Jenna Gray Wooten

Works (6)

Updated: July 8th, 2023 21:16

2010 journal article

Evaluation of the relationship between lesions in the gastroduodenal region and cyclooxygenase expression in clinically normal dogs

American Journal of Veterinary Research, 71(6), 630–635.

By: J. Wooten n, B. Lascelles n , V. Cook*, J. Law n & A. Blikslager n 

Contributors: J. Wooten n, B. Lascelles n , V. Cook*, J. Law n & A. Blikslager n 

MeSH headings : Animals; Blotting, Western / veterinary; Cyclooxygenase 1 / biosynthesis; Cyclooxygenase 2 / biosynthesis; Dog Diseases / enzymology; Dog Diseases / pathology; Dogs / metabolism; Duodenitis / enzymology; Duodenitis / pathology; Duodenitis / veterinary; Duodenum / enzymology; Duodenum / pathology; Female; Gastritis / enzymology; Gastritis / pathology; Gastritis / veterinary; Immunohistochemistry / veterinary; Intestinal Mucosa / enzymology; Intestinal Mucosa / pathology; Male; Pylorus / enzymology; Pylorus / pathology; Statistics, Nonparametric
topics (OpenAlex): Inflammatory mediators and NSAID effects; Veterinary Oncology Research; Cancer, Stress, Anesthesia, and Immune Response
TL;DR: Dogs that appear to be clinically normal may have underlying gastroduodenal lesions associated with upregulation of COX-2, and practitioners should be aware of this potential situation when prescribing COX inhibitors. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2009 journal article

Effect of nonsteroidal anti-inflammatory drugs with varied cyclooxygenase-2 selectivity on cyclooxygenase protein and prostanoid concentrations in pyloric and duodenal mucosa of dogs

American Journal of Veterinary Research, 70(10), 1243–1249.

By: J. Wooten n, A. Blikslager n , S. Marks n, J. Law n, E. Graeber n & B. Lascelles n 

Contributors: J. Wooten n, A. Blikslager n , S. Marks n, J. Law n, E. Graeber n & B. Lascelles n 

MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / pharmacology; Dogs; Drug Administration Schedule; Female; Gastric Mucosa / drug effects; Gastric Mucosa / metabolism; Gene Expression Regulation / drug effects; Male; Prostaglandin-Endoperoxide Synthases / metabolism; Prostaglandins / metabolism
topics (OpenAlex): Inflammatory mediators and NSAID effects; Estrogen and related hormone effects; Helicobacter pylori-related gastroenterology studies
TL;DR: It is suggested that, for these experimental conditions, there were no differences among the preferential and selective COX-2 inhibitors with regard to adverse effects on the gastric and duodenal portions of the gastrointestinal tract of dogs. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2008 journal article

Cyclooxygenase expression and prostanoid production in pyloric and duodenal mucosae in dogs after administration of nonsteroidal anti-inflammatory drugs

American Journal of Veterinary Research, 69(4), 457–464.

By: J. Wooten*, A. Blikslager n , K. Ryan n, S. Marks n, J. Law n & B. Lascelles n 

Contributors: J. Wooten*, A. Blikslager n , K. Ryan n, S. Marks n, J. Law n & B. Lascelles n 

MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / pharmacology; Biopsy / veterinary; Blotting, Western / veterinary; Cross-Over Studies; Cyclooxygenase 1 / biosynthesis; Cyclooxygenase 2 / biosynthesis; Dogs / metabolism; Endoscopy / veterinary; Female; Gastric Mucosa / drug effects; Gastric Mucosa / enzymology; Gastric Mucosa / metabolism; Histocytochemistry / veterinary; Intestinal Mucosa / drug effects; Intestinal Mucosa / enzymology; Intestinal Mucosa / metabolism; Male; Prostaglandins / biosynthesis; Pyloric Antrum / drug effects; Pyloric Antrum / enzymology; Pyloric Antrum / metabolism; Random Allocation; Thromboxane B2 / metabolism
topics (OpenAlex): Inflammatory mediators and NSAID effects; Neuropeptides and Animal Physiology; Estrogen and related hormone effects
TL;DR: In dogs, prostanoid synthesis was greater in pyloric mucosa than it was in duodenal mucosa, compared with the effects of a selective COX-2 NSAID. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2006 article

