Joe Barycki

Recent insights into the implications of UGDH mutations for human developmental disease

Harwood, H., Zimmer, B. M., Utz, A. R., Barycki, J. J., & Simpson, M. A. (2025, August 28). Biochemical Society Transactions, Vol. 8.

Mechanisms of coordinating hyaluronan and glycosaminoglycan production by nucleotide sugars

Zimmer, B. M., Barycki, J. J., & Simpson, M. A. (2022, April 20). American Journal of Physiology-Cell Physiology, Vol. 322, pp. C1201–C1213.

Altered glucuronidation deregulates androgen dependent response profiles and signifies castration resistance in prostate cancer

Zimmer, B. M., Howell, M. E., Ma, L., Enders, J. R., Lehman, D., Corey, E., … Simpson, M. A. (2021, August 25). Oncotarget, Vol. 12, pp. 1886–1902.

Integration of Sugar Metabolism and Proteoglycan Synthesis by UDP-glucose Dehydrogenase

Zimmer, B. M., Barycki, J. J., & Simpson, M. A. (2020, August 4). Journal of Histochemistry & Cytochemistry, Vol. 69, pp. 13–23.

Loss-of-function mutations in UDP-Glucose 6-Dehydrogenase cause recessive developmental epileptic encephalopathy

Hengel, H., Bosso-Lefèvre, C., Grady, G., Szenker-Ravi, E., Li, H., Pierce, S., … Reversade, B. (2020, January 30). Nature Communications, Vol. 11.

Covering their bases: The phosphobase methylation pathway in plants

Barycki, J. J. (2017, December 1). Journal of Biological Chemistry, Vol. 292, pp. 21703–21704.

Inhibiting Hexamer Disassembly of Human UDP-Glucose Dehydrogenase by Photoactivated Amino Acid Cross-Linking

Biochemistry, 55(22), 3157–3164.

Loss of exogenous androgen dependence by prostate tumor cells is associated with elevated glucuronidation potential

Hormones and Cancer, 7(4), 260–271.

Potassium and the K+/H+ Exchanger Kha1p Promote Binding of Copper to ApoFet3p Multi-copper Ferroxidase

Journal of Biological Chemistry, 291(18), 9796–9806.

Cytosolic Fe-S Cluster Protein Maturation and Iron Regulation Are Independent of the Mitochondrial Erv1/Mia40 Import System

Journal of Biological Chemistry, 290(46), 27829–27840.

Hyaluronidase Hyal1 Increases Tumor Cell Proliferation and Motility through Accelerated Vesicle Trafficking

Journal of Biological Chemistry, 290(21), 13144–13156.

Emerging Regulatory Paradigms in Glutathione Metabolism

Liu, Y., Hyde, A. S., Simpson, M. A., & Barycki, J. J. (2014, January 1). Advances in Cancer Research, Vol. 122, pp. 69–101.

Emerging Roles for Hyaluronidase in Cancer Metastasis and Therapy

McAtee, C. O., Barycki, J. J., & Simpson, M. A. (2014, January 1). Advances in Cancer Research, Vol. 123, pp. 1–34.

UDP-glucose Dehydrogenase Activity and Optimal Downstream Cellular Function Require Dynamic Reorganization at the Dimer-Dimer Subunit Interfaces

Journal of Biological Chemistry, 288(49), 35049–35057.

Glutathione

Barycki, J. J. (2012, December 5). Encyclopedia of Biophysics, pp. 900–902.

UDP-glucose Dehydrogenase Polymorphisms from Patients with Congenital Heart Valve Defects Disrupt Enzyme Stability and Quaternary Assembly

Journal of Biological Chemistry, 287(39), 32708–32716.

Enzymatic Defects Underlying Hereditary Glutamate Cysteine Ligase Deficiency Are Mitigated by Association of the Catalytic and Regulatory Subunits

Biochemistry, 50(29), 6508–6517.

Structural Basis for Feedback and Pharmacological Inhibition of Saccharomyces cerevisiae Glutamate Cysteine Ligase

Journal of Biological Chemistry, 285(19), 14459–14466.

Crystal Structure of Acivicin-Inhibited γ-Glutamyltranspeptidase Reveals Critical Roles for Its C-Terminus in Autoprocessing and Catalysis†‡

Biochemistry, 48(11), 2459–2467.

Hyaluronidase Activity of Human Hyal1 Requires Active Site Acidic and Tyrosine Residues

Journal of Biological Chemistry, 284(14), 9433–9442.

Mechanistic Details of Glutathione Biosynthesis Revealed by Crystal Structures of Saccharomyces cerevisiae Glutamate Cysteine Ligase

Journal of Biological Chemistry, 284(47), 32700–32708.

Antioxidant Molecules and Redox Cofactors

Barycki, J. J., Asard, H., Stone, J. M., Wilson, M. A., Banerjee, R., & Becker, D. F. (2007, March 14). Redox Biochemistry, pp. 11–47.

