Joshua Glenn Pierce

An enantioselective formal synthesis of thienamycin

TETRAHEDRON LETTERS, 144.

Expanded library of novel 2,3-pyrrolidinedione analogues exhibit anti-biofilm activity

Nie, M., Valdes-Pena, M. A., Frohock, B. H., Smits, E., Daiker, J. C., Gilbertie, J. M., … Pierce, J. G. (2024, February 1). BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Vol. 99.

Fighting fibrin with fibrin: Vancomycin delivery into coagulase-mediated <i>Staphylococcus aureus</i> biofilms via fibrin-based nanoparticle binding

Scull, G., Aligwekwe, A., Rey, Y., Koch, D., Nellenbach, K., Sheridan, A., … Brown, A. C. (2024, June 14). JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, Vol. 6.

Pyrrolidine-2,3-diones: heterocyclic scaffolds that inhibit and eradicate <i>S. aureus</i> biofilms

Valdes-Pena, M. A., Ratchford, A., Nie, M., Schnabel, L. V., & Pierce, J. G. (2024, September 23). CHEMICAL COMMUNICATIONS, Vol. 9.

Synthesis of Spiropyrrolines <i>via</i> One-Pot Tf₂O-Mediated Amide Activation/Formal [3+2]-Cycloaddition of α-Formylamino Ketones

Ho, K.-T., & Pierce, J. G. (2024, September 4). JOURNAL OF ORGANIC CHEMISTRY, Vol. 9.

Total Synthesis and Microbiological Evaluation of Leopolic Acid A and Analogues

Breunig, J. L., Valdes-Pena, M. A., Ratchford, A. W., & Pierce, J. G. (2024, January 12). ACS BIO & MED CHEM AU, Vol. 1.

Toxicology study of a tissue anchoring paclitaxel prodrug

BMC PHARMACOLOGY & TOXICOLOGY, 25(1).

3-Component Approach to 1,5-Dihydro-2<i>H</i>-pyrrol-2-one Heterocycles

ORGANIC SYNTHESES, 100, 418-+.

Photoredox Catalyzed C(sp<SUP>3</SUP>)-C(sp<SUP>3</SUP>) Coupling of α-Bromoesters and Triethylamine

JOURNAL OF ORGANIC CHEMISTRY, 89(1), 810–814.

Using Stem Mini-Organs to Find New Cures

Piedrahita, J., & Pierce, J. (2023, August 4).

Chemistry Drives Solutions to Our Planet’s Largest Problems: COVID-19 and Beyond

Pierce, J. (2022, June 22).

Synthesis provides insight into a traditional medicine

Onuska, N. P. R., & Pierce, J. G. (2022, June 30). NATURE, Vol. 606, pp. 869–870.

Tissue-reactive drugs enable materials-free local depots

JOURNAL OF CONTROLLED RELEASE, 343, 142–151.

Total Synthesis of Bipolamine I

Pierce, J. G., & Qiu, X. (2022, July 5). JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol. 7.

Leveraging Marine Natural Products as a Platform to Tackle Bacterial Resistance and Persistence

[Review of ]. ACCOUNTS OF CHEMICAL RESEARCH, 54(8), 1866–1877.

Rapid synthesis of the core scaffold of crinane and haemanthamine through a multi-component approach

TETRAHEDRON LETTERS, 75.

Restoring Carboxylates on Highly Modified Alginates Improves Gelation, Tissue Retention and Systemic Capture

Acta Biomaterialia, 138, 208–217.

Stereoselective Synthesis of the Spirocyclic gamma-Lactam Core of the Ansalactams

ORGANIC LETTERS, 23(24), 9559–9562.

Concise Synthesis and Antimicrobial Evaluation of the Guanidinium Alkaloid Batzelladine D: Development of a Stereodivergent Strategy

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 142(21), 9850–9857.

Design, synthesis, and evaluation of substrate - analogue inhibitors of Trypanosoma cruzi ribose 5-phosphate isomerase type B

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 32.

Front Cover: 5‐Benzylidene‐4‐Oxazolidinones Are Synergistic with Antibiotics for the Treatment of Staphylococcus aureus Biofilms (ChemBioChem 7/2020)

ChemBioChem.

Genetic Determinants of Salmonella Resistance to the Biofilm-Inhibitory Effects of a Synthetic 4-Oxazolidinone Analog

Applied and Environmental Microbiology, 86(20).

In Vitro Evaluation of a Novel Synthetic Bilirubin Analog as an Antioxidant and Cytoprotective Agent for Pancreatic Islet Transplantation

Cell Transplantation, 29, 096368972090641.

