Jenessa A. Winston

Works (8)

Updated: July 27th, 2023 21:18

2021 journal article

Secondary bile acid ursodeoxycholic acid alters weight, the gut microbiota, and the bile acid pool in conventional mice

PLOS ONE, 16(2).

By: J. Winston n, A. Rivera n, J. Cai *, A. Patterson * & C. Theriot n

MeSH headings : Animals; Body Weight / drug effects; Cecum / microbiology; Feces / microbiology; Female; Gastrointestinal Microbiome / drug effects; Ileum / microbiology; Male; Metabolome / drug effects; Mice, Inbred C57BL; Receptors, Cytoplasmic and Nuclear / metabolism; Receptors, G-Protein-Coupled / metabolism; Ursodeoxycholic Acid / administration & dosage; Ursodeoxycholic Acid / pharmacology; Weight Loss / drug effects
TL;DR: This study is the first to provide a comprehensive view of how exogenously administered ursodiol shapes the healthy gastrointestinal ecosystem in conventional mice and how these changes in turn modify the host physiologic response are important. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: March 22, 2021

2020 journal article

Clostridioides difficile carriage in animals and the associated changes in the host fecal microbiota

ANAEROBE, 66.

By: R. Thanissery n, M. McLaren n , A. Rivera n, A. Reed n, N. Betrapally n, T. Burdette n, J. Winston n, M. Jacob n, B. Callahan n , C. Theriot n

author keywords: C. difficile; C. hiranonis; Microbiome; Ribotype; Antibiotic resistance; Animal; Canine; Equine; Feline
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Bacterial Toxins / genetics; Bacterial Toxins / metabolism; Bacterial Typing Techniques; Cats; Chlorocebus aethiops; Clostridioides difficile / classification; Clostridioides difficile / drug effects; Clostridioides difficile / physiology; Clostridium Infections / epidemiology; Clostridium Infections / microbiology; Clostridium Infections / veterinary; Coculture Techniques; Dogs; Feces / microbiology; Female; Gastrointestinal Microbiome; Horses; Hospitals, Animal; Host-Pathogen Interactions; Male; Microbial Interactions; Microbial Sensitivity Tests; North Carolina; Polymerase Chain Reaction; Prevalence; RNA, Ribosomal, 16S; Ribotyping; Risk Factors; Tertiary Healthcare; Vero Cells
TL;DR: Experimental results showed a clear antagonistic relationship between the two strains in vitro, suggesting that commensal Clostridia might play a role in colonization resistance against C. difficile in different hosts. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: January 11, 2021

2020 review

Diversification of host bile acids by members of the gut microbiota

[Review of ]. GUT MICROBES, 11(2), 158–171.

By: J. Winston n & C. Theriot n

author keywords: C. difficile; bile acids; gut microbiota; ursodeoxycholic acid (UDCA); FXR
MeSH headings : Animals; Bacteria / metabolism; Bile Acids and Salts / biosynthesis; Bile Acids and Salts / metabolism; Cholesterol / metabolism; Clostridioides difficile / pathogenicity; Gastrointestinal Microbiome / drug effects; Gastrointestinal Microbiome / physiology; Hepatocytes / metabolism; Humans; Lipid Metabolism; Microbiota / drug effects; Receptors, Cytoplasmic and Nuclear / metabolism; Ursodeoxycholic Acid / pharmacology
TL;DR: The physiologic aspects of collaborative bile acid metabolism by the host and gut microbiota are described and the effects of ursodeoxycholic acid (UDCA) administration, a common therapeutic bile acids administration, on the gut microbiota-bile acid-host axis are discussed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: March 30, 2020

2020 journal article

Ursodeoxycholic Acid (UDCA) Mitigates the Host Inflammatory Response during Clostridioides difficile Infection by Altering Gut Bile Acids

INFECTION AND IMMUNITY, 88(6).

