Joe Barycki

Works (21)

Updated: July 9th, 2023 21:18
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2022 review

Mechanisms of coordinating hyaluronan and glycosaminoglycan production by nucleotide sugars

[Review of ]. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 322(6), C1201–C1213.

By: B. Zimmer n, J. Barycki n & M. Simpson n

author keywords: hexosamine biosynthesis pathway; hyaluronan; nucleotide sugars; UDP-glucuronate; UDP-N-acetylglucosamine
MeSH headings : Glycosaminoglycans; Hyaluronan Synthases / genetics; Hyaluronic Acid / metabolism; Nucleotides; Sugars; Uridine Diphosphate N-Acetylglucosamine / metabolism
Source: Web Of Science
Added: June 27, 2022

2021 review

Integration of Sugar Metabolism and Proteoglycan Synthesis by UDP-glucose Dehydrogenase

[Review of ]. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 69(1), 13–23.

By: B. Zimmer n, J. Barycki n & M. Simpson n

author keywords: developmental disorders; extracellular matrix; glucuronidation; glycosaminoglycan; hyaluronan; nucleotide sugars; post-translational modifications; proteoglycan; UDP-glucuronate
MeSH headings : Allosteric Regulation; Animals; Biosynthetic Pathways; Humans; Models, Molecular; Neoplasms / metabolism; Protein Processing, Post-Translational; Proteoglycans / metabolism; Sugars / metabolism; Uridine Diphosphate Glucose Dehydrogenase / chemistry; Uridine Diphosphate Glucose Dehydrogenase / metabolism
Source: Web Of Science
Added: August 24, 2020

2020 journal article

Loss-of-function mutations in UDP-Glucose 6-Dehydrogenase cause recessive developmental epileptic encephalopathy

NATURE COMMUNICATIONS, 11(1).

By: H. Hengel *, C. Bosso-Lefevre *, G. Grady n, E. Szenker-Ravi *, H. Li *, S. Pierce*, E. Lebigot *, T. Tan * ...

MeSH headings : Adolescent; Alleles; Animals; Child; Child, Preschool; Epilepsy / genetics; Female; Genes, Recessive; Humans; Infant; Kinetics; Loss of Function Mutation / genetics; Male; Organoids / pathology; Oxidoreductases / chemistry; Oxidoreductases / genetics; Pedigree; Protein Domains; Syndrome; Uridine Diphosphate Glucose Dehydrogenase / genetics; Zebrafish
Source: Web Of Science
Added: July 20, 2020

2017 article

Covering their bases: The phosphobase methylation pathway in plants

Barycki, J. J. (2017, December 29). JOURNAL OF BIOLOGICAL CHEMISTRY, Vol. 292, pp. 21703–21704.

By: J. Barycki n

author keywords: Arabidopsis thaliana; methyltransferase; phosphocholine; X-ray crystallography; enzyme kinetics; phosphatidylcholine; plant biochemistry
MeSH headings : Amino Acid Sequence; Crystallography, X-Ray; Methylation; Methyltransferases / metabolism; Methyltransferases / physiology; Phosphatidylcholines / biosynthesis; Phosphorylcholine / metabolism; Plants / metabolism
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Inhibiting Hexamer Disassembly of Human UDP-Glucose Dehydrogenase by Photoactivated Amino Acid Cross-Linking

Biochemistry, 55(22), 3157–3164.

By: G. Grady*, A. Thelen*, J. Albers*, T. Ju *, J. Guo *, J. Barycki*, M. Simpson*

MeSH headings : Amino Acids / chemistry; Amino Acids / radiation effects; Catalysis; Cross-Linking Reagents; Humans; Kinetics; Light; Models, Molecular; Oxidation-Reduction; Photochemical Processes; Protein Conformation; Protein Multimerization / radiation effects; Uridine Diphosphate Glucose / metabolism; Uridine Diphosphate Glucose Dehydrogenase / chemistry; Uridine Diphosphate Glucose Dehydrogenase / metabolism
Source: Crossref
Added: February 24, 2020

2016 journal article

Loss of exogenous androgen dependence by prostate tumor cells is associated with elevated glucuronidation potential

Hormones and Cancer, 7(4), 260–271.

