@article{piazza_mcanulty_early_guevar_2023, title={Craniectomies for Dogs With Skull Multilobular Osteochondrosarcoma Using the Misonix Bone Scalpel: Cadaveric Evaluation and Retrospective Case Series}, volume={53}, ISSN={["1946-9837"]}, DOI={10.1016/j.tcam.2023.100772}, abstractNote={To evaluate the Misonix bone scalpel (MBS) for craniotomies in dogs and describe clinical findings and surgical experience in 3 dogs with large multilobular osteochondrosarcoma (MLO) of the skull. Cadaver evaluation and retrospective case series. One canine cadaver; 3 client-owned dogs. Craniotomies of different sizes and at different locations were performed with MBS. Dural tear and bone discoloration were recorded. Clinical, imaging, and surgical findings of dogs diagnosed with MLO and where MBS was used for craniectomies were retrospectively included. Cadaveric evaluation identified MBS as an efficient tool for rapid craniectomies (>5minutes) albeit dural tears and some small foci of bone discoloration were observed. Craniectomies could be performed without complications in 3 dogs with MLO without dural tear or bone discoloration. .Excision was in complete in all cases. The short-term outcome was good, and the long-term outcome was fair to good. Piezoelectric bone surgery with the Misonix bone scalpel is an alternative technology to perform craniectomies in dogs. It was not associated with complications in 3 dogs diagnosed and surgically treated for MLO. Dural tears and suspected bone necrosis can occur. Great care should be taken when using CT to establish disease free surgical osteotomy.}, journal={TOPICS IN COMPANION ANIMAL MEDICINE}, author={Piazza, Alexander M. and McAnulty, Jonathan F. and Early, Peter and Guevar, Julien}, year={2023} }
 @article{durand_keenihan_schweizer_maiolini_guevar_oevermann_gutierrez-quintana_2022, title={Clinical and magnetic resonance imaging features of lymphoma involving the nervous system in cats}, ISSN={["1939-1676"]}, DOI={10.1111/jvim.16350}, abstractNote={AbstractBackgroundLymphoma is the most common spinal cord neoplasm and second most common intracranial tumor in cats, but description of specific magnetic resonance imaging (MRI) features is lacking.ObjectiveDescribe the clinical and MRI features of lymphoma affecting the central (CNS) or peripheral (PNS) nervous system or both in cats.AnimalsThirty‐one cats with confirmed cytological or histopathological diagnosis or both of lymphoma involving the CNS or PNS or both, and MRI findings of the lesions.MethodsMulticenter retrospective descriptive study. Signalment and medical information were recorded. Magnetic resonance imaging findings were reviewed by 3 observers following a list of predefined criteria and consensus was sought. Frequency distributions of the different categorical data were reported.ResultsMedian duration of clinical signs at time of presentation was 14 days (range, 1‐90). Neurological examination was abnormal in 30/31 cats. On MRI, lesions affecting the CNS were diagnosed in 18/31 cats, lesions in both CNS and PNS in 12/31, and lesions in the PNS only in 1/31. Intracranial lesions were diagnosed in 22 cats (extra‐axial, 7/22; intra‐axial, 2/22; mixed, 13/22), and spinal lesions were diagnosed in 12 (6/12 involving the conus medullaris and lumbosacral plexuses). Infiltration of adjacent extra‐neural tissue was present in 11/31 cases. Contrast enhancement was seen in all lesions, being marked in 25/30. Meningeal enhancement was present in all but 2 cases. Several distinct MRI patterns were observed.Conclusions and Clinical ImportanceNervous system lymphoma in cats has a wide range of MRI features, of which none is pathognomonic. However, together with clinical data and cerebrospinal fluid (CSF) analysis, MRI may provide a strong tentative antemortem diagnosis.}, journal={JOURNAL OF VETERINARY INTERNAL MEDICINE}, author={Durand, Alexane and Keenihan, Erin and Schweizer, Daniela and Maiolini, Arianna and Guevar, Julien and Oevermann, Anna and Gutierrez-Quintana, Rodrigo}, year={2022}, month={Jan} }
