@article{willcox_belanger_burton_yu_ueda_visser_skorupski_stern_2020, title={Intramuscular Diphenhydramine Does Not Affect Acute Doxorubicin Infusion-Related Arrhythmia Number or Severity in a Prospective Crossover Study in Canine Lymphoma: A Pilot Study}, volume={7}, ISSN={["2297-1769"]}, DOI={10.3389/fvets.2020.00368}, abstractNote={Background: Doxorubicin (DOX) is one of the most effective chemotherapeutics for canine high-grade lymphoma. In addition to dose-dependent chronic cardiotoxicity, DOX can trigger acute cardiac arrhythmias during drug infusion. Diphenhydramine premedication is commonly used, as histamine release is a proposed mechanism for DOX-associated arrhythmogenesis. Hypothesis/Objectives: The study objectives were to evaluate the incidence and severity of DOX infusion-related cardiac arrhythmias in dogs with high-grade lymphoma and evaluate the effect of diphenhydramine premedication on arrhythmia frequency and severity during and after DOX infusion. Animals: Twenty-two client-owned dogs with cytologically/histopathologically confirmed high-grade lymphoma were recruited, of which 19 were enrolled and 9 completed the study. Methods: Dogs were screened by echocardiogram and concurrent electrocardiogram for this randomized prospective crossover study. Group A received no premedication for DOX #1 and was premedicated with diphenhydramine for DOX #2; Group B received diphenhydramine with DOX #1 and no premedication for DOX #2. For both visits, Holter monitor data were collected for 1 h pre-DOX and 3 h post-DOX administration. Results: Nineteen dogs were enrolled and 9 dogs [Group A (5), Group B (4)] completed the protocol. There was no statistical difference between the DOX alone and DOX + diphenhydramine when evaluating the total number of ventricular premature complexes (VPCs, P = 0.34), change in VPCs/hour (P = 0.25), total number of atrial premature complexes (APCs, P = 0.5), change in APCs/hour (P = 0.06), or ventricular arrhythmia severity score (P > 0.99). Conclusions and clinical importance: This study demonstrates that in these dogs with rigorous pretreatment cardiovascular screening, DOX infusion did not induce significant arrhythmias. Furthermore, these data suggest that, with this screening approach, diphenhydramine may not alter the arrhythmia number or severity in canine DOX recipients.}, journal={FRONTIERS IN VETERINARY SCIENCE}, author={Willcox, Jennifer Lindley and Belanger, Catherine and Burton, Jenna Hart and Yu, Lydia and Ueda, Yu and Visser, Lance C. and Skorupski, Katherine and Stern, Joshua A.}, year={2020}, month={Jul} }
 @article{willcox_hammett-stabler_hauck_2016, title={Serum 25-hydroxyvitamin D concentrations in dogs with osteosarcoma do not differ from those of age- and weight-matched control dogs}, volume={217}, ISSN={["1532-2971"]}, DOI={10.1016/j.tvjl.2016.10.005}, abstractNote={Vitamin D concentrations show an inverse correlation with incidence of certain tumors in people and dogs. Additionally, human osteosarcoma has been associated with dysregulation of vitamin D-dependent pathways. The study objective was to compare serum 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 in 20 dogs with osteosarcoma to age- and weight-matched control dogs. We hypothesized that dogs with osteosarcoma would have lower serum 25-hydroxyvitamin D than control dogs. The mean 25-hydroxyvitamin D3 concentrations for dogs with osteosarcoma and matched-controls were 34.95 ng/mL and 33.85 ng/mL, respectively (P = 0.784). Based on these data, 25-hydroxyvitamin D insufficiency might not be important in the pathogenesis of canine osteosarcoma.}, journal={VETERINARY JOURNAL}, author={Willcox, Jennifer L. and Hammett-Stabler, Catherine and Hauck, Marlene L.}, year={2016}, month={Nov}, pages={132–133} }
 @article{uchiumi_stowe_devanna_willcox_neel_2014, title={Pathology in Practice}, volume={245}, ISSN={0003-1488}, url={http://dx.doi.org/10.2460/javma.245.8.893}, DOI={10.2460/javma.245.8.893}, abstractNote={A 3-year-old castrated male American Cocker Spaniel was evaluated at the North Carolina State University Veterinary Health Complex Small Animal Emergency Service because of a sudden onset of signs of pain.The dog had a 2-month history of diarrhea, which began as diarrhea of small bowel origin and progressed after 1.5 months to diarrhea of large bowel origin, and a 1-week history of decreased appetite.}, number={8}, journal={Journal of the American Veterinary Medical Association}, publisher={American Veterinary Medical Association (AVMA)}, author={Uchiumi, Kaori and Stowe, Devorah Marks and DeVanna, Justin C. and Willcox, Jennifer L. and Neel, Jennifer A.}, year={2014}, month={Oct}, pages={893–895} }