@article{wallace_grimes_edwards_lux_tam_dickerson_carroll_scharf_colberg_kudej_et al._2022, title={Dogs >= five years of age at the time of congenital extrahepatic portosystemic shunt diagnosis have better long-term outcomes with surgical attenuation than with medical management alone}, volume={260}, ISSN={["1943-569X"]}, DOI={10.2460/javma.21.09.0417}, abstractNote={OBJECTIVE
To determine the outcome in dogs diagnosed with congenital extrahepatic portosystemic shunts (EHPSS) at ≥ 5 years of age treated with medical management only (M) or with surgical attenuation (S). The hypothesis was that dogs undergoing surgical attenuation would have a longer survival time than dogs undergoing medical management only.


ANIMALS
351 dogs definitively diagnosed with EHPSS at ≥ 5 years of age.


PROCEDURES
Medical records from 2009 to 2019 at 16 veterinary teaching hospitals were evaluated. Data collected included signalment, clinical signs at diagnosis, clinicopathologic data, surgical and medical treatments, shunt morphology, clinical signs and medical treatments at 6 to 12 months after diagnosis, and survival time.


RESULTS
351 dogs (M, 119 [33.9%]; S, 232 [66.1%]) were included in the study. Survival time was longer with surgery than medical management (hazard ratio, 4.2; M, 3.4 years; S, 10.9 years). Continued clinical signs at 6 to 12 months after diagnosis were more common with medical management (M, 40% [33/88]; S, 14% [21/155]). Continued medical treatments at 6 to 12 months after diagnosis were more common in the medical management group (M, 78% [69/88]; S, 34% [53/155]). Perioperative mortality rate was 7.3%.


CLINICAL RELEVANCE
Dogs diagnosed at ≥ 5 years of age with EHPSS have significantly better survival times and fewer clinical signs with surgical attenuation, compared with medical management. Older dogs have similar surgical mortality rates to dogs of all ages after surgical EHPSS attenuation.}, number={7}, journal={JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION}, author={Wallace, Mandy L. and Grimes, Janet A. and Edwards, Lauren and Lux, Cassie N. and Tam, Candace and Dickerson, Vanna M. and Carroll, Kenneth A. and Scharf, Valery F. and Colberg, Valerie and Kudej, Raymond K. and et al.}, year={2022}, month={Apr}, pages={758–764} }
 @article{erickson_regier_watt_ham_marvel_wallace_colopy_scharf_zheng_dugat_et al._2021, title={Incidence, survival time, and surgical treatment of parathyroid carcinomas in dogs: 100 cases (2010-2019)}, volume={259}, ISSN={["1943-569X"]}, DOI={10.2460/javma.20.06.0335}, abstractNote={OBJECTIVE
To evaluate outcomes of dogs with parathyroid carcinoma (PTC) treated by surgical excision and to describe the incidence of postoperative hypocalcemia, degree of hypocalcemia, duration of hospitalization, duration of calcium supplementation, and survival time.


ANIMALS
100 client-owned dogs with PTC admitted to academic, referral veterinary institutions.


PROCEDURES
In a retrospective multi-institutional study, medical records of dogs undergoing surgical excision of PTC between 2010 to 2019 were reviewed. Signalment, relevant medical history, clinical signs, clinicopathologic testing, imaging, surgical findings, intraoperative complications, histologic examination, and survival time were recorded.


RESULTS
100 dogs with PTC were included, and 96 dogs had clinical or incidental hypercalcemia. Common clinical signs included polyuria (44%), polydipsia (43%), hind limb paresis (22%), lethargy (21%), and hyporexia (20%). Cervical ultrasonography detected a parathyroid nodule in 91 of 91 dogs, with a single nodule in 70.3% (64/91), 2 nodules in 25.3% (23/91), and ≥ 3 nodules in 4 (4/91)% of dogs. Hypercalcemia resolved in 89 of 96 dogs within 7 days after surgery. Thirty-four percent of dogs developed hypocalcemia, on the basis of individual analyzer ranges, within 1 week after surgery. One dog had metastatic PTC to the prescapular lymph node, and 3 dogs were euthanized for refractory postoperative hypocalcemia. Estimated 1-, 2-, and 3-year survival rates were 84%, 65%, and 51% respectively, with a median survival time of 2 years.


