James D Brooks

Works (51)

Updated: April 4th, 2024 18:53

2018 journal article

Genetic Parameter Estimates for Metabolizing Two Common Pharmaceuticals in Swine

Frontiers in Genetics, 9(FEB).

By: J. Howard  n, M. Ashwell n, R. Baynes n, J. Brooks n, J. Yeatts n & C. Maltecca n 

Contributors: J. Howard  n, M. Ashwell n, R. Baynes n, J. Brooks n, J. Yeatts n & C. Maltecca n 

author keywords: swine; pharmacogenomics; heritability; fenbendazole; flunixin meglumine
TL;DR: A low to moderate proportion of the phenotypic variation in metabolizing fenbendazole and flunixin meglumine drug metabolism was explained by genetics in the current study. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018

2017 journal article

Gene co-expression network analysis identifies porcine genes associated with variation in metabolizing fenbendazole and flunixin meglumine in the liver

Scientific Reports, 7(1).

By: J. Howard n, M. Ashwell n, R. Baynes n, J. Brooks n, J. Yeatts n & C. Maltecca n 

Contributors: J. Howard n, M. Ashwell n, R. Baynes n, J. Brooks n, J. Yeatts n & C. Maltecca n 

MeSH headings : Animals; Antinematodal Agents / pharmacokinetics; Clonixin / analogs & derivatives; Clonixin / pharmacokinetics; Female; Fenbendazole / pharmacokinetics; Gene Expression; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Liver / drug effects; Liver / metabolism; Male; Sus scrofa / genetics; Transcriptome
TL;DR: The objective was to identify individual genes and gene networks involved in metabolizing fenbendazole (FBZ) and flunixin meglumine (FLU) in swine liver to allow for greater insight into FBZ and FLU metabolism. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018

2017 journal article

Pharmacokinetics of C-14-ortho-phenylphenol following intravenous administration in pigs

JOURNAL OF APPLIED TOXICOLOGY, 37(4), 508–512.

By: E. Nixon n , J. Brooks n, P. Routh n, J. Chittenden* & R. Baynes n

author keywords: pharmacokinetics; ortho-phenylphenol; intravenous dose; pig; biocide
MeSH headings : Administration, Intravenous; Animals; Area Under Curve; Biphenyl Compounds / administration & dosage; Biphenyl Compounds / pharmacokinetics; Disinfectants / pharmacokinetics; Feces / chemistry; Half-Life; Male; Sus scrofa; Swine; Tissue Distribution
TL;DR: Comparisons with other species suggest that 14C‐OPP clearance in pigs (2.48 ml h–1 kg–1) is less than that in humans and rats and that the kidneys play a crucial role in clearance with a large percentage of the dose being found in the urine. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

Skin absorption of six performance amines used in metalworking fluids

JOURNAL OF APPLIED TOXICOLOGY, 35(5), 520–528.

By: L. Roux *, J. Brooks n, J. Yeatts n & R. Baynes n

author keywords: skin absorption; metalworking fluids; flow-through diffusion cell; ethanolamines; biocide
MeSH headings : Amines / pharmacokinetics; Animals; Cyclohexylamines / pharmacokinetics; Diphenylamine / pharmacokinetics; Disinfectants / pharmacokinetics; Ethanolamine / pharmacokinetics; Ethanolamines / pharmacokinetics; Gas Chromatography-Mass Spectrometry; Linear Models; Metallurgy; Permeability; Skin Absorption / drug effects; Swine
TL;DR: To determine the absorption of six amines used as corrosion inhibitors and biocides in MWFs, porcine skin flow‐through diffusion cell experiments were conducted and results should help MWF industries choose safer additives for their formulations to protect the health of metalworkers. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Development of a Mixed-Effect Pharmacokinetic Model for Vehicle Modulated In Vitro Transdermal Flux of Topically Applied Penetrants

JOURNAL OF PHARMACEUTICAL SCIENCES, 103(3), 1002–1012.

By: J. Chittenden n, J. Brooks n & J. Riviere*

author keywords: transdermal drug delivery; skin; passive diffusion; transport; mathematical model; in vitro models; formulation vehicle; diffusion
MeSH headings : Administration, Cutaneous; Algorithms; Animals; Diffusion; Dimethylpolysiloxanes / chemistry; In Vitro Techniques; Models, Biological; Pharmaceutical Preparations / administration & dosage; Pharmaceutical Preparations / analysis; Pharmaceutical Preparations / chemistry; Pharmaceutical Vehicles / chemistry; Pharmacokinetics; Reproducibility of Results; Skin Absorption; Sus scrofa
TL;DR: A mixed effects modeling framework was used so that models can be estimated with as few parameters as possible, while also quantifying variability and accounting for correlation in the data. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2014 journal article

In silico models to predict dermal absorption from complex agrochemical formulations

SAR AND QSAR IN ENVIRONMENTAL RESEARCH, 25(7), 565–588.

