Jessica Gilbertie

Works (14)

Updated: April 24th, 2025 08:37

2025 article

Canine urothelial cell model to study intracellular bacterial community development by uropathogenic Escherichia coli

Gilbertie, J. M., Sheahan, B. J., Vaden, S. L., & Jacob, M. E. (2025, January 9). PLoS ONE, Vol. 20.

By: J. Gilbertie n, B. Sheahan n , S. Vaden n  & M. Jacob n

MeSH headings : Dogs; Animals; Uropathogenic Escherichia coli / pathogenicity; Urothelium / microbiology; Urothelium / cytology; Urinary Tract Infections / microbiology; Urinary Tract Infections / drug therapy; Adhesins, Escherichia coli / metabolism; Adhesins, Escherichia coli / genetics; Escherichia coli Infections / microbiology; Escherichia coli Infections / veterinary; Escherichia coli Infections / drug therapy; Fimbriae Proteins / genetics; Fimbriae Proteins / metabolism; Dog Diseases / microbiology; Urinary Bladder / microbiology; Humans
topics (OpenAlex): Urinary Tract Infections Management; Bladder and Urothelial Cancer Treatments; Gut microbiota and health
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 12, 2025

2025 article

Equine neutrophils selectively release neutrophil extracellular traps in response to chemical and bacterial agonists

Sheahan, B. J., Schubert, A. G., Schubert, W., Sheats, M. K., Schnabel, L. V., & Gilbertie, J. M. (2025, February 24). Frontiers in Veterinary Science, Vol. 12.

By: B. Sheahan n , A. Schubert n, W. Schubert*, M. Sheats n , L. Schnabel n  & J. Gilbertie n

author keywords: equine; neutrophils; neutrophil extracellular traps; citrullinated histones; NADPH-oxidase pathway; autophagy
topics (OpenAlex): Neutrophil, Myeloperoxidase and Oxidative Mechanisms; Nitric Oxide and Endothelin Effects; Immune Response and Inflammation
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: March 17, 2025

2024 journal article

Expanded library of novel 2,3-pyrrolidinedione analogues exhibit anti-biofilm activity

Bioorganic & Medicinal Chemistry Letters, 99, 129609.

By: M. Nie n, M. Alejandro Valdes-Pena n, B. Frohock n, E. Smits n, J. Daiker n, J. Gilbertie n, L. Schnabel n , J. Pierce n 

author keywords: Natural products; Antibiotics; Antimicrobial resistance; Biofilms; 2 3-pyrrolidinedione
MeSH headings : Anti-Bacterial Agents / pharmacology; Staphylococcus aureus; Methicillin-Resistant Staphylococcus aureus; Methicillin Resistance; Biofilms; Microbial Sensitivity Tests
topics (OpenAlex): Antimicrobial Peptides and Activities; Chemical Synthesis and Analysis; Phenothiazines and Benzothiazines Synthesis and Activities
TL;DR: A new library of 2,3-pyrrolidinedione analogues is reported that expands on the previous report on the antimicrobial studies of this heterocyclic scaffold and displayed antibiofilm properties and represent intriguing scaffolds for further optimization and development. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: January 7, 2024

2024 journal article

Fighting fibrin with fibrin: Vancomycin delivery into coagulase‐mediated Staphylococcus aureus biofilms via fibrin‐based nanoparticle binding

Journal of Biomedical Materials Research Part A, 112(12), 2071–2085.

By: G. Scull n, A. Aligwekwe n, Y. Rey n, D. Koch n, K. Nellenbach n, A. Sheridan n, S. Pandit n, J. Sollinger n ...

author keywords: biofilm; dermal infection; fibrin; nanoparticle; Staphylococcus aureus; vancomycin
MeSH headings : Vancomycin / pharmacology; Vancomycin / administration & dosage; Biofilms / drug effects; Fibrin / chemistry; Staphylococcus aureus / drug effects; Coagulase / metabolism; Animals; Nanoparticles / chemistry; Anti-Bacterial Agents / pharmacology; Humans; Staphylococcal Infections / drug therapy; Mice
topics (OpenAlex): Bacterial biofilms and quorum sensing; Antimicrobial Resistance in Staphylococcus; Oral microbiology and periodontitis research
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: June 24, 2024

2023 journal article

Antimicrobial Properties of Equine Stromal Cells and Platelets and Future Directions

Veterinary Clinics of North America: Equine Practice, 39(3), 565–578.