Characterization of Helicobacter pyloriγ-Glutamyltranspeptidase Reveals the Molecular Basis for Substrate Specificity and a Critical Role for the Tyrosine 433-Containing Loop in Catalysis†,‡

Biochemistry, 46(46), 13407–13414.

Autoprocessing of Helicobacter pylori γ-Glutamyltranspeptidase Leads to the Formation of a Threonine-Threonine Catalytic Dyad

Boanca, G., Sand, A., Okada, T., Suzuki, H., Kumagai, H., Fukuyama, K., & Barycki, J. J. (2006, November 16). Journal of Biological Chemistry, Vol. 282, pp. 534–541.

Characterization of Human UDP-Glucose Dehydrogenase Reveals Critical Catalytic Roles for Lysine 220 and Aspartate 280†

Characterization of Human UDP-Glucose Dehydrogenase Reveals Critical Catalytic Roles for Lysine 220 and Aspartate 280. Biochemistry, 46(2), 369–378.

Uncoupling the Enzymatic and Autoprocessing Activities of Helicobacter pylori γ-Glutamyltranspeptidase

Journal of Biological Chemistry, 281(28), 19029–19037.

A Three-component Dicamba O-Demethylase from Pseudomonas maltophilia, Strain DI-6

Herman, P. L., Behrens, M., Chakraborty, S., Chrastil, B. M., Barycki, J., & Weeks, D. P. (2005, April 27). Journal of Biological Chemistry, Vol. 280, pp. 24759–24767.

Crystal structures of oxidized and reduced mitochondrial thioredoxin reductase provide molecular details of the reaction mechanism

Proceedings of the National Academy of Sciences, 102(42), 15018–15023.

5‐Hydroxydecanoate is metabolised in mitochondria and creates a rate‐limiting bottleneck for β‐oxidation of fatty acids

Hanley, P. J., Dröse, S., Brandt, U., Lareau, R. A., Banerjee, A. L., Srivastava, D. K., … Daut, J. (2004, October 29). The Journal of Physiology, Vol. 562, pp. 307–318.

Characterization of Human UDP-glucose Dehydrogenase

: CYS-276 is required for the second of two successive oxidations. Journal of Biological Chemistry, 279(22), 23590–23596.

Glutamate 170 of Human l-3-Hydroxyacyl-CoA Dehydrogenase Is Required for Proper Orientation of the Catalytic Histidine and Structural Integrity of the Enzyme

Barycki, J. J., O'Brien, L. K., Strauss, A. W., & Banaszak, L. J. (2001, September 1). Journal of Biological Chemistry, Vol. 276, pp. 36718–36726.

Probing subunit interactions in glutathione S-transferases using affinity labeling

Chemico-Biological Interactions, 133(1-3), 159–162. http://www.scopus.com/inward/record.url?eid=2-s2.0-0000336613&partnerID=MN8TOARS

Sequestration of the active site by interdomain shifting: crystallographic and spectroscopic evidence for distinct conformations of L-3-Hydroxyacyl-CoA dehydrogenase

Barycki, J. J. (2000, June 5). Journal of Biological Chemistry, Vol. 275, pp. 27186–27196.

Affinity labeling of rat GST A1-1 by 3β-(iodoacetoxy)dehydroisoandrosterone

Clinical Chemistry and Enzymology Communications, 8(4-6), 255–259. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033503787&partnerID=MN8TOARS

Biochemical Characterization and Crystal Structure Determination of Human Heart Short Chain l-3-Hydroxyacyl-CoA Dehydrogenase Provide Insights into Catalytic Mechanism

Barycki, J. J., O'Brien, L. K., Bratt, J. M., Zhang, R., Sanishvili, R., Strauss, A. W., & Banaszak, L. J. (1999, April 14). Biochemistry, Vol. 38, pp. 5786–5798.

Pig heart short chain L‐3‐hydroxyacyl‐CoA dehydrogenase revisited: Sequence analysis and crystal structure determination

Barycki, J. J., O'Brien, L. K., Birktoft, J. J., Strauss, A. W., & Banaszak, L. J. (1999, January 1). Protein Science, Vol. 8, pp. 2010–2018.

Identification of the Nonsubstrate Steroid Binding Site of Rat Liver GlutathioneS-Transferase, Isozyme 1-1, by the Steroid Affinity Label, 3β-(Iodoacetoxy)dehydroisoandrosterone

Barycki, J. J., & Colman, R. F. (1997, September 1). Archives of Biochemistry and Biophysics, Vol. 345, pp. 16–31.

Tyrosine 8 contributes to catalysis but is not required for activity of rat liver glutathione S‐transferase, 1–1

Wang, J., Barycki, J. J., & Colman, R. F. (1996, June 1). Protein Science, Vol. 5, pp. 1032–1042.

Affinity labeling of glutathione S-transferase, isozyme 4-4, by 4-(fluorosulfonyl)benzoic acid reveals Tyr115 to be an important determinant of xenobiotic substrate specificity

Barycki, J. J., & Colman, R. F. (1993, December 1). Biochemistry, Vol. 32, pp. 13002–13011.