Jonathan M Horowitz

Works (17)

Updated: April 4th, 2024 20:32

2013 article

Neural development is dependent on the function of specificity protein 2 in cell cycle progression

Liang, H., Xiao, G., Yin, H., Hippenmeyer, S., Horowitz, J. M., & Ghashghaei, H. T. (2013, January 4). Development.

By: H. Liang n, G. Xiao n, H. Yin n, S. Hippenmeyer *, J. Horowitz n & H. Ghashghaei n

author keywords: Neurogenesis; Neural stem cells; Neural progenitors; Sp2; Cell cycle; M phase; Mouse
MeSH headings : Animals; Brain / cytology; Brain / embryology; Brain / metabolism; Cell Count; Cell Cycle; Cell Proliferation; Crosses, Genetic; Embryo Implantation; Embryo, Mammalian / cytology; Embryo, Mammalian / metabolism; Embryonic Stem Cells / cytology; Embryonic Stem Cells / metabolism; Eye Proteins / genetics; Eye Proteins / metabolism; Female; Genetic Markers; Homeodomain Proteins / genetics; Homeodomain Proteins / metabolism; Homologous Recombination; Intermediate Filament Proteins / genetics; Intermediate Filament Proteins / metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins / genetics; Nerve Tissue Proteins / metabolism; Nestin; Neural Stem Cells / cytology; Neural Stem Cells / metabolism; Neurogenesis; Neurons / cytology; Neurons / metabolism; PAX6 Transcription Factor; Paired Box Transcription Factors / genetics; Paired Box Transcription Factors / metabolism; Repressor Proteins / genetics; Repressor Proteins / metabolism; Sp2 Transcription Factor / genetics; Sp2 Transcription Factor / metabolism; Stem Cell Niche; Transplantation Chimera / embryology; Transplantation Chimera / metabolism
topics (OpenAlex): Neurogenesis and neuroplasticity mechanisms; MicroRNA in disease regulation; RNA Research and Splicing
TL;DR: It is demonstrated that neural stem cells and intermediate neural progenitor cells (NPCs) employ a zinc-finger transcription factor specificity protein 2 (Sp2) as a cell cycle regulator in two temporally and spatially distinct progenitors domains. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2012 article

Constitutive autotaxin transcription by Nmyc‐amplified and non‐amplified neuroblastoma cells is regulated by a novel AP‐1 and SP‐mediated mechanism and abrogated by curcumin

Farina, A. R., Cappabianca, L., Ruggeri, P., Ianni, N. D., Ragone, M., Merolle, S., … Mackay, A. R. (2012, September 6). FEBS Letters.

By: A. Farina *, L. Cappabianca *, P. Ruggeri*, N. Ianni *, M. Ragone*, S. Merolle*, K. Sano*, M. Stracke* ...

author keywords: Autotaxin; Transcription; Neuroblastoma; AP-1; SP; Internally initiated SP3; Curcumin
MeSH headings : Cell Line, Tumor; Curcumin / pharmacology; Cyclic AMP / genetics; Gene Deletion; Genes, Reporter / genetics; Humans; Neuroblastoma / pathology; Phosphoric Diester Hydrolases / deficiency; Phosphoric Diester Hydrolases / genetics; Proto-Oncogene Proteins c-myc / metabolism; Response Elements / drug effects; Response Elements / genetics; Sp Transcription Factors / metabolism; Transcription Factor AP-1 / metabolism; Transcription, Genetic / drug effects; Transcriptional Activation / drug effects
topics (OpenAlex): Sphingolipid Metabolism and Signaling; Endoplasmic Reticulum Stress and Disease; Neuroblastoma Research and Treatments
TL;DR: A novel Atx transcriptional mechanism is characterised, utilised by both cell lines, that is restricted to the first 285 bp of the Atx promoter and involves AP‐1 and SP transcription factors, acting through a CRE/AP‐1‐like element at position −142 to −149 and a GAbox relative to the AtX translational start site. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2010 article

Erratum to: Measuring the intra-individual variability of the plasma proteome in the chicken model of spontaneous ovarian adenocarcinoma

Hawkridge, A. M., Wysocky, R. B., Petitte, J. N., Anderson, K. E., Mozdziak, P. E., Fletcher, O. J., … Muddiman, D. C. (2010, August 13). Analytical and Bioanalytical Chemistry, Vol. 398, pp. 1835–1835.

