Jonathon F Fleming

College of Sciences

Works (7)

Updated: June 21st, 2025 05:02

2025 article

A novel approach for measuring allostatic load highlights differences in stress burdens due to race, sex and smoking status

Bailey, A., Payton, A., Fleming, J., Rager, J. E., & Jaspers, I. (2025, June 2). PLoS ONE.

By: A. Bailey *, A. Payton*, J. Fleming n, J. Rager * & I. Jaspers *

MeSH headings : Humans; Female; Allostasis / physiology; Male; Adult; Stress, Psychological / blood; Stress, Psychological / physiopathology; Stress, Psychological / ethnology; Middle Aged; Smoking; Biomarkers / blood; Sex Factors; Blood Pressure / physiology; Hydrocortisone / blood; Young Adult; Epinephrine / blood; White People
topics (OpenAlex): Climate Change and Health Impacts; Stress Responses and Cortisol; Thermoregulation and physiological responses
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: June 16, 2025

2024 article

Streamlining Phenotype Classification and Highlighting Feature Candidates: A Screening Method for Non-Targeted Ion Mobility Spectrometry-Mass Spectrometry (IMS-MS) Data

Chappel, J. R., Kirkwood-Donelson, K. I., Dodds, J. N., Fleming, J., Reif, D. M., & Baker, E. S. (2024, September 18). Analytical Chemistry, Vol. 9.

By: J. Chappel n, K. Kirkwood-Donelson *, J. Dodds*, J. Fleming n, D. Reif*  & E. Baker* 

MeSH headings : Ion Mobility Spectrometry / methods; Mass Spectrometry / methods; Phenotype; Chromatography, Liquid / methods; Support Vector Machine; Humans
topics (OpenAlex): Metabolomics and Mass Spectrometry Studies; Mass Spectrometry Techniques and Applications; Isotope Analysis in Ecology
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Sources: Web Of Science, NC State University Libraries
Added: September 30, 2024

2023 article

Aggregated Molecular Phenotype Scores: Enhancing Assessment and Visualization of Mass Spectrometry Imaging Data for Tissue-Based Diagnostics

Chappel, J. R., King, M. E., Fleming, J., Eberlin, L. S., Reif, D. M., & Baker, E. S. (2023, August 14). Analytical Chemistry, Vol. 8.

By: J. Chappel n, M. King*, J. Fleming n, L. Eberlin *, D. Reif*  & E. Baker* 

MeSH headings : Humans; Diagnostic Imaging / methods; Spectrometry, Mass, Electrospray Ionization / methods; Neoplasms / diagnostic imaging; Metabolomics; Phenotype; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Molecular Imaging / methods
topics (OpenAlex): Metabolomics and Mass Spectrometry Studies; Mass Spectrometry Techniques and Applications; Advanced Proteomics Techniques and Applications
TL;DR: Initial comparisons of cancerous human tissues to their normal or benign counterparts illustrated that AMP scores distinguished phenotypes with high accuracy, sensitivity, and specificity, leading to high diagnostic accuracy and interpretability. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 28, 2023

2023 article

Guided optimization of ToxPi model weights using a Semi-Automated approach

Fleming, J. F., House, J. S., Chappel, J. R., Motsinger-Reif, A. A., & Reif, D. M. (2023, December 9). Computational Toxicology, Vol. 29.

By: J. Fleming n, J. House* , J. Chappel n, A. Motsinger-Reif* & D. Reif n 

author keywords: Machine learning; Feature weighting; Exposure assessment; Chemical toxicity; Ordinal regression; Genetic algorithm
topics (OpenAlex): Computational Drug Discovery Methods
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UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: January 16, 2024

2022 article

Convergent evolution of polyploid genomes from across the eukaryotic tree of life

Hao, Y., Fleming, J., Petterson, J., Lyons, E., Edger, P. P., Pires, J. C., … Conant, G. C. (2022, April 22). G3 Genes Genomes Genetics, Vol. 5.

By: Y. Hao *, J. Fleming n, J. Petterson n, E. Lyons *, P. Edger *, J. Pires *, J. Thorne n, G. Conant n 

author keywords: polyploidy; convergent evolution; reciprocal gene loss; evolutionary model
MeSH headings : Diploidy; Eukaryota; Evolution, Molecular; Humans; Phylogeny; Polyploidy
topics (OpenAlex): Chromosomal and Genetic Variations; Genomics and Phylogenetic Studies; Protist diversity and phylogeny
TL;DR: By modeling the homoeologous gene losses that occurred in 50 genomes deriving from ten distinct polyploidy events, it is shown that the evolutionary forces acting on polyploids are remarkably similar, regardless of whether they occur in flowering plants, ciliates, fishes, or yeasts. (via Semantic Scholar)
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13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: May 23, 2022

2022 article

ToxPi*GIS Toolkit: creating, viewing, and sharing integrative visualizations for geospatial data using ArcGIS

Fleming, J., Marvel, S. W., Supak, S., Motsinger-Reif, A. A., & Reif, D. M. (2022, April 26). Journal of Exposure Science & Environmental Epidemiology, Vol. 4.

By: J. Fleming n, S. Marvel n, S. Supak n , A. Motsinger-Reif* & D. Reif n 

author keywords: Visual analytics; Geographic information systems; Data integration
MeSH headings : Humans; Geographic Information Systems; COVID-19
topics (OpenAlex): Data-Driven Disease Surveillance; Data Visualization and Analytics; Geographic Information Systems Studies
TL;DR: The integration of ToxPi profiles with ArcGIS provides new avenues for geospatial analysis, visualization, and public sharing of multi-factor data that can support decisions that help address issues such as disease prevention, environmental health, natural disaster prevention, chemical risk, and many others. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: May 10, 2022

2022 article

Utilizing Pine Needles to Temporally and Spatially Profile Per- and Polyfluoroalkyl Substances (PFAS)

Kirkwood, K. I., Fleming, J., Nguyen, H., Reif, D. M., Baker, E. S., & Belcher, S. M. (2022, February 17). Environmental Science & Technology, Vol. 2.

By: K. Kirkwood n, J. Fleming n, H. Nguyen  n, D. Reif n , E. Baker n  & S. Belcher n 

author keywords: Biomonitoring; contamination; per- and polyfluoroalkyl substances; fluoroethers; ion mobility; mass spectrometry; PFAS
MeSH headings : Alkanesulfonic Acids / analysis; Chromatography, Liquid; Fluorocarbons / analysis; United States; United States Environmental Protection Agency
topics (OpenAlex): Per- and polyfluoroalkyl substances research; Atmospheric chemistry and aerosols; Toxic Organic Pollutants Impact
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 18, 2022

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