By: K. Guth n, J. Riviere n, J. Brooks n, M. Dammann*, E. Fabian*, B. Ravenzwaay*, M. Schaefer-Korting, R. Landsiedel*

author keywords: dermal absorption; mixture; quantitative structure permeability relationship (QSPR); risk assessment; agrochemicals
MeSH headings : Agrochemicals / pharmacokinetics; Animals; Complex Mixtures / pharmacokinetics; Computer Simulation; Humans; Linear Models; Models, Biological; Quantitative Structure-Activity Relationship; Rats; Skin / metabolism; Skin Absorption
TL;DR: Application of this in silico prediction model would reduce animal and non-animal testings when used for the optimization of formulations in early developmental stages, or would simplify the registration process, if accepted for read-across. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Prediction of formulation effects on dermal absorption of topically applied ectoparasiticides dosed in vitro on canine and porcine skin using a mixture-adjusted quantitative structure permeability relationship

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 37(5), 435–444.

By: J. Riviere n, J. Brooks n, W. Collard*, J. Deng *, G. Rose*, S. Mahabir*, D. Merritt*, A. Marchiondo*

MeSH headings : Administration, Topical; Animals; Chemical Phenomena; Dogs; Insecticides / pharmacokinetics; Models, Biological; Permeability; Skin / drug effects; Skin Absorption / physiology; Swine; Tissue Culture Techniques
TL;DR: These studies clearly showed that the permeation of topical ectoparasiticides could be well predicted using QSPeR models that account for both the physical-chemical properties of the penetrant and formulation components. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Tetracycline Residues in Porcine Stomach after Administration via Drinking Water on a Swine Farm

JOURNAL OF FOOD PROTECTION, 77(1), 122–126.

By: D. Lindquist n, H. Wu *, S. Mason*, J. Yeatts n, J. Brooks n, B. Barlow n, K. Schill n, R. Baynes n

MeSH headings : Animals; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Chromatography, High Pressure Liquid / veterinary; Drug Residues / analysis; Europe; Meat / analysis; Monte Carlo Method; Russia; Stomach / chemistry; Swine; Tetracycline / blood; Tetracycline / pharmacokinetics; United States; Water / chemistry
TL;DR: It is demonstrated that tetracycline residues are still detectable in the stomach tissues after the established United States withdrawal time of 4 days, which may explain why stomach tissues tested in Russia and Europe show positive residues for tetrACYcline, even though the meat may pass inspection here in the United States prior to export. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

The effect of breed and sex on sulfamethazine, enrofloxacin, fenbendazole and flunixin meglumine pharmacokinetic parameters in swine

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 37(6), 531–541.

By: J. Howard  n, R. Baynes n, J. Brooks n, J. Yeatts n, B. Bellis n, M. Ashwell n, P. Routh n, A. O'Nan n, C. Maltecca n 

Contributors: J. Howard  n, R. Baynes n, J. Brooks n, J. Yeatts n, B. Bellis n, M. Ashwell n, P. Routh n, . A.T. O'Nan n, C. Maltecca n 

MeSH headings : Animals; Anti-Infective Agents / blood; Anti-Infective Agents / pharmacokinetics; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Antinematodal Agents / blood; Antinematodal Agents / pharmacokinetics; Benzimidazoles / blood; Ciprofloxacin / blood; Clonixin / analogs & derivatives; Clonixin / blood; Clonixin / pharmacokinetics; Enrofloxacin; Female; Fenbendazole / blood; Fenbendazole / pharmacokinetics; Fluoroquinolones / blood; Fluoroquinolones / pharmacokinetics; Male; Sex Factors; Species Specificity; Sulfamethazine / analogs & derivatives; Sulfamethazine / blood; Sulfamethazine / pharmacokinetics; Swine / metabolism
TL;DR: Whether drug clearance differs across genetic backgrounds and sex for sulfamethazine, enrofloxacin, fenbendazole and flunixin meglumine is determined to determine the degree of additive genetic variation utilizing a larger population. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2013 journal article

Modeling the effect of experimental variables on the in vitro permeation of six model compounds across porcine skin

International Journal of Pharmaceutics, 443(1-2), 58–67.

By: D. Karadzovska n, J. Brooks n & J. Riviere*

author keywords: Quantitative structure-permeability; relationships (QSPeRs); Experimental variables; Mixture factor; Steady-state flux; Percutaneous absorption
MeSH headings : Animals; Drug Carriers; Female; Hydrogen Bonding; In Vitro Techniques; Models, Biological; Permeability; Pharmaceutical Preparations / administration & dosage; Pharmaceutical Preparations / metabolism; Quantitative Structure-Activity Relationship; Regression Analysis; Skin / metabolism; Skin Absorption; Swine
TL;DR: Development and statistical validation of QSPeR models that incorporate the effects of penetrant, vehicle, and experimental conditions such as dose volume (finite/infinite), and saturation level (saturated/unsaturated). (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2013 journal article

Predicting skin permeability from complex chemical mixtures: incorporation of an expanded QSAR model

SAR and QSAR in Environmental Research, 24(9), 711–731.

By: G. Xu n, J. Hughes-Oliver*, J. Brooks n & R. Baynes n

author keywords: Abraham's LFER model; adjusted Q(LOO)(2); expanded LFER model; leave-one-solute-out; QSAR
MeSH headings : Complex Mixtures / pharmacokinetics; Permeability; Quantitative Structure-Activity Relationship; Skin / drug effects
TL;DR: An expanded QSAR model is proposed in which one set of partial slopes is defined for each experimental condition, where conditions are defined according to solvent: water, synthetic oil, semi-synthetic oil, or soluble oil, which improved both the model fit and the predictive power when compared with the simple model. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref
Added: August 6, 2018

2013 review

Predicting skin permeability from complex vehicles

[Review of ]. ADVANCED DRUG DELIVERY REVIEWS, 65(2), 265–277.

