Works (70)

Updated: February 28th, 2024 05:02

2024 journal article

Expanded library of novel 2,3-pyrrolidinedione analogues exhibit anti-biofilm activity

Bioorganic & Medicinal Chemistry Letters.

By: M. Nie n, M. Valdes-Pena n, B. Frohock  n, E. Smits n, J. Daiker n, J. Gilbertie  n, L. Schnabel  n, J. Pierce n 

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: January 7, 2024

2024 article

Total Synthesis and Microbiological Evaluation of Leopolic Acid A and Analogues

Breunig, J. L., Valdes-Pena, M. A., Ratchford, A. W., & Pierce, J. G. (2024, January 12). ACS BIO & MED CHEM AU, Vol. 1.

By: J. Breunig n, M. Valdes-Pena n, A. Ratchford n & J. Pierce n 

co-author countries: United States of America 🇺🇸
author keywords: antibiotics; antibiofilm; naturalproducts; multicomponent reactions; heterocycles
Sources: ORCID, Web Of Science
Added: January 13, 2024

2023 journal article

Photoredox Catalyzed C(sp3)-C(sp3) Coupling of α-Bromoesters and Triethylamine

JOURNAL OF ORGANIC CHEMISTRY, 89(1), 810–814.

By: A. Guerra n & J. Pierce n 

co-author countries: United States of America 🇺🇸
Sources: ORCID, Web Of Science
Added: December 22, 2023

2023 article

Using Stem Mini-Organs to Find New Cures

Piedrahita, J., & Pierce, J. (2023, August 4).

By: J. Piedrahita  n & J. Pierce n 

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: August 11, 2023

2022 article

Chemistry Drives Solutions to Our Planet’s Largest Problems: COVID-19 and Beyond

Pierce, J. (2022, June 22).

By: J. Pierce n 

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: August 17, 2022

2022 journal article

Restoring Carboxylates on Highly Modified Alginates Improves Gelation, Tissue Retention and Systemic Capture

ACTA BIOMATERIALIA, 138, 208–217.

By: C. Moody n, A. Brown n, N. Massaro n, A. Patel n, P. Agarwalla n, A. Simpson  n, A. Brown n, H. Zheng n , J. Pierce n , Y. Brudno n 

co-author countries: United States of America 🇺🇸
author keywords: Alginate; Click chemistry; Bioconjugation; Ionic cross-linking; Drug capture
Sources: ORCID, Web Of Science
Added: October 31, 2021

2022 article

Synthesis provides insight into a traditional medicine

Onuska, N. P. R., & Pierce, J. G. (2022, June 30). NATURE, Vol. 606, pp. 869–870.

By: N. Onuska n & J. Pierce n 

co-author countries: United States of America 🇺🇸
author keywords: Chemical biology; Organic chemistry; Chemistry; Synthesis
MeSH headings : Chemistry Techniques, Synthetic; Medicine, Traditional; Molecular Targeted Therapy / trends
Sources: Web Of Science, ORCID
Added: July 11, 2022

2022 journal article

Tissue-reactive drugs enable materials-free local depots

JOURNAL OF CONTROLLED RELEASE, 343, 142–151.

By: S. Pandit n, S. Palvai n, N. Massaro n, J. Pierce n  & Y. Brudno n 

co-author countries: United States of America 🇺🇸
author keywords: Sustained release; Materials-free delivery; Paclitaxel; Pancreatic cancer; Extracellular matrix; N-hydroxysuccinimide ester
MeSH headings : Animals; Cell Line, Tumor; Drug Delivery Systems; Drug Liberation; Hydrogels; Mice; Paclitaxel; Pancreatic Neoplasms / drug therapy
Sources: Web Of Science, ORCID
Added: May 2, 2022

2022 article

Total Synthesis of Bipolamine I

Pierce, J. G., & Qiu, X. (2022, July 5). JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol. 7.

By: J. Pierce n  & X. Qiu n 

co-author countries: United States of America 🇺🇸
MeSH headings : Alkaloids; Biological Products; Polymers; Pyrroles; Stereoisomerism
Sources: ORCID, Web Of Science
Added: July 6, 2022

2021 journal article

Design, synthesis, and evaluation of substrate - analogue inhibitors of Trypanosoma cruzi ribose 5-phosphate isomerase type B

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 32.

