Works (66)

Updated: April 11th, 2023 10:13

2022 article

Chemistry Drives Solutions to Our Planet’s Largest Problems: COVID-19 and Beyond

Pierce, J. (2022, June 22).

By: J. Pierce

Source: ORCID
Added: August 17, 2022

2022 journal article

Restoring Carboxylates on Highly Modified Alginates Improves Gelation, Tissue Retention and Systemic Capture

ACTA BIOMATERIALIA, 138, 208–217.

By: C. Moody, A. Brown, N. Massaro, A. Patel, P. Agarwalla, A. Simpson n, A. Brown n, H. Zheng, J. Pierce, Y. Brudno

author keywords: Alginate; Click chemistry; Bioconjugation; Ionic cross-linking; Drug capture
Sources: ORCID, Web Of Science
Added: October 31, 2021

2022 article

Synthesis provides insight into a traditional medicine

Onuska, N. P. R., & Pierce, J. G. (2022, June 30). NATURE, Vol. 606, pp. 869–870.

By: N. Onuska & J. Pierce

author keywords: Chemical biology; Organic chemistry; Chemistry; Synthesis
Sources: Web Of Science, ORCID
Added: July 11, 2022

2022 journal article

Tissue-reactive drugs enable materials-free local depots

JOURNAL OF CONTROLLED RELEASE, 343, 142–151.

By: S. Pandit, S. Palvai, N. Massaro, J. Pierce & Y. Brudno

author keywords: Sustained release; Materials-free delivery; Paclitaxel; Pancreatic cancer; Extracellular matrix; N-hydroxysuccinimide ester
Sources: Web Of Science, ORCID
Added: May 2, 2022

2022 article

Total Synthesis of Bipolamine I

Pierce, J. G., & Qiu, X. (2022, July 5). JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol. 7.

By: J. Pierce & X. Qiu

Sources: ORCID, Web Of Science
Added: July 6, 2022

2021 journal article

Design, synthesis, and evaluation of substrate - analogue inhibitors of Trypanosoma cruzi ribose 5-phosphate isomerase type B

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 32.

By: S. Natalia Gonzalez*, J. Mills n, D. Maugeri*, C. Olaya n, B. Laguera*, J. Enders, J. Sherman*, A. Rodriguez* ...

author keywords: Neglected tropical diseases; Chagas' disease; Trypanosoma cruzi; Amastigote; Trypomastigote; Isomerase; Substrate-analogue inhibitors; Competitive inhibition; Trypsin digestion LC-MS/MS
Sources: ORCID, Web Of Science
Added: December 15, 2020

2021 review

Leveraging Marine Natural Products as a Platform to Tackle Bacterial Resistance and Persistence

[Review of ]. ACCOUNTS OF CHEMICAL RESEARCH, 54(8), 1866–1877.

By: M. Valdes-Pena n, N. Massaro, Y. Lin & J. Pierce

Sources: ORCID, Web Of Science
Added: March 19, 2021

2021 journal article

Rapid synthesis of the core scaffold of crinane and haemanthamine through a multi-component approach

TETRAHEDRON LETTERS, 75.

By: N. Massaro & J. Pierce

author keywords: Amaryllidaceae alkaloids; Heterocycles; Multicomponent; Natural products; Total synthesis
Sources: ORCID, Web Of Science
Added: May 25, 2021

2021 journal article

Stereoselective Synthesis of the Spirocyclic gamma-Lactam Core of the Ansalactams

ORGANIC LETTERS, 23(24), 9559–9562.

By: Z. Liang, Y. Lin & J. Pierce

Sources: ORCID, Web Of Science
Added: December 1, 2021

2020 chapter

1,4-Oxazines and their Benzo Derivatives

In Comprehensive Heterocyclic Chemistry IV.