Cyclooxygenase Expression in the Early Stages of Equine Laminitis: A Cytologic Study

Blikslager, A. T., Yin, C., Cochran, A. M., Wooten, J. G., Pettigrew, A., & Belknap, J. K. (2006, September 1). Journal of Veterinary Internal Medicine, Vol. 20, pp. 1191–1196.

By: A. Blikslager n , C. Yin*, A. Cochran*, J. Wooten n, A. Pettigrew* & J. Belknap *

topics (OpenAlex): Veterinary Equine Medical Research; Inflammatory mediators and NSAID effects; Veterinary medicine and infectious diseases
TL;DR: COX-2 protein expression is markedly increased in the resident laminar cell types in the developmental stage of BWE-induced laminitis, although a lesser increase was observed in the LAM group. (via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2006 journal article

Prostaglandin-mediated inhibition of Na+/H+ exchanger isoform 2 stimulates recovery of barrier function in ischemia-injured intestine

American Journal of Physiology-Gastrointestinal and Liver Physiology, 291(5), G885–G894.

By: A. Moeser n, P. Nighot*, K. Ryan*, J. Wooten* & A. Blikslager* 

Contributors: A. Moeser n, P. Nighot*, K. Ryan*, J. Wooten* & A. Blikslager* 

author keywords: tight junction; restitution; Na+/H+ exchange
MeSH headings : Animals; Blotting, Western; Diffusion Chambers, Culture; Electric Impedance; Electrophoresis, Polyacrylamide Gel; Female; Guanidines / pharmacology; Ileum / blood supply; Ileum / metabolism; Immunohistochemistry; Immunoprecipitation; Intestinal Absorption / drug effects; Intestinal Absorption / physiology; Intestinal Mucosa / blood supply; Intestinal Mucosa / metabolism; Intestines / blood supply; Intestines / pathology; Ischemia / pathology; Male; Methacrylates / pharmacology; Prostaglandins / pharmacology; Regional Blood Flow / drug effects; Regional Blood Flow / physiology; Sodium / metabolism; Sodium-Hydrogen Exchangers / antagonists & inhibitors; Sulfones / pharmacology; Swine
topics (OpenAlex): Ion Transport and Channel Regulation; Gastrointestinal motility and disorders; Ion channel regulation and function
TL;DR: Selective inhibition of NHE2, and not NHE3, induces recovery of barrier function in the ischemia-injured intestine. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2006 journal article

Stress signaling pathways activated by weaning mediate intestinal dysfunction in the pig

American Journal of Physiology-Gastrointestinal and Liver Physiology, 292(1), G173–G181.

By: A. Moeser*, C. Klok n, K. Ryan n, J. Wooten n, D. Little n, V. Cook n, A. Blikslager n 

Contributors: A. Moeser*, C. Klok n, K. Ryan n, J. Wooten n, D. Little n, V. Cook n, A. Blikslager n 

author keywords: barrier function; secretion
MeSH headings : Animals; Colon / physiopathology; Disease Models, Animal; Female; Jejunum / physiopathology; Male; Maternal Behavior; Muscle, Smooth / physiopathology; Signal Transduction; Stress, Psychological / physiopathology; Swine; Weaning
topics (OpenAlex): Gastrointestinal motility and disorders; Diet and metabolism studies; Stress Responses and Cortisol
TL;DR: The results indicate that weaning stress induces mucosal dysfunction mediated by intestinal CRF receptors and activated by enteric nerves and prostanoid pathways. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

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