Works (28)

Updated: April 5th, 2024 02:57

2024 journal article

Flunixin meglumine tissue residues after intravenous administration in goats

FRONTIERS IN VETERINARY SCIENCE, 10.

By: C. Giles n, F. Ferdous n, J. Halleran n, J. Yeatts n, R. Baynes n & D. Mzyk n

author keywords: flunixin; goat; residues; tolerance limit method; withdrawal interval; withdrawal time
TL;DR: Since any detection of flunixin residues at slaughter found in goat tissues is considered a violative residue, a conservative withdrawal interval of 17 days was calculated to ensure levels of flunixin fell below the regulatory limits of detection in liver, kidney, and muscle tissues. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: February 12, 2024

2024 journal article

Pharmacokinetics of intravenously and trans-dermally administered fluralaner in healthy laying shaver hens: fluralaner in chickens

POULTRY SCIENCE, 103(3).

By: B. Elliot n, H. Enomoto n, O. Petritz n, R. Crespo n, J. Yeatts n, I. Fricke n, A. Singleton n, A. Thomson n, R. Baynes n

author keywords: fluralaner; LC/MS; plasma; white shaver hen; pharmacokinetics
TL;DR: Investigation of the plasma fluralaner pharmacokinetic profile of intravenous and transdermal routes and apparent bioavailability of fluralaner administered trans-dermally in healthy shaver hens found it important to understand the pharmacokinetic profile could be useful in determining the appropriate treatment strategy. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: March 25, 2024

2023 journal article

Pharmacokinetics of fluralaner as a systemic drug to control infestations of the common bed bug, <i>Cimex lectularius</i>, in poultry facilities

PARASITES & VECTORS, 16(1).

By: M. Gonzalez-Morales n, A. Thomson n, J. Yeatts n, H. Enomoto n, A. Haija n, R. Santangelo n, O. Petritz n, R. Crespo n, C. Schal n, R. Baynes n

author keywords: Cimex; Bed bugs; Fluralaner; Pharmacokinetics; Poultry; Ectoparasites
TL;DR: Fluralaner appears to be a promising candidate for bed bug control in poultry farms, with a treatment effect lasting at least 28 days, and quantifiable in the hens’ plasma for at least28 days post-treatment. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: September 22, 2023

2022 article

Control of ticks on horses using abamectin-impregnated ear tags. A pharmacokinetic and pharmacodynamic study

Werners, A., Karasek, I., Butler, C., Yeatts, J., Enomoto, H., & Baynes, R. (2022, June 28). JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS.

By: A. Werners*, I. Karasek*, C. Butler*, J. Yeatts n, H. Enomoto n & R. Baynes n

author keywords: abamectin; horse; pharmacokinetics; skin; ticks
MeSH headings : Animals; Cattle; Cattle Diseases; Ear, External; Horse Diseases / drug therapy; Horse Diseases / prevention & control; Horses; Ivermectin / analogs & derivatives; Tick Infestations / drug therapy; Tick Infestations / prevention & control; Tick Infestations / veterinary; Ticks
TL;DR: A practical and affordable prevention of tick infestation by using abamectin-impregnated cattle ear tags affixed to a safety collar is described and results show that abamECTin distributes across horse skin from the site of application and its associated effectiveness in reducing the tick burden. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: July 5, 2022

2022 journal article

The pharmacokinetics of transdermal flunixin in lactating dairy goats

JOURNAL OF DAIRY SCIENCE, 105(1), 549–559.

By: E. Meira n, E. Wiloch n, E. Nixon n, J. Yeatts n, F. Sheela n, G. Smith n, R. Baynes n

author keywords: transdermal flunixin; goat; pharmacokinetics; drug residue; milk
MeSH headings : Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cattle; Clonixin / analogs & derivatives; Female; Goats; Lactation; Milk / chemistry
TL;DR: Evaluated the pharmacokinetics of transdermal flunixin in dairy goats to determine a milk withdrawal interval (WDI) to avoid violative residue contamination in the food supply and propose safe residue levels in goat milk provides a milk WDI of 60 h using the US Food and Drug Administration tolerance limit method. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: October 17, 2021

2021 journal article

EVALUATION OF THE PHARMACOKINETIC BEHAVIOR OF TULATHROMYCIN (DRAXXIN) IN FLORIDA MANATEES (TRICHECHUS MANATUS LATIROSTRIS) UNDERGOING MEDICAL REHABILITATION

JOURNAL OF ZOO AND WILDLIFE MEDICINE, 52(3), 880–885.

