2023 article

Exploiting Microelectrode Geometry for Comprehensive Detection of Individual Exocytosis Events at Single Cells

De Alwis, A. C., Denison, J. D., Shah, R., McCarty, G. S., & Sombers, L. A. (2023, August 8). ACS SENSORS, Vol. 8.

By: A. De Alwis n, J. Denison n, R. Shah n, G. McCarty n & L. Sombers n

author keywords: voltammetry; amperometry; chromaffincell; diffusion; catecholamine; dense corevesicle; carbon fiber microelectrode
TL;DR: This work demonstrates how electrode geometry can be exploited for improved detection of exocytosis events by addressing diffusional loss─an often-overlooked source of inaccuracy in single-cell measurements. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 21, 2023

2023 journal article

Untapped Potential: Real-Time Measurements of Opioid Exocytosis at Single Cells

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 145(44), 24071–24080.

By: J. Denison n, A. De Alwis n, R. Shah n, G. Mccarty n & L. Sombers n

TL;DR: Comparing the results collected at the two potentials reveals unique kinetics for these two neurochemical classes at the single-vesicle level, providing unprecedented insight into key differences between catecholamine and opioid neuropeptide release from isolated chromaffin cells. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: December 11, 2023

2022 article

Neurotransmitter Readily Escapes Detection at the Opposing Microelectrode Surface in Typical Amperometric Measurements of Exocytosis at Single Cells

McCarty, G. S., Dunaway, L. E., Denison, J. D., & Sombers, L. A. (2022, June 24). ANALYTICAL CHEMISTRY, Vol. 6.

By: G. McCarty n, L. Dunaway n, J. Denison n & L. Sombers n

MeSH headings : Animals; Carbon Fiber; Catecholamines / metabolism; Cattle; Chromaffin Cells / metabolism; Exocytosis / physiology; Microelectrodes; Neurotransmitter Agents / metabolism
TL;DR: This study characterizes distinct physical and biological mechanisms by which released neurotransmitter escapes detection at the opposing microelectrode surface, while also revealing an important role for the NET in “presynaptic” modulation of neurotransmitter release. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: July 18, 2022

2020 journal article

Interpreting Dynamic Interfacial Changes at Carbon Fiber Microelectrodes Using Electrochemical Impedance Spectroscopy

Langmuir, 36(15), 4214–4223.

By: C. Meunier n, J. Denison n, G. McCarty n & L. Sombers n

MeSH headings : Carbon; Carbon Fiber; Dielectric Spectroscopy; Electric Impedance; Microelectrodes
TL;DR: Electrochemical impedance spectroscopy is established as a powerful method for characterization of carbon-fiber microelectrodes, providing unprecedented insight into how real-world factors affect the electrode/solution interface. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: May 8, 2020

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