 @article{silva_guevar_jose-lopez_de decker_brocal_fuente_durand_forterre_olby_gutierrez-quintana_2022, title={Clinical signs, MRI findings and long-term outcomes of foraminal and far lateral thoracolumbar intervertebral disc herniations in dogs}, volume={3}, ISSN={["2042-7670"]}, url={https://doi.org/10.1002/vetr.1529}, DOI={10.1002/vetr.1529}, abstractNote={AbstractBackgroundAs they have been seldomly described in the veterinary literature, the aims of this retrospective study were to describe the clinical presentation, MRI findings and long‐term outcome after medical or surgical treatment of dogs presenting with foraminal and far lateral thoracolumbar intervertebral disc herniations.MethodsRetrospective multicentre study of dogs diagnosed with foraminal and far lateral thoracolumbar intervertebral disc herniations between 2009 and 2020 in seven referral hospitals.ResultsThirty‐seven dogs were included. Dachshunds and mixed breeds were most affected. Median age at presentation and duration of clinical signs were 6 years and 14 days, respectively. Pain was the most frequent clinical finding (92%), particularly on spinal palpation and/or hip manipulation, followed by pelvic limb lameness (71%). Eighty‐seven percent of herniations occurred at L5‐L6 or L6‐L7. A good to excellent outcome was seen in 95% of surgically and 90% of medically treated dogs.ConclusionAlthough much less frequently recognised than herniation affecting the vertebral canal, foraminal and far lateral thoracolumbar intervertebral disc herniations should be considered in the differential diagnosis list of chondrodystrophic dogs presenting with pain and pelvic limb lameness. Most dogs had a good to excellent outcome following medical or surgical treatment.}, journal={VETERINARY RECORD}, author={Silva, Sara and Guevar, Julien and Jose-Lopez, Roberto and De Decker, Steven and Brocal, Josep and Fuente, Cristian and Durand, Alexane and Forterre, Franck and Olby, Natasha and Gutierrez-Quintana, Rodrigo}, year={2022}, month={Mar} }
 @article{olby_friedenberg_meurs_deprospero_guevar_lau_yost_guo_shelton_2020, title={A mutation in MTM1 causes X-Linked myotubular myopathy in Boykin spaniels}, volume={30}, ISSN={0960-8966}, url={http://dx.doi.org/10.1016/j.nmd.2020.02.021}, DOI={10.1016/j.nmd.2020.02.021}, abstractNote={The purpose of this study was to report the findings of clinical and genetic evaluation of a 3-month old male Boykin spaniel (the proband) that presented with progressive weakness. The puppy underwent a physical and neurological examination, serum biochemistry and complete blood cell count, electrophysiological testing, muscle biopsy and whole genome sequencing. Clinical evaluation revealed generalized neuromuscular weakness with tetraparesis and difficulty holding the head up and a dropped jaw. There was diffuse spontaneous activity on electromyography, most severe in the cervical musculature. Nerve conduction studies were normal, the findings were interpreted as consistent with a myopathy. Skeletal muscle was grossly abnormal on biopsy and there were necklace fibers and abnormal triad structure localization on histopathology, consistent with myotubular myopathy. Whole genome sequencing revealed a premature stop codon in exon 13 of MTM1 (ChrX: 118,903,496 C > T, c.1467C>T, p.Arg512X). The puppy was humanely euthanized at 5 months of age. The puppy's dam was heterozygous for the variant, and 3 male puppies from a subsequent litter all of which died by 2 weeks of age were hemizygous for the variant. This naturally occurring mutation in Boykin spaniels causes a severe form of X-linked myotubular myopathy, comparable to the human counterpart.}, number={5}, journal={Neuromuscular Disorders}, publisher={Elsevier BV}, author={Olby, Natasha J. and Friedenberg, Steven and Meurs, Kathryn and DeProspero, Dylan and Guevar, Julien and Lau, Jeanie and Yost, Oriana and Guo, Ling T. and Shelton, G. Diane}, year={2020}, month={Mar}, pages={353–359} }