By: L. Pezzanite *, L. Chow *, S. Dow *, L. Goodrich *, J. Gilbertie* & L. Schnabel n 

author keywords: Horse; Antimicrobial; Regenerative; Biologic; Therapies; Mesenchymal stromal cells; Platelets
MeSH headings : Horses; Animals; Horse Diseases / therapy; Mesenchymal Stem Cells; Blood Platelets; Anti-Bacterial Agents
topics (OpenAlex): Periodontal Regeneration and Treatments; Mesenchymal stem cell research; Wound Healing and Treatments
TL;DR: Mechanisms by which biological therapies exert antimicrobial effects are discussed, as well as potential applications and challenges in clinical implementation in equine practice. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: November 27, 2023

2022 journal article

A Platelet-Rich Plasma-Derived Biologic Clears Staphylococcus aureus Biofilms While Mitigating Cartilage Degeneration and Joint Inflammation in a Clinically Relevant Large Animal Infectious Arthritis Model

Frontiers in Cellular and Infection Microbiology, 12.

By: J. Gilbertie n, T. Schaer *, J. Engiles *, G. Seiler n, B. Deddens n, A. Schubert n, M. Jacob n, D. Stefanovski * ...

author keywords: infectious arthritis; S; aureus; biofilm; antimicrobial; platelets; cartilage; synovium; synovial fluid
MeSH headings : Amikacin; Animals; Anti-Bacterial Agents / pharmacology; Anti-Bacterial Agents / therapeutic use; Arthritis, Infectious / drug therapy; Biofilms; Biological Products; Disease Models, Animal; Horses; Inflammation; Platelet-Rich Plasma; Staphylococcal Infections / drug therapy; Staphylococcal Infections / veterinary; Staphylococcus aureus
topics (OpenAlex): Orthopedic Infections and Treatments; Periodontal Regeneration and Treatments; Rabies epidemiology and control
TL;DR: The results demonstrate the in vivo efficacy of AMK+BIO-PLY and represents a new approach to restore and potentiate antimicrobial activity against synovial fluid biofilms. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, NC State University Libraries
Added: June 20, 2022

2022 journal article

Effect of BIO-PLYTM, a Platelet-Rich Plasma Derived Biologic on PRRSV-2-Infected Macrophages

Viruses, 14(12), 2666.

By: A. Frias-De-Diego n , J. Gilbertie*, F. Scholle n , S. Dejarnette n & E. Crisci n 

author keywords: antivirals; biologic; porcine macrophages; PRRSV
MeSH headings : Humans; Swine; Animals; Horses; Porcine respiratory and reproductive syndrome virus; Porcine Reproductive and Respiratory Syndrome / prevention & control; Macrophages; Biological Products
topics (OpenAlex): Periodontal Regeneration and Treatments; Microbial infections and disease research; Genital Health and Disease
TL;DR: The results show that BIO-PLYTM significantly reduces the amount of PRRSV viral load determined by RT-qPCR and the number of infectious viral particles measured by TCID50 in infected porcine alveolar and parenchymal macrophages. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: November 29, 2022

2022 journal article

Interleukin-1β in tendon injury enhances reparative gene and protein expression in mesenchymal stem cells

Frontiers in Veterinary Science, 9.

By: D. Koch n, A. Berglund n, K. Messenger n, J. Gilbertie n, I. Ellis n & L. Schnabel n 

author keywords: tendon; cytokine; ultrafiltration probe; mesenchymal stem cell; licensing
topics (OpenAlex): Tendon Structure and Treatment; Wound Healing and Treatments; Diabetic Foot Ulcer Assessment and Management
TL;DR: The defined temporal cytokine microenvironment in a surgically induced model of equine tendon injury and changes in MSC gene and protein expression following in vitro inflammatory licensing with cytokines of similar concentration as identified in vivo support the need to further study the benefit of MSCs administered within the inflamed tendon microenvironment or exogenously licensed with IL-1β in vitro prior to treatment. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: December 12, 2022

2022 journal article

Potent Activity of Ertapenem Plus Cefazolin Within Staphylococcal Biofilms: A Contributing Factor in the Treatment of Methicillin-Susceptible Staphylococcus aureus Endocarditis

Open Forum Infectious Diseases, 9(5).

