Works (66)

Updated: April 4th, 2024 09:44

2024 article

Impact of progesterone signaling on tumor necrosis factor-alpha synthesis by luteal macrophages

Giurgis, M., McCann-Deshazer, M., Gadsby, J. E., & Poole, D. H. (2024, March 2). JOURNAL OF ANIMAL SCIENCE, Vol. 102, pp. 55–56.

By: M. Giurgis n, M. McCann-Deshazer n, J. Gadsby n & D. Poole n

author keywords: Luteolysis; Macrophage; Progesterone
TL;DR: Collectively, TRIL treatment effectively reduced P4 synthesis in LC cultures, and the greater concentration of TRIL is needed for P4 suppression in longer term culture systems. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: March 25, 2024

2021 journal article

Plasma metabolomic profiling of healthy pregnant mares and mares with experimentally induced placentitis

Equine Veterinary Journal, 53(1), 85–93.

By: T. Beachler n, H. Gracz n, D. Morgan n, S. Bembenek Bailey n, L. Borst n, K. Ellis n, K. Von Dollen n, S. Lyle n ...

author keywords: horse; placentitis; diagnosis; plasma; NMR spectroscopy; metabolomics
MeSH headings : Animals; Female; Horse Diseases; Horses; Metabolomics; Placenta Diseases / veterinary; Plasma; Pregnancy; Streptococcus equi
TL;DR: Two phases of metabolite changes were noted after experimental infection: An immediate rise in metabolite concentration involved in energy, nitrogen, hydrogen, and oxygen metabolism within 4 hours after inoculation that was followed by a decrease in metabolites involved inenergy and nitrogen metabolism at 4 days, coinciding with ultrasonographic diagnosis of placentitis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: April 27, 2020

2020 journal article

Metabolomic Profile of Allantoic and Amniotic Fluid in Late-term Gestational Mares Characterized by H-1-nuclear Magnetic Resonance Spectroscopy

JOURNAL OF EQUINE VETERINARY SCIENCE, 94.

By: T. Beachler n, C. Bailey n, H. Gracz n, D. Morgan n, K. Von Dollen n, K. Ellis n, J. Gadsby n, S. Lyle n

author keywords: Equine; Metabolomics; Allantoic; Amniotic; Nuclear magnetic resonance spectroscopy
MeSH headings : Allantois; Amniotic Fluid; Animals; Body Fluids; Female; Horses; Magnetic Resonance Spectroscopy; Pregnancy; Protons
TL;DR: The goal of this study was to characterize the global metabolomic profile of equine allantoic and amniotic fluid through nuclear magnetic resonance spectroscopy offetal fluids from 12 pregnancies through ultrasound-guided transabdominal puncture. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 24, 2020

2019 journal article

Allantoic Metabolites, Progesterone, and Estradiol-17 beta Remain Unchanged After Infection in an Experimental Model of Equine Ascending Placentitis

JOURNAL OF EQUINE VETERINARY SCIENCE, 73, 95–105.

By: T. Beachler n, H. Gracz n, N. Long*, L. Borst n, D. Morgan n, A. Nebel n, N. Andrews n, J. Koipillai n ...

author keywords: Equine; Ascending placentitis; Metabolomics; Allantoic fluid
TL;DR: The results of this study established a database of equine allantoic fluid metabolites and confirmed the utility of uteroplacental ultrasound for detection of placentitis before the onset of hematologic changes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: February 11, 2019

2019 journal article

Progesterone inhibits cytokine/TNF-α production by porcine CL macrophages via the genomic progesterone receptor

Domestic Animal Endocrinology, 12, 106426.

By: J. Gadsby n, S. Frandsen n, J. Chang n, B. Celestino n, E. Tucker n & D. Poole n

author keywords: Pig; Corpus luteum; Progesterone; TNF-alpha; Macrophages; Cytokines
MeSH headings : Animals; Cells, Cultured; Cytokines / genetics; Cytokines / metabolism; Dose-Response Relationship, Drug; Gene Expression Regulation / drug effects; Genomics; Macrophages / drug effects; Macrophages / metabolism; Progesterone / administration & dosage; Progesterone / pharmacology; RNA, Messenger / genetics; RNA, Messenger / metabolism; Receptors, Progesterone / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Swine; Tumor Necrosis Factor-alpha / genetics; Tumor Necrosis Factor-alpha / metabolism
TL;DR: The hypothesis that P4 acting via the genomic P4 receptor (PGR) inhibits CL MAC TNF-α and thus plays a key role in regulating LS during the pig estrous cycle is examined and it is suggested that progesterone, acting via PGR, plays a critical physiological role in the control of T NF-α production by CL MACs and LS During the pig Estrous cycle. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries
Added: January 14, 2020

2018 chapter

Hormones Affecting Reproduction

In J. Riviere & M. Papich (Eds.), Veterinary Pharmacology and Therapeutics (10th ed., pp. 674–690). New Jersey, USA: Wiley.

By: W. Baeumer, C. Bailey & J. Gadsby

Ed(s): J. Riviere & M. Papich

Source: NC State University Libraries
Added: October 23, 2020

2018 journal article

Prostaglandin (PTG) E and F receptors in the porcine corpus luteum; effect of tumor necrosis factor-α

Animal Reproduction Science, 195, 139–148.

By: J. Chang n, S. Frandsen n, M. D’Annibale-Tolhurst n, N. Palumbo n & J. Gadsby n

author keywords: Pig; Corpus luteum; Prostaglandin receptors; TNF-alpha; Macrophages; Luteolytic sensitivity
MeSH headings : Animals; Corpus Luteum / drug effects; Estrous Cycle; Female; Gene Expression Regulation / drug effects; Luteal Cells; Prostaglandins E / administration & dosage; Prostaglandins E / pharmacology; Prostaglandins F / administration & dosage; Prostaglandins F / pharmacology; Receptors, Prostaglandin / genetics; Receptors, Prostaglandin / metabolism; Receptors, Prostaglandin E, EP2 Subtype / metabolism; Receptors, Prostaglandin E, EP3 Subtype / metabolism; Swine; Tumor Necrosis Factor-alpha / administration & dosage; Tumor Necrosis Factor-alpha / pharmacology
TL;DR: A role for PTGER-3/EP-3 in the acquisition of LS is suggested, and the hypothesis that TNF-α from CL macrophages plays a critical role in the control of LS in the porcine CL is supported. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, Web Of Science, NC State University Libraries
Added: January 25, 2020

2017 journal article

Prostaglandin synthesis by the porcine corpus luteum: effect of tumor necrosis factor-alpha

DOMESTIC ANIMAL ENDOCRINOLOGY, 58, 53–62.