By: D. Karadzovska n, J. Brooks n, N. Monteiro-Riviere n  & J. Riviere n

Contributors: D. Karadzovska n, J. Brooks n, N. Monteiro-Riviere n  & J. Riviere n

author keywords: Chemical mixtures; Formulations; Percutaneous/dermal absorption; Quantitative structure-permeation relationship (QSPR); QSAR; Linear free energy relationships (LFER); Mixture factor; Topical drug delivery enhancers
MeSH headings : Animals; Drug Delivery Systems; Humans; Linear Energy Transfer; Models, Theoretical; Permeability; Pharmaceutical Preparations / administration & dosage; Pharmaceutical Preparations / metabolism; Pharmaceutical Vehicles / chemistry; Quantitative Structure-Activity Relationship; Skin / metabolism; Skin Absorption
TL;DR: This review highlights the progress made in predicting skin permeability from complex vehicles by extending the use of quantitative structure-permeation relationship (QSPR) models based on linear free energy relationships (LFER) to predict dermal absorption from complex mixtures with the inclusion of significant molecular descriptors such as a mixture factor. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2013 journal article

Selection of appropriate training and validation set chemicals for modelling dermal permeability by U-optimal design

SAR and QSAR in Environmental Research, 24(2), 135–156.

By: G. Xu n, J. Hughes-Oliver*, J. Brooks n, J. Yeatts n & R. Baynes n

author keywords: QSAR model; training set selection; Baynes' Rule; U-optimal design; principal component analysis (PCA); applicability domain (AD)
MeSH headings : Chemistry / methods; Inorganic Chemicals / chemistry; Inorganic Chemicals / pharmacokinetics; Models, Statistical; Organic Chemicals / chemistry; Organic Chemicals / pharmacokinetics; Permeability; Quantitative Structure-Activity Relationship; Skin / drug effects
TL;DR: This paper describes a comprehensive procedure to select training sets from a large candidate set of 4534 solutes, using the newly proposed ‘Baynes’ rule’, which is a modification of Lipinski's ‘rule of five’ to screen out solutes that were not qualified for the study. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref
Added: August 6, 2018

2012 journal article

Acute vascular effects of nanoparticle infusion in isolated perfused skin

Nanomedicine: Nanotechnology, Biology and Medicine, 8(4), 428–431.

By: J. Riviere n, T. Leavens n , J. Brooks n & N. Monteiro-Riviere n 

Contributors: J. Riviere n, T. Leavens n , J. Brooks n & N. Monteiro-Riviere n 

author keywords: Nanoparticles; Vascular toxicity; In vitro; Biodistribution
MeSH headings : Animals; Female; Perfusion; Quantum Dots; Skin / blood supply; Skin / pathology; Skin / physiopathology; Sus scrofa; Vascular Resistance / drug effects
TL;DR: Specific nanoparticle infusions were demonstrated to be associated with significant acute vascular physiological effects, and these observations suggest certain nanoparticles infusions may beassociated with acute vascular physiologic effects that merit further attention. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2012 journal article

Experimental factors affecting in vitro absorption of six model compounds across porcine skin

Toxicology in Vitro, 26(7), 1191–1198.

By: D. Karadzovska, J. Brooks* & J. Riviere*

author keywords: Dermal absorption/penetration; Diffusion cells; Saturated; Unsaturated; Finite; Infinite; Albumin
MeSH headings : Administration, Cutaneous; Animals; Cattle; Diffusion; Female; In Vitro Techniques; Models, Biological; Permeability / drug effects; Serum Albumin, Bovine / metabolism; Skin / drug effects; Skin / metabolism; Skin Absorption; Swine; Xenobiotics / administration & dosage; Xenobiotics / pharmacokinetics
TL;DR: The overall results emphasize the importance of experimental design and confirm previous findings that identified dose volume, saturation level and vehicle as the main sources of variation in the in vitro assessment of dermal absorption, whilst diffusion cell model and the presence/absence of BSA in the receptor phase had minimal effect. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2012 journal article

In vitro biodistribution of silver nanoparticles in isolated perfused porcine skin flaps

JOURNAL OF APPLIED TOXICOLOGY, 32(11), 913–919.

By: T. Leavens n , N. Monteiro-Riviere n , A. Inman n, J. Brooks n, S. Oldenburg* & J. Riviere n

Contributors: T. Leavens n , N. Monteiro-Riviere n , A. Inman n, J. Brooks n, S. Oldenburg* & J. Riviere n

author keywords: silver nanoparticles; biodistribution; skin
MeSH headings : Animals; Metal Nanoparticles / chemistry; Nanoparticles / chemistry; Perfusion; Silver / chemistry; Silver / pharmacokinetics; Skin / metabolism; Swine / metabolism; Tissue Distribution
TL;DR: The objective of the present study was to quantify the local biodistribution of two types of Ag nanoparticles, Ag‐citrate and Ag‐silica, in the isolated perfused porcine skin flap (IPPSF), and found no detectable elimination of Ag from the system. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2011 journal article

Predicting Skin Permeability from Complex Chemical Mixtures: Dependency of Quantitative Structure Permeation Relationships on Biology of Skin Model Used

TOXICOLOGICAL SCIENCES, 119(1), 224–232.

