Jenna Schirmer

Works (5)

Updated: April 5th, 2024 08:26

2019 journal article

Oral reserpine administration in horses results in low plasma concentrations that alter platelet biology

EQUINE VETERINARY JOURNAL, 51(4), 537–543.

By: J. Gilbertie  n, J. Davis*, G. Davidson n, A. McDonald n, J. Schirmer n & L. Schnabel n

author keywords: horse; reserpine; pharmacokinetics; tranquilisation; platelets; hypercoagulability
MeSH headings : Administration, Oral; Adrenergic Uptake Inhibitors / administration & dosage; Adrenergic Uptake Inhibitors / blood; Adrenergic Uptake Inhibitors / pharmacokinetics; Adrenergic Uptake Inhibitors / pharmacology; Animals; Area Under Curve; Blood Platelets / drug effects; Female; Half-Life; Horses / blood; Male; Reserpine / administration & dosage; Reserpine / blood; Reserpine / pharmacokinetics; Reserpine / pharmacology
TL;DR: Oral reserpine demonstrates low plasma concentrations and a prolonged half-life in horses and is likely due to serotonin release and re-uptake which primes platelets for activation and thromboxane B2 release. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: July 22, 2019

2018 journal article

Pharmacokinetics and ex vivo anti‐inflammatory effects of oral misoprostol in horses

Equine Veterinary Journal, 51(3), 415–421.

By: E. Martin  n, J. Schirmer n, S. Jones n  & J. Davis *

author keywords: horse; leucocyte; E prostanoid receptor agonist; pharmacokinetics; inflammation; tumour necrosis factor-
MeSH headings : Abortifacient Agents, Nonsteroidal / administration & dosage; Abortifacient Agents, Nonsteroidal / pharmacokinetics; Administration, Oral; Animals; Area Under Curve; Cells, Cultured; Horse Diseases / drug therapy; Horse Diseases / metabolism; Horses / blood; Horses / metabolism; Inflammation / drug therapy; Inflammation / metabolism; Inflammation / veterinary; Leukocytes / drug effects; Leukocytes / metabolism; Misoprostol / administration & dosage; Misoprostol / pharmacokinetics
TL;DR: Misoprostol is rapidly absorbed following oral administration in horses, and a single 5 μg/kg dose had no significant inhibitory effect on ex vivo LPS‐stimulated TNFα mRNA production in leucocytes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: May 6, 2019

2018 journal article

Pharmacokinetics, pharmacodynamics and clinical use of trazodone and its active metabolite m-chlorophenylpiperazine in the horse

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 41(3), 393–401.

By: J. Davis *, J. Schirmer n & E. Medlin n

author keywords: adverse drug reaction; equine; sedative; serotonin antagonist and reuptake inhibitor
MeSH headings : Administration, Oral; Animals; Anti-Anxiety Agents / administration & dosage; Anti-Anxiety Agents / pharmacokinetics; Anti-Anxiety Agents / pharmacology; Area Under Curve; Cross-Over Studies; Dose-Response Relationship, Drug; Half-Life; Horses / blood; Male; Piperazines / administration & dosage; Piperazines / pharmacokinetics; Piperazines / pharmacology; Serotonin Receptor Agonists / administration & dosage; Serotonin Receptor Agonists / pharmacokinetics; Serotonin Receptor Agonists / pharmacology; Trazodone / administration & dosage; Trazodone / pharmacokinetics; Trazodone / pharmacology
TL;DR: Trazodone was successful in modifying behavioural problems to some degree in 17 of 18 clinical cases and Tolerance and subsequent lack of drug effect occurred in two of 18clinical cases following 14 or 21 days of use. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Effects of quinapril on angiotensin converting enzyme and plasma renin activity as well as pharmacokinetic parameters of quinapril and its active metabolite, quinaprilat, after intravenous and oral administration to mature horses

EQUINE VETERINARY JOURNAL, 46(6), 729–733.

By: J. Davis n, K. Kruger n, D. LaFevers n, B. Barlow n, J. Schirmer n & B. Breuhaus n 

author keywords: horse; angiotensin converting enzyme; renin; mitral insufficiency
MeSH headings : Administration, Intravenous; Administration, Oral; Angiotensin-Converting Enzyme Inhibitors / blood; Angiotensin-Converting Enzyme Inhibitors / metabolism; Angiotensin-Converting Enzyme Inhibitors / pharmacokinetics; Angiotensin-Converting Enzyme Inhibitors / pharmacology; Animals; Area Under Curve; Gene Expression Regulation, Enzymologic; Half-Life; Horses / blood; Horses / metabolism; Peptidyl-Dipeptidase A / blood; Peptidyl-Dipeptidase A / genetics; Peptidyl-Dipeptidase A / metabolism; Quinapril; Renin / blood; Tetrahydroisoquinolines / blood; Tetrahydroisoquinolines / metabolism; Tetrahydroisoquinolines / pharmacokinetics; Tetrahydroisoquinolines / pharmacology
TL;DR: Results suggest that, despite low plasma concentrations, quinapril has sufficient oral absorption to produce inhibition of ACE in healthy horses and provides a potential treatment alternative for horses with cardiovascular and renal disease. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Pharmacokinetics and pharmacodynamics of three formulations of firocoxib in healthy horses

Journal of Veterinary Pharmacology and Therapeutics, 38(3), 249–256.

By: B. Holland n, C. Fogle n , A. Blikslager n , A. Curling n, B. Barlow n, J. Schirmer n, J. Davis n

Contributors: B. Holland n, C. Fogle n , A. Blikslager n , A. Curling n, B. Barlow n, J. Schirmer n, J. Davis n

MeSH headings : 4-Butyrolactone / administration & dosage; 4-Butyrolactone / analogs & derivatives; 4-Butyrolactone / blood; 4-Butyrolactone / pharmacokinetics; 4-Butyrolactone / pharmacology; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Anti-Inflammatory Agents, Non-Steroidal / pharmacology; Cross-Over Studies; Dinoprostone / blood; Horses / metabolism; Injections, Intravenous / veterinary; Ointments; Sulfones / administration & dosage; Sulfones / blood; Sulfones / pharmacokinetics; Sulfones / pharmacology; Tablets; Thromboxane B2 / blood
TL;DR: This study indicates a lack of bioequivalence between the oral formulations of firocoxib when administered as a single dose to healthy horses, as well as a higher Cmax, shorter Tmax, and greater AUC for the paste compared to the tablet. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

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