Jerry M Law

Works (70)

Updated: April 3rd, 2024 22:22

2022 article

Cutaneous epitheliotropic lymphosarcoma in a captive white catfish (Ameiurus catus Linnaeus)

Heniff, A. C., Chen, L. R., Christiansen, E. F., Harms, C. A., Law, J. M., Legner, C., & Linder, K. E. (2022, April 27). JOURNAL OF FISH DISEASES, Vol. 4.

By: A. Heniff n, L. Chen n, E. Christiansen n, C. Harms n , J. Law n, C. Legner*, K. Linder n

author keywords: Ameiurus catus; cutaneous epitheliotropic lymphosarcoma; neoplasia; white catfish
MeSH headings : Animals; Epidermis / pathology; Fish Diseases; Ictaluridae; Lymphoma, Non-Hodgkin; Mammals; Skin Neoplasms / pathology; Skin Neoplasms / veterinary
TL;DR: This is the first reported case of cutaneous epitheliotropic lymphosarcoma in an ictalurid and one of the few published cases of this condition in any fish species. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 28, 2022

2021 article

Non-cardiogenic pulmonary oedema and multisystemic haemorrhage secondary to an accidental intravenous injection of melarsomine in a dog

Wolf, J., Law, J. M., & Lynch, A. (2021, September 29). VETERINARY RECORD CASE REPORTS, Vol. 9.

By: J. Wolf n, J. Law n & A. Lynch n 

author keywords: canine; dirofilariasis treatment; drug error
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 12, 2021

2019 journal article

Histological evaluation of five suture materials in the telson ligament of the American horseshoe crab (Limulus polyphemus)

PEERJ, 7.

By: A. Krasner, A. Hancock-Ronemus*, L. Christian*, E. Griffith n, G. Lewbart n  & J. Law n

author keywords: Limulus; Suture reaction; Telson ligament; Eugenol; Histopathology
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 19, 2019

2018 journal article

EVALUATION OF THE OPHTHALMIC DISEASE AND HISTOPATHOLOGIC EFFECTS DUE TO THE OCULAR TREMATODE PHILOPHTHALMUS ZALOPHI ON JUVENILE GALAPAGOS SEA LIONS (ZALOPHUS WOLLEBAEKI)

JOURNAL OF ZOO AND WILDLIFE MEDICINE, 49(3), 581–590.

By: B. Phillips, D. Paez-Rosas, J. Flowers*, J. Cullen*, J. Law*, C. Colitz, D. Deresienski*, K. Lohmann, G. Lewbart* 

author keywords: Conjunctival biopsy; eye trematode; Galapagos sea lion; Philophthalmus zalophi; Zalophus wollebaeki
MeSH headings : Aging; Animals; Ecuador / epidemiology; Eye Diseases / epidemiology; Eye Diseases / parasitology; Eye Diseases / veterinary; Sea Lions / parasitology; Trematoda / classification; Trematode Infections / epidemiology; Trematode Infections / parasitology; Trematode Infections / veterinary
TL;DR: The histopathologic changes and gross lesions were likely due to the parasite's attachment to the conjunctiva, and further research is warranted to detail the life cycle of this parasite, transmission to sea lions, and potential treatment protocols. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 21, 2019

2018 journal article

Lymphocyte Subsets in the Adrenal Glands of Dogs With Primary Hypoadrenocorticism

VETERINARY PATHOLOGY, 55(1), 177–181.

By: S. Friedenberg n, D. Brown, K. Meurs n  & J. Law n

author keywords: Addison's disease; hypoadrenocorticism; endocrine diseases; adrenal gland; immunophenotype; lymphocyte subsets; dogs
MeSH headings : Addison Disease / pathology; Addison Disease / veterinary; Adrenal Glands / pathology; Animals; CD4 Lymphocyte Count / veterinary; Dog Diseases / immunology; Dog Diseases / pathology; Dogs; Female; In Situ Hybridization / veterinary; Lymphocyte Subsets / pathology; Male
TL;DR: It is shown that the lymphocytes are primarily CD4+ rather than CD8+. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2018 journal article

Relation of contaminants to fish intersex in riverine sport fishes

Science of The Total Environment, 643, 73–89.

By: C. Grieshaber n, T. Penland n, T. Kwak n , W. Cope n , R. Heise*, J. Law n, D. Shea n , D. Aday n ...

Contributors: C. Grieshaber n, T. Penland n, T. Kwak n , W. Cope n , R. Heise*, J. Law n, D. Shea n , D. Aday n, J. Rice n, S. Kullman n 

author keywords: Endocrine active compounds; Endocrine disruption; Bass; Polycyclic aromatic hydrocarbons; Ethinylestradiol; Mercury
MeSH headings : Animals; Disorders of Sex Development / epidemiology; Disorders of Sex Development / veterinary; Environmental Monitoring; Female; Fish Diseases / epidemiology; Fishes / physiology; Male; North Carolina; Rivers / chemistry; South Carolina; Sports; Water Pollutants, Chemical / analysis; Water Pollution, Chemical / statistics & numerical data
TL;DR: Polycyclic aromatic hydrocarbons, ethinylestradiol, and heavy metals were the most prevalent contaminants that exceeded effect levels for the protection of aquatic organisms and principal component analysis identified waterborne PAHs as the most correlated environmental contaminant with intersex occurrence and severity in black bass and sunfish. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, Web Of Science, ORCID, NC State University Libraries
Added: October 16, 2018

2017 journal article

Disruption of Trim9 function abrogates macrophage motility in vivo

Journal of Leukocyte Biology, 102(6), 1371–1380.

By: D. Tokarz n, A. Heffelfinger n, D. Jima n, J. Gerlach n, R. Shah n, I. Rodriguez-Nunez  n, A. Kortum n, A. Fletcher  n ...

author keywords: chemotaxis; zebrafish; leukocyte; ubiquitin
MeSH headings : Animals; Cell Movement / genetics; Cell Shape; Chemotaxis; Humans; Macrophages / cytology; Macrophages / metabolism; Nerve Tissue Proteins / genetics; Nerve Tissue Proteins / metabolism; RNA, Messenger / genetics; RNA, Messenger / metabolism; Tripartite Motif Proteins / genetics; Tripartite Motif Proteins / metabolism; U937 Cells; Ubiquitin-Protein Ligases / genetics; Ubiquitin-Protein Ligases / metabolism; Zebrafish / genetics; Zebrafish / immunology; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism
TL;DR: It is demonstrated that Trim9 mediates cellular movement and migration in Mϕs as well as neurons, and is implicated in axonal migration, and found that M ϕ chemotaxis and cellular architecture are subsequently impaired in vivo. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2017 journal article

Windows of Susceptibility and Consequences of Early Life Exposures to 17β–estradiol on Medaka (Oryzias latipes) Reproductive Success

Environmental Science & Technology, 51(9), 5296–5305.

By: C. Lee Pow n, K. Tilahun  n, K. Creech n, J. Law n, W. Cope  n, T. Kwak n , J. Rice  n, D. Aday n, S. Kullman n 

MeSH headings : Animals; Estradiol / pharmacology; Gonads / drug effects; Oryzias; Reproduction / drug effects; Sex Differentiation / drug effects
TL;DR: Insight is provided into factors (window of exposure, exposure concentration and duration of exposure period) contributing to reproductive disruption in fish and differential effects among four critical stages of development are documents. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

Endocrine active contaminants in aquatic systems and intersex in common sport fishes

Environmental Toxicology and Chemistry, 36(4), 959–968.

