@article{wang_rivenbark_gong_wright_phillips_2021, title={Application of Edible Montmorillonite Clays for the Adsorption and Detoxification of Microcystin}, volume={4}, ISSN={["2576-6422"]}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-85115268354&partnerID=MN8TOARS}, DOI={10.1021/acsabm.1c00779}, abstractNote={Exposure to microcystins (MCs) in humans and animals commonly occurs through the consumption of drinking water and food contaminated with cyanobacteria. Although studies have focused on developing water filtration treatments for MCs using activated carbon, dietary sorbents to reduce the bioavailability of MCs from the stomach and intestines have not been reported. To address this need, edible calcium and sodium montmorillonite clays were characterized for their ability to bind MC containing leucine and arginine (MC-LR) under conditions simulating the gastrointestinal tract and compared with a medical-grade activated carbon. Results of in vitro adsorption isotherms and thermodynamics showed that binding plots for MC-LR on montmorillonites fit the Langmuir model with high binding capacity, affinity, Gibbs free energy, and enthalpy. The in silico results from molecular modeling predicted that the major binding mechanisms involved electrostatics and hydrogen bonds, and that interlayers were important binding sites. The safety and detoxification efficacy of the sorbents against MC-LR were validated in a battery of living organisms, including Hydra vulgaris, Lemna minor, and Caenorhabditis elegans. The inclusion of 0.05% and 0.1% montmorillonite clays in hydra media significantly reduced MC-LR toxicity and protected hydra by 60-80%, whereas only slight protection was shown with the heat-collapsed clay. In the Lemna minor assay, montmorillonites significantly enhanced the growth of lemna, as supported by the increase in frond number, surface area, chlorophyll content, and growth rate, as well as the decrease in inhibition rate. Similar results were shown in the C. elegans assay, where montmorillonite clays reduced MC-LR effects on body length and brood size. All 3 bioassays confirmed dose-dependent protection from MC-LR, validated the in vitro and in silico findings, and suggested that edible montmorillonites are safe and efficacious binders for MC-LR. Moreover, their inclusion in diets during algal blooming seasons could protect vulnerable populations of humans and animals.}, number={9}, journal={ACS APPLIED BIO MATERIALS}, author={Wang, Meichen and Rivenbark, Kelly and Gong, Joonho and Wright, Fred A. and Phillips, Timothy D.}, year={2021}, month={Sep}, pages={7254–7265} }
 @article{gong_kim_2017, title={RHSBoost: Improving classification performance in imbalance data}, volume={111}, ISSN={["1872-7352"]}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-85012075581&partnerID=MN8TOARS}, DOI={10.1016/j.csda.2017.01.005}, abstractNote={Imbalance data are defined as a dataset whose proportion of classes is severely skewed. Classification performance of existing models tends to deteriorate due to class distribution imbalance. In addition, over-representation by majority classes prevents a classifier from paying attention to minority classes, which are generally more interesting. An effective ensemble classification method called RHSBoost has been proposed to address the imbalance classification problem. This classification rule uses random undersampling and ROSE sampling under a boosting scheme. According to the experimental results, RHSBoost appears to be an attractive classification model for imbalance data.}, journal={COMPUTATIONAL STATISTICS & DATA ANALYSIS}, author={Gong, Joonho and Kim, Hyunjoong}, year={2017}, month={Jul}, pages={1–13} }