Jenessa A. Winston

Works (8)

Updated: April 25th, 2025 12:49

2021 article

Secondary bile acid ursodeoxycholic acid alters weight, the gut microbiota, and the bile acid pool in conventional mice

Winston, J. A., Rivera, A., Cai, J., Patterson, A. D., & Theriot, C. M. (2021, February 18). PLoS ONE.

By: J. Winston n, A. Rivera n, J. Cai *, A. Patterson * & C. Theriot n

MeSH headings : Animals; Body Weight / drug effects; Cecum / microbiology; Feces / microbiology; Female; Gastrointestinal Microbiome / drug effects; Ileum / microbiology; Male; Metabolome / drug effects; Mice, Inbred C57BL; Receptors, Cytoplasmic and Nuclear / metabolism; Receptors, G-Protein-Coupled / metabolism; Ursodeoxycholic Acid / administration & dosage; Ursodeoxycholic Acid / pharmacology; Weight Loss / drug effects
topics (OpenAlex): Gut microbiota and health; Gastrointestinal motility and disorders; Clostridium difficile and Clostridium perfringens research
TL;DR: This study is the first to provide a comprehensive view of how exogenously administered ursodiol shapes the healthy gastrointestinal ecosystem in conventional mice and how these changes in turn modify the host physiologic response are important. (via Semantic Scholar)
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Source: Web Of Science
Added: March 22, 2021

2020 article

Clostridioides difficile carriage in animals and the associated changes in the host fecal microbiota

Thanissery, R., McLaren, M. R., Rivera, A., Reed, A. D., Betrapally, N. S., Burdette, T., … Theriot, C. M. (2020, October 3). Anaerobe, Vol. 66.

By: R. Thanissery n, M. McLaren n , A. Rivera n, A. Reed n, N. Betrapally n, T. Burdette n, J. Winston n, M. Jacob n, B. Callahan n , C. Theriot n

author keywords: C. difficile; C. hiranonis; Microbiome; Ribotype; Antibiotic resistance; Animal; Canine; Equine; Feline
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Bacterial Toxins / genetics; Bacterial Toxins / metabolism; Bacterial Typing Techniques; Cats; Chlorocebus aethiops; Clostridioides difficile / classification; Clostridioides difficile / drug effects; Clostridioides difficile / physiology; Clostridium Infections / epidemiology; Clostridium Infections / microbiology; Clostridium Infections / veterinary; Coculture Techniques; Dogs; Feces / microbiology; Female; Gastrointestinal Microbiome; Horses; Hospitals, Animal; Host-Pathogen Interactions; Male; Microbial Interactions; Microbial Sensitivity Tests; North Carolina; Polymerase Chain Reaction; Prevalence; RNA, Ribosomal, 16S; Ribotyping; Risk Factors; Tertiary Healthcare; Vero Cells
topics (OpenAlex): Clostridium difficile and Clostridium perfringens research; Gut microbiota and health; Gastrointestinal motility and disorders
TL;DR: Experimental results showed a clear antagonistic relationship between the two strains in vitro, suggesting that commensal Clostridia might play a role in colonization resistance against C. difficile in different hosts. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: January 11, 2021

2020 article

Ursodeoxycholic Acid (UDCA) Mitigates the Host Inflammatory Response during Clostridioides difficile Infection by Altering Gut Bile Acids

Winston, J. A., Rivera, A. J., Cai, J., Thanissery, R., Montgomery, S. A., Patterson, A. D., & Theriot, C. M. (2020, March 24). Infection and Immunity.

By: J. Winston n, A. Rivera n, J. Cai *, R. Thanissery n, S. Montgomery*, A. Patterson *, C. Theriot n

author keywords: C. difficile; FXR; UDCA; bile acids; inflammation; microbiome; ursodiol
MeSH headings : Animals; Bile Acids and Salts / metabolism; Biomarkers; Clostridioides difficile / drug effects; Clostridium Infections / drug therapy; Clostridium Infections / genetics; Clostridium Infections / metabolism; Clostridium Infections / microbiology; Computational Biology / methods; Dose-Response Relationship, Drug; Fibroblast Growth Factors / metabolism; Fragile X Mental Retardation Protein / metabolism; Gastrointestinal Microbiome / drug effects; Gene Expression Profiling; Host-Pathogen Interactions / drug effects; Host-Pathogen Interactions / genetics; Humans; Life Cycle Stages; Mice; Signal Transduction; Transcriptome; Ursodeoxycholic Acid / pharmacology; Ursodeoxycholic Acid / physiology
topics (OpenAlex): Clostridium difficile and Clostridium perfringens research; Helicobacter pylori-related gastroenterology studies; Microscopic Colitis
TL;DR: Although ursodiol pretreatment did not result in a consistent decrease in the C. difficile life cycle in vivo, it was able to attenuate an overly robust inflammatory response that is detrimental to the host during CDI. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: June 15, 2020

2019 article

Diversification of host bile acids by members of the gut microbiota

Winston, J. A., & Theriot, C. M. (2019, October 9). Gut Microbes.