By: Y. Lin, C. Martinez-Brokaw & J. Pierce

Sources: Crossref, ORCID
Added: December 24, 2020

2020 journal article

Concise Synthesis and Antimicrobial Evaluation of the Guanidinium Alkaloid Batzelladine D: Development of a Stereodivergent Strategy

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 142(21), 9850–9857.

By: Y. Lin, A. Ribaucourt n, Y. Moazami & J. Pierce

Sources: Web Of Science, ORCID
Added: June 22, 2020

2020 journal article

Front Cover: 5‐Benzylidene‐4‐Oxazolidinones Are Synergistic with Antibiotics for the Treatment of Staphylococcus aureus Biofilms (ChemBioChem 7/2020)

ChemBioChem, 21(7), 883–883.

By: B. Frohock n, J. Gilbertie n, J. Daiker n, L. Schnabel n & J. Pierce

Source: ORCID
Added: December 15, 2020

2020 journal article

Genetic Determinants of Salmonella Resistance to the Biofilm-Inhibitory Effects of a Synthetic 4-Oxazolidinone Analog

Applied and Environmental Microbiology, 86(20).

By: K. Griewisch n, J. Pierce & J. Elfenbein

Ed(s): M. Kivisaar

author keywords: Salmonella; antimicrobial resistance; biofilm; genetics
Sources: ORCID, Crossref, Web Of Science
Added: November 16, 2020

2020 journal article

In Vitro Evaluation of a Novel Synthetic Bilirubin Analog as an Antioxidant and Cytoprotective Agent for Pancreatic Islet Transplantation

Cell Transplantation, 29, 096368972090641.

By: E. Luckring n, P. Parker n, H. Hani*, M. Grace, M. Lila n, J. Pierce, C. Adin*

Source: ORCID
Added: July 9, 2020

2020 journal article

Stereocontrolled Synthesis of (±)-Melokhanine E via an Intramolecular Formal [3 + 2] Cycloaddition

Organic Letters, 22(2), 714–717.

By: A. Cholewczynski n, P. Williams n & J. Pierce

Source: ORCID
Added: December 15, 2020

2020 journal article

Stereoselective, Multicomponent Approach to Quaternary Substituted Hydroindole Scaffolds

ORGANIC LETTERS, 22(13), 5079–5084.

By: N. Massaro & J. Pierce

Sources: Web Of Science, ORCID
Added: August 3, 2020

2019 article

5-Benzylidene-4-Oxazolidinones Are Synergistic with Antibiotics for the Treatment of Staphylococcus aureus Biofilms

CHEMBIOCHEM, Vol. 12.

Sources: ORCID, Web Of Science
Added: January 13, 2020

2019 journal article

5-Benzylidene-4-Oxazolidinones are Synergistic with Antibiotics for the Treatment of Staphylococcus Aureus Biofilms

[Preprint]. 9.

By: B. Frohock n, J. Gilbertie n, J. Daiker n, L. Schnabel n & J. Pierce

Sources: Crossref, ORCID
Added: December 22, 2020

2019 journal article

Accidental intoxications in toddlers: lack of cross-reactivity of vilazodone and its urinary metabolite M17 with drug of abuse screening immunoassays

BMC CLINICAL PATHOLOGY, 19.

By: C. Martinez-Brokaw n, J. Radke*, J. Pierce, A. Ehlers*, S. Ekins*, K. Wood*, J. Maakestad*, J. Rymer*, K. Tamama*, M. Krasowski*

author keywords: Amphetamines; False positive reactions; Immunoassay; Similarity; Toxicology
Sources: Web Of Science, ORCID
Added: March 4, 2019

2019 article

Concise Synthesis and Antimicrobial Evaluation of the Guanidinium Alkaloid Batzelladine D

Pierce, J., & Lin, Y.-C. (2019, October 3). (Vol. 10). Vol. 10.

By: J. Pierce & Y. Lin n

Source: ORCID
Added: October 22, 2021

2019 article

Concise Synthesis and Antimicrobial Evaluation of the Guanidinium Alkaloid Batzelladine D

Lin, Y.-C., Ribaucourt, A., Moazami, Y., & Pierce, J. (2019, October 4).