Stereocontrolled Synthesis of (±)-Melokhanine E via an Intramolecular Formal [3 + 2] Cycloaddition

Organic Letters, 22(2), 714–717.

Stereoselective, Multicomponent Approach to Quaternary Substituted Hydroindole Scaffolds

ORGANIC LETTERS, 22(13), 5079–5084.

5-Benzylidene-4-Oxazolidinones Are Synergistic with Antibiotics for the Treatment of Staphylococcus aureus Biofilms

CHEMBIOCHEM, Vol. 12.

5-Benzylidene-4-Oxazolidinones are Synergistic with Antibiotics for the Treatment of Staphylococcus Aureus Biofilms

[Preprint]. 9.

Accidental intoxications in toddlers: lack of cross-reactivity of vilazodone and its urinary metabolite M17 with drug of abuse screening immunoassays

BMC CLINICAL PATHOLOGY, 19.

Concise Synthesis and Antimicrobial Evaluation of the Guanidinium Alkaloid Batzelladine D

Pierce, J., & Lin, Y.-C. (2019, October 3). (Vol. 10). Vol. 10.

Concise Synthesis and Antimicrobial Evaluation of the Guanidinium Alkaloid Batzelladine D

Lin, Y.-C., Ribaucourt, A., Moazami, Y., & Pierce, J. (2019, October 4).

Expanded Structure-Activity Studies of Lipoxazolidinone Antibiotics

ACS MEDICINAL CHEMISTRY LETTERS, 10(3), 374-+.

Stereocontrolled Synthesis of Melokhanine E via an Intramolecular Formal [3+2] Cycloaddition

[Preprint]. 10.

3-Hydroxy-1,5-dihydro-2H-pyrrol-2-ones as novel antibacterial scaffolds against methicillin-resistant Staphylococcus aureus

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 28(16), 2732–2735.

Synthesis and Biological Evaluation of the Antimicrobial Natural Product Lipoxazolidinone A

Angewandte Chemie, 130(28), 8818–8822.

Synthesis and Biological Evaluation of the Antimicrobial Natural Product Lipoxazolidinone A

Mills, J. J., Robinson, K. R., Zehnder, T. E., & Pierce, J. G. (2018, April 9).

Synthesis and Biological Evaluation of the Antimicrobial Natural Product Lipoxazolidinone A

Angewandte Chemie International Edition, 57(28), 8682–8686.

5-Benzylidene-4-oxazolidinones potently inhibit biofilm formation in Methicillin-resistant Staphylococcus aureus

Chemical Communications, 53(53), 7353–7356.

Coupling of thioamides with 4-bromocrotonate esters and subsequent conjugate addition for the rapid one-pot synthesis of functionalized thiazolines

Tetrahedron Letters, 59(3), 277–279.

Direct Access to Highly Functionalized Heterocycles through the Condensation of Cyclic Imines and alpha-Oxoesters

JOURNAL OF ORGANIC CHEMISTRY, 82(24), 13714–13721.

How Cancer Cells Become Resistant to Cationic Lytic Peptides: It’s the Sugar!

Cell Chemical Biology, 24(2), 121–122.

Mast cell degranulation and calcium influx are inhibited by an Echinacea purpurea extract and the alkylamide dodeca-2E,4E-dienoic acid isobutylamide

Journal of Ethnopharmacology, 212, 166–174.

Stereoselective Synthesis of Quaternary Pyrrolidine-2,3-diones and beta-Amino Acids

ORGANIC LETTERS, 19(11), 2961–2964.

Structure, synthesis and biological properties of the pentacyclic guanidinium alkaloids

Bioorganic & Medicinal Chemistry, 25(11), 2817–2824.

Synthesis of Quaternary-Substituted Thiazolines via Halocyclization of S-Allyl Thioimidate Salts

The Journal of Organic Chemistry, 83(1), 12–22.

Examining ubiquitinated peptide enrichment efficiency through an epitope labeled protein

ANALYTICAL BIOCHEMISTRY, 512, 114–119.

Stereocontrolled Synthesis of (+)-Plagiogyrin A

Organic Letters, 18(20), 5308–5311.

Synthesis of 1,2,4-Oxadiazoles via DDQ-Mediated Oxidative Cyclization of Amidoximes

Synthesis, 48(12), 1902–1909.

Thiohydroximic acids: Versatile reagents for organic synthesis

Synlett, 27(2), 181–189.

Marine natural products synthesis as a driving force for chemical and biological discovery

Planta Medica, 81(11).

Rapid synthesis and antimicrobial activity of novel 4-oxazolidinone heterocycles

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 25(21), 4887–4889.

Synthesis and biological evaluation of a series of fatty acid amides from Echinacea

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 25(16), 3091–3094.

