@article{irvin_zurney_ooms_chappell_dermody_sherry_2012, title={A Single-Amino-Acid Polymorphism in Reovirus Protein mu 2 Determines Repression of Interferon Signaling and Modulates Myocarditis}, volume={86}, ISSN={["0022-538X"]}, DOI={10.1128/jvi.06236-11}, abstractNote={ABSTRACT}, number={4}, journal={JOURNAL OF VIROLOGY}, author={Irvin, Susan C. and Zurney, Jennifer and Ooms, Laura S. and Chappell, James D. and Dermody, Terence S. and Sherry, Barbara}, year={2012}, month={Feb}, pages={2302–2311} } @article{zurney_kobayashi_holm_dermody_sherry_2009, title={Reovirus mu 2 Protein Inhibits Interferon Signaling through a Novel Mechanism Involving Nuclear Accumulation of Interferon Regulatory Factor 9}, volume={83}, ISSN={["1098-5514"]}, DOI={10.1128/JVI.01787-08}, abstractNote={ABSTRACT}, number={5}, journal={JOURNAL OF VIROLOGY}, author={Zurney, Jennifer and Kobayashi, Takeshi and Holm, Geoffrey H. and Dermody, Terence S. and Sherry, Barbara}, year={2009}, month={Mar}, pages={2178–2187} } @article{zurney_howard_sherry_2007, title={Basal expression levels of IFNAR and Jak-STAT components are determinants of cell-type-specific differences in cardiac antiviral responses}, volume={81}, ISSN={["0022-538X"]}, DOI={10.1128/JVI.01172-07}, abstractNote={ABSTRACT}, number={24}, journal={JOURNAL OF VIROLOGY}, author={Zurney, Jennifer and Howard, Kristina E. and Sherry, Barbara}, year={2007}, month={Dec}, pages={13668–13680} } @article{holm_zurney_tumilasci_leveille_danthi_hiscott_sherry_dermody_2007, title={Retinoic acid-inducible gene-I and interferon-beta promoter stimulator-1 augment proapoptotic responses following mammalian reovirus infection via interferon regulatory factor-3}, volume={282}, ISSN={["1083-351X"]}, DOI={10.1074/jbc.M702112200}, abstractNote={During viral infection, cells initiate antiviral responses to contain replication and inhibit virus spread. One protective mechanism involves activation of transcription factors interferon regulatory factor-3 (IRF-3) and NF-κB, resulting in secretion of the antiviral cytokine, interferon-β. Another is induction of apoptosis, killing the host cell before virus disseminates. Mammalian reovirus induces both interferon-β and apoptosis, raising the possibility that both pathways are initiated by a common cellular sensor. We show here that reovirus activates IRF-3 with kinetics that parallel the activation of NF-κB, a known mediator of reovirus-induced apoptosis. Activation of IRF-3 requires functional retinoic acid inducible gene-I and interferon-β promoter stimulator-1, but these intracellular sensors are dispensable for activation of NF-κB. Interferon-β promoter stimulator-1 and IRF-3 are required for efficient apoptosis following reovirus infection, suggesting a common mechanism of antiviral cytokine induction and activation of the cell death response.}, number={30}, journal={JOURNAL OF BIOLOGICAL CHEMISTRY}, author={Holm, Geoffrey H. and Zurney, Jennifer and Tumilasci, Vanessa and Leveille, Simon and Danthi, Pranav and Hiscott, John and Sherry, Barbara and Dermody, Terence S.}, year={2007}, month={Jul}, pages={21953–21961} }