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Works (17)
Updated: April 10th, 2024 05:00
2024 journal article
Inhalation of ACE2-expressing lung exosomes provides prophylactic protection against SARS-CoV-2
NATURE COMMUNICATIONS, 15(1).
Sources: Web Of Science, NC State University Libraries
Added: April 8, 2024
2023 journal article
An inhaled bioadhesive hydrogel to shield non-human primates from SARS-CoV-2 infection
Nature Materials, 2.
TL;DR:
A physical barrier against SARS-CoV-2 infection based on an inhalable bioadhesive hydrogel, named spherical hydrogels inhalation for enhanced lung defence (SHIELD), which is conveniently delivered via a dry powder inhaler and made with food-grade materials and does not affect normal respiratory functions.
(via Semantic Scholar)
www.nature.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: March 6, 2023
2023 journal article
Comparison of extruded cell nanovesicles and exosomes in their molecular cargos and regenerative potentials
NANO RESEARCH, 16(5), 7248–7259.
author keywords: nanovesicles (NVs); exosomes; cardiac repair; mesenchymal stem cells (MSCs); extracellular vesicles (EVs); myocardial infarction (Ml)
TL;DR:
Proteomics and RNA sequencing data revealed that NVs resemble MSCs more closely than EVs, and microRNAs in NVs are related to cardiac repair, fibrosis repression, and angiogenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 28, 2023
2023 journal article
Intrapericardial long non-coding RNA–<i>Tcf21</i> antisense RNA inducing demethylation administration promotes cardiac repair
European Heart Journal, 44(19), 1748–1760.
author keywords: Myocardial infarction; Adverse remodelling; Mesenchymal stem cell; EVs; lncRNA; Tcf21
MeSH headings : Mice; Animals; Swine; RNA, Long Noncoding / genetics; RNA, Long Noncoding / metabolism; RNA, Antisense / genetics; RNA, Antisense / metabolism; Ventricular Remodeling; Myocardial Infarction / genetics; Myocardial Infarction / therapy; Myocardial Infarction / metabolism; Fibrosis; Demethylation
TL;DR:
Novel mechanisms underlying EV therapy for improving adverse remodelling are established and a lncRNA therapy for cardiac fibrosis is proposed, which could be a promising way to treat myocardial fibrosis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: April 4, 2023
2022 journal article
Inhalable dry powder mRNA vaccines based on extracellular vesicles
Matter, 5(9), 2960–2974.
TL;DR:
The results suggest that extracellular vesicles can serve as an inhaled mRNA drug-delivery system that is superior to synthetic liposomes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: October 17, 2022
2022 journal article
Intrapericardial Exosome Therapy Dampens Cardiac Injury via Activating Foxo3
CIRCULATION RESEARCH, 131(10), E135–E150.
author keywords: exosomes; immunomodulation; mesesnchymal stem cell; myocardial infarction; regulatory T cell
MeSH headings : Humans; Exosomes / metabolism; Forkhead Box Protein O3 / genetics; Forkhead Box Protein O3 / metabolism; Mesenchymal Stem Cells / metabolism; Myocardial Infarction / pathology; Proto-Oncogene Proteins c-akt / metabolism; Signal Transduction; Heart Injuries / metabolism
TL;DR:
A novel mechanism underlying the immunomodulation effects of MSC exosomes is revealed and provides a promising candidate (PP2A/p-Akt/Foxo3 signaling pathway) with a favorable delivery route (intrapericardial injection) for cardiac repair.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 14, 2022
2022 journal article
Intrapericardial hydrogel injection generates high cell retention and augments therapeutic effects of mesenchymal stem cells in myocardial infarction
CHEMICAL ENGINEERING JOURNAL, 427.
author keywords: Mesenchymal stem cells; Hydrogel; Myocardial infarction; Intrapericardial; Intramyocardial
TL;DR:
Intrapericardial cavity injection gave a promising solution for the low retention issue of MSCs in the infarcted heart and the feasibility and safety of IPC injection were demonstrated in a porcine model with minimally invasive procedure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 3, 2022
2022 journal article
Nanoparticles functionalized with stem cell secretome and CXCR4-overexpressing endothelial membrane for targeted osteoporosis therapy
JOURNAL OF NANOBIOTECHNOLOGY, 20(1).
Contributors: C. Zhang *, W. Zhang *, D. Zhu n , Z. Li n, Z. Wang n, n, X. Mei n, W. Xu *, K. Cheng n, B. Zhong*
author keywords: Osteoporosis; CXCR4; Secretome; Mesenchymal stem cells; Bone targeting; Nanoparticles
MeSH headings : Animals; Cell Membrane / chemistry; Cell Membrane / metabolism; Disease Models, Animal; Endothelial Cells / chemistry; Endothelial Cells / metabolism; Mesenchymal Stem Cells / chemistry; Mesenchymal Stem Cells / metabolism; Nanoparticle Drug Delivery System; Nanoparticles; Osteoporosis / metabolism; Rats; Receptors, CXCR4 / metabolism; Secretome / metabolism
TL;DR:
In a rat model of osteoporosis, MSC-Sec/CXCR4 NP were found to accumulate in bone, and such treatment inhibited osteoclast differentiation while promoting osteogenic proliferation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 24, 2022
2021 journal article
A Minimally Invasive Exosome Spray Repairs Heart after Myocardial Infarction
ACS NANO, 15(7), 11099–11111.