By: C. Lee Pow n, J. Law n, T. Kwak  n, W. Cope  n, J. Rice  n, S. Kullman n , D. Aday n

author keywords: Intersex; Estrogens; Endocrine disruption; Black bass; Sunfish
MeSH headings : Animals; Bass / growth & development; Bass / metabolism; Disorders of Sex Development / chemically induced; Endocrine Disruptors / analysis; Endocrine Disruptors / toxicity; Endocrine System / drug effects; Environmental Monitoring; Female; Male; North Carolina; Oocytes / drug effects; Oocytes / growth & development; Rivers / chemistry; Seasons; Species Specificity; Sports; Testis / drug effects; Testis / growth & development; Water Pollutants, Chemical / analysis; Water Pollutants, Chemical / toxicity
TL;DR: The authors’ results associate genus‐specific prevalence of intersex with specific EAC classes in common sport fishes having biological, ecological, and conservation implications. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Crossref, Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Exuberant granulation tissue response associated with Neobenedenia sp. (Monogenea: Capsalidae) infestation in two cobia, Rachycentron canadum (Linnaeus)

Journal of Fish Diseases, 39(3), 277–283.

By: J. Hurley-Sanders n, C. Harms n , E. Christiansen n, E. Clarke n & J. Law n

author keywords: granulation tissue; Neobenedenia; Rachycentron canadum
MeSH headings : Animals; Animals, Zoo / parasitology; Fish Diseases / parasitology; Gills / parasitology; Granulation Tissue / parasitology; Perciformes / parasitology; Trematoda / physiology; Trematode Infections / parasitology; Trematode Infections / veterinary
TL;DR: An unusual pathological presentation of exuberant granulation tissue of the gills, suspected to be related to Neobenedenia infestation in two cobia housed together at a North Carolina aquarium is described. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2015 journal article

Key metabolites in tissue extracts ofElliptio complanataidentified using1H nuclear magnetic resonance spectroscopy

Conservation Physiology, 3(1), cov023.

By: J. Hurley-Sanders n, J. Levine n , S. Nelson n , J. Law n, W. Showers n & M. Stoskopf n

author keywords: Freshwater mussels; metabolites; nuclear magnetic resonance spectroscopy
TL;DR: Preliminary studies provide evidence for potential use of digestive gland and mantle tissue for studying physiological impacts of location, sex and reproductive condition on Elliptio complanata. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (Web of Science; OpenAlex)
15. Life on Land (Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2015 journal article

Laboratory Evaluation of Safety and Efficacy for Melafix (Melaleuca cajuputi Extract)

Journal of Exotic Pet Medicine, 24(2), 188–192.

By: R. Shivappa, L. Christian*, E. Noga, J. Law n & G. Lewbart n 

author keywords: Melafix; aquarium; water quality; goldfish; clownfish; MIC
TL;DR: The use of Melafix on goldfish and clownfish appears to be safe as no adverse effects were noted during the experimental period, and suggests that anecdotal benefits ofMelafix are not owing to antibacterial activity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Crossref, Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Nonlesions, misdiagnoses, missed diagnoses, and other interpretive challenges in fish histopathology studies: A guide for investigators, authors, reviewers, and readers

Toxicologic Pathology, 43(3), 297–325.

By: J. Wolf, W. Baumgartner, V. Blazer, A. Camus, J. Engelhardt, J. Fournie, S. Frasca, D. Groman ...

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Sources of endocrine-disrupting compounds in North Carolina waterways: A geographic information systems approach

Environmental Toxicology and Chemistry, 34(2), 437–445.

By: D. Sackett n, C. Pow n, M. Rubino n , D. Aday n, W. Cope  n, S. Kullman n , J. Rice  n, T. Kwak n , M. Law n

author keywords: Ecotoxicology; Endocrine disrupting compound; Estrogenicity; Geographic information system prediction; Surface water
MeSH headings : Endocrine Disruptors / analysis; Estradiol / analysis; Estrogens / analysis; Geographic Information Systems; Geography; Least-Squares Analysis; Models, Theoretical; North Carolina; Water Pollutants, Chemical / analysis
TL;DR: The results suggested that water 17β-estradiol was reflective of GIS predictions, confirming the relevance of landscape-level influences on water quality and validating the GIS approach to characterize such relationships. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (Web of Science; OpenAlex)
Sources: Crossref, Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2014 journal article

Nonlesions, Misdiagnoses, Missed Diagnoses, and Other Interpretive Challenges in Fish Histopathology Studies

Toxicologic Pathology, 43(3), 297–325.

By: J. Wolf *, W. Baumgartner*, V. Blazer *, A. Camus *, J. Engelhardt*, J. Fournie*, S. Frasca*, D. Groman* ...

author keywords: artifacts; diagnostic accuracy; fish histopathology; nonlesions; tissue fixation; misdiagnosis
MeSH headings : Animals; Diagnostic Errors; Fish Diseases / diagnosis; Fish Diseases / pathology; Fishes; Gills / pathology; Kidney / pathology; Liver / pathology; Reference Standards; Tissue Fixation
TL;DR: A number of specific morphologic findings in commonly examined fish tissues (e.g., gills, liver, kidney, and gonads) that are frequently either misdiagnosed or underdiagnosed are illustrated to address related issues involving the interpretation of histopathologic data. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: Crossref
Added: July 27, 2019

2014 journal article

Operative factors associated with short-term outcome in horses with large colon volvulus: 47 cases from 2006 to 2013

Equine Veterinary Journal, 47(3), 279–284.

By: L. Gonzalez n , C. Fogle n , W. Baker, F. Hughes*, J. Law n, A. Motsinger-Reif n, A. Blikslager n 

Contributors: L. Gonzalez n , C. Fogle n , W. Baker, F. Hughes*, J. Law n, A. Motsinger-Reif n, A. Blikslager n 

author keywords: horse; large colon volvulus; strangulation; pelvic flexure; surgery
MeSH headings : Animals; Biopsy; Colon / pathology; Hemorrhage / pathology; Hemorrhage / veterinary; Horse Diseases / surgery; Horses; Intestinal Volvulus / pathology; Intestinal Volvulus / surgery; Intestinal Volvulus / veterinary; Logistic Models; Retrospective Studies
TL;DR: Histomorphometric measurements of interstitium-to-crypt ratio and degree of haemorrhage predict short-term outcome in cases of large colon volvulus. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2014 journal article

The Effect of Tramadol and Indomethacin Coadministration on Gastric Barrier Function in Dogs

Journal of Veterinary Internal Medicine, 28(3), 793–798.

By: T. Hill *, B. Lascelles  n, J. M. Law & A. Blikslager n 

Contributors: T. Hill *, B. Lascelles  n, J. Law n & A. Blikslager n 

author keywords: NSAID; tramadol; ulcer
MeSH headings : Analgesics, Opioid / administration & dosage; Analgesics, Opioid / pharmacology; Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / pharmacology; Cyclooxygenase 1 / metabolism; Cyclooxygenase 2 / metabolism; Dinoprostone / analysis; Dogs; Drug Therapy, Combination; Gastric Mucosa / chemistry; Gastric Mucosa / drug effects; Gastric Mucosa / physiology; Indomethacin / administration & dosage; Indomethacin / pharmacology; Thromboxane B2 / analysis; Tramadol / administration & dosage; Tramadol / pharmacology
TL;DR: The results suggest that if there is an adverse interaction of the 2 drugs in vivo, it is unlikely to be via prostanoid inhibition, and could be via nonselective cyclooxygenase inhibition. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2013 journal article

Assessment of geographical variation in the respiratory toxicity of desert dust particles

INHALATION TOXICOLOGY, 25(7), 405–416.