By: J. Riviere n & J. Brooks n

author keywords: chemical mixtures; percutaneous; dermal absorption; quantitative structure-activity relationships (QSAR); QSPR; skin permeability; in vitro models; pesticide risk assessment
MeSH headings : Animals; Complex Mixtures / chemistry; Complex Mixtures / pharmacokinetics; Environmental Pollutants / chemistry; Environmental Pollutants / pharmacokinetics; In Vitro Techniques; Models, Biological; Permeability; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Skin / metabolism; Skin Absorption; Sus scrofa
TL;DR: The findings suggest that a QSPR model for estimating percutaneous absorption as a function of chemical mixture composition is possible and that the nature of the Q SPR model selected is dependent upon the biological level of the in vitro test system used, both findings having significant implications when dermal absorption data are used for in vivo risk assessments. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Modelling the effect of mixture components on permeation through skin

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 398(1-2), 28–32.

By: T. Ghafourian *, E. Samaras*, J. Brooks n & J. Riviere n

author keywords: Skin; QSAR; Formulation; Mixture; Permeation; Penetration
MeSH headings : Administration, Cutaneous; Animals; Permeability / drug effects; Pharmaceutical Preparations / administration & dosage; Pharmaceutical Preparations / metabolism; Quantitative Structure-Activity Relationship; Skin Absorption / drug effects; Skin Absorption / physiology; Swine
TL;DR: The findings show that compounds formulated in vehicles with small boiling and melting point gaps will be expected to have higher permeation through skin, compared with compounds in the common skin permeability datasets used in QSAR. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2010 dataset

Riviere and Brooks pig skin flow-through [data file]

By: J. Riviere & J. Brooks

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Surfactant Effects on Skin Absorption of Model Organic Chemicals: Implications for Dermal Risk Assessment Studies

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, 73(11), 725–737.

By: J. Riviere n, J. Brooks n, J. Yeatts n & E. Koivisto n

MeSH headings : Administration, Cutaneous; Alkanesulfonic Acids / pharmacology; Animals; Complex Mixtures / chemistry; Complex Mixtures / pharmacokinetics; Drug Interactions; Female; Membranes, Artificial; Organic Chemicals / pharmacokinetics; Risk Assessment; Skin / drug effects; Skin / metabolism; Skin Absorption / drug effects; Skin Absorption / physiology; Sodium Dodecyl Sulfate / pharmacology; Solubility; Surface-Active Agents / pharmacology; Surgical Flaps; Swine; Water / chemistry
TL;DR: The inert three-fiber MCF array predicted absorptive fluxes seen in the ex vivo IPPSF, suggesting lack of any biological effects of the surfactants on skin. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Validated models for predicting skin penetration from different vehicles

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 41(5), 612–616.

By: T. Ghafourian *, E. Samaras*, J. Brooks n & J. Riviere n

author keywords: Skin; Penetration; QSAR; Permeation; Formulation; Mixture
MeSH headings : Administration, Cutaneous; Animals; Caffeine / chemistry; Codeine / chemistry; Complex Mixtures / chemistry; Complex Mixtures / pharmacokinetics; Models, Chemical; Models, Statistical; Molecular Structure; Octanols / chemistry; Permeability; Pharmaceutical Vehicles / chemistry; Quantitative Structure-Activity Relationship; Skin / metabolism; Skin Absorption / physiology; Swine; Testosterone / chemistry
TL;DR: The aim of this Quantitative Structure Activity Relationship (QSAR) study was to develop a statistically validated model for the prediction of skin permeability coefficients of compounds dissolved in different vehicles and to help with the elucidation of the mechanisms involved in the permeation process. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Determination of the effective dermal penetration barrier pH of porcine skin

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 32(4), 407–410.

By: J. Riviere n & J. Brooks n

MeSH headings : Animals; Hydrogen-Ion Concentration; Linear Models; Models, Biological; Nitrophenols / pharmacokinetics; Organophosphates / pharmacokinetics; Pentachlorophenol / pharmacokinetics; Skin / chemistry; Skin / metabolism; Skin Absorption / physiology; Swine; Triazines / pharmacokinetics
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2007 article

Prediction of dermal absorption from complex chemical mixtures: incorporation of vehicle effects and interactions into a QSPR framework

SAR AND QSAR IN ENVIRONMENTAL RESEARCH, Vol. 18, pp. 31–44.

By: J. Riviere n & J. Brooks n

author keywords: dermal absorption; chemical mixtures; QSAR; LFER
MeSH headings : Administration, Topical; Animals; Complex Mixtures / administration & dosage; Complex Mixtures / chemistry; Complex Mixtures / pharmacokinetics; Dermis / metabolism; In Vitro Techniques; Models, Biological; Models, Chemical; Permeability; Pharmaceutical Vehicles / chemistry; Pharmaceutical Vehicles / pharmacokinetics; Quantitative Structure-Activity Relationship; Skin Absorption; Swine / metabolism; Toxicology / methods
TL;DR: This work has explored using hybrid QSPR equations describing individual compound penetration based on the molecular descriptors for the compound modified by a mixture factor which accounts for the physicochemical properties of the vehicle/mixture components. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2006 journal article

A physiologically based pharmacokinetic model of organophosphate dermal absorption

TOXICOLOGICAL SCIENCES, 89(1), 188–204.

