John Cullen

Beatty, J. A., Tu, T., Pesavento, P. A., Cavasin, J. P., Chen, M.-C., Lidbury, J. A., … Cullen, J. M. (2024). Reply to Piewbang et al. Domestic Cat Hepadnavirus Antigens in Lymphoma Tissues. Comment on "Beatty et al. Domestic Cat Hepadnavirus and Lymphoma. <i>Viruses</i> 2023, <i>15</i>, 2294". VIRUSES-BASEL, 16(1). https://doi.org/10.3390/v16010149

Thompson, C. M., Heintz, M. M., Wolf, J. C., Cheru, R., Haws, L. C., & Cullen, J. M. (2023, March 29). Assessment of Mouse Liver Histopathology Following Exposure to HFPO-DA With Emphasis on Understanding Mechanisms of Hepatocellular Death. TOXICOLOGIC PATHOLOGY. https://doi.org/10.1177/01926233231159078

Heintz, M. M., Haws, L. C., Klaunig, J. E., Cullen, J. M., & Thompson, C. M. (2023, January 11). Assessment of the mode of action underlying development of liver lesions in mice following oral exposure to HFPO-DA and relevance to humans. TOXICOLOGICAL SCIENCES. https://doi.org/10.1093/toxsci/kfad004

Subramaniam, S., Fares-Gusmao, R., Sato, S., Cullen, J. M., Takeda, K., Farci, P., & Mcgivern, D. R. (2023). Distinct disease features of acute and persistent genotype 3 hepatitis E virus infection in immunocompetent and immunosuppressed Mongolian gerbils. PLOS PATHOGENS, 19(9). https://doi.org/10.1371/journal.ppat.1011664

Beatty, J. A., Tu, T., Pesavento, P. A., Cavasin, J. P., Chen, M.-C., Lidbury, J. A., … Cullen, J. M. (2023, December). Domestic Cat Hepadnavirus and Lymphoma. VIRUSES-BASEL, Vol. 15. https://doi.org/10.3390/v15122294

Wheatley, M. A., Shamoun, J., Maggi, R., Breitschwerdt, E. B., Sommer, S. L., Cullen, J. M., & Stowe, D. M. (2023). Eosinophilic pericardial effusion and pericarditis in a cat. JOURNAL OF FELINE MEDICINE AND SURGERY OPEN REPORTS, 9(2). https://doi.org/10.1177/20551169231213498

Gookin, J. L., Hartley, A. N., Aicher, K. M., Mathews, K. G., Cullen, R., Cullen, J. M., … Stauffer, S. H. (2023). Gallbladder microbiota in healthy dogs and dogs with mucocele formation. PLOS ONE, 18(2). https://doi.org/10.1371/journal.pone.0281432

Schreeg, M. E., Cullen, J. M., Robertson, J., & Gookin, J. L. (2023, August 10). Histologic characterization of the major duodenal papilla and association with concurrent biliary, pancreatic, and intestinal pathology in cats. VETERINARY PATHOLOGY, Vol. 8. https://doi.org/10.1177/03009858231189450

Hughes, K., Radakovic, M., Gorman, F., Malinowska, B., & Cullen, J. M. (2023). Immunohistochemical characterization of clear cell variant of hepatocellular carcinoma in a sheep. JOURNAL OF COMPARATIVE PATHOLOGY, 204, 47–50. https://doi.org/10.1016/j.jcpa.2023.06.002

Wong, H. E., Cullen, J. M., Vila-Gonzalez, M., Pittaway, R., Desmet, V. J., & Gillian, T. D. (2023, January 4). Patent hepatic ciliated foregut remnant resulting in an umbilicobiliary sinus tract, with gallbladder agenesis, in an 8-wk-old male French Bulldog. JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION. https://doi.org/10.1177/10406387221147317

Dravid, P., Murthy, S., Attia, Z., Cassady, C., Chandra, R., Trivedi, S., … Kapoor, A. (2023). Phenotype and fate of liver-resident CD8 T cells during acute and chronic hepacivirus infection. PLOS PATHOGENS, 19(10). https://doi.org/10.1371/journal.ppat.1011697

Kang, D., Womble, M., Cullen, J. M., Harrison, T. M., Premanandan, C., & Schreeg, M. E. (2023, November 28). Severe bronchiectasis resulting from chronic bacterial bronchitis and bronchopneumonia in a jungle cat. JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, Vol. 11. https://doi.org/10.1177/10406387231216181

Sun, L., Feng, H., Misumi, I., Shirasaki, T., Hensley, L., Gonzalez-Lopez, O., … Lemon, S. M. (2023). Viral protease cleavage of MAVS in genetically modified mice with hepatitis A virus infection. JOURNAL OF HEPATOLOGY, 78(2), 271–280. https://doi.org/10.1016/j.jhep.2022.09.013

Robveille, C., & Cullen, J. M. (2022, July 25). Hepatocellular carcinomas in captive prosimians. VETERINARY PATHOLOGY. https://doi.org/10.1177/03009858221114471

Li, Y., Misumi, I., Shiota, T., Sun, L., Lenarcic, E. M., Kim, H., … Lemon, S. M. (2022). The ZCCHC14/TENT4 complex is required for hepatitis A virus RNA synthesis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119(28). https://doi.org/10.1073/pnas.2204511119