By: S. Natalia Gonzalez*, J. Mills  n, D. Maugeri*, C. Olaya n, B. Laguera *, J. Enders n , J. Sherman, A. Rodriguez ...

co-author countries: Argentina 🇦🇷 United States of America 🇺🇸
author keywords: Neglected tropical diseases; Chagas' disease; Trypanosoma cruzi; Amastigote; Trypomastigote; Isomerase; Substrate-analogue inhibitors; Competitive inhibition; Trypsin digestion LC-MS/MS
MeSH headings : 3T3 Cells; Aldose-Ketose Isomerases / antagonists & inhibitors; Aldose-Ketose Isomerases / metabolism; Animals; Binding Sites; Catalytic Domain; Drug Design; Enzyme Inhibitors / chemistry; Enzyme Inhibitors / metabolism; Enzyme Inhibitors / pharmacology; Kinetics; Mice; Molecular Dynamics Simulation; Protozoan Proteins / antagonists & inhibitors; Protozoan Proteins / metabolism; Substrate Specificity; Trypanocidal Agents / chemical synthesis; Trypanocidal Agents / metabolism; Trypanocidal Agents / pharmacology; Trypanosoma cruzi / drug effects; Trypanosoma cruzi / enzymology
Sources: ORCID, Web Of Science
Added: December 15, 2020

2021 review

Leveraging Marine Natural Products as a Platform to Tackle Bacterial Resistance and Persistence

[Review of ]. ACCOUNTS OF CHEMICAL RESEARCH, 54(8), 1866–1877.

By: M. Valdes-Pena n, N. Massaro n, Y. Lin n & J. Pierce n 

co-author countries: United States of America 🇺🇸
MeSH headings : Alkaloids / chemical synthesis; Alkaloids / pharmacology; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Biofilms / drug effects; Biological Products / chemical synthesis; Biological Products / chemistry; Biological Products / pharmacology; Drug Resistance, Multiple, Bacterial / drug effects; Guanidine / analogs & derivatives; Guanidine / chemical synthesis; Guanidine / pharmacology; Guanidines / chemical synthesis; Guanidines / pharmacology; Microbial Sensitivity Tests; Oxazolidinones / chemical synthesis; Oxazolidinones / pharmacology; Staphylococcus aureus / drug effects; Staphylococcus aureus / physiology; Stereoisomerism; Structure-Activity Relationship
Sources: ORCID, Web Of Science
Added: March 19, 2021

2021 journal article

Rapid synthesis of the core scaffold of crinane and haemanthamine through a multi-component approach

TETRAHEDRON LETTERS, 75.

By: N. Massaro n & J. Pierce n 

co-author countries: United States of America 🇺🇸
author keywords: Amaryllidaceae alkaloids; Heterocycles; Multicomponent; Natural products; Total synthesis
Sources: ORCID, Web Of Science
Added: May 25, 2021

2021 journal article

Stereoselective Synthesis of the Spirocyclic gamma-Lactam Core of the Ansalactams

ORGANIC LETTERS, 23(24), 9559–9562.

By: Z. Liang n, Y. Lin n & J. Pierce n 

co-author countries: United States of America 🇺🇸
MeSH headings : Spiro Compounds
Sources: ORCID, Web Of Science
Added: December 1, 2021

2020 chapter

1,4-Oxazines and their Benzo Derivatives

In Comprehensive Heterocyclic Chemistry IV.

By: Y. Lin, C. Martinez-Brokaw & J. Pierce 

co-author countries: United Kingdom of Great Britain and Northern Ireland 🇬🇧
Sources: Crossref, ORCID
Added: December 24, 2020

2020 journal article

Concise Synthesis and Antimicrobial Evaluation of the Guanidinium Alkaloid Batzelladine D: Development of a Stereodivergent Strategy

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 142(21), 9850–9857.

By: Y. Lin n, A. Ribaucourt n, Y. Moazami n & J. Pierce n 

co-author countries: United States of America 🇺🇸
MeSH headings : Alkaloids / chemical synthesis; Alkaloids / chemistry; Alkaloids / pharmacology; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Microbial Sensitivity Tests; Molecular Conformation; Pyrimidines / chemical synthesis; Pyrimidines / chemistry; Pyrimidines / pharmacology; Staphylococcus aureus / drug effects; Stereoisomerism
Sources: Web Of Science, ORCID
Added: June 22, 2020

2020 journal article

Front Cover: 5‐Benzylidene‐4‐Oxazolidinones Are Synergistic with Antibiotics for the Treatment of Staphylococcus aureus Biofilms (ChemBioChem 7/2020)

ChemBioChem.

By: B. Frohock  n, J. Gilbertie  n, J. Daiker n, L. Schnabel  n & J. Pierce n 

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: December 15, 2020

2020 journal article

Genetic Determinants of Salmonella Resistance to the Biofilm-Inhibitory Effects of a Synthetic 4-Oxazolidinone Analog

Applied and Environmental Microbiology, 86(20).

By: K. Griewisch n, J. Pierce n  & J. Elfenbein n

co-author countries: United States of America 🇺🇸

Ed(s): M. Kivisaar

author keywords: Salmonella; antimicrobial resistance; biofilm; genetics
MeSH headings : Anti-Bacterial Agents / pharmacology; Biofilms / drug effects; Drug Resistance, Bacterial / genetics; Oxazolidinones / pharmacology; Salmonella typhimurium / drug effects; Salmonella typhimurium / genetics
Sources: ORCID, Crossref, Web Of Science
Added: November 16, 2020

2020 journal article

In Vitro Evaluation of a Novel Synthetic Bilirubin Analog as an Antioxidant and Cytoprotective Agent for Pancreatic Islet Transplantation

Cell Transplantation, 29, 096368972090641.

