Works (11)

Updated: March 9th, 2024 05:01

2024 article

Expanded library of novel 2,3-pyrrolidinedione analogues exhibit anti-biofilm activity

Nie, M., Valdes-Pena, M. A., Frohock, B. H., Smits, E., Daiker, J. C., Gilbertie, J. M., … Pierce, J. G. (2024, February 1). BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Vol. 99.

By: M. Nie n, M. Valdes-Pena n, B. Frohock n, E. Smits n, J. Daiker n, J. Gilbertie n, L. V. Schnabel n, J. Pierce n

author keywords: Natural products; Antibiotics; Antimicrobial resistance; Biofilms; 2 3-pyrrolidinedione
TL;DR: A new library of 2,3-pyrrolidinedione analogues is reported that expands on the previous report on the antimicrobial studies of this heterocyclic scaffold and displayed antibiofilm properties and represent intriguing scaffolds for further optimization and development. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: January 7, 2024

2023 journal article

Antimicrobial Properties of Equine Stromal Cells and Platelets and Future Directions


author keywords: Horse; Antimicrobial; Regenerative; Biologic; Therapies; Mesenchymal stromal cells; Platelets
TL;DR: Mechanisms by which biological therapies exert antimicrobial effects are discussed, as well as potential applications and challenges in clinical implementation in equine practice. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: November 27, 2023

2022 journal article

A Platelet-Rich Plasma-Derived Biologic Clears Staphylococcus aureus Biofilms While Mitigating Cartilage Degeneration and Joint Inflammation in a Clinically Relevant Large Animal Infectious Arthritis Model

Frontiers in Cellular and Infection Microbiology, 12.

By: J. Gilbertie n, T. Schaer*, J. Engiles*, G. Seiler n, B. Deddens n, A. Schubert n, M. Jacob n, D. Stefanovski* ...

author keywords: infectious arthritis; S; aureus; biofilm; antimicrobial; platelets; cartilage; synovium; synovial fluid
MeSH headings : Amikacin; Animals; Anti-Bacterial Agents / pharmacology; Anti-Bacterial Agents / therapeutic use; Arthritis, Infectious / drug therapy; Biofilms; Biological Products; Disease Models, Animal; Horses; Inflammation; Platelet-Rich Plasma; Staphylococcal Infections / drug therapy; Staphylococcal Infections / veterinary; Staphylococcus aureus
TL;DR: The results demonstrate the in vivo efficacy of AMK+BIO-PLY and represents a new approach to restore and potentiate antimicrobial activity against synovial fluid biofilms. (via Semantic Scholar)
Sources: Web Of Science, Crossref, ORCID
Added: June 20, 2022

2022 journal article

Effect of BIO-PLYTM, a Platelet-Rich Plasma Derived Biologic on PRRSV-2-Infected Macrophages

Viruses, 14(12), 2666.

By: A. Frias-De-Diego n, J. Gilbertie*, F. Scholle n, S. Dejarnette n & E. Crisci n

author keywords: antivirals; biologic; porcine macrophages; PRRSV
MeSH headings : Humans; Swine; Animals; Horses; Porcine respiratory and reproductive syndrome virus; Porcine Reproductive and Respiratory Syndrome / prevention & control; Macrophages; Biological Products
TL;DR: The results show that BIO-PLYTM significantly reduces the amount of PRRSV viral load determined by RT-qPCR and the number of infectious viral particles measured by TCID50 in infected porcine alveolar and parenchymal macrophages. (via Semantic Scholar)
Sources: Web Of Science, ORCID, Crossref
Added: November 29, 2022

2022 journal article

Interleukin-1 beta in tendon injury enhances reparative gene and protein expression in mesenchymal stem cells


By: D. Koch n, A. Berglund n, K. Messenger n, J. Gilbertie n, I. Ellis n & L. Schnabel n

author keywords: tendon; cytokine; ultrafiltration probe; mesenchymal stem cell; licensing
TL;DR: The defined temporal cytokine microenvironment in a surgically induced model of equine tendon injury and changes in MSC gene and protein expression following in vitro inflammatory licensing with cytokines of similar concentration as identified in vivo support the need to further study the benefit of MSCs administered within the inflamed tendon microenvironment or exogenously licensed with IL-1β in vitro prior to treatment. (via Semantic Scholar)
Source: Web Of Science
Added: December 12, 2022

2022 journal article

Potent Activity of Ertapenem Plus Cefazolin Within Staphylococcal Biofilms: A Contributing Factor in the Treatment of Methicillin-Susceptible Staphylococcus aureus Endocarditis


author keywords: cefazolin; ertapenem; endocarditis; Staphylococcus aureus
TL;DR: Ertapenem reduces CZ concentrations required to eradicate MSSA biofilms to those achievable in vivo by standard dosing, translating into shorter bacteremia duration in patients with MSSA endocarditis. (via Semantic Scholar)
Source: Web Of Science
Added: May 10, 2022

2021 journal article

Host fibrinogen drives antimicrobial function in Staphylococcus aureus peritonitis through bacterial-mediated prothrombin activation


By: J. Prasad*, O. Negron*, X. Du*, E. Mullins*, J. Palumbo*, J. Gilbertie n, M. Hook, S. Grover* ...