Schreeg, M. E., Miller, S. A., & Cullen, J. M. (2021, May 24). Choledochal cyst with secondary cholangitis, choledochitis, duodenal papillitis, and pancreatitis in a young domestic shorthair cat. JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION. https://doi.org/10.1177/10406387211017107

Patania, O. M., Troan, B. V., & Cullen, J. M. (2021, May 3). Ductal Plate Malformations in Captive Snakes. VETERINARY PATHOLOGY. https://doi.org/10.1177/03009858211011941

Sun, L., Li, Y., Misumi, I., Gonzalez-Lopez, O., Hensley, L., Cullen, J. M., … Lemon, S. M. (2021). IRF3-mediated pathogenicity in a murine model of human hepatitis A. PLOS PATHOGENS, 17(9). https://doi.org/10.1371/journal.ppat.1009960

Misumi, I., Li, Z., Sun, L., Das, A., Shiota, T., Cullen, J., … Lemon, S. M. (2021). Iminosugar Glucosidase Inhibitors Reduce Hepatic Inflammation in Hepatitis A Virus-Infected Ifnar1(-/-) Mice. JOURNAL OF VIROLOGY, 95(11). https://doi.org/10.1128/JVI.00058-21.10

Meuten, D. J., Moore, F. M., Donovan, T. A., Bertram, C. A., Klopfleisch, R., Foster, R. A., … Whitley, D. (2021, July 20). International Guidelines for Veterinary Tumor Pathology: A Call to Action. VETERINARY PATHOLOGY. https://doi.org/10.1177/03009858211013712

Woicke, J., Al-Haddawi, M. M., Bienvenu, J.-G., Caverly Rae, J. M., Chanut, F. J., Colman, K., … Meseck, E. K. (2021). [Review of International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of the Dog]. TOXICOLOGIC PATHOLOGY, 49(1), 5–109. https://doi.org/10.1177/0192623320968181

Misumi, I., Mitchell, J. E., Lund, M. M., Cullen, J. M., Lemon, S. M., & Whitmire, J. K. (2021). T cells protect against hepatitis A virus infection and limit infection- induced liver injury. JOURNAL OF HEPATOLOGY, 75(6), 1323–1334. https://doi.org/10.1016/j.jhep.2021.07.019

Corder, R. D., Gadi, S. V., Vachieri, R. B., Jayes, F. L., Cullen, J. M., Khan, S. A., & Taylor, D. K. (2021). Using rheology to quantify the effects of localized collagenase treatments on uterine fibroid digestion. ACTA BIOMATERIALIA, 134, 443–452. https://doi.org/10.1016/j.actbio.2021.08.003

Bhat, V. S., Cohen, S. M., Gordon, E. B., Wood, C. E., Cullen, J. M., Harris, M. A., … Thompson, C. M. (2020). [Review of An adverse outcome pathway for small intestinal tumors in mice involving chronic cytotoxicity and regenerative hyperplasia: a case study with hexavalent chromium, captan, and folpet]. CRITICAL REVIEWS IN TOXICOLOGY, 50(8), 685–706. https://doi.org/10.1080/10408444.2020.1823934

Chappell, G. A., Thompson, C. M., Wolf, J. C., Cullen, J. M., Klaunig, J. E., & Haws, L. C. (2020). Assessment of the Mode of Action Underlying the Effects of GenX in Mouse Liver and Implications for Assessing Human Health Risks. TOXICOLOGIC PATHOLOGY, 48(3), 494–508. https://doi.org/10.1177/0192623320905803

Simpson, R. M., Hoover, S. B., Davis, B. J., Hickerson, J., Miller, M. A., Kiupel, M., … Samal, S. K. (2020). Inter-Institutional Partnerships to Develop Veterinarian-Investigators through the NIH Comparative Biomedical Scientist Training Program Benefit One Health Goals. JOURNAL OF VETERINARY MEDICAL EDUCATION, 47(5), 619–631. https://doi.org/10.3138/jvme.2019-0091

Cullen, J. M., & Lemon, S. M. (2019). Comparative Pathology of Hepatitis A Virus and Hepatitis E Virus Infection. COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 9(4). https://doi.org/10.1101/cshperspect.a033456

Hostnik, E. T., Parker, V. J., & Cullen, J. M. (2019). Computed Tomography of Lobular Dissecting Hepatitis in a Young Golden Retriever. JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION, 55(2). https://doi.org/10.5326/JAAHA-MS-6867

Thompson, C. M., Fitch, S. E., Ring, C., Rish, W., Cullen, J. M., & Haws, L. C. (2019). Development of an oral reference dose for the perfluorinated compound GenX. JOURNAL OF APPLIED TOXICOLOGY, 39(9), 1267–1282. https://doi.org/10.1002/jat.3812

Quist, E. M., Boorman, G. A., Cullen, J. M., Maronpot, R. R., Remick, A. K., Swenberg, J. A., … Hardisty, J. F. (2019). Reevaluation of Hepatocellular Neoplasms in CD-1 Mice from a 2-year Oral Carcinogenicity Study with Permethrin. TOXICOLOGIC PATHOLOGY, 47(1), 11–17. https://doi.org/10.1177/0192623318809304

