Works (16)
Updated: April 3rd, 2024 20:00
2021 journal article
Course-based undergraduate research experiences are a viable approach to increase access to research experiences in biology
Journal of Biological Education, 6, 1–15.
author keywords: Undergraduate; research; cure; expanding access; biology
TL;DR:
In comparing student outcomes from four distinct CUREs to outcomes from students engaged in a summer research programme in the biology department at one institution, it is found that students in both experiences self-report comparable gains on all items studied using the Undergraduate Research Student Self-Assessment tool.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: June 28, 2021
2021 journal article
Sugar‐seeking insects as a source of diverse bread‐making yeasts with enhanced attributes
Yeast, 39(1-2), 108–127.
author keywords: baking; bioprospecting; bread; Lachancea; non-conventional yeasts; Saccharomyces
MeSH headings : Animals; Bread; Fermentation; Insecta; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism; Sugars / metabolism; Yeasts
TL;DR:
The results suggest that non‐conventional yeasts have high potential for baking and, more generally, showcase the success of bioprospecting in insects for identifying yeasts relevant for industrial uses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: November 17, 2021
2019 journal article
Complete Genome Sequences of 12 B1 Cluster Mycobacteriophages, Gareth, JangoPhett, Kailash, MichaelPhcott, PhenghisKhan, Phleuron, Phergie, PhrankReynolds, PhrodoBaggins, Phunky, Vaticameos, and Virapocalypse
Microbiology Resource Announcements, 8(8).
Ed(s): J. Dennehy
TL;DR:
Twelve B1 cluster mycobacteriaiophages were isolated from soil samples collected in Philadelphia, PA, USA, using Mycobacterium smegmatis mc2 155 as a host, and were sequenced.
(via Semantic Scholar)
mra.asm.org (publisher PDF)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: March 11, 2019
2018 journal article
Complete Genome Sequence of Cluster J Mycobacteriophage Superphikiman
Genome Announcements, 6(5).
TL;DR:
Superphikiman is a cluster J bacteriophage which was isolated from soil collected in Philadelphia, PA and has a 109,799-bp genome with 239 predicted genes, including 2 tRNA genes.
(via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: December 31, 2018
2017 journal article
An inclusive Research Education Community (iREC): Impact of the SEA-PHAGES program on research outcomes and student learning
Proceedings of the National Academy of Sciences, 114(51), 13531–13536.
author keywords: bacteriophage; genomics; science education; evolution; assessment
MeSH headings : Biomedical Research / education; Biomedical Research / standards; Education, Medical, Undergraduate / methods; Education, Medical, Undergraduate / standards; Female; Humans; Learning; Male; Program Evaluation; Teaching; Universities / standards; Young Adult
TL;DR:
The SEA-PHAGES students show strong gains correlated with persistence relative to those in traditional laboratory courses regardless of academic, ethnic, gender, and socioeconomic profiles.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 19, 2020
2014 journal article
A requirement for Nedd9 in luminal progenitor cells prior to mammary tumorigenesis in MMTV-HER2/ErbB2 mice
Oncogene, 33(4), 411–420.
MeSH headings : Adaptor Proteins, Signal Transducing / genetics; Adaptor Proteins, Signal Transducing / metabolism; Animals; Carcinogenesis / genetics; Carcinogenesis / metabolism; Female; Mammary Neoplasms, Experimental / genetics; Mammary Neoplasms, Experimental / metabolism; Mammary Neoplasms, Experimental / pathology; Mammary Tumor Virus, Mouse; Mice; Mice, Knockout; Neoplasm Invasiveness / genetics; Neoplasm Invasiveness / pathology; Neoplastic Stem Cells / metabolism; Neoplastic Stem Cells / pathology
TL;DR:
Results indicate a functional requirement for NEDD9 in the growth of mammary cancer progenitor cells is required via post-transcriptional regulation of cell signaling, coupled with emerging data indicating a role for Nedd9 in progenitors cell populations during the morphogenesis of other tissues.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: March 1, 2023
2013 journal article
Cilia and cilia-associated proteins in cancer
Drug Discovery Today: Disease Mechanisms, 10(3-4), e135–e142.
TL;DR:
Mechanisms by which changes in cilia can contribute to the formation and growth of tumors are discussed, and the cancer-relevance of cilia-dependent signaling pathways and proteins including mTOR, VHL, TSC, WNT, Aurora-A, NEDD9, and Hedgehog are emphasized.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: March 1, 2023
2013 chapter
NEDD9
In J. L. Marshall (Ed.), Cancer Therapeutic Targets.