By: E. Luckring n, P. Parker n, H. Hani*, M. Grace n , M. Lila n, J. Pierce n , C. Adin *

co-author countries: United States of America 🇺🇸

Contributors: E. Luckring n, P. Parker n, H. Hani*, M. Grace n , M. Lila n, J. Pierce n , C. Adin *

MeSH headings : Animals; Antioxidants / chemical synthesis; Antioxidants / chemistry; Bilirubin / analogs & derivatives; Bilirubin / chemical synthesis; Bilirubin / chemistry; Cell Survival / physiology; Fluorescence Recovery After Photobleaching; Islets of Langerhans Transplantation / methods; Molecular Structure; Swine
Source: ORCID
Added: July 9, 2020

2020 journal article

Stereocontrolled Synthesis of (±)-Melokhanine E via an Intramolecular Formal [3 + 2] Cycloaddition

Organic Letters, 22(2), 714–717.

By: A. Cholewczynski  n, P. Williams n & J. Pierce n 

co-author countries: United States of America 🇺🇸
MeSH headings : Cycloaddition Reaction; Cyclopropanes / chemistry; Imines / chemistry; Molecular Structure; Secologanin Tryptamine Alkaloids / chemical synthesis; Secologanin Tryptamine Alkaloids / chemistry; Stereoisomerism
Source: ORCID
Added: December 15, 2020

2020 journal article

Stereoselective, Multicomponent Approach to Quaternary Substituted Hydroindole Scaffolds

ORGANIC LETTERS, 22(13), 5079–5084.

By: N. Massaro n & J. Pierce n 

co-author countries: United States of America 🇺🇸
MeSH headings : Amaryllidaceae Alkaloids / chemistry; Indoles / chemical synthesis; Indoles / chemistry; Stereoisomerism
Sources: Web Of Science, ORCID
Added: August 3, 2020

2019 article

5-Benzylidene-4-Oxazolidinones Are Synergistic with Antibiotics for the Treatment of Staphylococcus aureus Biofilms

CHEMBIOCHEM, Vol. 12.

By: B. Frohock n, J. Gilbertie n, J. Daiker n, L. Schnabel n & J. Pierce n 

co-author countries: United States of America 🇺🇸
MeSH headings : Acinetobacter baumannii / drug effects; Anti-Bacterial Agents / pharmacology; Benzylidene Compounds / pharmacology; Biofilms / drug effects; Drug Synergism; Methicillin-Resistant Staphylococcus aureus / drug effects; Microbial Sensitivity Tests; Oxazolidinones / pharmacology; Staphylococcus aureus / physiology; Structure-Activity Relationship
Sources: ORCID, Web Of Science
Added: January 13, 2020

2019 journal article

5-Benzylidene-4-Oxazolidinones are Synergistic with Antibiotics for the Treatment of Staphylococcus Aureus Biofilms

[Preprint]. 9.

By: B. Frohock  n, J. Gilbertie  n, J. Daiker n, L. Schnabel  n & J. Pierce n 

co-author countries: United States of America 🇺🇸
Sources: Crossref, ORCID
Added: December 22, 2020

2019 journal article

Accidental intoxications in toddlers: lack of cross-reactivity of vilazodone and its urinary metabolite M17 with drug of abuse screening immunoassays

BMC CLINICAL PATHOLOGY, 19.

By: C. Martinez-Brokaw n, J. Radke *, J. Pierce n , A. Ehlers*, S. Ekins *, K. Wood *, J. Maakestad*, J. Rymer*, K. Tamama *, M. Krasowski *

co-author countries: United States of America 🇺🇸
author keywords: Amphetamines; False positive reactions; Immunoassay; Similarity; Toxicology
Sources: Web Of Science, ORCID
Added: March 4, 2019

2019 article

Concise Synthesis and Antimicrobial Evaluation of the Guanidinium Alkaloid Batzelladine D

Pierce, J., & Lin, Y.-C. (2019, October 3). (Vol. 10). Vol. 10.

By: J. Pierce n  & Y. Lin n

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: October 22, 2021

2019 article

Concise Synthesis and Antimicrobial Evaluation of the Guanidinium Alkaloid Batzelladine D

Lin, Y.-C., Ribaucourt, A., Moazami, Y., & Pierce, J. (2019, October 4).

By: Y. Lin, A. Ribaucourt, Y. Moazami & J. Pierce n 

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: October 22, 2021

2019 journal article

Expanded Structure-Activity Studies of Lipoxazolidinone Antibiotics

ACS MEDICINAL CHEMISTRY LETTERS, 10(3), 374-+.

By: K. Robinson n, J. Mills  n & J. Pierce n 

co-author countries: United States of America 🇺🇸
author keywords: Oxazolidinones; antibiotics; MRSA; heterocycles
Sources: Web Of Science, ORCID
Added: April 2, 2019

2019 journal article

Stereocontrolled Synthesis of Melokhanine E via an Intramolecular Formal [3+2] Cycloaddition

[Preprint]. 10.