By: J. Winston n & C. Theriot n

author keywords: C. difficile; bile acids; gut microbiota; ursodeoxycholic acid (UDCA); FXR
MeSH headings : Animals; Bacteria / metabolism; Bile Acids and Salts / biosynthesis; Bile Acids and Salts / metabolism; Cholesterol / metabolism; Clostridioides difficile / pathogenicity; Gastrointestinal Microbiome / drug effects; Gastrointestinal Microbiome / physiology; Hepatocytes / metabolism; Humans; Lipid Metabolism; Microbiota / drug effects; Receptors, Cytoplasmic and Nuclear / metabolism; Ursodeoxycholic Acid / pharmacology
topics (OpenAlex): Gut microbiota and health; Drug Transport and Resistance Mechanisms; Clostridium difficile and Clostridium perfringens research
TL;DR: The physiologic aspects of collaborative bile acid metabolism by the host and gut microbiota are described and the effects of ursodeoxycholic acid (UDCA) administration, a common therapeutic bile acids administration, on the gut microbiota-bile acid-host axis are discussed. (via Semantic Scholar)
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Source: Web Of Science
Added: March 30, 2020

2017 article

Inhibition of spore germination, growth, and toxin activity of clinically relevant C. difficile strains by gut microbiota derived secondary bile acids

Thanissery, R., Winston, J. A., & Theriot, C. M. (2017, March 7). Anaerobe.

By: R. Thanissery n, J. Winston n & C. Theriot n

author keywords: C. difficile; Bile acids; Gut microbiota; Metabolome; Germination; Growth; Toxin
MeSH headings : Animals; Anti-Bacterial Agents / metabolism; Antibiosis; Bacterial Toxins / metabolism; Bile Acids and Salts / metabolism; Clostridioides difficile / drug effects; Clostridioides difficile / growth & development; Gastrointestinal Microbiome; Gastrointestinal Tract / microbiology; Humans; Mice; Spores, Bacterial / drug effects; Spores, Bacterial / growth & development
topics (OpenAlex): Clostridium difficile and Clostridium perfringens research; Microscopic Colitis; Gastrointestinal motility and disorders
TL;DR: It is shown how clinically relevant C. difficile strains can have different responses when exposed to SBAs present in the gastrointestinal tract, and how these responses vary across all strains and ribotypes. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2016 article

Cefoperazone-treated Mouse Model of Clinically-relevant <em>Clostridium difficile</em> Strain R20291

Winston, J. A., Thanissery, R., Montgomery, S. A., & Theriot, C. M. (2016, December 10). Journal of Visualized Experiments.

By: J. Winston n, R. Thanissery n, S. Montgomery * & C. Theriot n

author keywords: Infection; Issue 118; Clostridium difficile; mouse model; antibiotic; colonization; cytotoxicity; histology; inflammation; Vero cells
MeSH headings : Animals; Anti-Bacterial Agents; Cefoperazone / pharmacology; Clostridioides difficile / drug effects; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL
topics (OpenAlex): Clostridium difficile and Clostridium perfringens research; Viral gastroenteritis research and epidemiology
TL;DR: This cefoperazone mouse model of CDI proves a valuable experimental platform to assess the effects of novel therapeutics on the amelioration of clinical disease and on the restoration of colonization resistance against C. difficile. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 article

Impact of microbial derived secondary bile acids on colonization resistance against Clostridium difficile in the gastrointestinal tract

Winston, J. A., & Theriot, C. M. (2016, May 8). Anaerobe.

By: J. Winston n & C. Theriot n

author keywords: Clostridium difficile; Secondary bile acids; Colonization resistance; Gut microbiota; Antibiotics
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Anti-Bacterial Agents / therapeutic use; Bile Acids and Salts / pharmacology; Bile Acids and Salts / physiology; Clostridioides difficile / drug effects; Clostridioides difficile / physiology; Disease Susceptibility; Drug Resistance, Neoplasm; Enterocolitis, Pseudomembranous / drug therapy; Enterocolitis, Pseudomembranous / microbiology; Gastrointestinal Microbiome; Gastrointestinal Tract / microbiology; Humans
topics (OpenAlex): Clostridium difficile and Clostridium perfringens research; Gut microbiota and health; Helicobacter pylori-related gastroenterology studies
TL;DR: Rational manipulation of secondary bile acids may prove beneficial as a treatment for patients with CDI and shed light on how bile acid play a role in colonization resistance against C. difficile. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2015 article

Cyniclomyces guttulatus Infection in Dogs: 19 Cases (2006–2013)

Winston, J. A., Piperisova, I., Neel, J., & Gookin, J. L. (2015, November 25). Journal of the American Animal Hospital Association, Vol. 52, pp. 42–51.

By: J. Winston n, I. Piperisova n, J. Neel n  & J. Gookin n 

Contributors: J. Winston n, I. Piperisova n, J. Neel n  & J. Gookin n 

MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Ascomycota; Dog Diseases / microbiology; Dogs; Feces / microbiology; Female; Male; Mycoses / microbiology; Mycoses / veterinary; Retrospective Studies
topics (OpenAlex): Plant Disease Resistance and Genetics; Yeasts and Rust Fungi Studies; Fungal Infections and Studies
TL;DR: It is suggested that additional studies to determine if C. guttulatus is a potential cause or consequence of gastrointestinal illness in dogs may be warranted. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

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