Jonathan M Horowitz
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Works (17)
Updated: July 5th, 2023 16:04
2013 journal article
Neural development is dependent on the function of specificity protein 2 in cell cycle progression
DEVELOPMENT, 140(3), 552–561.
co-author countries:
Austria 🇦🇹 United States of America 🇺🇸
author keywords: Neurogenesis; Neural stem cells; Neural progenitors; Sp2; Cell cycle; M phase; Mouse
MeSH headings : Animals; Brain / cytology; Brain / embryology; Brain / metabolism; Cell Count; Cell Cycle; Cell Proliferation; Crosses, Genetic; Embryo Implantation; Embryo, Mammalian / cytology; Embryo, Mammalian / metabolism; Embryonic Stem Cells / cytology; Embryonic Stem Cells / metabolism; Eye Proteins / genetics; Eye Proteins / metabolism; Female; Genetic Markers; Homeodomain Proteins / genetics; Homeodomain Proteins / metabolism; Homologous Recombination; Intermediate Filament Proteins / genetics; Intermediate Filament Proteins / metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins / genetics; Nerve Tissue Proteins / metabolism; Nestin; Neural Stem Cells / cytology; Neural Stem Cells / metabolism; Neurogenesis; Neurons / cytology; Neurons / metabolism; PAX6 Transcription Factor; Paired Box Transcription Factors / genetics; Paired Box Transcription Factors / metabolism; Repressor Proteins / genetics; Repressor Proteins / metabolism; Sp2 Transcription Factor / genetics; Sp2 Transcription Factor / metabolism; Stem Cell Niche; Transplantation Chimera / embryology; Transplantation Chimera / metabolism
dev.biologists.org (publisher PDF)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Constitutive autotaxin transcription by Nmyc-amplified and non-amplified neuroblastoma cells is regulated by a novel AP-1 and SP-mediated mechanism and abrogated by curcumin
FEBS LETTERS, 586(20), 3681–3691.
co-author countries:
Italy 🇮🇹 Japan 🇯🇵 United States of America 🇺🇸
author keywords: Autotaxin; Transcription; Neuroblastoma; AP-1; SP; Internally initiated SP3; Curcumin
MeSH headings : Cell Line, Tumor; Curcumin / pharmacology; Cyclic AMP / genetics; Gene Deletion; Genes, Reporter / genetics; Humans; Neuroblastoma / pathology; Phosphoric Diester Hydrolases / deficiency; Phosphoric Diester Hydrolases / genetics; Proto-Oncogene Proteins c-myc / metabolism; Response Elements / drug effects; Response Elements / genetics; Sp Transcription Factors / metabolism; Transcription Factor AP-1 / metabolism; Transcription, Genetic / drug effects; Transcriptional Activation / drug effects
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Measuring the intra-individual variability of the plasma proteome in the chicken model of spontaneous ovarian adenocarcinoma
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 398(2), 737–749.
co-author countries:
United States of America 🇺🇸
Contributors: A. Hawkridge n, R. Wysocky n, J. Petitte n , K. Anderson n , P. Mozdziak n , O. Fletcher n, n, D. Muddiman n
author keywords: Genomics/proteomics; Mass spectrometry/ICP-MS; Biological samples; Bioanalytical methods; Clinical/biomedical analysis
MeSH headings : Adenocarcinoma / metabolism; Adenocarcinoma / pathology; Animals; Chickens; Female; Humans; Mass Spectrometry / methods; Ovarian Neoplasms / metabolism; Ovarian Neoplasms / pathology; Plasma / metabolism; Proteome / analysis; Proteome / metabolism; Proteomics / methods
Sources: Web Of Science, ORCID
Added: August 6, 2018
2010 article
Measuring the intra-individual variability of the plasma proteome in the chicken model of spontaneous ovarian adenocarcinoma (vol 398, pg 737, 2010)
Hawkridge, A. M., Wysocky, R. B., Petitte, J. N., Anderson, K. E., Mozdziak, P. E., Fletcher, O. J., … Muddiman, D. C. (2010, October). ANALYTICAL AND BIOANALYTICAL CHEMISTRY, Vol. 398, pp. 1835–1835.
co-author countries:
United States of America 🇺🇸
Contributors: A. Hawkridge n, R. Wysocky n, J. Petitte n , K. Anderson n , P. Mozdziak n , O. Fletcher n, n, D. Muddiman n
Sources: Web Of Science, ORCID
Added: August 6, 2018
2010 journal article
Overexpression of Transcription Factor Sp2 Inhibits Epidermal Differentiation and Increases Susceptibility to Wound- and Carcinogen-Induced Tumorigenesis
CANCER RESEARCH, 70(21), 8507–8516.
