personal communication

Primate fructose study misses mark due to preventable design flaws Reply

By: K. Kavanagh, A. Wylie, K. Tucker, T. Hamp, R. Gharaibeh, A. Fodor, J. Cullen

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Cutting Through to the Truth: Laser Capture Microscopy and Acute Toxic Biliary Injury

Journal of Comparative Pathology, 146(1), 45.

By: J. Cullen

Source: Crossref
Added: December 29, 2020

2012 journal article

Evaluation of diode endoscopic cyclophotocoagulation in bovine cadaver eyes

AMERICAN JOURNAL OF VETERINARY RESEARCH, 73(9), 1445–1452.

By: J. Harrington n, R. McMullen, J. Cullen & B. Gilger

Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 journal article

Limited yield of diagnoses of intrahepatic infectious causes of canine granulomatous hepatitis from archival liver tissue

Journal of Veterinary Diagnostic Investigation, 24(5), 888–894.

author keywords: Copper hepatopathy; dogs; fluorescent in situ hybridization; granulomatous hepatitis; polymerase chain reaction
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2012 journal article

Reye's or Reye's-like syndrome in western lowland gorilla (Gorilla gorilla gorilla)

JOURNAL OF MEDICAL PRIMATOLOGY, 41(5), 329–331.

By: L. Minter, J. Cullen & M. Loomis*

author keywords: encephalopathy; Gorilla gorilla gorilla; hepatopathy; Reye's syndrome; western lowland gorilla
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Serology-Enabled Discovery of Genetically Diverse Hepaciviruses in a New Host

JOURNAL OF VIROLOGY, 86(11), 6171–6178.

By: P. Burbelo*, E. Dubovi*, P. Simmonds*, J. Medina*, J. Henriquez*, N. Mishra*, J. Wagner*, R. Tokarz* ...

Source: Web Of Science
Added: August 6, 2018

2011 journal article

Development of an Animal Model for Radiofrequency Ablation of Primary, Virally Induced Hepatocellular Carcinoma in the Woodchuck

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 22(11), 1613–1618.

By: C. Burke*, J. Cullen, A. State*, S. Gadi, K. Wilber*, M. Rosenthal*, A. Bulysheva*, A. Pease n, M. Mauro*, H. Fuchs*

Source: Web Of Science
Added: August 6, 2018

2011 journal article

H-ras Consensus Sequence and Mutations in Primary Hepatocellular Carcinomas of Lemurs and Lorises

VETERINARY PATHOLOGY, 48(4), 868–874.

By: J. Cullen, C. Williams, L. Zadrozny, J. Otstot*, G. Solomon*, R. Sills, H. Hong*

author keywords: liver; molecular biology; oncology; primate; zoo; hepatocellular carcinoma
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Molecular cytogenetic characterization of canine histiocytic sarcoma: A spontaneous model for human histiocytic cancer identifies deletion of tumor suppressor genes and highlights influence of genetic background on tumor behavior

BMC Cancer, 11.

By: B. Hedan, R. Thomas, A. Motsinger-Reif, J. Abadie, C. Andre, J. Cullen, M. Breen

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Necropsy or Autopsy? It’s All About Communication!

Veterinary Pathology, 49(2), 271–272.

By: M. Law, P. Stromberg*, D. Meuten & J. Cullen

Sources: Web Of Science, Crossref
Added: August 6, 2018

2011 journal article

Recommended guidelines for submission, trimming, margin evaluation, and reporting of tumor biopsy specimens in veterinary surgical pathology

Veterinary Pathology, 48(1), 19–31.

By: D. Kamstock, E. Ehrhart, D. Getzy, N. Bacon, K. Rassnick, S. Moroff, S. Liu, R. Straw ...

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Recommended guidelines for the conduct and evaluation of prognostic studies in veterinary oncology

Veterinary Pathology, 48(1), 7–18.

By: J. Webster, M. Dennis, N. Dervisis, J. Heller, N. Bacon, P. Bergman, D. Bienzle, G. Cassali ...

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Acute ANIT Toxicity in Male IL-10 Knockout and Wild-type Mice

TOXICOLOGIC PATHOLOGY, 38(5), 745–755.

By: B. Faiola*, R. Peterson*, C. Kimbrough*, H. Jordan* & J. Cullen

author keywords: animal models; toxicologic pathology; hepatobiliary system; histopathology; knockout mouse; liver; mouse pathology
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Congenital Hepatic Fibrosis in 5 Dogs

VETERINARY PATHOLOGY, 47(1), 102–107.

By: D. Brown, T. Van Winkle*, T. Cecere, S. Rushton*, C. Brachelente* & J. Cullen

author keywords: bile ducts; biliary tract diseases; canine; embryonic development; liver
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Imaging diagnosis-neuronal ceroid lipofuscinosis with a chronic subdural hematoma

Veterinary Radiology & Ultrasound, 51(2), 155–158.