By: Y. Lin, A. Ribaucourt, Y. Moazami & J. Pierce

Source: ORCID
Added: October 22, 2021

2019 journal article

Expanded Structure-Activity Studies of Lipoxazolidinone Antibiotics

ACS MEDICINAL CHEMISTRY LETTERS, 10(3), 374-+.

By: K. Robinson, J. Mills n & J. Pierce

author keywords: Oxazolidinones; antibiotics; MRSA; heterocycles
Sources: Web Of Science, ORCID
Added: April 2, 2019

2019 journal article

Stereocontrolled Synthesis of Melokhanine E via an Intramolecular Formal [3+2] Cycloaddition

[Preprint]. 10.

By: J. Pierce, A. Cholewczynski & P. Williams

Sources: Crossref, ORCID
Added: December 22, 2020

2018 journal article

3-Hydroxy-1,5-dihydro-2H-pyrrol-2-ones as novel antibacterial scaffolds against methicillin-resistant Staphylococcus aureus

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 28(16), 2732–2735.

By: A. Cusumano n & J. Pierce

author keywords: Natural products; Antibiotics; Heterocycles; Cyclization; Medicinal chemistry
Sources: Web Of Science, ORCID
Added: October 19, 2018

2018 journal article

Coupling of thioamides with 4-bromocrotonate esters and subsequent conjugate addition for the rapid one-pot synthesis of functionalized thiazolines

Tetrahedron Letters, 59(3), 277–279.

By: P. Parker n, Y. Ge n & J. Pierce

author keywords: Heterocycle; Natural products; Medicinal chemistry; Alkylation; Thiazoline
Sources: Crossref, ORCID
Added: February 24, 2020

2018 journal article

Mast cell degranulation and calcium influx are inhibited by an Echinacea purpurea extract and the alkylamide dodeca-2E,4E-dienoic acid isobutylamide

Journal of Ethnopharmacology, 212, 166–174.

By: T. Gulledge n, N. Collette n, E. Mackey*, S. Johnstone n, Y. Moazami n, D. Todd*, A. Moeser*, J. Pierce, N. Cech*, S. Laster

author keywords: Alkylamide; Echinacea purpurea; Allergies; Inflammation; Mast cell
Sources: Crossref, ORCID
Added: February 21, 2020

2018 journal article

Synthesis and Biological Evaluation of the Antimicrobial Natural Product Lipoxazolidinone A

Angewandte Chemie, 130(28), 8818–8822.

By: J. Mills n, K. Robinson n, T. Zehnder n & J. Pierce

Source: ORCID
Added: December 15, 2020

2018 article

Synthesis and Biological Evaluation of the Antimicrobial Natural Product Lipoxazolidinone A

Mills, J. J., Robinson, K. R., Zehnder, T. E., & Pierce, J. G. (2018, April 9).

By: J. Mills, K. Robinson, T. Zehnder & J. Pierce

Source: ORCID
Added: October 21, 2021

2018 journal article

Synthesis and Biological Evaluation of the Antimicrobial Natural Product Lipoxazolidinone A

Angewandte Chemie International Edition, 57(28), 8682–8686.

By: J. Mills n, K. Robinson, T. Zehnder n & J. Pierce

author keywords: antibiotics; cyclization; heterocycles; medicinal chemistry; natural products
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2018 journal article

Synthesis of Quaternary-Substituted Thiazolines via Halocyclization of S-Allyl Thioimidate Salts

The Journal of Organic Chemistry, 83(1), 12–22.

By: P. Parker n, B. Lemercier n & J. Pierce

Sources: Crossref, ORCID
Added: December 11, 2020

2017 journal article

5-Benzylidene-4-oxazolidinones potently inhibit biofilm formation in Methicillin-resistant Staphylococcus aureus

Chemical Communications, 53(53), 7353–7356.