By: K. Taylor n, M. Foster n, J. Law n, J. Centeno*, E. Fornero*, M. Henderson n, S. Trager n, M. Stockelman*, D. Dorman n

author keywords: Cytotoxicity; dust inhalation; in vitro; in vivo; particle toxicity; pulmonary toxicity; rat
MeSH headings : Administration, Inhalation; Afghanistan; Animals; Arsenic / analysis; Arsenic / toxicity; Bronchoalveolar Lavage Fluid / chemistry; Bronchoalveolar Lavage Fluid / cytology; Cell Count; Cell Line; Cell Survival / drug effects; Cytokines / metabolism; Dust / analysis; Endotoxins / analysis; Endotoxins / toxicity; Geography; Iraq; L-Lactate Dehydrogenase / metabolism; Lung / drug effects; Lung / metabolism; Lung / pathology; Male; Metals / analysis; Metals / toxicity; Rats; Silicon Dioxide / analysis; Silicon Dioxide / toxicity; United States
TL;DR: The in vitro cytotoxicity assay results were partially predictive of in vivo responses and could be used to prioritize future particle inhalation studies or guide epidemiological study design. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2013 article

Environmental Pathobiology and Global Opportunities

Schmidt, S. P., Jokinen, M. P., Law, J. M., Pandiri, A. R., Weddle, D. L., Wolf, J. C., & Sills, R. C. (2013, September). VETERINARY PATHOLOGY, Vol. 50, pp. 733–734.

By: S. Schmidt*, M. Jokinen*, J. Law n, A. Pandiri *, D. Weddle, J. Wolf *, R. Sills*

MeSH headings : Ecology / methods; Ecology / trends; Editorial Policies; Pathology, Veterinary / methods; Pathology, Veterinary / trends; Periodicals as Topic
TL;DR: The establishment of a section on Environmental Pathobiology will provide opportunities for diagnosticians, pathologists, pathology residents, and scientists to learn and publish about current mechanistic research and various types of diagnostic methods used to assess and clarify disease processes caused by exposure to environmental contaminants. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2013 personal communication

From Bipeds to an Honorary Member of the American College of Veterinary Pathologists

Meuten, D. J., Law, J. M., Stromberg, P. C., & Cullen, J. M. (2013, May).

By: D. Meuten n, J. Law n, P. Stromberg * & J. Cullen n

MeSH headings : Animals; Autopsy; Communication; Humans; Pathology, Veterinary / methods; Terminology as Topic
TL;DR: If the word autopsy is more acceptable to pet owners than necropsy, then it is hoped all clinicians will use this term, written and verbally, as they explain how further examination of their pet is essential to help other pets and researchers. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Immunohistochemical characterization of the hepatic progenitor cell compartment in medaka (oryzias latipes) following hepatic injury

Journal of Comparative Pathology, 149(4), 434–445.

By: A. Wettere  n, S. Kullmam, D. Hinton* & J. Law n

MeSH headings : Animals; Animals, Genetically Modified; Cell Differentiation / physiology; Disease Models, Animal; Female; Hepatocytes / cytology; Hepatocytes / ultrastructure; Immunohistochemistry; Liver / injuries; Liver Regeneration / physiology; Male; Microscopy, Electron, Transmission; Oryzias; Stem Cells / cytology; Stem Cells / ultrastructure
TL;DR: The present study defines the process of OC differentiation in fish liver using histopathology, immunohistochemistry and transmission electron microscopy and confirms the presence of, and support the putative bipotential lineage capabilities of, the fish OC. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2013 journal article

Phenotypic Characterization of Transgenic Japanese Medaka (Oryzias latipes) That Express a Red Fluorescent Protein in Hepatocytes

Toxicologic Pathology, 42(3), 616–621.

By: A. Van Wettere n, J. Law n, D. Hinton* & S. Kullman n 

author keywords: transgenic medaka; Oryzias latipes; liver fatty acid binding protein; inclusion; red fluorescent protein
MeSH headings : Animals; Animals, Genetically Modified / genetics; Animals, Genetically Modified / metabolism; Cloning, Molecular; Embryo, Nonmammalian; Fatty Acid-Binding Proteins / genetics; Female; Hepatocytes / chemistry; Hepatocytes / metabolism; Liver / chemistry; Liver / metabolism; Luminescent Proteins / chemistry; Luminescent Proteins / genetics; Luminescent Proteins / metabolism; Male; Oryzias / genetics; Oryzias / metabolism; Phenotype
TL;DR: The phenotype of a transgenic medaka strain that expresses a red fluorescent protein (RFP) in hepatocytes was characterized using light and fluorescence microscopy, immunohistochemistry, and transmission electron microscopy (TEM). (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Crossref, Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 journal article

Polyomavirus-Associated Nephritis in 2 Horses

Veterinary Pathology, 50(5), 769–774.

By: S. Jennings n, A. Wise*, V. Nickeleit*, R. Maes*, R. Cianciolo *, F. Piero*, J. Law n, Y. Kim n ...

author keywords: kidney; horse; myocarditis; nephritis; polyomavirus
MeSH headings : Animals; Blood Chemical Analysis / veterinary; Capsid Proteins / genetics; DNA Primers / genetics; Fatal Outcome; Female; Horse Diseases / immunology; Horse Diseases / pathology; Horse Diseases / virology; Horses; Immunocompromised Host / immunology; Immunoglobulin G / blood; Immunohistochemistry / veterinary; Kidney Cortex Necrosis / pathology; Kidney Cortex Necrosis / veterinary; Kidney Cortex Necrosis / virology; Male; Nephritis, Interstitial / pathology; Nephritis, Interstitial / veterinary; Nephritis, Interstitial / virology; Phylogeny; Polyomavirus / genetics; Polyomavirus Infections / pathology; Polyomavirus Infections / veterinary
TL;DR: 2 Standardbred horses with tubular necrosis and tubulointerstitial nephritis associated with productive equine polyomvirus infection that resembles BK polyomavirus nephropathy in immunocompromised humans are described. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2013 journal article

Repeated exposure of goldfish (Carassius auratus) to tricaine methanesulfonate (MS-222)

Journal of Zoo and Wildlife Medicine, 44(2), 340–347.

By: L. Posner n, G. Scott & J. Law

author keywords: Goldfish; MS-222; gills; pathology; minimum anesthetic concentration
MeSH headings : Aminobenzoates / administration & dosage; Aminobenzoates / adverse effects; Aminobenzoates / pharmacology; Anesthetics / administration & dosage; Anesthetics / adverse effects; Anesthetics / pharmacology; Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Fish Diseases / chemically induced; Gills / drug effects; Gills / pathology; Gills / ultrastructure; Goldfish
TL;DR: Goldfish in this study had an increased requirement for MS-222 following daily Exposure for 4 min but not following daily exposure for 2 min at a higher concentration, and the cause of this increased anesthetic need is not related to morphologic changes to the gills. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (Web of Science; OpenAlex)
Source: Crossref
Added: September 11, 2019

2012 journal article

Anchoring hepatic gene expression with development of fibrosis and neoplasia in a toxicant-induced fish model of liver injury

Toxicologic Pathology, 41(5), 1–17.

By: A. Van Wettere  n, J. Law n, D. Hinton* & S. Kullman n 

author keywords: dimethylnitrosamine; liver; fibrosis; neoplasia; medaka; Oryzias latipes; gene expression
MeSH headings : Animals; Chemical and Drug Induced Liver Injury / etiology; Chemical and Drug Induced Liver Injury / genetics; Chemical and Drug Induced Liver Injury / metabolism; Chemical and Drug Induced Liver Injury / pathology; Dimethylnitrosamine / toxicity; Disease Models, Animal; Female; Fish Proteins / chemistry; Fish Proteins / genetics; Fish Proteins / metabolism; Gene Expression; Immunohistochemistry; Liver / drug effects; Liver / metabolism; Liver / pathology; Liver Cirrhosis / chemically induced; Liver Cirrhosis / genetics; Liver Cirrhosis / metabolism; Liver Cirrhosis / pathology; Male; Microscopy, Electron, Transmission; Oryzias; Phenotype
TL;DR: This study identified a group of candidate genes likely to be involved in the development of hepatic fibrosis and demonstrated that the TGF-β pathway likely plays a major role in the pathogenesis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 journal article

Clinical and Pathological Effects of the Polyopisthocotylean Monogenean, Gamacallum macroura in White Bass

JOURNAL OF AQUATIC ANIMAL HEALTH, 24(4), 251–257.