By: L. Smith, C. Bublitz, E. Nixon*, J. Yeatts*, R. Ball & R. Baynes*

MeSH headings : Animals; Animals, Wild; Cattle; Disaccharides; Heterocyclic Compounds; Horses; Swine; Trichechus; Trichechus manatus
TL;DR: The pharmacokinetic behavior of tulathromycin in Florida manatees can be used to optimize dosage regimens in this species, and this antibiotic has also been used in manatee with positive clinical outcomes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: October 2, 2021

2021 journal article

In vivo assessment of a delayed release formulation of larazotide acetate indicated for celiac disease using a porcine model

PLOS ONE, 16(4).

By: H. Enomoto n, J. Yeatts n, L. Carbajal n, B. Krishnan, J. Madan, S. Laumas, A. Blikslager n, K. Messenger n

MeSH headings : Administration, Oral; Animals; Celiac Disease / drug therapy; Drug Liberation; Duodenum / metabolism; Jejunum / metabolism; Oligopeptides / administration & dosage; Oligopeptides / pharmacokinetics; Oligopeptides / therapeutic use; Swine
TL;DR: The data shows that LA is available in detectable concentrations at the site of CeD, with a sensitive liquid chromatography/tandem mass spectrometry method developed to quantify LA concentrations in porcine intestinal fluid samples. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: May 17, 2021

2020 journal article

Plasma, urine and tissue concentrations of Flunixin and Meloxicam in Pigs

BMC VETERINARY RESEARCH, 16(1).

By: E. Nixon n, T. Mays*, P. Routh n, J. Yeatts n, V. Fajt*, T. Hairgrove*, R. Baynes n

author keywords: Pig; Flunixin; Meloxicam; Pharmacokinetics; NSAIDs; Residue; Urine; Show
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Clonixin / analogs & derivatives; Clonixin / blood; Clonixin / pharmacokinetics; Clonixin / urine; Half-Life; Injections, Intramuscular / veterinary; Kidney / chemistry; Liver / chemistry; Male; Meloxicam / blood; Meloxicam / pharmacokinetics; Meloxicam / urine; Sus scrofa
TL;DR: The data suggest that pigs given a single intramuscular dose of meloxicam or flunixin are likely to have detectable levels of the parent drug in urine up to 2 days and 5 days, respectively, after the first dose, but unlikely to have tissue residues above the US FDA tolerance or EU MRL following negative urine testing. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: October 12, 2020

2019 journal article

Safety and efficacy of topically applied 0.5% and 1% pirfenidone in a canine model of subconjunctival fibrosis

VETERINARY OPHTHALMOLOGY, 22(4), 502–509.

By: H. Westermeyer n, B. Salmon n, R. Baynes n, J. Yeatts n, A. Khattab n, A. Oh n, F. Mowat n

MeSH headings : Administration, Topical; Animals; Aqueous Humor / drug effects; Conjunctival Diseases / drug therapy; Conjunctival Diseases / pathology; Conjunctival Diseases / veterinary; Disease Models, Animal; Dogs; Drug Implants; Female; Fibrosis / drug therapy; Fibrosis / veterinary; Pyridones / administration & dosage; Pyridones / therapeutic use; Random Allocation
TL;DR: Pfenidone may decrease fibrosis following glaucoma shunt surgery and can potentially be used indefinitely due to minimal side effects. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 5, 2019

2018 journal article

Genetic Parameter Estimates for Metabolizing Two Common Pharmaceuticals in Swine

Frontiers in Genetics, 9(FEB).

By: J. Howard n, M. Ashwell n, R. Baynes n, J. Brooks n, J. Yeatts n & C. Maltecca n

Contributors: J. Howard n, M. Ashwell n, R. Baynes n, J. Brooks n, J. Yeatts n & C. Maltecca n

author keywords: swine; pharmacogenomics; heritability; fenbendazole; flunixin meglumine
TL;DR: A low to moderate proportion of the phenotypic variation in metabolizing fenbendazole and flunixin meglumine drug metabolism was explained by genetics in the current study. (via Semantic Scholar)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2017 journal article

Gene co-expression network analysis identifies porcine genes associated with variation in metabolizing fenbendazole and flunixin meglumine in the liver

Scientific Reports, 7(1).

