Works (3)

Updated: July 5th, 2023 15:56

2019 journal article

IL22 Inhibits Epithelial Stem Cell Expansion in an Ileal Organoid Model


By: B. Zwarycz*, A. Gracz*, K. Rivera n, I. Williamson n, L. Samsa*, J. Starmer*, M. Daniele n, L. Salter-Cid*, Q. Zhao*, S. Magness n

author keywords: Intestinal Stem Cells; Interleukin-22; Inflammatory Bowel Disease
MeSH headings : Animals; Biomarkers / metabolism; Cell Lineage / drug effects; Cell Proliferation / drug effects; Cell Self Renewal / drug effects; Cellular Microenvironment / drug effects; Computer Simulation; Epithelial Cells / cytology; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Ileum / cytology; Inflammatory Bowel Diseases / pathology; Interleukins / pharmacology; Mice, Inbred C57BL; Models, Biological; Organoids / cytology; Organoids / drug effects; Organoids / metabolism; Receptors, Interleukin / metabolism; Serum / metabolism; Stem Cells / cytology; Stem Cells / drug effects; Stem Cells / metabolism
TL;DR: Increased IL22 limits ISC expansion in favor of increased TA progenitor cell expansion, and chronically increased IL22 levels, similar to predicted microenvironment levels, showed increases in proliferative cells in the TA zone with no increase in ISCs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: January 14, 2019

2009 journal article

Sequence analysis of rice rubi3 promoter gene expression cassettes for improved transgene expression

PLANT SCIENCE, 177(6), 549–556.

By: E. Sivamani n, J. Starmer* & R. Qu n

author keywords: Exon; GUS; IME; rRNA; rubi3 promoter; Translation
TL;DR: Sequence analysis suggests that complementarity between sequences immediately 5′ of a translation initiation codon and the rice 17S rRNA may be responsible for the reduction in protein levels from constructs containing the GUS leader sequence. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Predicting Shine-Dalgarno sequence locations exposes genome annotation errors


By: J. Starmer n, A. Stomp n, M. Vouk n & D. Bitzer n

MeSH headings : Base Sequence; Codon, Initiator / genetics; Computational Biology; Escherichia coli / genetics; Gene Expression Regulation, Bacterial / genetics; Genome, Bacterial / genetics; Hydrogen Bonding; Models, Genetic; Peptide Chain Initiation, Translational / genetics; RNA, Messenger / genetics; RNA, Messenger / metabolism; RNA, Ribosomal / genetics; RNA, Ribosomal / metabolism; Research Design
TL;DR: A new metric, relative spacing (RS), is created to identify both the location and the hybridization potential of SD sequences by simulating the binding between mRNAs and single-stranded 16S rRNA 3′ tails and provides a new way to explore the role of rRNA–mRNA nucleotide hybridization in translation initiation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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