Works (16)

Updated: August 7th, 2023 21:16

2021 journal article

Course-based undergraduate research experiences are a viable approach to increase access to research experiences in biology

Journal of Biological Education, 6, 1–15.

By: K. Smith*, E. Waddell*, A. Dean*, S. Anandan*, S. Gurney*, K. Kabnick*, J. Little n, M. McDonald* ...

co-author countries: United States of America 🇺🇸
author keywords: Undergraduate; research; cure; expanding access; biology
Sources: Web Of Science, Crossref, ORCID
Added: June 28, 2021

2021 journal article

Sugar‐seeking insects as a source of diverse bread‐making yeasts with enhanced attributes

Yeast, 39(1-2), 108–127.

By: A. Madden n, C. Lahue n, C. Gordy n, J. Little n, L. Nichols n, M. Calvert n, R. Dunn n, C. Smukowski Heil n

co-author countries: United States of America 🇺🇸
author keywords: baking; bioprospecting; bread; Lachancea; non-conventional yeasts; Saccharomyces
MeSH headings : Animals; Bread; Fermentation; Insecta; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism; Sugars / metabolism; Yeasts
Sources: Web Of Science, Crossref, ORCID
Added: November 17, 2021

2019 journal article

Complete Genome Sequences of 12 B1 Cluster Mycobacteriophages, Gareth, JangoPhett, Kailash, MichaelPhcott, PhenghisKhan, Phleuron, Phergie, PhrankReynolds, PhrodoBaggins, Phunky, Vaticameos, and Virapocalypse

Microbiology Resource Announcements, 8(8).

By: K. Apellido*, D. Balchander*, M. Erlich*, J. Gocal*, W. Gocal*, S. Haile*, A. Kang*, S. Koduri* ...

co-author countries: United States of America 🇺🇸

Ed(s): J. Dennehy

Sources: Web Of Science, Crossref, ORCID
Added: March 11, 2019

2018 journal article

Complete Genome Sequence of Cluster J Mycobacteriophage Superphikiman

Genome Announcements, 6(5).

By: P. Pradhan*, S. Nako*, T. Tran*, L. Aluri*, D. Anandarajan*, N. Betini*, S. Bhatt*, S. Chengalvala* ...

co-author countries: United States of America 🇺🇸
Sources: Web Of Science, Crossref, ORCID
Added: December 31, 2018

2017 journal article

An inclusive Research Education Community (iREC): Impact of the SEA-PHAGES program on research outcomes and student learning

Proceedings of the National Academy of Sciences, 114(51), 13531–13536.

By: D. Hanauer*, M. Graham*, L. Betancur*, A. Bobrownicki*, S. Cresawn*, R. Garlena*, D. Jacobs-Sera*, N. Kaufmann* ...

co-author countries: United States of America 🇺🇸
author keywords: bacteriophage; genomics; science education; evolution; assessment
MeSH headings : Biomedical Research / education; Biomedical Research / standards; Education, Medical, Undergraduate / methods; Education, Medical, Undergraduate / standards; Female; Humans; Learning; Male; Program Evaluation; Teaching; Universities / standards; Young Adult
Sources: Crossref, ORCID
Added: January 19, 2020

2014 journal article

A requirement for Nedd9 in luminal progenitor cells prior to mammary tumorigenesis in MMTV-HER2/ErbB2 mice

Oncogene, 33(4), 411–420.

By: J. Little*, V. Serzhanova*, E. Izumchenko*, B. Egleston*, E. Parise*, A. Klein-Szanto*, G. Loudon*, M. Shubina* ...

co-author countries: Japan 🇯🇵 United States of America 🇺🇸
MeSH headings : Adaptor Proteins, Signal Transducing / genetics; Adaptor Proteins, Signal Transducing / metabolism; Animals; Carcinogenesis / genetics; Carcinogenesis / metabolism; Female; Mammary Neoplasms, Experimental / genetics; Mammary Neoplasms, Experimental / metabolism; Mammary Neoplasms, Experimental / pathology; Mammary Tumor Virus, Mouse; Mice; Mice, Knockout; Neoplasm Invasiveness / genetics; Neoplasm Invasiveness / pathology; Neoplastic Stem Cells / metabolism; Neoplastic Stem Cells / pathology
Sources: Crossref, ORCID
Added: March 1, 2023

2013 journal article

Cilia and cilia-associated proteins in cancer

Drug Discovery Today: Disease Mechanisms, 10(3-4), e135–e142.

By: T. Seeger-Nukpezah*, J. Little*, V. Serzhanova* & E. Golemis*

co-author countries: United States of America 🇺🇸
Sources: Crossref, ORCID
Added: March 1, 2023

2013 chapter

NEDD9

In J. L. Marshall (Ed.), Cancer Therapeutic Targets.