By: B. Zimmer*, M. Howell *, Q. Wei *, L. Ma *, T. Romsdahl*, E. Loughman*, J. Markham *, J. Seravalli*, J. Barycki*, M. Simpson*

author keywords: Prostate cancer; Castration resistance; Dihydrotestosterone; Detoxification; LNCaP
MeSH headings : Androgens / pharmacology; Cell Line, Tumor; Gene Expression Regulation, Neoplastic / drug effects; Glucuronides / metabolism; Glucuronosyltransferase / metabolism; Humans; Kallikreins / genetics; Kallikreins / metabolism; Male; Minor Histocompatibility Antigens / metabolism; Models, Biological; Promoter Regions, Genetic; Prostate-Specific Antigen / genetics; Prostate-Specific Antigen / metabolism; Prostatic Neoplasms / genetics; Prostatic Neoplasms / metabolism; Prostatic Neoplasms, Castration-Resistant / genetics; Prostatic Neoplasms, Castration-Resistant / metabolism; Receptors, Androgen / metabolism; Uridine Diphosphate Glucose Dehydrogenase / metabolism
Source: Crossref
Added: February 24, 2020

2016 journal article

Potassium and the K+/H+ Exchanger Kha1p Promote Binding of Copper to ApoFet3p Multi-copper Ferroxidase

Journal of Biological Chemistry, 291(18), 9796–9806.

By: X. Wu *, H. Kim *, J. Seravalli*, J. Barycki*, P. Hart *, D. Gohara *, E. Di Cera *, W. Jung*, D. Kosman *, J. Lee*

MeSH headings : Ceruloplasmin / genetics; Ceruloplasmin / metabolism; Copper / metabolism; Gene Expression Regulation, Fungal / physiology; Iron; Potassium / metabolism; Potassium-Hydrogen Antiporters / biosynthesis; Potassium-Hydrogen Antiporters / genetics; Protein Binding; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism; Saccharomyces cerevisiae Proteins / biosynthesis; Saccharomyces cerevisiae Proteins / genetics; Saccharomyces cerevisiae Proteins / metabolism; Up-Regulation / physiology
Source: Crossref
Added: August 28, 2020

2015 journal article

Cytosolic Fe-S Cluster Protein Maturation and Iron Regulation Are Independent of the Mitochondrial Erv1/Mia40 Import System

Journal of Biological Chemistry, 290(46), 27829–27840.

By: H. Ozer*, A. Dlouhy*, J. Thornton*, J. Hu *, Y. Liu *, J. Barycki*, J. Balk *, C. Outten *

MeSH headings : Amino Acid Sequence; Cytosol / metabolism; Glutamate-Cysteine Ligase / metabolism; Glutathione / deficiency; Glutathione / metabolism; Iron / metabolism; Iron-Sulfur Proteins / metabolism; Mitochondria / metabolism; Mitochondrial Membrane Transport Proteins / genetics; Mitochondrial Membrane Transport Proteins / metabolism; Mitochondrial Precursor Protein Import Complex Proteins; Mitochondrial Proteins / genetics; Mitochondrial Proteins / metabolism; Molecular Sequence Data; Mutation; Oxidation-Reduction; Oxidoreductases / metabolism; Oxidoreductases Acting on Sulfur Group Donors / genetics; Oxidoreductases Acting on Sulfur Group Donors / metabolism; Protein Transport; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism; Saccharomyces cerevisiae / ultrastructure; Saccharomyces cerevisiae Proteins / genetics; Saccharomyces cerevisiae Proteins / metabolism
Source: Crossref
Added: February 24, 2020

2015 journal article

Hyaluronidase Hyal1 Increases Tumor Cell Proliferation and Motility through Accelerated Vesicle Trafficking

Journal of Biological Chemistry, 290(21), 13144–13156.