By: J. Winston n, A. Rivera n, J. Cai *, R. Thanissery n, S. Montgomery*, A. Patterson *, C. Theriot n

author keywords: C. difficile; FXR; UDCA; bile acids; inflammation; microbiome; ursodiol
MeSH headings : Animals; Bile Acids and Salts / metabolism; Biomarkers; Clostridioides difficile / drug effects; Clostridium Infections / drug therapy; Clostridium Infections / genetics; Clostridium Infections / metabolism; Clostridium Infections / microbiology; Computational Biology / methods; Dose-Response Relationship, Drug; Fibroblast Growth Factors / metabolism; Fragile X Mental Retardation Protein / metabolism; Gastrointestinal Microbiome / drug effects; Gene Expression Profiling; Host-Pathogen Interactions / drug effects; Host-Pathogen Interactions / genetics; Humans; Life Cycle Stages; Mice; Signal Transduction; Transcriptome; Ursodeoxycholic Acid / pharmacology; Ursodeoxycholic Acid / physiology
TL;DR: Although ursodiol pretreatment did not result in a consistent decrease in the C. difficile life cycle in vivo, it was able to attenuate an overly robust inflammatory response that is detrimental to the host during CDI. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: June 15, 2020

2017 article

Inhibition of spore germination, growth, and toxin activity of clinically relevant C-difficile strains by gut microbiota derived secondary bile acids

Thanissery, R., Winston, J. A., & Theriot, C. M. (2017, June). ANAEROBE, Vol. 45, pp. 86–100.

By: R. Thanissery n, J. Winston n & C. Theriot n

author keywords: C. difficile; Bile acids; Gut microbiota; Metabolome; Germination; Growth; Toxin
MeSH headings : Animals; Anti-Bacterial Agents / metabolism; Antibiosis; Bacterial Toxins / metabolism; Bile Acids and Salts / metabolism; Clostridioides difficile / drug effects; Clostridioides difficile / growth & development; Gastrointestinal Microbiome; Gastrointestinal Tract / microbiology; Humans; Mice; Spores, Bacterial / drug effects; Spores, Bacterial / growth & development
TL;DR: It is shown how clinically relevant C. difficile strains can have different responses when exposed to SBAs present in the gastrointestinal tract, and how these responses vary across all strains and ribotypes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, (118).

By: J. Winston n, R. Thanissery n, S. Montgomery & C. Theriot n

author keywords: Infection; Issue 118; Clostridium difficile; mouse model; antibiotic; colonization; cytotoxicity; histology; inflammation; Vero cells
MeSH headings : Animals; Anti-Bacterial Agents; Cefoperazone / pharmacology; Clostridioides difficile / drug effects; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL
TL;DR: This cefoperazone mouse model of CDI proves a valuable experimental platform to assess the effects of novel therapeutics on the amelioration of clinical disease and on the restoration of colonization resistance against C. difficile. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Cyniclomyces guttulatus Infection in Dogs: 19 Cases (2006-2013)

JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION, 52(1), 42–51.

By: J. Winston n, I. Piperisova n, J. Neel n  & J. Gookin n 

Contributors: J. Winston n, I. Piperisova n, J. Neel n  & J. Gookin n 

TL;DR: It is suggested that additional studies to determine if C. guttulatus is a potential cause or consequence of gastrointestinal illness in dogs may be warranted. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2016 journal article

Impact of microbial derived secondary bile acids on colonization resistance against Clostridium difficile in the gastrointestinal tract

ANAEROBE, 41, 44–50.

By: J. Winston n & C. Theriot n

author keywords: Clostridium difficile; Secondary bile acids; Colonization resistance; Gut microbiota; Antibiotics
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Anti-Bacterial Agents / therapeutic use; Bile Acids and Salts / pharmacology; Bile Acids and Salts / physiology; Clostridioides difficile / drug effects; Clostridioides difficile / physiology; Disease Susceptibility; Drug Resistance, Neoplasm; Enterocolitis, Pseudomembranous / drug therapy; Enterocolitis, Pseudomembranous / microbiology; Gastrointestinal Microbiome; Gastrointestinal Tract / microbiology; Humans
TL;DR: Rational manipulation of secondary bile acids may prove beneficial as a treatment for patients with CDI and shed light on how bile acid play a role in colonization resistance against C. difficile. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

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