Works (1)
Updated: July 5th, 2023 15:55
2006 journal article
Evaluation of glycosaminoglycans content and 5-hydroxytryptamine 2B receptor in the heart valves of Sprague-Dawley rats with spontaneous mitral valvulopathy - A possible exacerbation by dl-amphetamine sulfate in Fischer 344 rats?
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, 58(2-3), 89–99.
author keywords: mitral valve; valvulopathy; 5-hydroxytryptamine 2B receptor; anorexigens; dl-amphetamine; quantitative image analysis; Sprague-Dawley rats; Fischer 344 rats
MeSH headings : Aging / pathology; Amphetamine / toxicity; Animals; Female; Glycosaminoglycans / analysis; Male; Mitral Valve / chemistry; Mitral Valve / drug effects; Mitral Valve / pathology; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2B / analysis
TL;DR:
Examination of 5-hydroxytryptamine 2B receptor expression and characterization of extracellular matrix (ECM) components and the presence of valvulopathy in the mitral valve-leaflet of Sprague-Dawley (SD) rats suggested a role for 5HT2BR in the pathogenesis of SMV in SD rats, but additional research is needed to confirm this.
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3. Good Health and Well-being
(Web of Science; OpenAlex)
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Added: August 6, 2018
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