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Works (5)
Updated: April 5th, 2024 07:05
2022 journal article
Direct Detection of Glutathione Biosynthesis, Conjugation, Depletion and Recovery in Intact Hepatoma Cells
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(9).
author keywords: glutathione; antioxidant; nuclear magnetic resonance spectroscopy; noninvasive; alkylating agent; metabolism
MeSH headings : Animals; Bioreactors; Bridged Bicyclo Compounds; Carcinoma, Hepatocellular; Glutathione / metabolism; Humans; Liver Neoplasms; Rats
TL;DR:
Standard NMR techniques can directly monitor intracellular processes such as glutathione depletion with a time resolution of approximately < 2 min, and are demonstrated to be effective in alginate-encapsulated JM-1 hepatomas.
(via Semantic Scholar)
open access via www.mdpi.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: June 6, 2022
2018 journal article
Propylene Glycol in Free-Ranging Green Sea Turtle Plasma
Journal of Fish and Wildlife Management, 9(2), 617–623.
author keywords: antifreeze; cold adaptation; green sea turtles; metabolomics; nuclear magnetic resonance spectroscopy; propylene glycol
TL;DR:
The presence of propylene glycol in plasma of free-ranging apparently healthy green sea turtles Chelonia mydas and individuals impacted by cold stun syndrome is demonstrated and serves as a starting point for future characterization of lipid metabolism and glycolysis in green sea Turtles.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: December 31, 2018
2017 journal article
Pyruvate Kinase Inhibits Proliferation during Postnatal Cerebellar Neurogenesis and Suppresses Medulloblastoma Formation
CANCER RESEARCH, 77(12), 3217–3230.
MeSH headings : Animals; Blotting, Western; Cell Proliferation; Cerebellar Neoplasms / enzymology; Cerebellar Neoplasms / pathology; Cerebellum / enzymology; Chromatography, Liquid; Humans; Immunohistochemistry; Mass Spectrometry; Medulloblastoma / enzymology; Medulloblastoma / pathology; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Neural Stem Cells / enzymology; Neural Stem Cells / pathology; Neurogenesis / physiology; Polymerase Chain Reaction; Pyruvate Kinase / metabolism
TL;DR:
Findings show that distal and proximal disruptions of glycolysis have opposite effects on proliferation, and that efforts to block the oncogenic effect of aerobic glyCOlysis must target reactions upstream of PKM.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
In vivo MR studies of glycine and glutathione metabolism in a rat mammary tumor
NMR IN BIOMEDICINE, 25(2), 271–278.
author keywords: glutathione; MR; serine; metabolism; trans-sulfuration
MeSH headings : Animals; Carbon Isotopes; Female; Glutathione / metabolism; Glycine / metabolism; Magnetic Resonance Spectroscopy / methods; Mammary Neoplasms, Animal / metabolism; Mammary Neoplasms, Animal / pathology; Mass Spectrometry; Neoplasm Transplantation; Rats; Rats, Inbred F344; Subcutaneous Tissue / pathology
TL;DR:
These studies demonstrate the use of MRI and MRS for the monitoring of tumor metabolic processes central to oxidative stress defense and show that isotope‐labeled serine is further metabolized via the trans‐sulfuration pathway.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
In vivo hypoxia and a fungal alcohol dehydrogenase influence the pathogenesis of invasive pulmonary aspergillosis
PLoS Pathogens, 7(7).
Source: NC State University Libraries
Added: August 6, 2018
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