By: G. Edwards n, N. Shymanska n & J. Pierce

Sources: Crossref, ORCID
Added: February 24, 2020

2017 journal article

Direct Access to Highly Functionalized Heterocycles through the Condensation of Cyclic Imines and alpha-Oxoesters

JOURNAL OF ORGANIC CHEMISTRY, 82(24), 13714–13721.

By: A. Cusumano n, M. Boudreau n & J. Pierce

Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

How Cancer Cells Become Resistant to Cationic Lytic Peptides: It’s the Sugar!

Cell Chemical Biology, 24(2), 121–122.

By: J. Pierce

Sources: Crossref, ORCID
Added: December 11, 2020

2017 journal article

Stereoselective Synthesis of Quaternary Pyrrolidine-2,3-diones and beta-Amino Acids

ORGANIC LETTERS, 19(11), 2961–2964.

By: N. Shymanska & J. Pierce

Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

Structure, synthesis and biological properties of the pentacyclic guanidinium alkaloids

Bioorganic & Medicinal Chemistry, 25(11), 2817–2824.

By: Y. Shi n, Y. Moazami n & J. Pierce

author keywords: Guanidinium alkaloids; Marine natural products; Chemical probe; Structure-activity relationship; Mechanism of action
Sources: Crossref, ORCID
Added: February 24, 2020

2016 journal article

Examining ubiquitinated peptide enrichment efficiency through an epitope labeled protein

ANALYTICAL BIOCHEMISTRY, 512, 114–119.

By: J. Parker n, Y. Oh, Y. Moazami, J. Pierce, P. Loziuk, R. Dean, D. Muddiman

author keywords: Ubiquitination; Gly-Gly enrichment; Enrichment efficiency
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

Stereocontrolled Synthesis of (+)-Plagiogyrin A

Organic Letters, 18(20), 5308–5311.

By: Y. Shi n & J. Pierce

Sources: Crossref, ORCID
Added: February 24, 2020

2016 journal article

Synthesis of 1,2,4-Oxadiazoles via DDQ-Mediated Oxidative Cyclization of Amidoximes

Synthesis, 48(12), 1902–1909.

By: J. Pierce & P. Parker

author keywords: oxidation; cyclization; heterocycles; radicals; medicinal chemistry
Sources: Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2016 journal article

Thiohydroximic acids: Versatile reagents for organic synthesis

Synlett, 27(2), 181–189.

By: B. Lemercier & J. Pierce

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Marine natural products synthesis as a driving force for chemical and biological discovery

Planta Medica, 81(11).

By: J. Pierce, N. Shymanska & G. Edwards

Sources: Crossref, ORCID
Added: February 24, 2020

2015 journal article

Rapid synthesis and antimicrobial activity of novel 4-oxazolidinone heterocycles

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 25(21), 4887–4889.

author keywords: Antibiotic; Heterocycle; Oxazolidinone; Natural products
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

Synthesis and biological evaluation of a series of fatty acid amides from Echinacea

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 25(16), 3091–3094.

By: Y. Moazami, T. Gulledge, S. Laster & J. Pierce

author keywords: Echinacea; Alkylamide; TNF-alpha; Anti-inflammatory; Cytokine
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

Synthesis of 1,4,2-Oxathiazoles via Oxidative Cyclization of Thiohydroximic Acids

ORGANIC LETTERS, 17(18), 4542–4545.

By: B. Lemercier & J. Pierce

Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

Synthesis of 2,3-Dihydro-1,3-oxazin-4-ones via a Mild Formal [4+2] Cycloaddition of Acylketenes with Aldimines

Synthesis, 47(21), 3363–3370.

By: J. Pierce & Y. Moazami

author keywords: cycloaddition; heterocycles; imines; transition metals; acylation
Sources: Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2015 journal article

Synthesis of the 5,6-Dihydroxymorpholin-3-one Fragment of Monanchocidin A

ORGANIC LETTERS, 17(4), 968–971.

