Junlang Li

Works (20)

Updated: October 1st, 2024 05:02

2024 journal article

An infusible biologically active adhesive for chemotherapy-related heart failure in elderly rats

BIOACTIVE MATERIALS, 40, 571–581.

By: J. Yao *, J. Li n, D. Zhu n , Y. Li n , P. Tasoudis *, S. Liu n, X. Mei *, K. Popowski n  ...

author keywords: Secretomes; Cardiac stromal cells; Extracellular matrix; Chemotherapy; Heart failure; Intrapericardial injection
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 1, 2024

2024 journal article

Inhalable Stem Cell Exosomes Promote Heart Repair After Myocardial Infarction

CIRCULATION, 150(9), 710–723.

By: J. Li n, S. Sun *, D. Zhu* , X. Mei*, Y. Lyu n, K. Huang n , Y. Li n , S. Liu* ...

author keywords: CD36; extracellular vesicles; exosomes; inhalation; myocardial infarction
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 1, 2024

2024 journal article

Inhalation of ACE2-expressing lung exosomes provides prophylactic protection against SARS-CoV-2

NATURE COMMUNICATIONS, 15(1).

By: Z. Wang*, S. Hu* , K. Popowski n , S. Liu*, D. Zhu* , X. Mei n, J. Li*, Y. Hu * ...

UN Sustainable Development Goals Color Wheel
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Sources: Web Of Science, NC State University Libraries
Added: April 8, 2024

2024 journal article

Optimizing cell therapy by sorting cells with high extracellular vesicle secretion

NATURE COMMUNICATIONS, 15(1).

By: D. Koo *, X. Cheng n, S. Udani *, S. Baghdasarian*, D. Zhu* , J. Li*, B. Hall, N. Tsubamoto* ...

UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: July 8, 2024

2023 journal article

An inhaled bioadhesive hydrogel to shield non-human primates from SARS-CoV-2 infection

Nature Materials, 2.

By: X. Mei n, J. Li n, Z. Wang n, D. Zhu n , K. Huang n , S. Hu n , K. Popowski n , K. Cheng n

TL;DR: A physical barrier against SARS-CoV-2 infection based on an inhalable bioadhesive hydrogel, named spherical hydrogels inhalation for enhanced lung defence (SHIELD), which is conveniently delivered via a dry powder inhaler and made with food-grade materials and does not affect normal respiratory functions. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: March 6, 2023

2023 journal article

Comparison of extruded cell nanovesicles and exosomes in their molecular cargos and regenerative potentials

NANO RESEARCH, 16(5), 7248–7259.

By: X. Wang *, S. Hu n , D. Zhu n , J. Li n, K. Cheng n & G. Liu

author keywords: nanovesicles (NVs); exosomes; cardiac repair; mesenchymal stem cells (MSCs); extracellular vesicles (EVs); myocardial infarction (Ml)
TL;DR: Proteomics and RNA sequencing data revealed that NVs resemble MSCs more closely than EVs, and microRNAs in NVs are related to cardiac repair, fibrosis repression, and angiogenesis. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 28, 2023

2023 journal article

Intrapericardial long non-coding RNA–<i>Tcf21</i> antisense RNA inducing demethylation administration promotes cardiac repair

European Heart Journal, 44(19), 1748–1760.

By: D. Zhu n , S. Liu n, K. Huang n , J. Li n, X. Mei n, Z. Li n, K. Cheng n

author keywords: Myocardial infarction; Adverse remodelling; Mesenchymal stem cell; EVs; lncRNA; Tcf21
MeSH headings : Mice; Animals; Swine; RNA, Long Noncoding / genetics; RNA, Long Noncoding / metabolism; RNA, Antisense / genetics; RNA, Antisense / metabolism; Ventricular Remodeling; Myocardial Infarction / genetics; Myocardial Infarction / therapy; Myocardial Infarction / metabolism; Fibrosis; Demethylation
TL;DR: Novel mechanisms underlying EV therapy for improving adverse remodelling are established and a lncRNA therapy for cardiac fibrosis is proposed, which could be a promising way to treat myocardial fibrosis. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: April 4, 2023

2022 journal article

Inhalable dry powder mRNA vaccines based on extracellular vesicles

Matter, 5(9), 2960–2974.