By: J. Pierce n , A. Cholewczynski & P. Williams

co-author countries: United States of America 🇺🇸
Sources: Crossref, ORCID
Added: December 22, 2020

2018 journal article

3-Hydroxy-1,5-dihydro-2H-pyrrol-2-ones as novel antibacterial scaffolds against methicillin-resistant Staphylococcus aureus

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 28(16), 2732–2735.

By: A. Cusumano  n & J. Pierce n 

co-author countries: United States of America 🇺🇸
author keywords: Natural products; Antibiotics; Heterocycles; Cyclization; Medicinal chemistry
MeSH headings : Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Dose-Response Relationship, Drug; Methicillin Resistance / drug effects; Methicillin-Resistant Staphylococcus aureus / drug effects; Microbial Sensitivity Tests; Molecular Structure; Pyrroles / chemical synthesis; Pyrroles / chemistry; Pyrroles / pharmacology; Staphylococcus epidermidis / drug effects; Structure-Activity Relationship
Sources: Web Of Science, ORCID
Added: October 19, 2018

2018 journal article

Coupling of thioamides with 4-bromocrotonate esters and subsequent conjugate addition for the rapid one-pot synthesis of functionalized thiazolines

Tetrahedron Letters, 59(3), 277–279.

By: P. Parker n, Y. Ge n & J. Pierce n 

co-author countries: United States of America 🇺🇸
author keywords: Heterocycle; Natural products; Medicinal chemistry; Alkylation; Thiazoline
Sources: Crossref, ORCID
Added: February 24, 2020

2018 journal article

Mast cell degranulation and calcium influx are inhibited by an Echinacea purpurea extract and the alkylamide dodeca-2E,4E-dienoic acid isobutylamide

Journal of Ethnopharmacology, 212, 166–174.

By: T. Gulledge n, N. Collette n, E. Mackey *, S. Johnstone n, Y. Moazami n, D. Todd*, A. Moeser *, J. Pierce n , N. Cech *, S. Laster n

co-author countries: United States of America 🇺🇸
author keywords: Alkylamide; Echinacea purpurea; Allergies; Inflammation; Mast cell
MeSH headings : Amides / chemistry; Amides / pharmacology; Animals; Calcium / metabolism; Cell Line; Dinoprostone / genetics; Dinoprostone / metabolism; Echinacea / chemistry; Female; Gene Expression Regulation / drug effects; Humans; Male; Mast Cells / drug effects; Mice; Plant Extracts / chemistry; Plant Extracts / pharmacology; Rats; Tumor Necrosis Factor-alpha / genetics; Tumor Necrosis Factor-alpha / metabolism
Sources: Crossref, ORCID
Added: February 21, 2020

2018 journal article

Synthesis and Biological Evaluation of the Antimicrobial Natural Product Lipoxazolidinone A

Angewandte Chemie, 130(28), 8818–8822.

By: J. Mills  n, K. Robinson n, T. Zehnder n & J. Pierce n 

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: December 15, 2020

2018 article

Synthesis and Biological Evaluation of the Antimicrobial Natural Product Lipoxazolidinone A

Mills, J. J., Robinson, K. R., Zehnder, T. E., & Pierce, J. G. (2018, April 9).

By: J. Mills, K. Robinson, T. Zehnder & J. Pierce n 

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: October 21, 2021

2018 journal article

Synthesis and Biological Evaluation of the Antimicrobial Natural Product Lipoxazolidinone A

Angewandte Chemie International Edition, 57(28), 8682–8686.

By: J. Mills  n, K. Robinson n, T. Zehnder n & J. Pierce n 

co-author countries: United States of America 🇺🇸
author keywords: antibiotics; cyclization; heterocycles; medicinal chemistry; natural products
MeSH headings : Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Biological Products / chemical synthesis; Biological Products / chemistry; Biological Products / pharmacology; Methicillin-Resistant Staphylococcus aureus / drug effects; Microbial Sensitivity Tests; Molecular Structure; Oxazolidinones / chemical synthesis; Oxazolidinones / chemistry; Oxazolidinones / pharmacology; Structure-Activity Relationship
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2018 journal article

Synthesis of Quaternary-Substituted Thiazolines via Halocyclization of S-Allyl Thioimidate Salts

The Journal of Organic Chemistry, 83(1), 12–22.

By: P. Parker n, B. Lemercier n & J. Pierce n 

co-author countries: United States of America 🇺🇸
Sources: Crossref, ORCID
Added: December 11, 2020

2017 journal article

5-Benzylidene-4-oxazolidinones potently inhibit biofilm formation in Methicillin-resistant Staphylococcus aureus

Chemical Communications, 53(53), 7353–7356.