By: J. Howard n, M. Ashwell n, R. Baynes n, J. Brooks n, J. Yeatts n & C. Maltecca n

Contributors: J. Howard n, M. Ashwell n, R. Baynes n, J. Brooks n, J. Yeatts n & C. Maltecca n

MeSH headings : Animals; Antinematodal Agents / pharmacokinetics; Clonixin / analogs & derivatives; Clonixin / pharmacokinetics; Female; Fenbendazole / pharmacokinetics; Gene Expression; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Liver / drug effects; Liver / metabolism; Male; Sus scrofa / genetics; Transcriptome
TL;DR: The objective was to identify individual genes and gene networks involved in metabolizing fenbendazole (FBZ) and flunixin meglumine (FLU) in swine liver to allow for greater insight into FBZ and FLU metabolism. (via Semantic Scholar)
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2017 journal article

Pharmacokinetic analysis of thymol, carvacrol and diallyl disulfide after intramammary and topical applications in healthy organic dairy cattle

Food Additives & Contaminants: Part A, 34(5), 1–10.

By: S. Mason n, K. Mullen n, K. Anderson n, S. Washburn n, J. Yeatts n & R. Baynes n

author keywords: Mastitis; organic; generally recognised as safe (GRAS); bovine; residue
MeSH headings : Administration, Topical; Allyl Compounds / administration & dosage; Allyl Compounds / pharmacokinetics; Animals; Cattle; Cymenes; Dairying; Disulfides / administration & dosage; Disulfides / pharmacokinetics; Female; Health; Limit of Detection; Mammary Glands, Animal / metabolism; Monoterpenes / administration & dosage; Monoterpenes / pharmacokinetics; Thymol / administration & dosage; Thymol / pharmacokinetics
TL;DR: The plasma pharmacokinetics of three organic mastitis products currently used by organic producers and organic dairy veterinarians are investigated, finding that levels were measurable in the plasma, liver, kidney and fat up to 72 h after the last dose. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref
Added: August 6, 2018

2016 journal article

Development of a HS-SPME-GC-MS/MS Method for the Quantitation of Thymol and Carvacrol in Bovine Matrices and To Determine Residue Depletion in Milk and. Tissues

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 64(41), 7856–7865.

By: S. Armorini*, J. Yeatts*, K. Mullen*, S. Mason*, E. Mehmeti*, K. Anderson*, S. Washburn*, R. Baynes*

author keywords: organic; thymol; carvacrol; milk; bovine tissues; residues
TL;DR: A rapid and sensitive HS-SPME-GC-MS/MS method was developed for the detection of thymol and carvacrol in bovine milk, plasma, liver, kidney, and fat and stability studies showed that both compounds are stable over a 2 month period. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Skin absorption of six performance amines used in metalworking fluids

JOURNAL OF APPLIED TOXICOLOGY, 35(5), 520–528.

By: L. Roux*, J. Brooks n, J. Yeatts n & R. Baynes n

author keywords: skin absorption; metalworking fluids; flow-through diffusion cell; ethanolamines; biocide
MeSH headings : Amines / pharmacokinetics; Animals; Cyclohexylamines / pharmacokinetics; Diphenylamine / pharmacokinetics; Disinfectants / pharmacokinetics; Ethanolamine / pharmacokinetics; Ethanolamines / pharmacokinetics; Gas Chromatography-Mass Spectrometry; Linear Models; Metallurgy; Permeability; Skin Absorption / drug effects; Swine
TL;DR: To determine the absorption of six amines used as corrosion inhibitors and biocides in MWFs, porcine skin flow‐through diffusion cell experiments were conducted and results should help MWF industries choose safer additives for their formulations to protect the health of metalworkers. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Tissue concentrations of sulfamethazine and tetracycline hydrochloride of swine (Sus scrofa domestica) as it relates to withdrawal methods for international export

REGULATORY TOXICOLOGY AND PHARMACOLOGY, 71(3), 590–596.

