Julie Gras-Najjar

Works (2)

Updated: July 5th, 2023 15:44

2018 journal article

NMDA Receptor-Dependent Cholinergic Modulation of Mesolimbic Dopamine Cell Bodies: Neurochemical and Behavioral Studies

ACS Chemical Neuroscience, 10(3), 1497–1505.

By: M. Spanos  n, X. Xie n, J. Gras-Najjar n, S. White n & L. Sombers n 

author keywords: Glutamate; acetylcholine; dopamine; sensory stimuli; ventral tegmental area
MeSH headings : Animals; Cell Body / drug effects; Cell Body / metabolism; Cholinergic Agonists / administration & dosage; Dopamine / metabolism; Male; Microinjections / methods; N-Methylaspartate / administration & dosage; Photic Stimulation / methods; Psychomotor Performance / drug effects; Psychomotor Performance / physiology; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate / agonists; Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors; Receptors, N-Methyl-D-Aspartate / metabolism; Ventral Tegmental Area / drug effects; Ventral Tegmental Area / metabolism
TL;DR: It is suggested that acetylcholine and glutamate synergistically act at dopamine cells in the VTA to modulate VTA-NAc shell dopaminergic output, and this underlies motivation to lever press for a motivationally neutral visual stimulus. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, Crossref
Added: April 9, 2019

2013 journal article

Quantitation of Hydrogen Peroxide Fluctuations and Their Modulation of Dopamine Dynamics in the Rat Dorsal Striatum Using Fast-Scan Cyclic Voltammetry

ACS CHEMICAL NEUROSCIENCE, 4(5), 782–789.

By: M. Spanos  n, J. Gras-Najjar n, J. Letchworth n, A. Sanford n, J. Toups n & L. Sombers n 

author keywords: oxidative stress; reactive oxygen species; H2O2; FSCV; Parkinson's disease; basal dopamine concentrations
MeSH headings : Animals; Dopamine / metabolism; Electric Stimulation; Electrochemical Techniques; Hydrogen Peroxide / metabolism; Male; Neostriatum / drug effects; Neostriatum / metabolism; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species / metabolism; Rotenone / pharmacology; Uncoupling Agents / pharmacology
TL;DR: Increases in endogenous H2O2 in the dorsal striatum attenuated electrically evoked DA release, and also decreased basal DA levels in this brain region will help to disambiguate the chemical mechanisms underlying the progression of neurodegenerative disease states, such as Parkinson's disease, that involve oxidative stress. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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