By: G. Edwards n, N. Shymanska n & J. Pierce n 

co-author countries: United States of America 🇺🇸
MeSH headings : Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Benzylidene Compounds / chemistry; Benzylidene Compounds / pharmacology; Biofilms / drug effects; Dose-Response Relationship, Drug; Methicillin-Resistant Staphylococcus aureus / drug effects; Microbial Sensitivity Tests; Molecular Structure; Oxazolidinones / chemistry; Oxazolidinones / pharmacology; Structure-Activity Relationship
Sources: Crossref, ORCID
Added: February 24, 2020

2017 journal article

Direct Access to Highly Functionalized Heterocycles through the Condensation of Cyclic Imines and alpha-Oxoesters

JOURNAL OF ORGANIC CHEMISTRY, 82(24), 13714–13721.

By: A. Cusumano  n, M. Boudreau  n & J. Pierce n 

co-author countries: United States of America 🇺🇸
MeSH headings : Cyclization; Heterocyclic Compounds / chemistry; Imines / chemistry; Molecular Structure
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

How Cancer Cells Become Resistant to Cationic Lytic Peptides: It’s the Sugar!

Cell Chemical Biology, 24(2), 121–122.

By: J. Pierce n 

co-author countries: United States of America 🇺🇸
MeSH headings : Cell Line, Tumor; Cell Membrane; Peptides; Polysaccharides; Sugars
Sources: Crossref, ORCID
Added: December 11, 2020

2017 journal article

Stereoselective Synthesis of Quaternary Pyrrolidine-2,3-diones and beta-Amino Acids

ORGANIC LETTERS, 19(11), 2961–2964.

By: N. Shymanska n & J. Pierce n 

co-author countries: United States of America 🇺🇸
MeSH headings : Amino Acids; Cyclization; Molecular Structure; Pyrrolidines / chemistry; Stereoisomerism
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

Structure, synthesis and biological properties of the pentacyclic guanidinium alkaloids

Bioorganic & Medicinal Chemistry, 25(11), 2817–2824.

By: Y. Shi  n, Y. Moazami n & J. Pierce n 

co-author countries: United States of America 🇺🇸
author keywords: Guanidinium alkaloids; Marine natural products; Chemical probe; Structure-activity relationship; Mechanism of action
MeSH headings : Alkaloids / chemical synthesis; Alkaloids / chemistry; Alkaloids / pharmacology; Animals; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Antifungal Agents / chemical synthesis; Antifungal Agents / chemistry; Antifungal Agents / pharmacology; Antineoplastic Agents / chemical synthesis; Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; Antiprotozoal Agents / chemical synthesis; Antiprotozoal Agents / chemistry; Antiprotozoal Agents / pharmacology; Antiviral Agents / chemical synthesis; Antiviral Agents / chemistry; Antiviral Agents / pharmacology; Guanidine / chemical synthesis; Guanidine / chemistry; Guanidine / pharmacology; Humans; Molecular Structure; Structure-Activity Relationship
Sources: Crossref, ORCID
Added: February 24, 2020

2016 journal article

Examining ubiquitinated peptide enrichment efficiency through an epitope labeled protein

ANALYTICAL BIOCHEMISTRY, 512, 114–119.

By: J. Parker  n, Y. Oh n, Y. Moazami n, J. Pierce n , P. Loziuk n, R. Dean n , D. Muddiman n 

co-author countries: United States of America 🇺🇸
author keywords: Ubiquitination; Gly-Gly enrichment; Enrichment efficiency
MeSH headings : Antibodies, Monoclonal, Murine-Derived / chemistry; Epitopes / chemistry; Muramidase / chemistry; Ubiquitinated Proteins / chemistry; Ubiquitination
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

Stereocontrolled Synthesis of (+)-Plagiogyrin A

Organic Letters, 18(20), 5308–5311.

By: Y. Shi  n & J. Pierce n 

co-author countries: United States of America 🇺🇸
Sources: Crossref, ORCID
Added: February 24, 2020

2016 journal article

Synthesis of 1,2,4-Oxadiazoles via DDQ-Mediated Oxidative Cyclization of Amidoximes

Synthesis, 48(12), 1902–1909.

By: J. Pierce n  & P. Parker n

co-author countries: United States of America 🇺🇸
author keywords: oxidation; cyclization; heterocycles; radicals; medicinal chemistry
Sources: Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2016 journal article

Thiohydroximic acids: Versatile reagents for organic synthesis

Synlett, 27(2), 181–189.

By: B. Lemercier & J. Pierce 

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Marine natural products synthesis as a driving force for chemical and biological discovery

Planta Medica, 81(11).

By: J. Pierce n , N. Shymanska n & G. Edwards n

co-author countries: United States of America 🇺🇸
Sources: Crossref, ORCID
Added: February 24, 2020

2015 journal article

Rapid synthesis and antimicrobial activity of novel 4-oxazolidinone heterocycles

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 25(21), 4887–4889.