By: E. Clarke n, C. Harms n , J. Law n, J. Flowers n, V. Williams n, B. Ring n, A. McGinty n, M. Hopper n, C. Sullivan n

MeSH headings : Animals; Bass; Fish Diseases / parasitology; Fish Diseases / pathology; Platyhelminths / classification; Platyhelminths / isolation & purification; Trematode Infections / parasitology; Trematode Infections / veterinary
TL;DR: Pale-gilled and healthy white bass were selected with no particular attention to condition for venipuncture and euthanasia for postmortem examination, including parasite counts from gills, and monogeneans, identified as Gamacallum macroura, were found on the gills. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 journal article

Neoplastic and Nonneoplastic Liver Lesions Induced by Dimethylnitrosamine in Japanese Medaka Fish

VETERINARY PATHOLOGY, 49(2), 372–385.

By: K. Hobbie*, A. DeAngelo*, M. George * & J. Law n

author keywords: Japanese medaka; Oryzias latipes; hepatocarcinogenesis; dimethylnitrosamine; aquatic animal models; comparative carcinogenesis; alternative animal models
MeSH headings : Animals; Animals, Genetically Modified; Biliary Tract Neoplasms / chemically induced; Biliary Tract Neoplasms / pathology; Biliary Tract Neoplasms / veterinary; Biomarkers / metabolism; Carcinogenicity Tests; Carcinogens / toxicity; Carcinoma, Hepatocellular / chemically induced; Carcinoma, Hepatocellular / pathology; Carcinoma, Hepatocellular / veterinary; Cell Proliferation / drug effects; Chemical and Drug Induced Liver Injury / pathology; Chemical and Drug Induced Liver Injury / veterinary; Dimethylnitrosamine / toxicity; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Fish Diseases / chemically induced; Fish Diseases / pathology; Liver / drug effects; Liver Neoplasms / chemically induced; Liver Neoplasms / pathology; Liver Neoplasms / veterinary; Male; Mutagenicity Tests; Oryzias; Rats; Signal Transduction; Species Specificity; Transforming Growth Factor beta / metabolism
TL;DR: Small fish models have been used for decades in carcinogenicity testing, but the pre-neoplastic and neoplastic commonalities between the two models are largely unknown, with special emphasis on the TGF-β pathway and its corresponding role in DMN-induced hepatic neoplasia. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Rapid decreases in salinity, but not increases, lead to immune dysregulation in Nile tilapia,Oreochromis niloticus(L.)

Journal of Fish Diseases, 36(4), 389–399.

By: K. Choi n, W. Cope n , C. Harms n  & J. Law n

author keywords: IL-1; immunopathology; phagocytosis assay; salinity stress; TGF-; tilapia
MeSH headings : Animals; Cichlids / immunology; Cytokines; Dose-Response Relationship, Drug; Gene Expression Regulation / drug effects; Gene Expression Regulation / immunology; Interleukin-1beta / genetics; Interleukin-1beta / metabolism; RNA, Messenger / genetics; RNA, Messenger / metabolism; Salinity; Sodium Chloride / administration & dosage; Sodium Chloride / toxicity; Time Factors; Transforming Growth Factor beta / genetics; Transforming Growth Factor beta / metabolism; Water / chemistry
TL;DR: In total, acute salinity changes appeared to trigger reactive dysregulation of the immune response in tilapia, a situation which, when combined with additional co-occurring stressors such as sudden changes in temperature and/or dissolved oxygen, could make fish more susceptible to infectious diseases. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2011 journal article

Assessing water quality suitability for shortnose sturgeon in the Roanoke River, North Carolina, USA with an in situ bioassay approach

JOURNAL OF APPLIED ICHTHYOLOGY, 27(1), 1–12.

By: W. Cope n , F. Holliman*, T. Kwak n , N. Oakley*, P. Lazaro n, D. Shea n , T. Augspurger*, J. Law n ...

Contributors: W. Cope n , F. Holliman*, T. Kwak n , N. Oakley*, P. Lazaro n, D. Shea n , T. Augspurger*, J. Law n, J. Henne*, K. Ware*

TL;DR: This study indicates that conditions in the Roanoke River are incongruous with the needs of juvenile shortnose sturgeon and that fathead minnows, commonly used standard toxicity test organisms, do not adequately predict the sensitivity of shortn Nose Sturgeon. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2011 journal article

Clinical report: hyperplastic adipose lids in mackerel scad, Decapterus macarellus (Cuvier)

Journal of Fish Diseases, 34(12), 921–925.

By: S. Boylan*, C. Harms n , T. Waltzek *, J. Law n, M. Garner, J. Cassell*, M. Fatzinger*, P. Govett*

author keywords: hyperplasia; mackerel scad; adipose lids
MeSH headings : Adipose Tissue / pathology; Animals; Eyelid Diseases / etiology; Eyelid Diseases / veterinary; Fish Diseases / etiology; Fish Diseases / pathology; Hypertrophy / etiology; Hypertrophy / veterinary; Perciformes
TL;DR: This exhibition highlights the efforts towards in-situ applicability of EMMARM, which aims to provide real-time information about infectious disease and its effects on wildlife and human health. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries
Added: July 21, 2019

2011 journal article

Necropsy or Autopsy? It’s All About Communication!

Veterinary Pathology, 49(2), 271–272.

By: M. Law n, P. Stromberg *, D. Meuten n & J. Cullen n

MeSH headings : Animals; Autopsy; Communication; Humans; Pathology, Veterinary / methods; Terminology as Topic
TL;DR: Several of us have decided that communication is more important than tradition and postmortem examination of nonhumans was proscribed from using the term and was designated ‘‘necropsy’. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, Web Of Science
Added: August 6, 2018

2011 article

Pathology in Practice

Tobias, J. R., Barnes, H. J., & Law, J. M. H. (2011, October 15). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 239, pp. 1065–1067.

By: J. Tobias n, H. Barnes & J. Law

MeSH headings : Adenocarcinoma / pathology; Adenocarcinoma / veterinary; Animals; Chickens; Female; Liver Neoplasms / secondary; Liver Neoplasms / veterinary; Oviducts / pathology; Peritoneal Neoplasms / secondary; Peritoneal Neoplasms / veterinary; Poultry Diseases / pathology
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Pseudosonsinotrema megalorchis n. sp. (Digenea: Pleurogenidae) from the Paramo Marsupial Frog, Gastrotheca pseustes (Anura: Hemiphractidae), Ecuador

COMPARATIVE PARASITOLOGY, 78(1), 15–20.

By: J. Flowers*, M. Law & S. Carvajal-Endara *

author keywords: Pseudosonsinotrema megalorchis n. sp.; Digenea; Pleurogenidae; Paramo marsupial frog; Gastrotheca pseustes; Anura; Hemiphractidae; Ecuador
TL;DR: The intense host inflammatory reaction and the relatively low fecundity of specimens suggest that G. pseustes is not the natural host of P. megalorchis, the first report of this digenean genus from Ecuador and the first reported of helminths from G. comb. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Quasi-one-dimensional antiferromagnetism and multiferroicity in CuCrO4

PHYSICAL REVIEW B, 84(1).

By: J. Law*, P. Reuvekamp*, R. Glaum *, C. Lee n, J. Kang n, M. Whangbo n, R. Kremer *

Source: Web Of Science
Added: August 6, 2018

2011 journal article

Two Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Paralogs are Required for Normal Development in Zebrafish

The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology, 294(9), 1511–1524.