By: K. Popowski n , A. Moatti n , G. Scull n, D. Silkstone n, H. Lutz  n, B. López de Juan Abad  n, A. George n , E. Belcher  n ...

TL;DR: The results suggest that extracellular vesicles can serve as an inhaled mRNA drug-delivery system that is superior to synthetic liposomes. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: October 17, 2022

2022 journal article

Intrapericardial Exosome Therapy Dampens Cardiac Injury via Activating Foxo3

CIRCULATION RESEARCH, 131(10), E135–E150.

By: D. Zhu n , S. Liu n, K. Huang n , Z. Wang n, S. Hu n , J. Li n, Z. Li n, K. Cheng n

author keywords: exosomes; immunomodulation; mesesnchymal stem cell; myocardial infarction; regulatory T cell
MeSH headings : Humans; Exosomes / metabolism; Forkhead Box Protein O3 / genetics; Forkhead Box Protein O3 / metabolism; Mesenchymal Stem Cells / metabolism; Myocardial Infarction / pathology; Proto-Oncogene Proteins c-akt / metabolism; Signal Transduction; Heart Injuries / metabolism
TL;DR: A novel mechanism underlying the immunomodulation effects of MSC exosomes is revealed and provides a promising candidate (PP2A/p-Akt/Foxo3 signaling pathway) with a favorable delivery route (intrapericardial injection) for cardiac repair. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 14, 2022

2022 journal article

Nanoparticles functionalized with stem cell secretome and CXCR4-overexpressing endothelial membrane for targeted osteoporosis therapy

JOURNAL OF NANOBIOTECHNOLOGY, 20(1).

By: C. Zhang *, W. Zhang *, D. Zhu n , Z. Li n, Z. Wang n, J. Li n, X. Mei n, W. Xu *, K. Cheng n, B. Zhong *

Contributors: C. Zhang *, W. Zhang *, D. Zhu n , Z. Li n, Z. Wang n, J. Li n, X. Mei n, W. Xu *, K. Cheng n, B. Zhong *

author keywords: Osteoporosis; CXCR4; Secretome; Mesenchymal stem cells; Bone targeting; Nanoparticles
MeSH headings : Animals; Cell Membrane / chemistry; Cell Membrane / metabolism; Disease Models, Animal; Endothelial Cells / chemistry; Endothelial Cells / metabolism; Mesenchymal Stem Cells / chemistry; Mesenchymal Stem Cells / metabolism; Nanoparticle Drug Delivery System; Nanoparticles; Osteoporosis / metabolism; Rats; Receptors, CXCR4 / metabolism; Secretome / metabolism
TL;DR: In a rat model of osteoporosis, MSC-Sec/CXCR4 NP were found to accumulate in bone, and such treatment inhibited osteoclast differentiation while promoting osteogenic proliferation. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 24, 2022

2021 journal article

A Minimally Invasive Exosome Spray Repairs Heart after Myocardial Infarction

ACS NANO, 15(7), 11099–11111.

By: J. Yao *, K. Huang n , D. Zhu n , T. Chen*, Y. Jiang *, J. Zhang *, L. Mi*, H. Xuan * ...

Contributors: J. Yao *, K. Huang n , D. Zhu n , T. Chen*, Y. Jiang *, J. Zhang *, L. Mi*, H. Xuan * ...

author keywords: MSC; exosome; spray; myocardial infarction; heart repair
MeSH headings : Mice; Swine; Animals; Exosomes; Myocardial Infarction / therapy; Mesenchymal Stem Cells; Heart; Disease Models, Animal
TL;DR: In a mouse model of acute myocardial infarction, EXOS improved cardiac function and reduced fibrosis, and promoted endogenous angiomyogenesis in the post-injury heart, indicating that EXOS is a promising strategy to deliver therapeutic exosomes for heart repair. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 23, 2021

2021 journal article

A fluid-powered refillable origami heart pouch for minimally invasive delivery of cell therapies in rats and pigs

MED, 2(11), 1253-+.