By: C. McAtee*, A. Berkebile*, C. Elowsky*, T. Fangman*, J. Barycki*, J. Wahl*, O. Khalimonchuk *, N. Naslavsky*, S. Caplan *, M. Simpson*

MeSH headings : Adenocarcinoma / metabolism; Adenocarcinoma / pathology; Antigens, Neoplasm / metabolism; Apoptosis; Blotting, Western; Cell Movement; Cell Proliferation; Endocytosis / physiology; Endosomes / metabolism; Histone Acetyltransferases / metabolism; Humans; Hyaluronic Acid / metabolism; Hyaluronoglucosaminidase / metabolism; Male; Prostatic Neoplasms / metabolism; Prostatic Neoplasms / pathology; Protein Transport; Subcellular Fractions; Transferrin / metabolism; Transport Vesicles / metabolism; Tumor Cells, Cultured
Source: Crossref
Added: February 24, 2020

2013 journal article

UDP-glucose Dehydrogenase Activity and Optimal Downstream Cellular Function Require Dynamic Reorganization at the Dimer-Dimer Subunit Interfaces

Journal of Biological Chemistry, 288(49), 35049–35057.

By: A. Hyde, A. Thelen, J. Barycki* & M. Simpson*

author keywords: Dehydrogenase; Enzyme Catalysis; Glycobiology; Hyaluronate; Prostate Cancer; Protein Conformation; Protein Dynamics; Cardiac Defects; Human UGDH; Hyaluronan
MeSH headings : Amino Acid Substitution; Enzyme Stability; HEK293 Cells; Humans; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Protein Interaction Domains and Motifs; Protein Multimerization; Protein Structure, Quaternary; Protein Subunits; Proteolysis; Thermodynamics; Uridine Diphosphate Glucose Dehydrogenase / chemistry; Uridine Diphosphate Glucose Dehydrogenase / genetics; Uridine Diphosphate Glucose Dehydrogenase / metabolism
Source: Crossref
Added: August 28, 2020

2012 journal article

UDP-glucose Dehydrogenase Polymorphisms from Patients with Congenital Heart Valve Defects Disrupt Enzyme Stability and Quaternary Assembly

Journal of Biological Chemistry, 287(39), 32708–32716.

By: A. Hyde*, E. Farmer*, K. Easley*, K. van Lammeren*, V. Christoffels *, J. Barycki*, J. Bakkers *, M. Simpson*

MeSH headings : Amino Acid Substitution; Animals; Animals, Genetically Modified / embryology; Animals, Genetically Modified / genetics; Enzyme Stability / genetics; Escherichia coli; Heart Defects, Congenital / embryology; Heart Defects, Congenital / enzymology; Heart Defects, Congenital / genetics; Heart Valve Diseases / embryology; Heart Valve Diseases / enzymology; Heart Valve Diseases / genetics; Heart Valves / embryology; Heart Valves / enzymology; Muscle Proteins / genetics; Muscle Proteins / metabolism; Mutation, Missense; Polymorphism, Genetic; Protein Structure, Quaternary; Recombinant Proteins / genetics; Recombinant Proteins / metabolism; Uridine Diphosphate Glucose Dehydrogenase; Zebrafish / embryology; Zebrafish / genetics; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism
Source: Crossref
Added: August 28, 2020

2011 journal article

Enzymatic Defects Underlying Hereditary Glutamate Cysteine Ligase Deficiency Are Mitigated by Association of the Catalytic and Regulatory Subunits

Biochemistry, 50(29), 6508–6517.

By: M. Willis*, Y. Liu *, E. Biterova*, M. Simpson*, H. Kim *, J. Lee *, J. Barycki*

MeSH headings : Animals; Catalytic Domain; Enzyme Stability; Glutamate-Cysteine Ligase / chemistry; Glutamate-Cysteine Ligase / deficiency; Glutamate-Cysteine Ligase / metabolism; Glutathione / biosynthesis; Homozygote; Humans; Kinetics; Mice; Models, Biological; Mutant Proteins / metabolism; Mutation / genetics; Protein Binding; Protein Structure, Secondary; Recombinant Proteins / metabolism; Saccharomyces cerevisiae / metabolism; Structural Homology, Protein; Temperature
Source: Crossref
Added: August 28, 2020

2010 journal article

Structural Basis for Feedback and Pharmacological Inhibition of Saccharomyces cerevisiae Glutamate Cysteine Ligase

Journal of Biological Chemistry, 285(19), 14459–14466.