By: Y. Shi & J. Pierce

Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

Thiohydroximic Acids: Versatile Reagents for Organic Synthesis

Synlett, 27(02), 181–189.

By: J. Pierce & B. Lemercier

author keywords: heterocycles; sulfur; nitrogen; radicals; medicinal chemistry
Source: Crossref
Added: February 24, 2020

2014 journal article

A Rapid Synthesis of 4-Oxazolidinones: Total Synthesis of Synoxazolidinones A and B**

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 53(21), 5401–5404.

By: N. Shymanska, I. An n & J. Pierce

author keywords: antimicrobial agents; heterocycles; natural products; stereoselectivity; total synthesis
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

Synthesis of Thiazolines by Copper Catalyzed Aminobromination of Thiohydroximic Acids

ORGANIC LETTERS, 16(7), 2074–2076.

By: B. Lemercier & J. Pierce

Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

Synthesis of Thiohydroxamic Acids and Thiohydroximic Acid Derivatives

JOURNAL OF ORGANIC CHEMISTRY, 79(5), 2321–2330.

By: B. Lemercier & J. Pierce

Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 journal article

Redesign of Glycopeptide Antibiotics: Back to the Future

ACS Chemical Biology, 7(5), 797–804.

By: R. James*, J. Pierce, A. Okano*, J. Xie* & D. Boger*

Sources: Crossref, ORCID
Added: August 28, 2020

2012 journal article

Silver(I)-Promoted Conversion of Thioamides to Amidines: Divergent Synthesis of a Key Series of Vancomycin Aglycon Residue 4 Amidines That Clarify Binding Behavior to Model Ligands

Journal of the American Chemical Society, 134(21), 8790–8793.

By: A. Okano*, R. James*, J. Pierce, J. Xie* & D. Boger*

Sources: Crossref, ORCID
Added: December 22, 2020

2012 journal article

Synthesis of a library of tricyclic azepinoisoindolinones

Beilstein Journal of Organic Chemistry, 8, 1091–1097.

By: B. Miller, S. Mao, K. Rosenker, J. Pierce & P. Wipf

author keywords: chemical diversity; epoxide aminolysis; hydrozirconation; isoindolinones; metathesis; N-acyliminium ion
Sources: Crossref, ORCID
Added: December 24, 2020

2012 journal article

Total Synthesis of [Ψ[C(═S)NH]Tpg4]Vancomycin Aglycon, [Ψ[C(═NH)NH]Tpg4]Vancomycin Aglycon, and Related Key Compounds: Reengineering Vancomycin for Dual d-Ala-d-Ala and d-Ala-d-Lac Binding

Journal of the American Chemical Society, 134(2), 1284–1297.

By: J. Xie*, A. Okano*, J. Pierce, R. James*, S. Stamm*, C. Crane*, D. Boger*

Sources: Crossref, ORCID
Added: December 22, 2020

2011 journal article

A Redesigned Vancomycin Engineered for Dual d-Ala-d-Ala and d-Ala-d-Lac Binding Exhibits Potent Antimicrobial Activity Against Vancomycin-Resistant Bacteria

Journal of the American Chemical Society, 133(35), 13946–13949.

By: J. Xie*, J. Pierce, R. James*, A. Okano* & D. Boger*

Sources: Crossref, ORCID
Added: December 22, 2020

2011 journal article

Large-Scale Asymmetric Synthesis of the Bioprotective Agent JP4-039 and Analogs

Organic Letters, 13(9), 2318–2321.

By: M. Frantz*, J. Pierce, J. Pierce*, L. Kangying*, W. Qingwei*, M. Johnson*, P. Wipf*

Sources: Crossref, ORCID
Added: August 28, 2020

2010 journal article

Synthesis and Evaluation of Selected Key Methyl Ether Derivatives of Vancomycin Aglycon

Journal of Medicinal Chemistry, 53(19), 7229–7235.

