Jennifer D'Antonio

Works (10)

Updated: July 25th, 2023 21:14

2022 article

Mössbauer studies of the ferryl, ferrous and ferric states of dehaloperoxidase from A. ornata

Popescu, C. V., Dinh, T., Chen, H., Miller, D., Washburn, A., McGuire, A., … Ghiladi, R. A. (2022, May 25). Journal of Inorganic Biochemistry, Vol. 234.

By: C. Popescu, T. Dinh *, H. Chen *, D. Miller*, A. Washburn*, A. McGuire  n, R. Dumarieh n, J. D'Antonio n, R. Ghiladi* 

author keywords: Mossbauer spectroscopy; Peroxidase; Heme enzyme; Ferryl; Globin
MeSH headings : Animals; Ferric Compounds / chemistry; Heme / chemistry; Hemoglobins / chemistry; Hydrogen Peroxide / chemistry; Iron / chemistry; Myoglobin / chemistry; Peroxidases / metabolism; Polychaeta; Spectroscopy, Mossbauer
topics (OpenAlex): Hemoglobin structure and function; Porphyrin Metabolism and Disorders; Erythrocyte Function and Pathophysiology
TL;DR: The isomer shift and quadrupole splitting of DHP in the four states studied are expectedly similar to both peroxidases and to myoglobin, and differences in electronic structure between DHP and other heme proteins and enzyme are observed in the high-field Mössbauer spectra of the ferric state, which show pH-dependent zero-field splittings suggesting a heme site in which the ligand field strength at the iron ion is tuned by pH. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: December 12, 2022

2016 journal article

Nonmicrobial Nitrophenol Degradation via Peroxygenase Activity of Dehaloperoxidase-Hemoglobin fromAmphitrite ornata

Biochemistry, 55(17), 2465–2478.

By: N. McCombs n, J. D’Antonio n, D. Barrios n, L. Carey n & R. Ghiladi n 

Contributors: N. McCombs n, . J. D'Antonio n, D. Barrios n, L. Carey n & R. Ghiladi n 

MeSH headings : Animals; Catalysis; Hemoglobins / metabolism; Hydrogen Peroxide / metabolism; Mixed Function Oxygenases / metabolism; Nitrophenols; Oxidation-Reduction; Oxygen / metabolism; Peroxidases / metabolism; Polychaeta / enzymology
topics (OpenAlex): Hemoglobin structure and function; Heme Oxygenase-1 and Carbon Monoxide; Metal-Catalyzed Oxygenation Mechanisms
TL;DR: The results demonstrate that there may be a much larger number of nonmicrobial enzymes that are underrepresented when it comes to understanding the degradation of persistent organic pollutants such as nitrophenols in the environment. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2014 article

Comparability of Higher Order Structure in Proteins: Chemometric Analysis of Second-Derivative Amide I Fourier Transform Infrared Spectra

Stockdale, G., Murphy, B. M., D'Antonio, J., Manning, M. C., & Al-Azzam, W. (2014, November 7). Journal of Pharmaceutical Sciences.

By: G. Stockdale*, B. Murphy *, J. D'Antonio n, M. Manning * & W. Al-Azzam*

author keywords: protein structure; FTIR; spectroscopy; proteins; chemometrics; biopharmaceuticals characterization; stability
MeSH headings : Algorithms; Analytic Sample Preparation Methods; Animals; Chemistry, Pharmaceutical / methods; Chickens; Computational Biology; Horses; Humans; Hydrogen-Ion Concentration; Immunoglobulin G / chemistry; Models, Molecular; Muramidase / chemistry; Myoglobin / chemistry; Principal Component Analysis; Protein Conformation; Protein Unfolding; Spectroscopy, Fourier Transform Infrared; Temperature
topics (OpenAlex): Spectroscopy and Chemometric Analyses; Spectroscopy Techniques in Biomedical and Chemical Research; Metabolomics and Mass Spectrometry Studies
TL;DR: Chemometric analyses of the same data were performed, to classify samples into different groups based on the solution conditions received, and the DModX values were found to be a more sensitive quantitative indicator of changes in HOS, when compared with the modified area of overlap algorithm. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2014 journal article

Peroxygenase and Oxidase Activities of Dehaloperoxidase-Hemoglobin from Amphitrite ornata

Journal of the American Chemical Society, 136(22), 7914–7925.