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Spontaneous Hepatocellular Carcinoma in Captive Prosimians

VETERINARY PATHOLOGY, 47(2), 306–311.

By: L. Zadrozny, C. Williams*, A. Remick* & J. Cullen

author keywords: Hepadnaviridae; hepatocellular carcinoma; iron; lemur; liver cell adenoma; neoplasms; prosimians
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Time Course Gene Expression Using Laser Capture Microscopy-Extracted Bile Ducts, but Not Hepatic Parenchyma, Reveals Acute Alpha-Naphthylisothiocyanate Toxicity

TOXICOLOGIC PATHOLOGY, 38(5), 715–729.

By: J. Cullen, J. Falls*, H. Brown*, L. Yoon*, N. Cariello*, B. Faiola*, C. Kimbrough*, H. Jordan*, R. Miller*

author keywords: bioinformatics; apoptosis/cell death; biotechnology; genomics; hepatobiliary system; histopathology; toxicity
Source: Web Of Science
Added: August 6, 2018

2009 journal article

ACQUIRED ARTERIOVENOUS FISTULA IN A GRIZZLY BEAR (URSUS ARCTOS HORRIBILIS)

JOURNAL OF ZOO AND WILDLIFE MEDICINE, 40(1), 193–195.

By: A. Tuttle, R. MacLean, K. Linder, J. Cullen, B. Wolfe & M. Loomis

author keywords: Acquired arteriovenous fistula; grizzly bear; Ursus arctos horribilis; trauma; wound
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Aflatoxin B1 and/or Hepatitis B Virus Induced Tumor Spectrum in a Genetically Engineered Hepatitis B Virus Expression and Trp53 Haploinsufficient Mouse Model System for Hepatocarcinogenesis

TOXICOLOGIC PATHOLOGY, 37(3), 333–342.

By: J. Cullen, D. Brown, G. Kissling*, J. Foley*, J. Rizzo n, P. Marion*, V. Parron*, J. French*

author keywords: aflatoxin B-1; hepatitis B virus; hepatocellular carcinoma; p53; transgenic; Trp53; tumorigenesis; FVB/N strain
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Microarray-based cytogenetic profiling reveals recurrent and subtype-associated genomic copy number aberrations in feline sarcomas

CHROMOSOME RESEARCH, 17(8), 987–1000.

By: R. Thomas, V. Valli*, P. Ellis*, J. Bell*, E. Karlsson*, J. Cullen, K. Lindblad-Toh*, C. Langford*, M. Breen

author keywords: microarray; comparative genomic hybridization (CGH); feline; sarcoma; chromosome
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Summary of the World Small Animal Veterinary Association Standardization Committee Guide to Classification of Liver Disease in Dogs and Cats

VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE, 39(3), 395-+.

By: J. Cullen

author keywords: Pathology; Histopathology; Liver; Classification; Dog; Cat
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Expression of CDK4 or CDK2 in mouse oral cavity is retained in adult pituitary with distinct effects on tumorigenesis

CANCER RESEARCH, 68(1), 162–171.

By: E. Macias, P. Marva, A. Senderowicz, J. Cullen & M. Rodriguez-Puebla

Source: Web Of Science
Added: August 6, 2018

2008 journal article

Harderian gland neoplasms in captive, wild-caught Beechey ground squirrels (Spermophilus beecheyi)

VETERINARY PATHOLOGY, 45(3), 388–392.

By: R. Ranck n, J. Cullen, K. Waggie* & P. Marion*

author keywords: carcinoma; ground squirrel hepatitis virus; ground squirrels; Harderian gland; Sciuridae
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Serologic survey of woodchuck hepatitis virus in North Carolina woodchucks (Marmota monax)

JOURNAL OF ZOO AND WILDLIFE MEDICINE, 39(2), 263–265.

By: J. Cullen, D. Lindsey-Pegram & P. Cote

author keywords: hepadnavirus; woodchuck; woodchuck hepatitis virus
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Selective deletion of antigen-specific CD8(+) T cells by MHC class I tetramers, coupled to the type I ribosome-inactivating protein saporin

BLOOD, 109(8), 3300–3307.

By: P. Hess, C. Barnes*, M. Woolard*, M. Johnson*, J. Cullen, E. Collins*, J. Frelinger*

Sources: Web Of Science, ORCID
Added: August 6, 2018

2007 journal article

The liver of woodchucks chronically infected with the woodchuck hepatitis virus contains foci of virus core antigen-negative hepatocytes with both altered and normal morphology

VIROLOGY, 359(2), 283–294.