By: A. Hawkridge n, R. Wysocky n, J. Petitte n , K. Anderson n , P. Mozdziak n , O. Fletcher n, J. Horowitz n, D. Muddiman n 

Contributors: A. Hawkridge n, R. Wysocky n, J. Petitte n , K. Anderson n , P. Mozdziak n , O. Fletcher n, J. Horowitz n, D. Muddiman n 

topics (OpenAlex): Advanced Proteomics Techniques and Applications
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2. Zero Hunger (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2010 article

Measuring the intra-individual variability of the plasma proteome in the chicken model of spontaneous ovarian adenocarcinoma

Hawkridge, A. M., Wysocky, R. B., Petitte, J. N., Anderson, K. E., Mozdziak, P. E., Fletcher, O. J., … Muddiman, D. C. (2010, July 16). Analytical and Bioanalytical Chemistry, Vol. 398, pp. 737–749.

By: A. Hawkridge n, R. Wysocky n, J. Petitte n , K. Anderson n , P. Mozdziak n , O. Fletcher n, J. Horowitz n, D. Muddiman n 

Contributors: A. Hawkridge n, R. Wysocky n, J. Petitte n , K. Anderson n , P. Mozdziak n , O. Fletcher n, J. Horowitz n, D. Muddiman n 

author keywords: Genomics/proteomics; Mass spectrometry/ICP-MS; Biological samples; Bioanalytical methods; Clinical/biomedical analysis
MeSH headings : Adenocarcinoma / metabolism; Adenocarcinoma / pathology; Animals; Chickens; Female; Humans; Mass Spectrometry / methods; Ovarian Neoplasms / metabolism; Ovarian Neoplasms / pathology; Plasma / metabolism; Proteome / analysis; Proteome / metabolism; Proteomics / methods
topics (OpenAlex): Advanced Proteomics Techniques and Applications; Molecular Biology Techniques and Applications; Animal Virus Infections Studies
TL;DR: An experimental strategy for biomarker discovery is reported herein that combines the chicken model of EOC, longitudinal plasma sample collection with matched tissues, advanced mass spectrometry-based proteomics, and concepts derived from the index of individuality in an effort to identify diagnostic protein biomarkers. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2010 article

Overexpression of Transcription Factor Sp2 Inhibits Epidermal Differentiation and Increases Susceptibility to Wound- and Carcinogen-Induced Tumorigenesis

Kim, T.-H., Chiera, S. L., Linder, K. E., Trempus, C. S., Smart, R. C., & Horowitz, J. M. (2010, October 20). Cancer Research, Vol. 70, pp. 8507–8516.

By: T. Kim n, S. Chiera n, K. Linder n, C. Trempus n, R. Smart n  & J. Horowitz n

MeSH headings : 9,10-Dimethyl-1,2-benzanthracene / toxicity; Animals; Blotting, Western; COS Cells; Carcinogens / toxicity; Carcinoma, Squamous Cell / etiology; Carcinoma, Squamous Cell / metabolism; Carcinoma, Squamous Cell / pathology; Cattle; Cell Differentiation; Chlorocebus aethiops; Disease Susceptibility; Epidermal Cells; Epidermis / drug effects; Epidermis / metabolism; Female; Humans; Immunoenzyme Techniques; Keratin-5 / genetics; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / metabolism; Male; Mice; Mice, Transgenic; Promoter Regions, Genetic; RNA, Messenger / genetics; Reverse Transcriptase Polymerase Chain Reaction; Skin Neoplasms / etiology; Skin Neoplasms / metabolism; Skin Neoplasms / pathology; Sp2 Transcription Factor / physiology; Wounds and Injuries
topics (OpenAlex): Cancer-related gene regulation; Kruppel-like factors research; Genomics and Chromatin Dynamics
TL;DR: It is reported that Sp2 protein abundance in mice increases in concert with the progression of carcinogen-induced murine squamous cell carcinomas, and this results directly support the likelihood that Sp2 overexpression occurring in various human cancers has significant functional effect. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 article