co-author countries:
United States of America 🇺🇸
MeSH headings : 9,10-Dimethyl-1,2-benzanthracene / toxicity; Animals; Blotting, Western; COS Cells; Carcinogens / toxicity; Carcinoma, Squamous Cell / etiology; Carcinoma, Squamous Cell / metabolism; Carcinoma, Squamous Cell / pathology; Cattle; Cell Differentiation; Chlorocebus aethiops; Disease Susceptibility; Epidermal Cells; Epidermis / drug effects; Epidermis / metabolism; Female; Humans; Immunoenzyme Techniques; Keratin-5 / genetics; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / metabolism; Male; Mice; Mice, Transgenic; Promoter Regions, Genetic; RNA, Messenger / genetics; Reverse Transcriptase Polymerase Chain Reaction; Skin Neoplasms / etiology; Skin Neoplasms / metabolism; Skin Neoplasms / pathology; Sp2 Transcription Factor / physiology; Wounds and Injuries
Sources: Web Of Science, ORCID
Added: August 6, 2018
2010 journal article
Transcription of mouse Sp2 yields alternatively spliced and sub-genomic mRNAs in a tissue- and cell-type-specific fashion
Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms, 1799(7), 520–531.
MeSH headings : Alternative Splicing; Animals; Brain / embryology; Brain / metabolism; Gene Expression Regulation; Gene Expression Regulation, Developmental; HeLa Cells; Humans; In Situ Hybridization; Mice; Mice, Transgenic; Models, Genetic; Promoter Regions, Genetic; Protein Binding; Protein Structure, Tertiary; Sp2 Transcription Factor / metabolism
Source: NC State University Libraries
Added: August 6, 2018
2009 journal article
Sp2 Is a Maternally Inherited Transcription Factor Required for Embryonic Development
Journal of Biological Chemistry, 285(6), 4153–4164.
co-author countries:
United States of America 🇺🇸
MeSH headings : Amino Acid Sequence; Animals; COS Cells; Chlorocebus aethiops; Chromosome Mapping; Embryo, Mammalian / embryology; Embryo, Mammalian / metabolism; Female; Gene Expression Regulation, Developmental; Green Fluorescent Proteins / genetics; Green Fluorescent Proteins / metabolism; Humans; In Situ Hybridization; Male; Mice; Microscopy, Fluorescence; Molecular Sequence Data; Phylogeny; Promoter Regions, Genetic / genetics; RNA, Messenger, Stored / genetics; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Sp2 Transcription Factor / classification; Sp2 Transcription Factor / genetics; Sp2 Transcription Factor / metabolism; Synteny; Transcription, Genetic; Zebrafish / embryology; Zebrafish / genetics; Zebrafish / growth & development; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2006 journal article
Early growth response gene-1 regulates hypoxia-induced expression of tissue factor in glioblastoma multiforme through hypoxia-inducible factor-1-independent mechanisms
CANCER RESEARCH, 66(14), 7067–7074.
co-author countries:
China 🇨🇳 United States of America 🇺🇸
MeSH headings : Cell Hypoxia / physiology; Cell Line, Tumor; Early Growth Response Protein 1 / biosynthesis; Early Growth Response Protein 1 / genetics; Glioblastoma / genetics; Glioblastoma / metabolism; Humans; Hypoxia-Inducible Factor 1 / biosynthesis; Hypoxia-Inducible Factor 1 / genetics; NF-kappa B / biosynthesis; NF-kappa B / genetics; Promoter Regions, Genetic; Proto-Oncogene Proteins c-jun / biosynthesis; Proto-Oncogene Proteins c-jun / genetics; Sp1 Transcription Factor / biosynthesis; Sp1 Transcription Factor / genetics; Thromboplastin / biosynthesis; Thromboplastin / genetics; Transcription Factor AP-1 / biosynthesis; Transcription Factor AP-1 / genetics; Transfection; Up-Regulation; Vascular Endothelial Growth Factor A / genetics
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Nkx3.1 binds and negatively regulates the transcriptional activity of Sp-family members in prostate-derived cells
BIOCHEMICAL JOURNAL, 393, 397–409.
co-author countries:
United States of America 🇺🇸
author keywords: histone deacetylase; Nkx3.1; prostate; prostate-specific antigen; Sp protein; transrepression
MeSH headings : Animals; Cell Line; Down-Regulation; Homeodomain Proteins / genetics; Homeodomain Proteins / metabolism; Humans; Male; Mice; Promoter Regions, Genetic; Prostate / cytology; Prostate-Specific Antigen / metabolism; Sp Transcription Factors / genetics; Sp Transcription Factors / metabolism; Transcription Factors / genetics; Transcription Factors / metabolism; Transcription, Genetic; Transcriptional Activation
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Sp2 localizes to subnuclear foci associated with the nuclear matrix
MOLECULAR BIOLOGY OF THE CELL, 17(4), 1711–1722.