By: C. Xu*, T. Yamamoto*, T. Zhou*, C. Aldrich*, K. Frank*, J. Cullen, A. Jilbert*, W. Mason*

author keywords: foci of altered hepatocytes; Woodchuck hepatitis virus; WHV; hepatocellular carcinoma
Source: Web Of Science
Added: August 6, 2018

2006 article

Fall panicum (Panicum dichotomiflorum) hepatotoxicosis in horses and sheep

JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 20, pp. 1414–1421.

By: A. Johnson, T. Divers, M. Freckleton, H. McKenzie, E. Mitchell, J. Cullen, S. McDonough

author keywords: apoptosis; hepatocyte necrosis; liver; steroidal saponins
Source: Web Of Science
Added: August 6, 2018

2006 journal article

P.050 Appearance of core antigen negative hepatocytes in woodchucks chronically infected with woodchuck hepatitis virus

Journal of Clinical Virology, 36, S76.

By: C. Xu, T. Yamamoto, T. Zhou, C. Aldrich, J. Cullen, A. Jilbert, W. Mason

Source: Crossref
Added: August 28, 2020

2006 review

The role of pathology in the identification of drug-induced hepatic toxicity

[Review of ]. EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 2(2), 241–247.

By: J. Cullen & R. Miller

author keywords: drug-induced toxicity; liver; pathology; safety assessment; toxicology
Source: Web Of Science
Added: August 6, 2018

2005 journal article

CDNA microarray analysis of HBV transgenic mouse liver identifies genes in lipid biosynthetic and growth control pathways affected by HBV

JOURNAL OF MEDICAL VIROLOGY, 77(1), 57–65.

By: M. Hajjou*, R. Norel*, R. Carver*, P. Marion*, J. Cullen, L. Rogler*, C. Rogler*

author keywords: gene expression; molecular virology; host-pathogen interaction
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Mechanistic Classification of Liver Injury

Toxicologic Pathology, 33(1), 6–8.

By: J. Cullen

author keywords: liver toxicity hepatocyte; cholestasis; apoptosis; autoimmunity; mitochondrial toxicity; cytochrome p450
Sources: NC State University Libraries, Crossref
Added: August 6, 2018

2005 journal article

Paraneoplastic pemphigus in a dog with splenic sarcoma

VETERINARY PATHOLOGY, 42(1), 88–91.

By: S. Elmore, J. Basseches, G. Anhalt, J. Cullen & T. Olivry

author keywords: autoantibodies; autoimmunity; blistering skin disease; canine; erythema multiforme; immunoblotting; immunofluorescence; immunoprecipitation; neoplasia; pemphigus; skin; spleen
Sources: Web Of Science, ORCID
Added: August 6, 2018

2004 journal article

Adenovirus-based gene therapy during clevudine treatment of woodchucks chronically infected with woodchuck hepatitis virus

VIROLOGY, 327(1), 26–40.

By: Y. Zhu*, J. Cullen, C. Aldrich*, J. Saputelli*, D. Miller*, C. Seeger*, W. Mason*, A. Jilbert*

author keywords: hepatitis B virus; clevudine; IFN-alpha
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Woodchuck interleukin-6 gene: structure,characterization, and biologic activity

GENE, 342(1), 157–164.

By: D. Li*, A. Kumanogoh*, T. Cao*, . Parnes* & J. Cullen

author keywords: interleukin-6; woodchuck hepatitis virus; human hepatitis B virus
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Detection of Bartonella henselae and Bartonella clarridgeiae DNA in hepatic specimens from two dogs with hepatic disease

Journal of the American Veterinary Medical Association, 222(1), 47–51.

By: T. Gillespie*, R. Washabau*, M. Goldschmidt*, J. Cullen, A. Rogala n & E. Breitschwerdt

Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2002 journal article

Helicobacter marmotae sp nov isolated from livers of woodchucks and intestines of cats

JOURNAL OF CLINICAL MICROBIOLOGY, 40(7), 2513–2519.

By: J. Fox*, Z. Shen*, S. Xu*, Y. Feng*, C. Dangler*, F. Dewhirst*, B. Paster*, J. Cullen

Source: Web Of Science
Added: August 6, 2018

2001 journal article

Antiviral efficacy and pharmacokinetics of oral adefovir dipivoxil in chronically woodchuck hepatitis virus-infected woodchucks

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 45(10), 2740–2745.

By: J. Cullen, D. Ll n, C. Brown, E. Eisenberg*, K. Cundy*, J. Wolfe*, J. Toole*, C. Gibbs*

Source: Web Of Science
Added: August 6, 2018

2001 article

Idiopathic noncirrhotic portal hypertension in dogs: 33 cases (1982-1998)

Bunch, S. E., Johnson, S. E., & Cullen, J. M. (2001, February 1). JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 218, pp. 392–399.