Transcription of mouse Sp2 yields alternatively spliced and sub-genomic mRNAs in a tissue- and cell-type-specific fashion

Yin, H., Nichols, T. D., & Horowitz, J. M. (2010, March 30). Biochimica Et Biophysica Acta (BBA) - Gene Regulatory Mechanisms.

By: H. Yin  n, T. Nichols n & J. Horowitz n

MeSH headings : Alternative Splicing; Animals; Brain / embryology; Brain / metabolism; Gene Expression Regulation; Gene Expression Regulation, Developmental; HeLa Cells; Humans; In Situ Hybridization; Mice; Mice, Transgenic; Models, Genetic; Promoter Regions, Genetic; Protein Binding; Protein Structure, Tertiary; Sp2 Transcription Factor / metabolism
topics (OpenAlex): RNA Research and Splicing; Genomics and Chromatin Dynamics; RNA modifications and cancer
TL;DR: RNA in situ hybridization assays indicate that Sp2 is widely expressed during mouse embryogenesis, particularly in the embryonic brain, and robust Sp2 expression occurs in neurogenic regions of the post-natal and adult brain. (via Semantic Scholar)
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Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

Sp2 Is a Maternally Inherited Transcription Factor Required for Embryonic Development

Journal of Biological Chemistry, 285(6), 4153–4164.

By: J. Xie, H. Yin, T. Nichols, J. Yoder*  & J. Horowitz n

MeSH headings : Amino Acid Sequence; Animals; COS Cells; Chlorocebus aethiops; Chromosome Mapping; Embryo, Mammalian / embryology; Embryo, Mammalian / metabolism; Female; Gene Expression Regulation, Developmental; Green Fluorescent Proteins / genetics; Green Fluorescent Proteins / metabolism; Humans; In Situ Hybridization; Male; Mice; Microscopy, Fluorescence; Molecular Sequence Data; Phylogeny; Promoter Regions, Genetic / genetics; RNA, Messenger, Stored / genetics; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Sp2 Transcription Factor / classification; Sp2 Transcription Factor / genetics; Sp2 Transcription Factor / metabolism; Synteny; Transcription, Genetic; Zebrafish / embryology; Zebrafish / genetics; Zebrafish / growth & development; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism
topics (OpenAlex): Kruppel-like factors research; Cancer-related gene regulation; Epigenetics and DNA Methylation
TL;DR: The role(s) played by Sp2 in early metazoan development is addressed by cloned and characterized Sp2 from zebrafish, and the intron/exon organization and amino acid sequence of Sp2 is closely conserved with its mammalian orthologues. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018

2006 article

Early Growth Response Gene-1 Regulates Hypoxia-Induced Expression of Tissue Factor in Glioblastoma Multiforme through Hypoxia-Inducible Factor-1–Independent Mechanisms

Rong, Y., Hu, F., Huang, R. P., Mackman, N., Horowitz, J. M., Jensen, R. L., … Brat, D. J. (2006, July 15). Cancer Research.