By: L. Ott  n, Z. Mcdowell n, P. Turner n, J. Law n, K. Adler n, J. Yoder n , S. Jones n 

author keywords: MARCKS; zebrafish; development
MeSH headings : Amino Acid Sequence; Animals; Embryo, Nonmammalian / cytology; Embryo, Nonmammalian / metabolism; Intracellular Signaling Peptides and Proteins / antagonists & inhibitors; Intracellular Signaling Peptides and Proteins / genetics; Intracellular Signaling Peptides and Proteins / metabolism; Membrane Proteins / antagonists & inhibitors; Membrane Proteins / genetics; Membrane Proteins / metabolism; Molecular Sequence Data; Morpholinos / pharmacology; Multigene Family; Myristoylated Alanine-Rich C Kinase Substrate; Phenotype; Phylogeny; Sequence Homology, Amino Acid; Zebrafish / genetics; Zebrafish / growth & development
TL;DR: It is demonstrated that Marcksa and Marcksb are required for normal zebrafish development and suggested that zebra fish are a suitable model to further study MARCKS function. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2010 journal article

Cellular Proliferation, Cell Death, and Liver Histology in Gambusia affinis After Dietary Exposure to Benzidine and 2-Aminofluorene

INTERNATIONAL JOURNAL OF TOXICOLOGY, 29(3), 247–258.

By: S. Lentz*, R. Eversole*, J. Law n & J. Means*

author keywords: arylamines; cell proliferation; apoptosis; toxicity; G affinis; PCNA; TUNEL
MeSH headings : Algorithms; Animals; Benzidines / administration & dosage; Benzidines / toxicity; Carcinogenicity Tests / methods; Carcinogens / administration & dosage; Carcinogens / toxicity; Cell Death / drug effects; Cell Proliferation / drug effects; Cyprinodontiformes; Diet; Dose-Response Relationship, Drug; Fluorenes / administration & dosage; Fluorenes / toxicity; In Situ Nick-End Labeling; Liver / drug effects; Liver / metabolism; Liver / pathology; Male; Models, Animal; Proliferating Cell Nuclear Antigen / metabolism; Random Allocation; Statistics, Nonparametric; Time Factors
TL;DR: A mammalian-like response to 2AF and BZ in G affinis liver is demonstrated, demonstrating an increase in oval/spindle cell proliferation and altered foci formation in the treated groups compared with controls. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Evaluation of the relationship between lesions in the gastroduodenal region and cyclooxygenase expression in clinically normal dogs

American Journal of Veterinary Research, 71(6), 630–635.

By: J. Wooten n, B. Lascelles  n, V. Cook n, J. Law n & A. Blikslager n 

Contributors: J. Wooten n, B. Lascelles  n, V. Cook n, J. Law n & A. Blikslager n 

MeSH headings : Animals; Blotting, Western / veterinary; Cyclooxygenase 1 / biosynthesis; Cyclooxygenase 2 / biosynthesis; Dog Diseases / enzymology; Dog Diseases / pathology; Dogs / metabolism; Duodenitis / enzymology; Duodenitis / pathology; Duodenitis / veterinary; Duodenum / enzymology; Duodenum / pathology; Female; Gastritis / enzymology; Gastritis / pathology; Gastritis / veterinary; Immunohistochemistry / veterinary; Intestinal Mucosa / enzymology; Intestinal Mucosa / pathology; Male; Pylorus / enzymology; Pylorus / pathology; Statistics, Nonparametric
TL;DR: Dogs that appear to be clinically normal may have underlying gastroduodenal lesions associated with upregulation of COX-2, and practitioners should be aware of this potential situation when prescribing COX inhibitors. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2010 journal article

Exposure to the synthetic FXR agonist GW4064 causes alterations in gene expression and sublethal hepatotoxicity in eleutheroembryo medaka (Oryzias latipes)

TOXICOLOGY AND APPLIED PHARMACOLOGY, 243(1), 111–121.

By: D. Howarth*, S. Law n, J. Law n, J. Mondon *, S. Kullman n  & D. Hinton*

author keywords: Farnesoid X receptor; Liver; Medaka; Toxicity; Eleutheroembryo
MeSH headings : Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Embryo, Nonmammalian / drug effects; Embryo, Nonmammalian / physiology; Female; Gene Expression Regulation, Developmental / drug effects; Isoxazoles / pharmacology; Liver / drug effects; Liver / pathology; Liver / ultrastructure; Male; Oryzias / embryology; Protein Isoforms; Receptors, Cytoplasmic and Nuclear / agonists; Yolk Sac
TL;DR: This report of hepatobiliary injury following GW4064 exposure extends previous investigations of the intrahepatic biliary system in medaka, reveals sensitivity to toxicant exposure, and illustrates the need for added resolution in detection and interpretation of toxic responses in this vertebrate. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

Expression of thioredoxin during progression of hamster and human cholangiocarcinoma

CANCER SCIENCE, 101(1), 281–288.

By: B. Yoon n, Y. Kim*, J. Yi*, M. Kang *, J. Jang*, K. Joo*, Y. Kim n, J. Law n, D. Kim*

MeSH headings : Animals; Bile Duct Neoplasms / chemistry; Bile Duct Neoplasms / pathology; Bile Ducts, Intrahepatic; Blotting, Western; Cholangiocarcinoma / chemistry; Cholangiocarcinoma / pathology; Cricetinae; Disease Progression; Humans; Immunohistochemistry; Mesocricetus; Precancerous Conditions / chemistry; Precancerous Conditions / pathology; Thioredoxins / analysis; Thioredoxins / physiology
TL;DR: The results strongly suggested that the redox regulatory function of Trx plays an important role in bile duct cell transformation and tumor progression during cholangiocarcinogenesis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Gross and histologic evaluation of 5 suture materials in the skin and subcutaneous tissue of the california sea hare (Aplysia californica)

Journal of the American Association for Laboratory Animal Science, 49(1), 64–68.

By: E. Anderson, A. Davis, J. Law, G. Lewbart , L. Christian & C. Harms 

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

LONG-TERM TRENDS IN LIVER NEOPLASMS IN BROWN BULLHEAD IN THE BUFFALO RIVER, NEW YORK, USA

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 29(8), 1748–1754.

By: D. Lauren*, D. Hinton*, M. Law n, M. Sorensen*, J. Lyndall*, V. Magar*, M. Nielsen*

author keywords: Natural attenuation; Sediment; Brown bullhead; Histopathology; Buffalo River
MeSH headings : Animals; Environmental Monitoring; Epidemiological Monitoring; Fish Diseases / epidemiology; Fish Diseases / pathology; Ictaluridae; Liver / pathology; Liver Neoplasms / epidemiology; Liver Neoplasms / pathology; Liver Neoplasms / veterinary; New York; Rivers; Water Pollution
TL;DR: Natural attenuation of water and sediment quality are the most likely causes for the decrease in liver tumors in brown bullhead collected from three reaches of the Buffalo River. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Aquatic animal models of human disease: Selected papers and recommendations from the 4th Conference

Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 149(2), 121–128.

By: D. Hinton*, R. Hardman*, S. Kullman n , J. Law n, M. Schmale*, R. Walter*, R. Winn*, J. Yoder n 

MeSH headings : Animals; Disease Models, Animal; Fishes; Humans; Mollusca
TL;DR: Of increasing importance are contributions of aquatic invertebrates and fishes to the detection of toxic responses from: metal mining and smelting impacts, polycyclic aromatichydrocarbons and persistent organic pollutants and their adverse effects in harbors and coastal estuaries, including the verification of remediation processes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2009 journal article

Characterizing eversion syndrome in captive scyphomedusa jellyfish

American Journal of Veterinary Research, 70(9), 1087–1093.