By: N. Shymanska n, I. An n, S. Guevara-Zuluaga n & J. Pierce n 

co-author countries: Puerto Rico 🇵🇷 United States of America 🇺🇸
author keywords: Antibiotic; Heterocycle; Oxazolidinone; Natural products
MeSH headings : Acinetobacter baumannii / drug effects; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Dose-Response Relationship, Drug; Microbial Sensitivity Tests; Molecular Structure; Oxazolidinones / chemical synthesis; Oxazolidinones / chemistry; Oxazolidinones / pharmacology; Staphylococcus aureus / drug effects; Structure-Activity Relationship
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

Synthesis and biological evaluation of a series of fatty acid amides from Echinacea

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 25(16), 3091–3094.

By: Y. Moazami n, T. Gulledge n, S. Laster n & J. Pierce n 

co-author countries: United States of America 🇺🇸
author keywords: Echinacea; Alkylamide; TNF-alpha; Anti-inflammatory; Cytokine
MeSH headings : Amides / chemical synthesis; Amides / chemistry; Amides / pharmacology; Animals; Cell Line; Echinacea / chemistry; Echinacea / metabolism; Fatty Acids / chemistry; Lipopolysaccharides / toxicity; Macrophages / cytology; Macrophages / drug effects; Macrophages / metabolism; Mice; Plant Extracts / chemistry; Tumor Necrosis Factor-alpha / metabolism
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

Synthesis of 1,4,2-Oxathiazoles via Oxidative Cyclization of Thiohydroximic Acids

ORGANIC LETTERS, 17(18), 4542–4545.

By: B. Lemercier n & J. Pierce n 

co-author countries: United States of America 🇺🇸
MeSH headings : Antineoplastic Agents / chemical synthesis; Antineoplastic Agents / chemistry; Catalysis; Copper / chemistry; Cyclization; Molecular Structure; Oxidation-Reduction; Oximes / chemistry; Thiazoles / chemical synthesis; Thiazoles / chemistry
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

Synthesis of 2,3-Dihydro-1,3-oxazin-4-ones via a Mild Formal [4+2] Cycloaddition of Acylketenes with Aldimines

Synthesis, 47(21), 3363–3370.

By: J. Pierce n  & Y. Moazami n

co-author countries: United States of America 🇺🇸
author keywords: cycloaddition; heterocycles; imines; transition metals; acylation
Sources: Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2015 journal article

Synthesis of the 5,6-Dihydroxymorpholin-3-one Fragment of Monanchocidin A

ORGANIC LETTERS, 17(4), 968–971.

By: Y. Shi n & J. Pierce n 

co-author countries: United States of America 🇺🇸
MeSH headings : Alkaloids / chemical synthesis; Alkaloids / chemistry; Guanidine / analogs & derivatives; Guanidine / chemical synthesis; Guanidine / chemistry; Molecular Structure; Morpholines / chemical synthesis; Morpholines / chemistry; Stereoisomerism
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

Thiohydroximic Acids: Versatile Reagents for Organic Synthesis

Synlett, 27(02), 181–189.

By: J. Pierce n  & B. Lemercier n

co-author countries: United States of America 🇺🇸
author keywords: heterocycles; sulfur; nitrogen; radicals; medicinal chemistry
Source: Crossref
Added: February 24, 2020

2014 journal article

A Rapid Synthesis of 4-Oxazolidinones: Total Synthesis of Synoxazolidinones A and B**

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 53(21), 5401–5404.

By: N. Shymanska n, I. An n & J. Pierce n 

co-author countries: United States of America 🇺🇸
author keywords: antimicrobial agents; heterocycles; natural products; stereoselectivity; total synthesis
MeSH headings : Acinetobacter baumannii / drug effects; Acylation; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Cyclization; Guanidine / analogs & derivatives; Guanidine / chemical synthesis; Guanidine / chemistry; Guanidine / pharmacology; Imines / chemistry; Oxazolidinones / chemical synthesis; Oxazolidinones / chemistry; Oxazolidinones / pharmacology; Staphylococcus aureus / drug effects; Stereoisomerism
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

Synthesis of Thiazolines by Copper Catalyzed Aminobromination of Thiohydroximic Acids

ORGANIC LETTERS, 16(7), 2074–2076.

By: B. Lemercier n & J. Pierce n 

co-author countries: United States of America 🇺🇸
MeSH headings : Alkenes / chemical synthesis; Amines / chemical synthesis; Catalysis; Combinatorial Chemistry Techniques; Copper / chemistry; Hydrocarbons, Brominated / chemical synthesis; Hydrocarbons, Brominated / chemistry; Molecular Structure; Oximes / chemistry; Stereoisomerism; Thiazolidines / chemical synthesis; Thiazolidines / chemistry
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

Synthesis of Thiohydroxamic Acids and Thiohydroximic Acid Derivatives

JOURNAL OF ORGANIC CHEMISTRY, 79(5), 2321–2330.

By: B. Lemercier n & J. Pierce n 

co-author countries: United States of America 🇺🇸
Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 journal article

Redesign of Glycopeptide Antibiotics: Back to the Future

ACS Chemical Biology, 7(5), 797–804.