By: Y. Rong, F. Hu *, R. Huang*, N. Mackman *, J. Horowitz n, R. Jensen *, D. Durden *, E. Meir *, D. Brat

MeSH headings : Cell Hypoxia / physiology; Cell Line, Tumor; Early Growth Response Protein 1 / biosynthesis; Early Growth Response Protein 1 / genetics; Glioblastoma / genetics; Glioblastoma / metabolism; Humans; Hypoxia-Inducible Factor 1 / biosynthesis; Hypoxia-Inducible Factor 1 / genetics; NF-kappa B / biosynthesis; NF-kappa B / genetics; Promoter Regions, Genetic; Proto-Oncogene Proteins c-jun / biosynthesis; Proto-Oncogene Proteins c-jun / genetics; Sp1 Transcription Factor / biosynthesis; Sp1 Transcription Factor / genetics; Thromboplastin / biosynthesis; Thromboplastin / genetics; Transcription Factor AP-1 / biosynthesis; Transcription Factor AP-1 / genetics; Transfection; Up-Regulation; Vascular Endothelial Growth Factor A / genetics
topics (OpenAlex): Cancer, Hypoxia, and Metabolism; interferon and immune responses; Cancer-related molecular mechanisms research
TL;DR: It is concluded that hypoxic up-regulation of tissue factor in glioblastoma multiforme cells depends largely on Egr-1 and is independent of HIF-1. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2006 article

Sp2 Localizes to Subnuclear Foci Associated with the Nuclear Matrix

Moorefield, K. S., Yin, H., Nichols, T. D., Cathcart, C., Simmons, S. O., & Horowitz, J. M. (2006, February 9). Molecular Biology of the Cell.

By: K. Moorefield n, H. Yin n, T. Nichols n, C. Cathcart *, S. Simmons n & J. Horowitz n

MeSH headings : Amino Acid Sequence; Animals; COS Cells; Chlorocebus aethiops; Humans; Interphase; Molecular Sequence Data; Nuclear Matrix / chemistry; Nuclear Matrix / metabolism; Protein Array Analysis; Protein Structure, Tertiary; Sequence Deletion; Sp Transcription Factors / analysis; Sp Transcription Factors / metabolism; Sp2 Transcription Factor / analysis; Sp2 Transcription Factor / genetics; Sp2 Transcription Factor / metabolism; Transfection; Zinc Fingers / genetics
topics (OpenAlex): Nuclear Structure and Function; RNA Research and Splicing; RNA modifications and cancer
TL;DR: It is concluded that Sp2 preferentially associates with the nuclear matrix and speculate that this subcellular localization plays an important role in the regulation of Sp2 function. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2005 article

Nkx3.1 binds and negatively regulates the transcriptional activity of Sp-family members in prostate-derived cells

Simmons, S. O., & Horowitz, J. M. (2005, December 12). Biochemical Journal.

By: S. Simmons  n & J. Horowitz n

author keywords: histone deacetylase; Nkx3.1; prostate; prostate-specific antigen; Sp protein; transrepression
MeSH headings : Animals; Cell Line; Down-Regulation; Homeodomain Proteins / genetics; Homeodomain Proteins / metabolism; Humans; Male; Mice; Promoter Regions, Genetic; Prostate / cytology; Prostate-Specific Antigen / metabolism; Sp Transcription Factors / genetics; Sp Transcription Factors / metabolism; Transcription Factors / genetics; Transcription Factors / metabolism; Transcription, Genetic; Transcriptional Activation
topics (OpenAlex): Tissue Engineering and Regenerative Medicine; Prostate Cancer Treatment and Research; Cancer-related gene regulation
TL;DR: It is reported that Nkx3.1 collaborates with Sp-family members in the regulation of PSA (prostate-specific antigen) in prostate-derived cells and negatively regulates Sp-mediated transcription via the tethering of histone deacetylases and/or by inhibiting the association of Sp proteins with co-activators. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2004 article

Sp2 DNA Binding Activity and trans-Activation Are Negatively Regulated in Mammalian Cells

Moorefield, K. S., Fry, S. J., & Horowitz, J. M. (2004, March 26). Journal of Biological Chemistry.