By: K. Freeman n, G. Lewbart* , W. Robarge*, C. Harms* , J. Law* & M. Stoskopf*

MeSH headings : Animal Feed; Animals; Digestive System Abnormalities / pathology; Digestive System Abnormalities / veterinary; Scyphozoa / anatomy & histology; Scyphozoa / physiology; Syndrome
TL;DR: It is suggested that eversion syndrome is a complex phenomenon associated with degenerative changes of the bell matrix and Striated muscle degeneration and necrosis and extracellular matrix (mesoglea) degeneration were evident on histologic examination of affected jellyfish. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
14. Life Below Water (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 journal article

Enhanced transcription of complement and coagulation genes in the absence of adaptive immunity

Molecular Immunology, 46(7), 1505–1516.

By: D. Jima n, R. Shah n, T. Orcutt n, D. Joshi*, J. Law n, G. Litman*, N. Trede*, J. Yoder n 

author keywords: Zebrafish; Mouse; rag1; Innate immunity; SCID
MeSH headings : Adaptation, Physiological / genetics; Adaptation, Physiological / immunology; Animals; Animals, Genetically Modified; Blood Coagulation Factors / genetics; Blood Coagulation Factors / metabolism; Complement C4 / genetics; Complement C4 / metabolism; Complement System Proteins / genetics; Complement System Proteins / metabolism; Female; Gene Expression Profiling; Genes, RAG-1 / physiology; Immunity / genetics; Immunity / physiology; Intestinal Mucosa / metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oligonucleotide Array Sequence Analysis; Transcription, Genetic; Up-Regulation; Zebrafish
TL;DR: It is hypothesized that the rag1(-/-) zebrafish may possess an "enhanced" innate immune response to compensate for the lack of an adaptive immune system. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2009 article

Finfish and aquatic invertebrate pathology resources for now and the future

Spitsbergen, J. M., Blazer, V. S., Bowser, P. R., Cheng, K. C., Cooper, K. R., Cooper, T. K., … Wolf, J. C. (2009, March). COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, Vol. 149, pp. 249–257.

By: J. Spitsbergen*, V. Blazer *, P. Bowser*, K. Cheng *, K. Cooper *, T. Cooper*, S. Frasca*, D. Groman* ...

author keywords: Fish pathology; Aquatic model; Pathology training program; Invertebrate pathology; Standardized diagnostic criteria; Environmental sentinel; Histopathology; Aquatic animal medicine
MeSH headings : Animals; Aquaculture / methods; Environmental Monitoring; Fishes; Invertebrates; Pathology / education; Pathology / standards; Pathology / trends
TL;DR: Several factors must change to maximize the use, understanding, and protection of important aquatic species: improvements in databases of abnormalities across species; standardization of diagnostic criteria for proliferative and nonproliferative lesions; and more uniform and rigorous training in aquatic morphologic pathology. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Recommendations for control of pathogens and infectious diseases in fish research facilities

Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 149(2), 240–248.

By: M. Kent *, S. Feist*, C. Harper*, S. Hoogstraten-Miller*, J. Law n, J. Sánchez-Morgado *, R. Tanguay *, G. Sanders*, J. Spitsbergen*, C. Whipps *

author keywords: Fish; Pathogen; Research; Zebrafish; Medaka; Mycobacteria
MeSH headings : Animals; Aquaculture / methods; Communicable Diseases / microbiology; Fish Diseases / microbiology; Fish Diseases / prevention & control; Fishes; Health Planning Guidelines; Infection Control / methods
TL;DR: Recommendations and strategies to avoid or minimize the impacts of infectious agents in fishes maintained in the research setting and the goal of documenting, detecting, and excluding pathogens in fish is just as important as in mammalian research models are presented. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Crossref
Added: July 27, 2019

2009 journal article

Toward a molecular equivalent dose: Use of the medaka model in comparative risk assessment

Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 149(2), 141–151.

By: K. Hobbie n, A. DeAngelo, L. King, R. Winn & J. Law

author keywords: Risk assessment; Dose-response; DNA; Medaka; cll; Mutation; Adduct; DMN; Nitrosamines
MeSH headings : Animals; Animals, Genetically Modified; Carcinogens / metabolism; Carcinogens / pharmacology; Carcinogens / toxicity; DNA / genetics; DNA / isolation & purification; DNA Adducts / analysis; DNA Adducts / metabolism; Dimethylnitrosamine / metabolism; Dimethylnitrosamine / pharmacology; Dimethylnitrosamine / toxicity; Dose-Response Relationship, Drug; Guanine / analogs & derivatives; Guanine / analysis; Guanine / metabolism; Immunohistochemistry; Liver / drug effects; Liver / metabolism; Liver / pathology; Male; Models, Biological; Mutagenicity Tests; Mutation; Oryzias / genetics; Random Allocation; Rats; Rats, Inbred F344; Rats, Transgenic; Risk Assessment; Water Supply
TL;DR: While liver DNA adduct concentrations were similar in magnitude, mutant frequencies in the DMN-exposed medaka were up to 20 times higher than in the Big Blue rats, and future work with other compounds will generate a more complete picture of comparative dose response between different phyletic levels and will help guide risk assessors using "Alternative" models. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref
Added: August 6, 2018

2008 journal article

Cryotherapy for removal of a premaxillary mass from a chain pickerel using an over-the-counter wart remover

Exotic, DVM 10, 15–17.

By: C. Harms, L. Christian, O. Burrus, W. Hopkins, A. Pandiri, J. Law, K. Wolf, C. Butler, G. Lewbart

Source: NC State University Libraries
Added: April 24, 2021

2008 journal article

Cyclooxygenase expression and prostanoid production in pyloric and duodenal mucosae in dogs after administration of nonsteroidal anti-inflammatory drugs

American Journal of Veterinary Research, 69(4), 457–464.

By: J. Wooten n, A. Blikslager n , K. Ryan n, S. Marks n, J. Law n & B. Lascelles  n

Contributors: J. Wooten n, A. Blikslager n , K. Ryan n, S. Marks n, J. Law n & B. Lascelles  n

MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / pharmacology; Biopsy / veterinary; Blotting, Western / veterinary; Cross-Over Studies; Cyclooxygenase 1 / biosynthesis; Cyclooxygenase 2 / biosynthesis; Dogs / metabolism; Endoscopy / veterinary; Female; Gastric Mucosa / drug effects; Gastric Mucosa / enzymology; Gastric Mucosa / metabolism; Histocytochemistry / veterinary; Intestinal Mucosa / drug effects; Intestinal Mucosa / enzymology; Intestinal Mucosa / metabolism; Male; Prostaglandins / biosynthesis; Pyloric Antrum / drug effects; Pyloric Antrum / enzymology; Pyloric Antrum / metabolism; Random Allocation; Thromboxane B2 / metabolism
TL;DR: In dogs, prostanoid synthesis was greater in pyloric mucosa than it was in duodenal mucosa, compared with the effects of a selective COX-2 NSAID. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2008 chapter

Mechanisms of Cell Death

In Molecular and Biochemical Toxicology (pp. 287–318).

By: M. Law n & S. Elmore *

Source: Crossref
Added: July 27, 2019

2007 journal article

Acute hypoxia-reperfusion triggers immunocompromise in Nile tilapia

JOURNAL OF AQUATIC ANIMAL HEALTH, 19(2), 128–140.

By: K. Choi n, D. Lehmann n, C. Harms n  & J. Law n

MeSH headings : Animals; Aquaculture; Blood Chemical Analysis / veterinary; Blood Gas Analysis; Cichlids / blood; Cichlids / immunology; Cytokines / biosynthesis; Female; Hematologic Tests / veterinary; Hydrocortisone / blood; Hypoxia / blood; Hypoxia / immunology; Hypoxia / veterinary; Interleukin-1beta / biosynthesis; Male; Oxygen / pharmacology; Phagocytosis / drug effects; Reperfusion / veterinary; Time Factors; Transforming Growth Factor beta / biosynthesis
TL;DR: It is concluded that acute hypoxia triggered an overall downregulation of the immune system in the test fish, suggesting a possible factor in the pathogenesis of disease outbreaks in fish in which repeated, sublethal bouts of environmentally induced hypoxIA lead to increased disease susceptibility and individual mortalities rather than massive fish kills. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

Characterization of toxic effects of sediment-associated organic pollutants using the lambda transgenic medaka

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 41(22), 7830–7836.