By: C. Crane*, J. Pierce, S. Leung*, J. Tirado-Rives*, W. Jorgensen* & D. Boger*

Sources: Crossref, ORCID
Added: August 28, 2020

2009 journal article

The Mitochondria-Targeted Nitroxide JP4-039 Augments Potentially Lethal Irradiation Damage Repair

In Vivo, 23(5), 717–726.

By: M. Rajagopalan, K. Gupta, M. Epperly, D. Franicola, X. Zhang, H. Wang, H. Zhao, V. Tyurin ...

Source: NC State University Libraries
Added: February 5, 2021

2008 journal article

Synthesis of Hydroxylated Bicyclic Amino Acids from l-Tyrosine: Octahydro-1 H-indole Carboxylates

The Journal of Organic Chemistry, 73(19), 7807–7810.

By: J. Pierce, D. Kasi*, M. Fushimi*, A. Cuzzupe* & P. Wipf*

Sources: Crossref, ORCID
Added: December 22, 2020

2008 journal article

The Mitochondrial Targeted GS-Nitroxide JP4-039 is Radioprotective In Vitro and In Vivo

International Journal of Radiation Oncology*Biology*Physics, 72(1), S82.

By: M. Epperly*, J. Pierce, T. Dixon*, D. Franicola*, P. Wipf* & J. Greenberger*

Sources: Crossref, ORCID
Added: August 28, 2020

2007 journal article

Synthesis of functionalized isoindolinones: Addition of in situ generated organoalanes to acyliminium ions

Journal of Organometallic Chemistry, 692(21), 4618–4629.

By: J. Pierce, D. Waller* & P. Wipf*

author keywords: isoindolinone; aluminum; zirconium; hydrozirconation; carbometallation; N-acyliminium ion
Sources: Crossref, ORCID
Added: August 28, 2020

2006 journal article

Expedient Synthesis of the α-C-Glycoside Analogue of the Immunostimulant Galactosylceramide (KRN7000)

Organic Letters, 8(15), 3375–3378.

By: P. Wipf* & J. Pierce

Sources: Crossref, ORCID
Added: August 28, 2020

2005 journal article

Catalytic Reduction of Amides to Amines with Hydrosilanes Using a Triruthenium Carbonyl Cluster as the Catalyst​

Organic Syntheses, 82, 188.

By: Y. Motoyama, C. Itonaga, T. Ishida, M. Takasaki & H. Nagazhima

Ed(s): P. Wipf & J. Pierce

Sources: Crossref, ORCID
Added: December 24, 2020

2005 journal article

Lipase-Catalyzed Resolution of 4-Trimethylsilyl-3-Butyn-2-ol and Conversion of the (R)-Enantiomer to (R)-3-Butyn-2-yl Mesylate and (P)-1-Tributylstannyl-1,2-Butadiene

Organic Syntheses, 4, 43–55.

By: J. Marshall* & H. Chobanian*

Sources: Crossref, ORCID
Added: December 24, 2020

2005 journal article

Silver(I)-Catalyzed Addition of Zirconocenes to Glycal Epoxides. A New Synthesis of α-C-Glycosides

Organic Letters, 7(3), 483–485.

By: P. Wipf*, J. Pierce & N. Zhuang*

Sources: Crossref, ORCID
Added: August 28, 2020

2005 journal article

Synthesis of Homoallylic Amines by Hydrozirconation−Imine Addition of Allenes

Organic Letters, 7(16), 3537–3540.

By: P. Wipf* & J. Pierce

Sources: Crossref, ORCID
Added: August 28, 2020

2003 journal article

Investigation of ligand loading and asymmetric amplification in CHAOx-catalyzed asymmetric diethylzinc additions

Tetrahedron: Asymmetry, 14(22), 3605–3611.

By: P. Wipf*, J. Pierce & X. Wang*

Sources: Crossref, ORCID
Added: December 24, 2020