By: D. Merwe  n, J. Brooks n, R. Gehring n, R. Baynes n, N. Monteiro-Riviere n  & J. Riviere n

Contributors: D. Merwe  n, J. Brooks n, R. Gehring n, R. Baynes n, N. Monteiro-Riviere n  & J. Riviere n

author keywords: dermal absorption; PBPK model; parathion; fenthion; methyl parathion
MeSH headings : Administration, Cutaneous; Animals; Dose-Response Relationship, Drug; Fenthion / pharmacokinetics; In Vitro Techniques; Insecticides / pharmacokinetics; Methyl Parathion / pharmacokinetics; Models, Biological; Organothiophosphorus Compounds / pharmacokinetics; Parathion / pharmacokinetics; Risk Assessment; Skin / metabolism; Skin Absorption / physiology; Skin Physiological Phenomena; Solubility; Swine
TL;DR: The similarity between the overall shapes of the experimental and model-predicted flux/time curves and the successful simulation of altered system conditions for this series of small, lipophilic compounds indicated that the absorption processes were successfully simulated important aspects of dermal absorption in flow-through cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2005 journal article

Pre-treatment effects of trichloroethylene on the dermal absorption of the biocide, triazine

TOXICOLOGY LETTERS, 159(3), 252–260.

By: R. Baynes n, J. Yeatts n, J. Brooks n & J. Riviere n

author keywords: triazine; skin; TCE; cutting fluids
MeSH headings : Animals; Diffusion Chambers, Culture; Female; In Vitro Techniques; Metallurgy; Permeability; Skin / drug effects; Skin / metabolism; Skin Absorption / drug effects; Swine; Triazines / pharmacokinetics; Trichloroethylene / pharmacology
TL;DR: It is demonstrated that TCE pre-treatment can significantly alter the dermal permeability to triazine, and workers who are chronically exposed to this or similar cleansers may be at increased risk of absorbing related skin irritants. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Predicting skin permeability from complex chemical mixtures

TOXICOLOGY AND APPLIED PHARMACOLOGY, 208(2), 99–110.

By: J. Riviere n & J. Brooks n

author keywords: QSPeR; QSAR; dermal absorption; risk assessment; chemical mixtures
MeSH headings : Algorithms; Animals; Chemical Phenomena; Chemistry, Physical; Complex Mixtures / chemistry; Complex Mixtures / pharmacokinetics; Complex Mixtures / toxicity; Diffusion Chambers, Culture; Hydrogen / chemistry; In Vitro Techniques; Linear Models; Models, Statistical; Pharmaceutical Preparations / metabolism; Pharmaceutical Vehicles; Quantitative Structure-Activity Relationship; Refractometry; Risk Assessment; Skin Absorption / physiology; Swine
TL;DR: The importance of these findings is that there is an approach whereby the effects of a mixture on dermal absorption of a penetrant of interest can be quantitated in a standard QSPeR model if physicochemical properties of the mixture are also incorporated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Comparative mixture effects of JP-8(100) additives on the dermal absorption and disposition of jet fuel hydrocarbons in different membrane model systems

TOXICOLOGY LETTERS, 150(3), 351–365.

By: F. Muhammad n, J. Brooks n & J. Riviere n

author keywords: JP-8(100); mixture effects; comparative absorption; membrane models
MeSH headings : Administration, Topical; Alkanes / pharmacokinetics; Animals; Carbon Radioisotopes; Cell Membrane Permeability / drug effects; Dimethylpolysiloxanes / chemistry; Hydrocarbons / pharmacokinetics; In Vitro Techniques; Membranes, Artificial; Models, Biological; Naphthalenes / pharmacokinetics; Silicones / chemistry; Skin / drug effects; Skin / metabolism; Skin Absorption / drug effects; Swine
TL;DR: The observations demonstrate that the single membrane system may not be suitable for the final prediction of complex additive interactions in jet fuels and rather a combination of different membrane systems may provide the insight to elucidate the possible mechanism for additive interactions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2003 journal article

In vitro percutaneous absorption of nonylphenol (NP) and nonylphenol ethoxylates (NPE-4 and NPE-9) in isolated perfused skin

JOURNAL OF TOXICOLOGY-CUTANEOUS AND OCULAR TOXICOLOGY, 22(1-2), 1–11.

By: N. Monteiro-Riviere n , J. Van Miller, G. Simon, R. Joiner*, J. Brooks n & J. Riviere n

Contributors: N. Monteiro-Riviere n , J. Van Miller, G. Simon, R. Joiner*, J. Brooks n & J. Riviere n

TL;DR: The penetration of NPEs and NP in the IPPSF was less than the PSFT and is probably more predictive of in vivo human absorption as this model is physiologically closer to human skin. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2003 journal article

Percutaneous absorption of 2,6-di-tert-butyl-4-nitrophenol (DBNP) in isolated perfused porcine skin

TOXICOLOGY IN VITRO, 17(3), 289–292.