By: D. Barrios n, J. D’Antonio n, N. McCombs n, J. Zhao n, S. Franzen n , A. Schmidt n, L. Sombers n , R. Ghiladi n 

Contributors: D. Barrios n, . J. D'Antonio n, N. McCombs n, J. Zhao n, S. Franzen n , A. Schmidt n, L. Sombers n , R. Ghiladi n 

MeSH headings : Animals; Catalytic Domain; Hemoglobins / chemistry; Hemoglobins / metabolism; Indoles / chemistry; Indoles / metabolism; Mixed Function Oxygenases / metabolism; Models, Molecular; Oxidoreductases / metabolism; Oxygen / chemistry; Oxygen Consumption; Oxygen Radioisotopes; Polychaeta / enzymology; Protein Conformation
topics (OpenAlex): Hemoglobin structure and function; Heme Oxygenase-1 and Carbon Monoxide; Metal-Catalyzed Oxygenation Mechanisms
TL;DR: The marine globin dehaloperoxidase‐hemoglobin (DHP) from Amphitrite ornata was found to catalyze the H2O2‐dependent oxidation of monohaloindoles, a previously unreported class of substrate for DHP, and non‐enzymatic and anaerobic controls suggest a novel oxidase activity for D HP. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2014 article

Use of the Amide II Infrared Band of Proteins for Secondary Structure Determination and Comparability of Higher Order Structure

Murphy, B. M., D'Antonio, J., Manning, M. C., & Al-Azzam, W. (2014, October 15). Current Pharmaceutical Biotechnology.

By: B. Murphy, J. D'Antonio*, M. Manning & W. Al-Azzam*

author keywords: Amide I; Amide II; chemometrics; formulation development; FTIR; higher order structure; therapeutic proteins; secondary structure
MeSH headings : Algorithms; Amides / chemistry; Caseins / chemistry; Immunoglobulin G / chemistry; Muramidase / chemistry; Myoglobin / chemistry; Principal Component Analysis; Protein Structure, Secondary; Spectroscopy, Fourier Transform Infrared
topics (OpenAlex): Enzyme Production and Characterization; Protein Structure and Dynamics; Biochemical effects in animals
TL;DR: Spectral overlap and spectral correlation coefficients results show strong correlations between changes in the second derivative of amide II and amide I FTIR spectra for various model proteins under different conditions, which demonstrate the applicability of using amid II FTIR Spectra for the comparability of protein secondary structure. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2012 article

Comparability of Protein Therapeutics: Quantitative Comparison of Second-Derivative Amide I Infrared Spectra

D'antonio, J., Murphy, B. M., Manning, M. C., & Al-azzam, W. A. (2012, March 24). Journal of Pharmaceutical Sciences.

By: J. D'antonio n, B. Murphy *, M. Manning * & W. Al-azzam*

author keywords: Biopharmaceuticals characterization; FTIR; protein structure; structure; proteins; higher order structures; comparability studies; area overlap; secondary structure; spectral correlation coefficient
MeSH headings : Algorithms; Amides / chemistry; Hydrogen-Ion Concentration; Proteins / chemistry; Proteins / therapeutic use; Spectroscopy, Fourier Transform Infrared / methods; Temperature
topics (OpenAlex): Protein purification and stability; Viral Infectious Diseases and Gene Expression in Insects; Drug Solubulity and Delivery Systems
TL;DR: In this study, the two most common methods, spectral correlation coefficient and area of overlap (AO) are compared for their ability to determine spectral comparability of a protein as a function of changes in pH or temperature. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2011 journal article

Functional Consequences of the Creation of an Asp-His-Fe Triad in a 3/3 Globin

Biochemistry, 50(44), 9664–9680.