By: R. James*, J. Pierce* , A. Okano*, J. Xie * & D. Boger *

co-author countries: United States of America 🇺🇸
MeSH headings : Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Drug Design; Enterococcus / drug effects; Glycopeptides / chemistry; Glycopeptides / pharmacology; Gram-Positive Bacterial Infections / drug therapy; Humans; Methicillin Resistance; Models, Molecular; Staphylococcal Infections / drug therapy; Staphylococcus aureus / drug effects; Vancomycin / analogs & derivatives; Vancomycin / pharmacology; Vancomycin Resistance
Sources: Crossref, ORCID
Added: August 28, 2020

2012 journal article

Silver(I)-Promoted Conversion of Thioamides to Amidines: Divergent Synthesis of a Key Series of Vancomycin Aglycon Residue 4 Amidines That Clarify Binding Behavior to Model Ligands

Journal of the American Chemical Society, 134(21), 8790–8793.

By: A. Okano*, R. James*, J. Pierce* , J. Xie * & D. Boger *

co-author countries: United States of America 🇺🇸
MeSH headings : Amidines / chemistry; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / metabolism; Anti-Bacterial Agents / pharmacology; Bacterial Proteins / metabolism; Catalysis; Chemistry Techniques, Synthetic; Drug Design; Drug Resistance, Bacterial / drug effects; Enterococcus faecalis / drug effects; Enterococcus faecalis / metabolism; Ligands; Peptidoglycan / chemistry; Peptidoglycan / pharmacology; Silver / chemistry; Thioamides / chemistry; Vancomycin / analogs & derivatives; Vancomycin / chemical synthesis; Vancomycin / chemistry; Vancomycin / metabolism; Vancomycin / pharmacology
Sources: Crossref, ORCID
Added: December 22, 2020

2012 journal article

Synthesis of a library of tricyclic azepinoisoindolinones

Beilstein Journal of Organic Chemistry, 8, 1091–1097.

By: B. Miller, S. Mao, K. Rosenker, J. Pierce*  & P. Wipf

author keywords: chemical diversity; epoxide aminolysis; hydrozirconation; isoindolinones; metathesis; N-acyliminium ion
Sources: Crossref, ORCID
Added: December 24, 2020

2012 journal article

Total Synthesis of [Ψ[C(═S)NH]Tpg4]Vancomycin Aglycon, [Ψ[C(═NH)NH]Tpg4]Vancomycin Aglycon, and Related Key Compounds: Reengineering Vancomycin for Dual d-Ala-d-Ala and d-Ala-d-Lac Binding

Journal of the American Chemical Society, 134(2), 1284–1297.

By: J. Xie *, A. Okano*, J. Pierce* , R. James*, S. Stamm*, C. Crane*, D. Boger *

co-author countries: United States of America 🇺🇸
MeSH headings : Amino Acid Sequence; Anti-Bacterial Agents / chemical synthesis; Drug Resistance, Bacterial; Models, Molecular; Molecular Structure; Peptidoglycan / chemistry; Protein Binding; Vancomycin / analogs & derivatives; Vancomycin / chemical synthesis
Sources: Crossref, ORCID
Added: December 22, 2020

2011 journal article

A Redesigned Vancomycin Engineered for Dual d-Ala-d-Ala and d-Ala-d-Lac Binding Exhibits Potent Antimicrobial Activity Against Vancomycin-Resistant Bacteria

Journal of the American Chemical Society, 133(35), 13946–13949.

By: J. Xie *, J. Pierce* , R. James*, A. Okano* & D. Boger *

co-author countries: United States of America 🇺🇸
MeSH headings : Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / metabolism; Bacteria / metabolism; Binding Sites; Cell Wall / metabolism; Dipeptides / metabolism; Peptidoglycan / metabolism; Vancomycin / chemistry; Vancomycin / metabolism; Vancomycin Resistance
Sources: Crossref, ORCID
Added: December 22, 2020

2011 journal article

Large-Scale Asymmetric Synthesis of the Bioprotective Agent JP4-039 and Analogs

Organic Letters, 13(9), 2318–2321.

co-author countries: United States of America 🇺🇸
MeSH headings : Amines / chemistry; Esters / chemistry; Models, Molecular; Molecular Structure; Nitrogen Oxides / chemical synthesis; Stereoisomerism
Sources: Crossref, ORCID
Added: August 28, 2020

2010 journal article

Synthesis and Evaluation of Selected Key Methyl Ether Derivatives of Vancomycin Aglycon

Journal of Medicinal Chemistry, 53(19), 7229–7235.

By: C. Crane*, J. Pierce* , S. Leung*, J. Tirado-Rives *, W. Jorgensen* & D. Boger *

co-author countries: United States of America 🇺🇸
MeSH headings : Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / pharmacology; Drug Resistance, Bacterial; Enterococcus faecalis / drug effects; Hydrophobic and Hydrophilic Interactions; Methyl Ethers / chemical synthesis; Methyl Ethers / pharmacology; Microbial Sensitivity Tests; Peptidoglycan / chemistry; Staphylococcus aureus / drug effects; Stereoisomerism; Structure-Activity Relationship; Thermodynamics; Vancomycin / analogs & derivatives; Vancomycin / chemical synthesis; Vancomycin / pharmacology
Sources: Crossref, ORCID
Added: August 28, 2020

2009 journal article

The Mitochondria-Targeted Nitroxide JP4-039 Augments Potentially Lethal Irradiation Damage Repair

In Vivo, 23(5), 717–726.