By: S. Mason*, H. Wu*, J. Yeatts n & R. Baynes n

author keywords: Swine; Tetracycline; Sulfa methazine; Pharmacokinetics; Population; Monte Carlo method; FDA tolerance limit method; Maximum residue limit; Withdrawal interval; Withdrawal time
MeSH headings : Administration, Oral; Age Factors; Animal Husbandry; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacokinetics; Consumer Product Safety; Drug Administration Schedule; Drug Residues / pharmacokinetics; Food Contamination / analysis; Food Supply; Red Meat / analysis; Sulfamethazine / administration & dosage; Sulfamethazine / pharmacokinetics; Sus scrofa / metabolism; Tetracycline / administration & dosage; Tetracycline / pharmacokinetics; Tissue Distribution; Water Supply
TL;DR: The TLM may not always provide adequate WDT for foreign export markets especially when MRLs differ from tolerance levels approved for US markets, however, PopPK methods can provide conservative WDIs in situations with considerable variability in medication exposure such as with administration in water. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Tetracycline Residues in Porcine Stomach after Administration via Drinking Water on a Swine Farm

JOURNAL OF FOOD PROTECTION, 77(1), 122–126.

By: D. Lindquist n, H. Wu*, S. Mason*, J. Yeatts n, J. Brooks n, B. Barlow n, K. Schill n, R. Baynes n

MeSH headings : Animals; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Chromatography, High Pressure Liquid / veterinary; Drug Residues / analysis; Europe; Meat / analysis; Monte Carlo Method; Russia; Stomach / chemistry; Swine; Tetracycline / blood; Tetracycline / pharmacokinetics; United States; Water / chemistry
TL;DR: It is demonstrated that tetracycline residues are still detectable in the stomach tissues after the established United States withdrawal time of 4 days, which may explain why stomach tissues tested in Russia and Europe show positive residues for tetrACYcline, even though the meat may pass inspection here in the United States prior to export. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

The effect of breed and sex on sulfamethazine, enrofloxacin, fenbendazole and flunixin meglumine pharmacokinetic parameters in swine

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 37(6), 531–541.

By: J. Howard n, R. Baynes n, J. Brooks n, J. Yeatts n, B. Bellis n, M. Ashwell n, P. Routh n, A. O'Nan n, C. Maltecca n

Contributors: J. Howard n, R. Baynes n, J. Brooks n, J. Yeatts n, B. Bellis n, M. Ashwell n, P. Routh n, . A.T. O'Nan n, C. Maltecca n

MeSH headings : Animals; Anti-Infective Agents / blood; Anti-Infective Agents / pharmacokinetics; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Antinematodal Agents / blood; Antinematodal Agents / pharmacokinetics; Benzimidazoles / blood; Ciprofloxacin / blood; Clonixin / analogs & derivatives; Clonixin / blood; Clonixin / pharmacokinetics; Enrofloxacin; Female; Fenbendazole / blood; Fenbendazole / pharmacokinetics; Fluoroquinolones / blood; Fluoroquinolones / pharmacokinetics; Male; Sex Factors; Species Specificity; Sulfamethazine / analogs & derivatives; Sulfamethazine / blood; Sulfamethazine / pharmacokinetics; Swine / metabolism
TL;DR: Whether drug clearance differs across genetic backgrounds and sex for sulfamethazine, enrofloxacin, fenbendazole and flunixin meglumine is determined to determine the degree of additive genetic variation utilizing a larger population. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2013 journal article

Selection of appropriate training and validation set chemicals for modelling dermal permeability by U-optimal design

SAR and QSAR in Environmental Research, 24(2), 135–156.

By: G. Xu n, J. Hughes-Oliver*, J. Brooks n, J. Yeatts n & R. Baynes n

author keywords: QSAR model; training set selection; Baynes' Rule; U-optimal design; principal component analysis (PCA); applicability domain (AD)
MeSH headings : Chemistry / methods; Inorganic Chemicals / chemistry; Inorganic Chemicals / pharmacokinetics; Models, Statistical; Organic Chemicals / chemistry; Organic Chemicals / pharmacokinetics; Permeability; Quantitative Structure-Activity Relationship; Skin / drug effects
TL;DR: This paper describes a comprehensive procedure to select training sets from a large candidate set of 4534 solutes, using the newly proposed ‘Baynes’ rule’, which is a modification of Lipinski's ‘rule of five’ to screen out solutes that were not qualified for the study. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref
Added: August 6, 2018

2011 journal article

Hot topic: Milk and plasma disposition of thymol following intramammary administration of a phytoceutical mastitis treatment

JOURNAL OF DAIRY SCIENCE, 94(4), 1738–1743.