Canuti, M., Williams, C. V., Sagan, S. M., Munnink, B. B. O., Gadi, S., Verhoeven, J. T. P., … Hoek, L. (2019). Virus discovery reveals frequent infection by diverse novel members of the Flaviviridae in wild lemurs. ARCHIVES OF VIROLOGY, 164(2), 509–522. https://doi.org/10.1007/s00705-018-4099-9

Phillips, B. E., Paez-Rosas, D., Flowers, J. R., Cullen, J. M., Law, J. M., Colitz, C., … Lewbart, G. A. (2018). EVALUATION OF THE OPHTHALMIC DISEASE AND HISTOPATHOLOGIC EFFECTS DUE TO THE OCULAR TREMATODE PHILOPHTHALMUS ZALOPHI ON JUVENILE GALAPAGOS SEA LIONS (ZALOPHUS WOLLEBAEKI). JOURNAL OF ZOO AND WILDLIFE MEDICINE, 49(3), 581–590. https://doi.org/10.1638/2017-0096.1

Raghu, C., Ekena, J., Cullen, J. M., Webb, C. B., & Trepanier, L. A. (2018). Evaluation of potential serum biomarkers of hepatic fibrosis and necroinflammatory activity in dogs with liver disease. JOURNAL OF VETERINARY INTERNAL MEDICINE, 32(3), 1009–1018. https://doi.org/10.1111/jvim.15064

Cassady, K., Cullen, J. M., & Williams, C. V. (2018). MORTALITY IN COQUEREL'S SIFAKAS (PROPITHECUS COQUERELI) UNDER HUMAN CARE: A RETROSPECTIVE SURVEY FROM THE DUKE LEMUR CENTER 1990-2015. JOURNAL OF ZOO AND WILDLIFE MEDICINE, 49(2), 315–323. https://doi.org/10.1638/2017-0242.1

Divers, T. J., Tennant, B. C., Kumar, A., McDonough, S., Cullen, J., Bhuva, N., … Dubovi, E. (2018). New parvovirus associated with serum hepatitis in horses after inoculation of common biological product. Emerging Infectious Diseases, 24(2), 303–310.

Gookin, J. L., Mathews, K. G., Cullen, J., & Seiler, G. (2018). Qualitative metabolomics profiling of serum and bile from dogs with gallbladder mucocele formation. PLOS ONE, 13(1). https://doi.org/10.1371/journal.pone.0191076

Trivedi, S., Murthy, S., Sharma, H., Hartlage, A. S., Kumar, A., Gadi, S. V., … Kapoor, A. (2018). Viral persistence, liver disease, and host response in a hepatitis C-like virus rat model. Hepatology, 68(2), 435–448. https://doi.org/10.1002/HEP.29494

Lidbury, J. A., Hoffmann, A. R., Ivanek, R., Cullen, J. M., Porter, B. F., Oliveira, F., … Steiner, J. M. (2017). Interobserver Agreement Using Histological Scoring of the Canine. JOURNAL OF VETERINARY INTERNAL MEDICINE, 31(3), 778–783. https://doi.org/10.1111/jvim.14684

Adamovicz, L., Kennedy-Stoskopf, S., Talley, A., Cullen, J. M., Cohen, E. B., Bizikova, P., & Grunkemeyer, V. (2017). MYCOBACTERIUM INTRACELLULARE INFECTION CAUSING A RETROPERITONEAL MASS IN A BINTURONG (ARCTICTIS BINTURONG). JOURNAL OF ZOO AND WILDLIFE MEDICINE, 48(2), 544–548. https://doi.org/10.1638/2016-0117r.1

Billerbeck, E., Wolfisberg, R., Fahnoe, U., Xiao, J. W., Quirk, C., Luna, J. M., … Rice, C. M. (2017). Mouse models of acute and chronic hepacivirus infection. SCIENCE, 357(6347), 204-+. https://doi.org/10.1126/science.aal1962

Cullen, J. M., & Meng, X. J. (2017). Other viruses: Hepeviridae, hepadnaviridae, deltaviruses, nodaviridae, and unclassified viruses. Fenner's Veterinary Virology, 5th Edition, 547–555.

Das, A., Hirai-Yuki, A., Gonzalez-Lopez, O., Rhein, B., Moller-Tank, S., Brouillette, R., … Lemon, S. M. (2017). TIM1 (HAVCR1) Is Not Essential for Cellular Entry of Either Quasi-enveloped or Naked Hepatitis A Virions. MBIO, 8(5). https://doi.org/10.1128/mbio.00969-17

Cullen, J. M., Faiola, B., Melich, D. H., Peterson, R. A., Jordan, H. L., Kimbrough, C. L., & Miller, R. T. (2016). Acute Alpha-Naphthylisothiocyanate-induced Liver Toxicity in Germfree and Conventional Male Rats. TOXICOLOGIC PATHOLOGY, 44(7), 987–997. https://doi.org/10.1177/0192623316662360

Swisher, S. D., Phillips, K. L., Tobias, J. R., Cullen, J. M., Gieger, T., & Grunkemeyer, V. L. (2016). External beam radiation therapy of squamous cell carcinoma in the beak of an African grey parrot (Psittacus timneh). Journal of Avian Medicine and Surgery, 30(3), 250–256. https://doi.org/10.1647/2015-106