By: M. Rajagopalan, K. Gupta, M. Epperly, D. Franicola, X. Zhang, H. Wang, H. Zhao, V. Tyurin ...

Source: NC State University Libraries
Added: February 5, 2021

2008 journal article

Synthesis of Hydroxylated Bicyclic Amino Acids from l-Tyrosine: Octahydro-1 H-indole Carboxylates

The Journal of Organic Chemistry, 73(19), 7807–7810.

By: J. Pierce* , D. Kasi*, M. Fushimi*, A. Cuzzupe* & P. Wipf *

co-author countries: United States of America 🇺🇸
MeSH headings : Amino Acids / chemical synthesis; Amino Acids / chemistry; Bridged Bicyclo Compounds / chemical synthesis; Carboxylic Acids / chemistry; Hydroxylation; Indoles / chemistry; Stereoisomerism; Tyrosine / chemistry
Sources: Crossref, ORCID
Added: December 22, 2020

2008 journal article

The Mitochondrial Targeted GS-Nitroxide JP4-039 is Radioprotective In Vitro and In Vivo

International Journal of Radiation Oncology*Biology*Physics, 72(1), S82.

By: M. Epperly *, J. Pierce* , T. Dixon*, D. Franicola*, P. Wipf * & J. Greenberger *

co-author countries: United States of America 🇺🇸
Sources: Crossref, ORCID
Added: August 28, 2020

2007 journal article

Synthesis of functionalized isoindolinones: Addition of in situ generated organoalanes to acyliminium ions

Journal of Organometallic Chemistry, 692(21), 4618–4629.

By: J. Pierce* , D. Waller & P. Wipf

author keywords: isoindolinone; aluminum; zirconium; hydrozirconation; carbometallation; N-acyliminium ion
Sources: Crossref, ORCID
Added: August 28, 2020

2006 journal article

Expedient Synthesis of the α-C-Glycoside Analogue of the Immunostimulant Galactosylceramide (KRN7000)

Organic Letters, 8(15), 3375–3378.

By: P. Wipf * & J. Pierce* 

co-author countries: United States of America 🇺🇸
MeSH headings : Adjuvants, Immunologic / chemical synthesis; Adjuvants, Immunologic / pharmacology; Galactosylceramides / chemical synthesis; Galactosylceramides / pharmacology; Glycosides / chemical synthesis; Imines / chemistry; Molecular Structure; Stereoisomerism
Sources: Crossref, ORCID
Added: August 28, 2020

2005 journal article

Catalytic Reduction of Amides to Amines with Hydrosilanes Using a Triruthenium Carbonyl Cluster as the Catalyst​

Organic Syntheses, 82, 188.

By: Y. Motoyama, C. Itonaga, T. Ishida, M. Takasaki & H. Nagazhima

Ed(s): P. Wipf & J. Pierce 

Sources: Crossref, ORCID
Added: December 24, 2020

2005 journal article

Lipase-Catalyzed Resolution of 4-Trimethylsilyl-3-Butyn-2-ol and Conversion of the (R)-Enantiomer to (R)-3-Butyn-2-yl Mesylate and (P)-1-Tributylstannyl-1,2-Butadiene

Organic Syntheses, 4, 43–55.

By: J. Marshall* & H. Chobanian*

co-author countries: United States of America 🇺🇸
Sources: Crossref, ORCID
Added: December 24, 2020

2005 journal article

Silver(I)-Catalyzed Addition of Zirconocenes to Glycal Epoxides. A New Synthesis of α-C-Glycosides

Organic Letters, 7(3), 483–485.

By: P. Wipf *, J. Pierce*  & N. Zhuang*

co-author countries: United States of America 🇺🇸
MeSH headings : Catalysis; Epoxy Compounds / chemical synthesis; Glycosides / chemical synthesis; Indicators and Reagents; Molecular Conformation; Organometallic Compounds / chemistry; Silver / chemistry; Stereoisomerism; Zirconium / chemistry
Sources: Crossref, ORCID
Added: August 28, 2020

2005 journal article

Synthesis of Homoallylic Amines by Hydrozirconation−Imine Addition of Allenes

Organic Letters, 7(16), 3537–3540.

By: P. Wipf * & J. Pierce* 

co-author countries: United States of America 🇺🇸
Sources: Crossref, ORCID
Added: August 28, 2020

2003 journal article

Investigation of ligand loading and asymmetric amplification in CHAOx-catalyzed asymmetric diethylzinc additions

Tetrahedron: Asymmetry, 14(22), 3605–3611.

By: P. Wipf *, J. Pierce*  & X. Wang *

co-author countries: United States of America 🇺🇸
Sources: Crossref, ORCID
Added: December 24, 2020

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