 @article{guevar_bleedorn_cullum_hetzel_zlotnick_mariani_2020, title={Accuracy and safety of three-dimensionally printed animal-specific drill guides for thoracolumbar vertebral column instrumentation in dogs: Bilateral and unilateral designs}, ISBN={1532-950X}, DOI={10.1111/vsu.13558}, abstractNote={AbstractObjectiveTo evaluate the safety and accuracy of a unilateral three‐dimensionally printed animal‐specific drill guide (3DASDG) design for unilateral stabilization in the thoracolumbar vertebral column of dogs compared to a bilateral design.Study designCadaveric study.Sample populationFifty‐two corridors in one canine cadaver.MethodsTwo 3DASDG designs with 2 drilling tubes each were created from T8 to L7 vertebrae. Fifty‐two corridors were drilled on the right and the left sides by using unilateral and bilateral designs, respectively. Planned and postoperative trajectories (entry point, exit point, angle) were compared to establish the accuracy. Statistical analysis was used for accuracy comparison between designs. Safety was evaluated by using Zdichavsky classification.ResultsUnilateral and bilateral drill guide designs were not different for entry point and angle deviations; however, they were different for the exit point deviations. Two corridors breached outside the vertebra. For all guides, mean entry and exit point deviations were less than 1 and 2 mm, respectively. The maximum entry or exit point deviation in both groups was 4.7 mm. The mean angle deviation was <3.5°, and the maximum angle deviation was 9.3°.ConclusionNo difference was detected in accuracy of entry points and angle deviations between drill guide designs tested in normal vertebrae. The technique was classified as highly safe.Clinical significanceA unilateral drill guide design may be a safe alternative to bilateral guides for unilateral stabilization of the thoracolumbar vertebral column in dogs.}, journal={VETERINARY SURGERY}, author={Guevar, Julien and Bleedorn, Jason and Cullum, Thomas and Hetzel, Scott and Zlotnick, Josh and Mariani, Christopher L.}, year={2020} }
 @article{mariani_zlotnick_harrysson_marcellin-little_malinak_gavitt_guevar_2021, title={Accuracy of three-dimensionally printed animal-specific drill guides for implant placement in canine thoracic vertebrae: A cadaveric study}, volume={50}, ISSN={["1532-950X"]}, url={https://doi.org/10.1111/vsu.13557}, DOI={10.1111/vsu.13557}, abstractNote={AbstractObjectiveTo assess the accuracy of three‐dimensionally (3‐D) printed drill guides in constraining the trajectory of drill tracts for implants in canine thoracic vertebrae.Study designExperimental ex vivo study.Sample populationFive canine thoracic vertebral column specimens.MethodsGuides to constrain drill trajectories were designed on the basis of computed tomographic (CT) imaging of six thoracic vertebrae (T8‐T13) and were 3‐D printed. The guides were used to create drill tracts in these vertebrae by both an experienced and a novice surgeon, and CT imaging was repeated. The entry point and angulation of actual and planned drill tracts were compared for both surgeons. Unintended cortical violations were also assessed by using a modified Zdichavsky classification.ResultsFifty‐eight drill tracts were created in 30 vertebrae. Mean entry point deviation was 1.4 mm (range, 0.4‐3.4), and mean angular deviation was 5.1° (range, 1.5°‐10.8°). There were no differences between surgeons in entry point deviation (P = .07) or angular deviation (P = .22). There were no unintended cortical bone violations, and all drill tracts were classified as modified Zdichavsky grade I.ConclusionThe 3‐D printed guides used in the current study yielded drill tracts with small linear and angular errors from intended paths and 100% accuracy for placement within vertebral pedicles and bodies. This technique was conveniently used by both an experienced and a novice surgeon.Clinical significanceThis technique might be immediately applicable to clinical cases requiring thoracic vertebral stabilization and may allow safe and accurate implant placement for surgeons with varying experience levels.}, number={2}, journal={VETERINARY SURGERY}, publisher={Wiley}, author={Mariani, Christopher L. and Zlotnick, Joshua A. and Harrysson, Ola and Marcellin-Little, Denis J. and Malinak, Kristen and Gavitt, Ashley and Guevar, Julien}, year={2021}, month={Feb}, pages={294–302} }