Sherman, A. B., Cullen, J. M., Westermeyer, H. D., Grindem, C., & Gilger, B. C. (2016). Histiocytic chorioretinitis in a dog. Veterinary Ophthalmology, 21(1), 88–95. https://doi.org/10.1111/vop.12421

Swartley, O. M., Foley, J. F., Livingston, D. P., III, Cullen, J. M., & Elmore, S. A. (2016). Histology Atlas of the Developing Mouse Hepatobiliary Hemolymphatic Vascular System with Emphasis on Embryonic Days 11.5-18.5 and Early Postnatal Development. TOXICOLOGIC PATHOLOGY, 44(5), 705–725. https://doi.org/10.1177/0192623316630836

Hirai-Yuki, A., Hensley, L., McGivern, D. R., Gonzalez-Lopez, O., Das, A., Feng, H., … Lemon, S. M. (2016). MAVS-dependent host species range and pathogenicity of human hepatitis A virus. SCIENCE, 353(6307), 1541–1545. https://doi.org/10.1126/science.aaf8325

Cullen, J. M., Ward, J. M., & Thompson, C. M. (2016). Reevaluation and Classification of Duodenal Lesions in B6C3F1 Mice and F344 Rats from 4 Studies of Hexavalent Chromium in Drinking Water. TOXICOLOGIC PATHOLOGY, 44(2), 279–289. https://doi.org/10.1177/0192623315611501

Hartlage, A. S., Cullen, J. M., & Kapoor, A. (2016). The Strange, Expanding World of Animal Hepaciviruses. ANNUAL REVIEW OF VIROLOGY, VOL 3, Vol. 3, pp. 53–75. https://doi.org/10.1146/annurev-virology-100114-055104

Gookin, J. L., Correa, M. T., Peters, A., Malueg, A., Mathews, K. G., Cullen, J., & Seiler, G. (2015). Association of Gallbladder Mucocele Histologic Diagnosis with Selected Drug Use in Dogs: A Matched Case-Control Study. JOURNAL OF VETERINARY INTERNAL MEDICINE, 29(6), 1464–1472. https://doi.org/10.1111/jvim.13649

Shapiro, S. G., Raghunath, S., Williams, C., Motsinger-Reif, A. A., Cullen, J. M., Liu, T., … Breen, M. (2015). Canine urothelial carcinoma: genomically aberrant and comparatively relevant. Chromosome Research, 23(2), 311–331. https://doi.org/10.1007/S10577-015-9471-Y

Pinto, N. I., McMullen, R. J., Jr., Linder, K. E., Cullen, J. M., & Gilger, B. C. (2015). Clinical, histopathological and immunohistochemical characterization of a novel equine ocular disorder: heterochromic iridocyclitis with secondary keratitis in adult horses. VETERINARY OPHTHALMOLOGY, 18(6), 443–456. https://doi.org/10.1111/vop.12234

LaDuke, K. E., Ehling, S., Cullen, J. M., & Baeumer, W. (2015). Effects of azathioprine, 6-mercaptopurine, and 6-thioguanine on canine primary hepatocytes. AMERICAN JOURNAL OF VETERINARY RESEARCH, 76(7), 649–655. https://doi.org/10.2460/ajvr.76.7.649

Kesimer, M., Cullen, J., Cao, R., Radicioni, G., Mathews, K. G., Seiler, G., & Gookin, J. L. (2015). Excess Secretion of Gel-Forming Mucins and Associated Innate Defense Proteins with Defective Mucin Un-Packaging Underpin Gallbladder Mucocele Formation in Dogs. PLOS ONE, 10(9). https://doi.org/10.1371/journal.pone.0138988

Hailey, J. R., Nold, J. B., Brown, R. H., Cullen, J. M., Holder, J. C., Jordan, H. L., … Miller, R. T. (2014). Biliary Proliferative Lesions in the Sprague-Dawley Rat: Adverse/Non-adverse. TOXICOLOGIC PATHOLOGY, 42(5), 844–854. https://doi.org/10.1177/0192623313499976

Kavanagh, K., Wylie, A. T., Tucker, K. L., Hamp, T. J., Gharaibeh, R. Z., Fodor, A. A., & Cullen, J. M. (2014). Effects of excess dietary fructose on liver pathology study have significant methodologic limitations: Reply.

Twedt, D. C., Cullen, J., McCord, K., Janeczko, S., Dudak, J., & Simpson, K. (2014). Evaluation of fluorescence in situ hybridization for the detection of bacteria in feline inflammatory liver disease. JOURNAL OF FELINE MEDICINE AND SURGERY, 16(2), 109–117. https://doi.org/10.1177/1098612x13498249

Breitschwerdt, E. B., Goldkamp, C., Castleman, W. L., Cullen, J. M., Mascarelli, P. E., Thalhem, L., & Schaer, M. (2014). Hyperinsulinemic Hypoglycemia Syndrome in 2 Dogs with Bartonellosis. Journal of Veterinary Internal Medicine, 28(4), 1331–1335. https://doi.org/10.1111/jvim.12381

Cullen, J. M., Willson, C. J., Minch, J. D., Kimbrough, C. L., & Mealey, K. L. (2014). Lack of association of ABCB4 insertion mutation with gallbladder mucoceles in dogs. JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, 26(3), 434–436. https://doi.org/10.1177/1040638714532099