By: C. McPhee n, K. Anderson n, J. Yeatts n, S. Mason*, B. Barlow n & R. Baynes n

author keywords: Phyto-Mast; organic production; thymol; mastitis treatment
MeSH headings : Angelica sinensis; Animals; Anti-Infective Agents, Local / analysis; Anti-Infective Agents, Local / blood; Anti-Infective Agents, Local / therapeutic use; Dairying / methods; Drug Administration Routes; Drug Residues / analysis; Female; Gaultheria; Glycyrrhiza uralensis; Goats; Mammary Glands, Animal / metabolism; Mastitis / drug therapy; Mastitis / metabolism; Mastitis / veterinary; Milk / chemistry; Phytotherapy / veterinary; Pilot Projects; Thymol / analysis; Thymol / blood; Thymol / therapeutic use; Thymus Plant
TL;DR: This study developed an assay to quantify thymol (one of the active ingredients in Phyto-Mast), a plant-based mastitis treatment used on organic dairy farms, in milk and plasma using gas chromatography and mass spectrometry (GC-MS). (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Surfactant Effects on Skin Absorption of Model Organic Chemicals: Implications for Dermal Risk Assessment Studies

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, 73(11), 725–737.

By: J. Riviere n, J. Brooks n, J. Yeatts n & E. Koivisto n

MeSH headings : Administration, Cutaneous; Alkanesulfonic Acids / pharmacology; Animals; Complex Mixtures / chemistry; Complex Mixtures / pharmacokinetics; Drug Interactions; Female; Membranes, Artificial; Organic Chemicals / pharmacokinetics; Risk Assessment; Skin / drug effects; Skin / metabolism; Skin Absorption / drug effects; Skin Absorption / physiology; Sodium Dodecyl Sulfate / pharmacology; Solubility; Surface-Active Agents / pharmacology; Surgical Flaps; Swine; Water / chemistry
TL;DR: The inert three-fiber MCF array predicted absorptive fluxes seen in the ex vivo IPPSF, suggesting lack of any biological effects of the surfactants on skin. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Elimination kinetics of tilmicosin following intramammary administration in lactating dairy cattle

Journal of the American Veterinary Medical Association, 234(2), 245–248.

By: G. Smith*, J. Davis*, R. Baynes*, J. Yeatts*, B. Barlow* & J. Riviere*

MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / analysis; Anti-Bacterial Agents / pharmacokinetics; Cattle; Chromatography, High Pressure Liquid / methods; Chromatography, High Pressure Liquid / veterinary; Drug Residues / analysis; Female; Infusions, Parenteral / veterinary; Lactation; Mammary Glands, Animal / metabolism; Mastitis, Bovine / drug therapy; Mastitis, Bovine / metabolism; Metabolic Clearance Rate; Milk / chemistry; Prospective Studies; Tylosin / administration & dosage; Tylosin / analogs & derivatives; Tylosin / analysis; Tylosin / pharmacokinetics
TL;DR: Findings indicated that tilmicosin should not be administered by the intramammary route in lactating dairy cows, and milk from all glands of any cows accidentally treated should be discarded for a minimum of 82 days following intramamsary administration. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2008 journal article

Application of linear solvation energy relationships to a custom-made polyaniline solid-phase microextraction fiber and three commercial fibers

JOURNAL OF CHROMATOGRAPHY A, 1188(2), 108–117.