By: J. Chang n, S. Frandsen n & J. Gadsby n

author keywords: Pig; Corpus luteum; Prostaglandin; Tumor necrosis factor-alpha; Macrophage; Luteolytic sensitivity
MeSH headings : Aldehyde Reductase / analysis; Aldehyde Reductase / genetics; Animals; Cells, Cultured; Corpus Luteum / drug effects; Corpus Luteum / metabolism; Cyclooxygenase 2 / genetics; Dinoprost / analysis; Dinoprost / biosynthesis; Dinoprost / pharmacology; Dinoprostone / analysis; Dinoprostone / biosynthesis; Dinoprostone / metabolism; Female; Luteal Cells / metabolism; Luteolysis / drug effects; Prostaglandin-E Synthases / analysis; Prostaglandin-E Synthases / genetics; Prostaglandins / biosynthesis; RNA, Messenger / analysis; Sus scrofa / metabolism; Tumor Necrosis Factor-alpha / pharmacology
TL;DR: Although TNF-α increased COX2 and mPGES-1 mRNA, and PGE-2 secretion in vitro, it did not increase the PGF-2α:PGE2 ratio, and studies are currently directed toward exploring other pathways by which T NF-α induces LS in the porcine CL. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Toll-like receptor and related cytokine mRNA expression in bovine corpora lutea during the oestrous cycle and pregnancy

REPRODUCTION IN DOMESTIC ANIMALS, 52(3), 495–504.

By: J. Gadsby n, A. Nipper n, H. Faircloth n, . M. D'Annibale-Tolhurst, J. Chang n, P. Farin n, I. Sheldon*, D. Poole n

MeSH headings : Animals; Cattle; Corpus Luteum / drug effects; Corpus Luteum / metabolism; Cytokines / genetics; Estrous Cycle / genetics; Estrous Cycle / metabolism; Female; Gene Expression Regulation; Lipopolysaccharides / pharmacology; Luteolysis / genetics; Pregnancy; Pregnancy, Animal / genetics; Pregnancy, Animal / metabolism; RNA, Messenger / genetics; RNA, Messenger / metabolism; Toll-Like Receptors / genetics; Toll-Like Receptors / metabolism
TL;DR: Based on data, one or more of the TLRs found within the CL may play a role in luteolysis, perhaps via pro-inflammatory cytokine mRNA expression. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 journal article

Expression of Genes Associated with Apoptosis in the Porcine Corpus Luteum During the Oestrous Cycle

REPRODUCTION IN DOMESTIC ANIMALS, 48(5), 755–761.

By: L. Zorrilla n, M. D'Annibale n, S. Swing n & J. Gadsby n

MeSH headings : Animals; Apoptosis / physiology; Corpus Luteum / metabolism; Estrous Cycle / physiology; Female; Gene Expression Regulation / physiology; Pregnancy; RNA, Messenger / genetics; RNA, Messenger / metabolism; Swine / physiology
TL;DR: It is concluded that apoptosis-associated proteins (i.e. Bcl-x and Caspase 3) may play a critical role in luteolytic sensitivity in the pig. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

Endothelin-1, endothelin converting enzyme-1 and endothelin receptors in the porcine corpus luteum

DOMESTIC ANIMAL ENDOCRINOLOGY, 38(2), 75–85.

By: L. Zorrilla*, R. Sriperumbudur* & J. Gadsby*

author keywords: Pig; Luteolytic sensitivity; Endothelin; Corpus luteum; Prostaglandin-F-2 alpha; Luteolysis
MeSH headings : Animals; Aspartic Acid Endopeptidases / analysis; Aspartic Acid Endopeptidases / genetics; Corpus Luteum / chemistry; Dinoprost / pharmacology; Endothelial Cells / chemistry; Endothelin-1 / analysis; Endothelin-1 / genetics; Endothelin-1 / physiology; Endothelin-Converting Enzymes; Estrous Cycle; Female; Fluorescent Antibody Technique; Gene Expression; Luteal Cells / chemistry; Luteolysis / drug effects; Luteolysis / physiology; Metalloendopeptidases / analysis; Metalloendopeptidases / genetics; Protein Precursors / analysis; Protein Precursors / genetics; Receptor, Endothelin A / analysis; Receptor, Endothelin A / genetics; Receptor, Endothelin A / physiology; Receptors, Endothelin / analysis; Receptors, Endothelin / genetics; Reverse Transcriptase Polymerase Chain Reaction; Swine
TL;DR: The observed elevation in ECE1 protein concentrations on day 10 and the presence of EDNRA on LLC suggests a possible role for EDN1 (resulting from the actions of E CE1) acting via EDN RA in the control of LS in the pig. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

Transforming growth factor-beta (TGF beta) and its signaling components in peni-ovulatory pig follicles

ANIMAL REPRODUCTION SCIENCE, 120(1-4), 84–94.

By: R. Sriperumbudur n, L. Zorrilla n & J. Gadsby n

author keywords: Pig; TGF beta; Peri-ovulatory follicles; Luteinization; Granulosa cells; Progesterone
MeSH headings : Animals; Aromatase / genetics; Aromatase / metabolism; Cells, Cultured; Female; Gene Expression Profiling; Ligands; Luteinization / blood; Luteinization / genetics; Luteinization / metabolism; Ovarian Follicle / metabolism; Ovarian Follicle / physiology; Ovulation / blood; Ovulation / genetics; Ovulation / metabolism; Phosphoproteins / genetics; Phosphoproteins / metabolism; Progesterone / blood; Progesterone / metabolism; Receptors, Transforming Growth Factor beta / genetics; Receptors, Transforming Growth Factor beta / metabolism; Signal Transduction / genetics; Signal Transduction / physiology; Smad Proteins / genetics; Smad Proteins / metabolism; Swine / genetics; Swine / metabolism; Swine / physiology; Time Factors; Transforming Growth Factor beta / blood; Transforming Growth Factor beta / genetics; Transforming Growth Factor beta / metabolism
TL;DR: Data from the present study on temporal and spatial patterns of expression of the TGFbeta-system suggest that TGF beta may play a role in the overall process of luteinization, but it appears not to influence steroidogenesis in lute inizing pig follicles. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 chapter

Hormones Affecting Reproduction

In J. Riviere & M. Papich (Eds.), Veterinary Pharmacology and Therapeutics (9th Edition, pp. 717–733). New York, USA: Blackwell.