By: A. Inman n, K. Still*, W. Jederberg*, R. Carpenter*, J. Riviere n, J. Brooks n, N. Monteiro-Riviere n 

Contributors: A. Inman n, K. Still*, W. Jederberg*, R. Carpenter*, J. Riviere n, J. Brooks n, N. Monteiro-Riviere n 

author keywords: 2,6-di-tert-butyl-4-nitrophenol; skin absorption; porcine skin; dermal exposure
MeSH headings : Absorption; Administration, Cutaneous; Air Pollution, Indoor; Animals; Antioxidants; Humans; Military Personnel; Nitrophenols / pharmacokinetics; Phenols / chemistry; Skin Physiological Phenomena; Static Electricity; Submarine Medicine; Swine
TL;DR: DBNP absorption was minimal across all treatment groups, with the highest absorption detected being only 1.08% applied dose in an aqueous ethanol group, suggesting that there is minimal dermal exposure of DBNP when exposed topically to skin. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2003 journal article

Percutaneous absorption of topical N,N-diethyl-m-toluamide (DEET): Effects of exposure variables and coadministered toxicants

Journal of Toxicology and Environmental Health. Part A, 66(2), 133–151.

By: J. Riviere, R. Baynes, J. Brooks, J. Yeatts & N. Monteiro-Riviere 

Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2002 journal article

Effect of chemical interactions in pentachlorophenol mixtures on skin and membrane transport

TOXICOLOGICAL SCIENCES, 69(2), 295–305.

By: R. Baynes*, J. Brooks, M. Mumtaz & J. Riviere

author keywords: pentachorophenol; mixtures; interactions; skin; absorption; surfactants; vehicle
MeSH headings : Animals; Chemical Phenomena; Chemistry, Physical; Diffusion; Ethanol / pharmacology; In Vitro Techniques; Insecticides / chemistry; Insecticides / pharmacokinetics; Insecticides / toxicity; Membranes / metabolism; Nicotinic Acids / pharmacology; Pentachlorophenol / chemistry; Pentachlorophenol / pharmacokinetics; Pentachlorophenol / toxicity; Permeability / drug effects; Pharmaceutical Vehicles; Skin Absorption / drug effects; Sodium Dodecyl Sulfate / pharmacology; Solvents / pharmacology; Viscosity
TL;DR: It is demonstrated that modification in mixture composition with either a solvent and/or a surfactant can influence PCP diffusion in skin. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Physicochemical determinants of linear alkylbenzene sulfonate (LAS) disposition in skin exposed to aqueous cutting fluid mixtures

TOXICOLOGY AND INDUSTRIAL HEALTH, 18(5), 237–248.

By: R. Baynes n, J. Brooks n, B. Barlow n & J. Riviere n

author keywords: cutting fluids; LAS; mixtures; physicochemical interactions; skin
MeSH headings : Alkanesulfonic Acids / chemistry; Alkanesulfonic Acids / pharmacokinetics; Alkanesulfonic Acids / toxicity; Animals; Dermatitis, Contact / etiology; Metallurgy; Mineral Oil / pharmacology; Occupational Exposure; Permeability; Polyethylene Glycols / pharmacology; Skin Absorption / drug effects; Solubility; Solvents / pharmacology; Surface-Active Agents / chemistry; Surface-Active Agents / pharmacokinetics; Surface-Active Agents / toxicity; Swine
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Mixture component effects on the in vitro dermal absorption of pentachlorophenol

Archives of Toxicology, 75(6), 329–334.

By: J. Riviere n, G. Qiao n, R. Baynes n, J. Brooks n & M. Mumtaz *

MeSH headings : Administration, Topical; Animals; Culture Techniques; Dermis / blood supply; Dermis / metabolism; Dose-Response Relationship, Drug; Environmental Pollutants / administration & dosage; Environmental Pollutants / pharmacokinetics; Ethanol / pharmacology; Irritants / pharmacology; Nicotinic Acids / pharmacology; Pentachlorophenol / administration & dosage; Pentachlorophenol / pharmacokinetics; Perfusion; Polychlorinated Biphenyls / administration & dosage; Polychlorinated Biphenyls / pharmacokinetics; Risk Assessment; Skin Absorption; Sodium Dodecyl Sulfate / pharmacology; Surface-Active Agents / pharmacology; Swine
TL;DR: The results suggest that dermal absorption estimates from a single chemical exposure may not reflect absorption seen after exposure as a chemical mixture and that absorption of both TCB and PCB are minimal in this model system. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

Mixture effects of JP-8 additives on the dermal disposition of jet fuel components

TOXICOLOGY AND APPLIED PHARMACOLOGY, 175(3), 269–281.

By: R. Baynes n, J. Brooks n, K. Budsaba n, C. Smith n & J. Riviere n

author keywords: jet fuels; mixtures; skin; interactions; absorption
MeSH headings : Alkanes / pharmacokinetics; Animals; Drug Synergism; Hydrocarbons / chemistry; Hydrocarbons / pharmacokinetics; In Vitro Techniques; Kerosene; Naphthalenes / pharmacokinetics; Perfusion; Skin / drug effects; Skin / metabolism; Skin Absorption; Swine; Tissue Distribution
TL;DR: The data suggest that various combinations of these three performance additives in JP-8 can potentially alter the dermal disposition of aromatic and aliphatic fuel components in skin. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Use of methyl salicylate as a simulant to predict the percutaneous absorption of sulfur mustard

JOURNAL OF APPLIED TOXICOLOGY, 21(2), 91–99.