By: J. Gilbertie n, E. Ulloa *, J. Daiker n, K. Nguyen *, D. Smelter *, W. Rose *, M. Geriak *, L. Schnabel n , V. Nizet *, G. Sakoulas *

author keywords: cefazolin; ertapenem; endocarditis; Staphylococcus aureus
topics (OpenAlex): Infective Endocarditis Diagnosis and Management; Antimicrobial Resistance in Staphylococcus; Bacterial Identification and Susceptibility Testing
TL;DR: Ertapenem reduces CZ concentrations required to eradicate MSSA biofilms to those achievable in vivo by standard dosing, translating into shorter bacteremia duration in patients with MSSA endocarditis. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: May 10, 2022

2020 article

Comprehensive phenotypic and genotypic characterization and comparison of virulence, biofilm, and antimicrobial resistance in urinary Escherichia coli isolated from canines

Gilbertie, J. M., Levent, G., Norman, K. N., Vinasco, J., Scott, H. M., & Jacob, M. E. (2020, August 12). Veterinary Microbiology.

By: J. Gilbertie n, G. Levent *, K. Norman *, J. Vinasco*, H. Scott * & M. Jacob n

author keywords: Biofilm; Urinary tract infections; Canine; Uropathogenic; Escherichia coli; Antimicrobial resistance
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Biofilms / drug effects; Dog Diseases / microbiology; Dogs; Drug Resistance, Bacterial; Escherichia coli Infections / microbiology; Escherichia coli Infections / veterinary; Genotype; Microbial Sensitivity Tests; Urinary Tract Infections / microbiology; Urinary Tract Infections / veterinary; Uropathogenic Escherichia coli / classification; Uropathogenic Escherichia coli / drug effects; Uropathogenic Escherichia coli / genetics; Virulence Factors / genetics
topics (OpenAlex): Gut microbiota and health; Escherichia coli research studies; Urinary Tract Infections Management
TL;DR: UPECs isolated from clinical cases of canine UTIs show a broad negative association between antimicrobial resistance and biofilm formation, and this observation is supported both by phenotypic and genotypic endpoints. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: November 9, 2020

2020 article

Host fibrinogen drives antimicrobial function in Staphylococcus aureus peritonitis through bacterial-mediated prothrombin activation

Prasad, J. M., Negrón, O., Du, X., Mullins, E. S., Palumbo, J. S., Gilbertie, J. M., … Flick, M. J. (2020, December 23). Proceedings of the National Academy of Sciences.

By: J. Prasad *, O. Negrón *, X. Du *, E. Mullins *, J. Palumbo *, J. Gilbertie n, M. Höök, S. Grover * ...

author keywords: fibrinogen; prothrombin; coagulase; host defense
MeSH headings : Animals; Anti-Bacterial Agents / metabolism; Anti-Infective Agents / metabolism; Blood Coagulation; Coagulase / metabolism; Female; Fibrin / metabolism; Fibrinogen / metabolism; Fibrinogen / pharmacology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Peritonitis / metabolism; Prothrombin / metabolism; Staphylococcal Infections / microbiology; Staphylococcus aureus / metabolism; Staphylococcus aureus / pathogenicity; Thromboplastin
topics (OpenAlex): Antimicrobial Resistance in Staphylococcus; Streptococcal Infections and Treatments; Clostridium difficile and Clostridium perfringens research
TL;DR: It is established that the thrombin/fibrinogen axis is fundamental to host antimicrobial defense, offer a possible explanation for the clinical observation that coagulase-negative staphylococci are a highly prominent infectious agent in peritonitis, and suggest caution against anticoagulants in individuals susceptible to peritoneal infections. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: February 8, 2021

2020 article

Platelet‐rich plasma lysate displays antibiofilm properties and restores antimicrobial activity against synovial fluid biofilms in vitro

Gilbertie, J. M., Schaer, T. P., Schubert, A. G., Jacob, M. E., Menegatti, S., Lavoie, R. A., & Schnabel, L. V. (2020, January 10). Journal of Orthopaedic Research®, Vol. 38, pp. 1365–1374.