By: D. Reddy & J. Gadsby

Ed(s): J. Riviere & M. Papich

Source: NC State University Libraries
Added: October 23, 2020

2009 article

Mechanisms of Infertility Associated with Clinical and Subclinical Endometritis in High Producing Dairy Cattle

Sheldon, I. M., Price, S. B., Cronin, J., Gilbert, R. O., & Gadsby, J. E. (2009, September). REPRODUCTION IN DOMESTIC ANIMALS, Vol. 44, pp. 1–9.

By: I. Sheldon*, S. Price*, J. Cronin*, R. Gilbert* & J. Gadsby n

MeSH headings : Animals; Anovulation / veterinary; Bacterial Infections; Cattle; Cattle Diseases / etiology; Cattle Diseases / immunology; Cattle Diseases / microbiology; Chemokines / metabolism; Cytokines / metabolism; Endometritis / immunology; Endometritis / microbiology; Endometritis / veterinary; Female; Infertility, Female / etiology; Infertility, Female / immunology; Infertility, Female / veterinary; Lactation; Lipopolysaccharides / immunology; Luteal Phase / physiology; Progesterone / blood; Toll-Like Receptors / immunology; Virus Diseases
TL;DR: LPS impairs the function of the hypothalamus and pituitary, and directly perturbs ovarian granulosa cells steroidogenesis, providing mechanisms to explain the association between uterine disease and anovulatory anoestrus. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 journal article

Protein kinase C isoforms in the porcine corpus luteum: Temporal and spatial expression patterns

DOMESTIC ANIMAL ENDOCRINOLOGY, 36(4), 173–185.

By: L. Zorrilla n, M. Irvin n & J. Gadsby n

author keywords: Corpus luteum; Protein kinase C; Pig; Luteolytic sensitivity; Prostaglandin-F-2 alpha
MeSH headings : Animals; Corpus Luteum / cytology; Corpus Luteum / enzymology; Estrous Cycle / metabolism; Female; Gene Expression Regulation / physiology; Isoenzymes / genetics; Isoenzymes / metabolism; Luteal Cells / enzymology; Luteinization / metabolism; Protein Kinase C / genetics; Protein Kinase C / metabolism; RNA, Messenger / analysis; Signal Transduction / physiology; Statistics, Nonparametric; Swine; Time Factors; Tissue Distribution
TL;DR: Since the increase in PRKCE protein expression occurred coincidentally with the onset of LS, these results support a potential role forPRKCE in control of the acquisition of LS in the pig. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

NMR studies of the inclusion complex of cloprostenol sodium salt with beta-cyclodextrin in aqueous solution

PHARMACEUTICAL RESEARCH, 25(5), 1142–1149.

By: H. Whang n, F. Vendeix n, H. Gracz n, J. Gadsby n & A. Tonelli n

author keywords: cloprostenol sodium salt; cyclodextrins; inclusion complexes; molecular modeling; nuclear magnetic resonance
MeSH headings : Chemical Phenomena; Chemistry, Physical; Cloprostenol / chemistry; Magnetic Resonance Spectroscopy; Models, Molecular; Solutions; beta-Cyclodextrins / chemistry
TL;DR: This is the first study of the inclusion complex of cloprostenol with β-cyclodextrin (β-CD) in aqueous solution using NMR and 3D molecular dynamics simulations and it is found that β-CD forms a 1:1 inclusion complex with clop Frostenol. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 chapter

The role of intra-luteal factors in the control of the porcine corpus luteum

In E. C. J. Ashworth & R. R. Kraeling (Eds.), Control of Pig Reproduction VII, Reproduction Supplement 62 (pp. 69–83). Nottingham, U.K: Nottingham University Press.

By: J. Gadsby, L. Rose, R. Sriperumbudur & Z. Ge

Ed(s): E. Ashworth & R. Kraeling

Source: NC State University Libraries
Added: October 23, 2020

2005 journal article

Expression and localization of hypoxia inducible factor-1 alpha mRNA in the porcine ovary

Canadian Journal of Veterinary Research, 69(3), 215–222.

By: U. Boonyaprakob, J. Gadsby, V. Hedgpeth, P. Routh & G. Almond

Source: NC State University Libraries
Added: August 6, 2018

2003 journal article

Cloning of pig prostaglandin F-2 alpha(FP) receptor cDNA and expression of its mRNA in the corpora lutea

Reproduction (Cambridge, England), 125(1), 53–64.

By: U. Boonyaprakob*, J. Gadsby*, V. Hedgpeth*, P. Routh* & G. Almond*

TL;DR: It is demonstrated that FPr is expressed in pig corpora lutea throughout the oestrous cycle and that upregulation of the FPr mRNA occurs when the corporaLutea becomes sensitive to PGF(2alpha). (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2003 journal article

Expression and localization of vascular endothelial growth factor and its receptors in pig corpora lutea during the oestrous cycle

Reproduction (Cambridge, England), 126(3), 393–405.

By: U. Boonyaprakob*, J. Gadsby*, V. Hedgpeth*, P. Routh* & G. Almond*

MeSH headings : Animals; Blotting, Northern / methods; Corpus Luteum / chemistry; Corpus Luteum / physiology; Estrous Cycle / physiology; Female; Follicular Phase / physiology; In Situ Hybridization / methods; Luteal Phase / physiology; RNA, Messenger / analysis; Receptors, Vascular Endothelial Growth Factor / genetics; Swine / physiology; Vascular Endothelial Growth Factor A / genetics; Vascular Endothelial Growth Factor Receptor-1 / genetics; Vascular Endothelial Growth Factor Receptor-2 / genetics
TL;DR: Data indicate that the VEGF system may be involved in the regulation of luteal vasculature throughout the lifespan of the corpus luteum, and variations in the expression of V EGFR-1 and VEGFR-2 mRNAs indicate that differential regulation of expression of the V EGF receptors may play a role in the control of VEGf-mediated vascular growth at different phases of development and maturation of the pig corpus lutenum. (via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2003 journal article

Insulin-like growth factor (IGF)-I and IGF binding proteins-2,-3,-4,-5 in porcine corpora lutea during the estrous cycle; evidence for inhibitory actions of IGFBP-3

DOMESTIC ANIMAL ENDOCRINOLOGY, 25(2), 183–197.