By: E. Biterova* & J. Barycki*

MeSH headings : Adenosine Triphosphate / metabolism; Binding Sites; Buthionine Sulfoximine / metabolism; Crystallization; Crystallography, X-Ray; Enzyme Inhibitors / metabolism; Glutamate-Cysteine Ligase / chemistry; Glutamate-Cysteine Ligase / genetics; Glutamate-Cysteine Ligase / metabolism; Glutathione / metabolism; Kinetics; Models, Chemical; Models, Molecular; Mutagenesis, Site-Directed; Mutation / genetics; Protein Conformation; Saccharomyces cerevisiae / enzymology; Saccharomyces cerevisiae / genetics
Source: Crossref
Added: October 29, 2020

2009 journal article

Crystal Structure of Acivicin-Inhibited γ-Glutamyltranspeptidase Reveals Critical Roles for Its C-Terminus in Autoprocessing and Catalysis†‡

Biochemistry, 48(11), 2459–2467.

By: K. Williams*, S. Cullati *, A. Sand*, E. Biterova* & J. Barycki*

MeSH headings : Amino Acid Motifs; Amino Acid Sequence; Bacterial Proteins / antagonists & inhibitors; Bacterial Proteins / chemistry; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Catalysis; Crystallography, X-Ray; Enzyme Inhibitors / chemistry; Helicobacter pylori / chemistry; Helicobacter pylori / enzymology; Helicobacter pylori / genetics; Isoxazoles / chemistry; Kinetics; Models, Molecular; Molecular Sequence Data; Protein Binding; Protein Processing, Post-Translational; Sequence Alignment; Substrate Specificity; gamma-Glutamyltransferase / antagonists & inhibitors; gamma-Glutamyltransferase / chemistry; gamma-Glutamyltransferase / genetics; gamma-Glutamyltransferase / metabolism
Source: Crossref
Added: August 28, 2020

2009 journal article

Hyaluronidase Activity of Human Hyal1 Requires Active Site Acidic and Tyrosine Residues

Journal of Biological Chemistry, 284(14), 9433–9442.

By: L. Zhang *, A. Bharadwaj *, A. Casper*, J. Barkley*, J. Barycki* & M. Simpson*

MeSH headings : Acids / chemistry; Biocatalysis; Catalytic Domain; Cell Line; Crystallography, X-Ray; Disulfides / chemistry; Glycosylation; Humans; Hyaluronoglucosaminidase / chemistry; Hyaluronoglucosaminidase / genetics; Hyaluronoglucosaminidase / metabolism; Hydrogen-Ion Concentration; Kinetics; Models, Molecular; Mutation / genetics; Oligosaccharides / chemistry; Oligosaccharides / metabolism; Protein Structure, Tertiary; Tyrosine / genetics; Tyrosine / metabolism
Source: Crossref
Added: August 28, 2020

2009 journal article

Mechanistic Details of Glutathione Biosynthesis Revealed by Crystal Structures of Saccharomyces cerevisiae Glutamate Cysteine Ligase

Journal of Biological Chemistry, 284(47), 32700–32708.

By: E. Biterova* & J. Barycki*

MeSH headings : Binding Sites; Catalytic Domain; Crystallography, X-Ray / methods; Escherichia coli / metabolism; Glutamate-Cysteine Ligase / chemistry; Glutathione / chemistry; Humans; Magnesium / chemistry; Magnesium Chloride / chemistry; Models, Molecular; Mutation; Protein Conformation; Protein Processing, Post-Translational; Saccharomyces cerevisiae / metabolism; Software; Sulfhydryl Compounds / chemistry
Source: Crossref
Added: August 28, 2020

2007 journal article

Characterization of Helicobacter pyloriγ-Glutamyltranspeptidase Reveals the Molecular Basis for Substrate Specificity and a Critical Role for the Tyrosine 433-Containing Loop in Catalysis†,‡

Biochemistry, 46(46), 13407–13414.