Harrill, A. H., Eaddy, J. S., Rose, K., Cullen, J. M., Ramanathan, L., Wanaski, S., … LeCluyse, E. L. (2014). Liver biomarker and in vitro assessment confirm the hepatic origin of aminotransferase elevations lacking histopathological correlate in beagle dogs treated with GABA(A) receptor antagonist NP260. TOXICOLOGY AND APPLIED PHARMACOLOGY, 277(2), 131–137. https://doi.org/10.1016/j.taap.2014.03.015

Spruiell, K., Richardson, R. M., Cullen, J. M., Awumey, E. M., Gonzalez, F. J., & Gyamfi, M. A. (2014). Role of Pregnane X Receptor in Obesity and Glucose Homeostasis in Male Mice. JOURNAL OF BIOLOGICAL CHEMISTRY, 289(6), 3244–3261. https://doi.org/10.1074/jbc.m113.494575

Spruiell, K., Jones, D. Z., Cullen, J. M., Awumey, E. M., Gonzalez, F. J., & Gyamfi, M. A. (2014). Role of human pregnane X receptor in high fat diet-induced obesity in pre-menopausal female mice. BIOCHEMICAL PHARMACOLOGY, 89(3), 399–412. https://doi.org/10.1016/j.bcp.2014.03.019

Tobias, J. R., & Cullen, J. M. (2014). Thymofibrolipoma in a Labrador Retriever. VETERINARY PATHOLOGY, 51(4), 816–819. https://doi.org/10.1177/0300985813502816

Livingston, D. P., III, Tuong, T. D., Kissling, G. E., & Cullen, J. M. (2014). Visualizing surface area and volume of lumens in three dimensions using images from histological sections. JOURNAL OF MICROSCOPY, 256(3), 190–196. https://doi.org/10.1111/jmi.12171

Kane, A. M., DeFrancesco, T. C., Boyle, M. C., Malarkey, D. E., Ritchey, J. W., Atkins, C. E., … Keene, B. W. (2013). Cardiac structure and function in female carrier's of a canine model of Duchenne muscular dystrophy. RESEARCH IN VETERINARY SCIENCE, 94(3), 610–617. https://doi.org/10.1016/j.rvsc.2012.09.027

Piper, A., Ribeiro, M., Smith, K. M., Briggs, C. M., Huitt, E., Nanda, K., … Hernandez, R. (2013). Chikungunya Virus Host Range E2 Transmembrane Deletion Mutants Induce Protective Immunity against Challenge in C57BL/6J Mice. JOURNAL OF VIROLOGY, 87(12), 6748–6757. https://doi.org/10.1128/jvi.03357-12

Kavanagh, K., Wylie, A. T., Tucker, K. L., Hamp, T. J., Gharaibeh, R. Z., Fodor, A. A., & Cullen, J. M. (2013). Dietary fructose induces endotoxemia and hepatic injury in calorically controlled primates. AMERICAN JOURNAL OF CLINICAL NUTRITION, 98(2), 349–357. https://doi.org/10.3945/ajcn.112.057331

Meuten, D. J., Law, J. M., Stromberg, P. C., & Cullen, J. M. (2013, May). From Bipeds to an Honorary Member of the American College of Veterinary Pathologists. https://doi.org/10.1177/0300985813480219

Park, J. K., Kim, A. Y., Lee, E. M., Lee, E. J., Kwak, D. M., Hong, I. H., … Jeong, K. S. (2013). Granulomatous metritis caused by suspected Dirofilaria immitis in a dog: a case report. VETERINARNI MEDICINA, 58(8), 437–441. https://doi.org/10.17221/6984-vetmed

Asakawa, M. G., Cullen, J. M., & Linder, K. E. (2013). Necrolytic migratory erythema associated with a glucagon-producing primary hepatic neuroendocrine carcinoma in a cat. VETERINARY DERMATOLOGY, 24(4), 466–E110. https://doi.org/10.1111/vde.12041

Kavanagh, K., Wylie, A. T., Tucker, K. L., Hamp, T. J., Gharaibeh, R. Z., Fodor, A. A., & Cullen, J. M. (2013). Primate fructose study misses mark due to preventable design flaws Reply.

Cullen, J. M. (2012). Cutting Through to the Truth: Laser Capture Microscopy and Acute Toxic Biliary Injury. Journal of Comparative Pathology, 146(1), 45. https://doi.org/10.1016/j.jcpa.2011.11.002

Harrington, J. T., McMullen, R. J., Jr., Cullen, J. M., & Gilger, B. C. (2012). Evaluation of diode endoscopic cyclophotocoagulation in bovine cadaver eyes. AMERICAN JOURNAL OF VETERINARY RESEARCH, 73(9), 1445–1452. https://doi.org/10.2460/ajvr.73.9.1445

Hutchins, R. G., Breitschwerdt, E. B., Cullen, J. M., Bissett, S. A., & Gookin, J. L. (2012). Limited yield of diagnoses of intrahepatic infectious causes of canine granulomatous hepatitis from archival liver tissue. Journal of Veterinary Diagnostic Investigation, 24(5), 888–894. https://doi.org/10.1177/1040638712453583