By: Z. Ge*, E. Miller*, W. Nicholson*, V. Hedgpeth* & J. Gadsby*

author keywords: IGF-I; IGFBP-3; progesterone; corpus luteum; pig
MeSH headings : Animals; Blotting, Western / veterinary; Corpus Luteum / chemistry; Corpus Luteum / metabolism; Estrous Cycle / metabolism; Female; Insulin-Like Growth Factor Binding Protein 3 / metabolism; Insulin-Like Growth Factor Binding Proteins / analysis; Insulin-Like Growth Factor Binding Proteins / metabolism; Insulin-Like Growth Factor I / analysis; Insulin-Like Growth Factor I / metabolism; Progesterone / metabolism; Radioimmunoassay / veterinary; Swine / physiology
TL;DR: It is concluded that IGFBP-3 inhibits IGF-I actions in the porcine CL in the estrous cycle and inhibited the steroidogenic actions of IGF, but had no significant actions alone. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2003 journal article

Steroidogenic responses of pig corpora lutea to insulin-like growth factor I (IGF-I) throughout the oestrous cycle

REPRODUCTION, 125(2), 241–249.

By: E. Miller n, Z. Ge n, V. Hedgpeth n & J. Gadsby n

TL;DR: IGF-I has steroidogenic actions only on 'young' (days 4-7) pig corpora lutea; endogenous IGF-I and IGFBP are insufficient to modulate progesterone secretion in vitro; and the steroidsogenic actions of IGF- I are mediated via PI-3-kinase. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2000 journal article

Insulin-like growth factor I receptor Mrna and protein expression in pig corpora lutea

Journal of Reproduction & Fertility, 120(1), 109–114.

By: Z. Ge n, W. Nicholson*, D. Plotner*, C. Farin* & J. Gadsby*

Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2000 journal article

Messenger ribonucleic acids for MAC25 and connective tissue growth factor (CTGF) are inversely regulated during folliculogenesis and early luteogenesis

ENDOCRINOLOGY, 141(7), 2648–2657.

By: S. Wandji*, J. Gadsby, J. Barber & J. Hammond

Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2000 journal article

Porcine ovarian cells express messenger ribonucleic acids for the acid-labile subunit and insulin-like growth factor binding protein-3 during follicular and luteal phases of the estrous cycle

ENDOCRINOLOGY, 141(7), 2638–2647.

By: S. Wandji*, J. Gadsby, F. Simmen, J. Barber & J. Hammond

Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1999 journal article

Insulin-like growth factor (IGF)-I, ICF-I receptor, and IGF binding protein-3 messenger ribonucleic acids and protein in corpora lutea from prostaglandin F-2 alpha-treated gilts

BIOLOGY OF REPRODUCTION, 61(6), 1527–1534.

By: W. Nicholson, Z. Ge*, D. Plotner*, C. Farin n & J. Gadsby*

MeSH headings : Animals; Blotting, Northern; Blotting, Western; Corpus Luteum / anatomy & histology; Corpus Luteum / drug effects; Corpus Luteum / metabolism; Dinoprost / pharmacology; Female; Insulin-Like Growth Factor Binding Protein 2 / metabolism; Insulin-Like Growth Factor Binding Protein 3 / genetics; Insulin-Like Growth Factor Binding Protein 3 / metabolism; Insulin-Like Growth Factor Binding Proteins / analysis; Insulin-Like Growth Factor I / analysis; Insulin-Like Growth Factor I / genetics; Insulin-Like Growth Factor I / metabolism; Organ Size; Progesterone / metabolism; RNA, Messenger / metabolism; Receptor, IGF Type 1 / genetics; Receptor, IGF Type 1 / metabolism; Swine / metabolism
TL;DR: PGF(2alpha)-induced premature luteolysis was associated with an increase in steady-state levels of IGF-IR mRNA, but it did not appear to be linked to changes in mRNA levels for IGF-I or IGFBP-3. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1999 journal article

Ovarian expression of Mac25/IGFBP-7 and connective tissue growth factor/IGFBP-8 during porcine follicular phase.

Biology of Reproduction, 60(1999), 173.

By: S. Wandji, J. Gadsby, J. Barber & J. Hammond

Source: NC State University Libraries
Added: August 6, 2018

1996 journal article

Expression of the Messenger Ribonucleic Acids for Insulin-Like Growth Factor-I and Insulin-Like Growth Factor Binding Proteins in Porcine Corpora Lutea

Biology of Reproduction, 54(2), 339–346.

By: J. Gadsby n, J. Lovdal n, S. Samaras*, J. Barber* & J. Hammond*

MeSH headings : Animals; Blotting, Northern; Corpus Luteum / metabolism; Female; Gene Expression; Insulin-Like Growth Factor Binding Protein 2 / genetics; Insulin-Like Growth Factor Binding Protein 3 / genetics; Insulin-Like Growth Factor Binding Protein 4 / genetics; Insulin-Like Growth Factor Binding Protein 5 / genetics; Insulin-Like Growth Factor Binding Protein 6 / genetics; Insulin-Like Growth Factor Binding Proteins / genetics; Insulin-Like Growth Factor I / genetics; RNA, Messenger / metabolism; Swine
TL;DR: It is concluded that porcine CL express mRNAs for IGF-I and IGFBP-2, -3, -4, and -5, and that while small luteal cells are the major sources of IGF-i and IGF BP-3 and - 5, IGFBP -2 and -4 appear to be expressed to approximately the same extent in small and large lutesal cells. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

1996 conference paper

Short-cycling of gilts with prostaglandin analogs

In P. G. Monetti & G. Vignola (Eds.), Proceedings of the 14th International Pig Veterinary Society Congress (p. 564). Bologna, Italy: Scientific Committee of the 14th IPVS Congress.