 @article{guevar_zidan_durand_olby_2020, title={Minimally invasive spine surgery in dogs: Evaluation of the safety and feasibility of a thoracolumbar approach to the spinal cord}, volume={49}, ISSN={0161-3499 1532-950X}, url={http://dx.doi.org/10.1111/vsu.13385}, DOI={10.1111/vsu.13385}, abstractNote={AbstractObjectiveTo describe the safety and feasibility of a minimally invasive spine surgery technique to access the thoracolumbar vertebral canal in dogs.Study designProspective study.AnimalsSix healthy research dogs.MethodsDogs were placed under anesthesia for MRI to evaluate vertebral column and spinal cord integrity. Minimally invasive surgery was performed at multiple sites. Access to the vertebral canal was achieved by means of foraminotomy, discectomy, and lateral minicorpectomy by using minimally invasive access and a surgical microscope. Sequential neurological examinations, pressure algometry pain quantification, and creatine kinase levels were evaluated before and after surgery for 7 days. Magnetic resonance imaging, computed tomography, and histopathology were performed on day 6 postoperatively after animals were humanely killed to evaluate the impact of surgery on spinal cord, muscles, and bone.ResultsThe vertebral canal was successfully accessed, and the ventral aspect of the spinal cord was identified at all sites. No neurological deterioration was observed. Postoperative pain was not different compared with baseline except in one dog on the day after surgery.ConclusionMinimally invasive spine surgery was a safe and feasible technique to access the thoracolumbar vertebral canal and the ventral aspect of the spinal cord in dogs. Findings supported postoperative pain benefits.Clinical significanceMinimally invasive spine surgery is a valid surgical technique to access the thoracolumbar vertebral canal at single or multiple sites in dogs.}, journal={Veterinary Surgery}, publisher={Wiley}, author={Guevar, Julien and Zidan, Natalia and Durand, Alexane and Olby, Natasha J.}, year={2020}, month={Jan}, pages={O76–O85} }
 @article{amengual-batle_jose-lopez_durand_czopowicz_beltran_guevar_lazzerini_de decker_munana_early_et al._2020, title={Traumatic skull fractures in dogs and cats: A comparative analysis of neurological and computed tomographic features}, volume={34}, ISSN={["1939-1676"]}, DOI={10.1111/jvim.15838}, abstractNote={AbstractBackgroundTraumatic skull fractures (TSF) are relatively frequent in dogs and cats, but little information is available regarding their clinical and imaging features.Hypothesis/ObjectivesTo describe the neurological and computed tomographic (CT) features of a large cohort of dogs and cats with TSF.AnimalsNinety‐one dogs and 95 cats with TSF identified on CT.MethodsMulticenter retrospective comparative study. Signalment, cause of trauma, fracture locations and characteristics, presence of neurological deficits, and 1‐week survival were recorded. Fractures were classified according to the extent of fragmentation and displacement.ResultsThe cranial vault was affected more frequently in dogs (P = .003), whereas the face and base of the cranium more often was affected in cats (P < .001). Cats presented with multiple fractures more frequently (P < .001). All animals with TSF in the cranial vault were more likely to develop neurological signs (P = .02), especially when depressed fractures were present (95% confidence interval [CI], 1.7‐8.2; P = .001). Animals with TSF located only in the facial region were less likely to have neurological signs (odds ratio with Mantel‐Haenszel's method [ORMH], 0.2; 95% CI, 0.1‐0.6; P = .004). Most affected animals (84.9%) survived the first week post‐trauma. Death was more likely with fractures of the cranial vault (P = .003), especially when fragmented (P = .007) and displaced (P = .004).Conclusions and Clinical ImportanceTraumatic skull fracture distribution and patterns are different between dogs and cats. Cranial vault fractures were associated with neurological deficits and worse survival. The presence of TSF alone should not be considered a negative prognostic factor because most affected animals survived the first week.