Minter, L. J., Cullen, J. M., & Loomis, M. R. (2012). Reye's or Reye's-like syndrome in western lowland gorilla (Gorilla gorilla gorilla). JOURNAL OF MEDICAL PRIMATOLOGY, 41(5), 329–331. https://doi.org/10.1111/j.1600-0684.2012.00554.x

Burbelo, P. D., Dubovi, E. J., Simmonds, P., Medina, J. L., Henriquez, J. A., Mishra, N., … Kapoor, A. (2012). Serology-Enabled Discovery of Genetically Diverse Hepaciviruses in a New Host. JOURNAL OF VIROLOGY, 86(11), 6171–6178. https://doi.org/10.1128/jvi.00250-12

Burke, C. T., Cullen, J. M., State, A., Gadi, S., Wilber, K., Rosenthal, M., … Fuchs, H. (2011). Development of an Animal Model for Radiofrequency Ablation of Primary, Virally Induced Hepatocellular Carcinoma in the Woodchuck. JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 22(11), 1613–1618. https://doi.org/10.1016/j.jvir.2011.08.020

Cullen, J. M., Williams, C., Zadrozny, L., Otstot, J. T., Solomon, G. G., Sills, R. C., & Hong, H.-H. L. (2011). H-ras Consensus Sequence and Mutations in Primary Hepatocellular Carcinomas of Lemurs and Lorises. VETERINARY PATHOLOGY, 48(4), 868–874. https://doi.org/10.1177/0300985810388526

Hedan, B., Thomas, R., Motsinger-Reif, A., Abadie, J., Andre, C., Cullen, J., & Breen, M. (2011). Molecular cytogenetic characterization of canine histiocytic sarcoma: A spontaneous model for human histiocytic cancer identifies deletion of tumor suppressor genes and highlights influence of genetic background on tumor behavior. BMC Cancer, 11.

Law, M., Stromberg, P., Meuten, D., & Cullen, J. (2011). Necropsy or Autopsy? It’s All About Communication! Veterinary Pathology, 49(2), 271–272. https://doi.org/10.1177/0300985811410722

Kamstock, D. A., Ehrhart, E. J., Getzy, D. M., Bacon, N. J., Rassnick, K. M., Moroff, S. D., … Foster, R. A. (2011). Recommended guidelines for submission, trimming, margin evaluation, and reporting of tumor biopsy specimens in veterinary surgical pathology. Veterinary Pathology, 48(1), 19–31.

Webster, J. D., Dennis, M. M., Dervisis, N., Heller, J., Bacon, N. J., Bergman, P. J., … Kamstock, D. (2011). Recommended guidelines for the conduct and evaluation of prognostic studies in veterinary oncology. Veterinary Pathology, 48(1), 7–18.

Faiola, B., Peterson, R. A., Kimbrough, C. L., Jordan, H. L., & Cullen, J. M. (2010). Acute ANIT Toxicity in Male IL-10 Knockout and Wild-type Mice. TOXICOLOGIC PATHOLOGY, 38(5), 745–755. https://doi.org/10.1177/0192623310374970

Brown, D. L., Van Winkle, T., Cecere, T., Rushton, S., Brachelente, C., & Cullen, J. M. (2010). Congenital Hepatic Fibrosis in 5 Dogs. VETERINARY PATHOLOGY, 47(1), 102–107. https://doi.org/10.1177/0300985809353313

Asakawa, M. G., Mackillop, E., Olby, N. J., Robertson, I. D., & Cullen, J. M. (2010). Imaging diagnosis-neuronal ceroid lipofuscinosis with a chronic subdural hematoma. Veterinary Radiology & Ultrasound, 51(2), 155–158.

Zadrozny, L. M., Williams, C. V., Remick, A. K., & Cullen, J. M. (2010). Spontaneous Hepatocellular Carcinoma in Captive Prosimians. VETERINARY PATHOLOGY, 47(2), 306–311. https://doi.org/10.1177/0300985809359380

Cullen, J. M., Falls, J. G., Brown, H. R., Yoon, L. W., Cariello, N. F., Faiola, B., … Miller, R. T. (2010). Time Course Gene Expression Using Laser Capture Microscopy-Extracted Bile Ducts, but Not Hepatic Parenchyma, Reveals Acute Alpha-Naphthylisothiocyanate Toxicity. TOXICOLOGIC PATHOLOGY, 38(5), 715–729. https://doi.org/10.1177/0192623310373774

Tuttle, A. D., MacLean, R. A., Linder, K., Cullen, J. M., Wolfe, B. A., & Loomis, M. (2009). ACQUIRED ARTERIOVENOUS FISTULA IN A GRIZZLY BEAR (URSUS ARCTOS HORRIBILIS). JOURNAL OF ZOO AND WILDLIFE MEDICINE, 40(1), 193–195. https://doi.org/10.1638/2007-0030.1

Cullen, J. M., Brown, D. L., Kissling, G. E., Foley, J. F., Rizzo, J., Marion, P. L., … French, J. E. (2009). Aflatoxin B1 and/or Hepatitis B Virus Induced Tumor Spectrum in a Genetically Engineered Hepatitis B Virus Expression and Trp53 Haploinsufficient Mouse Model System for Hepatocarcinogenesis. TOXICOLOGIC PATHOLOGY, 37(3), 333–342. https://doi.org/10.1177/0192623309333137