By: J. Gadsby, M. Grafinger & G. Almond

Ed(s): P. Monetti & G. Vignola

Event: 14th International Pig Veterinary Society Congress at Bologna, Italy on July 7-10, 1996

Source: NC State University Libraries
Added: October 23, 2020

1995 journal article

Does increased PGF2α receptor concentration mediate PGF2α-induced luteolysis during early diestrus in the pig?

Prostaglandins, 49(5), 255–267.

By: C. Estill n, J. Britt n & J. Gadsby n

author keywords: PGF(2-ALPHA); RECEPTOR; PORCINE; CORPUS LUTEUM; LUTEOLYSIS
MeSH headings : Animals; Corpus Luteum / drug effects; Corpus Luteum / physiology; Diestrus / physiology; Dinoprost / metabolism; Dinoprost / pharmacology; Estrus / drug effects; Female; Luteolysis / drug effects; Ovariectomy; Progesterone / metabolism; Receptors, Prostaglandin / physiology; Swine / physiology; Time Factors
TL;DR: It is concluded that PGF2α-induced premature luteolysis is not mediated by an increase in luteal PGF22α receptor concentrations and, based on lutesal progesterone concentrations and histological features, that the PGF 2α-based protocol used to shorten the estrous cycle is accompanied by premature functional and structural lutenal regression. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries
Added: January 14, 2020

1994 journal article

Differential effects of LH and PGE2 on progesterone secretion by small and large porcine luteal cells

Reproduction, 102(1), 27–34.

By: R. Richards n, J. Gadsby n & G. Almond n

MeSH headings : Animals; Cell Size / physiology; Cells, Cultured; Corpus Luteum / cytology; Corpus Luteum / drug effects; Corpus Luteum / metabolism; Dinoprostone / pharmacology; Dose-Response Relationship, Drug; Female; Hydrocortisone / pharmacology; Insulin / pharmacology; Lipoproteins, LDL / pharmacology; Luteinizing Hormone / pharmacology; Progesterone / metabolism; Stimulation, Chemical; Swine / physiology
TL;DR: It is demonstrated that progesterone secretion by porcine luteal cells is stimulated differentially by LH and PGE2 and that small lutenal cells are more responsive to LH andPGE2 acts primarily on large luteAl cells. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 14, 2020

1994 journal article

Prostaglandin F2a stimulates progesterone secretion by porcine luteal cells in vitro throughout the estrous cycle

Prostaglandins, 48(2), 109–125.

By: J. Gadsby n & K. Earnest n

author keywords: CORPUS LUTEUM; PIG; PROGESTERONE; PGF(2-ALPHA); A23187; PMA
MeSH headings : 3-Hydroxysteroid Dehydrogenases / antagonists & inhibitors; Animals; Calcimycin / pharmacology; Cells, Cultured; Corpus Luteum / cytology; Corpus Luteum / drug effects; Dihydrotestosterone / analogs & derivatives; Dihydrotestosterone / pharmacology; Dinoprost / pharmacology; Dose-Response Relationship, Drug; Estrus / metabolism; Female; Pregnancy; Progesterone / metabolism; Radioimmunoassay; Swine; Tetradecanoylphorbol Acetate / pharmacology; Time Factors
TL;DR: It is speculated that calcium/protein kinase C may be involved in mediating the stimulatory action of PGF2 alpha on luteal cell progesterone secretion as well as PGF1 alpha receptor concentrations, which are not measured in this study. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

1993 journal article

Prostaglandin F2α Receptor Concentrations in Corpora Lutea of Cycling, Pregnant, and Pseudopregnant Pigs

Biology of Reproduction, 49(3), 604–608.

By: J. Gadsby n, J. Lovdal n, J. Britt n & T. Fitz*

MeSH headings : Animals; Corpus Luteum / metabolism; Dinoprost / metabolism; Estrus / physiology; Female; Pregnancy; Pregnancy, Animal / metabolism; Pseudopregnancy / metabolism; Receptors, Prostaglandin / metabolism; Swine / metabolism
TL;DR: It is speculated that reduced luteal PGF 2 alpha receptor concentrations on Day 14 in pregnant and pseudopregnant compared with cycling pigs may lead to decreased luteAL sensitivity to PGF2 alpha in these animals, and that this mechanism may play a role in the maternal recognition of pregnancy in this species. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

1993 journal article

Repeated Administration of Prostaglandin F2α during the Early Luteal Phase Causes Premature Luteolysis in the Pig

Biology of Reproduction, 49(1), 181–185.

By: C. Estill n, J. Britt n & J. Gadsby n

MeSH headings : Animals; Dinoprost / administration & dosage; Estradiol / blood; Estrus / drug effects; Estrus / physiology; Female; Luteinizing Hormone / blood; Luteolysis / drug effects; Luteolysis / physiology; Ovariectomy; Ovary / physiology; Progesterone / blood; Swine; Time Factors
TL;DR: It is demonstrated that the pig is susceptible to the luteolytic effects of PGF2 alpha before Day 12 if repeated injections are given from Day 5 through Day 10, leading to significant shortening of the estrous cycle and interestrous interval. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, Web Of Science
Added: August 6, 2018

1992 journal article

The presence of glandular kallikrein in rabbit fetal placental conditioned medium.

Endocrinology, 131(4), 1777–1781.

By: K. Weerasinghe n & J. Gadsby n

MeSH headings : Animals; Blotting, Western; Chromogenic Compounds; Culture Media; Enzyme-Linked Immunosorbent Assay; Fetus; Kallikreins / metabolism; Kallikreins / urine; Oligopeptides; Pancreas / metabolism; Placenta / metabolism; Rabbits; Rats; Swine; Tissue Kallikreins
Sources: Crossref, NC State University Libraries
Added: January 14, 2020

1991 journal article

Acute stimulatory effects of prostaglandin F2α on serum progesterone concentrations in pregnant and pseudopregnant pigs

Prostaglandins, 41(5), 419–432.