By: J. Cachot *, M. Law*, D. Pottier*, L. Peluhet*, M. Norris*, H. Budzinski *, R. Winn*

MeSH headings : Animals; Animals, Genetically Modified; Benzo(a)pyrene / chemistry; DNA Mutational Analysis; Environmental Monitoring / methods; Fishes; Gene Expression Regulation, Developmental; Geologic Sediments / analysis; Homozygote; Liver / metabolism; Mutation; Organic Chemicals / chemistry; Oryzias / genetics; Polychlorinated Biphenyls / chemistry; Time Factors; Water Pollutants / analysis; Water Pollutants / chemistry
TL;DR: The benefits of medaka as a fish model for toxicological assessment and the benefits of the cII mutation assay for mutation detection combine to provide comprehensive assessment of a wide range of genotoxic and nongenotoxic effects of aquatic pollutants. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Multitiered Health Assessment of Atlantic Menhaden in the Pamlico River, North Carolina

Journal of Aquatic Animal Health, 19(4), 205–214.

By: A. Johnson*, J. Law n, C. Harms n  & J. Levine n 

MeSH headings : Actins / analysis; Animals; Blood Cell Count / veterinary; Blood Chemical Analysis / veterinary; Blood Proteins / analysis; Fish Diseases / epidemiology; Fish Diseases / mortality; Fish Diseases / pathology; Fishes / physiology; Liver / physiopathology; North Carolina / epidemiology; Prevalence; Rivers; Skin / pathology; Skin Diseases / epidemiology; Skin Diseases / pathology; Skin Diseases / veterinary; Skin Ulcer / epidemiology; Skin Ulcer / pathology; Skin Ulcer / veterinary; Spleen / physiopathology; Transforming Growth Factor beta / analysis
TL;DR: Atlantic menhaden with ulcerative skin lesions had significantly higher liver somatic indices, neutrophil and monocyte percentages, and splenic mononuclear cell TGF-beta mRNA levels than did fish without lesions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2007 journal article

Polychlorinated Biphenyl Exposure Causes Gonadal Atrophy and Oxidative Stress in Corbicula fluminea Clams

Toxicologic Pathology, 35(3), 356–365.

By: D. Lehmann n, J. Levine n  & J. Law n

author keywords: PCB; polychlorinated biphenyl; oxidative stress; gonadal atrophy; Corbicula clams; Aroclor; antioxidant
MeSH headings : Animals; Aroclors / toxicity; Biomarkers / analysis; Corbicula; Dose-Response Relationship, Drug; Gonads / drug effects; Gonads / pathology; Oxidative Stress / drug effects; Polychlorinated Biphenyls / toxicity; Random Allocation; Time Factors; Water Pollutants, Chemical / toxicity
TL;DR: It is indicated that oxidative mechanisms play a significant role in the decreased health of these clams due to exposure to Aroclor 1260, and changes in the gonads of exposed clams suggest that a serious threat to bivalve reproduction exists due to PCB exposure. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2006 journal article

A quantitative real-time RT-PCR assay to measure TGF-β mRNA and its correlation with hematologic, plasma chemistry and organo-somatic indices responses in triamcinolone-treated Atlantic menhaden, Brevoortia tyrannus

Developmental & Comparative Immunology, 30(5), 473–484.

By: A. Johnson n, C. Harms n , J. Levine n  & J. Law n

author keywords: Atlantic menhaden; triamcinolone; TGF-beta; health indices; hematology; plasma chemistry; real-time RT-PCR
MeSH headings : Animals; Anti-Inflammatory Agents / pharmacology; Base Sequence; Blood Glucose / analysis; Fish Diseases / blood; Fish Diseases / immunology; Fish Diseases / metabolism; Fishes / blood; Fishes / immunology; Fishes / metabolism; Leukocytes, Mononuclear / drug effects; Leukocytes, Mononuclear / metabolism; Liver / drug effects; Liver / metabolism; Molecular Sequence Data; Plasma; RNA, Messenger / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Skin Ulcer / immunology; Skin Ulcer / metabolism; Skin Ulcer / veterinary; Spleen / drug effects; Spleen / metabolism; Transforming Growth Factor beta / metabolism; Triamcinolone Acetonide / pharmacology
TL;DR: A quantitative real-time reverse transcription polymerase chain reaction (RT-PCR) assay was developed to measure transforming growth factor-beta (TGF-beta) in Atlantic menhaden, an estuarine-dependent species plagued by ulcerative skin lesions in the estuaries along the eastern United States. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2006 chapter

Chapter 7: Bivalves

In G. Lewbart (Ed.), Invertebrate Medicine (pp. 91–115). Ames, Iowa: Blackwell Publishing.

By: J. Levine, M. Law & F. Corsin

Ed(s): G. Lewbart

Source: NC State University Libraries
Added: April 24, 2021

2006 journal article

Dynamic Gene Expression Changes Precede Dioxin-Induced Liver Pathogenesis in Medaka Fish

Toxicological Sciences, 89(2), 524–534.

By: D. Volz, D. Hinton, J. Law & S. Kullman* 

author keywords: medaka; dioxin; liver; aryl hydrocarbon receptor; gene expression; transcription
MeSH headings : Animals; Cytochrome P-450 CYP1A1 / genetics; Cytochrome P-450 CYP1A2 / genetics; Dose-Response Relationship, Drug; Gene Expression / drug effects; Gene Expression Profiling; Injections, Intraperitoneal; Liver / drug effects; Liver / metabolism; Liver / pathology; Male; Oligonucleotide Array Sequence Analysis; Oryzias; Polychlorinated Dibenzodioxins / toxicity; Receptors, Aryl Hydrocarbon / genetics; Reverse Transcriptase Polymerase Chain Reaction; Time Factors
TL;DR: The data suggest that the cellular response to dioxin involves both AHRE- and non-AHRE-mediated transcription, and that coupling gene expression profiling with analysis of morphologic pathogenesis is essential for establishing temporal relationships between transcriptional changes, toxicity, and adaptation to hepatic injury. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2006 journal article

Evaluation of the gross and histologic reactions to five commonly used suture materials in the skin of the African clawed frog (Xenopus laevis)

Journal of the American Association for Laboratory Animal Science, 45(6), 22–26.

By: A. Tuttle, J. Law, C. Harms , G. Lewbart  & S. Harvey

Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) Induces Organ- Specific Differential Gene Expression in Male Japanese Medaka (Oryzias latipes)

Toxicological Sciences, 85(1), 572–584.

By: D. Volz *, D. Bencic, D. Hinton, J. Law & S. Kullman* 

author keywords: Japanese medaka; TCDD; gene expression; brain; liver; testis
MeSH headings : Animals; Brain / drug effects; Brain / metabolism; Brain / pathology; Environmental Pollutants / toxicity; Gene Expression / drug effects; Gene Expression Profiling; Injections, Intraperitoneal; Liver / drug effects; Liver / metabolism; Liver / pathology; Male; Oligonucleotide Array Sequence Analysis; Organ Specificity; Oryzias / genetics; Polychlorinated Dibenzodioxins / toxicity; Reverse Transcriptase Polymerase Chain Reaction; Testis / drug effects; Testis / metabolism; Testis / pathology
TL;DR: In this study, suppression subtractive hybridization was exploited as a screening tool to assess qualitative gene expression changes in whole brain, liver, and testis of adult male Japanese medaka exposed for 48 h to a single intraperitoneal-injected dose of TCDD. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2005 journal article

Demonstration of toxicity to fish and to mammalian cells by Pfiesteria species: Comparison of assay methods and strains

Proceedings of the National Academy of Sciences, 102(9), 3471–3476.