}, number={5}, journal={JOURNAL OF VETERINARY INTERNAL MEDICINE}, author={Amengual-Batle, Pablo and Jose-Lopez, Roberto and Durand, Alexane and Czopowicz, Michal and Beltran, Elsa and Guevar, Julien and Lazzerini, Kali and De Decker, Steven and Munana, Karen and Early, Peter and et al.}, year={2020}, month={Sep}, pages={1975–1985} }
 @article{guevar_olby_2020, title={Minimally invasive microsurgical decompression of an intervertebral disc protrusion in a dog}, volume={49}, ISSN={["1532-950X"]}, url={https://doi.org/10.1111/vsu.13263}, DOI={10.1111/vsu.13263}, abstractNote={AbstractObjectiveTo report the successful treatment of intervertebral disc protrusion with minimally invasive microsurgery in a large breed dog.Study designRetrospective case report.AnimalA 4‐year‐old, neutered male, German shepherd dog presented with chronic progressive ambulatory paraparesis and thoracolumbar pain; lumbar intervertebral disc protrusion and severe spinal cord compression at L2‐L3 were diagnosed.MethodsA minimally invasive approach was used to access the target surgical area by using a muscle splitting technique and retractors. Intraoperative fluoroscopy confirmed correct placement. Magnification and illumination through a surgical microscope were used (microsurgery) to perform the spinal cord decompression by means of a foraminotomy and lateral corpectomy.ResultsTechnically, the combination of fluoroscopy and muscle splitting approach offered adequate minimally invasive access. Microsurgery allowed for precise and efficient spinal cord decompression. Clinically, no immediate postoperative neurological deterioration was observed. Opioid usage was limited to 24 hours postoperatively. Focal muscle swelling was observed postoperatively for 2 days, and hospital stay was 3 days. At 7 weeks postoperatively, neurological examination results were normal, and postoperative MRI confirmed spinal cord decompression. No complications were reported.ConclusionThe procedure was associated with a small incision, limited muscle trauma, early improvement of the neurological status, a short hospital stay, and limited postoperative pain.Clinical significanceThis case provides evidence that minimally invasive microsurgery is an effective treatment for intervertebral disc protrusion in large breed dogs and may offer benefits regarding postoperative pain and functional recovery.}, journal={VETERINARY SURGERY}, author={Guevar, Julien and Olby, Natasha}, year={2020}, month={Jun}, pages={O86–O92} }
 @article{zidan_sims_fenn_williams_griffith_early_mariani_munana_guevar_olby_et al._2018, title={A randomized, blinded, prospective clinical trial of postoperative rehabilitation in dogs after surgical decompression of acute thoracolumbar intervertebral disc herniation}, volume={32}, ISSN={0891-6640}, url={http://dx.doi.org/10.1111/jvim.15086}, DOI={10.1111/jvim.15086}, abstractNote={BackgroundExperimental evidence shows benefit of rehabilitation after spinal cord injury (SCI) but there are limited objective data on the effect of rehabilitation on recovery of dogs after surgery for acute thoracolumbar intervertebral disc herniations (TL‐IVDH).ObjectiveCompare the effect of basic and intensive post‐operative rehabilitation programs on recovery of locomotion in dogs with acute TL‐IVDH in a randomized, blinded, prospective clinical trial.AnimalsThirty non‐ambulatory paraparetic or paraplegic (with pain perception) dogs after