By: J. Riviere n, C. Smith n, K. Budsaba n, J. Brooks n, E. Olajos*, H. Salem*, N. Monteiro-Riviere n 

Contributors: J. Riviere n, C. Smith n, K. Budsaba n, J. Brooks n, E. Olajos*, H. Salem*, N. Monteiro-Riviere n 

MeSH headings : Administration, Cutaneous; Adsorption; Animals; Area Under Curve; Carbon Radioisotopes; Culture Techniques; Dermatologic Agents / pharmacokinetics; Fixatives; Models, Biological; Mustard Gas / pharmacokinetics; Salicylates / pharmacokinetics; Skin / drug effects; Skin / pathology; Swine
TL;DR: Compared with other chemicals studied in this model, HD and MS cutaneous disposition were very similar, supporting the use of MS as a dermal simulant for HD exposure. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2000 journal article

Comparative in vitro percutaneous absorption of nonylphenol and nonylphenol ethoxylates (NPE-4 and NPE-9) through human, porcine and rat skin

Toxicology and Industrial Health, 16(2), 49–57.

By: N. Monteiro-Riviere* , J. Miller, G. Simon, R. Joiner, J. Brooks* & J. Riviere*

UN Sustainable Development Goal Categories
Sources: NC State University Libraries, NC State University Libraries, ORCID
Added: August 6, 2018

2000 journal article

Dermatotoxicokinetic modeling of p-nitrophenol and its conjugation metabolite in swine following topical and intravenous administration

TOXICOLOGICAL SCIENCES, 54(2), 284–294.

By: G. Qiao*, S. Chang, J. Brooks* & J. Riviere*

author keywords: p-nitrophenol (PNP); toxicokinetics; skin absorption; metabolism; pig
MeSH headings : Administration, Topical; Animals; Area Under Curve; Drug Administration Routes; Female; Injections, Intravenous; Models, Biological; Nitrophenols / administration & dosage; Nitrophenols / pharmacokinetics; Skin / metabolism; Swine; Tissue Distribution
TL;DR: It was suggested by experimental observation and modeling that urinary 14 C excretion correlates with the systemic tissue depletion profile well and may be used as a biomarker of PNP exposure and supports the strategy of using urinary PNP as a biomonitoring tool for OP pesticide exposure. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Membrane transport of naphthalene and dodecane in jet fuel mixtures

Toxicology and Industrial Health, 16(6), 225–238.

By: R. Baynes*, J. Brooks* & J. Riviere*

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Methods of assessing the percutaneous absorption of volatile chemicals in isolated perfused skin: Studies with chloropentafluorobenzene and dichlorobenzene

TOXICOLOGY METHODS, 10(4), 265–281.

By: J. Riviere n, J. Brooks n & G. Qiao*

author keywords: chloropentafluorobenzene; dermal absorption; dichlorobenzene; volatile chemicals
TL;DR: It was found that the effects of solvents on compound absorption that are routinely described in liquid dosing scenarios were also detected when both the compound and solvent were exposed during the vapor phase. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Dermal Absorption and Distribution of Topically Dosed Jet Fuels Jet-A, JP-8, and JP-8(100)

Toxicology and Applied Pharmacology, 160(1), 60–75.

By: J. Riviere n, J. Brooks n, N. Monteiro-Riviere n , K. Budsaba n & C. Smith n

Contributors: J. Riviere n, J. Brooks n, N. Monteiro-Riviere n , K. Budsaba n & C. Smith n

author keywords: jet fuel; naphthalene; dodecane; hexadecane; percutaneous/dermal absorption; skin
MeSH headings : Administration, Topical; Aircraft; Alkanes / pharmacokinetics; Animals; Fuel Oils; Naphthalenes / pharmacokinetics; Perfusion; Skin / metabolism; Skin Absorption; Swine
TL;DR: Different absorption profiles for the three marker compounds, differential effects of jet fuel types on naphthalene and dodecane absorption, and uncoupling of perfusate absorption from skin disposition are demonstrated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

1997 journal article

Pentachlorophenol dermal absorption and disposition from soil in swine: Effects of occlusion and skin microorganism inhibition

TOXICOLOGY AND APPLIED PHARMACOLOGY, 147(2), 234–246.

By: G. Qiao n, J. Brooks n & J. Riviere n

MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Carbon Radioisotopes; Female; Pentachlorophenol / metabolism; Pesticides / metabolism; Skin / drug effects; Skin / metabolism; Skin / microbiology; Skin Absorption; Soil; Soil Pollutants / metabolism; Swine
TL;DR: Significant dermal absorption and extensive tissue persistence of PCP after soil exposure is demonstrated and exposure-specific PCP absorption and disposition profiles must be taken into consideration in risk analysis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1997 report

Percutaneous absorption of volatile chemicals

In (NTIS report AFOSR G49620-95-1-0017) (pp. 1–23).

By: J. Riviere*, J. Brooks*, G. Qiao* & N. Monteiro-Riviere* 

TL;DR: These studies demonstrated dose-dependent absorption of CPFB and DCB in skin which was further modulated by concomitant exposure to vehicle, and could be used as direct input into a systemic risk assessment model. (via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

1996 journal article

Cutaneous metabolism of isosorbide dinitrate after transdermal administration in isolated perfused porcine skin

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 127(2), 213–217.

