Works (6)
Updated: July 8th, 2023 21:16
2010 journal article
Evaluation of the relationship between lesions in the gastroduodenal region and cyclooxygenase expression in clinically normal dogs
American Journal of Veterinary Research, 71(6), 630–635.
Contributors: n, B. Lascelles n, V. Cook*, J. Law n & A. Blikslager n
MeSH headings : Animals; Blotting, Western / veterinary; Cyclooxygenase 1 / biosynthesis; Cyclooxygenase 2 / biosynthesis; Dog Diseases / enzymology; Dog Diseases / pathology; Dogs / metabolism; Duodenitis / enzymology; Duodenitis / pathology; Duodenitis / veterinary; Duodenum / enzymology; Duodenum / pathology; Female; Gastritis / enzymology; Gastritis / pathology; Gastritis / veterinary; Immunohistochemistry / veterinary; Intestinal Mucosa / enzymology; Intestinal Mucosa / pathology; Male; Pylorus / enzymology; Pylorus / pathology; Statistics, Nonparametric
TL;DR:
Dogs that appear to be clinically normal may have underlying gastroduodenal lesions associated with upregulation of COX-2, and practitioners should be aware of this potential situation when prescribing COX inhibitors.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2009 journal article
Effect of nonsteroidal anti-inflammatory drugs with varied cyclooxygenase-2 selectivity on cyclooxygenase protein and prostanoid concentrations in pyloric and duodenal mucosa of dogs
American Journal of Veterinary Research, 70(10), 1243–1249.
Contributors: n, A. Blikslager n , S. Marks n, J. Law n, E. Graeber n & B. Lascelles n
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / pharmacology; Dogs; Drug Administration Schedule; Female; Gastric Mucosa / drug effects; Gastric Mucosa / metabolism; Gene Expression Regulation / drug effects; Male; Prostaglandin-Endoperoxide Synthases / metabolism; Prostaglandins / metabolism
TL;DR:
It is suggested that, for these experimental conditions, there were no differences among the preferential and selective COX-2 inhibitors with regard to adverse effects on the gastric and duodenal portions of the gastrointestinal tract of dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2008 journal article
Cyclooxygenase expression and prostanoid production in pyloric and duodenal mucosae in dogs after administration of nonsteroidal anti-inflammatory drugs
American Journal of Veterinary Research, 69(4), 457–464.
Contributors: n, A. Blikslager* , K. Ryan*, S. Marks*, J. Law* & B. Lascelles
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / pharmacology; Biopsy / veterinary; Blotting, Western / veterinary; Cross-Over Studies; Cyclooxygenase 1 / biosynthesis; Cyclooxygenase 2 / biosynthesis; Dogs / metabolism; Endoscopy / veterinary; Female; Gastric Mucosa / drug effects; Gastric Mucosa / enzymology; Gastric Mucosa / metabolism; Histocytochemistry / veterinary; Intestinal Mucosa / drug effects; Intestinal Mucosa / enzymology; Intestinal Mucosa / metabolism; Male; Prostaglandins / biosynthesis; Pyloric Antrum / drug effects; Pyloric Antrum / enzymology; Pyloric Antrum / metabolism; Random Allocation; Thromboxane B2 / metabolism
TL;DR:
In dogs, prostanoid synthesis was greater in pyloric mucosa than it was in duodenal mucosa, compared with the effects of a selective COX-2 NSAID.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2006 journal article
Cyclooxygenase expression in the early stages of equine laminitis: A cytologic study
Journal of Veterinary Internal Medicine, 20(5), 1191–1196.
TL;DR:
COX-2 protein expression is markedly increased in the resident laminar cell types in the developmental stage of BWE-induced laminitis, although a lesser increase was observed in the LAM group.
(via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2006 journal article
Prostaglandin-mediated inhibition of Na+/H+ exchanger isoform 2 stimulates recovery of barrier function in ischemia-injured intestine
American Journal of Physiology-Gastrointestinal and Liver Physiology, 291(5), G885–G894.
Contributors: A. Moeser n, P. Nighot*, K. Ryan*, * & A. Blikslager*
author keywords: tight junction; restitution; Na+/H+ exchange
MeSH headings : Animals; Blotting, Western; Diffusion Chambers, Culture; Electric Impedance; Electrophoresis, Polyacrylamide Gel; Female; Guanidines / pharmacology; Ileum / blood supply; Ileum / metabolism; Immunohistochemistry; Immunoprecipitation; Intestinal Absorption / drug effects; Intestinal Absorption / physiology; Intestinal Mucosa / blood supply; Intestinal Mucosa / metabolism; Intestines / blood supply; Intestines / pathology; Ischemia / pathology; Male; Methacrylates / pharmacology; Prostaglandins / pharmacology; Regional Blood Flow / drug effects; Regional Blood Flow / physiology; Sodium / metabolism; Sodium-Hydrogen Exchangers / antagonists & inhibitors; Sulfones / pharmacology; Swine
TL;DR:
Selective inhibition of NHE2, and not NHE3, induces recovery of barrier function in the ischemia-injured intestine.
(via Semantic Scholar)
open access via ajpgi.physiology.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2006 journal article
Stress signaling pathways activated by weaning mediate intestinal dysfunction in the pig
American Journal of Physiology-Gastrointestinal and Liver Physiology, 292(1), G173–G181.
Contributors: A. Moeser n, C. Klok n, K. Ryan n, n, D. Little n, V. Cook n, A. Blikslager n
author keywords: barrier function; secretion
MeSH headings : Animals; Colon / physiopathology; Disease Models, Animal; Female; Jejunum / physiopathology; Male; Maternal Behavior; Muscle, Smooth / physiopathology; Signal Transduction; Stress, Psychological / physiopathology; Swine; Weaning
TL;DR:
The results indicate that weaning stress induces mucosal dysfunction mediated by intestinal CRF receptors and activated by enteric nerves and prostanoid pathways.
(via Semantic Scholar)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
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