By: J. Burkholder n, A. Gordon n, P. Moeller n, J. Law n, K. Coyne  n, A. Lewitus n, J. Ramsdell n, H. Marshall n ...

author keywords: toxigenic dinoflagellates; Pfiesteria piscicida; Pfiesteria shumwayae
MeSH headings : Animals; Bacterial Toxins / toxicity; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Fishes / microbiology; Magnetic Resonance Spectroscopy; Mammals / microbiology; Pfiesteria piscicida / pathogenicity; Polymerase Chain Reaction
TL;DR: The data show the importance of testing multiple strains when assessing the potential for toxicity at the genus or species level, using appropriate culturing techniques and assays. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (Web of Science; OpenAlex)
Sources: Crossref, Web Of Science
Added: August 6, 2018

2003 journal article

Application of multiple sublethal stress indicators to assess the health of fish in Pamlico Sound following extensive flooding

Estuaries, 26(5), 1365–1382.

By: S. Adams*, M. Greeley*, J. Law n, E. Noga n & J. Zelikoff *

TL;DR: Flooding from the 1999 hurricanes may have contributed to the short-term health and condition of finfish species in Pamlico Sound and also influenced longer-term recovery and ecological status of this system. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018

2003 article

Percutaneous ultrasound-guided cholecystocentesis in healthy cats

JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 17, pp. 298–303.

By: K. Savary-Bataille, S. Bunch*, K. Spaulding*, M. Jackson*, J. Mac Law & M. Stebbins*

author keywords: bile; cholangiohepatitis; cholangitis; feline inflammatory liver disease; Helicobacter species; liver
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Evaluation of the tissue reactions in the skin and body wall of koi (Cyprinus carpio) to five suture materials

VETERINARY RECORD, 151(11), 324-+.

By: C. Hurty n, D. Brazik n, J. Law n, K. Sakamoto * & G. Lewbart n 

MeSH headings : Animals; Biocompatible Materials / adverse effects; Carps; Skin / pathology; Surgery, Veterinary / trends; Sutures
TL;DR: Five different suture materials (silk, monofilament nylon, polyglyconate, polyglactin 910, and chromic gut) were placed in the skin and body wall of 10 Doitsu (scaleless) koi and induced intense inflammatory reactions which did not subside if the suture remained in the tissue. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 journal article

Hypercalcemia and high parathyroid hormone-related protein concentration associated with malignant melanoma in a dog

JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 221(2), 263-+.

By: B. Pressler n, D. Rotstein*, J. Law*, T. Rosol, B. LeRoy, B. Keene*, M. Jackson*

MeSH headings : Animals; Dog Diseases / blood; Dog Diseases / etiology; Dogs; Fatal Outcome; Hypercalcemia / etiology; Hypercalcemia / veterinary; Male; Melanoma / complications; Melanoma / metabolism; Melanoma / veterinary; Mouth Neoplasms / complications; Mouth Neoplasms / metabolism; Mouth Neoplasms / veterinary; Parathyroid Hormone-Related Protein; Proteins / metabolism
TL;DR: A 12-year-old Cocker Spaniel with an oral malignant melanoma was evaluated for progressive lethargy and anorexia, andSerum parathyroid hormone-related protein concentration was markedly high, and the melanoma had moderate to marked immunostaining for this protein. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Prostatic pythiosis in a dog

JOURNAL OF VETERINARY INTERNAL MEDICINE, 16(5), 598–602.

By: G. Jaeger n, D. Rotstein n & J. Law n

Source: Web Of Science
Added: August 6, 2018

2001 journal article

Chylous abdominal effusion in a cat with feline infectious peritonitis

JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION, 37(1), 35–40.

By: K. Savary, R. Sellon* & J. Law*

MeSH headings : Animals; Ascitic Fluid / pathology; Ascitic Fluid / veterinary; Cat Diseases / diagnosis; Cats; Chylous Ascites / diagnosis; Chylous Ascites / veterinary; Diagnosis, Differential; Feline Infectious Peritonitis / diagnosis; Male
TL;DR: A 10-year-old cat was diagnosed with chyloperitoneum based on the effusion characteristics and feline coronavirus serology was positive, and the owner elected euthanasia due to suspected feline infectious peritonitis (FIP). (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2001 article

Differential diagnosis of ulcerative lesions in fish

Law, M. (2001, October). ENVIRONMENTAL HEALTH PERSPECTIVES, Vol. 109, pp. 681–686.

By: M. Law

author keywords: Atlantic menhaden; Brevoortia tyrannus; epizootic ulcerative syndrome; fish; muscle necrosis; skin ulcers; ulcerative mycosis
UN Sustainable Development Goal Categories
14. Life Below Water (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Experimental infection of cats with Tritrichomonas foetus

American Journal of Veterinary Research, 62(11), 1690–1697.

By: J. Gookin* , M. Levy*, J. Law*, M. Papich* , M. Poore* & E. Breitschwerdt* 

MeSH headings : Animals; Antigens, Protozoan / analysis; Antiprotozoal Agents / administration & dosage; Antiprotozoal Agents / therapeutic use; Cat Diseases / drug therapy; Cat Diseases / parasitology; Cats; Cryptosporidiosis / complications; Cryptosporidiosis / drug therapy; Cryptosporidiosis / veterinary; Cryptosporidium / growth & development; Diarrhea / drug therapy; Diarrhea / parasitology; Diarrhea / veterinary; Feces / parasitology; Female; Intestinal Diseases / drug therapy; Intestinal Diseases / parasitology; Intestinal Diseases / veterinary; Intestinal Mucosa / parasitology; Nitro Compounds; Parasite Egg Count / veterinary; Prednisolone / administration & dosage; Prednisolone / therapeutic use; Protozoan Infections / complications; Protozoan Infections / drug therapy; Protozoan Infections, Animal; Specific Pathogen-Free Organisms; Thiazoles / administration & dosage; Thiazoles / therapeutic use; Tritrichomonas foetus
TL;DR: After experimental inoculation in cats, T. foetus organisms colonize the ileum, cecum, and colon, reside in close contact with the epithelium, and are associated with transient diarrhea that is exacerbated by coexisting cryptosporidiosis but not treatment with prednisolone. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

1998 journal article

Hepatotoxicity of the drinking water disinfection by-product, dichloroacetic acid, in the medaka small fish model

TOXICOLOGY LETTERS, 94(1), 19–27.

By: J. Law n, L. Lopez  n & A. DeAngelo*

author keywords: dichloroacetic acid; hepatotoxicity; hepatocellular carcinogenesis; drinking water disinfection by-products; liver carcinogenesis; Japanese medaka
MeSH headings : Animals; Carcinogenicity Tests; Dichloroacetic Acid / toxicity; Environmental Exposure; Glycogen / biosynthesis; Glycolysis; Liver / drug effects; Liver / enzymology; Liver / pathology; Mice; Oryzias; Rats; Risk Assessment; Water Supply
TL;DR: The results of this study strengthen the role of the Japanese medaka as a suitable species in carcinogenicity testing as well as its implementation in the risk assessment process for DCA across several phyletic levels. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1998 journal article

Molecular dosimetry of DNA adducts in the medaka small fish model

CARCINOGENESIS, 19(3), 515–518.

By: J. Law n, M. Bull n, J. Nakamura & J. Swenberg

MeSH headings : Animals; Carcinogenicity Tests; Carcinogens / toxicity; DNA Adducts; Dose-Response Relationship, Drug; Models, Biological; Oryzias / genetics
TL;DR: The results of this study show that, under these short-term exposure conditions, ethyl-DNA adducts appear to accumulate in medaka liver tissue in a sublinear fashion after aqueous exposure to DEN, suggesting critical DNA repair enzymes such as O6-alkylguanine DNA alkyltransferase are probably saturated at the 100 p.p.m. concentration level of DEN. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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