decompressive surgery for TL‐IVDH.MethodsBlinded, prospective clinical trial. Dogs were randomized (1:1) to a basic or intensive 14‐day in‐house rehabilitation protocol. Fourteen‐day open field gait score (OFS) and coordination (regulatory index, RI) were primary outcomes. Secondary measures of gait, post‐operative pain, and weight were compared at 14 and 42 days.ResultsOf 50 dogs assessed, 32 met inclusion criteria and 30 completed the protocol. There were no adverse events associated with rehabilitation. Median time to walking was 7.5 (2 – 37) days. Mean change in OFS by day 14 was 6.13 (confidence intervals: 4.88, 7.39, basic) versus 5.73 (4.94, 6.53, intensive) representing a treatment effect of −0.4 (−1.82, 1.02) which was not significant, P=.57. RI on day 14 was 55.13 (36.88, 73.38, basic) versus 51.65 (30.98, 72.33, intensive), a non‐significant treatment effect of −3.47 (−29.81, 22.87), P = .79. There were no differences in secondary outcomes between groups.ConclusionsEarly postoperative rehabilitation after surgery for TL‐IVDH is safe but doesn't improve rate or level of recovery in dogs with incomplete SCI.}, number={3}, journal={Journal of Veterinary Internal Medicine}, publisher={Wiley}, author={Zidan, Natalia and Sims, Cory and Fenn, Joe and Williams, Kim and Griffith, Emily and Early, Peter J. and Mariani, Chris L. and Munana, Karen and Guevar, Julien and Olby, Natasha J. and et al.}, year={2018}, month={Apr}, pages={1133–1144} }
 @article{guevar_olby_meurs_yost_friedenberg_2018, title={Deafness and vestibular dysfunction in a Doberman Pinscher puppy associated with a mutation in the PTPRQ
 gene}, volume={32}, ISSN={0891-6640}, url={http://dx.doi.org/10.1111/jvim.15060}, DOI={10.1111/jvim.15060}, abstractNote={BackgroundA congenital syndrome of hearing loss and vestibular dysfunction affects Doberman Pinschers. Its inheritance pattern is suspected to be autosomal recessive and it potentially represents a spontaneous animal model of an autosomal recessive syndromic hearing loss.Hypothesis/ObjectivesThe objectives of this study were to use whole genome sequencing (WGS) to identify deleterious genetic variants in candidate genes associated with the syndrome and to study the prevalence of candidate variants among a population of unaffected Doberman Pinschers.AnimalsOne affected Doberman Pinscher and 202 unaffected Doberman Pinschers.MethodsWGS of the affected dog with filtering of variants against a database of 154 unaffected dogs of diverse breeds was performed. Confirmation of candidate variants was achieved by Sanger sequencing followed by genotyping of the control population of unaffected Doberman Pinschers.ResultsWGS and variant filtering identified an alteration in a gene associated with both deafness and vestibular disease in humans: protein tyrosine phosphatase, receptor type Q (PTPRQ). There was a homozygous A insertion at CFA15: 22 989 894, causing a frameshift mutation in exon 39 of the gene. This insertion is predicted to cause a protein truncation with a premature stop codon occurring after position 2054 of the protein sequence that causes 279 C‐terminal amino acids to be eliminated. Prevalence of the variant was 1.5% in a cohort of 202 unaffected Doberman Pinschers; all unaffected Doberman Pinschers were heterozygous or heterozygous for the reference allele.Conclusion and Clinical ImportanceWe report the identification of a genetic alteration on the PTPRQ gene that is associated with congenital hearing and vestibular disorder in a young Doberman Pinscher dog.}, number={2}, journal={Journal of Veterinary Internal Medicine}, publisher={Wiley}, author={Guevar, Julien and Olby, Natasha J. and Meurs, Kathryn M. and Yost, Oriana and Friedenberg, Steven G.}, year={2018}, month={Feb}, pages={665–669} }