co-author countries:
United States of America 🇺🇸
MeSH headings : Amino Acid Sequence; Animals; COS Cells; Chlorocebus aethiops; Humans; Interphase; Molecular Sequence Data; Nuclear Matrix / chemistry; Nuclear Matrix / metabolism; Protein Array Analysis; Protein Structure, Tertiary; Sequence Deletion; Sp Transcription Factors / analysis; Sp Transcription Factors / metabolism; Sp2 Transcription Factor / analysis; Sp2 Transcription Factor / genetics; Sp2 Transcription Factor / metabolism; Transfection; Zinc Fingers / genetics
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Sumoylation of internally initiated Sp3 isoforms regulates transcriptional repression via a Trichostatin A-insensitive mechanism
CELLULAR SIGNALLING, 17(2), 153–166.
co-author countries:
United States of America 🇺🇸
author keywords: sumoylation; trichostatin A; SP3; PML; transcriptional regulation; trans-activation; trans-repression
MeSH headings : Amino Acid Substitution; Animals; Blotting, Western; COS Cells; Cell Line; Cell Line, Tumor; Cell Nucleus / chemistry; Cell Nucleus / metabolism; Chlorocebus aethiops; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Enzyme Inhibitors / pharmacology; Ethylmaleimide / chemistry; Humans; Hydroxamic Acids / pharmacology; Immunohistochemistry; Lysine / metabolism; Neoplasm Proteins / genetics; Neoplasm Proteins / metabolism; Nuclear Proteins / genetics; Nuclear Proteins / metabolism; Promoter Regions, Genetic / genetics; Promyelocytic Leukemia Protein; Prostate-Specific Antigen / genetics; Protein Isoforms / genetics; Protein Isoforms / metabolism; SUMO-1 Protein / genetics; SUMO-1 Protein / metabolism; Sp1 Transcription Factor / chemistry; Sp1 Transcription Factor / metabolism; Sp3 Transcription Factor; Tetrahydrofolate Dehydrogenase / genetics; Transcription Factors / chemistry; Transcription Factors / genetics; Transcription Factors / metabolism; Transcriptional Activation / drug effects; Transfection; Tumor Suppressor Proteins; Two-Hybrid System Techniques; Ubiquitin-Conjugating Enzymes / metabolism
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Sp2 DNA binding activity and trans-activation are negatively regulated in mammalian cells
JOURNAL OF BIOLOGICAL CHEMISTRY, 279(14), 13911–13924.
co-author countries:
United States of America 🇺🇸
MeSH headings : Animals; Base Sequence; COS Cells; Consensus Sequence; Cricetinae; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Epithelial Cells / cytology; Epithelial Cells / physiology; Humans; Male; Mammals; Mice; Promoter Regions, Genetic / physiology; Prostate / cytology; Prostate-Specific Antigen / genetics; Protein Structure, Tertiary; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / metabolism; Sp1 Transcription Factor / chemistry; Sp1 Transcription Factor / genetics; Sp1 Transcription Factor / metabolism; Sp2 Transcription Factor; Sp3 Transcription Factor; Tetrahydrofolate Dehydrogenase / genetics; Transcription Factors / chemistry; Transcription Factors / genetics; Transcription Factors / metabolism; Transcription, Genetic / physiology
Source: Web Of Science
Added: August 6, 2018
2002 journal article
Sp3 represses gene expression via the titration of promoter-specific transcription factors
JOURNAL OF BIOLOGICAL CHEMISTRY, 277(12), 9780–9789.
co-author countries:
United States of America 🇺🇸
MeSH headings : Amino Acids / chemistry; Animals; Binding, Competitive; Cell Line; Cell Nucleus / metabolism; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Drosophila; Gene Expression; Genes, MDR / genetics; Humans; Insecta; Mutagenesis, Site-Directed; Mutation; Plasmids / metabolism; Polymerase Chain Reaction; Promoter Regions, Genetic; Protein Binding; Protein Biosynthesis; Protein Isoforms; Protein Structure, Tertiary; Proto-Oncogene Proteins p21(ras) / genetics; Sequence Analysis, DNA; Sp3 Transcription Factor; Tetrahydrofolate Dehydrogenase / genetics; Time Factors; Transcription Factors / genetics; Transcription Factors / metabolism; Transcription, Genetic; Transcriptional Activation; Transfection; Tumor Cells, Cultured
Source: Web Of Science
Added: August 6, 2018
2001 journal article
Molecular cloning and characterization of human nonsteroidal anti-inflammatory drug-activated gene promoter - Basal transcription is mediated by Sp1 and Sp3
JOURNAL OF BIOLOGICAL CHEMISTRY, 276(36), 33384–33392.