By: K. Moorefield n, S. Fry n & J. Horowitz n

MeSH headings : Animals; Base Sequence; COS Cells; Consensus Sequence; Cricetinae; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Epithelial Cells / cytology; Epithelial Cells / physiology; Humans; Male; Mammals; Mice; Promoter Regions, Genetic / physiology; Prostate / cytology; Prostate-Specific Antigen / genetics; Protein Structure, Tertiary; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / metabolism; Sp1 Transcription Factor / chemistry; Sp1 Transcription Factor / genetics; Sp1 Transcription Factor / metabolism; Sp2 Transcription Factor; Sp3 Transcription Factor; Tetrahydrofolate Dehydrogenase / genetics; Transcription Factors / chemistry; Transcription Factors / genetics; Transcription Factors / metabolism; Transcription, Genetic / physiology
topics (OpenAlex): RNA Research and Splicing; Cancer-related gene regulation; RNA modifications and cancer
TL;DR: Sp2 is functionally distinct relative to other Sp family members and suggest that Sp2 may play a unique role in cell physiology, using chimeric molecules prepared with portions of Sp1 and Sp2 and the human prostate-specific antigen promoter. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2004 article

Sumoylation of internally initiated Sp3 isoforms regulates transcriptional repression via a Trichostatin A-insensitive mechanism

Spengler, M. L., Kennett, S. B., Moorefield, K. S., Simmons, S. O., Brattain, M. G., & Horowitz, J. M. (2004, August 10). Cellular Signalling.

By: M. Spengler*, S. Kennett*, K. Moorefield n, S. Simmons  n, M. Brattain* & J. Horowitz n

author keywords: sumoylation; trichostatin A; SP3; PML; transcriptional regulation; trans-activation; trans-repression
MeSH headings : Amino Acid Substitution; Animals; Blotting, Western; COS Cells; Cell Line; Cell Line, Tumor; Cell Nucleus / chemistry; Cell Nucleus / metabolism; Chlorocebus aethiops; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Enzyme Inhibitors / pharmacology; Ethylmaleimide / chemistry; Humans; Hydroxamic Acids / pharmacology; Immunohistochemistry; Lysine / metabolism; Neoplasm Proteins / genetics; Neoplasm Proteins / metabolism; Nuclear Proteins / genetics; Nuclear Proteins / metabolism; Promoter Regions, Genetic / genetics; Promyelocytic Leukemia Protein; Prostate-Specific Antigen / genetics; Protein Isoforms / genetics; Protein Isoforms / metabolism; SUMO-1 Protein / genetics; SUMO-1 Protein / metabolism; Sp1 Transcription Factor / chemistry; Sp1 Transcription Factor / metabolism; Sp3 Transcription Factor; Tetrahydrofolate Dehydrogenase / genetics; Transcription Factors / chemistry; Transcription Factors / genetics; Transcription Factors / metabolism; Transcriptional Activation / drug effects; Transfection; Tumor Suppressor Proteins; Two-Hybrid System Techniques; Ubiquitin-Conjugating Enzymes / metabolism
topics (OpenAlex): Ubiquitin and proteasome pathways; Genomics and Chromatin Dynamics; RNA modifications and cancer
TL;DR: It is concluded that Sp3 isoforms are sumoylated in vivo and this post-translational modification plays an important role in the regulation of Sp3-mediated transcription. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2002 article

Sp3 Represses Gene Expression via the Titration of Promoter-specific Transcription Factors

Kennett, S. B., Moorefield, K. S., & Horowitz, J. M. (2002, March 1). Journal of Biological Chemistry.