By: J. Gilbertie n, T. Schaer *, A. Schubert n, M. Jacob n, S. Menegatti n , R. Lavoie  n, L. Schnabel n 

author keywords: biofilms; equine model; infectious arthritis; platelet-rich plasma; Staphylococcus aureus
MeSH headings : Aminoglycosides / pharmacology; Animals; Anti-Bacterial Agents / pharmacology; Arthritis, Infectious / drug therapy; Biofilms / drug effects; Female; Horses; Male; Molecular Weight; Platelet-Rich Plasma; Synovial Fluid / microbiology
topics (OpenAlex): Periodontal Regeneration and Treatments; Orthopedic Infections and Treatments; Genital Health and Disease
TL;DR: Overall, PRP‐L exhibited synergism with amikacin against aminoglycoside tolerant biofilm aggregates with greater activity against gram‐positive bacteria, which could lead to a decrease in morbidity and mortality associated with infectious arthritis. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 27, 2020

2020 article

The combination of mitogenic stimulation and DNA damage induces chondrocyte senescence

Copp, M. E., Flanders, M. C., Gagliardi, R., Gilbertie, J. M., Sessions, G. A., Chubinskaya, S., … Diekman, B. O. (2020, November 20). Osteoarthritis and Cartilage, Vol. 29, pp. 402–412.

By: M. Copp n, M. Flanders  n, R. Gagliardi n, J. Gilbertie n, G. Sessions *, S. Chubinskaya*, R. Loeser *, L. Schnabel n , B. Diekman n

author keywords: SA-beta-gal; DNA damage; Osteoarthritis; Aging; TGF- beta 1; bFGF
MeSH headings : Animals; Ankle Joint; Cartilage, Articular / cytology; Cartilage, Articular / drug effects; Cartilage, Articular / metabolism; Cellular Senescence / drug effects; Cellular Senescence / genetics; Chemokine CCL2 / drug effects; Chemokine CCL2 / genetics; Chondrocytes / drug effects; Chondrocytes / metabolism; Cyclin-Dependent Kinase Inhibitor p16 / drug effects; Cyclin-Dependent Kinase Inhibitor p16 / metabolism; DNA Damage / genetics; Fibroblast Growth Factor 2 / pharmacology; Gene Expression / drug effects; Histones / drug effects; Histones / metabolism; Horses; Humans; In Vitro Techniques; Inflammation / genetics; Insulin-Like Growth Factor Binding Protein 3 / drug effects; Insulin-Like Growth Factor Binding Protein 3 / genetics; Interleukin-6 / genetics; Matrix Metalloproteinase 13 / drug effects; Matrix Metalloproteinase 13 / genetics; Mitogens / pharmacology; Stifle; Transforming Growth Factor beta1 / pharmacology; beta-Galactosidase / drug effects; beta-Galactosidase / metabolism
topics (OpenAlex): Telomeres, Telomerase, and Senescence; Mesenchymal stem cell research; RNA Interference and Gene Delivery
TL;DR: Treatment of cartilage explants with mitogenic stimuli in the context of cellular damage reliably induces high levels of SA-β-gal activity and other senescence markers, which provides a physiologically relevant model system to investigate the mechanisms of senescences induction. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 29, 2021

2019 article

5‐Benzylidene‐4‐Oxazolidinones Are Synergistic with Antibiotics for the Treatment of Staphylococcus aureus Biofilms

Frohock, B. H., Gilbertie, J. M., Daiker, J. C., Schnabel, L. V., & Pierce, J. G. (2019, November 5). ChemBioChem, Vol. 12, pp. 933–937.

By: B. Frohock n, J. Gilbertie n, J. Daiker n, L. Schnabel n  & J. Pierce n 

MeSH headings : Acinetobacter baumannii / drug effects; Anti-Bacterial Agents / pharmacology; Benzylidene Compounds / pharmacology; Biofilms / drug effects; Drug Synergism; Methicillin-Resistant Staphylococcus aureus / drug effects; Microbial Sensitivity Tests; Oxazolidinones / pharmacology; Staphylococcus aureus / physiology; Structure-Activity Relationship
topics (OpenAlex): Synthesis and Catalytic Reactions; Click Chemistry and Applications; Chemical Synthesis and Analysis
TL;DR: An expanded set of 5‐benzylidene‐4‐oxazolidinones is reported that is able to inhibit the formation of Staphylococcus aureus biofilms, disperse preformed biofilm, and are able to significantly reduce the bacterial load in a robust collagen‐matrix model of biofilm infection. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 13, 2020

Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.

Certain data included herein are derived from the Web of Science© and InCites© (2026) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.