Ed(s): J. Marshall
Sources: Crossref, NC State University Libraries
Added: March 1, 2023
2009 journal article
CAS proteins in normal and pathological cell growth control
Cellular and Molecular Life Sciences, 67(7), 1025–1048.
MeSH headings : Adaptor Proteins, Signal Transducing / metabolism; Adaptor Proteins, Signal Transducing / physiology; Apoptosis; Cell Movement; Crk-Associated Substrate Protein / chemistry; Crk-Associated Substrate Protein / metabolism; Crk-Associated Substrate Protein / physiology; Humans; Neoplasms / metabolism; Phosphoproteins / metabolism; Phosphoproteins / physiology
TL;DR:
This review will explore the roles of the CAS proteins in normal and pathological states in the context of the many mechanistic insights into CAS protein function that have emerged in the past decade.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: March 2, 2023
2009 journal article
NEDD9 Promotes Oncogenic Signaling in Mammary Tumor Development
Cancer Research, 69(18), 7198–7206.
MeSH headings : Adaptor Proteins, Signal Transducing; Animals; Cell Movement / physiology; Cell Transformation, Neoplastic / genetics; Cell Transformation, Neoplastic / metabolism; Cell Transformation, Neoplastic / pathology; Female; Focal Adhesion Kinase 1 / metabolism; Mammary Neoplasms, Experimental / genetics; Mammary Neoplasms, Experimental / metabolism; Mammary Neoplasms, Experimental / pathology; Mammary Tumor Virus, Mouse / genetics; Mice; Mice, Inbred C57BL; Proteins / genetics; Proteins / metabolism; Signal Transduction
TL;DR:
It is shown that the Nedd9-null genetic background significantly limits mammary tumor initiation in the MMTV-polyoma virus middle T genetic model and suggests that NEDD9 expression may provide a biomarker for tumor aggressiveness.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: March 1, 2023
2008 journal article
Disruption of crosstalk between the fatty acid synthesis and proteasome pathways enhances unfolded protein response signaling and cell death
Molecular Cancer Therapeutics, 7(12), 3816–3824.
MeSH headings : Antigens, Differentiation / metabolism; Cell Cycle Proteins / metabolism; Cell Death; Cell Line, Tumor; DNA-Binding Proteins / metabolism; Dose-Response Relationship, Drug; Fatty Acid Synthase, Type I / metabolism; Fatty Acid Synthase, Type I / physiology; Fatty Acids / metabolism; Humans; Male; Models, Biological; Prostatic Neoplasms / drug therapy; Prostatic Neoplasms / pathology; Proteasome Endopeptidase Complex / metabolism; Protein Denaturation; Protein Phosphatase 1; Regulatory Factor X Transcription Factors; Signal Transduction; Transcription Factors / metabolism; Ubiquitin / metabolism
TL;DR:
The data support the concept that the UPR balance between adaptive to stress signaling can be exploited to mediate increased cell death and suggests novel applications of FASN inhibitors for clinical use.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: March 1, 2023
2008 chapter book
Fatty Acid Synthase Activity in Tumor Cells
MeSH headings : Animals; Antineoplastic Agents / pharmacology; Cell Cycle / drug effects; Enzyme Inhibitors / pharmacology; Fatty Acid Synthases / antagonists & inhibitors; Fatty Acid Synthases / metabolism; Gene Expression Regulation, Developmental; Gene Expression Regulation, Neoplastic; Humans; Neoplasms / enzymology; Palmitic Acid / metabolism; Signal Transduction; Up-Regulation
TL;DR:
Pharmacological blockade of FASN activity has identified a pleiotropic role for FASn in mediating aspects of proliferation, growth and survival, and a clearer understanding of the role of F ASN in tumor cells has been developed.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: March 2, 2023
2007 journal article
Inhibition of Fatty Acid Synthase Induces Endoplasmic Reticulum Stress in Tumor Cells
Cancer Research, 67(3), 1262–1269.
MeSH headings : Activating Transcription Factor 4 / biosynthesis; Activating Transcription Factor 4 / genetics; Animals; Cell Line, Tumor; DNA-Binding Proteins / biosynthesis; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Drug Interactions; Endoplasmic Reticulum / drug effects; Endoplasmic Reticulum / enzymology; Endoplasmic Reticulum / genetics; Endoplasmic Reticulum Chaperone BiP; Enzyme Inhibitors / pharmacology; Eukaryotic Initiation Factor-2B / metabolism; Fatty Acid Synthases / antagonists & inhibitors; Fatty Acid Synthases / biosynthesis; HT29 Cells; HeLa Cells; Heat-Shock Proteins / biosynthesis; Heat-Shock Proteins / genetics; Humans; Lactones / pharmacology; Male; Mice; Molecular Chaperones / biosynthesis; Molecular Chaperones / genetics; Nuclear Proteins / biosynthesis; Nuclear Proteins / genetics; Nuclear Proteins / metabolism; Orlistat; Phosphorylation; Prostatic Neoplasms / drug therapy; Prostatic Neoplasms / enzymology; Regulatory Factor X Transcription Factors; Thapsigargin / pharmacology; Transcription Factor CHOP / biosynthesis; Transcription Factor CHOP / genetics; Transcription Factors; eIF-2 Kinase / metabolism
TL;DR:
The results provide the first evidence that FAS inhibitors induce ER stress and establish an important mechanistic link between FAS activity and ER function.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: March 2, 2023
2006 journal article
Fatty acid synthase: a novel target for antiglioma therapy
British Journal of Cancer, 95(7), 869–878.
