@article{vidal_sosnowski_marchesoni_grenier_thorp_murphy_johnson_schlief_hoyo_2024, title={Maternal adverse childhood experiences (ACEs) and offspring imprinted gene DMR methylation at birth}, volume={19}, ISSN={["1559-2308"]}, DOI={10.1080/15592294.2023.2293412}, abstractNote={ABSTRACT Adverse childhood experiences (ACEs) contribute to numerous negative health outcomes across the life course and across generations. Here, we extend prior work by examining the association of maternal ACEs, and their interaction with financial stress and discrimination, with methylation status within eight differentially methylated regions (DMRs) in imprinted domains in newborns. ACEs, financial stress during pregnancy, and experience of discrimination were self-reported among 232 pregnant women. DNA methylation was assessed at PEG10/SGCE, NNAT, IGF2, H19, PLAGL1, PEG3, MEG3-IG, and DLK1/MEG3 regulatory sequences using pyrosequencing. Using multivariable linear regression models, we found evidence to suggest that financial stress was associated with hypermethylation of MEG3-IG in non-Hispanic White newborns; discrimination was associated with hypermethylation of IGF2 and NNAT in Hispanic newborns, and with hypomethylation of PEG3 in non-Hispanic Black newborns. We also found evidence that maternal ACEs interacted with discrimination to predict offspring PLAGL1 altered DMR methylation, in addition to interactions between maternal ACEs score and discrimination predicting H19 and SGCE/PEG10 altered methylation in non-Hispanic White newborns. However, these interactions were not statistically significant after multiple testing corrections. Findings from this study suggest that maternal ACEs, discrimination, and financial stress are associated with newborn aberrant methylation in imprinted gene regions.}, number={1}, journal={EPIGENETICS}, author={Vidal, Adriana C. and Sosnowski, David W. and Marchesoni, Joddy and Grenier, Carole and Thorp, John and Murphy, Susan K. and Johnson, Sara B. and Schlief, Billy and Hoyo, Cathrine}, year={2024}, month={Dec} }
 @article{marchesoni_freeman_tezbasaran_ricci_2024, title={The student staffing advantage: Data Science Consulting Service at NC State University Libraries}, volume={13}, ISSN={["2049-1573"]}, url={https://doi.org/10.1002/sta4.702}, DOI={10.1002/sta4.702}, abstractNote={Abstract The primarily peer‐to‐peer, graduate student‐staffed Data Science Consulting Service at NC State University Libraries, within the Data & Visualization Services (DVS) department and collaborating closely with the Data Science Academy (DSA), has established a sustainable service and staffing model focused on providing broad data science analytic support to researchers across the university community. The service addresses the needs of university researchers who possess domain knowledge in their fields of study but a skills gap in the data science competencies required for research. The literature shows that it has been difficult for libraries to cover these needs with existing staffing models. Few universities follow the model practiced at NC State University, so a scan of the current landscape of data science consulting at universities across the country was performed to establish context. The support model and its advantages are described, including partnership with the DSA, student success, model sustainability and future directions for the service. Through a summary of the DVS assessment and needs evaluation process, the service's advantages in staying ahead of patron needs are illustrated. This scalable, sustainable, student‐focused model could be implemented by similar research institutions to expand the capacity of their technical research services.}, number={2}, journal={STAT}, author={Marchesoni, Joddy and Freeman, Kate and Tezbasaran, Alp and Ricci, Shannon W.}, year={2024}, month={Jun} }
 @article{vidal_chandramouli_marchesoni_brown_liu_murphy_maguire_wang_abdelmalek_mavis_et al._2023, title={<i>AHRR</i> Hypomethylation mediates the association between maternal smoking and metabolic profiles in children}, volume={7}, ISSN={["2471-254X"]}, DOI={10.1097/HC9.0000000000000243}, abstractNote={
            Background:
            Tobacco smoking during pregnancy is associated with metabolic dysfunction in children, but mechanistic insights remain limited. Hypomethylation of cg05575921 in the aryl hydrocarbon receptor repressor (AHRR) gene is associated with in utero tobacco smoke exposure. In this study, we evaluated whether AHRR hypomethylation mediates the association between maternal smoking and metabolic dysfunction in children.
