Jeffrey M Macdonald

Works (5)

Updated: April 5th, 2024 07:05

2022 journal article

Direct Detection of Glutathione Biosynthesis, Conjugation, Depletion and Recovery in Intact Hepatoma Cells


By: R. Jeffries n, S. Gomez n, J. Macdonald n & M. Gamcsik n

author keywords: glutathione; antioxidant; nuclear magnetic resonance spectroscopy; noninvasive; alkylating agent; metabolism
MeSH headings : Animals; Bioreactors; Bridged Bicyclo Compounds; Carcinoma, Hepatocellular; Glutathione / metabolism; Humans; Liver Neoplasms; Rats
TL;DR: Standard NMR techniques can directly monitor intracellular processes such as glutathione depletion with a time resolution of approximately < 2 min, and are demonstrated to be effective in alginate-encapsulated JM-1 hepatomas. (via Semantic Scholar)
Source: Web Of Science
Added: June 6, 2022

2018 journal article

Propylene Glycol in Free-Ranging Green Sea Turtle Plasma

Journal of Fish and Wildlife Management, 9(2), 617–623.

By: J. Niemuth n, C. Harms n, J. Macdonald n & M. Stoskopf n

author keywords: antifreeze; cold adaptation; green sea turtles; metabolomics; nuclear magnetic resonance spectroscopy; propylene glycol
TL;DR: The presence of propylene glycol in plasma of free-ranging apparently healthy green sea turtles Chelonia mydas and individuals impacted by cold stun syndrome is demonstrated and serves as a starting point for future characterization of lipid metabolism and glycolysis in green sea Turtles. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: December 31, 2018

2017 journal article

Pyruvate Kinase Inhibits Proliferation during Postnatal Cerebellar Neurogenesis and Suppresses Medulloblastoma Formation

CANCER RESEARCH, 77(12), 3217–3230.

By: K. Tech n, A. Tikunov n, H. Farooq*, A. Morrissy*, J. Meidinger*, T. Fish*, S. Green n, H. Liu* ...

MeSH headings : Animals; Blotting, Western; Cell Proliferation; Cerebellar Neoplasms / enzymology; Cerebellar Neoplasms / pathology; Cerebellum / enzymology; Chromatography, Liquid; Humans; Immunohistochemistry; Mass Spectrometry; Medulloblastoma / enzymology; Medulloblastoma / pathology; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Neural Stem Cells / enzymology; Neural Stem Cells / pathology; Neurogenesis / physiology; Polymerase Chain Reaction; Pyruvate Kinase / metabolism
TL;DR: Findings show that distal and proximal disruptions of glycolysis have opposite effects on proliferation, and that efforts to block the oncogenic effect of aerobic glyCOlysis must target reactions upstream of PKM. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

In vivo MR studies of glycine and glutathione metabolism in a rat mammary tumor

NMR IN BIOMEDICINE, 25(2), 271–278.

By: P. Thelwall*, N. Simpson*, Z. Rabbani*, M. Clark*, R. Pourdeyhimi n, J. Macdonald n, S. Blackband*, M. Gamcsik n

author keywords: glutathione; MR; serine; metabolism; trans-sulfuration
MeSH headings : Animals; Carbon Isotopes; Female; Glutathione / metabolism; Glycine / metabolism; Magnetic Resonance Spectroscopy / methods; Mammary Neoplasms, Animal / metabolism; Mammary Neoplasms, Animal / pathology; Mass Spectrometry; Neoplasm Transplantation; Rats; Rats, Inbred F344; Subcutaneous Tissue / pathology
TL;DR: These studies demonstrate the use of MRI and MRS for the monitoring of tumor metabolic processes central to oxidative stress defense and show that isotope‐labeled serine is further metabolized via the trans‐sulfuration pathway. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

In vivo hypoxia and a fungal alcohol dehydrogenase influence the pathogenesis of invasive pulmonary aspergillosis

PLoS Pathogens, 7(7).

By: N. Grahl, S. Puttikamonkul, J. Macdonald, M. Gamcsik, L. Ngo, T. Hohl, R. Cramer

Source: NC State University Libraries
Added: August 6, 2018

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