 @article{christ_guevar_poyade_rea_2018, title={Proof of concept of a workflow methodology for the creation of basic canine head anatomy veterinary education tool using augmented reality}, volume={13}, ISSN={["1932-6203"]}, DOI={10.1371/journal.pone.0195866}, abstractNote={Neuroanatomy can be challenging to both teach and learn within the undergraduate veterinary medicine and surgery curriculum. Traditional techniques have been used for many years, but there has now been a progression to move towards alternative digital models and interactive 3D models to engage the learner. However, digital innovations in the curriculum have typically involved the medical curriculum rather than the veterinary curriculum. Therefore, we aimed to create a simple workflow methodology to highlight the simplicity there is in creating a mobile augmented reality application of basic canine head anatomy. Using canine CT and MRI scans and widely available software programs, we demonstrate how to create an interactive model of head anatomy. This was applied to augmented reality for a popular Android mobile device to demonstrate the user-friendly interface. Here we present the processes, challenges and resolutions for the creation of a highly accurate, data based anatomical model that could potentially be used in the veterinary curriculum. This proof of concept study provides an excellent framework for the creation of augmented reality training products for veterinary education. The lack of similar resources within this field provides the ideal platform to extend this into other areas of veterinary education and beyond.}, number={4}, journal={PLOS ONE}, author={Christ, Roxie and Guevar, Julien and Poyade, Matthieu and Rea, Paul M.}, year={2018}, month={Apr} }
 @article{zidan_fenn_griffith_early_mariani_muñana_guevar_olby_2018, title={The Effect of Electromagnetic Fields on Post-Operative Pain and Locomotor Recovery in Dogs with Acute, Severe Thoracolumbar Intervertebral Disc Extrusion: A Randomized Placebo-Controlled, Prospective Clinical Trial}, volume={35}, ISSN={0897-7151 1557-9042}, url={http://dx.doi.org/10.1089/neu.2017.5485}, DOI={10.1089/neu.2017.5485}, abstractNote={Spinal cord injury (SCI) attributed to acute intervertebral disc extrusions (IVDEs) is common in dogs and is treated by surgical decompression. Dogs with sensorimotor complete injuries have an incomplete recovery. Pulsed electromagnetic fields (PEMFs) reduce post-operative pain through anti-inflammatory effects and there is growing evidence for neuroprotective effects. This randomized, controlled clinical trial evaluated the effect of PEMF on post-operative pain and neurological recovery in dogs with surgically treated sensorimotor complete SCI attributed to acute IVDE. Sixteen dogs with surgically treated complete thoracolumbar SCI were randomized to receive PEMF (15 min every 2 h for 2 weeks then twice-daily for 4 weeks) or placebo starting immediately after diagnosis. The primary outcome was gait score at 2 weeks. Secondary measures of gait, pain perception, and proprioceptive function were evaluated at 2 and 6 weeks. Plasma glial fibrillary acidic protein (GFAP) concentration was measured as an SCI biomarker. Post-operative pain was quantified by measuring mechanical sensory thresholds (MSTs) at control and surgical sites. There was no significant difference in demographics or GFAP concentration between the two groups at trial entry. There was no difference in primary outcome or in secondary measures of gait, but proprioceptive placing was significantly better at 6 weeks and GFAP concentrations were significantly lower at 2 weeks in the PEMF group. MSTs were significantly higher in the PEMF-treated group. We conclude that PEMF reduced incision-associated pain in dogs post-surgery for IVDE and may reduce extent of SCI and enhance proprioceptive placing. Larger clinical trials are warranted.}, number={15}, journal={Journal of Neurotrauma}, publisher={Mary Ann Liebert Inc}, author={Zidan, Natalia and Fenn, Joe and Griffith, Emily and Early, Peter J. and Mariani, Chris L. and Muñana, Karen R. and Guevar, Julien and Olby, Natasha J.}, year={2018}, month={Aug}, pages={1726–1736} }