By: J. Gadsby n, C. Smith n & G. Almond n

MeSH headings : Animals; Dinoprost / pharmacology; Female; Kinetics; Luteinizing Hormone / blood; Pregnancy; Pregnancy, Animal / blood; Progesterone / blood; Pseudopregnancy / blood; Reference Values; Swine
TL;DR: It is indicated that PGF2 alpha-injection produces a rapid and transient increase in serum progesterone concentrations which may result from a Rapid and direct stimulatory action of P GF2 alpha on porcine luteal cell progester one synthesis/secretion in vivo. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

1991 journal article

Luteal Enzymes of the Luteinizing Hormone and β-Adrenergic Signal Transduction Pathways in Hypophysectomized Rabbits do not Require Pituitary Hormone Support

Biology of Reproduction, 44(4), 609–619.

By: M. Hunzicker-Dunn*, A. Chen*, V. Jackiw*, J. Gadsby*, C. Bill*, A. LaBarbera*, J. Miller*, P. Landis Keyes*

MeSH headings : Animals; Corpus Luteum / enzymology; Corpus Luteum / physiology; Cyclic AMP / physiology; Female; Hypophysectomy; Luteinizing Hormone / physiology; Pituitary Gland / physiology; Pituitary Hormones / physiology; Pseudopregnancy / physiopathology; Rabbits; Receptors, Adrenergic, beta / physiology; Signal Transduction / physiology
TL;DR: It is concluded that expression of the proteins of the cAMP signal pathway for LH and beta-adrenergic hormones in CL of estrogen-treated rabbits does not require pituitary hormone support. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 14, 2020

1990 journal article

Prostaglandin F2α Receptors on Enzyme-Dissociated Pig Luteal Cells throughout the Estrous Cycle*

Endocrinology, 126(2), 787–795.

By: J. Gadsby n, A. Balapure n, J. Britt n & T. Fitz n

MeSH headings : Animals; Binding Sites; Corpus Luteum / metabolism; Dinoprost / analogs & derivatives; Dinoprost / metabolism; Dinoprostone / metabolism; Estrus / metabolism; Female; Luteal Cells / cytology; Luteal Cells / metabolism; Microbial Collagenase / metabolism; Prostaglandin D2 / metabolism; Receptors, Prostaglandin / metabolism; Swine
TL;DR: A deficiency of luteal cell prostaglandin F2α (PGF2α) receptors might help explain the well documented refractoriness of pig corpora lutea to the luteolytic effects of PGF2α administered in vivo before day 12 of the estrous cycle. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

1989 journal article

Control of corpus luteum function in the pregnant rabbit

Journal of Reproduction and Fertility Supplement, 37, 45–54.

By: J. Gadsby

Source: NC State University Libraries
Added: October 23, 2020

1989 journal article

Rabbit placental-conditioned medium stimulates progesterone accumulation by granulosa-lutein cells in culture: preliminary characterization of a placental luteotropic hormone

Biology of Reproduction, 40(2), 239–249.

By: J. Gadsby n & M. Lancaster

MeSH headings : Animals; Cell Count; Cells, Cultured; Corpus Luteum / metabolism; Culture Media / analysis; Culture Media / pharmacology; Dialysis; Estradiol / metabolism; Female; Granulosa Cells / metabolism; Hot Temperature; In Vitro Techniques; Luteal Cells / metabolism; Luteinizing Hormone / metabolism; Placenta / metabolism; Placental Hormones / isolation & purification; Placental Hormones / metabolism; Pregnancy; Progesterone / metabolism; Rabbits; Radioimmunoassay; Trypsin
TL;DR: Data indicate that FPI contains a luteotropic hormone/factor that is probably a heat-stable, trypsin-sensitive, protein/peptide of greater than 6000-8000 MW that acts in synergy with E2 to promote granulosa-lutein cell steroidogenesis, a good candidate for the elusive rabbit placental luteotropin. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 12, 2020

1987 chapter

Role of Estrogen and the Placenta in the Maintenance of the Rabbit Corpus Luteum

In Advances in Experimental Medicine and Biology (pp. 361–378).

By: P. Keyes* & J. Gadsby n

MeSH headings : Animals; Corpus Luteum / drug effects; Corpus Luteum / physiology; Estradiol / pharmacology; Estradiol / physiology; Estrogens / physiology; Female; Hypophysectomy; Hysterectomy; Placenta / physiology; Pregnancy; Progesterone / blood; Rabbits; Receptors, Estrogen / physiology
TL;DR: The mechanisms that are responsible for placental maintenance of luteal function are explored, with a brief summary of the literature setting the stage for the specific hypotheses and experiments reported herein. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 5, 2020

1985 journal article

Do Catecholamines Play a Physiologic Role in Regulating Corpus Luteum Function in the Pseudopregnant Rabbit?

Biology of Reproduction, 32(4), 907–915.

By: J. Gadsby*, P. Keyes, T. Schwartz, C. Bill & B. Lucchesi*

MeSH headings : Animals; Blood Pressure / drug effects; Catecholamines / physiology; Corpus Luteum / physiopathology; Female; Gonadotropin-Releasing Hormone / pharmacology; Hypophysectomy; Isoproterenol / pharmacology; Progesterone / blood; Propranolol / blood; Propranolol / pharmacology; Pseudopregnancy / physiopathology; Rabbits
TL;DR: It is concluded that endogenous catecholamines play no major role in regulating luteal steroidogenesis or corpus luteum regression in the pseudopregnant rabbit. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 23, 2020

1985 conference paper

Maintenance of rabbit luteal LH and catecholamine responsive adenylyl cyclase and cyclic AMP content does not require pituitary support

In R. J. Ryan & D. O. Toft (Eds.), Proceedings of the Fifth Ovarian Workshop (pp. 89–94). Champaign, Illinois: Ovarian Workshops.

By: M. Hunzicker-Dunn, J. Gadsby, C. Bill, A. LaBarbera, P. Keyes & J. Miller

Ed(s): R. Ryan & D. Toft

Event: 5th Ovarian Workshops at Laramie, Wyoming

Source: NC State University Libraries
Added: October 23, 2020

1984 journal article

Control of Corpus Luteum Function in the Pregnant Rabbit: Role of the Placenta (“Placental Luteotropin”) in Regulating Responsiveness of Corpora Lutea to Estrogen

Biology of Reproduction, 31(1), 16–24.