Contributors: J. Yao *, K. Huang n , D. Zhu n , T. Chen *, Y. Jiang *, J. Zhang *, L. Mi*, H. Xuan
author keywords: MSC; exosome; spray; myocardial infarction; heart repair
MeSH headings : Mice; Swine; Animals; Exosomes; Myocardial Infarction / therapy; Mesenchymal Stem Cells; Heart; Disease Models, Animal
TL;DR:
In a mouse model of acute myocardial infarction, EXOS improved cardiac function and reduced fibrosis, and promoted endogenous angiomyogenesis in the post-injury heart, indicating that EXOS is a promising strategy to deliver therapeutic exosomes for heart repair.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 23, 2021
2021 journal article
A fluid-powered refillable origami heart pouch for minimally invasive delivery of cell therapies in rats and pigs
MED, 2(11), 1253-+.
MeSH headings : Animals; Cell- and Tissue-Based Therapy; Heart; Mesenchymal Stem Cell Transplantation / methods; Mesenchymal Stem Cells; Myocardial Infarction / surgery; Rats; Swine
TL;DR:
A fluid-driven heart pouch with a memory-shaped microfabricated lattice structure inspired by origami allowed minimally invasive delivery of the pouch to the heart with two small incisions and can be refilled multiple times with the therapeutic of choice.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 3, 2021
2021 journal article
A stem cell-derived ovarian regenerative patch restores ovarian function and rescues fertility in rats with primary ovarian insufficiency
THERANOSTICS, 11(18), 8894–8908.
author keywords: primary ovarian insufficiency; ovarian regenerative patch; regenerative medicine; mesenchymal stem cells; acellular therapy; fertility
MeSH headings : Animals; Apoptosis; Cell-Derived Microparticles / metabolism; Disease Models, Animal; Female; Hydrogels / pharmacology; Infertility, Female / therapy; Mesenchymal Stem Cell Transplantation / methods; Mesenchymal Stem Cells / metabolism; Ovary / pathology; Primary Ovarian Insufficiency / therapy; Rats; Rats, Sprague-Dawley; Regenerative Medicine / methods; Secretome; Stem Cells / metabolism; Tissue Scaffolds
TL;DR:
In a rat model of POI, implantation of ORP rescued fertility by restoring sexual hormone secretion, estrus cycle duration, and follicle development and represents a cell-free, off-the-shelf, and clinically feasible treatment for POI.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 12, 2021
2021 journal article
A trifunctional contraceptive gel enhances the safety and quality of sexual intercourse
BIOACTIVE MATERIALS, 6(6), 1777–1788.
author keywords: Contraceptive; Hydrogel; Anti-viral; Libido; Erectile function
TL;DR:
A novel TGN contraceptive gel consisting of three agents: tenofovir, gossypol acetate, and nitroglycerin (TGN) yielded a higher contraceptive success rate than that of the commercial contraceptive gel (Contragel®), and has the added benefits to prevent sexually transmitted diseases and improve male libido and erection function during sexual intercourse.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 6, 2021
2021 review
Advances in biomaterials and regenerative medicine for primary ovarian insufficiency therapy
[Review of ]. BIOACTIVE MATERIALS, 6(7), 1957–1972.
author keywords: Stem cells; Primary ovarian insufficiency; Cell therapy; Biomaterials
TL;DR:
A thorough understanding of the work already done can aid in the development of guidelines for future translational applications and clinical trials that aim to cure POI by using regenerative medicine and biomedical engineering strategies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 6, 2021
2021 review
All Roads Lead to Rome (the Heart): Cell Retention and Outcomes From Various Delivery Routes of Cell Therapy Products to the Heart
[Review of ]. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 10(8).
author keywords: cardiac repair; cell delivery; intracoronary; intramyocardial; intrapericardial; intravenous; retention rate
MeSH headings : Animals; Cell- and Tissue-Based Therapy / methods; Heart Diseases / therapy; Humans; Injections
TL;DR:
An in‐depth study of primary theories of cell loss, including low efficiency in cell injection, “washout” effects, and cell death, is undertaken and the literature from the past decade that focuses on cell transplantation to the heart using various cell delivery routes is organized.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 10, 2021
2021 journal article
Extruded Mesenchymal Stem Cell Nanovesicles Are Equally Potent to Natural Extracellular Vesicles in Cardiac Repair
ACS APPLIED MATERIALS & INTERFACES, 13(47), 55767–55779.
author keywords: extrusion; nanovesicles; extracellular vesicles; mesenchymal stem cell; ischemia reperfusion injury
MeSH headings : Animals; Disease Models, Animal; Endothelial Cells / drug effects; Endothelial Cells / pathology; Extracellular Vesicles / chemistry; Fibroblasts / drug effects; Fibroblasts / pathology; Mesenchymal Stem Cells / chemistry; Mesenchymal Stem Cells / cytology; Mice; Myocardial Infarction / drug therapy; Myocardial Infarction / pathology; Myocytes, Cardiac / drug effects; Myocytes, Cardiac / pathology; Nanoparticles / chemistry; Particle Size; Surface Properties
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 21, 2022
2021 journal article
Platelet membrane and stem cell exosome hybrids enhance cellular uptake and targeting to heart injury
NANO TODAY, 39.
author keywords: Exosomes; Targeting; Myocardial infarction; Platelet membrane; Stem cells
TL;DR:
It is found that encapsulation by the platelet membranes induces macropinocytosis, enhancing the cellular uptake of exosomes by endothelial cells and cardiomyocytes strikingly and boosting the cardiac targeting ability of hybrid exosome in a mice model with myocardial infarction injury.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 7, 2021
2020 review
Engineering better stem cell therapies for treating heart diseases
[Review of ]. ANNALS OF TRANSLATIONAL MEDICINE, 8(8).
author keywords: Stem cell therapy; ischemic heart diseases; bioengineering strategies; clinical translation
TL;DR:
This review will provide a brief summary of stem cell therapies for ischemic heart disease, the investigation of mechanisms behind stem-cell based cardiac regeneration and also, what bioengineers can do and have been doing on the translational stage of stem Cell therapies for heart repair.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 26, 2020
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