By: S. Kennett n, K. Moorefield n & J. Horowitz n

MeSH headings : Amino Acids / chemistry; Animals; Binding, Competitive; Cell Line; Cell Nucleus / metabolism; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Drosophila; Gene Expression; Genes, MDR / genetics; Humans; Insecta; Mutagenesis, Site-Directed; Mutation; Plasmids / metabolism; Polymerase Chain Reaction; Promoter Regions, Genetic; Protein Binding; Protein Biosynthesis; Protein Isoforms; Protein Structure, Tertiary; Proto-Oncogene Proteins p21(ras) / genetics; Sequence Analysis, DNA; Sp3 Transcription Factor; Tetrahydrofolate Dehydrogenase / genetics; Time Factors; Transcription Factors / genetics; Transcription Factors / metabolism; Transcription, Genetic; Transcriptional Activation; Transfection; Tumor Cells, Cultured
topics (OpenAlex): Cancer-related gene regulation; RNA modifications and cancer; RNA Research and Splicing
TL;DR: Biochemical and functional analyses of mutated proteins indicate that functions encoded by the M2 carboxyl terminus, such as DNA binding activity and the capacity to form multimeric complexes, are not required or sufficient for transcriptional repression. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2001 article

Molecular Cloning and Characterization of Human Nonsteroidal Anti-inflammatory Drug-activated Gene Promoter

Baek, S. J., Horowitz, J. M., & Eling, T. E. (2001, September 1). Journal of Biological Chemistry.

By: S. Baek, J. Horowitz n & T. Eling*

MeSH headings : Anti-Inflammatory Agents, Non-Steroidal / pharmacology; Base Sequence; Binding Sites; COUP Transcription Factor I; Cell Nucleus / metabolism; Chromatin / metabolism; Cloning, Molecular; Cytokines / genetics; Cytokines / metabolism; DNA-Binding Proteins / metabolism; Gene Deletion; Genes, Reporter; Glutathione Transferase / metabolism; Growth Differentiation Factor 15; Humans; Models, Genetic; Molecular Sequence Data; Mutation; Plasmids / metabolism; Precipitin Tests; Promoter Regions, Genetic; Protein Binding; Protein Isoforms; Protein Structure, Tertiary; Recombinant Fusion Proteins / metabolism; Recombinant Proteins / metabolism; Sequence Homology, Nucleic Acid; Sp1 Transcription Factor / metabolism; Sp3 Transcription Factor; Transcription Factors / metabolism; Transcription, Genetic; Transfection
topics (OpenAlex): GDF15 and Related Biomarkers; Nuclear Receptors and Signaling; Macrophage Migration Inhibitory Factor
TL;DR: The results suggest that the level of expression of the NAG-1 gene will depend on the availability of Sp proteins and on co-factors such as chicken ovalbumin upstream promoter-transcription factor 1. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2000 article

Cyclin D1 Is Required for Transformation by Activated Neu and Is Induced through an E2F-Dependent Signaling Pathway

Lee, R. J., Albanese, C., Fu, M., D'Amico, M., Lin, B., Watanabe, G., … Pestell, R. G. (2000, January 15). Molecular and Cellular Biology.

By: R. Lee *, C. Albanese*, M. Fu*, M. D'Amico*, B. Lin n, G. Watanabe*, G. Haines*, P. Siegel * ...

MeSH headings : Animals; Binding Sites; Carrier Proteins; Cell Cycle Proteins; Cell Transformation, Neoplastic / pathology; Cyclin D1 / antagonists & inhibitors; Cyclin D1 / genetics; Cyclin D1 / metabolism; DNA-Binding Proteins / metabolism; E2F Transcription Factors; E2F1 Transcription Factor; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mammary Glands, Animal / metabolism; Mammary Glands, Animal / pathology; Mice; Mice, Nude; Mice, Transgenic; Mitogen-Activated Protein Kinases / antagonists & inhibitors; Mitogen-Activated Protein Kinases / metabolism; Monomeric GTP-Binding Proteins / genetics; Monomeric GTP-Binding Proteins / metabolism; Mutation / genetics; Promoter Regions, Genetic / genetics; Proto-Oncogene Mas; RNA, Antisense / genetics; RNA, Antisense / physiology; Receptor, ErbB-2 / antagonists & inhibitors; Receptor, ErbB-2 / genetics; Receptor, ErbB-2 / metabolism; Retinoblastoma-Binding Protein 1; Sp1 Transcription Factor / metabolism; Sp3 Transcription Factor; Transcription Factor DP1; Transcription Factors / metabolism; Transcriptional Activation; Tumor Cells, Cultured
topics (OpenAlex): Cancer-related Molecular Pathways; Cell death mechanisms and regulation; Ubiquitin and proteasome pathways
TL;DR: It is demonstrated that E2F-1 mediates a Neu-signaling cascade tocyclin D1 and identify cyclin D 1 as a critical downstream target of neu-induced transformation. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1998 article