Thomas, R., Valli, V. E., Ellis, P., Bell, J., Karlsson, E. K., Cullen, J., … Breen, M. (2009). Microarray-based cytogenetic profiling reveals recurrent and subtype-associated genomic copy number aberrations in feline sarcomas. CHROMOSOME RESEARCH, 17(8), 987–1000. https://doi.org/10.1007/s10577-009-9096-0

Cullen, J. M. (2009). Summary of the World Small Animal Veterinary Association Standardization Committee Guide to Classification of Liver Disease in Dogs and Cats. VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE, 39(3), 395-+. https://doi.org/10.1016/j.cvsm.2009.02.003

Macias, E., Marva, P. L. M., Senderowicz, A., Cullen, J., & Rodriguez-Puebla, M. L. (2008). Expression of CDK4 or CDK2 in mouse oral cavity is retained in adult pituitary with distinct effects on tumorigenesis. CANCER RESEARCH, 68(1), 162–171. https://doi.org/10.1158/0008-5472.CAN-07-2461

Ranck, R. S., Cullen, J. M., Waggie, K. S., & Marion, P. L. (2008). Harderian gland neoplasms in captive, wild-caught Beechey ground squirrels (Spermophilus beecheyi). VETERINARY PATHOLOGY, 45(3), 388–392. https://doi.org/10.1354/vp.45-3-388

Cullen, J. M., Lindsey-Pegram, D., & Cote, P. J. (2008). Serologic survey of woodchuck hepatitis virus in North Carolina woodchucks (Marmota monax). JOURNAL OF ZOO AND WILDLIFE MEDICINE, 39(2), 263–265. https://doi.org/10.1638/2007-0119R.1

Hess, P. R., Barnes, C., Woolard, M. D., Johnson, M. D. L., Cullen, J. M., Collins, E. J., & Frelinger, J. A. (2007). Selective deletion of antigen-specific CD8(+) T cells by MHC class I tetramers, coupled to the type I ribosome-inactivating protein saporin. BLOOD, 109(8), 3300–3307. https://doi.org/10.1182/blood-2006-06-028001

Xu, C., Yamamoto, T., Zhou, T., Aldrich, C. E., Frank, K., Cullen, J. M., … Mason, W. S. (2007). The liver of woodchucks chronically infected with the woodchuck hepatitis virus contains foci of virus core antigen-negative hepatocytes with both altered and normal morphology. VIROLOGY, 359(2), 283–294. https://doi.org/10.1016/j.virol.2006.09.034

Johnson, A. L., Divers, T. J., Freckleton, M. L., McKenzie, H. C., Mitchell, E., Cullen, J. M., & McDonough, S. P. (2006). Fall panicum (Panicum dichotomiflorum) hepatotoxicosis in horses and sheep. JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 20, pp. 1414–1421. https://doi.org/10.1892/0891-6640(2006)20[1414:FPPDHI]2.0.CO;2

Xu, C., Yamamoto, T., Zhou, T., Aldrich, C., Cullen, J. M., Jilbert, A. R., & Mason, W. S. (2006). P.050 Appearance of core antigen negative hepatocytes in woodchucks chronically infected with woodchuck hepatitis virus. Journal of Clinical Virology, 36, S76. https://doi.org/10.1016/S1386-6532(06)80233-7

Cullen, J. M., & Miller, R. T. (2006). [Review of The role of pathology in the identification of drug-induced hepatic toxicity]. EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 2(2), 241–247. https://doi.org/10.1517/17425255.2.2.241

Hajjou, M., Norel, R., Carver, R., Marion, P., Cullen, J., Rogler, L. E., & Rogler, C. E. (2005). CDNA microarray analysis of HBV transgenic mouse liver identifies genes in lipid biosynthetic and growth control pathways affected by HBV. JOURNAL OF MEDICAL VIROLOGY, 77(1), 57–65. https://doi.org/10.1002/jmv.20427

Cullen, J. M. (2005). Mechanistic Classification of Liver Injury. Toxicologic Pathology, 33(1), 6–8. https://doi.org/10.1080/01926230590522428

Elmore, S. A., Basseches, J., Anhalt, G. J., Cullen, J. M., & Olivry, T. (2005). Paraneoplastic pemphigus in a dog with splenic sarcoma. VETERINARY PATHOLOGY, 42(1), 88–91. https://doi.org/10.1354/vp.42-1-88

Zhu, Y., Cullen, J. M., Aldrich, C. E., Saputelli, J., Miller, D., Seeger, C., … Jilbert, A. R. (2004). Adenovirus-based gene therapy during clevudine treatment of woodchucks chronically infected with woodchuck hepatitis virus. VIROLOGY, 327(1), 26–40. https://doi.org/10.1016/j.virol.2004.06.017

Li, D. H., Kumanogoh, A., Cao, T. M., Parnes, JR, & Cullen, J. M. (2004). Woodchuck interleukin-6 gene: structure,characterization, and biologic activity. GENE, 342(1), 157–164. https://doi.org/10.1016/j.gene.2004.07.034

Gillespie, T. N., Washabau, R. J., Goldschmidt, M. H., Cullen, J. M., Rogala, A. R., & Breitschwerdt, E. B. (2003). Detection of Bartonella henselae and Bartonella clarridgeiae DNA in hepatic specimens from two dogs with hepatic disease. Journal of the American Veterinary Medical Association, 222(1), 47–51. https://doi.org/10.2460/javma.2003.222.47