By: J. Yeatts n, R. Baynes n, X. Xia n & J. Riviere n

author keywords: polyaniline; solid-phase microextraction; biocides; linear solvation energy relationships; metal core fiber; partition coefficients
MeSH headings : Acrylic Resins / chemistry; Aniline Compounds / chemistry; Dimethylpolysiloxanes / chemistry; Disinfectants / chemistry; Microscopy, Electron, Scanning; Polyethylene Glycols / chemistry; Reproducibility of Results; Solid Phase Microextraction / methods; Thermodynamics
TL;DR: The LSER study showed that the system properties having the greatest influence on log K were ease of cavity formation and hydrogen bond donating ability, and showed that all four fibers offer a unique environment for solute partitioning. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Predicting dermal permeability of biocides in commercial cutting fluids using a LSER approach

Toxicology Letters, 175(1-3), 34–43.

By: V. Vijay, J. Yeatts, J. Riviere & R. Baynes

Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

Analysis of diltiazem in Lipoderm (R) transdermal gel using reversed-phase high-performance liquid chromatography applied to homogenization and stability studies

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 38(1), 60–65.

By: J. Buur n, R. Baynes n, J. Yeatts n, G. Davidson n & T. DeFrancesco n

author keywords: diltiazem; reverse-phase liquid chromatography; transdermal gel; drug stability; compounded drug analysis
MeSH headings : Calcium Channel Blockers / analysis; Chromatography, High Pressure Liquid / methods; Diltiazem / analysis; Drug Stability; Gels; Pharmaceutical Preparations / chemistry; Reference Standards; Reproducibility of Results
TL;DR: A simple and novel method for the extraction and quantification of diltiazem hydrochloride was developed and applied to homogenization and stability studies and showed excellent linearity from 50 to 250 mg/ml in undiluted gel. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2005 journal article

Pre-treatment effects of trichloroethylene on the dermal absorption of the biocide, triazine

TOXICOLOGY LETTERS, 159(3), 252–260.

By: R. Baynes n, J. Yeatts n, J. Brooks n & J. Riviere n

author keywords: triazine; skin; TCE; cutting fluids
MeSH headings : Animals; Diffusion Chambers, Culture; Female; In Vitro Techniques; Metallurgy; Permeability; Skin / drug effects; Skin / metabolism; Skin Absorption / drug effects; Swine; Triazines / pharmacokinetics; Trichloroethylene / pharmacology
TL;DR: It is demonstrated that TCE pre-treatment can significantly alter the dermal permeability to triazine, and workers who are chronically exposed to this or similar cleansers may be at increased risk of absorbing related skin irritants. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Elimination kinetics of ceftiofur hydrochloride after intramammary administration in lactating dairy cows

Journal of the American Veterinary Medical Association, 224(11), 1827–1830.

By: G. Smith n, R. Gehring*, J. Riviere*, J. Yeatts* & R. Baynes*

MeSH headings : Animals; Anti-Infective Agents, Local / administration & dosage; Anti-Infective Agents, Local / analysis; Anti-Infective Agents, Local / pharmacokinetics; Cattle; Cephalosporins / administration & dosage; Cephalosporins / analysis; Cephalosporins / pharmacokinetics; Chromatography, High Pressure Liquid / veterinary; Drug Residues / analysis; Female; Lactation; Mammary Glands, Animal / metabolism; Mastitis, Bovine / drug therapy; Milk / chemistry; Prospective Studies; Reagent Kits, Diagnostic / veterinary
TL;DR: Ceftiofur administered by the intramammary route as an extra-label treatment for mastitis in dairy cows reaches concentrations in milk greater than the tolerance set by the FDA. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2003 journal article

Percutaneous absorption of topical N,N-diethyl-m-toluamide (DEET): Effects of exposure variables and coadministered toxicants

Journal of Toxicology and Environmental Health. Part A, 66(2), 133–151.

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2002 journal article

Analysis of N,N-diethyl-m-toluamide in porcine skin perfusates using solid-phase extraction disks and reversed-phase high-performance liquid chromatography

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 780(1), 45–52.

By: R. Baynes n, J. Yeatts n & J. Riviere n

author keywords: N,N-Diethyl-m-toluamide
MeSH headings : Animals; Chromatography, High Pressure Liquid / methods; DEET / analysis; Insect Repellents / analysis; Permeability; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Skin / chemistry; Swine
TL;DR: An improved method was developed for determining transdermal diffusion of low levels of DEET following application to an in vitro porcine skin flow-through diffusion cell system and it was determined that DEET permeability in porcines skin was 2.55 x 10(-5)+/-0.54 x 10-5 cm/h. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

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