By: J. Little* & E. Golemis

Ed(s): J. Marshall

Sources: Crossref, ORCID
Added: March 1, 2023

2009 journal article

CAS proteins in normal and pathological cell growth control

Cellular and Molecular Life Sciences, 67(7), 1025–1048.

By: N. Tikhmyanova*, J. Little* & E. Golemis*

co-author countries: United States of America 🇺🇸
MeSH headings : Adaptor Proteins, Signal Transducing / metabolism; Adaptor Proteins, Signal Transducing / physiology; Apoptosis; Cell Movement; Crk-Associated Substrate Protein / chemistry; Crk-Associated Substrate Protein / metabolism; Crk-Associated Substrate Protein / physiology; Humans; Neoplasms / metabolism; Phosphoproteins / metabolism; Phosphoproteins / physiology
Sources: Crossref, ORCID
Added: March 2, 2023

2009 journal article

NEDD9 Promotes Oncogenic Signaling in Mammary Tumor Development

Cancer Research, 69(18), 7198–7206.

By: E. Izumchenko*, M. Singh, O. Plotnikova*, N. Tikhmyanova*, J. Little*, I. Serebriiskii, S. Seo*, M. Kurokawa* ...

co-author countries: Israel 🇮🇱 Japan 🇯🇵 Russian Federation 🇷🇺 Slovakia 🇸🇰 United States of America 🇺🇸
MeSH headings : Adaptor Proteins, Signal Transducing; Animals; Cell Movement / physiology; Cell Transformation, Neoplastic / genetics; Cell Transformation, Neoplastic / metabolism; Cell Transformation, Neoplastic / pathology; Female; Focal Adhesion Kinase 1 / metabolism; Mammary Neoplasms, Experimental / genetics; Mammary Neoplasms, Experimental / metabolism; Mammary Neoplasms, Experimental / pathology; Mammary Tumor Virus, Mouse / genetics; Mice; Mice, Inbred C57BL; Proteins / genetics; Proteins / metabolism; Signal Transduction
Sources: Crossref, ORCID
Added: March 1, 2023

2008 journal article

Disruption of crosstalk between the fatty acid synthesis and proteasome pathways enhances unfolded protein response signaling and cell death

Molecular Cancer Therapeutics, 7(12), 3816–3824.

By: J. Little*, F. Wheeler*, C. Koumenis* & S. Kridel*

co-author countries: United States of America 🇺🇸
MeSH headings : Antigens, Differentiation / metabolism; Cell Cycle Proteins / metabolism; Cell Death; Cell Line, Tumor; DNA-Binding Proteins / metabolism; Dose-Response Relationship, Drug; Fatty Acid Synthase, Type I / metabolism; Fatty Acid Synthase, Type I / physiology; Fatty Acids / metabolism; Humans; Male; Models, Biological; Prostatic Neoplasms / drug therapy; Prostatic Neoplasms / pathology; Proteasome Endopeptidase Complex / metabolism; Protein Denaturation; Protein Phosphatase 1; Regulatory Factor X Transcription Factors; Signal Transduction; Transcription Factors / metabolism; Ubiquitin / metabolism
Sources: Crossref, ORCID
Added: March 1, 2023

2008 chapter book

Fatty Acid Synthase Activity in Tumor Cells

By: J. Little* & S. Kridel*

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Antineoplastic Agents / pharmacology; Cell Cycle / drug effects; Enzyme Inhibitors / pharmacology; Fatty Acid Synthases / antagonists & inhibitors; Fatty Acid Synthases / metabolism; Gene Expression Regulation, Developmental; Gene Expression Regulation, Neoplastic; Humans; Neoplasms / enzymology; Palmitic Acid / metabolism; Signal Transduction; Up-Regulation
Sources: Crossref, ORCID
Added: March 2, 2023

2007 journal article

Inhibition of Fatty Acid Synthase Induces Endoplasmic Reticulum Stress in Tumor Cells

Cancer Research, 67(3), 1262–1269.

By: J. Little*, F. Wheeler, D. Fels, C. Koumenis* & S. Kridel

co-author countries: United States of America 🇺🇸
MeSH headings : Activating Transcription Factor 4 / biosynthesis; Activating Transcription Factor 4 / genetics; Animals; Cell Line, Tumor; DNA-Binding Proteins / biosynthesis; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Drug Interactions; Endoplasmic Reticulum / drug effects; Endoplasmic Reticulum / enzymology; Endoplasmic Reticulum / genetics; Endoplasmic Reticulum Chaperone BiP; Enzyme Inhibitors / pharmacology; Eukaryotic Initiation Factor-2B / metabolism; Fatty Acid Synthases / antagonists & inhibitors; Fatty Acid Synthases / biosynthesis; HT29 Cells; HeLa Cells; Heat-Shock Proteins / biosynthesis; Heat-Shock Proteins / genetics; Humans; Lactones / pharmacology; Male; Mice; Molecular Chaperones / biosynthesis; Molecular Chaperones / genetics; Nuclear Proteins / biosynthesis; Nuclear Proteins / genetics; Nuclear Proteins / metabolism; Orlistat; Phosphorylation; Prostatic Neoplasms / drug therapy; Prostatic Neoplasms / enzymology; Regulatory Factor X Transcription Factors; Thapsigargin / pharmacology; Transcription Factor CHOP / biosynthesis; Transcription Factor CHOP / genetics; Transcription Factors; eIF-2 Kinase / metabolism
Sources: Crossref, ORCID
Added: March 2, 2023