By: J. Gadsby* & P. Landis Keyes*

MeSH headings : Animals; Corpus Luteum / anatomy & histology; Corpus Luteum / drug effects; Corpus Luteum / physiology; Estradiol / blood; Estrogens / pharmacology; Female; Hysterectomy; Organ Size; Placenta / physiology; Progesterone / blood; Rabbits
TL;DR: Pregnant rabbits were assigned to the following groups and estrogen was administered via an estradiol-filled Silastic implant which was placed s.c. before (Day 20, Group C) or after (Day 22, Group D) hysterectomy, whichever came first. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 5, 2020

1984 chapter

New Perspectives on the Endocrine Regulation of the Rabbit Corpus Luteum

In Hormonal Control of the Hypothalamo-Pituitary-Gonadal Axis (pp. 273–288).

By: P. Keyes*, K. Yuh*, C. Bill* & J. Gadsby*

TL;DR: In many species a luteotrophic hormone has been identified which maintains the morphological and functional integrity of the corpus luteum, and this action, at least in sheep, is directly upon steroidogenic luteal cells. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 5, 2020

1983 journal article

Control of Corpus Luteum Function in the Pregnant Rabbit: Role of Estrogen and Lack of a Direct Luteotropic Role of the Placenta

Endocrinology, 113(6), 2255–2262.

By: J. Gadsby*, P. Keyes* & C. Bill*

MeSH headings : Animals; Chorionic Gonadotropin / pharmacology; Corpus Luteum / drug effects; Corpus Luteum / physiology; Estradiol / pharmacology; Estrogens / physiology; Female; Luteolysis; Medroxyprogesterone / analogs & derivatives; Medroxyprogesterone / pharmacology; Medroxyprogesterone Acetate; Ovulation; Placenta / physiology; Pregnancy; Pregnancy, Animal; Progesterone / blood; Rabbits
TL;DR: Results provide further evidence that estrogen is essential for normal luteal function in the pregnant rabbit and that the rabbit placenta maintained by the progestagen MPA has no direct luteotropic activity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 5, 2020

1983 chapter

EMBRYONIC STEROID SYNTHESIS AND LUTEAL OXYTOCIN PRODUCTION: CONTROLLING MECHANISMS FOR THE MATERNAL RECOGNITION OF PREGNANCY

In Hormonal Steroids (pp. 973–978).

By: A. Flint, R. Burton, J. Gadsby*, R. Heap & E. Sheldrick

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 5, 2020

1983 chapter

The Corpus Luteum

In R. Greep (Ed.), Reproductive Physiology IV (pp. 59–97). Baltimore, MD: University Park Press.

By: P. Keyes, J. Gadsby, K. Yuh & C. Bill

Ed(s): R. Greep

Source: NC State University Libraries
Added: October 23, 2020

1982 chapter

Steroid Hormones in Blastocyst Tissue, Uterine Flushings, and Endometrium of Pig, Sheep, and Cow

In Proteins and Steroids in Early Pregnancy (pp. 173–182).

By: J. Gadsby*

TL;DR: Pig blastocyst tissue as early as the 12th day of gestation displays a marked capacity to synthesize oestrogens in vitro, suggesting the presence of these pathways of oestrogen synthesis shown in Fig. 1. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 5, 2020

1982 chapter

The Synthesis of Steroids and Proteins in the Pig Blastocyst

In Proteins and Steroids in Early Pregnancy (pp. 157–171).

By: R. Heap*, J. Gadsby*, C. Rice* & J. Perry*

Sources: Crossref, NC State University Libraries
Added: February 5, 2020

1981 chapter

Embryonic signals and maternal recognition

In S. R. Glasser & D. W. Bullock (Eds.), Cellular and Molecular aspects of Implantation (pp. 311–326). New York: Plenum Press.

By: R. Heap, A. Flint & J. Gadsby

Ed(s): S. Glasser & D. Bullock

Source: NC State University Libraries
Added: October 23, 2020

1981 journal article

Oestrogen production in early pregnancy

Journal of Endocrinology Supplement, 89, 77–94.

By: R. Heap, A. Flint, P. Hartmann, J. Gadsby, L. Staples, N. Ackland, M. Hamon

Source: NC State University Libraries
Added: October 23, 2020

1980 conference paper

Blastocyst steroids and implantation

In I. A. Cumming, J. W. Funder, & F. A. O. Mendelsohn (Eds.), Endocrinology 1980: proceedings of the VI International Congress of Endocrinology, Melbourne, Australia, February 10-16, 1980 (pp. 79–82). Melbourne, Australia: Australian Academy of Science.

By: R. Heap, A. Flint, J. Gadsby & F. Maule Walker

Ed(s): I. Cumming, J. Funder & F. Mendelsohn

Event: at Melbourne, Australia on February 10-16, 1980

Source: NC State University Libraries
Added: October 23, 2020

1980 journal article

Oestrogen production by blastocyst and early embryonic tissue of various species

Reproduction, 60(2), 409–417.

By: J. Gadsby*, R. Heap* & R. Burton*

MeSH headings : Androstenedione / metabolism; Animals; Aromatase / metabolism; Blastocyst / metabolism; Cats; Cattle; Deer; Dehydroepiandrosterone / metabolism; Embryo Implantation; Estrogens / biosynthesis; Female; Ferrets; Pregnancy; Rabbits; Rodentia; Sheep; Swine; Trophoblasts / enzymology
TL;DR: High aromatase activity in preimplantation trophoblast of pigs was associated with the maternal recognition of pregnancy and the occurrence of superficial implantation in this species. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 5, 2020

1979 chapter

Blastocyst oestrogen synthesis and the maternal recognition of pregnancy

In J. Whelan (Ed.), Maternal Recognition of Pregnancy (pp. 209–228). Amsterdam: Excerpta Medica.

By: A. Flint, R. Burton, J. Gadsby, P. Saunders & R. Heap

Ed(s): J. Whelan

Source: NC State University Libraries
Added: October 23, 2020

1979 conference paper

Blastocyst steroids: their synthesis and action

In A. Klopper, L. Lerner, H. J. van der Molen, & F. Sciarra (Eds.), Research on steroids (Vol. 8, pp. 3–10). London, U.K: Academic Press.