Synthesis of 1,4,2-Oxathiazoles via Oxidative Cyclization of Thiohydroximic Acids

ORGANIC LETTERS, 17(18), 4542–4545.

Synthesis of 2,3-Dihydro-1,3-oxazin-4-ones via a Mild Formal [4+2] Cycloaddition of Acylketenes with Aldimines

Synthesis, 47(21), 3363–3370.

Synthesis of the 5,6-Dihydroxymorpholin-3-one Fragment of Monanchocidin A

ORGANIC LETTERS, 17(4), 968–971.

Thiohydroximic Acids: Versatile Reagents for Organic Synthesis

Synlett, 27(02), 181–189.

A Rapid Synthesis of 4-Oxazolidinones: Total Synthesis of Synoxazolidinones A and B**

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 53(21), 5401–5404.

Synthesis of Thiazolines by Copper Catalyzed Aminobromination of Thiohydroximic Acids

ORGANIC LETTERS, 16(7), 2074–2076.

Synthesis of Thiohydroxamic Acids and Thiohydroximic Acid Derivatives

JOURNAL OF ORGANIC CHEMISTRY, 79(5), 2321–2330.

Redesign of Glycopeptide Antibiotics: Back to the Future

ACS Chemical Biology, 7(5), 797–804.

Silver(I)-Promoted Conversion of Thioamides to Amidines: Divergent Synthesis of a Key Series of Vancomycin Aglycon Residue 4 Amidines That Clarify Binding Behavior to Model Ligands

Journal of the American Chemical Society, 134(21), 8790–8793.

Synthesis of a library of tricyclic azepinoisoindolinones

Beilstein Journal of Organic Chemistry, 8, 1091–1097.

A Redesigned Vancomycin Engineered for Dual d-Ala-d-Ala and d-Ala-d-Lac Binding Exhibits Potent Antimicrobial Activity Against Vancomycin-Resistant Bacteria

Journal of the American Chemical Society, 133(35), 13946–13949.

Large-Scale Asymmetric Synthesis of the Bioprotective Agent JP4-039 and Analogs

Organic Letters, 13(9), 2318–2321.

Total Synthesis of [Ψ[C(═S)NH]Tpg4]Vancomycin Aglycon, [Ψ[C(═NH)NH]Tpg4]Vancomycin Aglycon, and Related Key Compounds: Reengineering Vancomycin for Dual d-Ala-d-Ala and d-Ala-d-Lac Binding

Journal of the American Chemical Society, 134(2), 1284–1297.

Synthesis and Evaluation of Selected Key Methyl Ether Derivatives of Vancomycin Aglycon

Journal of Medicinal Chemistry, 53(19), 7229–7235.

The Mitochondria-Targeted Nitroxide JP4-039 Augments Potentially Lethal Irradiation Damage Repair

In Vivo, 23(5), 717–726.

1,4-Oxazines and their Benzo Derivatives

In Comprehensive Heterocyclic Chemistry IV.

Synthesis of Hydroxylated Bicyclic Amino Acids from l-Tyrosine: Octahydro-1 H-indole Carboxylates

The Journal of Organic Chemistry, 73(19), 7807–7810.

The Mitochondrial Targeted GS-Nitroxide JP4-039 is Radioprotective In Vitro and In Vivo

International Journal of Radiation Oncology*Biology*Physics, 72(1), S82.

Synthesis of functionalized isoindolinones: Addition of in situ generated organoalanes to acyliminium ions

Journal of Organometallic Chemistry, 692(21), 4618–4629.

Expedient Synthesis of the α-C-Glycoside Analogue of the Immunostimulant Galactosylceramide (KRN7000)

Organic Letters, 8(15), 3375–3378.

Catalytic Reduction of Amides to Amines with Hydrosilanes Using a Triruthenium Carbonyl Cluster as the Catalyst​

Organic Syntheses, 82, 188.

Lipase-Catalyzed Resolution of 4-Trimethylsilyl-3-Butyn-2-ol and Conversion of the (R)-Enantiomer to (R)-3-Butyn-2-yl Mesylate and (P)-1-Tributylstannyl-1,2-Butadiene

Organic Syntheses, 4, 43–55.

Silver(I)-Catalyzed Addition of Zirconocenes to Glycal Epoxides. A New Synthesis of α-C-Glycosides

Organic Letters, 7(3), 483–485.

Synthesis of Homoallylic Amines by Hydrozirconation−Imine Addition of Allenes

Organic Letters, 7(16), 3537–3540.

Investigation of ligand loading and asymmetric amplification in CHAOx-catalyzed asymmetric diethylzinc additions

Tetrahedron: Asymmetry, 14(22), 3605–3611.