By: S. Bunch, S. Johnson & J. Cullen

Source: Web Of Science
Added: August 6, 2018

2001 journal article

Kinetics of hepadnavirus loss from the liver during inhibition of viral DNA synthesis

JOURNAL OF VIROLOGY, 75(1), 311–322.

By: Y. Zhu*, T. Yamamoto*, J. Cullen, J. Saputelli*, C. Aldrich*, D. Miller*, S. Litwin*, P. Furman*, A. Jilbert*, W. Mason*

Source: Web Of Science
Added: August 6, 2018

2001 journal article

T-helper cell response to woodchuck hepatitis virus antigens after therapeutic vaccination of chronically-infected animals treated with lamivudine

JOURNAL OF HEPATOLOGY, 35(1), 105–111.

author keywords: woodchuck hepatitis virus; lamivudine; Th1/Th2; therapeutic vaccination
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Sustained survival of human hepatocytes in mice: A model for in vivo infection with human hepatitis B and hepatitis delta viruses

Nature Medicine, 6(3), 327–331.

By: K. Ohashi*, P. Marion*, H. Nakai*, L. Meuse*, J. Cullen, B. Bordier*, R. Schwall*, H. Greenberg*, J. Glenn*, M. Kay*

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Woodchuck lymphotoxin-alpha, -beta and tumor necrosis factor genes: structure, characterization and biological activity

GENE, 242(1-2), 295–305.

By: D. Li n, E. Havell, C. Brown & J. Cullen

author keywords: cDNA; cytotoxicity; gene; LT; TNF; transcription factor binding site
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Hydranencephaly and cerebellar hypoplasia in two kittens attributed to intrauterine parvovirus infection

JOURNAL OF COMPARATIVE PATHOLOGY, 121(1), 39–53.

By: N. Sharp n, B. Davis*, J. Guy, J. Cullen, S. Steingold n & J. Kornegay

Sources: Web Of Science, ORCID
Added: August 6, 2018

1998 journal article

Lamivudine therapy of WHV-infected woodchucks

VIROLOGY, 245(1), 18–32.

By: W. Mason*, J. Cullen, G. Moraleda*, J. Saputelli*, C. Aldrich*, D. Miller*, B. Tennant*, L. Frick* ...

Source: Web Of Science
Added: August 6, 2018

1997 journal article

In vivo antiviral activity and pharmacokinetics of (-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine in woodchuck hepatitis virus-infected woodchucks

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 41(10), 2076–2082.

By: J. Cullen, S. Smith n, M. Davis n, S. Dunn n, C. Botteron n, A. Cecchi n, D. Linsey n, D. Linzey n ...

Source: Web Of Science
Added: August 6, 2018

1997 journal article

Therapeutic vaccination of woodchucks against chronic woodchuck hepatitis virus infection

JOURNAL OF HEPATOLOGY, 27(4), 726–737.

author keywords: antibodies; hepatitis; immune therapy; peptides; T-cell help; vaccination; woodchuck; woodchuck hepatitis virus (WHV); woodchuck hepatitis virus surface antigen (WHsAg)
Source: Web Of Science
Added: August 6, 2018

1993 journal article

HISTOLOGIC CHARACTERIZATION OF HEPATIC CARCINOGENESIS IN TRANSGENIC MICE EXPRESSING SV40 T-ANTIGENS

VETERINARY PATHOLOGY, 30(2), 111–118.

By: J. Cullen, E. Sandgren*, R. Brinster* & R. Maronpot*

author keywords: LIVER; NEOPLASIA; ONCOGENE; SIMIAN VIRUS-40; T-ANTIGENS; TRANSGENIC MICE
Source: Web Of Science
Added: August 6, 2018

1990 journal article

Hepatic neoplasms in aflatoxin B1-treated, congenital duck hepatitis B virus-infected, and virus-free Pekin ducks

Cancer Research, 50(13), 4072.

By: J. Cullen, P. Marion, G. Sherman, X. Hong & J. Newbold

Source: NC State University Libraries
Added: August 6, 2018

1987 journal article

Pathologic manifestations of experimental Babesia microti infection in hamsters

Laboratory Animal Science, 37, 640–643.

By: J. Cullen & J. Levine

Source: NC State University Libraries
Added: August 6, 2018

journal article

The MTAP-CDKN2A locus confers susceptibility to a naturally occurring canine cancer

Shearin, A. L., Hedan, B., Cadieu, E., Erich, S. A., Schmidt, E. V., Faden, D. L., … Andre, C. Cancer Epidemiology Biomarkers, 21(7), 1019–1027.

By: A. Shearin, B. Hedan, E. Cadieu, S. Erich, E. Schmidt, D. Faden, J. Cullen, J. Abadie ...

Source: NC State University Libraries
Added: August 6, 2018