By: A. Flint, J. Gadsby & R. Heap

Ed(s): A. Klopper, L. Lerner, H. van der Molen & F. Sciarra

Source: NC State University Libraries
Added: October 23, 2020

1979 journal article

Hormones, the early embryo and the uterine environment

Reproduction, 55(1), 267–275.

By: R. Heap*, A. Flint*, J. Gadsby* & C. Rice*

MeSH headings : Animals; Blastocyst / growth & development; Blastocyst / metabolism; Blastocyst / physiology; Embryo Implantation; Embryo, Mammalian / metabolism; Embryo, Mammalian / physiology; Endometrium / physiology; Estrogens / biosynthesis; Estrogens / physiology; Female; Humans; Swine; Uterus / physiology
TL;DR: The nature of the interaction between the endometrium and the blastocyst is considered and where interception may inhibit maternal or embryonic signals which are indispensible for implantation and the establishment of pregnancy is indicated. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 5, 2020

1979 journal article

ROLE OF EMBRYONIC SIGNALS IN THE ESTABLISHMENT OF PREGNANCY

British Medical Bulletin, 35(2), 129–135.

By: R. Heap*, A. Flint* & J. Gadsby*

MeSH headings : Animals; Cattle; Chorionic Gonadotropin / physiology; Corpus Luteum Maintenance; Embryo, Mammalian / immunology; Embryo, Mammalian / metabolism; Embryo, Mammalian / physiology; Embryonic Development; Female; Fetal Death; Guinea Pigs; Humans; Maternal-Fetal Exchange; Mice; Pregnancy; Progesterone / blood; Progesterone / physiology; Rabbits; Rats; Sheep; Swine; Uterus / immunology; Uterus / physiology
Sources: Crossref, NC State University Libraries
Added: February 5, 2020

1978 chapter

Blastocyst steroids: their synthesis and actions.

In F. Du Mesnil du Buisson, A. Psychoyos, & K. Thomas (Eds.), L'implantation de l'oeuf : colloque de la Société nationale pour l'étude de la stérilité et de la fécondité (pp. 177–179). Paris, France: Thomas. Masson.

By: A. Flint, J. Gadsby & R. Heap

Ed(s): F. Du Mesnil du Buisson, A. Psychoyos & K. Thomas

Source: NC State University Libraries
Added: October 23, 2020

1978 chapter

Steroid hormones and their synthesis in the early embryo

In E. C. H. Spilman & J. W. Wilks (Eds.), Novel Aspects of Reproductive Physiology (pp. 263–285). New York: SP Medical and Scientific Books.

By: J. Gadsby & R. Heap

Ed(s): E. Spilman & J. Wilks

Source: NC State University Libraries
Added: October 23, 2020

1977 chapter

Blastocyst steroidogenesis and embryo-maternal interactions in the establishment of pregnancy

In J. H. Calaby & C. H. Tyndale-Biscoe (Eds.), Reproduction and Evolution : proceedings of the Fourth Symposium on Comparative Biology of Reproduction, held in Canberra, December, 1976 (pp. 341–347). Canberra: Australian Academy of Sciences.

By: R. Heap, J. Perry, R. Burton, J. Gadsby, C. Wyatt & G. Jenkin

Ed(s): J. Calaby & C. Tyndale-Biscoe

Source: NC State University Libraries
Added: October 23, 2020

1977 journal article

Endocrine Activities and Protein Synthesis in the Early Blastocyst

Biochemical Society Transactions, 5(2), 457–458.

By: R. Heap*, J. Perry*, J. Gadsby*, R. Burton* & C. Wyatt*

MeSH headings : Animals; Blastocyst / metabolism; Estradiol / biosynthesis; Estrogens / biosynthesis; Estrone / biosynthesis; Female; Pregnancy; Pregnenolone / metabolism; Progesterone / metabolism; Protein Biosynthesis; Sulfatases / metabolism; Sulfurtransferases / metabolism; Swine; Uterus / physiology
Sources: Crossref, NC State University Libraries
Added: February 5, 2020

1976 journal article

Endocrinology of the blastocyst and its role in the establishment of pregnancy

Journal of Reproduction and Fertility, Suppl. 25, 85–104.

By: J. Perry, R. Heap, R. Burton & J. Gadsby

Source: NC State University Libraries
Added: October 23, 2020

1976 journal article

Pregnancy Diagnosis in the Cow from Milk Progesterone Concentration

British Veterinary Journal, 132(5), 445–464.

By: R. Heap*, R. Holdsworth*, J. Gadsby*, J. Laing* & D. Walters

MeSH headings : Animals; Cattle / physiology; Female; Milk / analysis; Pregnancy; Pregnancy Tests / veterinary; Progesterone / analysis
TL;DR: Milk progesterone concentrations were significantly higher in pregnant cows compared with those in non-pregnant cows at 21, 24, 28, 42 and 60 days after insemination, and the concentration was greater in full milk taken from full milk collected at afternoon milking than in first milk taken at morning milking. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 5, 2020

1975 journal article

Endocrine Activities of the Blastocyst and Early Embryonic Tissue in the Pig

Biochemical Society Transactions, 3(6), 1183–1188.

By: R. Heap*, J. Perry*, E. Gadsby* & R. Burton*

TL;DR: The mechanism(s) by which steroid hormones influence uterine DNA synthesis is slowly succumbing to investigation, however, the nature of the changes in control of DNA synthesis associated with such complications as the onset of pregnancy or the development of uterine carcinoma still presents a considerable challenge. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 5, 2020

1972 journal article

Diagnosis of pregnancy and of the number of foetuses in sheep from plasma progesterone concentrations

Veterinary Record, 90(12), 339–342.

By: J. Gadsby*, R. Heap, D. Powell & D. Walters

MeSH headings : Animals; Female; Pregnancy; Pregnancy Tests / veterinary; Pregnancy, Multiple; Progesterone / blood; Sheep / physiology; Statistics as Topic; Time Factors; Ultrasonography
Sources: Crossref, NC State University Libraries
Added: February 5, 2020

Employment

Updated: January 11th, 2020 15:43

1985 - present

College of Veterinary Medicine, North Carolina State University NC, NC, US
Professor of Physiology (Reproductive Endocrinology) Molecular Biomedical Sciences,

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