 @article{rodino-tilve_guevar_hammond_penderis_2017, title={Incomplete ossification of the atlas in a dog: surgical stabilisation using a SOP plate}, volume={58}, ISSN={["1748-5827"]}, DOI={10.1111/jsap.12664}, abstractNote={Journal of Small Animal PracticeVolume 58, Issue 5 p. 301-301 IMAGES IN SMALL ANIMAL PRACTICE Incomplete ossification of the atlas in a dog: surgical stabilisation using a SOP plate V. Rodiño-Tilve, V. Rodiño-Tilve School of Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Bearsden, Glasgow, G61 1QH, UKSearch for more papers by this authorJ. Guevar, Corresponding Author J. Guevar Julien.guevar@gmail.com Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, NC, 27607 USACorresponding author email: Julien.guevar@gmail.comSearch for more papers by this authorG. Hammond, G. Hammond School of Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Bearsden, Glasgow, G61 1QH, UKSearch for more papers by this authorJ. Penderis, J. Penderis Vet Extra Neurology, Broadleys Veterinary Hospital, Craig Leith Road, Broadleys, Stirling, FK7 7LE UKSearch for more papers by this author V. Rodiño-Tilve, V. Rodiño-Tilve School of Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Bearsden, Glasgow, G61 1QH, UKSearch for more papers by this authorJ. Guevar, Corresponding Author J. Guevar Julien.guevar@gmail.com Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, NC, 27607 USACorresponding author email: Julien.guevar@gmail.comSearch for more papers by this authorG. Hammond, G. Hammond School of Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Bearsden, Glasgow, G61 1QH, UKSearch for more papers by this authorJ. Penderis, J. Penderis Vet Extra Neurology, Broadleys Veterinary Hospital, Craig Leith Road, Broadleys, Stirling, FK7 7LE UKSearch for more papers by this author First published: 24 March 2017 https://doi.org/10.1111/jsap.12664Citations: 1Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article.Citing Literature Volume58, Issue5May 2017Pages 301-301 RelatedInformation}, number={5}, journal={JOURNAL OF SMALL ANIMAL PRACTICE}, author={Rodino-Tilve, V. and Guevar, J. and Hammond, G. and Penderis, J.}, year={2017}, month={May}, pages={301–301} }
 @article{giles_orr_viora_gutierrez-quintana_logue_guevar_2017, title={Ruminant neurological disease: a retrospective cohort study}, volume={181}, ISSN={["2042-7670"]}, DOI={10.1136/vr.104326}, abstractNote={Between January 2006 and June 2016, 96 ruminants with neurological signs were donated to the Scottish Centre for Production Animal Health and Food Safety (SCPAHFS), University of Glasgow, by veterinarians in the field representing 5.4 per cent of all submissions. Forty‐seven different neurological presenting signs were reported with 79 per cent of the donated patients presenting with abnormal gait. All cases presenting with abnormalities in more than 4 out of 10 neurological categories died or were euthanased on welfare grounds. Calves were significantly more likely to present with neurological disorders than adult cattle compared with the proportion of calves: cows in the Scottish cattle population and total case population donated to SCPAHFS. Lesions were most commonly localised to the spinal cord in sheep 47 per cent (16), the peripheral nervous system in cattle 45 per cent (28) and to the brain in the overall population 41 per cent (39). The most common aetiology of neurological pathologies observed was infectious or inflammatory 28 per cent (27). Definitive diagnoses could be reached in 84 per cent (81) of patients. When postmortem reports were available, they produced a diagnosis in 70 per cent (52) of cases and contradicted clinical diagnoses in 38 per cent (26) of cases. The most frequently diagnosed conditions in ruminants over the 10 years were spastic paresis, vertebral osteomyelitis and listeriosis.}, number={14}, journal={VETERINARY RECORD}, author={Giles, Lucy and Orr, Jayne and Viora, Lorenzo and Gutierrez-Quintana, Rodrigo and Logue, David and Guevar, Julien}, year={2017}, month={Oct} }