2006 journal article

Fatty acid synthase: a novel target for antiglioma therapy

British Journal of Cancer, 95(7), 869–878.

By: W. Zhao*, S. Kridel*, A. Thorburn*, M. Kooshki*, J. Little*, S. Hebbar*, M. Robbins*

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Apoptosis / drug effects; Apoptosis / physiology; Astrocytes / drug effects; Base Sequence; Blotting, Western; Brain / enzymology; Brain Neoplasms / drug therapy; Brain Neoplasms / enzymology; Cell Line, Tumor; Cerulenin / pharmacology; Collagen Type XI / drug effects; Collagen Type XI / metabolism; Dose-Response Relationship, Drug; Enzyme Inhibitors / pharmacology; Fatty Acid Synthases / drug effects; Fatty Acid Synthases / genetics; Fatty Acid Synthases / metabolism; Flow Cytometry; Glioma / drug therapy; Glioma / enzymology; Humans; Molecular Sequence Data; Proto-Oncogene Proteins c-bcl-2 / metabolism; RNA, Small Interfering; Radiation Tolerance / drug effects; Rats; Transfection
Sources: Crossref, ORCID
Added: March 2, 2023

2005 journal article

Conditional expression of the mutant Ki- rasG12C allele results in formation of benign lung adenomas: development of a novel mouse lung tumor model

Carcinogenesis, 26(12), 2196–2206.

By: H. Floyd*, C. Farnsworth, N. Kock, M. Mizesko, J. Little*, S. Dance, J. Everitt, J. Tichelaar, J. Whitsett, M. Miller*

co-author countries: United States of America 🇺🇸
MeSH headings : Adenoma / etiology; Adenoma / metabolism; Adenoma / pathology; Alleles; Animals; Bronchi; Cell Transformation, Neoplastic; Doxycycline / pharmacology; Genes, ras / genetics; Genes, ras / physiology; Humans; Hyperplasia / etiology; Hyperplasia / metabolism; Hyperplasia / pathology; Intracellular Signaling Peptides and Proteins; Lung Neoplasms / etiology; Lung Neoplasms / metabolism; Lung Neoplasms / pathology; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinase 1 / metabolism; Mitogen-Activated Protein Kinase 3 / metabolism; Mutation / genetics; Phosphorylation; Protein Serine-Threonine Kinases / metabolism; Pulmonary Alveoli / cytology; Pulmonary Alveoli / metabolism; Ribosomal Protein S6 Kinases, 90-kDa / metabolism; Signal Transduction; Tumor Cells, Cultured; p38 Mitogen-Activated Protein Kinases / metabolism; ral GTP-Binding Proteins
Sources: Crossref, ORCID
Added: March 2, 2023

2002 journal article

Positive results in association studies are associated with departure from Hardy-Weinberg equilibrium: hint for genotyping error?

Human Genetics, 111(6), 573–574.

By: J. Xu*, A. Turner*, J. Little*, E. Bleecker* & D. Meyers*

co-author countries: United States of America 🇺🇸
MeSH headings : Genotype; Humans; Polymorphism, Single Nucleotide; Sequence Analysis, DNA
Sources: Crossref, ORCID
Added: March 2, 2023

Employment

Updated: August 7th, 2023 15:26

2016 - present

North Carolina State University Raleigh, North Carolina, US
Assistant Professor of Teaching Biological Sciences

2013 - 2016

Drexel University Philadelphia, Pennsylvania, US
Assistant Teaching Professor Biology

2012 - 2013

Bryn Mawr College Bryn Mawr, Pennsylvania, US
Lecturer Biology

2008 - 2012

Fox Chase Cancer Center Philadelphia, PA, US
Postdoctoral Fellow

Education

Updated: August 7th, 2023 15:28

2003 - 2008

Wake Forest University Winston-Salem, North Carolina, US
Ph.D. Cancer Biology

1999 - 2003

Salem College Winston-Salem, North Carolina, US
B.A. in Biology Biology

Funding History

Funding history based on the linked ORCID record. Updated: August 23rd, 2023 11:17

grant September 1, 2010 - October 4, 2011
Interactions between NEDD9, AURKA, and p53 in mammary tumor development
National Cancer Institute