CONCLUSIONS AND CLINICAL RELEVANCE
Excision of PTC results in resolution of hypercalcemia and excellent long-term tumor control. Surgical excision of PTC is recommended because of resolution of hypercalcemia and a good long-term prognosis. Future prospective studies and long-term follow-up are needed to further assess primary tumor recurrence, metastasis, and incidence of postoperative hypocalcemia.}, number={11}, journal={JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION}, author={Erickson, Andrea K. and Regier, Penny J. and Watt, Meghan M. and Ham, Kathleen M. and Marvel, Sarah J. and Wallace, Mandy L. and Colopy, Sara A. and Scharf, Valery F. and Zheng, Junxian and Dugat, Danielle R. and et al.}, year={2021}, month={Dec}, pages={1309–1317} }
 @article{moore_caughey_meyer_emmett_jacobs_chopra_howard_gallippi_2018, title={IN VIVO VISCOELASTIC RESPONSE (VISR) ULTRASOUND FOR CHARACTERIZING MECHANICAL ANISOTROPY IN LOWER-LIMB SKELETAL MUSCLES OF BOYS WITH AND WITHOUT DUCHENNE MUSCULAR DYSTROPHY}, volume={44}, ISSN={["1879-291X"]}, DOI={10.1016/j.ultrasmedbio.2018.07.004}, abstractNote={Our group has previously found that in silico, mechanical anisotropy may be interrogated by exciting transversely isotropic materials with geometrically asymmetric acoustic radiation force excitations and then monitoring the associated induced displacements in the region of excitation. We now translate acoustic radiation force-based anisotropy assessment to human muscle in vivo and investigate its clinical relevance to monitoring muscle degeneration in Duchenne muscular dystrophy (DMD). Clinical anisotropy assessments were performed using Viscoelastic Response ultrasound, with a degree of anisotropy reflected by the ratios of Viscoelastic Response relative elasticity (RE) or relative viscosity (RV) measured with the asymmetric radiation force oriented parallel versus perpendicular to muscle fiber alignment. In vivo results from rectus femoris and gastrocnemius muscles of boys aged ∼7.9–10.4 y indicate that RE and RV anisotropy ratios in rectus femoris muscles of boys with DMD were significantly higher than those of healthy control boys (RE: DMD = 1.51 ± 0.87, control = 0.99 ± 0.69, p = 0.04, Wilcoxon rank sum test; RV: DMD = 1.04 ± 0.71, control = 0.74 ± 0.22, p = 0.02). In the gastrocnemius muscle, only the RV anisotropy ratio was significantly higher in dystrophic than control patients (DMD = 1.23 ± 0.35, control = 0.88 ± 0.31, p = 0.04). In the dystrophic rectus femoris muscle, the RE anisotropy ratio was inversely correlated (slope = –0.03/lbf, r = –0.43, p = 0.07, Pearson correlation) with quantitative muscle testing functional output measures but was not correlated with quantitative muscle testing in the dystrophic gastrocnemius. These results suggest that Viscoelastic Response RE and RV measures reflect differences in mechanical anisotropy associated with functional impairment with dystrophic degeneration that are relevant to monitoring DMD clinically.}, number={12}, journal={ULTRASOUND IN MEDICINE AND BIOLOGY}, author={Moore, Christopher J. and Caughey, Melissa C. and Meyer, Diane O. and Emmett, Regina and Jacobs, Catherine and Chopra, Manisha and Howard, James F., Jr. and Gallippi, Caterina M.}, year={2018}, month={Dec}, pages={2519–2530} }