By: J. Riviere n, J. Brooks n, P. Williams  n, E. McGown* & M. Francoeur*

author keywords: isosorbide dinitrate; isosorbide mononitrate; cutaneous metabolism; IPPSF; skin flap; percutaneous delivery device
TL;DR: Observations indicate that a fraction of ISDN is biotransformed during transdermal delivery, and this in vitro model possesses a viable epidermis and intact vasculature, two attributes ideal for studying theBiotransformation of a vasoactive drug. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1996 journal article

Quantitative percutaneous absorption and cutaneous distribution of binary mixtures of phenol and para-nitrophenol in isolated perfused porcine skin

FUNDAMENTAL AND APPLIED TOXICOLOGY, 32(2), 233–243.

By: J. Brooks n & J. Riviere

MeSH headings : Animals; In Vitro Techniques; Nitrophenols / pharmacokinetics; Phenol; Phenols / pharmacokinetics; Skin / metabolism; Skin Absorption; Swine; Tissue Distribution
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1996 journal article

The use of mechanistically defined chemical mixtures (MDCM) to assess component effects on the percutaneous absorption and cutaneous disposition of topically exposed chemicals .1. Studies with parathion mixtures in isolated perfused porcine skin

TOXICOLOGY AND APPLIED PHARMACOLOGY, 141(2), 473–486.

By: G. Qiao n, J. Brooks n, R. Baynes n, N. MonteiroRiviere  n, P. Williams  n & J. Riviere n

Contributors: G. Qiao n, J. Brooks n, R. Baynes n, N. MonteiroRiviere  n, P. Williams  n & J. Riviere n

MeSH headings : Animals; Dimethyl Sulfoxide / pharmacology; Female; Insecticides / pharmacokinetics; Parathion / pharmacokinetics; Perfusion; Risk Assessment; Skin / blood supply; Skin / metabolism; Skin Absorption; Surface-Active Agents / pharmacology; Swine
TL;DR: This study indicated multiple levels of interactive effects on PA absorption which must be incorporated into any effort to identify critical mechanisms which affect risk assessment of topically exposed mixtures. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

1995 journal article

ENHANCING OR BLOCKING EFFECT OF FENVALERATE ON THE SUBSEQUENT PERCUTANEOUS-ABSORPTION OF PESTICIDES IN-VITRO

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 51(3), 214–219.

By: S. Chang n, J. Brooks n, N. Monteiroriviere  n & J. Riviere n

TL;DR: The total absorption of these pesticides, both ethanol control and fenvalerate or parathion pretreated, increased proportionally with the dose; however, the absorption efficiency (fraction of applied dose absorbed) decreased as the dose increased. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1995 journal article

TOXICOKINETICS OF TOPICAL SULFUR MUSTARD PENETRATION, DISPOSITION, AND VASCULAR TOXICITY IN ISOLATED-PERFUSED PORCINE SKIN

TOXICOLOGY AND APPLIED PHARMACOLOGY, 135(1), 25–34.

By: J. Riviere n, J. Brooks n, P. Williams  n & N. Monteiroriviere n

Contributors: J. Riviere n, J. Brooks n, P. Williams  n & N. Monteiroriviere n

MeSH headings : Animals; Blood Volume / drug effects; Dermatologic Agents / pharmacokinetics; Dermatologic Agents / toxicity; In Vitro Techniques; Models, Biological; Mustard Gas / pharmacokinetics; Mustard Gas / toxicity; Perfusion; Skin / blood supply; Skin / drug effects; Skin Absorption / drug effects; Swine
TL;DR: A toxicokinetic model is formulated that provides a quantitative profile of the time course of HD disposition within skin which would aid in the interpretation of mechanistic studies of vesication as well as in designing interventive antivesicant drug strategies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

1994 journal article

Determination of physicochemical properties of phenol, p-nitrophenol, acetone and ethanol relevant to quantitating their percutaneous absorption in porcine skin

Research Communications in Chemical Pathology and Pharmacology, 83, 61–75.

By: P. William, J. Brooks, A. Inman, N. Monteiro-Riviere  & J. Riviere

Source: NC State University Libraries
Added: August 6, 2018

1994 report

Mechanisms of cutaneous vesication

In DAMD17-92-C-2071; NTIS, ADA283085 (Vol. 114, pp. 1–114). DAMD 17-92-C-2071, NTIS Report, ADA 283085.

By: N. Monteiro-Riviere , J. Zhang, A. Inman, J. Brooks & J. Riviere

Source: NC State University Libraries
Added: August 6, 2018

1992 conference paper

Effect of vehicle and application site on absorption of chemicals through equine skin

Proceedings, 38th Annual Convention of the American Association of Equine Practitioners, 38, 725.

By: D. Bristol, J. Riviere, N. Monteiro-Riviere , J. Brooks & R. Rogers

Source: NC State University Libraries
Added: August 6, 2018

journal article

NDELA and nickel modulation of triazine disposition in skin

Baynes, R. E., Brooks, J. D., Barlow, B. M., & Riviere, J. E. Toxicology and Industrial Health, 21(9), 197–205.

By: R. Baynes, J. Brooks, B. Barlow & J. Riviere

Source: NC State University Libraries
Added: August 6, 2018

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