MeSH headings : Anti-Inflammatory Agents, Non-Steroidal / pharmacology; Base Sequence; Binding Sites; COUP Transcription Factor I; Cell Nucleus / metabolism; Chromatin / metabolism; Cloning, Molecular; Cytokines / genetics; Cytokines / metabolism; DNA-Binding Proteins / metabolism; Gene Deletion; Genes, Reporter; Glutathione Transferase / metabolism; Growth Differentiation Factor 15; Humans; Models, Genetic; Molecular Sequence Data; Mutation; Plasmids / metabolism; Precipitin Tests; Promoter Regions, Genetic; Protein Binding; Protein Isoforms; Protein Structure, Tertiary; Recombinant Fusion Proteins / metabolism; Recombinant Proteins / metabolism; Sequence Homology, Nucleic Acid; Sp1 Transcription Factor / metabolism; Sp3 Transcription Factor; Transcription Factors / metabolism; Transcription, Genetic; Transfection
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway
MOLECULAR AND CELLULAR BIOLOGY, 20(2), 672–683.
co-author countries:
Canada 🇨🇦 Israel 🇮🇱 United States of America 🇺🇸
MeSH headings : Animals; Binding Sites; Carrier Proteins; Cell Cycle Proteins; Cell Transformation, Neoplastic / pathology; Cyclin D1 / antagonists & inhibitors; Cyclin D1 / genetics; Cyclin D1 / metabolism; DNA-Binding Proteins / metabolism; E2F Transcription Factors; E2F1 Transcription Factor; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mammary Glands, Animal / metabolism; Mammary Glands, Animal / pathology; Mice; Mice, Nude; Mice, Transgenic; Mitogen-Activated Protein Kinases / antagonists & inhibitors; Mitogen-Activated Protein Kinases / metabolism; Monomeric GTP-Binding Proteins / genetics; Monomeric GTP-Binding Proteins / metabolism; Mutation / genetics; Promoter Regions, Genetic / genetics; Proto-Oncogene Mas; RNA, Antisense / genetics; RNA, Antisense / physiology; Receptor, ErbB-2 / antagonists & inhibitors; Receptor, ErbB-2 / genetics; Receptor, ErbB-2 / metabolism; Retinoblastoma-Binding Protein 1; Sp1 Transcription Factor / metabolism; Sp3 Transcription Factor; Transcription Factor DP1; Transcription Factors / metabolism; Transcriptional Activation; Tumor Cells, Cultured
Source: Web Of Science
Added: August 6, 2018
1998 journal article
Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7
MOLECULAR AND CELLULAR BIOLOGY, 18(5), 2748–2757.
co-author countries:
Germany 🇩🇪 United States of America 🇺🇸
MeSH headings : Amino Acid Sequence; Animals; Cell Cycle Proteins; DNA Replication; DNA, Complementary / genetics; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Humans; Male; Minichromosome Maintenance Complex Component 7; Molecular Sequence Data; Nuclear Proteins / genetics; Nuclear Proteins / metabolism; Ovum; Peptide Fragments / genetics; Peptide Fragments / metabolism; Phosphoproteins / metabolism; Protein Binding; Proteins; Recombinant Proteins / metabolism; Retinoblastoma Protein / genetics; Retinoblastoma Protein / metabolism; Retinoblastoma-Like Protein p107; Retinoblastoma-Like Protein p130; Spermatozoa; Xenopus; Xenopus Proteins
Source: Web Of Science
Added: August 6, 2018
1997 journal article
Subunit composition determines E2F DNA-binding site specificity
MOLECULAR AND CELLULAR BIOLOGY, 17(12), 6994–7007.
co-author countries:
United States of America 🇺🇸
MeSH headings : Animals; Baculoviridae / genetics; Base Sequence; Binding Sites / genetics; Carrier Proteins; Cell Cycle Proteins / genetics; Cell Cycle Proteins / metabolism; Cell Line; Consensus Sequence; Cricetinae; DNA / genetics; DNA / metabolism; DNA Primers / genetics; DNA-Binding Proteins; Dimerization; E2F Transcription Factors; E2F1 Transcription Factor; E2F4 Transcription Factor; E2F5 Transcription Factor; Humans; In Vitro Techniques; Polymerase Chain Reaction; Protein Conformation; Recombinant Proteins / chemistry; Recombinant Proteins / genetics; Recombinant Proteins / metabolism; Retinoblastoma Protein / genetics; Retinoblastoma Protein / metabolism; Retinoblastoma-Binding Protein 1; Transcription Factor DP1; Transcription Factors / chemistry; Transcription Factors / genetics; Transcription Factors / metabolism
Source: Web Of Science
Added: August 6, 2018