By: X. Mei n, D. Zhu n , J. Li n, K. Huang n , S. Hu n , Z. Li n, B. Abad  n, K. Cheng n

Contributors: X. Mei n, D. Zhu n , J. Li n, K. Huang n , S. Hu n , Z. Li n, B. Juan Abad  n, K. Cheng n

MeSH headings : Animals; Cell- and Tissue-Based Therapy; Heart; Mesenchymal Stem Cell Transplantation / methods; Mesenchymal Stem Cells; Myocardial Infarction / surgery; Rats; Swine
TL;DR: A fluid-driven heart pouch with a memory-shaped microfabricated lattice structure inspired by origami allowed minimally invasive delivery of the pouch to the heart with two small incisions and can be refilled multiple times with the therapeutic of choice. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 3, 2021

2021 journal article

A stem cell-derived ovarian regenerative patch restores ovarian function and rescues fertility in rats with primary ovarian insufficiency

THERANOSTICS, 11(18), 8894–8908.

By: S. Zhang n, D. Zhu n , Z. Li n, K. Huang n , S. Hu n , H. Lutz  n, M. Xie n, X. Mei n ...

Contributors: S. Zhang n, D. Zhu n , Z. Li n, K. Huang n , S. Hu n , H. Lutz  n, M. Xie n, X. Mei n ...

author keywords: primary ovarian insufficiency; ovarian regenerative patch; regenerative medicine; mesenchymal stem cells; acellular therapy; fertility
MeSH headings : Animals; Apoptosis; Cell-Derived Microparticles / metabolism; Disease Models, Animal; Female; Hydrogels / pharmacology; Infertility, Female / therapy; Mesenchymal Stem Cell Transplantation / methods; Mesenchymal Stem Cells / metabolism; Ovary / pathology; Primary Ovarian Insufficiency / therapy; Rats; Rats, Sprague-Dawley; Regenerative Medicine / methods; Secretome; Stem Cells / metabolism; Tissue Scaffolds
TL;DR: In a rat model of POI, implantation of ORP rescued fertility by restoring sexual hormone secretion, estrus cycle duration, and follicle development and represents a cell-free, off-the-shelf, and clinically feasible treatment for POI. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 12, 2021

2021 review

All Roads Lead to Rome (the Heart): Cell Retention and Outcomes From Various Delivery Routes of Cell Therapy Products to the Heart

[Review of ]. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 10(8).

By: J. Li n, S. Hu n , D. Zhu n , K. Huang n , X. Mei n, B. Abad  n, K. Cheng n

Contributors: J. Li n, S. Hu n , D. Zhu n , K. Huang n , X. Mei n, B. Abad  n, K. Cheng n

author keywords: cardiac repair; cell delivery; intracoronary; intramyocardial; intrapericardial; intravenous; retention rate
MeSH headings : Animals; Cell- and Tissue-Based Therapy / methods; Heart Diseases / therapy; Humans; Injections
TL;DR: An in‐depth study of primary theories of cell loss, including low efficiency in cell injection, “washout” effects, and cell death, is undertaken and the literature from the past decade that focuses on cell transplantation to the heart using various cell delivery routes is organized. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 10, 2021

2021 journal article

Extruded Mesenchymal Stem Cell Nanovesicles Are Equally Potent to Natural Extracellular Vesicles in Cardiac Repair

ACS APPLIED MATERIALS & INTERFACES, 13(47), 55767–55779.

By: X. Wang  n, S. Hu n , J. Li n, D. Zhu n , Z. Wang n, J. Cores n, K. Cheng n, G. Liu *, K. Huang n 

Contributors: X. Wang  n, S. Hu n , J. Li n, D. Zhu n , Z. Wang n, J. Cores n, K. Cheng n, G. Liu *, K. Huang n 

author keywords: extrusion; nanovesicles; extracellular vesicles; mesenchymal stem cell; ischemia reperfusion injury
MeSH headings : Animals; Disease Models, Animal; Endothelial Cells / drug effects; Endothelial Cells / pathology; Extracellular Vesicles / chemistry; Fibroblasts / drug effects; Fibroblasts / pathology; Mesenchymal Stem Cells / chemistry; Mesenchymal Stem Cells / cytology; Mice; Myocardial Infarction / drug therapy; Myocardial Infarction / pathology; Myocytes, Cardiac / drug effects; Myocytes, Cardiac / pathology; Nanoparticles / chemistry; Particle Size; Surface Properties
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 21, 2022

2021 journal article

Intrapericardial hydrogel injection generates high cell retention and augments therapeutic effects of mesenchymal stem cells in myocardial infarction

CHEMICAL ENGINEERING JOURNAL, 427.