By: A. Morrow *, K. Williams*, A. Sand*, G. Boanca* & J. Barycki*

MeSH headings : Binding Sites; Catalysis; Crystallography, X-Ray; Glutamic Acid / chemistry; Glutamic Acid / metabolism; Helicobacter pylori / enzymology; Hydrolysis; Kinetics; Ligands; Models, Molecular; Protein Structure, Tertiary; Substrate Specificity; Tyrosine / chemistry; Tyrosine / genetics; gamma-Glutamyltransferase / chemistry; gamma-Glutamyltransferase / genetics; gamma-Glutamyltransferase / metabolism
Source: Crossref
Added: October 29, 2020

2007 journal article

Characterization of Human UDP-Glucose Dehydrogenase Reveals Critical Catalytic Roles for Lysine 220 and Aspartate 280†

Biochemistry, 46(2), 369–378.

By: K. Easley*, B. Sommer*, G. Boanca*, J. Barycki* & M. Simpson*

MeSH headings : Amino Acid Substitution; Aspartic Acid / chemistry; Catalytic Domain / genetics; Dimerization; Humans; In Vitro Techniques; Kinetics; Lysine / chemistry; Models, Molecular; Mutagenesis, Site-Directed; Protein Structure, Quaternary; Recombinant Proteins / chemistry; Recombinant Proteins / genetics; Recombinant Proteins / metabolism; Uridine Diphosphate Glucose Dehydrogenase / chemistry; Uridine Diphosphate Glucose Dehydrogenase / genetics; Uridine Diphosphate Glucose Dehydrogenase / metabolism
Source: Crossref
Added: August 28, 2020

2006 journal article

Uncoupling the Enzymatic and Autoprocessing Activities of Helicobacter pylori γ-Glutamyltranspeptidase

Journal of Biological Chemistry, 281(28), 19029–19037.

By: G. Boanca*, A. Sand* & J. Barycki*

MeSH headings : Bacterial Proteins / chemistry; Biochemistry / methods; Helicobacter pylori / enzymology; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Peptides / chemistry; Protein Structure, Tertiary; Recombinant Proteins / chemistry; Threonine / chemistry; Time Factors; gamma-Glutamyltransferase / chemistry
Source: Crossref
Added: October 29, 2020

2005 journal article

Crystal structures of oxidized and reduced mitochondrial thioredoxin reductase provide molecular details of the reaction mechanism

Proceedings of the National Academy of Sciences, 102(42), 15018–15023.

By: E. Biterova*, A. Turanov*, V. Gladyshev * & J. Barycki*

author keywords: disulfide; flavoprotein; selenocysteine; selenoprotein
MeSH headings : Animals; Binding Sites; Crystallography, X-Ray; Homeostasis; Isoenzymes / chemistry; Isoenzymes / metabolism; Mice; Mitochondria / enzymology; Models, Molecular; NADP / metabolism; Oxidation-Reduction; Protein Structure, Quaternary; Protein Subunits / chemistry; Protein Subunits / metabolism; Thioredoxin Reductase 2; Thioredoxin-Disulfide Reductase / chemistry; Thioredoxin-Disulfide Reductase / metabolism
Source: Crossref
Added: August 28, 2020

2004 journal article

Characterization of Human UDP-glucose Dehydrogenase

Journal of Biological Chemistry, 279(22), 23590–23596.

By: B. Sommer*, J. Barycki* & M. Simpson*

MeSH headings : Binding Sites; Catalytic Domain / genetics; Cysteine; Humans; Lysine; Oxidation-Reduction; Protein Conformation; Streptococcus pyogenes; Structure-Activity Relationship; Uridine Diphosphate Glucose Dehydrogenase / chemistry; Uridine Diphosphate Glucose Dehydrogenase / genetics; Uridine Diphosphate Glucose Dehydrogenase / metabolism
Source: Crossref
Added: August 28, 2020