MeSH headings : Animals; Apoptosis / drug effects; Apoptosis / physiology; Astrocytes / drug effects; Base Sequence; Blotting, Western; Brain / enzymology; Brain Neoplasms / drug therapy; Brain Neoplasms / enzymology; Cell Line, Tumor; Cerulenin / pharmacology; Collagen Type XI / drug effects; Collagen Type XI / metabolism; Dose-Response Relationship, Drug; Enzyme Inhibitors / pharmacology; Fatty Acid Synthases / drug effects; Fatty Acid Synthases / genetics; Fatty Acid Synthases / metabolism; Flow Cytometry; Glioma / drug therapy; Glioma / enzymology; Humans; Molecular Sequence Data; Proto-Oncogene Proteins c-bcl-2 / metabolism; RNA, Small Interfering; Radiation Tolerance / drug effects; Rats; Transfection
TL;DR:
It is suggested that FAS might be a novel target for antiglioma therapy after it was found that RNAi-mediated knockdown of FAS leading to reduced FAS enzymatic activity was associated with decreased glioma cell viability.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: March 2, 2023
2005 journal article
Conditional expression of the mutant Ki- rasG12C allele results in formation of benign lung adenomas: development of a novel mouse lung tumor model
Carcinogenesis, 26(12), 2196–2206.
MeSH headings : Adenoma / etiology; Adenoma / metabolism; Adenoma / pathology; Alleles; Animals; Bronchi; Cell Transformation, Neoplastic; Doxycycline / pharmacology; Genes, ras / genetics; Genes, ras / physiology; Humans; Hyperplasia / etiology; Hyperplasia / metabolism; Hyperplasia / pathology; Intracellular Signaling Peptides and Proteins; Lung Neoplasms / etiology; Lung Neoplasms / metabolism; Lung Neoplasms / pathology; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinase 1 / metabolism; Mitogen-Activated Protein Kinase 3 / metabolism; Mutation / genetics; Phosphorylation; Protein Serine-Threonine Kinases / metabolism; Pulmonary Alveoli / cytology; Pulmonary Alveoli / metabolism; Ribosomal Protein S6 Kinases, 90-kDa / metabolism; Signal Transduction; Tumor Cells, Cultured; p38 Mitogen-Activated Protein Kinases / metabolism; ral GTP-Binding Proteins
TL;DR:
A novel mouse lung tumor model demonstrating benign tumor development in the absence of tumor progression is described, which will provide a new tool for understanding the early stages of lung tumor pathogenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: March 2, 2023
2002 journal article
Positive results in association studies are associated with departure from Hardy-Weinberg equilibrium: hint for genotyping error?
Human Genetics, 111(6), 573–574.
MeSH headings : Genotype; Humans; Polymorphism, Single Nucleotide; Sequence Analysis, DNA
Sources: Crossref, NC State University Libraries
Added: March 2, 2023
Employment
Updated: August 7th, 2023 15:26
2016 - present
North Carolina State University Raleigh, North Carolina, US
Assistant Professor of Teaching
Biological Sciences
2013 - 2016
Drexel University Philadelphia, Pennsylvania, US
Assistant Teaching Professor
Biology
2012 - 2013
Bryn Mawr College Bryn Mawr, Pennsylvania, US
Lecturer
Biology
2008 - 2012
Fox Chase Cancer Center Philadelphia, PA, US
Postdoctoral Fellow
Education
Updated: August 7th, 2023 15:28
2003 - 2008
Wake Forest University Winston-Salem, North Carolina, US
Ph.D.
Cancer Biology
1999 - 2003
Salem College Winston-Salem, North Carolina, US
B.A. in Biology
Biology
Funding History
Funding history based on the linked ORCID record. Updated: August 23rd, 2023 11:17
grant
September 1, 2010 - October 4, 2011
Interactions between NEDD9, AURKA, and p53 in mammary tumor development
National Cancer Institute
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