author keywords: fibrinogen; prothrombin; coagulase; host defense
MeSH headings : Animals; Anti-Bacterial Agents / metabolism; Anti-Infective Agents / metabolism; Blood Coagulation; Coagulase / metabolism; Female; Fibrin / metabolism; Fibrinogen / metabolism; Fibrinogen / pharmacology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Peritonitis / metabolism; Prothrombin / metabolism; Staphylococcal Infections / microbiology; Staphylococcus aureus / metabolism; Staphylococcus aureus / pathogenicity; Thromboplastin
TL;DR: It is established that the thrombin/fibrinogen axis is fundamental to host antimicrobial defense, offer a possible explanation for the clinical observation that coagulase-negative staphylococci are a highly prominent infectious agent in peritonitis, and suggest caution against anticoagulants in individuals susceptible to peritoneal infections. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: February 8, 2021

2021 journal article

The combination of mitogenic stimulation and DNA damage induces chondrocyte senescence


By: M. Copp n, M. Flanders n, R. Gagliardi n, J. Gilbertie n, G. Sessions*, S. Chubinskaya*, R. Loeser*, L. Schnabel n, B. Diekman n

author keywords: SA-beta-gal; DNA damage; Osteoarthritis; Aging; TGF- beta 1; bFGF
MeSH headings : Animals; Ankle Joint; Cartilage, Articular / cytology; Cartilage, Articular / drug effects; Cartilage, Articular / metabolism; Cellular Senescence / drug effects; Cellular Senescence / genetics; Chemokine CCL2 / drug effects; Chemokine CCL2 / genetics; Chondrocytes / drug effects; Chondrocytes / metabolism; Cyclin-Dependent Kinase Inhibitor p16 / drug effects; Cyclin-Dependent Kinase Inhibitor p16 / metabolism; DNA Damage / genetics; Fibroblast Growth Factor 2 / pharmacology; Gene Expression / drug effects; Histones / drug effects; Histones / metabolism; Horses; Humans; In Vitro Techniques; Inflammation / genetics; Insulin-Like Growth Factor Binding Protein 3 / drug effects; Insulin-Like Growth Factor Binding Protein 3 / genetics; Interleukin-6 / genetics; Matrix Metalloproteinase 13 / drug effects; Matrix Metalloproteinase 13 / genetics; Mitogens / pharmacology; Stifle; Transforming Growth Factor beta1 / pharmacology; beta-Galactosidase / drug effects; beta-Galactosidase / metabolism
TL;DR: Treatment of cartilage explants with mitogenic stimuli in the context of cellular damage reliably induces high levels of SA-β-gal activity and other senescence markers, which provides a physiologically relevant model system to investigate the mechanisms of senescences induction. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: March 29, 2021

2020 journal article

Comprehensive phenotypic and genotypic characterization and comparison of virulence, biofilm, and antimicrobial resistance in urinary Escherichia coli isolated from canines


By: J. Gilbertie n, G. Levent*, K. Norman*, J. Vinasco*, H. Scott* & M. Jacob n

author keywords: Biofilm; Urinary tract infections; Canine; Uropathogenic; Escherichia coli; Antimicrobial resistance
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Biofilms / drug effects; Dog Diseases / microbiology; Dogs; Drug Resistance, Bacterial; Escherichia coli Infections / microbiology; Escherichia coli Infections / veterinary; Genotype; Microbial Sensitivity Tests; Urinary Tract Infections / microbiology; Urinary Tract Infections / veterinary; Uropathogenic Escherichia coli / classification; Uropathogenic Escherichia coli / drug effects; Uropathogenic Escherichia coli / genetics; Virulence Factors / genetics
TL;DR: UPECs isolated from clinical cases of canine UTIs show a broad negative association between antimicrobial resistance and biofilm formation, and this observation is supported both by phenotypic and genotypic endpoints. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: November 9, 2020

2020 journal article

Platelet-rich plasma lysate displays antibiofilm properties and restores antimicrobial activity against synovial fluid biofilms in vitro


By: J. Gilbertie n, T. Schaer*, A. Schubert n, M. Jacob n, S. Menegatti n, R. Lavoie n, L. Schnabel n

author keywords: biofilms; equine model; infectious arthritis; platelet-rich plasma; Staphylococcus aureus
MeSH headings : Aminoglycosides / pharmacology; Animals; Anti-Bacterial Agents / pharmacology; Arthritis, Infectious / drug therapy; Biofilms / drug effects; Female; Horses; Male; Molecular Weight; Platelet-Rich Plasma; Synovial Fluid / microbiology
TL;DR: Overall, PRP‐L exhibited synergism with amikacin against aminoglycoside tolerant biofilm aggregates with greater activity against gram‐positive bacteria, which could lead to a decrease in morbidity and mortality associated with infectious arthritis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: January 27, 2020

2019 article

5-Benzylidene-4-Oxazolidinones Are Synergistic with Antibiotics for the Treatment of Staphylococcus aureus Biofilms


By: B. Frohock n, J. Gilbertie n, J. Daiker n, L. Schnabel n & J. Pierce n

MeSH headings : Acinetobacter baumannii / drug effects; Anti-Bacterial Agents / pharmacology; Benzylidene Compounds / pharmacology; Biofilms / drug effects; Drug Synergism; Methicillin-Resistant Staphylococcus aureus / drug effects; Microbial Sensitivity Tests; Oxazolidinones / pharmacology; Staphylococcus aureus / physiology; Structure-Activity Relationship
TL;DR: An expanded set of 5‐benzylidene‐4‐oxazolidinones is reported that is able to inhibit the formation of Staphylococcus aureus biofilms, disperse preformed biofilm, and are able to significantly reduce the bacterial load in a robust collagen‐matrix model of biofilm infection. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: January 13, 2020

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