Fox, J. G., Shen, Z. L., Xu, S. L., Feng, Y., Dangler, C. A., Dewhirst, F. E., … Cullen, J. M. (2002). Helicobacter marmotae sp nov isolated from livers of woodchucks and intestines of cats. JOURNAL OF CLINICAL MICROBIOLOGY, 40(7), 2513–2519. https://doi.org/10.1128/JCM.40.7.2513-2519.2002

Cullen, J. M., Ll, D. H., Brown, C., Eisenberg, E. J., Cundy, K. C., Wolfe, J., … Gibbs, C. (2001). Antiviral efficacy and pharmacokinetics of oral adefovir dipivoxil in chronically woodchuck hepatitis virus-infected woodchucks. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 45(10), 2740–2745. https://doi.org/10.1128/AAC.45.10.2740-2745.2001

Bunch, S. E., Johnson, S. E., & Cullen, J. M. (2001, February 1). Idiopathic noncirrhotic portal hypertension in dogs: 33 cases (1982-1998). JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 218, pp. 392–399. https://doi.org/10.2460/javma.2001.218.392

Zhu, Y., Yamamoto, T., Cullen, J., Saputelli, J., Aldrich, C. E., Miller, D. S., … Mason, W. S. (2001). Kinetics of hepadnavirus loss from the liver during inhibition of viral DNA synthesis. JOURNAL OF VIROLOGY, 75(1), 311–322. https://doi.org/10.1128/JVI.75.1.311-322.2001

Hervas-Stubbs, S., Lasarte, J. J., Sarobe, P., Vivas, I., Condreay, L., Cullen, J. M., … Borras-Cuesta, F. (2001). T-helper cell response to woodchuck hepatitis virus antigens after therapeutic vaccination of chronically-infected animals treated with lamivudine. JOURNAL OF HEPATOLOGY, 35(1), 105–111. https://doi.org/10.1016/S0168-8278(01)00063-0

Ohashi, K., Marion, P. L., Nakai, H., Meuse, L., Cullen, J. M., Bordier, B. B., … Kay, M. A. (2000). Sustained survival of human hepatocytes in mice: A model for in vivo infection with human hepatitis B and hepatitis delta viruses. Nature Medicine, 6(3), 327–331. https://doi.org/10.1038/73187

Li, D. H., Havell, E. A., Brown, C. L., & Cullen, J. M. (2000). Woodchuck lymphotoxin-alpha, -beta and tumor necrosis factor genes: structure, characterization and biological activity. GENE, 242(1-2), 295–305. https://doi.org/10.1016/S0378-1119(99)00494-1

Sharp, N. J. H., Davis, B. J., Guy, J. S., Cullen, J. M., Steingold, S. F., & Kornegay, J. N. (1999). Hydranencephaly and cerebellar hypoplasia in two kittens attributed to intrauterine parvovirus infection. JOURNAL OF COMPARATIVE PATHOLOGY, 121(1), 39–53. https://doi.org/10.1053/jcpa.1998.0298

Mason, W. S., Cullen, J., Moraleda, G., Saputelli, J., Aldrich, C. E., Miller, D. S., … Jilbert, A. R. (1998). Lamivudine therapy of WHV-infected woodchucks. VIROLOGY, 245(1), 18–32. https://doi.org/10.1006/viro.1998.9150

Cullen, J. M., Smith, S. L., Davis, M. G., Dunn, S. E., Botteron, C., Cecchi, A., … Biron, K. (1997). In vivo antiviral activity and pharmacokinetics of (-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine in woodchuck hepatitis virus-infected woodchucks. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 41(10), 2076–2082. https://doi.org/10.1128/aac.41.10.2076

HervasStubbs, S., Lasarte, J. J., Sarobe, P., Prieto, J., Cullen, J., Roggendorf, M., & BorrasCuesta, F. (1997). Therapeutic vaccination of woodchucks against chronic woodchuck hepatitis virus infection. JOURNAL OF HEPATOLOGY, 27(4), 726–737. https://doi.org/10.1016/S0168-8278(97)80090-6

CULLEN, J. M., SANDGREN, E. P., BRINSTER, R. L., & MARONPOT, R. R. (1993). HISTOLOGIC CHARACTERIZATION OF HEPATIC CARCINOGENESIS IN TRANSGENIC MICE EXPRESSING SV40 T-ANTIGENS. VETERINARY PATHOLOGY, 30(2), 111–118. https://doi.org/10.1177/030098589303000203

Cullen, J. M., Marion, P. L., Sherman, G. J., Hong, X., & Newbold, J. E. (1990). Hepatic neoplasms in aflatoxin B1-treated, congenital duck hepatitis B virus-infected, and virus-free Pekin ducks. Cancer Research, 50(13), 4072.

Cullen, J., & Levine, J. F. (1987). Pathologic manifestations of experimental Babesia microti infection in hamsters. Laboratory Animal Science, 37, 640–643.

Shearin, A. L., Hedan, B., Cadieu, E., Erich, S. A., Schmidt, E. V., Faden, D. L., … Andre, C. The MTAP-CDKN2A locus confers susceptibility to a naturally occurring canine cancer. Cancer Epidemiology Biomarkers, 21(7), 1019–1027.