Jinxin Fan

Works (5)

Updated: April 13th, 2024 05:01

2024 journal article

Novel multimodal cation-exchange membrane for the purification of a single-chain variable fragment from Pichia pastoris supernatant

JOURNAL OF CHROMATOGRAPHY A, 1718.

By: D. Pham *, M. Linova *, W. Smith n, H. Brown  n, D. Elhanafi n, J. Fan n, J. Lavoie n, J. Woodley *, R. Carbonell n

author keywords: Multimodal ligand; Membrane chromatography; Nonwoven membranes; Single-chain variable fragment (scFv); Pichia pastoris fermentation
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Source: Web Of Science
Added: April 8, 2024

2023 article

Advances in high-throughput, high-capacity nonwoven membranes for chromatography in downstream processing: A review

Lavoie, J., Fan, J., Pourdeyhimi, B., Boi, C., & Carbonell, R. G. (2023, May 31). BIOTECHNOLOGY AND BIOENGINEERING, Vol. 5.

By: J. Lavoie n, J. Fan n, B. Pourdeyhimi n , C. Boi n  & R. Carbonell n

author keywords: downstream purification; fibrous systems; membrane adsorbers; membrane chromatography; nonwovens; product capture and polishing
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 19, 2023

2023 journal article

Purification of a monoclonal antibody using a novel high-capacity multimodal cation exchange nonwoven membrane

Separation and Purification Technology, 317, 123920.

By: J. Fan n, S. Sripada n, D. Pham *, M. Linova *, J. Woodley *, S. Menegatti n , C. Boi n , R. Carbonell n

author keywords: Salt-tolerant multimodal ligand; Membrane adsorber; Membrane chromatography; Nonwoven membranes; Monoclonal antibodies (mAbs); High-risk HCPs
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Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: June 5, 2023

2022 journal article

Purification of Adeno-Associated Virus (AAV) Serotype 2 from Spodoptera frugiperda (Sf9) Lysate by Chromatographic Nonwoven Membranes

Membranes, 12(10), 944.

By: J. Fan n, E. Barbieri n, S. Shastry n, S. Menegatti n , C. Boi n  & R. Carbonell n

author keywords: adeno-associated virus (AAV); viral vector purification; nonwovens; membrane adsorber; anion exchange; cation exchange; membrane chromatography
TL;DR: A strong anion-exchange membrane was developed by UV grafting glycidyl methacrylate on a polybutylene terephthalate nonwoven followed by functionalization with triethylamine, resulting in a quaternary amine ligand (AEX-TEA membrane) that exhibited a high AAV2 binding capacity and achieved excellent DNA clearance and a recovery of infectivity higher that that reported using ion-ex exchange resin chromatography. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: November 14, 2022

2021 journal article

Iminodiacetic Acid (IDA) Cation-Exchange Nonwoven Membranes for Efficient Capture of Antibodies and Antibody Fragments

Membranes, 11(7), 530.

By: J. Fan n, C. Boi n , S. Lemma n, J. Lavoie n & R. Carbonell n

author keywords: membrane adsorbers; membrane chromatography; nonwoven membranes; cation-exchange; UV grafting; monoclonal antibodies (mAbs); single-chain variable fragment (scFv)
TL;DR: There is significant evidence that this weak cation-exchange nonwoven fabric platform might be a suitable alternative to packed resin chromatography for low-cost, higher productivity manufacturing of therapeutic mAbs and antibody fragments. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 2, 2021

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