By: E. D’Antonio n, J. D’Antonio n, V. de Serrano n, H. Gracz n, M. Thompson n, R. Ghiladi n , E. Bowden n , S. Franzen n 

Contributors: E. Dantonio n, J. Dantonio n, V. De Serrano n, H. Gracz n, M. Thompson n, R. Ghiladi n , E. Bowden n , S. Franzen n 

MeSH headings : Animals; Aspartic Acid / chemistry; Aspartic Acid / genetics; Catalytic Domain / genetics; Crystallography, X-Ray; Electrochemistry; Globins / chemistry; Globins / genetics; Helminth Proteins / chemistry; Helminth Proteins / genetics; Histidine / chemistry; Histidine / genetics; Magnetic Resonance Spectroscopy; Mutagenesis, Site-Directed; Polychaeta / enzymology; Polychaeta / genetics; Spectrophotometry, Ultraviolet; Spectrum Analysis, Raman
topics (OpenAlex): Hemoglobin structure and function; Metalloenzymes and iron-sulfur proteins; Enzyme Structure and Function
TL;DR: The results suggest that the proximal charge relay in peroxidases regulate the redox potential of the heme Fe but that the trans effect is a carefully balanced property that can both activate H( 2)O(2) and attract ligation by the distal histidine. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2011 journal article

Reactivity of Deoxy- and Oxyferrous Dehaloperoxidase B fromAmphitrite ornata:Identification of Compound II and Its Ferrous–Hydroperoxide Precursor

Biochemistry, 50(27), 5999–6011.

By: J. D’Antonio n & R. Ghiladi n 

Contributors: J. Dantonio n & R. Ghiladi n 

MeSH headings : Animals; Electron Spin Resonance Spectroscopy; Enzyme Precursors / chemistry; Enzyme Precursors / metabolism; Ferric Compounds / chemistry; Ferric Compounds / metabolism; Ferrous Compounds / chemistry; Ferrous Compounds / metabolism; Hydrogen Peroxide / chemistry; Hydrogen Peroxide / metabolism; Isoenzymes / chemistry; Isoenzymes / metabolism; Peroxidases / chemistry; Peroxidases / metabolism; Polychaeta / enzymology; Spectrophotometry, Ultraviolet
topics (OpenAlex): Hemoglobin structure and function; Vanadium and Halogenation Chemistry; Metal-Catalyzed Oxygenation Mechanisms
TL;DR: The data presented herein provide a link between the peroxidase and oxygen transport activities, which furthers the understanding of how this bifunctional enzyme is able to unite its two inherent functions in one system. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2010 journal article

Spectroscopic and Mechanistic Investigations of Dehaloperoxidase B fromAmphitrite ornata

Biochemistry, 49(31), 6600–6616.

By: J. D’Antonio n, E. D’Antonio n, M. Thompson n, E. Bowden n , S. Franzen n , T. Smirnova n , R. Ghiladi n 

Contributors: . J. D'Antonio n, . E.L. D'Antonio n, M. Thompson n, E. Bowden n , S. Franzen n , T. Smirnova n , R. Ghiladi n 

MeSH headings : Animals; Cloning, Molecular; Halogenation; Hemoglobins; Iron; Kinetics; Oxidation-Reduction; Oxygen / metabolism; Peroxidases / genetics; Peroxidases / metabolism; Polychaeta / enzymology; Spectrum Analysis
topics (OpenAlex): Hemoglobin structure and function; Heme Oxygenase-1 and Carbon Monoxide; Photosynthetic Processes and Mechanisms
TL;DR: A novel reaction pathway is demonstrated in which the products of the oxidative dehalogenation of trihalophenols (dihaloquinones) are themselves capable of inducing formation of oxyferrous DHP B, and an updated catalytic cycle for DHP is proposed. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2010 journal article

Structure of dehaloperoxidase B at 1.58 angstrom resolution and structural characterization of the AB dimer from Amphitrite ornata

Acta Crystallographica. Section D, Biological Crystallography, 66, 529–538.

By: V. Serrano, J. D'Antonio, S. Franzen  & R. Ghiladi 

Source: NC State University Libraries
Added: August 6, 2018

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