Negative Regulation of DNA Replication by the Retinoblastoma Protein Is Mediated by Its Association with MCM7

Sterner, J. M., Dew-Knight, S., Musahl, C., Kornbluth, S., & Horowitz, J. M. (1998, May 1). Molecular and Cellular Biology.

By: J. Sterner, S. Dew-Knight, C. Musahl*, S. Kornbluth* & J. Horowitz*

MeSH headings : Amino Acid Sequence; Animals; Cell Cycle Proteins; DNA Replication; DNA, Complementary / genetics; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Humans; Male; Minichromosome Maintenance Complex Component 7; Molecular Sequence Data; Nuclear Proteins / genetics; Nuclear Proteins / metabolism; Ovum; Peptide Fragments / genetics; Peptide Fragments / metabolism; Phosphoproteins / metabolism; Protein Binding; Proteins; Recombinant Proteins / metabolism; Retinoblastoma Protein / genetics; Retinoblastoma Protein / metabolism; Retinoblastoma-Like Protein p107; Retinoblastoma-Like Protein p130; Spermatozoa; Xenopus; Xenopus Proteins
topics (OpenAlex): Cancer-related Molecular Pathways; Epigenetics and DNA Methylation; DNA Repair Mechanisms
TL;DR: These data provide the first evidence that Rb and Rb-related proteins can directly regulate DNA replication and that components of licensing factor are targets of the products of tumor suppressor genes. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1997 article

Subunit Composition Determines E2F DNA-Binding Site Specificity

Tao, Y., Kassatly, R. F., Cress, W. D., & Horowitz, J. M. (1997, December 1). Molecular and Cellular Biology.

By: Y. Tao *, R. Kassatly*, W. Cress * & J. Horowitz*

MeSH headings : Animals; Baculoviridae / genetics; Base Sequence; Binding Sites / genetics; Carrier Proteins; Cell Cycle Proteins / genetics; Cell Cycle Proteins / metabolism; Cell Line; Consensus Sequence; Cricetinae; DNA / genetics; DNA / metabolism; DNA Primers / genetics; DNA-Binding Proteins; Dimerization; E2F Transcription Factors; E2F1 Transcription Factor; E2F4 Transcription Factor; E2F5 Transcription Factor; Humans; In Vitro Techniques; Polymerase Chain Reaction; Protein Conformation; Recombinant Proteins / chemistry; Recombinant Proteins / genetics; Recombinant Proteins / metabolism; Retinoblastoma Protein / genetics; Retinoblastoma Protein / metabolism; Retinoblastoma-Binding Protein 1; Transcription Factor DP1; Transcription Factors / chemistry; Transcription Factors / genetics; Transcription Factors / metabolism
topics (OpenAlex): Cancer-related Molecular Pathways; Virus-based gene therapy research; Ocular Oncology and Treatments
TL;DR: Using recombinant E2F, DP, and Rb proteins prepared in baculovirus-infected cells and a repetitive immunoprecipitation-PCR procedure (CASTing), consensus DNA-binding sites are identified and indicate that the specific sequence of an E2f site may determine its role in transcriptional regulation and suggest that Rb/E2F complexes may regulate subsets of E1F-dependent cellular genes. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

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