          }, number={10}, journal={HEPATOLOGY COMMUNICATIONS}, author={Vidal, Adriana C. and Chandramouli, Shivram A. and Marchesoni, Joddy and Brown, Nia and Liu, Yukun and Murphy, Susan K. and Maguire, Rachel and Wang, Yaxu and Abdelmalek, Manal F. and Mavis, Alisha M. and et al.}, year={2023}, month={Oct} }
 @article{sosnowski_ellison-barnes_kaufman_hoyo_murphy_hernandez_marchesoni_klein_johnson_2023, title={Financial stress as a mediator of the association between maternal childhood adversity and infant birth weight, gestational age, and NICU admission}, volume={23}, ISSN={["1471-2458"]}, DOI={10.1186/s12889-023-15495-0}, abstractNote={Abstract}, number={1}, journal={BMC PUBLIC HEALTH}, author={Sosnowski, David W. W. and Ellison-Barnes, Alejandra and Kaufman, Joan and Hoyo, Cathrine and Murphy, Susan K. K. and Hernandez, Raquel G. G. and Marchesoni, Joddy and Klein, Lauren M. M. and Johnson, Sara B.}, year={2023}, month={Mar} }
 @article{sosnowski_ellison-barnes_kaufman_hoyo_murphy_hernandez_marchesoni_klein_johnson_2023, title={Financial stress as a mediator of the association between maternal childhood adversity and infant birth weight, gestational age, and NICU admission (vol 23, 606, 2023)}, volume={23}, ISSN={["1471-2458"]}, DOI={10.1186/s12889-023-15783-9}, number={1}, journal={BMC PUBLIC HEALTH}, author={Sosnowski, David W. and Ellison-Barnes, Alejandra and Kaufman, Joan and Hoyo, Cathrine and Murphy, Susan K. and Hernandez, Raquel G. and Marchesoni, Joddy and Klein, Lauren M. and Johnson, Sara B.}, year={2023}, month={May} }
 @article{gonzalez-nahm_marchesoni_maity_maguire_house_tucker_atkinson_murphy_hoyo_2022, title={Maternal Mediterranean Diet Adherence and Its Associations with Maternal Prenatal Stressors and Child Growth}, volume={6}, ISSN={["2475-2991"]}, DOI={10.1093/cdn/nzac146}, abstractNote={ABSTRACT Background Psychosocial and physiologic stressors, such as depression and obesity, during pregnancy can have negative consequences, such as increased systemic inflammation, contributing to chronic disease for both mothers and their unborn children. These conditions disproportionately affect racial/ethnic minorities. The effects of recommended dietary patterns in mitigating the effects of these stressors remain understudied. Objectives We aimed to evaluate the relations between maternal Mediterranean diet adherence (MDA) and maternal and offspring outcomes during the first decade of life in African Americans, Hispanics, and Whites. Methods This study included 929 mother–child dyads from the NEST (Newborn Epigenetics STudy), a prospective cohort study. FFQs were used to estimate MDA in pregnant women. Weight and height were measured in children between birth and age 8 y. Multivariable linear regression models were used to examine associations between maternal MDA, inflammatory cytokines, and pregnancy and postnatal outcomes. Results More than 55% of White women reported high MDA during the periconceptional period compared with 22% of Hispanic and 18% of African American women (P < 0.05). Higher MDA was associated with lower likelihood of depressive mood (β = −0.45; 95% CI: −0.90, −0.18; P = 0.02) and prepregnancy obesity (β = −0.29; 95% CI: −0.57, −0.0002; P = 0.05). Higher MDA was also associated with lower body size at birth, which was maintained to ages 3–5 and 6–8 y—this association was most apparent in White children (3–5 y: β = −2.9, P = 0.02; 6–8 y: β = −3.99, P = 0.01). Conclusions If replicated in larger studies, our data suggest that MDA provides a potent avenue by which effects of prenatal stressors on maternal and fetal outcomes can be mitigated to reduce ethnic disparities in childhood obesity.}, number={11}, journal={CURRENT DEVELOPMENTS IN NUTRITION}, author={Gonzalez-Nahm, Sarah and Marchesoni, Joddy and Maity, Arnab and Maguire, Rachel L. and House, John S. and Tucker, Rachel and Atkinson, Tamara and Murphy, Susan K. and Hoyo, Cathrine}, year={2022}, month={Nov} }