Joel Lapin

College of Sciences

Works (6)

Updated: July 7th, 2023 21:13

2022 article

Validation of protein backbone structures calculated from NMR angular restraints using Rosetta (vol 73, pg 229, 2019)

Lapin, J., & Nevzorov, A. A. (2022, August 27). JOURNAL OF BIOMOLECULAR NMR.

By: J. Lapin n & A. Nevzorov n

TL;DR: A framework for de-novo protein structure prediction using a combination of solid-state NMR angular restraints and bioinformatics is established and Rosetta was able to distinguish the most plausible structures. (via Semantic Scholar)
Source: Web Of Science
Added: September 12, 2022

2021 journal article

H-1/C-13/N-15 triple-resonance experiments for structure determinaton of membrane proteins by oriented-sample NMR

SOLID STATE NUCLEAR MAGNETIC RESONANCE, 111.

By: J. Lapin n, E. Awosanya n, R. Esteves n & A. Nevzorov n

author keywords: NMR pulse sequence design; Triple-resonance experiments; Dipolar couplings; Separated local-field spectroscopy; ROULETTE; Membrane proteins; Structure determination; Heteronuclear correlations
MeSH headings : Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy / methods; Membrane Proteins / chemistry; Nuclear Magnetic Resonance, Biomolecular / methods; Protons
TL;DR: The presented developments advance NMR of oriented samples for structure determination of membrane proteins and liquid crystals in solid-state NMR experiments. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: March 8, 2021

2020 journal article

Computer-generated pulse sequences for H-1-N-15 and H-1(alpha)-C-13(alpha) separated local-field experiments

JOURNAL OF MAGNETIC RESONANCE, 317.

By: J. Lapin n & A. Nevzorov n

author keywords: NMR pulse sequence design; Automation; Simulated annealing; GPU computing; Separated local field experiments; Dipolar couplings; PISEMA; SAMPI4; ROULETTE
TL;DR: The new algorithm, in addition to finding pulse durations and phases, now searches for the optimal on/off application scheme of radio frequency irradiation on each channel, effectively optimizing every aspect of a pulse sequence instead of just phases and durations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 24, 2020

2020 journal article

De novo NMR pulse sequence design using Monte-Carlo optimization techniques

JOURNAL OF MAGNETIC RESONANCE, 310.

By: J. Lapin n & A. Nevzorov n

MeSH headings : Algorithms; Bacteriophage Pf1 / chemistry; Capsid Proteins / chemistry; Computer Simulation; Crystallization; Hydrogen; Leucine / analogs & derivatives; Leucine / chemistry; Monte Carlo Method; Nitrogen Isotopes; Nuclear Magnetic Resonance, Biomolecular / methods
TL;DR: A computational strategy was developed to find the optimal phases and timings that substantially improve the 1H-15N dipolar linewidths over a broad range of dipolar couplings as compared to SAMPI4. (via Semantic Scholar)
Source: Web Of Science
Added: January 13, 2020

2020 journal article

NMR "Crystallography" for Uniformly (C-13, N-15)-Labeled Oriented Membrane Proteins

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 59(9), 3554–3557.

By: E. Awosanya n, J. Lapin n & A. Nevzorov n

author keywords: dipolar couplings; membrane proteins; nuclear magnetic resonance; oriented samples; structure determination
MeSH headings : Carbon Isotopes / chemistry; Inovirus / metabolism; Isotope Labeling; Lipid Bilayers / chemistry; Lipid Bilayers / metabolism; Membrane Proteins / chemistry; Nitrogen Isotopes / chemistry; Nuclear Magnetic Resonance, Biomolecular; Viral Proteins / chemistry
TL;DR: A new experimental triple-resonance NMR technique was applied to uniformly doubly labeled Pf1 coat protein in magnetically aligned DMPC/DHPC bicelles and yielded a consensus α-helical transmembrane structure for Pf1 protein. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: February 10, 2020

2019 journal article

Validation of protein backbone structures calculated from NMR angular restraints using Rosetta

JOURNAL OF BIOMOLECULAR NMR, 73(5), 229–244.

By: J. Lapin n & A. Nevzorov n

author keywords: Oriented-sample NMR; Angular restraints; Dipolar couplings; Chemical shift anisotropy; Membrane proteins; Structure determination; Rosetta
MeSH headings : Magnetic Resonance Spectroscopy / methods; Membrane Proteins / chemistry; Protein Conformation
TL;DR: A significantly improved version of the algorithm which includes the fitting of several peptide planes at once in order to prevent propagation of error along the backbone and establishes a framework for de-novo protein structure prediction using a combination of solid-state NMR angular restraints and bioinformatics. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: July 1, 2019

Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.

Certain data included herein are derived from the Web of Science© and InCites© (2024) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.