By: J. Li n, Y. Lv *, D. Zhu n , X. Mei n, K. Huang n , X. Wang  n, Z. Li n, S. Zhang n ...

Contributors: J. Li n, Y. Lv *, D. Zhu n , X. Mei n, K. Huang n , X. Wang  n, Z. Li n, S. Zhang n ...

author keywords: Mesenchymal stem cells; Hydrogel; Myocardial infarction; Intrapericardial; Intramyocardial
TL;DR: Intrapericardial cavity injection gave a promising solution for the low retention issue of MSCs in the infarcted heart and the feasibility and safety of IPC injection were demonstrated in a porcine model with minimally invasive procedure. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 3, 2022

2021 journal article

Platelet membrane and stem cell exosome hybrids enhance cellular uptake and targeting to heart injury

NANO TODAY, 39.

By: S. Hu n , X. Wang  n, Z. Li n, D. Zhu n , J. Cores n, Z. Wang n, J. Li n, X. Mei n ...

Contributors: S. Hu n , X. Wang  n, Z. Li n, D. Zhu n , J. Cores n, Z. Wang n, J. Li n, X. Mei n ...

author keywords: Exosomes; Targeting; Myocardial infarction; Platelet membrane; Stem cells
TL;DR: It is found that encapsulation by the platelet membranes induces macropinocytosis, enhancing the cellular uptake of exosomes by endothelial cells and cardiomyocytes strikingly and boosting the cardiac targeting ability of hybrid exosome in a mice model with myocardial infarction injury. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 7, 2021

2020 journal article

A trifunctional contraceptive gel enhances the safety and quality of sexual intercourse

BIOACTIVE MATERIALS, 6(6), 1777–1788.

By: M. Xie n, J. Li n, S. Zhang n, D. Zhu n , X. Mei n, Z. Wang n, X. Cheng n, Z. Li n, S. Wang *, K. Cheng n

Contributors: M. Xie n, J. Li n, S. Zhang n, D. Zhu n , X. Mei n, Z. Wang n, X. Cheng n, Z. Li n, S. Wang *, K. Cheng n

author keywords: Contraceptive; Hydrogel; Anti-viral; Libido; Erectile function
TL;DR: A novel TGN contraceptive gel consisting of three agents: tenofovir, gossypol acetate, and nitroglycerin (TGN) yielded a higher contraceptive success rate than that of the commercial contraceptive gel (Contragel®), and has the added benefits to prevent sexually transmitted diseases and improve male libido and erection function during sexual intercourse. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 6, 2021

2020 review

Advances in biomaterials and regenerative medicine for primary ovarian insufficiency therapy

[Review of ]. BIOACTIVE MATERIALS, 6(7), 1957–1972.

By: S. Zhang n, D. Zhu n , X. Mei n, Z. Li n, J. Li n, M. Xie n, H. Xie, S. Wang *, K. Cheng n

Contributors: S. Zhang n, D. Zhu n , X. Mei n, Z. Li n, J. Li n, M. Xie n, H. Xie, S. Wang *, K. Cheng n

author keywords: Stem cells; Primary ovarian insufficiency; Cell therapy; Biomaterials
TL;DR: A thorough understanding of the work already done can aid in the development of guidelines for future translational applications and clinical trials that aim to cure POI by using regenerative medicine and biomedical engineering strategies. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 6, 2021

2020 review

Engineering better stem cell therapies for treating heart diseases

[Review of ]. ANNALS OF TRANSLATIONAL MEDICINE, 8(8).

By: J. Li n, S. Hu n  & K. Cheng n

author keywords: Stem cell therapy; ischemic heart diseases; bioengineering strategies; clinical translation
TL;DR: This review will provide a brief summary of stem cell therapies for ischemic heart disease, the investigation of mechanisms behind stem-cell based cardiac regeneration and also, what bioengineers can do and have been doing on the translational stage of stem Cell therapies for heart repair. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 26, 2020

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